JP5883553B2 - 処理済み脂肪吸引細胞で患者を治療するためのシステムと方法 - Google Patents
処理済み脂肪吸引細胞で患者を治療するためのシステムと方法 Download PDFInfo
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Description
この出願は、2001年12月7日に提出した表題“処理済み脂肪吸引細胞と脂肪由来幹細胞のベッドサイド装置、システム及び使用”の米国仮出願第60/338,856号(参照によってそのすべての内容が本明細書に取り込まれる)の利益を主張する。
(発明の背景)
1.発明の分野
この発明は、一般的に脂肪組識由来の細胞に関し、さらに詳細には、脂肪由来幹細胞、脂肪由来幹細胞の使用方法、脂肪由来幹細胞を含有する組成物、並びに脂肪由来幹細胞を調製及び使用するためのシステムに関する。
再生医療は、正常な治癒機構の一部ではない仕方で、或いは正常な機構を人工的に増強することで体の再生機構を使用する、臨床的に目標とした様式で体の再生機構を利用することとして定義することができる。このプロセスの1つの規範となる例は、骨髄移植に見られ、造血幹細胞と前駆細胞をドナーから収集し、正常な造血再生機構が除去され、或いは実質的に欠失又は損なっているレシピエント中に置くことによって、レシピエントの造血能力を元に戻し又は再生する(Thomas 1994)。最近の臨床又は前臨床研究では、このアプローチは骨(Connolly 1998:Horwitz, Prockopら 1999;Horwitz, Prockopら 2001)、心臓(Fukuda 2001;Orlic, Kajsturaら 2001;Orlic, Kajsturaら 2001;Struer, Brehmら 2002)、及び肝臓(Avital, Inderbitzinら 2001)を含む組織を再生する(又は再生を試みる)研究によって、骨髄の非造血幹細胞成分に拡張されてきた。これら研究は、骨髄内における非造血幹細胞及び内皮前駆細胞の存在の検出に基づいている(Prockop, Aziziら 2000)(Pittenger, Mackayら 1999)(Shi, Rafiiら 1998;Carmeliet及びLuttun 2001)。
本発明は、治療的、構造的、又は美容的な利益を高め、生じさせ、又は維持するのに必要な添加剤と共にレシピエント内に直接置かれる脂肪組織から誘導される細胞を使用するための組成物、方法、及びシステムに関する。
本明細書で述べるいずれの特徴又は特徴の組合せも、いずれの該組合せに含まれる特徴が、文脈、この明細書、及び本技術の当業者の知識から明かなように相互に矛盾しないことを条件として本発明の範囲内に包含される。本発明のさらなる利点及び局面は、以下の詳細な説明で明らかになる。
以下、実施例が添付図面に示されている本発明の現在好ましい実施形態について詳細に言及する。可能な限り、同一又は同等の部分を言及するため図面と説明で同一又は同様の参照番号を使用する。図面は単純化した形態であり、正確な寸法でないことに留意すべきである。本明細書の開示に関しては、便宜と明瞭さだけの目的で、頂、底、左、右、上へ(up)、下へ(down)、上方(over)、上に(above)、下に(below)、下に(beneath)、後ろ(rear)及び前(front)のような方向を示す用語が添付図面について用いられる。このような方向を示す用語は、いかなる様式でも本発明の範囲を限定するものと解釈すべきでない。
本明細書で使用する場合、“脂肪組織の単位”は、脂肪組織の分離した或いは測定できる量を意味する。1単位の脂肪組織は、該単位の重量及び/又は体積を決定することで測定することができる。上で同定したデータに基づき、患者から除去したような1単位の処理済み脂肪吸引物は、少なくとも0.1%の細胞成分が幹細胞である細胞成分を有する。本明細書の開示に関しては、1単位の脂肪組織は患者から除去した脂肪組織の全量、又は患者から除去した脂肪組織の全量より少ない量を指す。従って、1単位の脂肪組織は、別単位の脂肪組織と組み合わせて、個々の単位の合計である重量又は体積を有する脂肪組織の単位を形成することができる。
本明細書で使用する場合、“幹細胞”は、1つ以上の特有機能を果たし、かつ自己複製能力を有する種々の他の細胞型に分化する可能性を有する多能性細胞を意味する。本明細書で開示される幹細胞のいくらかは多分化能性でありうる。
本明細書で使用する場合、“処理済み脂肪吸引物(processed lipoaspirate)”(PLA)は、成熟脂肪細胞と結合組織から活性細胞成分(例えば、幹細胞を含有する成分)を分離するために処理した脂肪組織を意味する。典型的に、PLAは、脂肪組織由来の細胞を洗浄かつ分離して得られる細胞ペレットを指す。ペレットは、典型的に、遠心容器の底に細胞が凝集するように、細胞の懸濁液を遠心分離機にかけることによって得る。
患者から除去した脂肪組織は、さらなる処理のために装置内に集められる。本明細書で論じるように、また一実施形態では、装置は、幹細胞及び/又は内皮前駆細胞を含む、処理した脂肪組織細胞集団の製造用組織を収集する目的のために設計され、かつその目的専用である。他の実施形態では、装置は抽出措置を行う医者によって組織収集用に典型的に使用されるいずれの従来型装置でもよい。
