LT3277B - Prolonged release pharmaceutical preparation, polymeric composition as base for it and process for preparing thereof - Google Patents

Prolonged release pharmaceutical preparation, polymeric composition as base for it and process for preparing thereof Download PDF

Info

Publication number
LT3277B
LT3277B LTIP442A LTIP442A LT3277B LT 3277 B LT3277 B LT 3277B LT IP442 A LTIP442 A LT IP442A LT IP442 A LTIP442 A LT IP442A LT 3277 B LT3277 B LT 3277B
Authority
LT
Lithuania
Prior art keywords
acid
copolymer
release
microcapsules
glycolic acid
Prior art date
Application number
LTIP442A
Other languages
English (en)
Lithuanian (lt)
Inventor
Minoru Yamada
Seiko Ishiguro
Yasuaki Ogawa
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Publication of LTIP442A publication Critical patent/LTIP442A/xx
Publication of LT3277B publication Critical patent/LT3277B/lt

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/74Synthetic polymeric materials
    • A61K31/745Polymers of hydrocarbons
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005Wall or coating material
    • A61K9/5021Organic macromolecular compounds
    • A61K9/5031Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605Excipients; Inactive ingredients
    • A61K9/1629Organic macromolecular compounds
    • A61K9/1641Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647Polyesters, e.g. poly(lactide-co-glycolide)
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08LCOMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L67/00Compositions of polyesters obtained by reactions forming a carboxylic ester link in the main chain; Compositions of derivatives of such polymers
    • C08L67/04Polyesters derived from hydroxycarboxylic acids, e.g. lactones

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
LTIP442A 1990-10-16 1993-03-19 Prolonged release pharmaceutical preparation, polymeric composition as base for it and process for preparing thereof LT3277B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP27803790 1990-10-16
JP21704591 1991-08-28

Publications (2)

Publication Number Publication Date
LTIP442A LTIP442A (en) 1994-11-25
LT3277B true LT3277B (en) 1995-05-25

Family

ID=26521778

Family Applications (1)

Application Number Title Priority Date Filing Date
LTIP442A LT3277B (en) 1990-10-16 1993-03-19 Prolonged release pharmaceutical preparation, polymeric composition as base for it and process for preparing thereof

Country Status (24)

Country Link
US (1) US5304377A (de)
EP (1) EP0481732B1 (de)
JP (1) JP3196035B2 (de)
KR (1) KR100199119B1 (de)
CN (2) CN1043189C (de)
AT (1) ATE119035T1 (de)
AU (1) AU644019B2 (de)
CA (1) CA2053468C (de)
DE (1) DE69107773T2 (de)
DK (1) DK0481732T3 (de)
EE (1) EE02958B1 (de)
ES (1) ES2069221T3 (de)
FI (1) FI101454B (de)
GE (1) GEP19981287B (de)
IE (1) IE66705B1 (de)
LT (1) LT3277B (de)
LV (1) LV10055B (de)
MX (1) MX9101595A (de)
NO (1) NO302481B1 (de)
NZ (1) NZ240214A (de)
PT (1) PT99236B (de)
RU (1) RU2103005C1 (de)
UA (1) UA27707C2 (de)
ZA (1) ZA918168B (de)

