DE69225240D1 - Substituierte imidazol derivate und deren herstellung und verwendung - Google Patents

Substituierte imidazol derivate und deren herstellung und verwendung

Info

Publication number
DE69225240D1
DE69225240D1 DE69225240T DE69225240T DE69225240D1 DE 69225240 D1 DE69225240 D1 DE 69225240D1 DE 69225240 T DE69225240 T DE 69225240T DE 69225240 T DE69225240 T DE 69225240T DE 69225240 D1 DE69225240 D1 DE 69225240D1
Authority
DE
Germany
Prior art keywords
compounds
pct
inden
dihydro
imidazole
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69225240T
Other languages
English (en)
Other versions
DE69225240T2 (de
Inventor
Arto Karjalainen
Raimo Virtanen
Arja Karjalainen
Maire Eloranta
Jarmo Salonen
Hannu Sipilae
Antti Haapalinna
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Juvanita Pharma Ltd Oy
Original Assignee
Juvanita Pharma Ltd Oy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Juvanita Pharma Ltd Oy filed Critical Juvanita Pharma Ltd Oy
Publication of DE69225240D1 publication Critical patent/DE69225240D1/de
Application granted granted Critical
Publication of DE69225240T2 publication Critical patent/DE69225240T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Epidemiology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Hospice & Palliative Care (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Psychiatry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epoxy Resins (AREA)
  • Plural Heterocyclic Compounds (AREA)
DE69225240T 1991-12-20 1992-12-18 Substituierte imidazol derivate und deren herstellung und verwendung Expired - Lifetime DE69225240T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB919127050A GB9127050D0 (en) 1991-12-20 1991-12-20 Substituted imidazole derivatives and their preparation and use
PCT/FI1992/000349 WO1993013074A1 (en) 1991-12-20 1992-12-18 Substituted imidazole derivatives and their preparation and use

Publications (2)

Publication Number Publication Date
DE69225240D1 true DE69225240D1 (de) 1998-05-28
DE69225240T2 DE69225240T2 (de) 1998-08-27

Family

ID=10706581

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69225240T Expired - Lifetime DE69225240T2 (de) 1991-12-20 1992-12-18 Substituierte imidazol derivate und deren herstellung und verwendung

Country Status (17)

Country Link
US (1) US5498623A (de)
EP (1) EP0618906B1 (de)
JP (1) JP3276371B2 (de)
AT (1) ATE165350T1 (de)
AU (1) AU664584B2 (de)
CA (1) CA2117305C (de)
DE (1) DE69225240T2 (de)
DK (1) DK0618906T3 (de)
ES (1) ES2115046T3 (de)
FI (1) FI104968B (de)
GB (1) GB9127050D0 (de)
HK (1) HK1008962A1 (de)
HU (1) HU220043B (de)
NO (1) NO304227B1 (de)
PL (1) PL172532B1 (de)
RU (1) RU2120440C1 (de)
WO (1) WO1993013074A1 (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9312669D0 (en) * 1993-06-18 1993-08-04 Orion Yhtymae Oy New opticla isomers
FR2735776B1 (fr) * 1995-06-22 1997-07-18 Synthelabo Derives de 2,3-dihydro-1h-indole, leur preparation et leur application en therapeutique
GB9520150D0 (en) * 1995-10-03 1995-12-06 Orion Yhtymae Oy New imidazole derivatives
US20020143007A1 (en) * 1996-02-02 2002-10-03 Garvey David S. Nitrosated and nitrosylated alpha-adrenergic receptor antagonists, compositions and methods of use
US6469065B1 (en) 1996-02-02 2002-10-22 Nitromed, Inc. Nitrosated and nitrosylated α-adrenergic receptor antagonist, compositions and methods of use
FI20000073A0 (fi) * 2000-01-14 2000-01-14 Orion Yhtymae Oy Uusia imidatsolijohdannaisia
US6388090B2 (en) 2000-01-14 2002-05-14 Orion Corporation Imidazole derivatives
US8188126B2 (en) 2002-05-16 2012-05-29 Pierre Fabre Medicament Imidazolic compounds and use thereof as alpha-2 adrenergic receptors
FI20022007A0 (fi) * 2002-11-08 2002-11-08 Juvantia Pharma Ltd Oy Oromukosaalinen valmiste ja menetelmä sen valmistamiseksi
GB0226076D0 (en) * 2002-11-08 2002-12-18 Rp Scherer Technologies Inc Improved formulations containing substituted imidazole derivatives
EP2456749B1 (de) 2009-07-24 2016-03-30 DSM Pharma Chemicals Regensburg GmbH Indanderivate zur verwendung als zwischenprodukte
WO2011014613A2 (en) * 2009-07-31 2011-02-03 Dr. Reddy's Laboratories Ltd. Preparation of fipamezole
EP2502917A1 (de) 2011-03-17 2012-09-26 Santhera Pharmaceuticals (Schweiz) AG Im Festzustand kristalline Formen von 4-(2-Ethyl-5-fluor-2,3-dihydro-1H-inden-2-yl)-1H-imidazol
EP3370718B1 (de) * 2015-11-05 2021-01-27 University Of Louisville Research Foundation, Inc. Lokale und regionale anästhesie und analgesie
WO2024160908A1 (en) * 2023-02-01 2024-08-08 Univerza V Ljubljani N,n-dialkyl-4-(2-ethylindan-2-yl)-1h-imidazole-1-carboxamides and related compounds for treatment of neurodegenerative diseases
LU103072B1 (en) * 2023-02-15 2024-08-19 Univ Ljubljani N,N-DIALKYL-4-(2-ETHYLINDAN-2-YL)-lH-IMIDAZOLE-l-CARBOXAMIDES AND RELATED COMPOUNDS FOR TREATMENT OF NEURODEGENERATIVE DISEASES

