ATE86109T1 - Verwendung von substituierten imidazolen zur herstellung eines analgetikums. - Google Patents

Verwendung von substituierten imidazolen zur herstellung eines analgetikums.

Info

Publication number
ATE86109T1
ATE86109T1 AT90311245T AT90311245T ATE86109T1 AT E86109 T1 ATE86109 T1 AT E86109T1 AT 90311245 T AT90311245 T AT 90311245T AT 90311245 T AT90311245 T AT 90311245T AT E86109 T1 ATE86109 T1 AT E86109T1
Authority
AT
Austria
Prior art keywords
imidazole
analgesic
manufacture
substituted imidazole
dimethylphenyl
Prior art date
Application number
AT90311245T
Other languages
English (en)
Inventor
Eija Kalso
Risto Lammintausta
Original Assignee
Orion Yhtymae Oy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Orion Yhtymae Oy filed Critical Orion Yhtymae Oy
Application granted granted Critical
Publication of ATE86109T1 publication Critical patent/ATE86109T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Neurology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Cephalosporin Compounds (AREA)
  • Dental Preparations (AREA)
  • Stringed Musical Instruments (AREA)
  • Golf Clubs (AREA)
AT90311245T 1989-10-17 1990-10-15 Verwendung von substituierten imidazolen zur herstellung eines analgetikums. ATE86109T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FI894911A FI894911A0 (fi) 1989-10-17 1989-10-17 En terapeutiskt vaerdefull foerening.
EP90311245A EP0424059B1 (de) 1989-10-17 1990-10-15 Verwendung von substituierten Imidazolen zur Herstellung eines Analgetikums

Publications (1)

Publication Number Publication Date
ATE86109T1 true ATE86109T1 (de) 1993-03-15

Family

ID=8529172

Family Applications (1)

Application Number Title Priority Date Filing Date
AT90311245T ATE86109T1 (de) 1989-10-17 1990-10-15 Verwendung von substituierten imidazolen zur herstellung eines analgetikums.

Country Status (13)