Families Citing this family (92)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6323307B1 (en) 1988-08-08 2001-11-27 Cargill Dow Polymers, Llc Degradation control of environmentally degradable disposable materials
US5247059A (en) * 1992-01-24 1993-09-21 Cargill, Incorporated Continuous process for the manufacture of a purified lactide from esters of lactic acid
US6005067A (en) * 1992-01-24 1999-12-21 Cargill Incorporated Continuous process for manufacture of lactide polymers with controlled optical purity
US6326458B1 (en) 1992-01-24 2001-12-04 Cargill, Inc. Continuous process for the manufacture of lactide and lactide polymers
US5258488A (en) * 1992-01-24 1993-11-02 Cargill, Incorporated Continuous process for manufacture of lactide polymers with controlled optical purity
US5247058A (en) * 1992-01-24 1993-09-21 Cargill, Incorporated Continuous process for manufacture of lactide polymers with controlled optical purity
US5142023A (en) * 1992-01-24 1992-08-25 Cargill, Incorporated Continuous process for manufacture of lactide polymers with controlled optical purity
DK0615555T3 (da) * 1992-10-02 2001-07-09 Cargill Inc Tekstilmateriale af smeltestabil lactidpolymer og fremgangsmåde til fremstilling deraf
ES2123668T3 (es) * 1992-10-02 1999-01-16 Cargill Inc Papel que tiene un recubrimiento de polimero de lactida estable en estado fundido y procedimiento para su fabricacion.
US5338822A (en) * 1992-10-02 1994-08-16 Cargill, Incorporated Melt-stable lactide polymer composition and process for manufacture thereof
US6005068A (en) * 1992-10-02 1999-12-21 Cargill Incorporated Melt-stable amorphous lactide polymer film and process for manufacture thereof
TW333456B (en) * 1992-12-07 1998-06-11 Takeda Pharm Ind Co Ltd A pharmaceutical composition of sustained-release preparation the invention relates to a pharmaceutical composition of sustained-release preparation which comprises a physiologically active peptide.
UA61046C2 (en) 1992-12-07 2003-11-17 Takeda Chemical Industries Ltd Sustained-release preparation and method for its manufacture
US5716981A (en) * 1993-07-19 1998-02-10 Angiogenesis Technologies, Inc. Anti-angiogenic compositions and methods of use
DE69435342D1 (de) 1993-07-19 2011-05-05 Angiotech Pharm Inc Anti-Angiogene Mittel und Verfahren zu deren Verwendung
US5424289A (en) * 1993-07-30 1995-06-13 Alza Corporation Solid formulations of therapeutic proteins for gastrointestinal delivery
US5594091A (en) * 1994-02-21 1997-01-14 Takeda Chemical Industries, Ltd. Matrix for sustained-release preparation
FR2718642B1 (fr) * 1994-04-15 1996-07-12 Pf Medicament Microsphères biodégradables à libération contrôlée et leur procédé de préparation.
US5626862A (en) 1994-08-02 1997-05-06 Massachusetts Institute Of Technology Controlled local delivery of chemotherapeutic agents for treating solid tumors
JP2987064B2 (ja) * 1994-09-12 1999-12-06 グンゼ株式会社 人工硬膜
US6117455A (en) * 1994-09-30 2000-09-12 Takeda Chemical Industries, Ltd. Sustained-release microcapsule of amorphous water-soluble pharmaceutical active agent
DE69615763T2 (de) * 1995-07-13 2002-08-08 Mitsubishi Gas Chemical Co., Inc. Polymermischungen aliphatischer Polyester auf Basis von Polylactiden, Verfahren zu deren Herstellung und Verfahren zum Formen diese Mischungen
EP0765660A3 (de) * 1995-09-28 1998-09-23 Takeda Chemical Industries, Ltd. Mikrokapseln enthaltend 2-Piperazinon-1-essigsäure Verbindungen
US5637085A (en) * 1995-11-20 1997-06-10 Cardinale; Robert M. Method of cancer tumor treatment by slow release delivery of 1,2,4-benzotriazine oxides to tumor site
DE19545257A1 (de) 1995-11-24 1997-06-19 Schering Ag Verfahren zur Herstellung von morphologisch einheitlichen Mikrokapseln sowie nach diesem Verfahren hergestellte Mikrokapseln
CA2192782C (en) 1995-12-15 2008-10-14 Nobuyuki Takechi Production of microspheres
