DK0424059T3 - Anvendelse af substituerede imidazoler - Google Patents

Anvendelse af substituerede imidazoler

Info

Publication number
DK0424059T3
DK0424059T3 DK90311245.6T DK90311245T DK0424059T3 DK 0424059 T3 DK0424059 T3 DK 0424059T3 DK 90311245 T DK90311245 T DK 90311245T DK 0424059 T3 DK0424059 T3 DK 0424059T3
Authority
DK
Denmark
Prior art keywords
imidazole
dimethylphenyl
ethyl
substituted imidazoles
compounds
Prior art date
Application number
DK90311245.6T
Other languages
Danish (da)
English (en)
Inventor
Risto Lammintausta
Eija Kalso
Original Assignee
Orion Yhtymae Oy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Orion Yhtymae Oy filed Critical Orion Yhtymae Oy
Application granted granted Critical
Publication of DK0424059T3 publication Critical patent/DK0424059T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)
  • Dental Preparations (AREA)
  • Stringed Musical Instruments (AREA)
  • Golf Clubs (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Cephalosporin Compounds (AREA)
DK90311245.6T 1989-10-17 1990-10-15 Anvendelse af substituerede imidazoler DK0424059T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FI894911A FI894911A0 (fi) 1989-10-17 1989-10-17 En terapeutiskt vaerdefull foerening.

Publications (1)

Publication Number Publication Date
DK0424059T3 true DK0424059T3 (da) 1993-04-05

Family

ID=8529172

Family Applications (1)

Application Number Title Priority Date Filing Date
DK90311245.6T DK0424059T3 (da) 1989-10-17 1990-10-15 Anvendelse af substituerede imidazoler

Country Status (13)