Country Link
US (1) US5091402A (de)
EP (1) EP0424059B1 (de)
JP (1) JP2950597B2 (de)
AT (1) ATE86109T1 (de)
AU (1) AU624028B2 (de)
CA (1) CA2027876C (de)
DE (1) DE69001006T2 (de)
DK (1) DK0424059T3 (de)
FI (1) FI894911A0 (de)
HU (1) HU207796B (de)
IE (1) IE64062B1 (de)
NZ (2) NZ245002A (de)
ZA (1) ZA908301B (de)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2256135B (en) * 1991-05-31 1995-01-18 Orion Yhtymae Oy Transdermal administration of 4-substituted imidazoles
US7091181B2 (en) 1994-12-12 2006-08-15 Omeros Corporation Method of inhibition of pain and inflammation during surgery comprising administration of soluble TNF receptors
US5750720A (en) * 1996-03-28 1998-05-12 Ortho Pharmaceutical Corporation 4- (thien-3-yl)methyl!-imidazole analgesics
US5621113A (en) * 1996-03-28 1997-04-15 Ortho Pharmaceutical Corporation 4-[(thien-2-yl)methyl]-imidazole analgesics
AR015744A1 (es) * 1998-04-01 2001-05-16 Orion Corp Uso de dexmedetomidina para sedacion en terapia intensiva
US6716867B1 (en) 1998-04-01 2004-04-06 Orion Corporation Use of dexmedetomidine for ICU sedation
EP1117399B1 (de) * 1998-09-28 2005-02-09 Orion Corporation Verwendung von 3-(1h-imidazol-4-ylmethyl)-indan-5-ol zur herstellung eines medikamentes zur intraspinalen, intrathekalen und epiduralen anwendung
US7973068B2 (en) 1998-10-20 2011-07-05 Omeros Corporation Arthroscopic irrigation solution and method for peripheral vasoconstriction and inhibition of pain and inflammation
US20030087962A1 (en) 1998-10-20 2003-05-08 Omeros Corporation Arthroscopic irrigation solution and method for peripheral vasoconstriction and inhibition of pain and inflammation
ATE291907T1 (de) * 1998-10-20 2005-04-15 Omeros Corp Spülende lösung und methoden zur hemmung von schmerzen und entzündungen
EP1563838A3 (de) * 1998-10-20 2009-11-04 Omeros Corporation Spülende Lösung und Methoden zur Hemmung von Schmerzen und Entzündungen
EP1196168A2 (de) * 1999-06-25 2002-04-17 Orion Corporation Verfahren zur verabreichung eines imidazolderivats um analgesie zu erhalten
JP4741131B2 (ja) 1999-10-29 2011-08-03 オリオン コーポレーション 低血圧およびショックの治療または予防
DE602007004949D1 (de) * 2006-01-27 2010-04-08 Hoffmann La Roche Verwendung von 4-imidazol-derivaten für zns-erkrankungen
KR101176699B1 (ko) 2006-10-19 2012-08-23 에프. 호프만-라 로슈 아게 아미노메틸-4-이미다졸
ATE533755T1 (de) 2006-11-02 2011-12-15 Hoffmann La Roche Substituierte 2-imidazole als modulatoren der mit spurenaminen assoziierten rezeptoren
RU2456281C2 (ru) 2006-11-16 2012-07-20 Ф. Хоффманн-Ля Рош Аг Замещенные 4-имидазолы, способ их получения и их применение
BRPI0720047A2 (pt) 2006-12-13 2013-12-24 Hoffmann La Roche 2-imidazóis como ligantes para receptores associados a aminas de traço (taar)
US20080146523A1 (en) 2006-12-18 2008-06-19 Guido Galley Imidazole derivatives
CA2675221C (en) 2007-02-02 2016-02-23 F. Hoffmann-La Roche Ag Novel 2-aminooxazolines as taar1 ligands
KR101222412B1 (ko) 2007-02-15 2013-01-15 에프. 호프만-라 로슈 아게 Ｔａａｒ1 리간드로서의 2-아미노옥사졸린
WO2009003868A2 (en) 2007-07-02 2009-01-08 F. Hoffmann-La Roche Ag 2 -imidazolines having a good affinity to the trace amine associated receptors (taars)
CA2691704A1 (en) 2007-07-03 2009-01-08 F. Hoffmann-La Roche Ag 4-imidazolines and their use as antidepressants
BRPI0813837A2 (pt) 2007-07-27 2015-01-06 Hoffmann La Roche 2-azetidinametanoaminas e 2-pirrolidinametanoaminas como ligantes de taar
JP5341084B2 (ja) 2007-08-03 2013-11-13 エフ．ホフマン−ラ ロシュ アーゲー Ｔａａｒ１リガンドとしてのピリジンカルボキシアミド及びベンズアミド誘導体
US8242153B2 (en) 2008-07-24 2012-08-14 Hoffmann-La Roche Inc. 4,5-dihydro-oxazol-2YL derivatives
ES2733905T3 (es) * 2009-02-13 2019-12-03 Allergan Inc Composiciones farmacéuticas que comprenden (3-(1-(1H-imidazol-4-il)etil)-2-metilfenil)metanol
PE20120713A1 (es) * 2009-05-15 2012-07-08 Recro Pharma Inc Composiciones sublinguales de dexmedetomidina y metodos para su uso
US8354441B2 (en) 2009-11-11 2013-01-15 Hoffmann-La Roche Inc. Oxazoline derivatives
US9452980B2 (en) 2009-12-22 2016-09-27 Hoffmann-La Roche Inc. Substituted benzamides
RU2012133969A (ru) * 2010-01-08 2014-02-20 Рекро Фарма, Инк. Локальные трансдермальные композиции дексмедетомидина и способы их применения
US20130096170A1 (en) 2011-10-14 2013-04-18 Hospira, Inc. Methods of treating pediatric patients using dexmedetomidine
EP2782569A1 (de) 2011-11-21 2014-10-01 Allergan, Inc. Pharmazeutische zusammensetzungen mit 4-[1-(2,3-dimethylphenyl-)ethyl-]3h-imidazolderivaten zur behandlung von netzhauterkrankungen
SG10201604653TA (en) 2011-12-11 2016-07-28 Recro Pharma Inc Intranasal dexmedetomidine compositions and methods of use thereof
US8242158B1 (en) 2012-01-04 2012-08-14 Hospira, Inc. Dexmedetomidine premix formulation
RU2018105761A (ru) 2013-10-07 2019-02-26 ТЕЙКОКУ ФАРМА ЮЭсЭй, ИНК. Устройства для трансдермальной доставки дексмедетомидина и способы их применения
KR101891185B1 (ko) 2013-10-07 2018-08-24 테이코쿠 팔마 유에스에이, 인코포레이티드 비진정량의 덱스메데토미딘의 경피 전달을 위한 방법 및 조성물
US20150098997A1 (en) 2013-10-07 2015-04-09 Teikoku Pharma Usa, Inc. Methods and Compositions for Treating Attention Deficit Hyperactivity Disorder, Anxiety and Insomnia Using Dexmedetomidine Transdermal Compositions
CN104814966B (zh) * 2015-04-20 2017-12-29 宋兴荣 一种椎管内麻醉剂及其制备方法和应用
AU2017234042B2 (en) 2016-03-17 2020-11-19 F. Hoffmann-La Roche Ag 5-ethyl-4-methyl-pyrazole-3-carboxamide derivative having activity as agonist of TAAR
US9717796B1 (en) 2016-04-20 2017-08-01 Slypharma, Llc Heat sterilizeable, premixed, ready to use dexmedetomidine solution packaged in a flexible plastic container
US11160791B2 (en) 2018-11-01 2021-11-02 Medefil, Inc. Dexmedetomidine injection premix formulation in ready to use (RTU) bags

