KR20040063167A - 처리된 리포애스퍼레이트 세포로 환자를 치료하기 위한시스템 및 방법 - Google Patents
처리된 리포애스퍼레이트 세포로 환자를 치료하기 위한시스템 및 방법 Download PDFInfo
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Abstract
Description
체중 지수 상태 | 얻어진 조직의 양 (g) | 총 세포 수율 |
보통 | 641±142 | 2.1±0.4 |
비만 | 1,225±173 | 2.4±0.5 |
p 값 | 0.03 | 0.6 |
Claims (92)
- (a) 조직 수거 시스템을 제공하는 단계;(b) 조직 수거 시스템을 사용하여 환자로부터 소정 농도의 줄기 세포를 갖는 지방 조직을 수거하는 단계;(c) 지방 조직의 적어도 일부분을 처리하여 처리 전의 지방 조직의 줄기 세포의 농도와 다른 농도의 줄기 세포를 수득하는 단계;(d) 환자에게 투여되기 전에 조직 수거 시스템으로부터 줄기 세포를 수거하지 않고 줄기 세포를 환자에게 투여하는 단계를 포함하는 환자의 치료 방법.
- 제1항에 있어서,상기 (b) 단계에서 지방 조직이 환자로부터 조직 수거 시스템으로 이동되고;상기 (c) 단계에서 지방 조직이 조직 수거 시스템 내에서 처리되고;상기 (d) 단계에서 줄기 세포가 조직 수거 시스템으로부터 환자에게로 투여되는 방법.
- 제1항에 있어서, 상기 (b) 단계가 환자에게 캐뉼라를 수거될 지방 조직의 근처에서 삽입하는 것 및 환자로부터 지방 조직을 흡입하는 것 중 하나 이상을 포함하는 방법.
- 제1항에 있어서,(e) 환자로부터 수거된 지방 조직을 여과하여 비-지방 조직으로부터 지방 조직을 분리하는 단계를 추가로 포함하는 방법.
- 제4항에 있어서, 상기 (e) 단계가 수거된 지방 조직을 지방 조직은 보유하고 비-지방 조직은 통과시키는 크기의 다수의 세공을 갖는 용기로 운반하는 것을 포함하는 방법.
- 제1항에 있어서, 상기 (c) 단계가 환자로부터 수거된 지방 조직을 분해하여 조직 내에 함유된 세포를 실질적으로 손상시키지 않고 조직을 분해하는 것을 포함하는 방법.
- 제6항에 있어서, 상기 (c) 단계가 지방 조직을 세포간 접촉을 방해하는 하나 이상의 효소와 혼합시키는 것을 포함하는 방법.
- 제7항에 있어서, 상기 지방 조직을 콜라게나제, 디스파제, 리파제, 리버라제 H1 및 트립신으로 이루어진 군으로부터 선택된 효소와 혼합하는 방법.
- 제6항에 있어서, 효소가 수거되지 않으면 지방 조직에 잔류하여 조직을 완전히 해체시키게 될 시간에 비하여 빨리 효소를 지방 조직으로부터 제거하는 방법.
- 제1항에 있어서, 상기 (c) 단계가, 줄기 세포에 성숙 지방세포 및 연결 조직이 실질적으로 없도록, 수거된 지방 조직으로부터 줄기 세포를 분리하는 것을 포함하는 방법.
- 제10항에 있어서, 상기 (c) 단계가 원심분리를 포함하는 방법.
- 제11항에 있어서, 상기 (c) 단계가 스피닝(spinning) 막 필터를 사용하는 것을 포함하는 방법.
- 제11항에 있어서,(e) 원심분리 후 줄기 세포를 재현탁시키는 단계를 추가로 포함하는 방법.
- 제1항에 있어서, 상기 (c) 단계가 지방 조직을 처리하여 보다 높은 농도의 줄기 세포를 수득하는 것을 포함하는 방법.