FR2744367B1 (fr) * 1996-02-02 1999-07-09 Emperaire Jean Claude Medicaments pour le declenchement de l'ovulation
DE69717263T2 (de) * 1996-03-28 2003-07-24 Takeda Chemical Industries, Ltd. Zubereitung mit verzögerter freisetzung und deren herstellung
DK0914102T3 (da) 1996-05-24 2006-01-09 Angiotech Pharm Inc Præparater og fremgangsmåder til behandling eller forebyggelse af syddomme i legemskanaler
JP4317599B2 (ja) * 1996-06-26 2009-08-19 武田薬品工業株式会社 徐放性製剤
US8603511B2 (en) 1996-08-27 2013-12-10 Baxter International, Inc. Fragmented polymeric compositions and methods for their use
US8303981B2 (en) 1996-08-27 2012-11-06 Baxter International Inc. Fragmented polymeric compositions and methods for their use
US6066325A (en) * 1996-08-27 2000-05-23 Fusion Medical Technologies, Inc. Fragmented polymeric compositions and methods for their use
US7435425B2 (en) * 2001-07-17 2008-10-14 Baxter International, Inc. Dry hemostatic compositions and methods for their preparation
US7871637B2 (en) 1996-08-27 2011-01-18 Baxter International Inc. Dry hemostatic compositions and methods for their preparation
US7235524B2 (en) * 1997-01-31 2007-06-26 Applied Research System Ars Holding N.V. Medicaments for initiating ovulation
US5945126A (en) * 1997-02-13 1999-08-31 Oakwood Laboratories L.L.C. Continuous microsphere process
IL132120A0 (en) 1997-04-03 2001-03-19 Guilford Pharm Inc Biodegradable terephthalate polyester-poly (phosphate) polymers compositions articles and methods for making and using the same
US6051558A (en) * 1997-05-28 2000-04-18 Southern Biosystems, Inc. Compositions suitable for controlled release of the hormone GnRH and its analogs
US6162241A (en) * 1997-08-06 2000-12-19 Focal, Inc. Hemostatic tissue sealants
KR19990065921A (ko) * 1998-01-19 1999-08-16 김충섭 항생제의서방성제제
US6099859A (en) * 1998-03-20 2000-08-08 Andrx Pharmaceuticals, Inc. Controlled release oral tablet having a unitary core
US6153212A (en) * 1998-10-02 2000-11-28 Guilford Pharmaceuticals Inc. Biodegradable terephthalate polyester-poly (phosphonate) compositions, articles, and methods of using the same
US6419709B1 (en) 1998-10-02 2002-07-16 Guilford Pharmaceuticals, Inc. Biodegradable terephthalate polyester-poly(Phosphite) compositions, articles, and methods of using the same
US6270802B1 (en) 1998-10-28 2001-08-07 Oakwood Laboratories L.L.C. Method and apparatus for formulating microspheres and microcapsules
GB2344287A (en) * 1998-12-03 2000-06-07 Ferring Bv Controlled release pharmaceutical formulation
BR9916117A (pt) * 1998-12-15 2001-09-04 Wolff Walsrode Ag Corpos moldados termoplásticos, biodegradáveis, exibindo uma estabilidade melhorada com respeito à hidrólise e uma resistência melhorada à rachadura por tensão
US6350464B1 (en) 1999-01-11 2002-02-26 Guilford Pharmaceuticals, Inc. Methods for treating ovarian cancer, poly (phosphoester) compositions, and biodegradable articles for same
US6537585B1 (en) 1999-03-26 2003-03-25 Guilford Pharmaceuticals, Inc. Methods and compositions for treating solid tumors
AU2002232824A1 (en) 2000-12-21 2002-07-01 Inhale Therapeutic Systems, Inc. Induced phase transition method for the production of microparticles containing hydrophobic active agents
CN1098883C (zh) * 2000-12-28 2003-01-15 武汉大学 分散度均匀的聚乳酸微球制备新方法
CA2451187C (en) 2001-06-22 2012-08-14 Southern Biosystems, Inc. Zero-order prolonged release coaxial implants
WO2003007782A2 (en) 2001-06-29 2003-01-30 Medgraft Microtech, Inc. Biodegradable injectable implants and related methods of manufacture and use
JP2003192773A (ja) * 2001-12-26 2003-07-09 Mitsui Chemicals Inc 生体吸収性ポリヒドロキシカルボン酸及びその製造法
AU2002367105A1 (en) * 2001-12-26 2003-07-15 Takeda Chemical Industries, Ltd. Novel microsphere and method for production thereof
US20040197301A1 (en) * 2003-02-18 2004-10-07 Zhong Zhao Hybrid polymers and methods of making the same