Country Link
US (1) US5091402A (de)
EP (1) EP0424059B1 (de)
JP (1) JP2950597B2 (de)
AT (1) ATE86109T1 (de)
AU (1) AU624028B2 (de)
CA (1) CA2027876C (de)
DE (1) DE69001006T2 (de)
DK (1) DK0424059T3 (de)
FI (1) FI894911A0 (de)
HU (1) HU207796B (de)
IE (1) IE64062B1 (de)
NZ (2) NZ245002A (de)
ZA (1) ZA908301B (de)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2256135B (en) * 1991-05-31 1995-01-18 Orion Yhtymae Oy Transdermal administration of 4-substituted imidazoles
US7091181B2 (en) 1994-12-12 2006-08-15 Omeros Corporation Method of inhibition of pain and inflammation during surgery comprising administration of soluble TNF receptors
US5750720A (en) * 1996-03-28 1998-05-12 Ortho Pharmaceutical Corporation 4- (thien-3-yl)methyl!-imidazole analgesics
US5621113A (en) * 1996-03-28 1997-04-15 Ortho Pharmaceutical Corporation 4-[(thien-2-yl)methyl]-imidazole analgesics
AR015744A1 (es) * 1998-04-01 2001-05-16 Orion Corp Uso de dexmedetomidina para sedacion en terapia intensiva
US6716867B1 (en) 1998-04-01 2004-04-06 Orion Corporation Use of dexmedetomidine for ICU sedation
EA003216B1 (ru) * 1998-09-28 2003-02-27 Орион Корпорейшн Применение 3-(1h-имидазол-4-илметил)индан-5-ола при изготовлении лекарственного средства для интраспинального, подоболочечного или эпидурального введения
EP1563838A3 (de) * 1998-10-20 2009-11-04 Omeros Corporation Spülende Lösung und Methoden zur Hemmung von Schmerzen und Entzündungen
ES2239466T3 (es) * 1998-10-20 2005-09-16 Omeros Corporation Solucion de irrigacion y metodo de inhibicion del dolor y de la inflamacion.
US20030087962A1 (en) 1998-10-20 2003-05-08 Omeros Corporation Arthroscopic irrigation solution and method for peripheral vasoconstriction and inhibition of pain and inflammation
US7973068B2 (en) 1998-10-20 2011-07-05 Omeros Corporation Arthroscopic irrigation solution and method for peripheral vasoconstriction and inhibition of pain and inflammation
WO2001000192A2 (en) * 1999-06-25 2001-01-04 Orion Corporation Method of administering an imidazole derivative to obtain analgesia
ATE312606T1 (de) 1999-10-29 2005-12-15 Orion Corp Verwendung eines imidazolderivats zur behandlung oder verhütung von hypotension und schock
EP1981880B1 (de) * 2006-01-27 2010-02-24 F.Hoffmann-La Roche Ag Verwendung von 4-imidazol-derivaten für zns-erkrankungen
AU2007312390B2 (en) 2006-10-19 2013-03-28 F. Hoffmann-La Roche Ag Aminomethyl-4-imidazoles
JP5064511B2 (ja) 2006-11-02 2012-10-31 エフ．ホフマン−ラ ロシュ アーゲー 痕跡アミン関連受容体調節剤としての置換２−イミダゾール
RU2456281C2 (ru) * 2006-11-16 2012-07-20 Ф. Хоффманн-Ля Рош Аг Замещенные 4-имидазолы, способ их получения и их применение
ATE509628T1 (de) 2006-12-13 2011-06-15 Hoffmann La Roche Neue 2-imidazole als liganden für trace amine associated receptors (taar)
US20080146523A1 (en) 2006-12-18 2008-06-19 Guido Galley Imidazole derivatives
BRPI0806940A2 (pt) 2007-02-02 2014-05-06 Hoffmann La Roche 2-amino-oxazolinas como ligantes taar1 para distúrbios do snc
MX2009008465A (es) 2007-02-15 2009-08-20 Hoffmann La Roche Nuevas 2-aminooxazolinas como ligandos de taar1.
AU2008270445A1 (en) 2007-07-02 2009-01-08 F. Hoffmann-La Roche Ag 2 -imidazolines having a good affinity to the trace amine associated receptors (TAARs)
MX2009013745A (es) 2007-07-03 2010-01-26 Hoffmann La Roche 4-imidazolinas y su uso como antidepresivos.
CN101765587A (zh) 2007-07-27 2010-06-30 弗·哈夫曼-拉罗切有限公司 作为taar配体的2-氮杂环丁烷甲胺类和2-吡咯烷甲胺类
CA2695331A1 (en) 2007-08-03 2009-02-12 F. Hoffmann-La Roche Ag Pyridinecarboxamide and benzamide derivatives as taar1 ligands
US8242153B2 (en) 2008-07-24 2012-08-14 Hoffmann-La Roche Inc. 4,5-dihydro-oxazol-2YL derivatives
EP2395999B1 (de) 2009-02-13 2017-09-13 Allergan, Inc. Pharmazeutische zusammensetzungen mit (3-(1-(1h-imidazol-4-yl)ethyl)-2-methylphenyl)methanol
EP2429521B1 (de) * 2009-05-15 2017-10-18 Recro Pharma, Inc. Sublinguale dexmedetomidinzusammensetzungen und verfahren zu ihrer verwendung
US8354441B2 (en) 2009-11-11 2013-01-15 Hoffmann-La Roche Inc. Oxazoline derivatives
US9452980B2 (en) 2009-12-22 2016-09-27 Hoffmann-La Roche Inc. Substituted benzamides
AU2011204315A1 (en) * 2010-01-08 2012-08-02 Recro Pharma, Inc. Topical transdermal dexmedetomidine compositions and methods of use thereof
US20130096170A1 (en) 2011-10-14 2013-04-18 Hospira, Inc. Methods of treating pediatric patients using dexmedetomidine
US9095576B2 (en) 2011-11-21 2015-08-04 Allergan, Inc. Pharmaceutical compositions comprising 4-[1-(2,3-dimethylphenyl)ethyl]-3H-imidazole derivatives for treating retinal diseases
US9795559B2 (en) 2011-12-11 2017-10-24 Recro Pharma, Inc. Intranasal dexmedetomidine compositions and methods of use thereof
US8242158B1 (en) 2012-01-04 2012-08-14 Hospira, Inc. Dexmedetomidine premix formulation
TWI629066B (zh) 2013-10-07 2018-07-11 帝國製藥美國股份有限公司 使用右美托咪啶經皮組成物用於治療注意力不足過動症、焦慮及失眠的方法及組成物
RU2018105761A (ru) 2013-10-07 2019-02-26 ТЕЙКОКУ ФАРМА ЮЭсЭй, ИНК. Устройства для трансдермальной доставки дексмедетомидина и способы их применения
RU2648449C2 (ru) 2013-10-07 2018-03-26 ТЕЙКОКУ ФАРМА ЮЭсЭй, ИНК. Способы и композиции для трансдермальной доставки неседативного количества дексмедетомидина
CN104814966B (zh) * 2015-04-20 2017-12-29 宋兴荣 一种椎管内麻醉剂及其制备方法和应用
BR112018015389B1 (pt) 2016-03-17 2023-12-19 F. Hoffmann-La Roche Ag Derivado de 5-etil-4-metil-pirazol-3-carboxamida, seu processo de fabricação, preparação farmacêutica oral e uso
US9717796B1 (en) 2016-04-20 2017-08-01 Slypharma, Llc Heat sterilizeable, premixed, ready to use dexmedetomidine solution packaged in a flexible plastic container
US11160791B2 (en) 2018-11-01 2021-11-02 Medefil, Inc. Dexmedetomidine injection premix formulation in ready to use (RTU) bags

