DE69001006D1 - Verwendung von substituierten imidazolen zur herstellung eines analgetikums. - Google Patents

Verwendung von substituierten imidazolen zur herstellung eines analgetikums.

Info

Publication number
DE69001006D1
DE69001006D1 DE9090311245T DE69001006T DE69001006D1 DE 69001006 D1 DE69001006 D1 DE 69001006D1 DE 9090311245 T DE9090311245 T DE 9090311245T DE 69001006 T DE69001006 T DE 69001006T DE 69001006 D1 DE69001006 D1 DE 69001006D1
Authority
DE
Germany
Prior art keywords
imidazole
analgetic
production
substituted imidazoles
dimethylphenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE9090311245T
Other languages
English (en)
Other versions
DE69001006T2 (de
Inventor
Eija Kalso
Risto Lammintausta
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Orion Oyj
Original Assignee
Orion Yhtyma Oy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Orion Yhtyma Oy filed Critical Orion Yhtyma Oy
Application granted granted Critical
Publication of DE69001006D1 publication Critical patent/DE69001006D1/de
Publication of DE69001006T2 publication Critical patent/DE69001006T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)
  • Dental Preparations (AREA)
  • Stringed Musical Instruments (AREA)
  • Golf Clubs (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Cephalosporin Compounds (AREA)
DE9090311245T 1989-10-17 1990-10-15 Verwendung von substituierten imidazolen zur herstellung eines analgetikums. Expired - Fee Related DE69001006T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FI894911A FI894911A0 (fi) 1989-10-17 1989-10-17 En terapeutiskt vaerdefull foerening.

Publications (2)

Publication Number Publication Date
DE69001006D1 true DE69001006D1 (de) 1993-04-08
DE69001006T2 DE69001006T2 (de) 1993-07-08

Family

ID=8529172

Family Applications (1)

Application Number Title Priority Date Filing Date
DE9090311245T Expired - Fee Related DE69001006T2 (de) 1989-10-17 1990-10-15 Verwendung von substituierten imidazolen zur herstellung eines analgetikums.

Country Status (13)