US8834864B2 (en) * 2003-06-05 2014-09-16 Baxter International Inc. Methods for repairing and regenerating human dura mater
US7927626B2 (en) * 2003-08-07 2011-04-19 Ethicon, Inc. Process of making flowable hemostatic compositions and devices containing such compositions
US7645459B2 (en) 2004-05-24 2010-01-12 The Procter & Gamble Company Dosage forms of bisphosphonates
US7645460B2 (en) * 2004-05-24 2010-01-12 The Procter & Gamble Company Dosage forms of risedronate
US20080287400A1 (en) * 2004-05-24 2008-11-20 Richard John Dansereau Low Dosage Forms Of Risedronate Or Its Salts
US20080286359A1 (en) * 2004-05-24 2008-11-20 Richard John Dansereau Low Dosage Forms Of Risedronate Or Its Salts
US20090275730A1 (en) * 2004-10-20 2009-11-05 Hiroyuki Oku Temperature responsive depsipeptide polymer
CN1923281B (zh) * 2005-08-30 2010-05-05 孔庆忠 一种含植物生物碱的抗癌缓释注射剂
EP1986603A2 (de) * 2006-01-13 2008-11-05 SurModics, Inc. Mikropartikel mit matrizen für die arzneimittelabgabe
BRPI0712088B8 (pt) * 2006-05-31 2021-06-22 Baxter Healthcare Sa uso de uma biomatriz de lâmina de colágeno de múltiplas camadas microscópicas não porosa e hermética a fluido
TWI436793B (zh) * 2006-08-02 2014-05-11 Baxter Int 快速作用之乾密封膠及其使用和製造方法
KR100845009B1 (ko) * 2007-08-07 2008-07-08 한국생명공학연구원 전하를 띠는 물질이 고착된 다공성 고분자 입자 및 그제조방법
CA2703103C (en) 2007-10-30 2017-05-09 Baxter Healthcare S.A. Use of a regenerative biofunctional collagen biomatrix for treating visceral or parietal defects
EP2259803B2 (de) 2008-02-29 2019-03-13 Ferrosan Medical Devices A/S Vorrichtung zur förderung von hämostase und/oder wundheilung
US9039783B2 (en) * 2009-05-18 2015-05-26 Baxter International, Inc. Method for the improvement of mesh implant biocompatibility
CN102802683B (zh) * 2009-06-16 2015-11-25 巴克斯特国际公司 止血海绵
WO2011024944A1 (ja) * 2009-08-31 2011-03-03 国立大学法人豊橋技術科学大学 ステレオコンプレックスポリエステル及びその製造方法
US8771258B2 (en) 2009-12-16 2014-07-08 Baxter International Inc. Hemostatic sponge
SA111320355B1 (ar) 2010-04-07 2015-01-08 Baxter Heathcare S A إسفنجة لايقاف النزف
JP6289096B2 (ja) 2010-06-01 2018-03-07 バクスター・インターナショナル・インコーポレイテッドBaxter International Incorp0Rated 乾燥した安定な止血組成物を作製するためのプロセス
MX345479B (es) 2010-06-01 2017-02-01 Baxter Int Inc * Proceso para elaborar composiciones hemostaticas secas y estables.
BR112012030455B1 (pt) 2010-06-01 2021-08-17 Baxter Healthcare S.A. Processo para fabricar uma composição hemostática seca e estável, recipiente acabado final, e, kit para administrar uma composição hemostática
WO2012014011A1 (en) 2010-07-26 2012-02-02 Universite De Geneve Compositions comprising polymers prepared from 2-hydroxyalkyl acids
KR102135484B1 (ko) 2011-10-11 2020-07-20 백스터 인터내셔널 인코포레이티드 지혈 조성물
WO2013053759A2 (en) 2011-10-11 2013-04-18 Baxter International Inc. Hemostatic compositions
SA112330957B1 (ar) 2011-10-27 2015-08-09 باكستر انترناشونال انك. تركيبات لإيقاف النزف
CA2865349C (en) 2012-03-06 2021-07-06 Ferrosan Medical Devices A/S Pressurized container containing haemostatic paste
CA2874290C (en) 2012-06-12 2020-02-25 Ferrosan Medical Devices A/S Dry haemostatic composition
US9724078B2 (en) 2013-06-21 2017-08-08 Ferrosan Medical Devices A/S Vacuum expanded dry composition and syringe for retaining same
CA2928963C (en) 2013-12-11 2020-10-27 Ferrosan Medical Devices A/S Dry composition comprising an extrusion enhancer
CN106999621B (zh) 2014-10-13 2020-07-03 弗罗桑医疗设备公司 用于止血和伤口愈合的干组合物
US10653837B2 (en) 2014-12-24 2020-05-19 Ferrosan Medical Devices A/S Syringe for retaining and mixing first and second substances
EP3316930B1 (de) 2015-07-03 2019-07-31 Ferrosan Medical Devices A/S Spritze zum mischen zweier komponenten und zum aufrechterhalten eines vakuums im lagerzustand
JP6148701B2 (ja) * 2015-07-31 2017-06-14 ユニベルシテ ドゥ ジュネーブ 2−ヒドロキシアルキル酸から調製されたポリマーを含む組成物
CN105111417A (zh) * 2015-08-25 2015-12-02 杭州铭众生物科技有限公司 一种羟基乙酸-羟基丙酸无规共聚物的制备方法
KR20210008479A (ko) 2018-05-09 2021-01-22 훼로산 메디칼 디바이스 에이/에스 지혈 조성물을 제조하는 방법

