LT3523302T - Pakeistieji pirazolo[1,5-a]piridino junginiai kaip ret kinazės slopintojai - Google Patents

Pakeistieji pirazolo[1,5-a]piridino junginiai kaip ret kinazės slopintojai

Info

Publication number
LT3523302T
LT3523302T LTEPPCT/US2017/055993T LT17055993T LT3523302T LT 3523302 T LT3523302 T LT 3523302T LT 17055993 T LT17055993 T LT 17055993T LT 3523302 T LT3523302 T LT 3523302T
Authority
LT
Lithuania
Prior art keywords
kinase inhibitors
pyridine compounds
ret kinase
substituted pyrazolo
pyrazolo
Prior art date
Application number
LTEPPCT/US2017/055993T
Other languages
English (en)
Lithuanian (lt)
Inventor
Steven W. Andrews
Sean ARONOW
James F. Blake
Barbara J. Brandhuber
James Collier
Adam Cook
Julia Haas
Yutong Jiang
Gabrielle R. KOLAKOWSKI
Elizabeth A. MCFADDIN
Megan L. MCKENNEY
Oren T. MCKNULTY
Andrew T. Metcalf
David A. Moreno
Ginelle A. RAMANN
Tony P. Tang
Li Ren
Shane M. WALLS
Original Assignee
Array Biopharma, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Array Biopharma, Inc. filed Critical Array Biopharma, Inc.
Publication of LT3523302T publication Critical patent/LT3523302T/lt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4162—1,2-Diazoles condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
LTEPPCT/US2017/055993T 2016-10-10 2017-10-10 Pakeistieji pirazolo[1,5-a]piridino junginiai kaip ret kinazės slopintojai LT3523302T (lt)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US201662406275P 2016-10-10 2016-10-10
US201762447849P 2017-01-18 2017-01-18
US201762491180P 2017-04-27 2017-04-27
US201762531690P 2017-07-12 2017-07-12
US201762566030P 2017-09-29 2017-09-29
PCT/US2017/055993 WO2018071454A1 (en) 2016-10-10 2017-10-10 Substituted pyrazolo[1,5-a]pyridine compounds as ret kinase inhibitors

Publications (1)

Publication Number Publication Date
LT3523302T true LT3523302T (lt) 2022-09-12

Family

ID=60153576

Family Applications (1)

Application Number Title Priority Date Filing Date
LTEPPCT/US2017/055993T LT3523302T (lt) 2016-10-10 2017-10-10 Pakeistieji pirazolo[1,5-a]piridino junginiai kaip ret kinazės slopintojai

Country Status (35)

Country Link
US (5) US10144734B2 (cg-RX-API-DMAC7.html)
EP (2) EP3523302B1 (cg-RX-API-DMAC7.html)
JP (1) JP7075399B2 (cg-RX-API-DMAC7.html)
KR (1) KR102287752B1 (cg-RX-API-DMAC7.html)
CN (1) CN110177786B (cg-RX-API-DMAC7.html)
AU (1) AU2017342027B2 (cg-RX-API-DMAC7.html)
BR (1) BR112019007143A2 (cg-RX-API-DMAC7.html)
CA (1) CA3039912A1 (cg-RX-API-DMAC7.html)
CL (1) CL2019000942A1 (cg-RX-API-DMAC7.html)
CO (1) CO2019004649A2 (cg-RX-API-DMAC7.html)
CR (1) CR20190224A (cg-RX-API-DMAC7.html)
CY (1) CY1125606T1 (cg-RX-API-DMAC7.html)
DK (1) DK3523302T3 (cg-RX-API-DMAC7.html)
DO (1) DOP2019000091A (cg-RX-API-DMAC7.html)
EC (1) ECSP19033052A (cg-RX-API-DMAC7.html)
ES (1) ES2926136T3 (cg-RX-API-DMAC7.html)
HR (1) HRP20221154T1 (cg-RX-API-DMAC7.html)
HU (1) HUE060089T2 (cg-RX-API-DMAC7.html)
IL (1) IL265918B (cg-RX-API-DMAC7.html)
JO (1) JOP20190077A1 (cg-RX-API-DMAC7.html)
LT (1) LT3523302T (cg-RX-API-DMAC7.html)
MD (1) MD3523302T2 (cg-RX-API-DMAC7.html)
MX (1) MX388140B (cg-RX-API-DMAC7.html)
PE (1) PE20191613A1 (cg-RX-API-DMAC7.html)
PH (1) PH12019500776A1 (cg-RX-API-DMAC7.html)
PL (1) PL3523302T3 (cg-RX-API-DMAC7.html)
PT (1) PT3523302T (cg-RX-API-DMAC7.html)
RS (1) RS63510B1 (cg-RX-API-DMAC7.html)
SA (1) SA519401544B1 (cg-RX-API-DMAC7.html)
SG (1) SG11201903187WA (cg-RX-API-DMAC7.html)
SI (1) SI3523302T1 (cg-RX-API-DMAC7.html)
TN (1) TN2019000107A1 (cg-RX-API-DMAC7.html)
TW (1) TWI752098B (cg-RX-API-DMAC7.html)
UA (1) UA125032C2 (cg-RX-API-DMAC7.html)
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