DE69816284D1 - Azol-verbindungen, ihre herstellung und ihre verwendung - Google Patents
Azol-verbindungen, ihre herstellung und ihre verwendungInfo
- Publication number
- DE69816284D1 DE69816284D1 DE69816284T DE69816284T DE69816284D1 DE 69816284 D1 DE69816284 D1 DE 69816284D1 DE 69816284 T DE69816284 T DE 69816284T DE 69816284 T DE69816284 T DE 69816284T DE 69816284 D1 DE69816284 D1 DE 69816284D1
- Authority
- DE
- Germany
- Prior art keywords
- production
- vivo
- eliminated
- quaternized
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Coloring (AREA)
Applications Claiming Priority (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP8086397 | 1997-03-31 | ||
JP8086397 | 1997-03-31 | ||
JP18239597 | 1997-07-08 | ||
JP18239597 | 1997-07-08 | ||
JP33729997 | 1997-12-08 | ||
JP33729997 | 1997-12-08 | ||
PCT/JP1998/001441 WO1998043970A1 (en) | 1997-03-31 | 1998-03-30 | Azole compounds, their production and their use |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69816284D1 true DE69816284D1 (de) | 2003-08-14 |
DE69816284T2 DE69816284T2 (de) | 2004-05-27 |
Family
ID=27303408
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69816284T Expired - Fee Related DE69816284T2 (de) | 1997-03-31 | 1998-03-30 | Azol-verbindungen, ihre herstellung und ihre verwendung |
Country Status (11)
Country | Link |
---|---|
US (1) | US6407129B1 (de) |
EP (1) | EP0973768B1 (de) |
JP (1) | JP2000198773A (de) |
KR (1) | KR20010005792A (de) |
CN (1) | CN1251098A (de) |
AT (1) | ATE244715T1 (de) |
AU (1) | AU6520098A (de) |
CA (1) | CA2281875A1 (de) |
DE (1) | DE69816284T2 (de) |
RU (1) | RU2189982C2 (de) |
WO (1) | WO1998043970A1 (de) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE19751525C2 (de) | 1997-11-20 | 2003-02-13 | Bat Cigarettenfab Gmbh | Verfahren und Vorrichtung zur Regelung der Ausgangsfeuchte von Tabak |
AU5760999A (en) * | 1998-09-29 | 2000-04-17 | Takeda Chemical Industries Ltd. | Antimycotic drug composition |
WO2000030655A1 (en) | 1998-11-20 | 2000-06-02 | Bristol-Myers Squibb Company | Water soluble prodrugs of azole compounds |
US6235728B1 (en) | 1999-02-19 | 2001-05-22 | Bristol-Myers Squibb Company | Water-soluble prodrugs of azole compounds |
AU777859B2 (en) * | 1999-11-02 | 2004-11-04 | Basilea Pharmaceutica International Ag, Allschwil | N-substituted carbamoyloxyalkyl-azolium derivatives |
US6812238B1 (en) | 1999-11-02 | 2004-11-02 | Basilea Pharmaceutica Ag | N-substituted carbamoyloxyalkyl-azolium derivatives |
US6376548B1 (en) | 2000-01-28 | 2002-04-23 | Rohm And Haas Company | Enhanced propertied pesticides |
US20050159369A1 (en) * | 2003-08-20 | 2005-07-21 | Qtm Llc | Method of treatment of otitis externa |
US20070078116A1 (en) * | 2003-08-20 | 2007-04-05 | Fairfield Clinical Trials, Llc | Method of treatment of otitis externa |
JP4101852B2 (ja) | 2004-05-26 | 2008-06-18 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | シンナミド化合物 |
CA2580119A1 (en) | 2004-10-26 | 2006-05-04 | Eisai R & D Management Co., Ltd. | Amorphous object of cinnamide compound |
TWI370130B (en) | 2005-11-24 | 2012-08-11 | Eisai R&D Man Co Ltd | Two cyclic cinnamide compound |
KR20080069221A (ko) | 2005-11-24 | 2008-07-25 | 에자이 알앤드디 매니지먼트 가부시키가이샤 | 모르폴린 타입의 신나미드 화합물 |