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2215206B (en) * 1988-02-29 1991-07-03 Farmos Oy 4-substituted imidazole derivatives useful in perioperative care

Also Published As

Publication number Publication date
EP0424059B1 (de) 1993-03-03
HU207796B (en) 1993-06-28
DE69001006T2 (de) 1993-07-08
NZ245002A (en) 1997-07-27
HUT55228A (en) 1991-05-28
DE69001006D1 (de) 1993-04-08
EP0424059A1 (de) 1991-04-24
HU906460D0 (en) 1991-04-29
IE903710A1 (en) 1991-04-24
AU6464290A (en) 1991-04-26
CA2027876A1 (en) 1991-04-18
US5091402A (en) 1992-02-25
DK0424059T3 (da) 1993-04-05
NZ235716A (en) 1997-04-24
JPH03133921A (ja) 1991-06-07
FI894911A0 (fi) 1989-10-17
IE64062B1 (en) 1995-07-12
ZA908301B (en) 1991-09-25
CA2027876C (en) 2002-01-22
AU624028B2 (en) 1992-05-28
JP2950597B2 (ja) 1999-09-20

Similar Documents

Publication Publication Date Title
ATE86109T1 (de) Verwendung von substituierten imidazolen zur herstellung eines analgetikums.
GB2215206B (en) 4-substituted imidazole derivatives useful in perioperative care
DE69329727T2 (de) Neue imidazol derivate, ihre herstellung und therapeutische verwendung
DE68907921D1 (de) Substituierte pyrrol-, pyrazol- und triazol-angiotensin ii-antagonisten.
ES537182A0 (es) Procedimiento de obtencion de compuestos de 1-aril-2-(3-(4-trifluormetilestiril)-1,2,4-triazol-1-il)-1-c 1,2,4,-triazol-1-il-metil) etanol de efecto antifugal.
KR890006593A (ko) 아르마타제 억제4(5)- 이미다졸
DE69529121T2 (de) Verwendung von CRF-Antagonisten
DE69311837D1 (de) Steroide zur Behandlung von Prostatisch-Hypertrophe, ihre Herstellung und Verwendung
CA2371012A1 (en) 4-(1h-pyrrol-1-yl) imidazoles
BR9713542A (pt) Compostos de 2 - imidazolinilaminoindol úteis como agonistas do alfa - 2 - adrenoceptor
DE69225240T2 (de) Substituierte imidazol derivate und deren herstellung und verwendung
KR830004266A (ko) 호모세린 유도체의 제조방법과 살균제로서의 사용
KR950011408A (ko) 사이클릭 아민 유도체
DE58903385D1 (de) Substituierte 3-aminosydnonimine, verfahren zu ihrer herstellung und ihre verwendung.
YU101291A (sh) Postupak za dobijanje triazolil-izopropanola
DE59208898D1 (de) NEUE IN 4-STELLUNG DURCH ARYL ODER N-HETEROARYL SUBSTITUIERTE 2H-BENZO[b]PYRAN-DERIVATE, VERFAHREN ZU IHRER HERSTELLUNG UND IHRE VERWENDUNG SOWIE DIE VERBINDUNGEN ENTHALTENDE ZUBEREITUNGEN
DE60209708D1 (de) Azol- oder triazol-derivate, verfahren zu deren herstellung und ihre verwendung als fungizide
DE60205239D1 (de) Azol- oder triazol-derivate, verfahren zu deren herstellung und ihre verwendung als antifungale arzneimittel
PT86890A (pt) 1-(1-aryl-2-hydroxy-ethyl)-imidazole und deren salze verfahren zu ihrer herstellung diese verbindungen enthaltende arzneimittel und ihre verwendung
AU627010B2 (en) Dichloro-substituted imidazole derivatives as antifungal agents
KR840008801A (ko) 아졸 유도체의 제조방법

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee