DK1532146T3 - Fremgangsmåde til fremstilling af enantiomerer af indol-2,3-dion-3-oximderivater - Google Patents

Fremgangsmåde til fremstilling af enantiomerer af indol-2,3-dion-3-oximderivater

Info

Publication number
DK1532146T3
DK1532146T3 DK03792147T DK03792147T DK1532146T3 DK 1532146 T3 DK1532146 T3 DK 1532146T3 DK 03792147 T DK03792147 T DK 03792147T DK 03792147 T DK03792147 T DK 03792147T DK 1532146 T3 DK1532146 T3 DK 1532146T3
Authority
DK
Denmark
Prior art keywords
dione
indole
enantiomers
preparation
oxime derivatives
Prior art date
Application number
DK03792147T
Other languages
English (en)
Inventor
Alex Gouliaev
William Brown
Frank Waetjen
Original Assignee
Neurosearch As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neurosearch As filed Critical Neurosearch As
Application granted granted Critical
Publication of DK1532146T3 publication Critical patent/DK1532146T3/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02Oxygen as only ring hetero atoms
    • C12P17/04Oxygen as only ring hetero atoms containing a five-membered hetero ring, e.g. griseofulvin, vitamin C
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/003Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions
    • C12P41/004Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions by esterification of alcohol- or thiol groups in the enantiomers or the inverse reaction

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DK03792147T 2002-08-22 2003-08-13 Fremgangsmåde til fremstilling af enantiomerer af indol-2,3-dion-3-oximderivater DK1532146T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DKPA200201237 2002-08-22

Publications (1)

Publication Number Publication Date
DK1532146T3 true DK1532146T3 (da) 2006-07-03

Family

ID=31896777

Family Applications (1)

Application Number Title Priority Date Filing Date
DK03792147T DK1532146T3 (da) 2002-08-22 2003-08-13 Fremgangsmåde til fremstilling af enantiomerer af indol-2,3-dion-3-oximderivater

Country Status (12)

Country Link
US (1) US7632948B2 (da)
EP (1) EP1532146B1 (da)
JP (1) JP2006503011A (da)
CN (1) CN1296372C (da)
AT (1) ATE318815T1 (da)
AU (1) AU2003250323A1 (da)
CA (1) CA2493244A1 (da)
DE (1) DE60303825T2 (da)
DK (1) DK1532146T3 (da)
MX (1) MXPA05002056A (da)
NZ (1) NZ537810A (da)
WO (1) WO2004018466A2 (da)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU4910500A (en) 1999-05-19 2000-12-12 Neurosearch A/S Inhibitors of proton-gated cation channels and their use in the treatment of ischaemic disorders
PE20061413A1 (es) * 2005-04-29 2007-01-20 Wyeth Corp Proceso para preparar isatinas con control de formacion de subproductos
WO2007059608A1 (en) 2005-11-23 2007-05-31 Painceptor Pharma Corporation Compositions and methods for modulating gated ion channels
EP2010529A1 (en) * 2006-04-10 2009-01-07 PainCeptor Pharma Corp. Compositions and methods for modulating gated ion channels
WO2008144931A1 (en) * 2007-05-30 2008-12-04 Painceptor Pharma Corporation Compositions and methods for modulating gated ion channels
DK3380124T3 (da) 2015-11-25 2024-06-24 Ligachem Biosciences Inc Konjugater omfattende selv-immolative grupper og fremgangsmåder relateret dertil

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2542941B2 (ja) * 1990-02-02 1996-10-09 チッソ株式会社 光学活性ヒドロキシラクトン類の製造方法
JP2939646B2 (ja) * 1990-07-17 1999-08-25 チッソ株式会社 4―置換―2―ヒドロキシブタン酸エステルおよび製造法
JP3789951B2 (ja) * 1993-11-25 2006-06-28 三共アグロ株式会社 O−n結合を有する糖誘導体及び製造方法
UA54403C2 (uk) 1996-10-01 2003-03-17 Н'Юросерч А/С Похідні індол-2,3-діон-3-оксиму, фармацевтична композиція, спосіб лікування розладу чи захворювання ссавців, у тому числі людини та спосіб одержання похідних індол-2,3-діон-3-оксиму
AU751414B2 (en) * 1998-03-31 2002-08-15 Neurosearch A/S Indole-2,3-dione-3-oxime derivatives for therapeutic use
WO2001018231A2 (de) * 1999-09-08 2001-03-15 Lonza Ag VERFAHREN ZUR HERSTELLUNG VON (R)- ODER (S)-HYDROXY-η-BUTYROLACTON

Also Published As

Publication number Publication date
MXPA05002056A (es) 2005-06-08
DE60303825T2 (de) 2006-08-17
CA2493244A1 (en) 2004-03-04
AU2003250323A1 (en) 2004-03-11
WO2004018466A3 (en) 2004-03-25
DE60303825D1 (de) 2006-04-27
EP1532146A2 (en) 2005-05-25
CN1296372C (zh) 2007-01-24
NZ537810A (en) 2006-10-27
WO2004018466A2 (en) 2004-03-04
JP2006503011A (ja) 2006-01-26
CN1671704A (zh) 2005-09-21
US20060178391A1 (en) 2006-08-10
ATE318815T1 (de) 2006-03-15
EP1532146B1 (en) 2006-03-01
US7632948B2 (en) 2009-12-15

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