ES8707176A1 - Procedimiento para producir 3s8 4s-boc-estanina - Google Patents

Procedimiento para producir 3s8 4s-boc-estanina

Info

Publication number
ES8707176A1
ES8707176A1 ES555144A ES555144A ES8707176A1 ES 8707176 A1 ES8707176 A1 ES 8707176A1 ES 555144 A ES555144 A ES 555144A ES 555144 A ES555144 A ES 555144A ES 8707176 A1 ES8707176 A1 ES 8707176A1
Authority
ES
Spain
Prior art keywords
statine
boc
synthesis
isomer
salt
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES555144A
Other languages
English (en)
Other versions
ES555144A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Warner Lambert Co LLC
Original Assignee
Warner Lambert Co LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co LLC filed Critical Warner Lambert Co LLC
Publication of ES555144A0 publication Critical patent/ES555144A0/es
Publication of ES8707176A1 publication Critical patent/ES8707176A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Light Receiving Elements (AREA)

Abstract

PROCEDIMIENTO PARA PRODUCIR 3S,4S-BOCESTANINA. CONSISTE EN CRISTALIZAR FRACCIONALMENTE A LAS SALES DE R-(B)-A-FENETILAMINA O METILBENCILAMINA DE UNA MEZCLA DE ISOMEROS 3RS,4S DE LA ESTANINA CON LA A-FENETILAMINA, PARA PRODUCIR LA 3S,4S-BROCESTANINA. SE UTILIZAN COMO INHIBIDORES DE LAS PROTEASAS COMO SON LA PEPSINA Y RESINA EN FARMACIA.
ES555144A 1985-05-20 1986-05-20 Procedimiento para producir 3s8 4s-boc-estanina Expired ES8707176A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/735,933 US4650897A (en) 1985-05-20 1985-05-20 Organic synthesis

Publications (2)

Publication Number Publication Date
ES555144A0 ES555144A0 (es) 1987-07-16
ES8707176A1 true ES8707176A1 (es) 1987-07-16

Family

ID=24957822

Family Applications (1)

Application Number Title Priority Date Filing Date
ES555144A Expired ES8707176A1 (es) 1985-05-20 1986-05-20 Procedimiento para producir 3s8 4s-boc-estanina

Country Status (6)

Country Link
US (1) US4650897A (es)
EP (1) EP0202736B1 (es)
JP (1) JPS61268662A (es)
AT (1) ATE61346T1 (es)
DE (1) DE3677816D1 (es)
ES (1) ES8707176A1 (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0772167B2 (ja) * 1986-09-04 1995-08-02 サントリー株式会社 ４―アミノ―３―ヒドロキシ酪酸誘導体の製法
US4681972A (en) * 1986-09-16 1987-07-21 Warner-Lambert Company Separation of diastereomers
GB9625455D0 (en) * 1996-12-07 1997-01-22 Glaxo Group Ltd Process for resolving mixtures of carbocyclic steroisomers

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5069039A (es) * 1973-10-23 1975-06-09
US4397786A (en) * 1981-11-23 1983-08-09 Merck & Co., Inc. Method of preparing statine and derivatives
US4487963A (en) * 1983-01-03 1984-12-11 Merck & Co., Inc. Enantioselective synthesis of 4-amino-3-hydroxy-2,4-(disubstituted)pentanoic acid
IT1164319B (it) * 1983-07-27 1987-04-08 Blaschim Spa Procedimento per la risoluzione dell'acido (+-)2-(6'-metossi-2'-naftil)-propionico

Also Published As

Publication number Publication date
JPS61268662A (ja) 1986-11-28
DE3677816D1 (de) 1991-04-11
EP0202736B1 (en) 1991-03-06
US4650897A (en) 1987-03-17
EP0202736A3 (en) 1987-07-29
ES555144A0 (es) 1987-07-16
ATE61346T1 (de) 1991-03-15
EP0202736A2 (en) 1986-11-26

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Legal Events

Date Code Title Description
MM4A Patent lapsed

Effective date: 19960506