ATE318815T1 - Verfahren zur herstellung von enantiomeren von indol-2,3-dion-3-oximderivaten - Google Patents

Verfahren zur herstellung von enantiomeren von indol-2,3-dion-3-oximderivaten

Info

Publication number
ATE318815T1
ATE318815T1 AT03792147T AT03792147T ATE318815T1 AT E318815 T1 ATE318815 T1 AT E318815T1 AT 03792147 T AT03792147 T AT 03792147T AT 03792147 T AT03792147 T AT 03792147T AT E318815 T1 ATE318815 T1 AT E318815T1
Authority
AT
Austria
Prior art keywords
dione
indole
oxime derivatives
producing enantiomers
enantiomers
Prior art date
Application number
AT03792147T
Other languages
English (en)
Inventor
Alex Haahr Gouliaev
William Dalby Brown
Frank Waetjen
Original Assignee
Neurosearch As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neurosearch As filed Critical Neurosearch As
Application granted granted Critical
Publication of ATE318815T1 publication Critical patent/ATE318815T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02Oxygen as only ring hetero atoms
    • C12P17/04Oxygen as only ring hetero atoms containing a five-membered hetero ring, e.g. griseofulvin, vitamin C
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/003Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions
    • C12P41/004Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions by esterification of alcohol- or thiol groups in the enantiomers or the inverse reaction

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT03792147T 2002-08-22 2003-08-13 Verfahren zur herstellung von enantiomeren von indol-2,3-dion-3-oximderivaten ATE318815T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DKPA200201237 2002-08-22

Publications (1)

Publication Number Publication Date
ATE318815T1 true ATE318815T1 (de) 2006-03-15

Family

ID=31896777

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03792147T ATE318815T1 (de) 2002-08-22 2003-08-13 Verfahren zur herstellung von enantiomeren von indol-2,3-dion-3-oximderivaten

Country Status (12)

Country Link
US (1) US7632948B2 (de)
EP (1) EP1532146B1 (de)
JP (1) JP2006503011A (de)
CN (1) CN1296372C (de)
AT (1) ATE318815T1 (de)
AU (1) AU2003250323A1 (de)
CA (1) CA2493244A1 (de)
DE (1) DE60303825T2 (de)
DK (1) DK1532146T3 (de)
MX (1) MXPA05002056A (de)
NZ (1) NZ537810A (de)
WO (1) WO2004018466A2 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2369746A1 (en) 1999-05-19 2000-11-30 Neurosearch A/S Inhibitors of proton-gated cation channels and their use in the treatment of ischaemic disorders
PE20061413A1 (es) * 2005-04-29 2007-01-20 Wyeth Corp Proceso para preparar isatinas con control de formacion de subproductos
AU2006317545B2 (en) 2005-11-23 2012-04-12 Aros Pharma Aps Compositions and methods for modulating gated ion channels
CA2652307A1 (en) * 2006-04-10 2007-10-18 Painceptor Pharma Corporation Compositions and methods for modulating gated ion channels
WO2008144931A1 (en) * 2007-05-30 2008-12-04 Painceptor Pharma Corporation Compositions and methods for modulating gated ion channels
CN112451682A (zh) 2015-11-25 2021-03-09 乐高化学生物科学股份有限公司 包含自降解基团的缀合物及其相关方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2542941B2 (ja) * 1990-02-02 1996-10-09 チッソ株式会社 光学活性ヒドロキシラクトン類の製造方法
JP2939646B2 (ja) 1990-07-17 1999-08-25 チッソ株式会社 4―置換―2―ヒドロキシブタン酸エステルおよび製造法
JP3789951B2 (ja) * 1993-11-25 2006-06-28 三共アグロ株式会社 O−n結合を有する糖誘導体及び製造方法
UA54403C2 (uk) * 1996-10-01 2003-03-17 Н'Юросерч А/С Похідні індол-2,3-діон-3-оксиму, фармацевтична композиція, спосіб лікування розладу чи захворювання ссавців, у тому числі людини та спосіб одержання похідних індол-2,3-діон-3-оксиму
WO1999049864A1 (en) * 1998-03-31 1999-10-07 Neurosearch A/S Indole-2,3-dione-3-oxime derivatives for therapeutic use
AU7418100A (en) 1999-09-08 2001-04-10 Lonza A.G. Method for producing (r) or (s)-hydroxy-gamma-butyrolactone

Also Published As

Publication number Publication date
US7632948B2 (en) 2009-12-15
JP2006503011A (ja) 2006-01-26
WO2004018466A3 (en) 2004-03-25
EP1532146A2 (de) 2005-05-25
CN1296372C (zh) 2007-01-24
WO2004018466A2 (en) 2004-03-04
DE60303825D1 (de) 2006-04-27
DK1532146T3 (da) 2006-07-03
AU2003250323A1 (en) 2004-03-11
EP1532146B1 (de) 2006-03-01
MXPA05002056A (es) 2005-06-08
DE60303825T2 (de) 2006-08-17
CN1671704A (zh) 2005-09-21
CA2493244A1 (en) 2004-03-04
US20060178391A1 (en) 2006-08-10
NZ537810A (en) 2006-10-27

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