LT3277B - Prolonged release pharmaceutical preparation, polymeric composition as base for it and process for preparing thereof - Google Patents
Prolonged release pharmaceutical preparation, polymeric composition as base for it and process for preparing thereof Download PDFInfo
- Publication number
- LT3277B LT3277B LTIP442A LTIP442A LT3277B LT 3277 B LT3277 B LT 3277B LT IP442 A LTIP442 A LT IP442A LT IP442 A LTIP442 A LT IP442A LT 3277 B LT3277 B LT 3277B
- Authority
- LT
- Lithuania
- Prior art keywords
- acid
- copolymer
- release
- microcapsules
- glycolic acid
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- 241000894007 species Species 0.000 description 1
- 150000003431 steroids Chemical class 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 125000001424 substituent group Chemical group 0.000 description 1
- YRALAIOMGQZKOW-UHFFFAOYSA-N sulfated caerulein Natural products C=1C=CC=CC=1CC(C(N)=O)NC(=O)C(CC(O)=O)NC(=O)C(CCSC)NC(=O)C(CC=1C2=CC=CC=C2NC=1)NC(=O)CNC(=O)C(C(C)O)NC(=O)C(NC(=O)C(CC(O)=O)NC(=O)C(CCC(N)=O)NC(=O)C1NC(=O)CC1)CC1=CC=C(OS(O)(=O)=O)C=C1 YRALAIOMGQZKOW-UHFFFAOYSA-N 0.000 description 1
- 229910052717 sulfur Inorganic materials 0.000 description 1
- 239000011593 sulfur Substances 0.000 description 1
- 238000001308 synthesis method Methods 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 229960004989 tetracycline hydrochloride Drugs 0.000 description 1
- 229960004072 thrombin Drugs 0.000 description 1
- LCJVIYPJPCBWKS-NXPQJCNCSA-N thymosin Chemical compound SC[C@@H](N)C(=O)N[C@H](CO)C(=O)N[C@H](CC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@H](C(C)C)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](C(C)C)C(=O)N[C@H](CO)C(=O)N[C@H](CO)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@H]([C@H](C)O)C(=O)N[C@H](C(C)C)C(=O)N[C@H](CCCCN)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@H](CCCCN)C(=O)N[C@H](CCCCN)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@H](C(C)C)C(=O)N[C@H](C(C)C)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@H](CCC(O)=O)C(O)=O LCJVIYPJPCBWKS-NXPQJCNCSA-N 0.000 description 1
- 229960003873 thymostimulin Drugs 0.000 description 1
- 230000002916 thymostimulin Effects 0.000 description 1
- 229960000707 tobramycin Drugs 0.000 description 1
- NLVFBUXFDBBNBW-PBSUHMDJSA-N tobramycin Chemical compound N[C@@H]1C[C@H](O)[C@@H](CN)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](N)[C@H](O)[C@@H](CO)O2)O)[C@H](N)C[C@@H]1N NLVFBUXFDBBNBW-PBSUHMDJSA-N 0.000 description 1
- 229960002649 tolazoline hydrochloride Drugs 0.000 description 1
- GYDJEQRTZSCIOI-LJGSYFOKSA-N tranexamic acid Chemical compound NC[C@H]1CC[C@H](C(O)=O)CC1 GYDJEQRTZSCIOI-LJGSYFOKSA-N 0.000 description 1
- 229960000401 tranexamic acid Drugs 0.000 description 1
- MWKJTNBSKNUMFN-UHFFFAOYSA-N trifluoromethyltrimethylsilane Chemical compound C[Si](C)(C)C(F)(F)F MWKJTNBSKNUMFN-UHFFFAOYSA-N 0.000 description 1
- FAPSXSAPXXJTOU-UHFFFAOYSA-L trimethyl-[6-(trimethylazaniumyl)hexyl]azanium;dibromide Chemical compound [Br-].[Br-].C[N+](C)(C)CCCCCC[N+](C)(C)C FAPSXSAPXXJTOU-UHFFFAOYSA-L 0.000 description 1
- 239000000814 tuberculostatic agent Substances 0.000 description 1
- 102000003390 tumor necrosis factor Human genes 0.000 description 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 1
- 229950009811 ubenimex Drugs 0.000 description 1
- 229960005356 urokinase Drugs 0.000 description 1
- 239000004474 valine Substances 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
- 229960003726 vasopressin Drugs 0.000 description 1