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2215206B (en) * 1988-02-29 1991-07-03 Farmos Oy 4-substituted imidazole derivatives useful in perioperative care

Also Published As

Publication number Publication date
HU207796B (en) 1993-06-28
ZA908301B (en) 1991-09-25
AU624028B2 (en) 1992-05-28
DE69001006T2 (de) 1993-07-08
EP0424059B1 (de) 1993-03-03
DE69001006D1 (de) 1993-04-08
HUT55228A (en) 1991-05-28
NZ235716A (en) 1997-04-24
JP2950597B2 (ja) 1999-09-20
FI894911A0 (fi) 1989-10-17
IE64062B1 (en) 1995-07-12
EP0424059A1 (de) 1991-04-24
HU906460D0 (en) 1991-04-29
NZ245002A (en) 1997-07-27
US5091402A (en) 1992-02-25
CA2027876C (en) 2002-01-22
ATE86109T1 (de) 1993-03-15
AU6464290A (en) 1991-04-26
CA2027876A1 (en) 1991-04-18
IE903710A1 (en) 1991-04-24
JPH03133921A (ja) 1991-06-07

Similar Documents

Publication Publication Date Title
DK0424059T3 (da) Anvendelse af substituerede imidazoler
DE69007740D1 (de) Substituierte 5-[(Tetrazolyl)alkenyl]-Imidazole.
IL142649A0 (en) Azole derivatives
DE68907921D1 (de) Substituierte pyrrol-, pyrazol- und triazol-angiotensin ii-antagonisten.
ATE17121T1 (de) Substituierte imidazolderivate und deren herstellung und anwendung.
ATE197951T1 (de) Neue imidazol derivate, ihre herstellung und therapeutische verwendung
GB2215206B (en) 4-substituted imidazole derivatives useful in perioperative care
IE850187L (en) Imidazoles
ES537182A0 (es) Procedimiento de obtencion de compuestos de 1-aril-2-(3-(4-trifluormetilestiril)-1,2,4-triazol-1-il)-1-c 1,2,4,-triazol-1-il-metil) etanol de efecto antifugal.
CA2371012A1 (en) 4-(1h-pyrrol-1-yl) imidazoles
BR9713542A (pt) Compostos de 2 - imidazolinilaminoindol úteis como agonistas do alfa - 2 - adrenoceptor
AU641952B2 (en) Substituted N-(imidazolyl)alkyl alanine derivatives
ES2127789T3 (es) Derivados de 1,2,4-triazol 4-sustituidos.
ATE165350T1 (de) Substituierte imidazol derivate und deren herstellung und verwendung
ES2091489T3 (es) Derivados de imidazol y composiciones farmaceuticas que los contienen.
ATE179979T1 (de) Triazolopyrimidinderivate als angiotensin-ii rezeptor antagonisten
DE60144246D1 (de) Imidazolderivate, verfahren zu deren herstellung und deren verwendung
FI962322A0 (fi) (S,S,S)-N-(1-(2-karboksi-3-(N2-mesyylilysyyliamino)propyyli)1-syklopentyylikarbonyylityrosiinin kiteinen polymorfinen muoto
DE60209708D1 (de) Azol- oder triazol-derivate, verfahren zu deren herstellung und ihre verwendung als fungizide
ATE38516T1 (de) 4(5)-substituierte imidazole.
FI964114A (fi) Uusia 1-(5-metaanisulfonamidoindolyyli-2-karbonyyli)-4-(3-(1-metyylietyyliamino)-2-pyridinyyli)piperatsiinin kiteisiä muotoja
LV11461A (lv) Dihloraizvietotie imidazola atvasinajumi ka pretsenisu lidzekli
KR840008801A (ko) 아졸 유도체의 제조방법