KR890006593A - 아르마타제 억제4(5)- 이미다졸 - Google Patents
아르마타제 억제4(5)- 이미다졸 Download PDFInfo
- Publication number
- KR890006593A KR890006593A KR1019880013196A KR880013196A KR890006593A KR 890006593 A KR890006593 A KR 890006593A KR 1019880013196 A KR1019880013196 A KR 1019880013196A KR 880013196 A KR880013196 A KR 880013196A KR 890006593 A KR890006593 A KR 890006593A
- Authority
- KR
- South Korea
- Prior art keywords
- imidazole
- bis
- benzyl
- propyl
- propen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Substances C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 title claims 35
- 230000005764 inhibitory process Effects 0.000 title 1
- 150000002460 imidazoles Chemical class 0.000 claims 9
- -1 2,6-dimethylphenyl Chemical group 0.000 claims 6
- 229910052736 halogen Inorganic materials 0.000 claims 5
- 150000002367 halogens Chemical class 0.000 claims 5
- 239000002253 acid Substances 0.000 claims 4
- 231100000252 nontoxic Toxicity 0.000 claims 4
- 230000003000 nontoxic effect Effects 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 4
- 150000001875 compounds Chemical class 0.000 claims 3
- 125000000040 m-tolyl group Chemical group [H]C1=C([H])C(*)=C([H])C(=C1[H])C([H])([H])[H] 0.000 claims 3
- 125000003261 o-tolyl group Chemical group [H]C1=C([H])C(*)=C(C([H])=C1[H])C([H])([H])[H] 0.000 claims 3
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims 3
- ZNOZFEFFMRMISV-UHFFFAOYSA-N 5-[3,3-bis(3,5-dimethylphenyl)propyl]-1h-imidazole Chemical compound CC1=CC(C)=CC(C(CCC=2N=CNC=2)C=2C=C(C)C=C(C)C=2)=C1 ZNOZFEFFMRMISV-UHFFFAOYSA-N 0.000 claims 2
- QQONPFPTGQHPMA-UHFFFAOYSA-N Propene Chemical compound CC=C QQONPFPTGQHPMA-UHFFFAOYSA-N 0.000 claims 2
- 125000003854 p-chlorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1Cl 0.000 claims 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 2
- GUDQPRHRGNSLRL-UHFFFAOYSA-N 1-(4-chlorophenyl)-3-(1h-imidazol-5-yl)-1-phenylpropan-1-ol Chemical compound C=1C=CC=CC=1C(C=1C=CC(Cl)=CC=1)(O)CCC1=CNC=N1 GUDQPRHRGNSLRL-UHFFFAOYSA-N 0.000 claims 1
- OSEXTGSEVIILPG-UHFFFAOYSA-N 1-[(4-chlorophenyl)methyl]-4-(3,3-diphenylpropyl)imidazole Chemical compound C1=CC(Cl)=CC=C1CN1C=C(CCC(C=2C=CC=CC=2)C=2C=CC=CC=2)N=C1 OSEXTGSEVIILPG-UHFFFAOYSA-N 0.000 claims 1
- RYFDLXUXRKVOJC-UHFFFAOYSA-N 1-[(4-chlorophenyl)methyl]-5-(3,3-diphenylpropyl)imidazole Chemical compound C1=CC(Cl)=CC=C1CN1C(CCC(C=2C=CC=CC=2)C=2C=CC=CC=2)=CN=C1 RYFDLXUXRKVOJC-UHFFFAOYSA-N 0.000 claims 1
- KITCWNRQRMFSAE-UHFFFAOYSA-N 1-benzyl-5-(3,3-diphenylpropyl)imidazole Chemical compound C=1C=CC=CC=1C(C=1C=CC=CC=1)CCC1=CN=CN1CC1=CC=CC=C1 KITCWNRQRMFSAE-UHFFFAOYSA-N 0.000 claims 1
- XDAIFTMARUITOK-UHFFFAOYSA-N 2-(4-methoxyphenyl)-1-propylimidazole Chemical compound COC1=CC=C(C=C1)C=1N(C=CN1)CCC XDAIFTMARUITOK-UHFFFAOYSA-N 0.000 claims 1
- 125000004204 2-methoxyphenyl group Chemical group [H]C1=C([H])C(*)=C(OC([H])([H])[H])C([H])=C1[H] 0.000 claims 1