Citations (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US329526A (en) 1885-11-03 Coal-mining machine
US368702A (en) 1887-08-23 bischoff
US467719A (en) 1892-01-26 Dust-guard for car-axle journals
US3853837A (en) 1972-04-29 1974-12-10 Takeda Chemical Industries Ltd Novel nonapeptide amide analogs of luteinizing hormone releasing factor
JPS50121273A (de) 1973-07-02 1975-09-23
GB1423083A (en) 1973-07-24 1976-01-28 Takeda Chemical Industries Ltd Nonapeptide amides
US3972859A (en) 1974-03-08 1976-08-03 Takeda Chemical Industries, Ltd. Novel decapeptide amide analogs of leuteinizing hormone-releasing hormone
US4008209A (en) 1973-09-29 1977-02-15 Takeda Chemical Industries, Ltd. Nonapeptide amide analogs of luteinizing releasing hormone
JPS52116465A (en) 1976-03-23 1977-09-29 Takeda Chem Ind Ltd Peptides
US4086219A (en) 1975-10-29 1978-04-25 Parke, Davis & Company Nonapeptides and methods for their production
US4087390A (en) 1977-02-02 1978-05-02 Eli Lilly And Company Somatostatin analogs and intermediates thereto
US4093574A (en) 1977-02-02 1978-06-06 Eli Lilly And Company Somatostatin analogs and intermediates thereto
US4100117A (en) 1977-04-21 1978-07-11 Eli Lilly And Company Somatostatin analogs and intermediates thereto
US4121577A (en) 1977-01-03 1978-10-24 Binder Timothy A Method and apparatus for aiding conditioning of an erect spinal column and advantageous muscle control
US4253998A (en) 1979-03-09 1981-03-03 American Home Products Corporation Peptides related to somatostatin
US4253997A (en) 1979-12-17 1981-03-03 American Home Products Corporation Anti-ovulatory decapeptides
US4277394A (en) 1979-04-23 1981-07-07 Takeda Chemical Industries, Ltd Tetrapeptidehydrazide derivatives
EP0031567A2 (de) 1979-12-27 1981-07-08 Takeda Chemical Industries, Ltd. Tetrapeptidsemicarbazid-Derivate und deren Herstellung und Verwendung
US4317815A (en) 1979-06-13 1982-03-02 Coy David Howard LH-RH Antagonists
JPS6128521A (ja) 1984-07-06 1986-02-08 Wako Pure Chem Ind Ltd 新規重合体及びその製造法
JPS6254760A (ja) 1985-05-07 1987-03-10 Takeda Chem Ind Ltd ポリオキシカルボン酸エステルおよびその製造法
US4652441A (en) 1983-11-04 1987-03-24 Takeda Chemical Industries, Ltd. Prolonged release microcapsule and its production
US4683288A (en) 1984-07-06 1987-07-28 Waco Pure Chemical Ind. Inc. Polymer and its production
EP0325119A2 (de) 1988-01-19 1989-07-26 Nestor, Inc. Vorrichtung für kumulatives Lernen von internen Darstellungen in einem n-dimensionalen "Coulomb"-Netzwerk
EP0357061A1 (de) 1988-09-01 1990-03-07 Takeda Chemical Industries, Ltd. Angiogenese hemmendes Mittel
EP0359036A1 (de) 1988-09-01 1990-03-21 Takeda Chemical Industries, Ltd. Fumagillol-Derivate
JPH02212436A (ja) 1989-02-14 1990-08-23 Japan Atom Energy Res Inst 徐放性基剤
EP0415294A2 (de) 1989-08-31 1991-03-06 Takeda Chemical Industries, Ltd. Cyclohexanolderivate, ihre Herstellung und ihre Verwendung
US7411782B2 (en) 2006-03-15 2008-08-12 Hon Hai Precision Industry Co., Ltd. Computer

