ATE197951T1 - Neue imidazol derivate, ihre herstellung und therapeutische verwendung - Google Patents
Neue imidazol derivate, ihre herstellung und therapeutische verwendungInfo
- Publication number
- ATE197951T1 ATE197951T1 AT93914482T AT93914482T ATE197951T1 AT E197951 T1 ATE197951 T1 AT E197951T1 AT 93914482 T AT93914482 T AT 93914482T AT 93914482 T AT93914482 T AT 93914482T AT E197951 T1 ATE197951 T1 AT E197951T1
- Authority
- AT
- Austria
- Prior art keywords
- preparation
- therapeutic use
- pct
- imidazole derivatives
- new imidazole
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/84—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Anesthesiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9200189A FR2686084B1 (fr) | 1992-01-10 | 1992-01-10 | Nouveaux derives de l'imidazole, leur preparation et leurs applications therapeutiques. |
PCT/FR1993/000015 WO1993014070A2 (fr) | 1992-01-10 | 1993-01-08 | Nouveaux derives de l'imidazole, leur preparation et leurs applications therapeutiques |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE197951T1 true ATE197951T1 (de) | 2000-12-15 |
Family
ID=9425513
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT93914482T ATE197951T1 (de) | 1992-01-10 | 1993-01-08 | Neue imidazol derivate, ihre herstellung und therapeutische verwendung |
Country Status (12)
Country | Link |
---|---|
US (2) | US5559113A (de) |
EP (1) | EP0597088B1 (de) |
JP (1) | JP3829259B2 (de) |
AT (1) | ATE197951T1 (de) |
CA (1) | CA2105867C (de) |
DE (1) | DE69329727T2 (de) |
DK (1) | DK0597088T3 (de) |
ES (1) | ES2154270T3 (de) |
FR (1) | FR2686084B1 (de) |
GR (1) | GR3035414T3 (de) |
PT (1) | PT597088E (de) |
WO (1) | WO1993014070A2 (de) |
Families Citing this family (42)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9127304D0 (en) * | 1991-12-23 | 1992-02-19 | Boots Co Plc | Therapeutic agents |
GB9303825D0 (en) * | 1993-02-25 | 1993-04-14 | Smithkline Beecham Plc | Novel compounds |
GB9312893D0 (en) * | 1993-06-22 | 1993-08-04 | Boots Co Plc | Therapeutic agents |
NZ276883A (en) * | 1993-11-15 | 1998-08-26 | Schering Corp | 1h-imidazol-4-yl)alkyl]benzene derivatives |
US5525621A (en) * | 1994-05-20 | 1996-06-11 | Cytos Pharmaceuticals Llc | Imidazole derivatives as protective agents in reperfusion injury and severe inflammatory responses |
FR2732017B1 (fr) * | 1995-03-21 | 2000-09-22 | Inst Nat Sante Rech Med | Nouveaux derives de l'imidazole antagonistes et/ou agonistes du recepteur h3 de l'histamine, leur preparation et leurs applications therapeutiques |
ATE213412T1 (de) * | 1995-05-30 | 2002-03-15 | Gliatech Inc | 1h-4(5)substituierte imidazolderivate |
US5652258A (en) * | 1995-05-30 | 1997-07-29 | Gliatech, Inc. | 2-(4-imidazoyl) cyclopropyl derivatives |
US6448282B1 (en) | 1995-05-30 | 2002-09-10 | Gliatech, Inc. | 1H-4(5)-substituted imidazole derivatives |
WO1997029092A1 (en) * | 1996-02-09 | 1997-08-14 | James Black Foundation Limited | Histamine h3 receptor ligands |
US6451816B1 (en) | 1997-06-20 | 2002-09-17 | Klinge Pharma Gmbh | Use of pyridyl alkane, pyridyl alkene and/or pyridyl alkine acid amides in the treatment of tumors or for immunosuppression |