- KDQAABAKXDWYSZ-PNYVAJAMSA-N vinblastine sulfate Chemical compound OS(O)(=O)=O.C([C@H](C[C@]1(C(=O)OC)C=2C(=CC3=C([C@]45[C@H]([C@@]([C@H](OC(C)=O)[C@]6(CC)C=CCN([C@H]56)CC4)(O)C(=O)OC)N3C)C=2)OC)C[C@@](C2)(O)CC)N2CCC2=C1NC1=CC=CC=C21 KDQAABAKXDWYSZ-PNYVAJAMSA-N 0.000 description 1
- 229960004982 vinblastine sulfate Drugs 0.000 description 1
- AQTQHPDCURKLKT-JKDPCDLQSA-N vincristine sulfate Chemical compound OS(O)(=O)=O.C([C@@H](C[C@]1(C(=O)OC)C=2C(=CC3=C([C@]45[C@H]([C@@]([C@H](OC(C)=O)[C@]6(CC)C=CCN([C@H]56)CC4)(O)C(=O)OC)N3C=O)C=2)OC)C[C@@](C2)(O)CC)N2CCC2=C1NC1=CC=CC=C21 AQTQHPDCURKLKT-JKDPCDLQSA-N 0.000 description 1
- 229960002110 vincristine sulfate Drugs 0.000 description 1
- 235000012711 vitamin K3 Nutrition 0.000 description 1
- 239000011652 vitamin K3 Substances 0.000 description 1
- 229940041603 vitamin k 3 Drugs 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 229950009268 zinostatin Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
- A61K31/745—Polymers of hydrocarbons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
- A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L67/00—Compositions of polyesters obtained by reactions forming a carboxylic ester link in the main chain; Compositions of derivatives of such polymers
- C08L67/04—Polyesters derived from hydroxycarboxylic acids, e.g. lactones
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Organic Chemistry (AREA)
- Polymers & Plastics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Polyesters Or Polycarbonates (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
- Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP27803790 | 1990-10-16 | ||
| JP21704591 | 1991-08-28 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| LTIP442A LTIP442A (en) | 1994-11-25 |
| LT3277B true LT3277B (en) | 1995-05-25 |
Family
ID=26521778
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| LTIP442A LT3277B (en) | 1990-10-16 | 1993-03-19 | Prolonged release pharmaceutical preparation, polymeric composition as base for it and process for preparing thereof |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US5304377A (de) |
| EP (1) | EP0481732B1 (de) |
| JP (1) | JP3196035B2 (de) |
| KR (1) | KR100199119B1 (de) |
| CN (2) | CN1043189C (de) |
| AT (1) | ATE119035T1 (de) |
| AU (1) | AU644019B2 (de) |
| CA (1) | CA2053468C (de) |
| DE (1) | DE69107773T2 (de) |
| DK (1) | DK0481732T3 (de) |
| EE (1) | EE02958B1 (de) |
| ES (1) | ES2069221T3 (de) |
| FI (1) | FI101454B (de) |
| GE (1) | GEP19981287B (de) |
| IE (1) | IE66705B1 (de) |
| LT (1) | LT3277B (de) |
| LV (1) | LV10055B (de) |
| MX (1) | MX9101595A (de) |
| NO (1) | NO302481B1 (de) |
| NZ (1) | NZ240214A (de) |
| PT (1) | PT99236B (de) |
| RU (1) | RU2103005C1 (de) |
| UA (1) | UA27707C2 (de) |
| ZA (1) | ZA918168B (de) |
Families Citing this family (92)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6323307B1 (en) | 1988-08-08 | 2001-11-27 | Cargill Dow Polymers, Llc | Degradation control of environmentally degradable disposable materials |
| US5247059A (en) * | 1992-01-24 | 1993-09-21 | Cargill, Incorporated | Continuous process for the manufacture of a purified lactide from esters of lactic acid |
| US6005067A (en) * | 1992-01-24 | 1999-12-21 | Cargill Incorporated | Continuous process for manufacture of lactide polymers with controlled optical purity |
| US6326458B1 (en) | 1992-01-24 | 2001-12-04 | Cargill, Inc. | Continuous process for the manufacture of lactide and lactide polymers |