- XYYODYAKXUCSQI-UHFFFAOYSA-N 3-(3-benzylimidazol-4-yl)-1,1-bis(3,5-dimethylphenyl)propan-1-ol Chemical compound CC1=CC(C)=CC(C(O)(CCC=2N(C=NC=2)CC=2C=CC=CC=2)C=2C=C(C)C=C(C)C=2)=C1 XYYODYAKXUCSQI-UHFFFAOYSA-N 0.000 claims 1
- YWZTXESYYIUWOO-UHFFFAOYSA-N 3-(3-benzylimidazol-4-yl)-1,1-bis(4-chlorophenyl)propan-1-ol Chemical compound C=1C=C(Cl)C=CC=1C(C=1C=CC(Cl)=CC=1)(O)CCC1=CN=CN1CC1=CC=CC=C1 YWZTXESYYIUWOO-UHFFFAOYSA-N 0.000 claims 1
- 125000004180 3-fluorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C(F)=C1[H] 0.000 claims 1
- 125000004207 3-methoxyphenyl group Chemical group [H]C1=C([H])C(*)=C([H])C(OC([H])([H])[H])=C1[H] 0.000 claims 1
- 125000004172 4-methoxyphenyl group Chemical group [H]C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1* 0.000 claims 1
- RESAAGYDFKWKFP-UHFFFAOYSA-N 5-(3,3-diphenylprop-1-en-2-yl)-1h-imidazole Chemical compound C=1NC=NC=1C(=C)C(C=1C=CC=CC=1)C1=CC=CC=C1 RESAAGYDFKWKFP-UHFFFAOYSA-N 0.000 claims 1
- XKRRHSSIBUFZPJ-UHFFFAOYSA-N 5-(3,3-diphenylpropyl)-1h-imidazole Chemical compound C=1C=CC=CC=1C(C=1C=CC=CC=1)CCC1=CNC=N1 XKRRHSSIBUFZPJ-UHFFFAOYSA-N 0.000 claims 1
- LKPKZUIBNIUCLS-UHFFFAOYSA-N 5-[3,3-bis(2,3-dimethylphenyl)propyl]-1h-imidazole Chemical compound CC1=CC=CC(C(CCC=2N=CNC=2)C=2C(=C(C)C=CC=2)C)=C1C LKPKZUIBNIUCLS-UHFFFAOYSA-N 0.000 claims 1
- LOMUAEFYLMDOBR-UHFFFAOYSA-N 5-[3,3-bis(2-methoxyphenyl)propyl]-1h-imidazole Chemical compound COC1=CC=CC=C1C(C=1C(=CC=CC=1)OC)CCC1=CNC=N1 LOMUAEFYLMDOBR-UHFFFAOYSA-N 0.000 claims 1
- QZBYGBAZOZHGFB-UHFFFAOYSA-N 5-[3,3-bis(2-methylphenyl)propyl]-1h-imidazole Chemical compound CC1=CC=CC=C1C(C=1C(=CC=CC=1)C)CCC1=CNC=N1 QZBYGBAZOZHGFB-UHFFFAOYSA-N 0.000 claims 1
- YKODNVUQJCBYIA-UHFFFAOYSA-N 5-[3,3-bis(3-methoxyphenyl)propyl]-1h-imidazole Chemical compound COC1=CC=CC(C(CCC=2N=CNC=2)C=2C=C(OC)C=CC=2)=C1 YKODNVUQJCBYIA-UHFFFAOYSA-N 0.000 claims 1
- GBXOEZIBSXRVMX-UHFFFAOYSA-N 5-[3,3-bis(3-methylphenyl)prop-1-en-2-yl]-1h-imidazole Chemical compound CC1=CC=CC(C(C(=C)C=2N=CNC=2)C=2C=C(C)C=CC=2)=C1 GBXOEZIBSXRVMX-UHFFFAOYSA-N 0.000 claims 1
- GNCKACFWLLJVLO-UHFFFAOYSA-N 5-[3,3-bis(4-methoxyphenyl)propyl]-1h-imidazole Chemical compound C1=CC(OC)=CC=C1C(C=1C=CC(OC)=CC=1)CCC1=CNC=N1 GNCKACFWLLJVLO-UHFFFAOYSA-N 0.000 claims 1
- MMFCVWVKQOXREF-UHFFFAOYSA-N 5-[5-(2,6-dimethylphenyl)-3-[2-(2,6-dimethylphenyl)ethyl]pentyl]-1h-imidazole Chemical compound CC1=CC=CC(C)=C1CCC(CCC=1C(=CC=CC=1C)C)CCC1=CNC=N1 MMFCVWVKQOXREF-UHFFFAOYSA-N 0.000 claims 1
- 229940122815 Aromatase inhibitor Drugs 0.000 claims 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- 125000003342 alkenyl group Chemical group 0.000 claims 1
- 239000003886 aromatase inhibitor Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 229910052739 hydrogen Inorganic materials 0.000 claims 1
- 239000001257 hydrogen Substances 0.000 claims 1
- 150000002466 imines Chemical class 0.000 claims 1
- 125000001037 p-tolyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1*)C([H])([H])[H] 0.000 claims 1