DE19624659A1 (de) | 1996-06-20 | 1998-01-08 | Klinge Co Chem Pharm Fab | Neue Pyridylalken- und Pyridylalkinsäureamide |
GB9715814D0 (en) * | 1997-07-25 | 1997-10-01 | Black James Foundation | Histamine H3 receptor ligands |
GB2344588B (en) * | 1997-07-25 | 2001-11-14 | Black James Foundation | 1H-4(5)-substituted imidazole derivatives their preparation and their use as histamine H 3 receptor ligands |
US6407132B1 (en) * | 1997-07-25 | 2002-06-18 | James Black Foundation Limited | Substituted imidazole derivatives and their use as histamine H3 receptor ligands |
US5990147A (en) * | 1997-11-07 | 1999-11-23 | Schering Corporation | H3 receptor ligands of the phenyl-alkyl-imidazoles type |
ES2188029T3 (es) * | 1997-11-07 | 2003-06-16 | Schering Corp | Fenil-alquil-imidazoles como antagonistas del receptor h3. |
US6034251A (en) * | 1997-11-07 | 2000-03-07 | Schering Corporation | Phenyl-alkyl-imidazoles |
TW421645B (en) * | 1997-11-07 | 2001-02-11 | Schering Corp | H3 receptor ligands of the phenyl-alkyl-imidazoles type |
DE19756235A1 (de) | 1997-12-17 | 1999-07-01 | Klinge Co Chem Pharm Fab | Neue piperidinylsubstituierte Pyridylalkan- alken- und -alkincarbonsäureamide |
US6903118B1 (en) | 1997-12-17 | 2005-06-07 | Klinge Pharma Gmbh | Piperazinyl-substituted pyridylalkane, alkene and alkine carboxamides |
DE19756212A1 (de) | 1997-12-17 | 1999-07-01 | Klinge Co Chem Pharm Fab | Neue, mit einem cyclischen Imid substituierte Pyridylalkan-, alken- und -alkincarbonsäureamide |
GB9803536D0 (en) * | 1998-02-19 | 1998-04-15 | Black James Foundation | Histamine H,receptor ligands |
US6136559A (en) * | 1998-10-07 | 2000-10-24 | Ortho Pharmaceutical Corporation | DNA encoding as human histamine receptor of the H3 subtype |
US6100279A (en) * | 1998-11-05 | 2000-08-08 | Schering Corporation | Imidazoylalkyl substituted with a five, six or seven membered heterocyclic ring containing one nitrogen atom |
EP1147092A1 (de) | 1999-01-18 | 2001-10-24 | Novo Nordisk A/S | Substituierte imidazole, ihre herstellung und verwendung |
EP1031564A1 (de) | 1999-02-26 | 2000-08-30 | Klinge Pharma GmbH | Hemmer der Nicotinamidmonononukleotide-Bildung und deren Verwendung zur Krebstherapie |
US6211182B1 (en) * | 1999-03-08 | 2001-04-03 | Schering Corporation | Imidazole compounds substituted with a six or seven membered heterocyclic ring containing two nitrogen atoms |
US6908926B1 (en) | 1999-04-16 | 2005-06-21 | Novo Nordisk A/S | Substituted imidazoles, their preparation and use |
US6437147B1 (en) | 2000-03-17 | 2002-08-20 | Novo Nordisk | Imidazole compounds |
US6610721B2 (en) | 2000-03-17 | 2003-08-26 | Novo Nordisk A/S | Imidazo heterocyclic compounds |
US20010047100A1 (en) * | 2000-04-26 | 2001-11-29 | Kjaersgaard Hans Joergen | Chiral imidazoyl intermediates for the synthesis of 2-(4-imidazoyl)-cyclopropyl derivatives |
JP2004506012A (ja) | 2000-08-17 | 2004-02-26 | グリアテツク・インコーポレイテツド | H3剤としての新規脂環式イミダゾール |
AR032895A1 (es) * | 2000-09-20 | 2003-12-03 | Schering Corp | Imidazoles sustituidos como agonistas o antagonistas duales h1 y h3 de histamina |