| US5258488A (en) * | 1992-01-24 | 1993-11-02 | Cargill, Incorporated | Continuous process for manufacture of lactide polymers with controlled optical purity |
| US5247058A (en) * | 1992-01-24 | 1993-09-21 | Cargill, Incorporated | Continuous process for manufacture of lactide polymers with controlled optical purity |
| US5142023A (en) * | 1992-01-24 | 1992-08-25 | Cargill, Incorporated | Continuous process for manufacture of lactide polymers with controlled optical purity |
| DK0615555T3 (da) * | 1992-10-02 | 2001-07-09 | Cargill Inc | Tekstilmateriale af smeltestabil lactidpolymer og fremgangsmåde til fremstilling deraf |
| ES2123668T3 (es) * | 1992-10-02 | 1999-01-16 | Cargill Inc | Papel que tiene un recubrimiento de polimero de lactida estable en estado fundido y procedimiento para su fabricacion. |
| US5338822A (en) * | 1992-10-02 | 1994-08-16 | Cargill, Incorporated | Melt-stable lactide polymer composition and process for manufacture thereof |
| US6005068A (en) * | 1992-10-02 | 1999-12-21 | Cargill Incorporated | Melt-stable amorphous lactide polymer film and process for manufacture thereof |
| TW333456B (en) * | 1992-12-07 | 1998-06-11 | Takeda Pharm Ind Co Ltd | A pharmaceutical composition of sustained-release preparation the invention relates to a pharmaceutical composition of sustained-release preparation which comprises a physiologically active peptide. |
| UA61046C2 (en) | 1992-12-07 | 2003-11-17 | Takeda Chemical Industries Ltd | Sustained-release preparation and method for its manufacture |
| US5716981A (en) * | 1993-07-19 | 1998-02-10 | Angiogenesis Technologies, Inc. | Anti-angiogenic compositions and methods of use |
| DE69435342D1 (de) | 1993-07-19 | 2011-05-05 | Angiotech Pharm Inc | Anti-Angiogene Mittel und Verfahren zu deren Verwendung |
| US5424289A (en) * | 1993-07-30 | 1995-06-13 | Alza Corporation | Solid formulations of therapeutic proteins for gastrointestinal delivery |
| US5594091A (en) * | 1994-02-21 | 1997-01-14 | Takeda Chemical Industries, Ltd. | Matrix for sustained-release preparation |
| FR2718642B1 (fr) * | 1994-04-15 | 1996-07-12 | Pf Medicament | Microsphères biodégradables à libération contrôlée et leur procédé de préparation. |
| US5626862A (en) | 1994-08-02 | 1997-05-06 | Massachusetts Institute Of Technology | Controlled local delivery of chemotherapeutic agents for treating solid tumors |
| JP2987064B2 (ja) * | 1994-09-12 | 1999-12-06 | グンゼ株式会社 | 人工硬膜 |
| US6117455A (en) * | 1994-09-30 | 2000-09-12 | Takeda Chemical Industries, Ltd. | Sustained-release microcapsule of amorphous water-soluble pharmaceutical active agent |
| DE69615763T2 (de) * | 1995-07-13 | 2002-08-08 | Mitsubishi Gas Chemical Co., Inc. | Polymermischungen aliphatischer Polyester auf Basis von Polylactiden, Verfahren zu deren Herstellung und Verfahren zum Formen diese Mischungen |
| EP0765660A3 (de) * | 1995-09-28 | 1998-09-23 | Takeda Chemical Industries, Ltd. | Mikrokapseln enthaltend 2-Piperazinon-1-essigsäure Verbindungen |
| US5637085A (en) * | 1995-11-20 | 1997-06-10 | Cardinale; Robert M. | Method of cancer tumor treatment by slow release delivery of 1,2,4-benzotriazine oxides to tumor site |
| DE19545257A1 (de) | 1995-11-24 | 1997-06-19 | Schering Ag | Verfahren zur Herstellung von morphologisch einheitlichen Mikrokapseln sowie nach diesem Verfahren hergestellte Mikrokapseln |
| CA2192782C (en) | 1995-12-15 | 2008-10-14 | Nobuyuki Takechi | Production of microspheres |
| FR2744367B1 (fr) * | 1996-02-02 | 1999-07-09 | Emperaire Jean Claude | Medicaments pour le declenchement de l'ovulation |