- 제1항에 있어서, 상기 (c) 단계가 적어도 일부분의 지방 조직을 분해하여 상기 다른 농도의 줄기 세포를 생성시키는 것을 포함하고, (d) 단계가 다른 일부분의 지방 조직과 상기 다른 농도의 줄기 세포를 배합시키고 이 배합물을 환자에게 투여하는 것을 포함하는 방법.
- 제15항에 있어서, 상기 적어도 일부분의 지방 조직의 부피와 상기 다른 일부분의 지방 조직의 부피의 차이가 25% 보다 큰 방법.
- 제15항에 있어서, 상기 적어도 일부분의 지방 조직의 부피와 상기 다른 일부분의 지방 조직의 부피의 차이가 100% 보다 큰 방법.
- 제15항에 있어서, 상기 분해가 하나 이상의 효소를 사용하여 수행되고, 상기 효소는 효소가 수거되지 않으면 지방 조직에 잔류하여 조직을 완전히 해체시키게 될 시간에 비하여 빨리 상기 적어도 일부분의 지방 조직으로부터 제거되는 방법.
- 제1항에 있어서, 상기 (c) 단계 후에 적어도 일부분의 지방 조직으로부터의 상기 농도의 줄기 세포와 다른 일부분의 지방조직을 혼합하고, (d) 단계가 상기 혼합물을 환자에게 투여하는 것을 포함하는 방법.
- 제19항에 있어서, 상기 분해가 하나 이상의 효소를 사용하여 수행되고, 상기 효소는 효소가 수거되지 않으면 지방 조직에 잔류하여 조직을 완전히 해체시키게 될 시간에 비하여 빨리 적어도 일부분의 지방 조직으로부터 제거되는 방법.
- 제19항에 있어서, 상기 적어도 일부분의 지방 조직의 부피와 상기 다른 일부분의 지방 조직의 부피의 차이가 50% 보다 큰 방법.
- 제19항에 있어서, 상기 적어도 일부분의 지방 조직의 부피와 상기 다른 일부분의 지방 조직의 부피의 차이가 150% 보다 큰 방법.
- 제1항에 있어서,(e) 환자의 줄기 세포 거부 반응을 억제하는 면역억제제를 투여하는 단계를 추가로 포함하는 방법.
- 제23항에 있어서, 상기 (e) 단계가 시클로스포린, 미오페닐레이트 모페틸, 라파마이신, 안티-티모사이트 글로불린, 및 환자의 B-세포 및 T-세포의 공동자극을 감소시키는 제제로 이루어진 군으로부터 선택된 면역억제제를 투여하는 것을 포함하는 방법.
- 제1항에 있어서,(e) 세포 분화 인자를 환자에게 투여하여 환자에게 투여될 때 줄기 세포의 분화를 특이화하는 단계를 추가로 포함하는 방법.
- 제1항에 있어서, 상기 (c) 단계가 적어도 일부분의 지방 조직을 부분적으로만 해체시키는 것을 포함하는 방법.
- 제1항에 있어서, 상기 (c) 단계가 지방 조직을 다수의 부분의 지방 조직으로 처리하는 것을 포함하는 방법.
- 제27항에 있어서, 상기 (c) 단계가 다수의 부분의 지방 조직 중 하나 이상을 부분적으로만 해체시키는 것을 포함하는 방법.
- 제27항에 있어서, 상기 지방 조직의 부분 중 둘 이상을 함께 혼합시키는 것을 포함하는 방법.
- 제27항에 있어서, 상기 지방 조직의 부분 중 하나 이상을 처리하여 줄기 세포를 함유하는 펠렛을 형성시키는 방법.
- 제1항에 있어서, 상기 (d) 단계가 지방 조직을 수거한 환자에게 줄기 세포를 투여하는 것을 포함하는 방법.
- 제1항에 있어서,(e) 지방 조직으로부터 수득한 줄기 세포를 냉각시키는 단계를 추가로 포함하는 방법.