US20070299093A1 (en) * | 2005-01-27 | 2007-12-27 | Alma Mater Studiorum-Universitá Di Bologna | Organic Compounds Useful for the Treatment of Alzheimer's Disease, Their Use and Method of Preparation |
WO2006080043A2 (en) | 2005-01-27 | 2006-08-03 | Alma Mater Studiorum- Universita' Di Bologna | Organic compounds useful for the treatment of alzheimer's disease, their use and method of preparation |
EP1707203A1 (de) | 2005-04-01 | 2006-10-04 | Bioprojet | Verwendung von Alkylaminen, die kein Imidazole enthalten, als Histamin H3 Rezeptor Liganden, zur Behandlung von Morbus Parkinson, obstruktiver Schlafapnoe, vaskularer Demenz, Demenz mit Lewy Korpen |
EP1879864A1 (de) * | 2005-04-20 | 2008-01-23 | Janssen Pharmaceutica N.V. | Fluorierte pyridin-n-oxide als thrombinmodulatoren und verfahren zur n-oxidation von stickstoffhaltigen heteroarylverbindungen |
EP1717235A3 (de) | 2005-04-29 | 2007-02-28 | Bioprojet | Phenoxypropylpiperidine und -pyrrolidine und ihre Verwendung als Liganden für den Histamin H3-Rezeptor |
EP1717233A1 (de) * | 2005-04-29 | 2006-11-02 | Bioprojet | Liganden für den Histamin H3-Rezeptor und ihre therapeutische Anwendung |
JP6062077B2 (ja) * | 2013-03-12 | 2017-01-18 | バイオ−ファーム ソリューションズ カンパニー リミテッド | 小児てんかん及びてんかん関連症侯群の予防又は治療用フェニルカルバメート化合物{phenylcarbamatecompoundsforuseinpreventingortreatingpediatricepilesyandepilesy−relatedsyndromes} |
JP7485502B2 (ja) * | 2016-05-04 | 2024-05-16 | ベ.セ.イ. ファルマ | プロテインキナーゼ阻害剤としてのアデニン誘導体 |
Family Cites Families (34)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE276541C (de) * | ||||
DE332955C (de) * | 1914-06-10 | 1921-02-15 | Otto Gerngross Dr | Verfahren zur Darstellung von 5(4)-Arylparaffinaminoparaffinimidazolen |
DE701322C (de) * | 1938-05-11 | 1941-01-14 | Chemische Ind Ges | Verfahren zur Darstellung von Imidazolin- und Tetrahydropyrimidinverbindungen |
US2301532A (en) * | 1938-08-18 | 1942-11-10 | Parke Davis & Co | Biological product and process of obtaining same |
US2376424A (en) * | 1940-12-23 | 1945-05-22 | Parke Davis & Co | Biological product and process of obtaining same |
FR1220002A (fr) * | 1952-08-28 | 1960-05-20 | Abbott Lab | Procédé de préparation de 4 (5)-aryloxy-méthylimidazoles halosubstitués |
GB1305547A (de) * | 1969-10-29 | 1973-02-07 | ||
GB1305548A (de) * | 1969-10-29 | 1973-02-07 | ||
GB1305549A (de) * | 1969-10-29 | 1973-02-07 | ||
GB1341375A (en) * | 1969-11-19 | 1973-12-19 | Smith Kline French Lab | Aminoalkylimidazoles and process for their production |
CA938556A (en) * | 1970-06-25 | 1973-12-18 | Smith Kline And French Laboratories Limited | Pharmaceutical compositions containing thiourea derivatives |
GB1338169A (en) * | 1971-03-09 | 1973-11-21 | Smith Kline French Lab | Ureas thioureas and guanidines |
US4072748A (en) * | 1972-09-05 | 1978-02-07 | Smith Kline & French Laboratories Limited | Certain guanidine compounds, and their use as inhibitors of histamine activity |
GB1531221A (en) * | 1974-09-02 | 1978-11-08 | Smith Kline French Lab | Process for preparing guanidine derivatives |
US4154834A (en) * | 1975-12-29 | 1979-05-15 | Smith Kline & French Laboratories Limited | Substituted isocytosines having histamine H2 -antagonist activity |