| DE69717263T2 (de) * | 1996-03-28 | 2003-07-24 | Takeda Chemical Industries, Ltd. | Zubereitung mit verzögerter freisetzung und deren herstellung |
| DK0914102T3 (da) | 1996-05-24 | 2006-01-09 | Angiotech Pharm Inc | Præparater og fremgangsmåder til behandling eller forebyggelse af syddomme i legemskanaler |
| JP4317599B2 (ja) * | 1996-06-26 | 2009-08-19 | 武田薬品工業株式会社 | 徐放性製剤 |
| US8603511B2 (en) | 1996-08-27 | 2013-12-10 | Baxter International, Inc. | Fragmented polymeric compositions and methods for their use |
| US8303981B2 (en) | 1996-08-27 | 2012-11-06 | Baxter International Inc. | Fragmented polymeric compositions and methods for their use |
| US6066325A (en) * | 1996-08-27 | 2000-05-23 | Fusion Medical Technologies, Inc. | Fragmented polymeric compositions and methods for their use |
| US7435425B2 (en) * | 2001-07-17 | 2008-10-14 | Baxter International, Inc. | Dry hemostatic compositions and methods for their preparation |
| US7871637B2 (en) | 1996-08-27 | 2011-01-18 | Baxter International Inc. | Dry hemostatic compositions and methods for their preparation |
| US7235524B2 (en) * | 1997-01-31 | 2007-06-26 | Applied Research System Ars Holding N.V. | Medicaments for initiating ovulation |
| US5945126A (en) * | 1997-02-13 | 1999-08-31 | Oakwood Laboratories L.L.C. | Continuous microsphere process |
| IL132120A0 (en) | 1997-04-03 | 2001-03-19 | Guilford Pharm Inc | Biodegradable terephthalate polyester-poly (phosphate) polymers compositions articles and methods for making and using the same |
| US6051558A (en) * | 1997-05-28 | 2000-04-18 | Southern Biosystems, Inc. | Compositions suitable for controlled release of the hormone GnRH and its analogs |
| US6162241A (en) * | 1997-08-06 | 2000-12-19 | Focal, Inc. | Hemostatic tissue sealants |
| KR19990065921A (ko) * | 1998-01-19 | 1999-08-16 | 김충섭 | 항생제의서방성제제 |
| US6099859A (en) * | 1998-03-20 | 2000-08-08 | Andrx Pharmaceuticals, Inc. | Controlled release oral tablet having a unitary core |
| US6153212A (en) * | 1998-10-02 | 2000-11-28 | Guilford Pharmaceuticals Inc. | Biodegradable terephthalate polyester-poly (phosphonate) compositions, articles, and methods of using the same |
| US6419709B1 (en) | 1998-10-02 | 2002-07-16 | Guilford Pharmaceuticals, Inc. | Biodegradable terephthalate polyester-poly(Phosphite) compositions, articles, and methods of using the same |
| US6270802B1 (en) | 1998-10-28 | 2001-08-07 | Oakwood Laboratories L.L.C. | Method and apparatus for formulating microspheres and microcapsules |
| GB2344287A (en) * | 1998-12-03 | 2000-06-07 | Ferring Bv | Controlled release pharmaceutical formulation |
| BR9916117A (pt) * | 1998-12-15 | 2001-09-04 | Wolff Walsrode Ag | Corpos moldados termoplásticos, biodegradáveis, exibindo uma estabilidade melhorada com respeito à hidrólise e uma resistência melhorada à rachadura por tensão |
| US6350464B1 (en) | 1999-01-11 | 2002-02-26 | Guilford Pharmaceuticals, Inc. | Methods for treating ovarian cancer, poly (phosphoester) compositions, and biodegradable articles for same |
| US6537585B1 (en) | 1999-03-26 | 2003-03-25 | Guilford Pharmaceuticals, Inc. | Methods and compositions for treating solid tumors |
| AU2002232824A1 (en) | 2000-12-21 | 2002-07-01 | Inhale Therapeutic Systems, Inc. | Induced phase transition method for the production of microparticles containing hydrophobic active agents |
| CN1098883C (zh) * | 2000-12-28 | 2003-01-15 | 武汉大学 | 分散度均匀的聚乳酸微球制备新方法 |
| CA2451187C (en) | 2001-06-22 | 2012-08-14 | Southern Biosystems, Inc. | Zero-order prolonged release coaxial implants |