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4622244A (en) * 1979-09-04 1986-11-11 The Washington University Process for preparation of microcapsules
US4675189A (en) * 1980-11-18 1987-06-23 Syntex (U.S.A.) Inc. Microencapsulation of water soluble active polypeptides
PH19942A (en) * 1980-11-18 1986-08-14 Sintex Inc Microencapsulation of water soluble polypeptides
IE52535B1 (en) * 1981-02-16 1987-12-09 Ici Plc Continuous release pharmaceutical compositions
DE3218151A1 (de) * 1982-05-14 1983-11-17 Akzo Gmbh, 5600 Wuppertal Mikroporoese, pulverfoermige polylactide und verfahren zu deren herstellung
DE3678308D1 (de) * 1985-02-07 1991-05-02 Takeda Chemical Industries Ltd Verfahren zur herstellung von mikrokapseln.
US4962091A (en) * 1986-05-23 1990-10-09 Syntex (U.S.A.) Inc. Controlled release of macromolecular polypeptides
JP2526589B2 (ja) * 1986-08-08 1996-08-21 武田薬品工業株式会社 ペプチド含有マイクロカプセルおよびその製造法
JPH0725689B2 (ja) * 1986-10-07 1995-03-22 中外製薬株式会社 顆粒球コロニ−刺激因子を含有する徐放性製剤
AU606383B2 (en) * 1987-03-06 1991-02-07 Research Triangle Institute Polymer blends for selective biodegradability
JPH0613602B2 (ja) * 1987-07-14 1994-02-23 三井東圧化学株式会社 d▲l▼−乳酸−グリコール酸共重合物の製造方法
JP2827287B2 (ja) * 1988-07-05 1998-11-25 武田薬品工業株式会社 水溶性薬物含有徐放型マイクロカプセル