AU514574B2 (en) * | 1977-04-21 | 1981-02-19 | Smithkline Corporation | Process for preparing 4-substituted imidazole compounds |
US4233302A (en) * | 1977-12-23 | 1980-11-11 | Glaxo Group Limited | Amine derivatives and pharmaceutical compositions containing them |
DK221081A (da) * | 1980-05-31 | 1981-12-01 | Smith Kline French Lab | Fremgangsmaade til fremstilling af heterocyklylalkylanidiner mellemprodukter til anvendelse ved denne fremgangsmaade og en fremgangsmaade til fremstilling af disse mellemprodukter |
DE3048266A1 (de) * | 1980-12-20 | 1982-07-29 | Bayer Ag, 5090 Leverkusen | Substituierte 1-azolyl-butan-2one, verfahren zu ihrer herstellung und ihre verwendung als fungizide sowie als zwischenprodukte |
GB2110663B (en) * | 1981-12-04 | 1985-08-07 | Farmos Group Ltd | Imidazole derivatives |
JO1275B1 (en) * | 1982-12-03 | 1985-04-20 | هنري براون ثوماس | Chemical process |
US4489089A (en) * | 1983-04-06 | 1984-12-18 | American Cyanamid Company | Substituted N-[ω-(1H-imidazol-1-yl)alkyl]-amides |
EP0199845B1 (de) * | 1985-04-02 | 1990-08-01 | HEUMANN PHARMA GMBH & CO | Imidazolylalkylguanidinderivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel |
NL8601585A (nl) * | 1986-06-19 | 1988-01-18 | Vereniging Voor Christelijk Wetenschappelijk Onderwijs | N-(2-gesubstitueerde alkyl)-n-imidazol-4-yl alkyl guanidine. |
DE3631334A1 (de) * | 1986-09-15 | 1988-03-17 | Heumann Pharma Gmbh & Co | Neue imidazolylguanidinderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
US4996221A (en) * | 1987-01-13 | 1991-02-26 | The Board Of Trustees Of The Leland Stanford Junior University | Histamine derivatives as immune modulators |
EP0291172B1 (de) * | 1987-04-14 | 1992-11-19 | Glaxo Group Limited | Keton-Derivate |
NZ225583A (en) * | 1987-08-06 | 1991-07-26 | Merck & Co Inc | Process for purifying hepatitis a virions (hav) |
DE3726381A1 (de) * | 1987-08-07 | 1989-02-16 | Heumann Pharma Gmbh & Co | Guanidincarbonsaeureester, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
GB8723157D0 (en) * | 1987-10-02 | 1987-11-04 | Beecham Group Plc | Compounds |
NL8800998A (nl) * | 1988-04-18 | 1989-11-16 | Cedona Pharm Bv | Werkwijze voor het bereiden van een al of niet gesubstitueerd 4(5)-(omega-aminoalkyl) imidazool. |
FR2630328B1 (fr) * | 1988-04-22 | 1990-08-24 | Inst Nat Sante Rech Med | Derive de l'histamine, sa preparation et son application en therapeutique |
CA2047041A1 (en) * | 1990-07-18 | 1992-01-19 | John A. Lewis | Process for purification of hepatitis-a virus capsids |
IT1248075B (it) * | 1991-06-18 | 1995-01-05 | Sclavo Spa | Processo per la purificazione del virus dell'epatite a (hav), virus cosi` purificato e composizioni vaccinali che lo contengono. |
-
1992
- 1992-01-10 FR FR9200189A patent/FR2686084B1/fr not_active Expired - Fee Related
-
1993
- 1993-01-08 WO PCT/FR1993/000015 patent/WO1993014070A2/fr active IP Right Grant
- 1993-01-08 JP JP51219193A patent/JP3829259B2/ja not_active Expired - Fee Related
- 1993-01-08 EP EP93914482A patent/EP0597088B1/de not_active Expired - Lifetime
- 1993-01-08 PT PT93914482T patent/PT597088E/pt unknown
- 1993-01-08 ES ES93914482T patent/ES2154270T3/es not_active Expired - Lifetime