- 125000001147 pentyl group Chemical group C(CCCC)* 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 125000001424 substituent group Chemical group 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB8723715A GB2210875B (en) | 1987-10-09 | 1987-10-09 | Aromatase inhibiting 4(5)-imidazoles |
| GB8723715 | 1987-10-09 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR890006593A true KR890006593A (ko) | 1989-06-14 |
Family
ID=10625036
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1019880013196A Ceased KR890006593A (ko) | 1987-10-09 | 1988-10-08 | 아르마타제 억제4(5)- 이미다졸 |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US5098923A (en, 2012) |
| EP (1) | EP0311447B1 (en, 2012) |
| JP (1) | JPH01132568A (en, 2012) |
| KR (1) | KR890006593A (en, 2012) |
| CN (1) | CN1036993C (en, 2012) |
| AU (1) | AU615482B2 (en, 2012) |
| CA (1) | CA1329616C (en, 2012) |
| DD (1) | DD282912A5 (en, 2012) |
| DE (1) | DE3874073T2 (en, 2012) |
| DK (1) | DK550988A (en, 2012) |
| ES (1) | ES2043839T3 (en, 2012) |
| FI (1) | FI93105C (en, 2012) |
| GB (1) | GB2210875B (en, 2012) |
| GR (1) | GR3006343T3 (en, 2012) |
| HU (1) | HU201024B (en, 2012) |
| IE (1) | IE61180B1 (en, 2012) |
| IL (1) | IL87969A (en, 2012) |
| LT (1) | LT3658B (en, 2012) |
| NO (1) | NO172048C (en, 2012) |
| NZ (1) | NZ226483A (en, 2012) |
| PT (1) | PT88717B (en, 2012) |
| RU (2) | RU1819263C (en, 2012) |
| UA (1) | UA13218A (en, 2012) |
| ZA (1) | ZA887545B (en, 2012) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2210875B (en) | 1987-10-09 | 1991-05-29 | Farmos Oy | Aromatase inhibiting 4(5)-imidazoles |
| GB8818561D0 (en) * | 1988-08-04 | 1988-09-07 | Ici Plc | Diphenylethane derivatives |
| JPH032168A (ja) * | 1989-03-30 | 1991-01-08 | Farmos Yhtymae Oy | アロマターゼ阻害活性を有する新規な４（５）―イミダゾール |
| US5439928A (en) * | 1989-03-30 | 1995-08-08 | Orion-Yhtyma Oy | Aromatase inhibiting 4(5)-imidazoles |
| GB2229719B (en) | 1989-03-30 | 1992-04-29 | Farmos Oy | Novel aromatase inhibiting 4(5)-imidazoles |
| GB2248058B (en) | 1990-09-21 | 1994-09-14 | Orion Yhtymae Oy | Aromatase inhibiting 4(5)-imidazoles |
| GB9125924D0 (en) * | 1991-06-18 | 1992-02-05 | Orion Yhtymae Oy | Stereoisomers of an imidazole derivative |
| ZA962879B (en) * | 1995-04-12 | 1997-03-17 | Procter & Gamble | A pharmaceutical composition for inhibiting the growth of viruses and cancers |
| US6479526B1 (en) | 1995-04-12 | 2002-11-12 | The Procter & Gamble Company | Pharmaceutical composition for inhibiting the growth of viruses and cancers |
| US6262093B1 (en) | 1995-04-12 | 2001-07-17 | The Proctor & Gamble Company | Methods of treating cancer with benzimidazoles |
| US6265427B1 (en) | 1995-06-07 | 2001-07-24 | The Proctor & Gamble Company | Pharmaceutical composition for the method of treating leukemia |
| AU1529997A (en) * | 1996-01-16 | 1997-08-11 | Warner-Lambert Company | Substituted histidine inhibitors of protein farnesyltransferase |
| US5900429A (en) | 1997-01-28 | 1999-05-04 | The Procter & Gamble Company | Method for inhibiting the growth of cancers |