一実施形態では、例えば、米国特許第5,034,135号及び第5,234,608号に開示されているシステムのような連続流れスピニング膜システムなどを介して細胞集団を通過させて、細胞を濃縮し、コラゲナーゼを除去する。
上述の方法に加え、活性細胞集団をさらに精製するために適用できる多くの後洗浄法がある。これらの方法としては、ポジティブ選択(標的細胞を選択する)、ネガティブ選択(不要細胞の選択的除去)、又はその組合せが挙げられる。
抗体媒介ポジティブ選択実施形態は、細胞の固相支持体からの脱着を促す第3添加剤を含めることによって、ほとんど同様に達成できる。この実施形態では、酵素パパイン又はシモパパインを添加して抗体分子を切断し、かつ固相支持体から細胞を離すことができる(Civin, C.I.ら, ポジティブ幹細胞選択基礎科学, Prog Clin Biol Res, 1990. 333(38):p.387-401;考察402)。別の代替は、Tseng Lawら,米国特許第6,017,719号に記載されているような、抗体に対する結合性について細胞表面抗原と競合する特異的ペプチドの使用である。
しわの低減、器官量の増強などを含む物理的特徴を増強又は改良することによってのような美容目的で患者に幹細胞を投与することもできる。
この装置内の処理への一般的アプローチは、手動の細胞処理についてのこの開示の他の箇所で述べたのと同一パラメーターを使用するだろう。
;Hanada, K., J.E. Dannis,及びA.I. Caplan, ラット骨髄由来の間充織幹細胞の骨原性分化に及ぼす塩基性線維芽細胞成長因子及び骨形態形成タンパク質-2の刺激効果,J Bone Miner Res., 1997. 12(10):p.1606-14;Lieberman, J.R.ら, BMP-2-産生マウス間質性細胞系による局所遺伝子療法はげっ歯類の異所性及び同所性骨形成を誘発する,J Orthop Res., 1998. 16(3):p.330-9)、細胞と他の構造成分(例えば、骨断片(Jean, J.L., S.J. Wang,及びM.K. Au, 同種移植片及び自生骨髄移植片による大区分骨欠陥の治療,J Formos Med Assoc, 1997. 96(7):p.553-7)、コラーゲン(Saadeh, P.B.ら, 同種I型コラーゲンによるラット下顎骨の臨界サイズ欠陥の修復,J Craniofac Surg, 2001. 12(6):p.573-579)及び/又はレシピエント内に細胞と共に移植することを意図した合成成分(Petite, H.ら, 組織操作骨再生, Nat Biotechnol, 2000. 18(9):p.859-63.
taf/dynapage.taf?file=/ncb/biotech/v18/n9/full/nbt0900_959.html
taf/dynapage.taf?file=/ncb/biotech/v18/n9/abs/nbt0900_959.html;Gao, J.ら,ラット骨髄由来の間充織幹細胞による骨軟骨性複合移植片の組織操作製作, Tissue Eng, 2001. 7(4):p.363-71;Ohgushi, H.及びA.I. Caplan, 幹細胞技術とバイオセラミックス:細胞から遺伝子操作,J Biomed Mater Res, 1999. 48(6):p.913-27;Caplan, A.I.及びV.M. Goldberg, 骨格組織の組織操作再生の原理,Clin Orthop, 1999(367 Suppl):p.S12-6)との混合を含む細胞のさらなる操作を可能にする追加成分を添加することができる。後処理操作は、細胞培養(Caplan, A.I.及びS.P. Bruder,間充織幹細胞:21世紀の分子医学用基礎単位,Trends Mol Med, 2001. 7(6):p.259-64;Petite,既出;Zuk, P.A.ら,ヒト脂肪組織由来の多血統細胞:細胞を基礎とした療法の含意)、遺伝子伝達(Luskey, B.D.ら, マウス造血幹細胞及び骨髄間質細胞中への遺伝子伝達,Ann N Y Acad Sci, 1990. 612(398):p.398-406;Grompe, M.ら, 遺伝性I型チロシン血症のマウスモデルでの治療試験:進行レポート,J Inherit Metab Dis、1998. 21(5):p.518-31;Gazit, D.ら,操作した多分化能性間充織細胞は骨の再生で統合かつ分化する:新規な細胞媒介遺伝子療法,J Gene Med, 1999. 1(2):p.121-33;Mosca, J.D.ら,遺伝子送達用媒体としての間充織幹細胞,2000(379 Suppl):p.S71-90)、又はさらなる細胞精製(Greenberg, A.W.及びD.A. Hammer,差次的回転付着によって媒介される細胞分離,Biotechnol Bioeng, 2001. 73(2):p.111-24;Mainwaring, G.及びA.F. Rowley, 密度勾配遠心分離及びカバーガラスへの差次的付着を用いた小型サメ(Scyliorhinus canicula)の白血球の分離,Cell Tissue Res, 1985. 241(2):p.283-90;Schweitzer, C.M.ら,ヒト骨髄内皮細胞の単離と培養,Exp Hematol, 1995. 23(1):p.41-8)を含む。このような機能を実行するための機構は、図4に示される装置内に組み込むことができ、或いは別個の装置内に組み込んでもよい。