Country Link
US (1) US5091402A (de)
EP (1) EP0424059B1 (de)
JP (1) JP2950597B2 (de)
AT (1) ATE86109T1 (de)
AU (1) AU624028B2 (de)
CA (1) CA2027876C (de)
DE (1) DE69001006T2 (de)
DK (1) DK0424059T3 (de)
FI (1) FI894911A0 (de)
HU (1) HU207796B (de)
IE (1) IE64062B1 (de)
NZ (2) NZ235716A (de)
ZA (1) ZA908301B (de)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
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GB2256135B (en) * 1991-05-31 1995-01-18 Orion Yhtymae Oy Transdermal administration of 4-substituted imidazoles
US7091181B2 (en) 1994-12-12 2006-08-15 Omeros Corporation Method of inhibition of pain and inflammation during surgery comprising administration of soluble TNF receptors
US5750720A (en) * 1996-03-28 1998-05-12 Ortho Pharmaceutical Corporation 4- (thien-3-yl)methyl!-imidazole analgesics
US5621113A (en) * 1996-03-28 1997-04-15 Ortho Pharmaceutical Corporation 4-[(thien-2-yl)methyl]-imidazole analgesics
US6716867B1 (en) 1998-04-01 2004-04-06 Orion Corporation Use of dexmedetomidine for ICU sedation
AR015744A1 (es) * 1998-04-01 2001-05-16 Orion Corp Uso de dexmedetomidina para sedacion en terapia intensiva
KR100646811B1 (ko) * 1998-09-28 2006-11-17 오리온 코포레이션 척추내, 척수강내, 또는 경막외 투여용 약물 제조에서3-(1에이치-이미다졸-4-일메틸)-인단-5-올의 용도
ATE291907T1 (de) * 1998-10-20 2005-04-15 Omeros Corp Spülende lösung und methoden zur hemmung von schmerzen und entzündungen
EP1563838A3 (de) * 1998-10-20 2009-11-04 Omeros Corporation Spülende Lösung und Methoden zur Hemmung von Schmerzen und Entzündungen
US7973068B2 (en) 1998-10-20 2011-07-05 Omeros Corporation Arthroscopic irrigation solution and method for peripheral vasoconstriction and inhibition of pain and inflammation
US20030087962A1 (en) 1998-10-20 2003-05-08 Omeros Corporation Arthroscopic irrigation solution and method for peripheral vasoconstriction and inhibition of pain and inflammation
AU5537800A (en) * 1999-06-25 2001-01-31 Orion Corporation Method of admistering an imidazole derivative to obtain analgesia
WO2001030347A1 (en) 1999-10-29 2001-05-03 Orion Corporation Treatment or prevention of hypotension and shock
EP1981880B1 (de) * 2006-01-27 2010-02-24 F.Hoffmann-La Roche Ag Verwendung von 4-imidazol-derivaten für zns-erkrankungen
ATE546437T1 (de) 2006-10-19 2012-03-15 Hoffmann La Roche Aminomethyl-4-imidazole
KR101176700B1 (ko) 2006-11-02 2012-08-23 에프. 호프만-라 로슈 아게 미량 아민 결합된 수용체의 조절자로서 치환된 2-이미다졸
CA2669112A1 (en) * 2006-11-16 2008-05-22 F. Hoffmann-La Roche Ag Substituted 4-imidazoles
JP2010513238A (ja) 2006-12-13 2010-04-30 エフ．ホフマン−ラ ロシュ アーゲー 微量アミン関連受容体（ｔａａｒ）に対するリガンドとしての新規２−イミダゾール
US20080146523A1 (en) 2006-12-18 2008-06-19 Guido Galley Imidazole derivatives
KR101275405B1 (ko) 2007-02-02 2013-06-17 에프. 호프만-라 로슈 아게 중추 신경계 장애의 치료용 ｔａａｒ1 리간드로서 2-아미노옥사졸린
KR101335845B1 (ko) 2007-02-15 2013-12-02 에프. 호프만-라 로슈 아게 Ｔａａｒ1 리간드로서의 2-아미노옥사졸린
WO2009003868A2 (en) 2007-07-02 2009-01-08 F. Hoffmann-La Roche Ag 2 -imidazolines having a good affinity to the trace amine associated receptors (taars)
AU2008270444A1 (en) 2007-07-03 2009-01-08 F. Hoffmann-La Roche Ag 4-imidazolines and their use as antidepressants
EP2183216A1 (de) 2007-07-27 2010-05-12 F. Hoffmann-Roche AG 2-azetidinmethynamine und 2-pyrrolidinmethanamine als taar-liganden
CA2695331A1 (en) 2007-08-03 2009-02-12 F. Hoffmann-La Roche Ag Pyridinecarboxamide and benzamide derivatives as taar1 ligands
US8242153B2 (en) 2008-07-24 2012-08-14 Hoffmann-La Roche Inc. 4,5-dihydro-oxazol-2YL derivatives
DK3566703T3 (da) 2009-02-13 2021-07-05 Allergan Inc Farmaceutiske sammensætninger omfattende (3-(1-(1h-imidazol-4-yl)ethyl)-2-methylphenyl)methanol
KR101859486B1 (ko) * 2009-05-15 2018-06-28 레크로파마, 인코포레이티드 설하용 덱스메데토미딘 조성물과 그의 사용 방법
US8354441B2 (en) 2009-11-11 2013-01-15 Hoffmann-La Roche Inc. Oxazoline derivatives
US9452980B2 (en) 2009-12-22 2016-09-27 Hoffmann-La Roche Inc. Substituted benzamides
AU2011204315A1 (en) * 2010-01-08 2012-08-02 Recro Pharma, Inc. Topical transdermal dexmedetomidine compositions and methods of use thereof
US20130096170A1 (en) 2011-10-14 2013-04-18 Hospira, Inc. Methods of treating pediatric patients using dexmedetomidine
US9095576B2 (en) 2011-11-21 2015-08-04 Allergan, Inc. Pharmaceutical compositions comprising 4-[1-(2,3-dimethylphenyl)ethyl]-3H-imidazole derivatives for treating retinal diseases
EP2787970B1 (de) 2011-12-11 2018-04-11 Recro Pharma, Inc. Intranasale dexmedetomidinzusammensetzungen und verfahren zur verwendung davon
US8242158B1 (en) 2012-01-04 2012-08-14 Hospira, Inc. Dexmedetomidine premix formulation
RU2648449C2 (ru) 2013-10-07 2018-03-26 ТЕЙКОКУ ФАРМА ЮЭсЭй, ИНК. Способы и композиции для трансдермальной доставки неседативного количества дексмедетомидина
EP3054935B1 (de) 2013-10-07 2020-12-09 Teikoku Pharma USA, Inc. Verfahren und zusammensetzungen zur behandlung von hyperaktivität mit aufmerksamkeitsstörungen, angstzuständen und schlaflosigkeit mit transdermalen descmedetomidin-zusammensetzungen
KR101827980B1 (ko) 2013-10-07 2018-02-13 테이코쿠 팔마 유에스에이, 인코포레이티드 덱스메데토미딘 경피 전달 장치 및 이의 사용 방법
CN104814966B (zh) * 2015-04-20 2017-12-29 宋兴荣 一种椎管内麻醉剂及其制备方法和应用
HUE050986T2 (hu) 2016-03-17 2021-01-28 Hoffmann La Roche 5-etil-4-metil-pirazol-3-karboxamid származék, amely TAAR-agonista aktivitású
US9717796B1 (en) 2016-04-20 2017-08-01 Slypharma, Llc Heat sterilizeable, premixed, ready to use dexmedetomidine solution packaged in a flexible plastic container
US11160791B2 (en) 2018-11-01 2021-11-02 Medefil, Inc. Dexmedetomidine injection premix formulation in ready to use (RTU) bags

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2215206B (en) * 1988-02-29 1991-07-03 Farmos Oy 4-substituted imidazole derivatives useful in perioperative care

Also Published As

Publication number Publication date
AU624028B2 (en) 1992-05-28
DE69001006T2 (de) 1993-07-08
AU6464290A (en) 1991-04-26
JPH03133921A (ja) 1991-06-07
IE64062B1 (en) 1995-07-12
IE903710A1 (en) 1991-04-24
DK0424059T3 (da) 1993-04-05
ZA908301B (en) 1991-09-25
NZ245002A (en) 1997-07-27
CA2027876A1 (en) 1991-04-18
FI894911A0 (fi) 1989-10-17
HUT55228A (en) 1991-05-28
EP0424059A1 (de) 1991-04-24
EP0424059B1 (de) 1993-03-03
CA2027876C (en) 2002-01-22
HU906460D0 (en) 1991-04-29
NZ235716A (en) 1997-04-24
HU207796B (en) 1993-06-28
JP2950597B2 (ja) 1999-09-20
ATE86109T1 (de) 1993-03-15
US5091402A (en) 1992-02-25

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee
8327 Change in the person/name/address of the patent owner

Owner name: ORION CORP., ESPOO, FI