| US6506783B1 (en) | 1997-05-16 | 2003-01-14 | The Procter & Gamble Company | Cancer treatments and pharmaceutical compositions therefor |
| CA2301032C (en) * | 1997-08-15 | 2009-01-13 | Duke University | A method of preventing or treating estrogen-dependent diseases and disorders |
| US6245789B1 (en) | 1998-05-19 | 2001-06-12 | The Procter & Gamble Company | HIV and viral treatment |
| US6423734B1 (en) | 1999-08-13 | 2002-07-23 | The Procter & Gamble Company | Method of preventing cancer |
| US6380232B1 (en) | 2000-09-26 | 2002-04-30 | The Procter & Gamble Company | Benzimidazole urea derivatives, and pharmaceutical compositions and unit dosages thereof |
| US6407105B1 (en) | 2000-09-26 | 2002-06-18 | The Procter & Gamble Company | Compounds and methods for use thereof in the treatment of cancer or viral infections |
| US6608096B1 (en) | 2000-09-26 | 2003-08-19 | University Of Arizona Foundation | Compounds and methods for use thereof in the treatment of cancer or viral infections |
| US6462062B1 (en) * | 2000-09-26 | 2002-10-08 | The Procter & Gamble Company | Compounds and methods for use thereof in the treatment of cancer or viral infections |
| US6515074B2 (en) * | 2001-01-22 | 2003-02-04 | Delphi Technologies, Inc. | Thermoplastic polymer alloy compositions and process for manufacture thereof |
| CA2477764A1 (en) * | 2002-03-26 | 2003-10-09 | Boehringer Ingelheim Pharmaceuticals, Inc. | Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof |
| EP1490062B1 (en) | 2002-03-26 | 2007-12-19 | Boehringer Ingelheim Pharmaceuticals Inc. | Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof |
| US7074806B2 (en) | 2002-06-06 | 2006-07-11 | Boehringer Ingelheim Pharmaceuticals, Inc. | Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof |
| MXPA05006872A (es) | 2003-01-03 | 2005-08-16 | Boehringer Ingelheim Pharma | Derivados de 1-propanol y 1-propilamina y su uso como ligandos glucocorticoides. |
| UY28526A1 (es) | 2003-09-24 | 2005-04-29 | Boehringer Ingelheim Pharma | Miméticos de glucocorticoides, métodos de preparación composiciones farmacéuticas y usos de los mismos |
| US7795272B2 (en) | 2004-03-13 | 2010-09-14 | Boehringer Ingelheim Pharmaceutical, Inc. | Glucocorticoid mimetics, methods of making them, pharmaceutical compositions and uses thereof |
| DE602005015027D1 (de) | 2004-12-27 | 2009-07-30 | Boehringer Ingelheim Pharma | Glucocorticoid-mimetika, verfahren zu deren herstellung, pharmazeutische zusammensetzungen und deren verwendung |
| WO2008070507A2 (en) | 2006-12-06 | 2008-06-12 | Boehringer Ingelheim International Gmbh | Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof |
| EP2095819A1 (en) * | 2008-02-28 | 2009-09-02 | Maastricht University | N-benzyl imidazole derivatives and their use as aldosterone synthase inhibitors |
| PT2300472E (pt) | 2008-06-06 | 2012-02-20 | Boehringer Ingelheim Int | Miméticos de glucocorticóides, métodos de os preparar, composições farmacêuticas e suas utilizações |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2069481B (en) * | 1980-02-13 | 1983-07-27 | Farmos Oy | Substituted imidazole derivatives |
