PE87998A1 - DERIVADOS DE BENZO [g] QUINOLINA - Google Patents

DERIVADOS DE BENZO [g] QUINOLINA

Info

Publication number
PE87998A1
PE87998A1 PE1997000585A PE00058597A PE87998A1 PE 87998 A1 PE87998 A1 PE 87998A1 PE 1997000585 A PE1997000585 A PE 1997000585A PE 00058597 A PE00058597 A PE 00058597A PE 87998 A1 PE87998 A1 PE 87998A1
Authority
PE
Peru
Prior art keywords
quinoline
benzo derivatives
alkyl
compounds
group
Prior art date
Application number
PE1997000585A
Other languages
English (en)
Inventor
Peter Gull
Max Peter Seiler
Rudolf Markstein
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9614282.3A external-priority patent/GB9614282D0/en
Priority claimed from GBGB9626093.0A external-priority patent/GB9626093D0/en
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of PE87998A1 publication Critical patent/PE87998A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/10—Ophthalmic agents for accommodation disorders, e.g. myopia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Ophthalmology & Optometry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

SE REFIEREN A COMPUESTOS DE FORMULA (I), EN DONDE: "A" Y "B" SON H O FORMAN JUNTOS UN ENLACE ADICIONAL; "X" ES CH2 o CO; "Y" ES O, S, NR1, CH2 o O-CH2, EN DONDE R1 ES H o ALQUILO C1-C6, DE PREFERENCIA ES CH3; R ES PIRIDIL, IMIDAZOL O 1,2,4 TRIAZOL, ENTRE OTROS. TAMBIEN SE REFIERE AL PROCEDIMIENTO DE PREPARACION DE (I), QUE COMPRENDE CONVERTIR EL GRUPO ALCOXI DE (II), EN DONDE R2 ES ALQUILO C1-C4, EN UN GRUPO HIDROXI. LOS COMPUESTOS OBTENIDOS SON UTILES EN EL TRATAMIENTO DEL GLAUCOMA
PE1997000585A 1996-07-08 1997-07-07 DERIVADOS DE BENZO [g] QUINOLINA PE87998A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9614282.3A GB9614282D0 (en) 1996-07-08 1996-07-08 Organic compounds
GBGB9626093.0A GB9626093D0 (en) 1996-12-16 1996-12-16 Organic compounds

Publications (1)

Publication Number Publication Date
PE87998A1 true PE87998A1 (es) 1998-12-30

Family

ID=26309658

Family Applications (1)

Application Number Title Priority Date Filing Date
PE1997000585A PE87998A1 (es) 1996-07-08 1997-07-07 DERIVADOS DE BENZO [g] QUINOLINA

Country Status (28)

Country Link
US (1) US6057334A (es)
EP (1) EP0912553B1 (es)
JP (1) JP4216337B2 (es)
KR (1) KR100491478B1 (es)
CN (1) CN1125065C (es)
AR (1) AR007814A1 (es)
AT (1) ATE211470T1 (es)
AU (1) AU719119B2 (es)
BR (1) BR9710218A (es)
CA (1) CA2257646C (es)
CO (1) CO4870760A1 (es)
CY (1) CY2322B1 (es)
CZ (1) CZ2799A3 (es)
DE (1) DE69709869T2 (es)
DK (1) DK0912553T3 (es)
ES (1) ES2170402T3 (es)
HK (1) HK1020569A1 (es)
ID (1) ID18896A (es)
IL (1) IL127376A (es)
NO (1) NO319401B1 (es)
NZ (1) NZ333311A (es)
PE (1) PE87998A1 (es)
PL (1) PL330723A1 (es)
PT (1) PT912553E (es)
SK (1) SK399A3 (es)
TR (1) TR199900016T2 (es)
TW (1) TW378209B (es)
WO (1) WO1998001444A1 (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PE20030240A1 (es) * 2001-07-09 2003-04-16 Novartis Ag DERIVADOS DE BENZO [g] QUINOLINA
DE60328732D1 (de) * 2002-03-07 2009-09-17 Novartis Ag Chinolinderivate und ihre Anwendung bei Glaukom und Kurzsichtigkeit
EG24415A (en) 2002-03-07 2009-05-25 Novartis Ag Quinoline derivatives
US20070093507A1 (en) * 2003-09-05 2007-04-26 Lambrou George N Compositions comprising benzo (g) quinoline derivatives and prostaglandin derivatives
CN105434439B (zh) * 2015-11-11 2018-07-24 温州医科大学 一种多巴胺d2受体的部分激动剂在制备抑制近视药物上的应用及其使用方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0077754B1 (en) * 1981-10-16 1990-09-26 Sandoz Ag Novel pharmaceutically active 1,2,3,4,4a,5,10,10a-octahydrobenzo(g)quinoline derivatives
AU3879789A (en) * 1988-07-22 1990-02-19 Sandoz Ag Use of benzo(g)quinolines in treatment of nicotine addiction
GB8829330D0 (en) * 1988-12-16 1989-02-01 Sandoz Ltd Improvements in or relating to organic compounds
DE4114325A1 (de) * 1991-05-02 1992-11-05 Sandoz Ag Octahydrobenzo(g)chinolin, seine herstellung und verwendung
US5262422A (en) * 1991-05-02 1993-11-16 Sandoz Ltd. Octahydrobenzo[g]quinoline
GB9326010D0 (en) * 1993-12-21 1994-02-23 Sandoz Ltd Improvements in or relating to organic compounds
FR2729145A1 (fr) * 1995-01-06 1996-07-12 Smithkline Beecham Lab Nouveaux derives d'amine, leur procede de preparation et leur utilisation en tant que medicaments et notamment en tant qu'agents anti-arythmiques

Also Published As

Publication number Publication date
ATE211470T1 (de) 2002-01-15
IL127376A0 (en) 1999-10-28
TR199900016T2 (xx) 1999-04-21
NO319401B1 (no) 2005-08-08
CN1225093A (zh) 1999-08-04
DK0912553T3 (da) 2002-04-22
CY2322B1 (en) 2003-11-14
DE69709869D1 (de) 2002-02-28
JP2000514075A (ja) 2000-10-24
NO990035D0 (no) 1999-01-05
KR100491478B1 (ko) 2005-05-27
CN1125065C (zh) 2003-10-22
US6057334A (en) 2000-05-02
TW378209B (en) 2000-01-01
PL330723A1 (en) 1999-05-24
PT912553E (pt) 2002-06-28
HK1020569A1 (en) 2000-05-12
WO1998001444A1 (en) 1998-01-15
EP0912553A1 (en) 1999-05-06
KR20000023572A (ko) 2000-04-25
ID18896A (id) 1998-05-20
ES2170402T3 (es) 2002-08-01
CA2257646C (en) 2006-05-09
CA2257646A1 (en) 1998-01-15
AU3542297A (en) 1998-02-02
CO4870760A1 (es) 1999-12-27
IL127376A (en) 2003-12-10
AR007814A1 (es) 1999-11-24
BR9710218A (pt) 1999-08-10
NO990035L (no) 1999-01-05
DE69709869T2 (de) 2002-08-14
EP0912553B1 (en) 2002-01-02
JP4216337B2 (ja) 2009-01-28
SK399A3 (en) 1999-06-11
NZ333311A (en) 2000-06-23
CZ2799A3 (cs) 1999-03-17
AU719119B2 (en) 2000-05-04

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