Patent Citations (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US368702A (en) 1887-08-23 bischoff
US467719A (en) 1892-01-26 Dust-guard for car-axle journals
US329526A (en) 1885-11-03 Coal-mining machine
US3853837A (en) 1972-04-29 1974-12-10 Takeda Chemical Industries Ltd Novel nonapeptide amide analogs of luteinizing hormone releasing factor
JPS50121273A (de) 1973-07-02 1975-09-23
GB1423083A (en) 1973-07-24 1976-01-28 Takeda Chemical Industries Ltd Nonapeptide amides
US4008209A (en) 1973-09-29 1977-02-15 Takeda Chemical Industries, Ltd. Nonapeptide amide analogs of luteinizing releasing hormone
US3972859A (en) 1974-03-08 1976-08-03 Takeda Chemical Industries, Ltd. Novel decapeptide amide analogs of leuteinizing hormone-releasing hormone
US4086219A (en) 1975-10-29 1978-04-25 Parke, Davis & Company Nonapeptides and methods for their production
JPS52116465A (en) 1976-03-23 1977-09-29 Takeda Chem Ind Ltd Peptides
US4121577A (en) 1977-01-03 1978-10-24 Binder Timothy A Method and apparatus for aiding conditioning of an erect spinal column and advantageous muscle control
US4087390A (en) 1977-02-02 1978-05-02 Eli Lilly And Company Somatostatin analogs and intermediates thereto
US4093574A (en) 1977-02-02 1978-06-06 Eli Lilly And Company Somatostatin analogs and intermediates thereto
US4100117A (en) 1977-04-21 1978-07-11 Eli Lilly And Company Somatostatin analogs and intermediates thereto
US4253998A (en) 1979-03-09 1981-03-03 American Home Products Corporation Peptides related to somatostatin
US4277394A (en) 1979-04-23 1981-07-07 Takeda Chemical Industries, Ltd Tetrapeptidehydrazide derivatives
US4317815A (en) 1979-06-13 1982-03-02 Coy David Howard LH-RH Antagonists
US4253997A (en) 1979-12-17 1981-03-03 American Home Products Corporation Anti-ovulatory decapeptides
EP0031567A2 (de) 1979-12-27 1981-07-08 Takeda Chemical Industries, Ltd. Tetrapeptidsemicarbazid-Derivate und deren Herstellung und Verwendung
US4917893A (en) 1983-11-04 1990-04-17 Takeda Chemical Industries, Ltd. Prolonged release microcapsules
US4652441A (en) 1983-11-04 1987-03-24 Takeda Chemical Industries, Ltd. Prolonged release microcapsule and its production
JPS6128521A (ja) 1984-07-06 1986-02-08 Wako Pure Chem Ind Ltd 新規重合体及びその製造法
US4683288A (en) 1984-07-06 1987-07-28 Waco Pure Chemical Ind. Inc. Polymer and its production
JPS6254760A (ja) 1985-05-07 1987-03-10 Takeda Chem Ind Ltd ポリオキシカルボン酸エステルおよびその製造法
US4849228A (en) 1985-05-07 1989-07-18 Takeda Chemical Industries, Ltd. Polymer, production and use thereof
US4728721A (en) 1985-05-07 1988-03-01 Takeda Chemical Industries, Ltd. Polymer, production and use thereof
EP0325119A2 (de) 1988-01-19 1989-07-26 Nestor, Inc. Vorrichtung für kumulatives Lernen von internen Darstellungen in einem n-dimensionalen "Coulomb"-Netzwerk
EP0357061A1 (de) 1988-09-01 1990-03-07 Takeda Chemical Industries, Ltd. Angiogenese hemmendes Mittel
EP0359036A1 (de) 1988-09-01 1990-03-21 Takeda Chemical Industries, Ltd. Fumagillol-Derivate
JPH02212436A (ja) 1989-02-14 1990-08-23 Japan Atom Energy Res Inst 徐放性基剤
EP0415294A2 (de) 1989-08-31 1991-03-06 Takeda Chemical Industries, Ltd. Cyclohexanolderivate, ihre Herstellung und ihre Verwendung
US7411782B2 (en) 2006-03-15 2008-08-12 Hon Hai Precision Industry Co., Ltd. Computer