- 제1항에 있어서,(e) 지방 조직으로부터 수득한 줄기 세포 부분을 조직 수거 시스템으로부터 수거하는 단계; 및(f) 조직 수거 시스템으로부터 수거된 줄기 세포 부분을 보존하는 단계를 추가로 포함하는 방법.
- 제33항에 있어서, 상기 (f) 단계가 시스템으로부터 수거된 줄기 세포의 부분을 동결보존하는 것을 포함하는 방법.
- 제1항에 있어서, 질병을 치료하기 위해 상기 줄기 세포를 환자에게 투여하는 방법.
- 제1항에 있어서, 환자의 미용적 용모를 치료하기 위해 상기 줄기 세포를 환자에게 투여하는 방법.
- 제1항에 있어서, 골-관련 장애, 질병, 또는 손상, 지방 관련 장애 또는 질병; 간 관련 질병, 장애, 또는 손상, 심근 경색, 신 질병 또는 신장 상해; 망막 질병 또는 상해 또는 괴사; 상처 치유; 골격근 장애 연골 및 관절 모두의 회복; 폐 손상; 당뇨병; 장 장애; 및 신경계 장애, 질병 또는 손상을 치료하기 위하여 상기줄기 세포를 환자에게 투여하는 방법.
- 제1항에 있어서, 상기 (b) 및 (c) 단계가 자동화되는 방법.
- 제1항에 있어서,(e) 줄기 세포를 환자에게 투여한 후 체액과 접촉했던 조직 수거 시스템 부분을 폐기하는 것을 추가로 포함하는 방법.
- (a) (i) 환자로부터 수거된 지방 조직을 수용하도록 구조화된 조직 수집 유입 포트; 및(ii) 용기 내에 배치되고 환자로부터 수거된 지방 조직은 보유하고 환자로부터 수거된 비-지방 조직은 통과시키도록 구조화된 필터를 포함하는 조직 수집 용기;(b) 조직 수거 시스템으로부터 줄기 세포를 수거하지 않은 채로 지방 조직으로부터 수득한 줄기 세포를 수용하도록 조직 수집 용기에 연결되고, 거기에 함유된 줄기 세포와 혼합하기 위한 하나 이상의 첨가제의 투여를 위한 추가 포트를 포함하는 혼합 용기; 및(c) 환자에게 투여하기 위해 혼합 용기 중의 줄기 세포가 조직 수집 시스템으로부터 수거되도록 구조화된 출구를 포함하는, 환자 치료용 조직 수거 시스템.
- 제40항에 있어서, 상기 조직 수집 유입 포트가 환자로부터 지방 조직을 수거하기 위해 환자에게 삽입된 캐뉼라에 연결된 것인 시스템.
- 제40항에 있어서, 상기 조직 수집 용기가 흡인 장치에 연결되도록 구조화된 흡출(aspiration) 포트를 포함하는 것인 시스템.
- 제40항에 있어서, 줄기 세포가 혼합 용기를 통과하기 전에 조직 수집 용기로부터 세포 수집 용기로 통과하도록 조직 수집 용기와 혼합 용기 사이에 배치된 세포 수집 용기를 추가로 포함하는 시스템.
- 제43항에 있어서, 상기 세포 수집 용기가 현탁액의 유체로부터 현탁액 중의 줄기 세포의 분리를 용이하게 하기 위한 세포 농축기를 포함하는 것인 시스템.
- 제43항에 있어서, 상기 세포 수집 용기가 스피닝 막 필터를 포함하는 것인 시스템.
- 제43항에 있어서, 상기 세포 수집 용기가 가요성 백을 포함하는 것인 스템.
- 제43항에 있어서, 세포 수집 용기로부터 혼합 용기로 줄기 세포는 통과시키고, 적어도 거기에 함유된 줄기 세포보다 큰 물질의 통과는 막도록 구조화된 또다른 필터를 추가로 포함하는 시스템.
- 제 47 항에 있어서, 상기 또다른 필터가 직경이 약 200 ㎛ 미만인 다수의 세공을 포함하는 시스템.