| WO2003007782A2 (en) | 2001-06-29 | 2003-01-30 | Medgraft Microtech, Inc. | Biodegradable injectable implants and related methods of manufacture and use |
| JP2003192773A (ja) * | 2001-12-26 | 2003-07-09 | Mitsui Chemicals Inc | 生体吸収性ポリヒドロキシカルボン酸及びその製造法 |
| AU2002367105A1 (en) * | 2001-12-26 | 2003-07-15 | Takeda Chemical Industries, Ltd. | Novel microsphere and method for production thereof |
| US20040197301A1 (en) * | 2003-02-18 | 2004-10-07 | Zhong Zhao | Hybrid polymers and methods of making the same |
| US8834864B2 (en) * | 2003-06-05 | 2014-09-16 | Baxter International Inc. | Methods for repairing and regenerating human dura mater |
| US7927626B2 (en) * | 2003-08-07 | 2011-04-19 | Ethicon, Inc. | Process of making flowable hemostatic compositions and devices containing such compositions |
| US7645459B2 (en) | 2004-05-24 | 2010-01-12 | The Procter & Gamble Company | Dosage forms of bisphosphonates |
| US7645460B2 (en) * | 2004-05-24 | 2010-01-12 | The Procter & Gamble Company | Dosage forms of risedronate |
| US20080287400A1 (en) * | 2004-05-24 | 2008-11-20 | Richard John Dansereau | Low Dosage Forms Of Risedronate Or Its Salts |
| US20080286359A1 (en) * | 2004-05-24 | 2008-11-20 | Richard John Dansereau | Low Dosage Forms Of Risedronate Or Its Salts |
| US20090275730A1 (en) * | 2004-10-20 | 2009-11-05 | Hiroyuki Oku | Temperature responsive depsipeptide polymer |
| CN1923281B (zh) * | 2005-08-30 | 2010-05-05 | 孔庆忠 | 一种含植物生物碱的抗癌缓释注射剂 |
| EP1986603A2 (de) * | 2006-01-13 | 2008-11-05 | SurModics, Inc. | Mikropartikel mit matrizen für die arzneimittelabgabe |
| BRPI0712088B8 (pt) * | 2006-05-31 | 2021-06-22 | Baxter Healthcare Sa | uso de uma biomatriz de lâmina de colágeno de múltiplas camadas microscópicas não porosa e hermética a fluido |
| TWI436793B (zh) * | 2006-08-02 | 2014-05-11 | Baxter Int | 快速作用之乾密封膠及其使用和製造方法 |
| KR100845009B1 (ko) * | 2007-08-07 | 2008-07-08 | 한국생명공학연구원 | 전하를 띠는 물질이 고착된 다공성 고분자 입자 및 그제조방법 |
| CA2703103C (en) | 2007-10-30 | 2017-05-09 | Baxter Healthcare S.A. | Use of a regenerative biofunctional collagen biomatrix for treating visceral or parietal defects |
| EP2259803B2 (de) | 2008-02-29 | 2019-03-13 | Ferrosan Medical Devices A/S | Vorrichtung zur förderung von hämostase und/oder wundheilung |
| US9039783B2 (en) * | 2009-05-18 | 2015-05-26 | Baxter International, Inc. | Method for the improvement of mesh implant biocompatibility |
| CN102802683B (zh) * | 2009-06-16 | 2015-11-25 | 巴克斯特国际公司 | 止血海绵 |
| WO2011024944A1 (ja) * | 2009-08-31 | 2011-03-03 | 国立大学法人豊橋技術科学大学 | ステレオコンプレックスポリエステル及びその製造方法 |
| US8771258B2 (en) | 2009-12-16 | 2014-07-08 | Baxter International Inc. | Hemostatic sponge |
| SA111320355B1 (ar) | 2010-04-07 | 2015-01-08 | Baxter Heathcare S A | إسفنجة لايقاف النزف |
| JP6289096B2 (ja) | 2010-06-01 | 2018-03-07 | バクスター・インターナショナル・インコーポレイテッドＢａｘｔｅｒ Ｉｎｔｅｒｎａｔｉｏｎａｌ Ｉｎｃｏｒｐ０Ｒａｔｅｄ | 乾燥した安定な止血組成物を作製するためのプロセス |
| MX345479B (es) | 2010-06-01 | 2017-02-01 | Baxter Int Inc * | Proceso para elaborar composiciones hemostaticas secas y estables. |
| BR112012030455B1 (pt) | 2010-06-01 | 2021-08-17 | Baxter Healthcare S.A. | Processo para fabricar uma composição hemostática seca e estável, recipiente acabado final, e, kit para administrar uma composição hemostática |
| WO2012014011A1 (en) | 2010-07-26 | 2012-02-02 | Universite De Geneve | Compositions comprising polymers prepared from 2-hydroxyalkyl acids |
| KR102135484B1 (ko) | 2011-10-11 | 2020-07-20 | 백스터 인터내셔널 인코포레이티드 | 지혈 조성물 |