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1282535A (en) * 1970-03-02 1972-07-19 Pfizer (2-IMIDAZOLIN-2-YLAMINO)SUBSTITUTED BENZO[b]THIOPHENES
US3927023A (en) * 1974-05-24 1975-12-16 Warner Lambert Co Imidazolyl benzofurans
US3927018A (en) * 1974-12-23 1975-12-16 Sandoz Ag 3-(2-Methyl-1-imidazolyl)-3-phenyl-1-(3H)isobenzofuranones
IL66242A0 (en) * 1981-07-23 1982-11-30 Erba Farmitalia N-imidazolyl derivatives of 1,2,3,4-tetrahydro-naphthalene,indan and 2-substituted-1-chroman,their preparation and pharmaceutical compositions containing them
NZ201219A (en) * 1981-07-28 1984-10-19 Reckitt & Colmann Prod Ltd Dihydrobenzofuranyl-2-imidazolines and pharmaceutical compositions
ES523609A0 (es) * 1982-07-05 1985-03-01 Erba Farmitalia Procedimiento para preparar derivados n-imidazolilicos de compuestos biciclicos.
GB8409884D0 (en) * 1984-04-17 1984-05-31 Detexomat Machinery Ltd Transporting fabric pieces
GB2167408B (en) * 1984-11-23 1988-05-25 Farmos Oy Substituted imidazole derivatives and their preparation and use
FI81092C (fi) * 1986-05-15 1990-09-10 Farmos Oy Foerfarande foer framstaellning av terapeutiskt aktiva 4(5)-(2,3-dihydro-1h-inden-2-yl)-imidazolderivat.
JP2855341B2 (ja) * 1988-06-10 1999-02-10 武田薬品工業株式会社 新規２―置換クマラン誘導体
IL91542A0 (en) * 1988-10-06 1990-04-29 Erba Carlo Spa N-imidazolyl-and n-imidazolyl-methyl derivatives of substituted bicyclic compounds,their preparation and pharmaceutical compositions containing them
GB2225782A (en) * 1988-12-09 1990-06-13 Farmos Group Limited Imidazole derivatives useful for treatment of diabetes
GB9020128D0 (en) * 1990-09-14 1990-10-24 Reckitt & Colmann Prod Ltd Imidazoline derivatives
AU677171B2 (en) * 1991-12-23 1997-04-17 Mobil Oil Corporation Low oxygen transmissive film
GB9127430D0 (en) * 1991-12-27 1992-02-19 Scras Benzofuranylimidazole derivatives