| GB2092569B (en) * | 1981-02-05 | 1984-09-19 | Farmos Oy | Substituted imidazole derivatives and their preparation and use |
| GB2096987B (en) * | 1981-04-22 | 1984-04-04 | Farmos Oy | Substituted imidazole and imidazole derivatives and their preparation and use |
| GB2101114B (en) * | 1981-07-10 | 1985-05-22 | Farmos Group Ltd | Substituted imidazole derivatives and their preparation and use |
| US4605661A (en) * | 1984-06-18 | 1986-08-12 | Eli Lilly And Company | Aromastase inhibiting α,α-diarylimidazole-4(5)-propionitriles, α,α-diarylimidazole-4(5)-propionamides, and 4(5)-(2,2-diarylethyl)imidazoles |
| LU85747A1 (fr) * | 1985-01-28 | 1986-08-04 | Continental Pharma | Derives d'imidazole leur preparation et utilisation ainsi que les compositions pharmaceutiques contenant des derives |
| GB2210875B (en) | 1987-10-09 | 1991-05-29 | Farmos Oy | Aromatase inhibiting 4(5)-imidazoles |
| JPH032168A (ja) | 1989-03-30 | 1991-01-08 | Farmos Yhtymae Oy | アロマターゼ阻害活性を有する新規な４（５）―イミダゾール |
-
1987
- 1987-10-09 GB GB8723715A patent/GB2210875B/en not_active Revoked
-
1988
- 1988-09-22 CA CA000578192A patent/CA1329616C/en not_active Expired - Fee Related
- 1988-09-30 FI FI884497A patent/FI93105C/fi not_active IP Right Cessation
- 1988-10-03 DK DK550988A patent/DK550988A/da not_active Application Discontinuation
- 1988-10-06 DD DD88320542A patent/DD282912A5/de not_active IP Right Cessation
- 1988-10-06 NZ NZ226483A patent/NZ226483A/xx unknown
- 1988-10-06 AU AU23490/88A patent/AU615482B2/en not_active Ceased
- 1988-10-07 DE DE8888309413T patent/DE3874073T2/de not_active Expired - Fee Related
- 1988-10-07 IL IL87969A patent/IL87969A/xx not_active IP Right Cessation
- 1988-10-07 HU HU885213A patent/HU201024B/hu not_active IP Right Cessation
- 1988-10-07 EP EP88309413A patent/EP0311447B1/en not_active Expired - Lifetime
- 1988-10-07 UA UA4356681A patent/UA13218A/uk unknown
- 1988-10-07 PT PT88717A patent/PT88717B/pt not_active IP Right Cessation
- 1988-10-07 NO NO884473A patent/NO172048C/no unknown
- 1988-10-07 ES ES88309413T patent/ES2043839T3/es not_active Expired - Lifetime
- 1988-10-07 IE IE305588A patent/IE61180B1/en not_active IP Right Cessation
- 1988-10-07 RU SU884356681A patent/RU1819263C/ru active
- 1988-10-07 ZA ZA887545A patent/ZA887545B/xx unknown
- 1988-10-08 KR KR1019880013196A patent/KR890006593A/ko not_active Ceased
- 1988-10-08 CN CN88108425A patent/CN1036993C/zh not_active Expired - Fee Related
- 1988-10-08 JP JP63254665A patent/JPH01132568A/ja active Pending
-
1990
- 1990-09-27 US US07/588,873 patent/US5098923A/en not_active Expired - Fee Related
-
1992
- 1992-01-23 RU SU925010700A patent/RU2045519C1/ru active
- 1992-11-26 GR GR920402701T patent/GR3006343T3/el unknown
-
1993
- 1993-08-31 LT LTIP916A patent/LT3658B/lt not_active IP Right Cessation
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