- 제 47 항에 있어서, 상기 또다른 필터가 약 20 ㎛ 내지 200 ㎛의 직경을 갖는 다수의 세공을 포함하는 시스템.
- 제 47 항에 있어서, 상기 또다른 필터가 세포 수집 용기로부터 이격되어 있는 시스템.
- 제 47 항에 있어서, 상기 또다른 필터가 세포 수집 용기의 구성요소인 시스템.
- 제 40 항에 있어서, 조직 수집 용기 중에 보유된 조직을 혼합 용기로 통과시키는, 조직 수집 용기로부터 혼합 용기에 이르는 도관을 제공하는 조직 회복 라인을 추가로 포함하는 시스템.
- 제 40 항에 있어서, 시스템 내의 지방 조직의 수거 및 처리를 자동화하도록구조화된 처리 장치를 추가로 포함하는 시스템.
- 제 40 항에 있어서, 흡인 장치에 의해 용기에 흡인을 가할 때 상기 조직 수집 용기가 형태를 유지하는 본체(body)를 포함하는 시스템.
- 제 54 항에 있어서, 상기 조직 수집 용기가 강성의 본체를 포함하는 시스템.
- 제 54 항에 있어서, 상기 조직 수집 용기가 가요성 백을 포함하는 시스템.
- 제 40 항에 있어서, 상기 제 1 필터가 크기가 약 20 ㎛ 내지 5 mm 범위인 다수의 세공을 포함하는 시스템.
- 제 40 항에 있어서, 조직 수집 용기 중에 함유된 물질의 온도를 조정하는 온도 제어 장치를 추가로 포함하는 시스템.
- 제 58 항에 있어서, 상기 온도 제어 장치가 히터인 시스템.
- 제 58 항에 있어서, 조직 수집 용기로 전달되는 유체의 온도를 조정하는 온도 제어 장치가 위치해 있는 시스템.
- 제 40 항에 있어서, 상기 출구가 혼합 용기의 구성요소인 시스템.
- 제 40 항에 있어서, 상기 출구가 혼합 용기로부터 이격되어 있는 시스템.
- 제 40 항에 있어서, 상기 출구가 유체 불투과성 막을 포함하는 시스템.
- 제 40 항에 있어서, 상기 조직 수집 용기, 혼합 용기 및 출구가 외부 환경에 개방되지 않는 밀폐 시스템을 정하는 것인 시스템.
- 제 40 항에 있어서, 출구와 연결되어 혼합 용기 중에 함유된 줄기 세포를 환자에게 전달하는 조직 투여 장치를 추가로 포함하는 시스템.
- 제 40 항에 있어서, 체액과 접촉했던 조직 수거 시스템 부분들을 1 회 사용 후 폐기하도록 구조화된 시스템.
- a) 소정의 줄기 세포 농도를 갖는 지방 조직의 제 1 부분;b) 지방 조직의 제1 부분보다 높은 줄기 세포의 농도를 갖는 지방 조직의 제 2 부분을 포함하는 환자 투여용 조성물.
- 제 67 항에 있어서, 상기 제 1 부분 및 제 2 부분이 함께 혼합된 조성물.
- 제 68 항에 있어서, 상기 지방 조직의 제 2 부분이 실질적으로 성숙한 지방 세포 및 결합 조직이 없는 줄기 세포를 포함하는 조성물.
- 제 69 항에 있어서, 상기 제 2 부분 중의 줄기 세포의 양이 제 2 부분에 존재하는 세포 총량의 약 0.1 %를 초과하는 조성물.
- 제 70 항에 있어서, 상기 제 2 부분 중의 줄기 세포의 양이 제 2 부분 중의 세포 총량의 약 0.1% 내지 약 100%인 조성물.
- 제 70 항에 있어서, 상기 제 2 부분 중의 줄기 세포의 양이 제 2 부분 중의 세포 총량의 약 20%를 초과하는 조성물.
- 제 69 항에 있어서, 상기 혼합 부분의 줄기 세포 농도가 제 1 부분의 줄기 세포의 농도보다 50 % 이상 높은 조성물.
- 제 69 항에 있어서, 상기 혼합 부분의 줄기 세포 농도가 제 1 부분의 줄기 세포의 농도보다 2 배 이상 높은 조성물.
- 제 69 항에 있어서, 상기 혼합 부분의 줄기 세포 농도가 제 1 부분의 줄기 세포의 농도보다 3 배 이상 높은 조성물.
- 제 67 항에 있어서, 줄기 세포의 분화를 제어하도록 하는 양으로 존재하는 세포 분화 인자를 추가로 포함하는 조성물.
- 제 67 항에 있어서, 상기 제 2 부분이 적어도 부분적으로 분해된 (dissociated) 지방 조직을 포함하는 조성물.
- 제 67 항에 있어서, 상기 지방 조직의 제 2 부분이 2 개 이상의 별개의 부분들로 된 지방 조직 배합물을 포함하는 조성물.
- 제 67 항에 있어서, 상기 지방 조직의 제 2 부분이 배양 또는 동결보존 이외의 방법으로 처리된 것인 조성물.
- a) 지방 조직 수거 시스템을 제공하는 단계;b) 지방 조직 수거 시스템을 사용하여 환자로부터 소정 농도의 줄기 세포를 갖는 지방 조직을 수거하는 단계; 및c) 지방 조직 중의 줄기 세포의 농도가 증가하도록 지방 조직을 처리하는 단계;d) 농축된 줄기 세포를 갖는 지방 조직을 또다른 부분의 지방 조직과 혼합하는 단계; 및e) 줄기 세포의 농도가 증가된 지방 조직을 환자에게 투여하는 단계를 포함하는 환자 치료 방법.
- 제 80 항에 있어서, 상기 (b) 단계가 환자로부터 흡출한 지방 조직 및 환자로부터 절제한 지방 조직 중 하나 이상을 포함하는 방법.
- 제 81 항에 있어서, 상기 (c) 단계가 여과된 지방 조직을 해체시킨 후, 스피닝 막 필터를 사용하는 것을 추가로 포함하는 방법.
- 제 80 항에 있어서, 상기 (c) 단계가 지방 조직을 부분들로 나누고, 지방 조직 중 하나 이상의 부분에서 줄기 세포의 농도를 증가시키는 것을 포함하는 방법.
- 제 83 항에 있어서, 상기 지방 조직 중 하나 이상의 부분을 부분적으로만 해체시키는 것을 포함하는 방법.
- 제 83 항에 있어서, 상기 (c) 단계가 줄기 세포의 농도가 증가된 지방 조직 중 하나 이상의 부분과 줄기 세포의 농도가 증가되지 않은 지방 조직 부분을 혼합하는 단계를 추가로 포함하는 방법.
- 제 85 항에 있어서, 상기 줄기 세포의 농도가 증가된 상기 지방 조직 중 하나 이상의 부분을 동결보존된 조직으로부터 수득하는 방법.
- 제 80 항에 있어서, 상기 조직 수거 시스템이 밀폐 시스템이고, (c) 단계가 전적으로 밀폐 시스템 중에서 수행되는 것인 방법.
- 제 80 항에 있어서, 상기 (b) 및 (c) 단계가 자동화되는 방법.
- 제 88 항에 있어서, 상기 (b), (c), 및 (d) 단계가 자동화되는 방법.
- 제 80 항에 있어서, 상기 적어도 일부분의 지방 조직의 부피와 상기 다른 일부분의 지방 조직의 부피의 차이가 25%보다 큰 방법.
- 제 80 항에 있어서, 상기 적어도 일부분의 지방 조직의 부피와 상기 다른 일부분의 지방 조직의 부피의 차이가 100%보다 큰 방법.
- 제 80 항에 있어서, (f) 줄기 세포를 환자에게 투여한 후 체액과 접촉했던 조직 수거 시스템 부분을 폐기하는 단계를 추가로 포함하는 방법.
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