Also Published As

Publication number Publication date
NO942335L (no) 1994-06-20
FI942882A (fi) 1994-06-16
HU220043B (hu) 2001-10-28
JP3276371B2 (ja) 2002-04-22
ES2115046T3 (es) 1998-06-16
AU3160593A (en) 1993-07-28
FI104968B (fi) 2000-05-15
RU94031215A (ru) 1996-04-20
NO304227B1 (no) 1998-11-16
HK1008962A1 (en) 1999-05-21
NO942335D0 (no) 1994-06-17
ATE165350T1 (de) 1998-05-15
US5498623A (en) 1996-03-12
CA2117305C (en) 2003-11-25
RU2120440C1 (ru) 1998-10-20
DK0618906T3 (da) 1999-01-25
GB9127050D0 (en) 1992-02-19
EP0618906A1 (de) 1994-10-12
AU664584B2 (en) 1995-11-23
CA2117305A1 (en) 1993-07-08
JPH07506087A (ja) 1995-07-06
EP0618906B1 (de) 1998-04-22
WO1993013074A1 (en) 1993-07-08
FI942882A0 (fi) 1994-06-16
HU9401823D0 (en) 1994-09-28
DE69225240T2 (de) 1998-08-27
HUT67548A (en) 1995-04-28
PL172532B1 (en) 1997-10-31

Similar Documents

Publication Publication Date Title
DE69225240D1 (de) Substituierte imidazol derivate und deren herstellung und verwendung
US4438267A (en) Monoheteroring compounds and their use
DE69917296T2 (de) Neue substituierte triazolverbindungen
ES2164657T3 (es) Derivados aza-biciclicos puenteados como antagonistas de la sustancia p.
JP3073047B2 (ja) 毛髪の脱落防止並びに発育促進用組成物
JPH03118372A (ja) ２―アミノピリミジン３―オキシド誘導体、及び２―アミノピリミジン３―オキシドから誘導される新規な化合物を含む、髪の損失を遅らせるためのそして髪の生長を誘発しそして刺激するための使用を意図された組成物
DE69713582D1 (de) Zimtsäurederivate und deren verwendung als integrin-antagonisten
DE60140860D1 (de) 2-aminonicotinamid-derivate und ihre verwendung als vegf-rezeptor tyrosin-kinase inhibitoren
FI942187A0 (fi) Asyklisiä etyleenidiamiinijohdannaisia aine P-reseptoriantagonisteina
KR940021533A (ko) 벤즈이미다졸 화합물, 그들의 용도 및 제조방법
SG65388G (en) Substituted imidazole derivatives and their preparation and use
DK0880517T3 (da) Quinazolin-forbindelser
CA2114542A1 (en) Benzimidazolone derivatives as 5-ht1a and 5-ht2 antagonists
DE69613457D1 (de) 5-(4-subst.-piperidinyl-1)-3-aryl-pentansäure derivate als tachykinin rezeptor antagonisten
US3992378A (en) Fluoralkyl quinoxadinediones
DE69207301T2 (de) Substituierte 3-Piperazinylalkyl 2,3-Dihydro-4H-1,3-Benzoxazin-4-One, deren Herstellung und Verwendung in Heilkunde
NO872004L (no) Fremgangsmaate for fremstilling av terapeutisk aktive 4(5)-substituerte imidazol-derivater.
NZ228722A (en) Substituted indole and indazole derivatives and pharmaceutical compositions
US4945093A (en) Novel derivatives of ureylene, 2,4-triaminopyrimidine-3- oxide, their preparation and use in cosmetic and pharmaceutical compositions
ATE193705T1 (de) 4-p-fluorbenzoyl-1-piperidinyl-propoxy-chromen- - on derivate, deren herstellung und deren verwendung zur behandlung von psychosen und schizophrenie
ATE203022T1 (de) 4-(6-fluor-1,2-benzisoxazolyl)-1-piperidinyl- propoxy-chromen-4-on-derivate,ihre herstellung und ihre verwendung in der behandlung von psychosen, schizophrenie und angstzuständen
UA27738C2 (uk) 2,3,4,5,6,7-гексагідро-1-[4-[1-[4-(2метоксифеніл)піперазиніл]]-2-фенілбутирил]-1н-азепін або його фармацевтично прийнятна кислотно-адитивна сіль, що мають властивість пов'язувати рецептор 5нт1а, спосіб (варіанти) їх одержання, фармацевтична композиція

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
R071 Expiry of right

Ref document number: 618906

Country of ref document: EP