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
FOLKMAN J, LANGER R, LINHARDT RJ, HAUDENSCHIL: "Angiogenesis inhibition and tumor regression caused by heparin or a heparin fragment in the presence of cortisone", SCIENCE, 1983, pages 719, XP000955180, DOI: doi:10.1126/science.6192498
T. W. REDDING, A. V. SCHALLY: "Inhibition of prostate tumor growth in two rat models by chronic administration of D-Trp6 analogue of luteinizing hormone-releasing hormone", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1981, pages 6509 - 6512

Also Published As

Publication number Publication date
PT99236B (pt) 1999-04-30
ZA918168B (en) 1993-04-14
US5304377A (en) 1994-04-19
UA27707C2 (uk) 2000-10-16
ES2069221T3 (es) 1995-05-01
DE69107773T2 (de) 1995-06-29
GEP19981287B (en) 1998-09-01
DK0481732T3 (da) 1995-05-22
NO914032L (no) 1992-04-21
CA2053468C (en) 2002-07-09
NZ240214A (en) 1993-02-25
NO914032D0 (no) 1991-10-14
JP3196035B2 (ja) 2001-08-06
CN1060851A (zh) 1992-05-06
CN1057670C (zh) 2000-10-25
EP0481732A1 (de) 1992-04-22
AU644019B2 (en) 1993-12-02
CA2053468A1 (en) 1992-04-17
RU2103005C1 (ru) 1998-01-27
FI101454B1 (fi) 1998-06-30
LV10055A (lv) 1994-05-10
AU8586491A (en) 1992-04-30
JPH05112468A (ja) 1993-05-07
IE913624A1 (en) 1992-04-22
LTIP442A (en) 1994-11-25
KR920007632A (ko) 1992-05-27
PT99236A (pt) 1992-09-30
CN1043189C (zh) 1999-05-05
IE66705B1 (en) 1996-01-24
CN1116212A (zh) 1996-02-07
EP0481732B1 (de) 1995-03-01
FI914865A (fi) 1992-04-17
EE02958B1 (et) 1997-02-17
FI101454B (fi) 1998-06-30
NO302481B1 (no) 1998-03-09
ATE119035T1 (de) 1995-03-15
DE69107773D1 (de) 1995-04-06
KR100199119B1 (ko) 1999-06-15
FI914865A0 (fi) 1991-10-15
MX9101595A (es) 1992-06-05
LV10055B (en) 1995-02-20

Similar Documents

Publication Publication Date Title
LT3277B (en) Prolonged release pharmaceutical preparation, polymeric composition as base for it and process for preparing thereof
EP0535937B1 (de) Mikropartikeln-Zusammenfassung zur verlängerten Freigabe und Herstellung derselbe
KR100328098B1 (ko) 수용성약제의마이크로캡슐의제조방법
KR100409413B1 (ko) 서방성제제의제조방법
KR920007831B1 (ko) 지효성(持효性)미크로 캡슐의 제조방법
EP0580428B2 (de) Mikropartikel-Zusammensetzung und Herstellung derselben
US5716640A (en) Method of producing sustained-release microcapsules
US4652441A (en) Prolonged release microcapsule and its production
CA2316159C (en) Prolonged release microcapsules
JPH08151321A (ja) 徐放剤
JPH07278277A (ja) 生体内分解性ポリマーの末端カルボキシル基におけるエステル
JP3902272B2 (ja) 徐放性製剤の製造法
JP3524195B2 (ja) 徐放性製剤用基剤

Legal Events

Date Code Title Description
MM9A Lapsed patents

Effective date: 20010319