DE3677816D1 - Synthese von 3s, 4s-boc-statin. - Google Patents

Synthese von 3s, 4s-boc-statin.

Info

Publication number
DE3677816D1
DE3677816D1 DE8686301869T DE3677816T DE3677816D1 DE 3677816 D1 DE3677816 D1 DE 3677816D1 DE 8686301869 T DE8686301869 T DE 8686301869T DE 3677816 T DE3677816 T DE 3677816T DE 3677816 D1 DE3677816 D1 DE 3677816D1
Authority
DE
Germany
Prior art keywords
boc
statin
synthesis
statine
isomer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE8686301869T
Other languages
English (en)
Inventor
Joseph Repine
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Warner Lambert Co LLC
Original Assignee
Warner Lambert Co LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co LLC filed Critical Warner Lambert Co LLC
Application granted granted Critical
Publication of DE3677816D1 publication Critical patent/DE3677816D1/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Light Receiving Elements (AREA)
DE8686301869T 1985-05-20 1986-03-14 Synthese von 3s, 4s-boc-statin. Expired - Fee Related DE3677816D1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/735,933 US4650897A (en) 1985-05-20 1985-05-20 Organic synthesis

Publications (1)

Publication Number Publication Date
DE3677816D1 true DE3677816D1 (de) 1991-04-11

Family

ID=24957822

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8686301869T Expired - Fee Related DE3677816D1 (de) 1985-05-20 1986-03-14 Synthese von 3s, 4s-boc-statin.

Country Status (6)

Country Link
US (1) US4650897A (de)
EP (1) EP0202736B1 (de)
JP (1) JPS61268662A (de)
AT (1) ATE61346T1 (de)
DE (1) DE3677816D1 (de)
ES (1) ES8707176A1 (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0772167B2 (ja) * 1986-09-04 1995-08-02 サントリー株式会社 ４―アミノ―３―ヒドロキシ酪酸誘導体の製法
US4681972A (en) * 1986-09-16 1987-07-21 Warner-Lambert Company Separation of diastereomers
GB9625455D0 (en) * 1996-12-07 1997-01-22 Glaxo Group Ltd Process for resolving mixtures of carbocyclic steroisomers

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5069039A (de) * 1973-10-23 1975-06-09
US4397786A (en) * 1981-11-23 1983-08-09 Merck & Co., Inc. Method of preparing statine and derivatives
US4487963A (en) * 1983-01-03 1984-12-11 Merck & Co., Inc. Enantioselective synthesis of 4-amino-3-hydroxy-2,4-(disubstituted)pentanoic acid
IT1164319B (it) * 1983-07-27 1987-04-08 Blaschim Spa Procedimento per la risoluzione dell'acido (+-)2-(6'-metossi-2'-naftil)-propionico

Also Published As

Publication number Publication date
JPS61268662A (ja) 1986-11-28
ES8707176A1 (es) 1987-07-16
ES555144A0 (es) 1987-07-16
EP0202736B1 (de) 1991-03-06
EP0202736A3 (en) 1987-07-29
EP0202736A2 (de) 1986-11-26
ATE61346T1 (de) 1991-03-15
US4650897A (en) 1987-03-17

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8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee