GB2344588B - 1H-4(5)-substituted imidazole derivatives their preparation and their use as histamine H 3 receptor ligands - Google Patents

1H-4(5)-substituted imidazole derivatives their preparation and their use as histamine H 3 receptor ligands

Info

Publication number
GB2344588B
GB2344588B GB0000112A GB0000112A GB2344588B GB 2344588 B GB2344588 B GB 2344588B GB 0000112 A GB0000112 A GB 0000112A GB 0000112 A GB0000112 A GB 0000112A GB 2344588 B GB2344588 B GB 2344588B
Authority
GB
United Kingdom
Prior art keywords
histamine
preparation
receptor ligands
imidazole derivatives
substituted imidazole
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
GB0000112A
Other versions
GB2344588A (en
GB0000112D0 (en
Inventor
Matthew John Tozer
Sarkis Barret Kalindjian
Ian Duncan Linney
Katherine Isobel Mary Steel
Michael John Pether
Tracey Cooke
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
James Black Foundation Ltd
Original Assignee
James Black Foundation Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9715814.1A external-priority patent/GB9715814D0/en
Application filed by James Black Foundation Ltd filed Critical James Black Foundation Ltd
Priority to GB0000112A priority Critical patent/GB2344588B/en
Publication of GB0000112D0 publication Critical patent/GB0000112D0/en
Publication of GB2344588A publication Critical patent/GB2344588A/en
Application granted granted Critical
Publication of GB2344588B publication Critical patent/GB2344588B/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
GB0000112A 1997-07-25 1998-07-14 1H-4(5)-substituted imidazole derivatives their preparation and their use as histamine H 3 receptor ligands Expired - Fee Related GB2344588B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB0000112A GB2344588B (en) 1997-07-25 1998-07-14 1H-4(5)-substituted imidazole derivatives their preparation and their use as histamine H 3 receptor ligands

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9715814.1A GB9715814D0 (en) 1997-07-25 1997-07-25 Histamine H3 receptor ligands
GB0000112A GB2344588B (en) 1997-07-25 1998-07-14 1H-4(5)-substituted imidazole derivatives their preparation and their use as histamine H 3 receptor ligands
PCT/GB1998/002067 WO1999005114A2 (en) 1997-07-25 1998-07-14 1h-4(5)-substituted imidazole derivatives, their preparation and their use as histamine h3 receptor ligands

Publications (3)

Publication Number Publication Date
GB0000112D0 GB0000112D0 (en) 2000-02-23
GB2344588A GB2344588A (en) 2000-06-14
GB2344588B true GB2344588B (en) 2001-11-14

Family

ID=26243332

Family Applications (1)

Application Number Title Priority Date Filing Date
GB0000112A Expired - Fee Related GB2344588B (en) 1997-07-25 1998-07-14 1H-4(5)-substituted imidazole derivatives their preparation and their use as histamine H 3 receptor ligands

Country Status (1)

Country Link
GB (1) GB2344588B (en)

Citations (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3444175A (en) * 1966-11-09 1969-05-13 Merck & Co Inc Certain picolylmethyl sulfones
DE2061489A1 (en) * 1969-12-15 1971-07-29 Merck & Co Ine, Rahway, N J (V St A) Anti gout agents and anti hyperurikami see agents containing 4 (5) fluoromethyl imidazole
US3682949A (en) * 1969-07-22 1972-08-08 Lewis H Sarett 2-aryl-5(or 4-)nitroimidazoles
FR2227869A1 (en) * 1973-05-03 1974-11-29 Smith Kline French Lab
US3901908A (en) * 1970-12-28 1975-08-26 Ciba Geigy Corp 2-alkyl- and 2-cycloalkyl-4,5-bis-phenyl-imidazoles
GB1421792A (en) * 1973-05-17 1976-01-21 Smith Kline French Lab Heterocyclic substituted-1, 1-diamino-ethylene derivatives methods for their preparation and compositions containing them
US4147698A (en) * 1978-07-13 1979-04-03 E. R. Squibb & Sons, Inc. 3-(Heterocyclicalkylamino)benzisothiazole-1,1-dioxides
WO1993014070A2 (en) * 1992-01-10 1993-07-22 Institut National De La Sante Et De La Recherche Medicale Novel imidazole derivatives, their preparation and therapeutic applications
WO1995014007A1 (en) * 1993-11-15 1995-05-26 Schering Corporation Phenyl-alkyl imidazoles as h3-receptor antagonists
WO1996029315A2 (en) * 1995-03-21 1996-09-26 Institut National De La Sante Et De La Recherche Medicale Imidazole derivatives as histamine receptor h3 (ant)agonists
WO1996038142A1 (en) * 1995-05-30 1996-12-05 Gliatech, Inc. 1h-4(5)-substituted imidazole derivatives
WO1997029092A1 (en) * 1996-02-09 1997-08-14 James Black Foundation Limited Histamine h3 receptor ligands

Patent Citations (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3444175A (en) * 1966-11-09 1969-05-13 Merck & Co Inc Certain picolylmethyl sulfones
US3682949A (en) * 1969-07-22 1972-08-08 Lewis H Sarett 2-aryl-5(or 4-)nitroimidazoles
DE2061489A1 (en) * 1969-12-15 1971-07-29 Merck & Co Ine, Rahway, N J (V St A) Anti gout agents and anti hyperurikami see agents containing 4 (5) fluoromethyl imidazole
US3901908A (en) * 1970-12-28 1975-08-26 Ciba Geigy Corp 2-alkyl- and 2-cycloalkyl-4,5-bis-phenyl-imidazoles
FR2227869A1 (en) * 1973-05-03 1974-11-29 Smith Kline French Lab
GB1421792A (en) * 1973-05-17 1976-01-21 Smith Kline French Lab Heterocyclic substituted-1, 1-diamino-ethylene derivatives methods for their preparation and compositions containing them
US4147698A (en) * 1978-07-13 1979-04-03 E. R. Squibb & Sons, Inc. 3-(Heterocyclicalkylamino)benzisothiazole-1,1-dioxides
WO1993014070A2 (en) * 1992-01-10 1993-07-22 Institut National De La Sante Et De La Recherche Medicale Novel imidazole derivatives, their preparation and therapeutic applications
WO1995014007A1 (en) * 1993-11-15 1995-05-26 Schering Corporation Phenyl-alkyl imidazoles as h3-receptor antagonists
WO1996029315A2 (en) * 1995-03-21 1996-09-26 Institut National De La Sante Et De La Recherche Medicale Imidazole derivatives as histamine receptor h3 (ant)agonists
WO1996038142A1 (en) * 1995-05-30 1996-12-05 Gliatech, Inc. 1h-4(5)-substituted imidazole derivatives
WO1997029092A1 (en) * 1996-02-09 1997-08-14 James Black Foundation Limited Histamine h3 receptor ligands

Non-Patent Citations (9)

* Cited by examiner, † Cited by third party
Title
CLITHEROW J W ET AL:BIOORGANIC & MEDICINAL CHEMISTRY LETTERSvol.6 no.7 1996 pgs 833-838 XP002089499 *
GAUTHIER J Y ET AL: BIOORGANIC & MEDICINAL CHEMISTRY LETTERSvol.6 no.1 1996 pgs 87-92 XP002080037 *
HERKE J & SCHUNACK W: ARCHIV DER PHARMAZIE vol.312, 1979, pg35-39 XP002080034 *
KELLEY J L ET AL: JOURNAL OF PHARMACEUTICAL SCIENCES, vol.70no.3 1981 XP002080035 *
SAIKACHI H ET AL: CHEMICAL & PHARMACEUTICAL BULLETIN VOL.30 NO.11, 1982, pgs 4199-4204 *
SANTILLI AA ET AL: JOURNAL OF MEDICINAL CHEMISTRY vol.31 no.7 1988 pgs 1479-1486 XP002089498 *
SUPURAN C T ET AL: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY vol.31 no.6 1996 pgs 431-438 XP004040067 *
VAN DER STELT ET AL: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRYvol.13 no.3 1978 pgs 251-253 XP002080033 *
YOUNG R C ET AL: JOURNAL OF MEDICINAL CHEMISTRY vol.29 no.1 1986 pages 44-49 XP002089497 *

Also Published As

Publication number Publication date
GB2344588A (en) 2000-06-14
GB0000112D0 (en) 2000-02-23

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Legal Events

Date Code Title Description
PCNP Patent ceased through non-payment of renewal fee

Effective date: 20080714