KR100646811B1 - 척추내, 척수강내, 또는 경막외 투여용 약물 제조에서3-(1에이치-이미다졸-4-일메틸)-인단-5-올의 용도 - Google Patents
척추내, 척수강내, 또는 경막외 투여용 약물 제조에서3-(1에이치-이미다졸-4-일메틸)-인단-5-올의 용도 Download PDFInfo
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- A—HUMAN NECESSITIES
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- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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- A61P25/00—Drugs for disorders of the nervous system
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Abstract
Description
화합물 | logD(pH1) | logD(pH7.4) |
A | -0.69 | 1.91 |
B | -1.02 | 0.73 |
목록 | 화합물A | 화합물B | |
A | 진통효과1) | 0.7 | 6.4 |
B | 진정작용2) | 30 | 5 |
C | 운동조절의 상실3) | >30 | >10 |
D | 저체온증4) | 10 | 4 |
E | 위장운동의 억제5) | 5.7 | 3.5 |
비율 | B/A | 42.9 | 0.8 |
C/A | >42.9 | >1.6 | |
D/A | 14.3 | 0.6 | |
E/A | 8.1 | 0.5 |
목록 | 정맥 | 피하 | 척추 | |
A | 진통효과 | >30 | >300 | 2.1* |
B | 진정작용 | 80 | 90* |
Claims (36)
- 3-(1H-이미다졸-4-일메틸)-인단-5-올, 그 에난티오머 또는 약학적으로 허용되는 염을 활성성분으로 함유하는 척추투여용 진통 또는 마취보조용 약학적 조성물.
- 제 1항에 있어서, 약물이 3-(1H-이미다졸-4-일메틸)-인단-5-올 염산염인 약학적 조성물.
- 제 1항에 있어서, 척추초내 투여용(intrathecal administration) 약학적 조성물.
- 제 1항에 있어서, 경막외 투여용(epidural administration) 약학적 조성물.
- 청구항 1 또는 2에 있어서, 환자당 30 내지 500μg의 용량단위를 환자에 투여할 수 있는 약학적 조성물.
- 제 5항에 있어서, 환자당 50 내지 200μg의 용량단위인 약학적 조성물.
- 제 1 또는 2항에 있어서, 소형 포유동물용 1 내지 100μg의 용량단위인 약학적 조성물.
- 제 7항에 있어서, 개 또는 고양이용 3 내지 30μg의 용량단위인 약학적 조성물.
- 제 1항 또는 2항에 있어서, 수술중 통증의 치료용 조성물.
- 제 1항 또는 2항에 있어서, 수술 후 통증의 치료용 조성물.
- 제 1항 또는 2항에 있어서, 분만 통증의 치료용 조성물.
- 제 1항 또는 2항에 있어서, 만성 통증의 치료용 조성물.
- 제 1항 또는 2항에 있어서, 경직성 마비 치료용 조성물.
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Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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US10198698P | 1998-09-28 | 1998-09-28 | |
US60101986 | 1998-09-28 |
Publications (2)
Publication Number | Publication Date |
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KR20010079860A KR20010079860A (ko) | 2001-08-22 |
KR100646811B1 true KR100646811B1 (ko) | 2006-11-17 |
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KR1020017003511A KR100646811B1 (ko) | 1998-09-28 | 1999-09-27 | 척추내, 척수강내, 또는 경막외 투여용 약물 제조에서3-(1에이치-이미다졸-4-일메틸)-인단-5-올의 용도 |
Country Status (24)
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US (1) | US6495584B1 (ko) |
EP (1) | EP1117399B1 (ko) |
JP (1) | JP4647785B2 (ko) |
KR (1) | KR100646811B1 (ko) |
CN (1) | CN1320034A (ko) |
AT (1) | ATE288753T1 (ko) |
AU (1) | AU756104B2 (ko) |
BG (1) | BG105469A (ko) |
CA (1) | CA2345521C (ko) |
CZ (1) | CZ299918B6 (ko) |
DE (1) | DE69923698T2 (ko) |
DK (1) | DK1117399T3 (ko) |
EA (1) | EA003216B1 (ko) |
EE (1) | EE200100193A (ko) |
ES (1) | ES2237205T3 (ko) |
HK (1) | HK1039751A1 (ko) |
HU (1) | HU227634B1 (ko) |
IL (2) | IL141680A0 (ko) |
NO (1) | NO330436B1 (ko) |
NZ (1) | NZ510233A (ko) |
PL (1) | PL346908A1 (ko) |
SK (1) | SK3812001A3 (ko) |
UA (1) | UA61152C2 (ko) |
WO (1) | WO2000018400A1 (ko) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
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EP1196168A2 (en) * | 1999-06-25 | 2002-04-17 | Orion Corporation | Method of admistering an imidazole derivative to obtain analgesia |
FI20022159A0 (fi) | 2002-12-05 | 2002-12-05 | Orion Corp | Uusia farmaseuttisia yhdisteitä |
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FI894911A0 (fi) * | 1989-10-17 | 1989-10-17 | Farmos Oy | En terapeutiskt vaerdefull foerening. |
GB9520150D0 (en) | 1995-10-03 | 1995-12-06 | Orion Yhtymae Oy | New imidazole derivatives |
US5801188A (en) * | 1997-01-08 | 1998-09-01 | Medtronic Inc. | Clonidine therapy enhancement |
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1999
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- 1999-09-27 PL PL99346908A patent/PL346908A1/xx not_active Application Discontinuation
- 1999-09-27 EA EA200100405A patent/EA003216B1/ru not_active IP Right Cessation
- 1999-09-27 NZ NZ510233A patent/NZ510233A/en not_active IP Right Cessation
- 1999-09-27 US US09/787,886 patent/US6495584B1/en not_active Expired - Lifetime
- 1999-09-27 SK SK381-2001A patent/SK3812001A3/sk unknown
- 1999-09-27 DK DK99969677T patent/DK1117399T3/da active
- 1999-09-27 IL IL14168099A patent/IL141680A0/xx active IP Right Grant
- 1999-09-27 DE DE69923698T patent/DE69923698T2/de not_active Expired - Lifetime
- 1999-09-27 CN CN99811480A patent/CN1320034A/zh active Pending
- 1999-09-27 EE EEP200100193A patent/EE200100193A/xx unknown
- 1999-09-27 HU HU0103864A patent/HU227634B1/hu unknown
- 1999-09-27 AT AT99969677T patent/ATE288753T1/de not_active IP Right Cessation
- 1999-09-27 EP EP99969677A patent/EP1117399B1/en not_active Expired - Lifetime
- 1999-09-27 JP JP2000571918A patent/JP4647785B2/ja not_active Expired - Lifetime
- 1999-09-27 CZ CZ20010933A patent/CZ299918B6/cs not_active IP Right Cessation
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- 1999-09-27 CA CA002345521A patent/CA2345521C/en not_active Expired - Lifetime
- 1999-09-27 UA UA2001042926A patent/UA61152C2/uk unknown
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2001
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