| WO2013053759A2 (en) | 2011-10-11 | 2013-04-18 | Baxter International Inc. | Hemostatic compositions |
| SA112330957B1 (ar) | 2011-10-27 | 2015-08-09 | باكستر انترناشونال انك. | تركيبات لإيقاف النزف |
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Citations (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US329526A (en) | 1885-11-03 | Coal-mining machine | ||
| US368702A (en) | 1887-08-23 | bischoff | ||
| US467719A (en) | 1892-01-26 | Dust-guard for car-axle journals | ||
| US3853837A (en) | 1972-04-29 | 1974-12-10 | Takeda Chemical Industries Ltd | Novel nonapeptide amide analogs of luteinizing hormone releasing factor |
| JPS50121273A (de) | 1973-07-02 | 1975-09-23 | ||
| GB1423083A (en) | 1973-07-24 | 1976-01-28 | Takeda Chemical Industries Ltd | Nonapeptide amides |
| US3972859A (en) | 1974-03-08 | 1976-08-03 | Takeda Chemical Industries, Ltd. | Novel decapeptide amide analogs of leuteinizing hormone-releasing hormone |
| US4008209A (en) | 1973-09-29 | 1977-02-15 | Takeda Chemical Industries, Ltd. | Nonapeptide amide analogs of luteinizing releasing hormone |
| JPS52116465A (en) | 1976-03-23 | 1977-09-29 | Takeda Chem Ind Ltd | Peptides |
| US4086219A (en) | 1975-10-29 | 1978-04-25 | Parke, Davis & Company | Nonapeptides and methods for their production |
| US4087390A (en) | 1977-02-02 | 1978-05-02 | Eli Lilly And Company | Somatostatin analogs and intermediates thereto |
| US4093574A (en) | 1977-02-02 | 1978-06-06 | Eli Lilly And Company | Somatostatin analogs and intermediates thereto |
| US4100117A (en) | 1977-04-21 | 1978-07-11 | Eli Lilly And Company | Somatostatin analogs and intermediates thereto |
| US4121577A (en) | 1977-01-03 | 1978-10-24 | Binder Timothy A | Method and apparatus for aiding conditioning of an erect spinal column and advantageous muscle control |
| US4253998A (en) | 1979-03-09 | 1981-03-03 | American Home Products Corporation | Peptides related to somatostatin |
| US4253997A (en) | 1979-12-17 | 1981-03-03 | American Home Products Corporation | Anti-ovulatory decapeptides |
| US4277394A (en) | 1979-04-23 | 1981-07-07 | Takeda Chemical Industries, Ltd | Tetrapeptidehydrazide derivatives |
| EP0031567A2 (de) | 1979-12-27 | 1981-07-08 | Takeda Chemical Industries, Ltd. | Tetrapeptidsemicarbazid-Derivate und deren Herstellung und Verwendung |
| US4317815A (en) | 1979-06-13 | 1982-03-02 | Coy David Howard | LH-RH Antagonists |
| JPS6128521A (ja) | 1984-07-06 | 1986-02-08 | Wako Pure Chem Ind Ltd | 新規重合体及びその製造法 |
| JPS6254760A (ja) | 1985-05-07 | 1987-03-10 | Takeda Chem Ind Ltd | ポリオキシカルボン酸エステルおよびその製造法 |
| US4652441A (en) | 1983-11-04 | 1987-03-24 | Takeda Chemical Industries, Ltd. | Prolonged release microcapsule and its production |
| US4683288A (en) | 1984-07-06 | 1987-07-28 | Waco Pure Chemical Ind. Inc. | Polymer and its production |
| EP0325119A2 (de) | 1988-01-19 | 1989-07-26 | Nestor, Inc. | Vorrichtung für kumulatives Lernen von internen Darstellungen in einem n-dimensionalen "Coulomb"-Netzwerk |
| EP0357061A1 (de) | 1988-09-01 | 1990-03-07 | Takeda Chemical Industries, Ltd. | Angiogenese hemmendes Mittel |
| EP0359036A1 (de) | 1988-09-01 | 1990-03-21 | Takeda Chemical Industries, Ltd. | Fumagillol-Derivate |
| JPH02212436A (ja) | 1989-02-14 | 1990-08-23 | Japan Atom Energy Res Inst | 徐放性基剤 |
| EP0415294A2 (de) | 1989-08-31 | 1991-03-06 | Takeda Chemical Industries, Ltd. | Cyclohexanolderivate, ihre Herstellung und ihre Verwendung |