TWI378091B (en) | 2006-03-09 | 2012-12-01 | Eisai R&D Man Co Ltd | Multi-cyclic cinnamide derivatives |
US7737141B2 (en) | 2006-07-28 | 2010-06-15 | Eisai R&D Management Co., Ltd. | Prodrug of cinnamide compound |
CL2008000582A1 (es) | 2007-02-28 | 2008-06-27 | Eisai R&D Man Co Ltd | Compuestos ciclicos derivados de oximorfolina condensados; farmacos que comprenden a dichos compuestos; y su uso para tratar enfermedad de alzheimer, demencia senil, sindrome de down o amiloidosis. |
EP1990617A1 (de) * | 2007-05-09 | 2008-11-12 | FOSS Analytical A/S | Bestimmung von Tanninen in der Weinherstellung |
TW200916469A (en) | 2007-08-31 | 2009-04-16 | Eisai R & Amp D Man Co Ltd | Multi-cyclic compounds |
US7935815B2 (en) | 2007-08-31 | 2011-05-03 | Eisai R&D Management Co., Ltd. | Imidazoyl pyridine compounds and salts thereof |
JP5453093B2 (ja) * | 2007-09-05 | 2014-03-26 | 株式会社ポーラファルマ | 抗真菌医薬組成物 |
US11225463B2 (en) | 2016-11-28 | 2022-01-18 | Cellix Bio Private Limited | Compositions and methods for the treatment of oral infectious diseases |
IL287622B (en) * | 2016-11-28 | 2022-07-01 | Cellix Bio Private Ltd | Preparations and methods for treating fungal infections |
EP3584245A4 (de) * | 2017-02-17 | 2020-08-26 | Wuhan LL Science And Technology Development Co., Ltd. | Antibakterielles derivat aus triazol sowie pharmazeutische zusammensetzung und verwendung davon |
US20200138964A1 (en) * | 2017-04-25 | 2020-05-07 | Seikagaku Corporation | Tertiary amine compound or imine compound-polymer conjugate and production method therefor |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3998815A (en) | 1974-06-24 | 1976-12-21 | Interx Research Corporation | 1-hydrocarbonoyloxymethyl-3-carbamoyl or 3-carboethoxy-pyridinium salts |
US4061722A (en) * | 1976-04-26 | 1977-12-06 | Interx Research Corporation | Selected quaternary ammonium salts of pilocarpine useful in reducing intraocular pressure in warm-blooded animals |
EP0548553A1 (de) | 1991-11-25 | 1993-06-30 | Takeda Chemical Industries, Ltd. | Optisch aktive Azolverbindungen, ihre Herstellung und Anwendung |
TW218017B (de) * | 1992-04-28 | 1993-12-21 | Takeda Pharm Industry Co Ltd | |
JPH08104676A (ja) * | 1993-09-24 | 1996-04-23 | Takeda Chem Ind Ltd | アゾール化合物、その製造方法及び用途 |
TW297813B (de) * | 1993-09-24 | 1997-02-11 | Takeda Pharm Industry Co Ltd | |
TW318841B (de) * | 1995-02-17 | 1997-11-01 | Takeda Pharm Industry Co Ltd | |
AU4675596A (en) * | 1995-02-17 | 1996-09-04 | Takeda Chemical Industries Ltd. | Azole compounds, their production and use |
EP0829478A3 (de) | 1996-09-09 | 1998-03-25 | F. Hoffmann-La Roche Ag | N-Benzylimidazolium und N-Benzyltriazolium Derivate, deren Herstellung und deren Verwendung als fungizides und anti-mykotisches Mittel |
-
1998
- 1998-03-30 US US09/381,479 patent/US6407129B1/en not_active Expired - Fee Related
- 1998-03-30 AU AU65200/98A patent/AU6520098A/en not_active Abandoned
- 1998-03-30 CN CN98803552A patent/CN1251098A/zh active Pending
- 1998-03-30 CA CA002281875A patent/CA2281875A1/en not_active Abandoned
- 1998-03-30 RU RU99123064/04A patent/RU2189982C2/ru not_active IP Right Cessation
- 1998-03-30 DE DE69816284T patent/DE69816284T2/de not_active Expired - Fee Related