- 1993-01-08 CA CA002105867A patent/CA2105867C/en not_active Expired - Fee Related
- 1993-01-08 US US08/117,161 patent/US5559113A/en not_active Ceased
- 1993-01-08 DK DK93914482T patent/DK0597088T3/da active
- 1993-01-08 AT AT93914482T patent/ATE197951T1/de not_active IP Right Cessation
- 1993-01-08 DE DE69329727T patent/DE69329727T2/de not_active Expired - Fee Related
-
1996
- 1996-06-14 US US08/663,679 patent/US5708171A/en not_active Expired - Fee Related
-
2001
- 2001-02-14 GR GR20010400244T patent/GR3035414T3/el not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
US5559113A (en) | 1996-09-24 |
EP0597088B1 (de) | 2000-12-06 |
DK0597088T3 (da) | 2001-04-09 |
FR2686084A1 (fr) | 1993-07-16 |
FR2686084B1 (fr) | 1995-12-22 |
WO1993014070A3 (fr) | 1993-08-19 |
DE69329727D1 (de) | 2001-01-11 |
ES2154270T3 (es) | 2001-04-01 |
JP3829259B2 (ja) | 2006-10-04 |
PT597088E (pt) | 2001-04-30 |
US5708171A (en) | 1998-01-13 |
GR3035414T3 (en) | 2001-05-31 |
CA2105867C (en) | 2005-07-12 |
DE69329727T2 (de) | 2001-04-12 |
JPH06506003A (ja) | 1994-07-07 |
EP0597088A1 (de) | 1994-05-18 |
WO1993014070A2 (fr) | 1993-07-22 |
CA2105867A1 (en) | 1993-07-11 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ATE197951T1 (de) | Neue imidazol derivate, ihre herstellung und therapeutische verwendung | |
DE69331190D1 (de) | Überbrückte azabicyclische derivate als substanz p antagonisten | |
DE69622031T2 (de) | INDOLDERIVATE ALS cGMP-PDE INHIBITOREN | |
KR960701055A (ko) | 인터로이킨-1 및 종양 괴사 인자 억제 활성을 지닌 피라졸로트리아진 (pyrazol itriazines with interleukin-1 and tumour necrosis factor in-hibitory actvity) | |
FI935674A (fi) | Pyratsolit ja pyratsolopyrimidiinit | |
TR200101499T1 (tr) | Azepinoindol türevleri, hazırlanmaları ve kullanımları. | |
DE69327536T2 (de) | Fibrinogenrezeptor-antagonisten | |
SE9504661D0 (sv) | New compounds | |
DE69413542T2 (de) | Perhydroisoindolderivate als substanz p antagonisten | |
DK0783501T3 (da) | Pyrimidonderivater med anti-fungal aktivitet | |
CA2176935A1 (fr) | Arylpiperazines derivees d'indole comme ligands pour les recepteurs 5 ht1-like 5 ht1b et 5 ht1d | |
DE69316910D1 (de) | Neue vitamin d derivate | |
LV11899A (lv) | Jauni adenozina atvasinajumi to iegusanas panemiens | |
MX9303605A (es) | Derivados de azabicicloheptano n-substituidas, su obtencion y uso. | |
DE69330601D1 (de) | Serotoninergische ergolin derivate | |
SE9504662D0 (sv) | New compounds | |
ATE170851T1 (de) | Guanidinothiazolederivate und ihre anwendung als h2-rezeptor-antagonisten | |
MX9603199A (es) | Antagonistas de receptores a endotelina. | |
ATE184875T1 (de) | Imidazo(1,2-a>indeno(1,2-e>pyrazin-2-carbonsäur derivate, ihre herstellung und sie enthaltende arzneimittel | |
TR199900013T2 (xx) | Yeni bile�ikler. | |
TW371661B (en) | Novel intermediates and their use to prepare N,N'-bridged bisindolylmaleimides | |
TR200000154T2 (tr) | 2,4,4-Trisübstitüe-1,3-Dioksolan mantar önleyiciler. | |
FI955142A (fi) | Bentso(f)kinoksaliinidionijohdannaisia, niiden valmistus ja käyttö lääkkeinä |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
UEP | Publication of translation of european patent specification | ||
REN | Ceased due to non-payment of the annual fee |