| US7411782B2 (en) | 2006-03-15 | 2008-08-12 | Hon Hai Precision Industry Co., Ltd. | Computer |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4622244A (en) * | 1979-09-04 | 1986-11-11 | The Washington University | Process for preparation of microcapsules |
| US4675189A (en) * | 1980-11-18 | 1987-06-23 | Syntex (U.S.A.) Inc. | Microencapsulation of water soluble active polypeptides |
| PH19942A (en) * | 1980-11-18 | 1986-08-14 | Sintex Inc | Microencapsulation of water soluble polypeptides |
| IE52535B1 (en) * | 1981-02-16 | 1987-12-09 | Ici Plc | Continuous release pharmaceutical compositions |
| DE3218151A1 (de) * | 1982-05-14 | 1983-11-17 | Akzo Gmbh, 5600 Wuppertal | Mikroporoese, pulverfoermige polylactide und verfahren zu deren herstellung |
| DE3678308D1 (de) * | 1985-02-07 | 1991-05-02 | Takeda Chemical Industries Ltd | Verfahren zur herstellung von mikrokapseln. |
| US4962091A (en) * | 1986-05-23 | 1990-10-09 | Syntex (U.S.A.) Inc. | Controlled release of macromolecular polypeptides |
| JP2526589B2 (ja) * | 1986-08-08 | 1996-08-21 | 武田薬品工業株式会社 | ペプチド含有マイクロカプセルおよびその製造法 |
| JPH0725689B2 (ja) * | 1986-10-07 | 1995-03-22 | 中外製薬株式会社 | 顆粒球コロニ−刺激因子を含有する徐放性製剤 |
| AU606383B2 (en) * | 1987-03-06 | 1991-02-07 | Research Triangle Institute | Polymer blends for selective biodegradability |
| JPH0613602B2 (ja) * | 1987-07-14 | 1994-02-23 | 三井東圧化学株式会社 | ｄ▲ｌ▼−乳酸−グリコール酸共重合物の製造方法 |
| JP2827287B2 (ja) * | 1988-07-05 | 1998-11-25 | 武田薬品工業株式会社 | 水溶性薬物含有徐放型マイクロカプセル |
-
1991
- 1991-10-14 NZ NZ240214A patent/NZ240214A/xx unknown
- 1991-10-14 NO NO914032A patent/NO302481B1/no not_active IP Right Cessation
- 1991-10-14 ZA ZA918168A patent/ZA918168B/xx unknown
- 1991-10-15 MX MX9101595A patent/MX9101595A/es not_active IP Right Cessation
- 1991-10-15 DK DK91309490.0T patent/DK0481732T3/da active
- 1991-10-15 FI FI914865A patent/FI101454B/fi active
- 1991-10-15 RU SU5010042A patent/RU2103005C1/ru active
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- 1991-10-15 DE DE69107773T patent/DE69107773T2/de not_active Expired - Lifetime
- 1991-10-15 ES ES91309490T patent/ES2069221T3/es not_active Expired - Lifetime
- 1991-10-15 AU AU85864/91A patent/AU644019B2/en not_active Ceased
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- 1991-10-15 EP EP91309490A patent/EP0481732B1/de not_active Expired - Lifetime
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- 1991-10-16 JP JP26792991A patent/JP3196035B2/ja not_active Expired - Fee Related
-
1992
- 1992-12-07 US US07/986,299 patent/US5304377A/en not_active Expired - Lifetime
- 1992-12-30 LV LVP-92-573A patent/LV10055B/lv unknown
-
1993
- 1993-03-11 GE GEAP1993605A patent/GEP19981287B/en unknown
- 1993-03-19 LT LTIP442A patent/LT3277B/lt not_active IP Right Cessation
-
1994
- 1994-11-17 EE EE9400413A patent/EE02958B1/xx unknown
-
1995
- 1995-03-10 CN CN95102413A patent/CN1057670C/zh not_active Expired - Fee Related
Patent Citations (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US368702A (en) | 1887-08-23 | bischoff | ||
| US467719A (en) | 1892-01-26 | Dust-guard for car-axle journals | ||
| US329526A (en) | 1885-11-03 | Coal-mining machine | ||
| US3853837A (en) | 1972-04-29 | 1974-12-10 | Takeda Chemical Industries Ltd | Novel nonapeptide amide analogs of luteinizing hormone releasing factor |
| JPS50121273A (de) | 1973-07-02 | 1975-09-23 | ||
| GB1423083A (en) | 1973-07-24 | 1976-01-28 | Takeda Chemical Industries Ltd | Nonapeptide amides |
| US4008209A (en) | 1973-09-29 | 1977-02-15 | Takeda Chemical Industries, Ltd. | Nonapeptide amide analogs of luteinizing releasing hormone |