- 1998-03-30 WO PCT/JP1998/001441 patent/WO1998043970A1/en active IP Right Grant
- 1998-03-30 KR KR1019997008864A patent/KR20010005792A/ko not_active Application Discontinuation
- 1998-03-30 EP EP98911100A patent/EP0973768B1/de not_active Expired - Lifetime
- 1998-03-30 AT AT98911100T patent/ATE244715T1/de not_active IP Right Cessation
-
2000
- 2000-02-28 JP JP2000056015A patent/JP2000198773A/ja not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
US6407129B1 (en) | 2002-06-18 |
ATE244715T1 (de) | 2003-07-15 |
DE69816284T2 (de) | 2004-05-27 |
CA2281875A1 (en) | 1998-10-08 |
EP0973768A1 (de) | 2000-01-26 |
CN1251098A (zh) | 2000-04-19 |
EP0973768B1 (de) | 2003-07-09 |
JP2000198773A (ja) | 2000-07-18 |
WO1998043970A1 (en) | 1998-10-08 |
RU2189982C2 (ru) | 2002-09-27 |
KR20010005792A (ko) | 2001-01-15 |
AU6520098A (en) | 1998-10-22 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DE69816284D1 (de) | Azol-verbindungen, ihre herstellung und ihre verwendung | |
TR199802693T2 (xx) | De�i�tirilmi� 3,5-difenil-1,2,4-triazoller ve eczasal metal kelatorlar olarak kullan�m�. | |
DE69329727D1 (de) | Neue imidazol derivate, ihre herstellung und therapeutische verwendung | |
DE60044395D1 (de) | Arylsubstituierte pyrazole, imidazole, oxazole, thiazole und pyrrole, sowie deren verwendung | |
WO2001038324A3 (en) | Imidazole derivatives and their use as raf kinase inhibitors | |
TR199801350T2 (xx) | Yeni sikloalkil ikameli imidazoller. | |
BG101112A (en) | The use of heterocyclic compounds | |
WO1998028282A3 (en) | OXYGEN OR SULFUR CONTAINING 5-MEMBERED HETEROAROMATICS AS FACTOR Xa INHIBITORS | |
TR199801360T2 (xx) | Yeni ikameli imidazol bile�imleri. | |
DE60012188D1 (de) | Fungizide | |
AU1676200A (en) | Polyhydroxylated heterocyclic derivatives as anti-coagulants | |
ZA908301B (en) | Use of substituted imidazolas | |
EP0834253A3 (de) | Antimikrobielle Zusammensetzung. | |
BG105840A (en) | Heterocyclic benzenesulphonamide compounds as bradykinine antagonists | |
WO2000061585A3 (en) | 1,3-dipolar cycloadditions to polypyrrolic macrocycles | |
PT1157030E (pt) | Complexos equinocandina/hidrato de carbono | |
AR045991A2 (es) | Compuesto de urea | |
MY103241A (en) | Imidazole and 1,2,4 triazole derivatives | |
KR970707108A (ko) | 항염증제로 유용한, 복소환부를 갖는 디-t-부틸페놀 화합물(DI-TERT-BUTYLPHENOL COMPOUNDS WITH HETEROCYCLIC MOIETY, USEFUL AS ANTI-INFLAMMATORY AGENTS) | |
ATE219623T1 (de) | Antimikrobielle lösungen | |
TR200002242T2 (tr) | 5-(2-İmidazolinilamino)-benzimidazol türevleri, bunların hazırlanması ve metabolik kararlılığı gelişmiş alfa-adrenoseptör agonistleri olarak kullanımları. | |
TR199802033T2 (xx) | Böcek öldürücü siprodinil ve miklobutanil bileşimi. | |
AP1567A (en) | Echinocandin derivatives, preparation method and application as anti-fungal agents. | |
IT1296924B1 (it) | Composti diolici intermedi per la preparazione di composti ad attivita' antimicotica | |
TR200001941T1 (tr) | TNF ve PDE-IV önleyici aktiviteye sahip heterosiklik bileşiklerin N-oksitleri. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8327 | Change in the person/name/address of the patent owner |
Owner name: TAKEDA PHARMACEUTICAL CO. LTD., OSAKA, JP |
|
8339 | Ceased/non-payment of the annual fee |