LV10907B - Peg/protein derivatives of interferon - Google Patents
Peg/protein derivatives of interferon Download PDFInfo
- Publication number
- LV10907B LV10907B LVP-93-1040A LV931040A LV10907B LV 10907 B LV10907 B LV 10907B LV 931040 A LV931040 A LV 931040A LV 10907 B LV10907 B LV 10907B
- Authority
- LV
- Latvia
- Prior art keywords
- interferon
- conjugate
- compound
- peg
- lower alkyl
- Prior art date
Links
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/555—Interferons [IFN]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
- C07D213/64—One oxygen atom attached in position 2 or 6
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- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
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- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/96—Esters of carbonic or haloformic acids
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/555—Interferons [IFN]
- C07K14/56—IFN-alpha
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K38/00—Medicinal preparations containing peptides
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
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- Engineering & Computer Science (AREA)
- Public Health (AREA)
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- Biophysics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Claims (25)
- LV 10907 Izgudrojuma formula 1. Interferona un polietilēnglikola konjugēts ar formulu (I) 0 RO-(CH2CHO)x-(CH2CHOL-(CH2CHO)z-CH2CH-Wli Ιο 7 1,3 I4 R1 RZ R R1 II ' ^ NH-- interferon m kurā: R ir zemākā alkilgrupa; R1, R2, R3 un R1 ir ūdeņraža atoms vai zemākā alkilgrupa; m ir vesels skaitlis, kas ir robežās no 1 līdz interferona molekulā pieejamo aminogrupu skaitam; W ir 0 vai NH; x ir skaitlis robežās no 1 fidz 1000; y un z katrs ir skaitlis robežās no 0 līdz 1000, pie tam x, y un z summa ir skaitlis robežās no 3 Hdz 1000; ar noteikumu, ka vismaz viens no R1, R2, R3 un R1 ir zemākā alkilgrupa. 1 1 līdz 30000 daltoniem.
- 2 Interferona konjugēts pēc 1. punkta, kas atšķiras ar to, ka x, y un z ir 3 ņemti tādi, lai konjugāta polimērās daļas molekulmasa būtu robežās no 300
- 3. Interferona konjugēts pēc 1. punkta, kas atšķiras ar to, ka m ir 1.
- 4. Interferona konjugēts pēc 1. punkta, kas atšķiras ar to, ka R ir metilgrupa.
- 5. Interferona konjugēts pēc 2. punkta, kas atšķiras ar to, ka x, y un z ir ņemti tādi, lai konjugēta polimērās daļas molekulmasa būtu robežās no 1000 līdz 5000 daltoniem.
- 6. Interferona konjugēts pēc 2. punkta, kas atšķiras ar to, ka x, y un z ir ņemti tādi, lai konjugāta polimērās daļas molekulmasa būtu robežās no 1000 līdz 2200 daltoniem.
- 7. Interferona konjugēts pēc 1. punkta, kas atšķiras ar to, ka x un y ir 5 - 500 un z ir 0 - 4.
- 8. Interferona konjugēts pēc 1. punkta, kas atšķiras ar to, ka x ir 10-100, yir 1 -10 un z ir 0-4.
- 9. Interferona konjugēts pēc 1. punkta, kas atšķiras ar to, ka interferons ir interferons a2A.
- 10. Interferona konjugēts pēc 9. punkta, kas atšķiras ar to, ka W ir NH; m ir 1; R, R2 un R4 ir CH3; R1 ir Η; x ir 18,6; y ir 1,6; z ir 0.
- 11. Savienojums ar formulu (II)kurā: R ir zemākā alkilgrupa; R1, R2, R3 un R4 ir ūdeņraža atoms vai zemākā alkilgrupa; W ir O vai NH; x ir skaitlis robežās no 1 fTdz 1000; y un z katrs ir skaitlis robežās no 0 līdz 1000, pie tam x, y un z summa ir skaitlis robežās no 3 līdz 1000; ar noteikumu, ka, ja W ir NH, vai arī W ir O un R5 ir H, tad vismaz viens no R1, R2, R3 un R4 ir zemākā alkilgrupa. 2 LV 10907
- 12. Savienojums pēc 11. punkta, kas atšķiras ar to, ka x, y un z ir ņemti tādi, lai savienojuma molekulmasa būtu robežās no 300 līdz 30000 daltoniem.
- 13. Savienojums pēc 11. punkta, kas atšķiras ar to, ka R ir metilgrupa.
- 14. Savienojums pēc 13. punkta, kas atšķiras ar to, ka x ir 10 - 100, y ir 1 -10 un z ir 0 - 4.
- 15. Savienojums ar formulu (III) RO-iCHgCHOl^CHjCHO^CHjCHO^-CH^HO R1 R2 R3 R4 —C=0 III kurā: R ir zemākā alkilgrupa; R1, R2, R3 un R4 ir ūdeņraža atoms vai metilgrupa; x ir skaitlis robežās no 1 līdz 1000; y un z katrs ir skaitlis robežās no 0 līdz 1000, pie tam x, y un z summa ir skaitlis robežās no 3 līdz 1000.
- 16. Savienojums pēc 15. punkta, kas atšķiras ar to, ka x, y un z ir ņemti tādi, lai savienojuma molekulmasa būtu robežās no 300 līdz 30000 daltoniem.
- 17. Savienojums pēc 15. punkta, kas atšķiras ar to, ka vismaz viens no R1, R2, R3 un R4 ir zemākā alkilgrupa.
- 18. Savienojums pēc 15. punkta, kas atšķiras ar to, ka R ir metilgrupa.
- 19. Interferona konjugētu pēc jebkura no 1.-10. punktiem pielietojums par ārstniecības vielām slimību profilaksei un ārstēšanai.
- 20. Paņēmiens interferona konjugātu pēc jebkura no 1.-10. punktiem iegūšanai, kas atšķiras ar to, ka interferonu vai tā sāli apstrādā ar savienojumu pēc jebkura no 11.-18. punktiem un izolē interferona konjugātu no reakcijas maisījuma.
- 21. Farmaceitiskās kompozīcijas, kas atšķiras ar to, ka tās satur interferona konjugātu pēc jebkura no 1.-10. punktiem un terapeitiski inertu nesēju. 3
- 22. Farmaceitiskās kompozīcijas imūnomodulācijas traucējumu, piemēram, jaunveidojumu vai infekcijas slimību, ārstēšanai un profilaksei, kas atšķiras ar to, ka satur interferona konjugētu pēc jebkura no 1.-10. punktiem un terapeitiski inertu nesēju.
- 23. Interferona konjugētu pēc jebkura no 1.-10. punktiem pielietojums dzīvo būtņu, izņemot cilvēku, slimību profilaksei un ārstēšanai.
- 24. Interferona konjugētu pēc jebkura no 1.-10. punktiem pielietojums tādu medikamentu ražošanai, kas paredzēti slimību profilaksei un ārstēšanai.
- 25. Interferona konjugēts pēc jebkura no 1.-10. punktiem, kas pagatavots ar paņēmienu pēc 20. punkta vai tā acīmredzamu ķīmisko ekvivalentu. 4
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US07/935,770 US5382657A (en) | 1992-08-26 | 1992-08-26 | Peg-interferon conjugates |
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- 1993-08-20 AU AU44780/93A patent/AU668742B2/en not_active Ceased
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