| US3972859A (en) | 1974-03-08 | 1976-08-03 | Takeda Chemical Industries, Ltd. | Novel decapeptide amide analogs of leuteinizing hormone-releasing hormone |
| US4086219A (en) | 1975-10-29 | 1978-04-25 | Parke, Davis & Company | Nonapeptides and methods for their production |
| JPS52116465A (en) | 1976-03-23 | 1977-09-29 | Takeda Chem Ind Ltd | Peptides |
| US4121577A (en) | 1977-01-03 | 1978-10-24 | Binder Timothy A | Method and apparatus for aiding conditioning of an erect spinal column and advantageous muscle control |
| US4087390A (en) | 1977-02-02 | 1978-05-02 | Eli Lilly And Company | Somatostatin analogs and intermediates thereto |
| US4093574A (en) | 1977-02-02 | 1978-06-06 | Eli Lilly And Company | Somatostatin analogs and intermediates thereto |
| US4100117A (en) | 1977-04-21 | 1978-07-11 | Eli Lilly And Company | Somatostatin analogs and intermediates thereto |
| US4253998A (en) | 1979-03-09 | 1981-03-03 | American Home Products Corporation | Peptides related to somatostatin |
| US4277394A (en) | 1979-04-23 | 1981-07-07 | Takeda Chemical Industries, Ltd | Tetrapeptidehydrazide derivatives |
| US4317815A (en) | 1979-06-13 | 1982-03-02 | Coy David Howard | LH-RH Antagonists |
| US4253997A (en) | 1979-12-17 | 1981-03-03 | American Home Products Corporation | Anti-ovulatory decapeptides |
| EP0031567A2 (de) | 1979-12-27 | 1981-07-08 | Takeda Chemical Industries, Ltd. | Tetrapeptidsemicarbazid-Derivate und deren Herstellung und Verwendung |
| US4917893A (en) | 1983-11-04 | 1990-04-17 | Takeda Chemical Industries, Ltd. | Prolonged release microcapsules |
| US4652441A (en) | 1983-11-04 | 1987-03-24 | Takeda Chemical Industries, Ltd. | Prolonged release microcapsule and its production |
| JPS6128521A (ja) | 1984-07-06 | 1986-02-08 | Wako Pure Chem Ind Ltd | 新規重合体及びその製造法 |
| US4683288A (en) | 1984-07-06 | 1987-07-28 | Waco Pure Chemical Ind. Inc. | Polymer and its production |
| JPS6254760A (ja) | 1985-05-07 | 1987-03-10 | Takeda Chem Ind Ltd | ポリオキシカルボン酸エステルおよびその製造法 |
| US4849228A (en) | 1985-05-07 | 1989-07-18 | Takeda Chemical Industries, Ltd. | Polymer, production and use thereof |
| US4728721A (en) | 1985-05-07 | 1988-03-01 | Takeda Chemical Industries, Ltd. | Polymer, production and use thereof |
| EP0325119A2 (de) | 1988-01-19 | 1989-07-26 | Nestor, Inc. | Vorrichtung für kumulatives Lernen von internen Darstellungen in einem n-dimensionalen "Coulomb"-Netzwerk |
| EP0357061A1 (de) | 1988-09-01 | 1990-03-07 | Takeda Chemical Industries, Ltd. | Angiogenese hemmendes Mittel |
| EP0359036A1 (de) | 1988-09-01 | 1990-03-21 | Takeda Chemical Industries, Ltd. | Fumagillol-Derivate |
| JPH02212436A (ja) | 1989-02-14 | 1990-08-23 | Japan Atom Energy Res Inst | 徐放性基剤 |
| EP0415294A2 (de) | 1989-08-31 | 1991-03-06 | Takeda Chemical Industries, Ltd. | Cyclohexanolderivate, ihre Herstellung und ihre Verwendung |
| US7411782B2 (en) | 2006-03-15 | 2008-08-12 | Hon Hai Precision Industry Co., Ltd. | Computer |
Non-Patent Citations (2)
| Title |
|---|
| FOLKMAN J, LANGER R, LINHARDT RJ, HAUDENSCHIL: "Angiogenesis inhibition and tumor regression caused by heparin or a heparin fragment in the presence of cortisone", SCIENCE, 1983, pages 719, XP000955180, DOI: doi:10.1126/science.6192498 |
| T. W. REDDING, A. V. SCHALLY: "Inhibition of prostate tumor growth in two rat models by chronic administration of D-Trp6 analogue of luteinizing hormone-releasing hormone", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1981, pages 6509 - 6512 |
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