以下の実施例は、この技術を適用しうる特定の状況及びセッティングを示すために提供されたものであり、本発明及びこの開示に包含される特許請求の範囲を制限することを意図していない。
自家脂肪転移は、同一個体内のある位置から脂肪組織を収集し、別の位置に再移植することを含む比較的普通の美容及び構造的措置である(Coleman, S.R.(1995),“脂肪移植片の長期生存:対照つき実証”, Aesthetic Plast Surg 19(5):421-5;Coleman, S.R.(2001),“構造的脂肪移植片:理想のフィラー?”Clin Plast Surg 28(1):111-9;Coleman, W.P.,3版(1991),“自家脂肪移植”,Plast Reconstr Surg 88(4):736)。しかし、上述したように、この措置は、移植した物質が全体的又は部分的に再吸収され、或いは瘢痕組織によって置換されるといった矛盾する移植によって損なわれることが多い(Eremia, S.及びN. Newman(2000),“自家脂肪移植後の長期追跡検査:最少2回治療の最後の治療を受けて少なくとも12カ月後の116人の患者の結果の分析”, Dermatol Surg 26(12):1150-8)。新しい血管が生成して移植片を養うのにかかる時間中、機能の損失の少なくとも一部は、移植した脂肪組織の壊死に起因しうる。従って、筋肉基盤のような高度に血管性の領域内に移植した組織は、あまりよく潅流されない組織内に移植した場合より良い移植を示す(Guerrerosantos, J., A. Gonzalez-Mendozaら(1996),“筋肉内の遊離脂肪移植片の長期生存:ラットでの実験的研究”, Aesthetic Plast Surg 20(5):403-8)。
この技術の臨床適用では、この開示によって誘導される処理済み脂肪吸引物を調製し、上記開示どおりの無傷(非脱凝集)脂肪組織断片と混合する。脂肪組織と幹細胞の混合物を含む組成物は、輪郭欠陥の補正用の自家軟組織フィラーを供給するため(しわ、“ディヴォット(divots)”、あばた、及び大きい欠損)(Coleman,S.R.(2001),“構造的脂肪移植片:理想のフィラー?”,Clin Plast Surg 28(1):111-9)、又は尿道のような損傷構造に支持体を供給するため(Palma, P.C., C. L. Riccettoら(1997),“圧迫尿失禁のための反復脂肪注入”, J Endourol 11(1):67-70;Lee, P.E., R. C. Kungら(2001).“女性の圧迫尿失禁の治療としての尿道周囲自家脂肪注入:ランダム化二重盲検対照つき試験”, J Urol 165(1):153-8)レシピエント内に移植することができる。
アリルアルコールによる腹腔内注射によって誘発された肝臓障害は、門脈周囲の急性肝臓損傷の一般モデルである(Lee, J. H., Z. Ilicら(1996),“マウスにおけるアリルアルコール誘発肝臓壊死後の修復の細胞キネティクス”, Int J Exp Pathol 77(2):63-72;Werlich, T., K. J. Stillerら(1999),“肝臓再生の幹細胞概念に関する実験的研究II”, Exp Toxicol Pathol 51(1):93-8;Yin, L., D. Lynchら(1999),“アリルアルコールによって誘発された門脈周囲損傷に対するラット肝臓の復旧反応における異なる細胞型の関与”, J Hepatol 31(3):497-507)。このモデルは、肝臓再生に重大な意味をもつ幹細胞集団の存在を実証するために使用されてきた(Yavorkovsky, L., E. Laiら(1995),“アリルアルコールによって誘発された門脈周囲壊死に対するラット肝臓の復旧反応における小さい門脈内幹細胞の関与”,Hepatology 21(6):1702-12;Werlich, T., K. J. Stillerら(1999),“肝臓再生の幹細胞概念に関する実験的研究II”,Exp Toxicol Pathol 51(1):93-8)。我々は、Swiss Websterマウスのこのモデルを改変し、アルコール誘発損傷後処理済み脂肪吸引物を注入した。動物を1週間で犠牲にし、肝臓を除去し、秤量し、かつ組織学検査用に調製した。結果(図6及び7)は、処理済み脂肪吸引物を受けた当該動物における肝臓重量が実質的に向上したことを示す。組織学分析は、白血球浸潤物又は肝臓の重量を異常に増やしうる他のいずれの機構の証拠もない、処理動物内の正常な組織構造を示した。
臨床セッティングでは、肝臓損傷のある患者は、この開示に従って抽出かつ処理した脂肪組織を有する。そして、処理済み脂肪吸引物を全身送達のため静脈内注射し、或いは肝循環系を通じて肝臓を標的にすることができる。
急性心筋梗塞(心臓発作)は心筋に対する虚血性損傷という結果になる。損傷した組織の再潅流及び心筋組織の再生によって組織損傷を最小にすることができる(Murry, C. E., R. W. Wisemanら(1996),“心筋壊死の修復のための骨格筋芽細胞移植術”, J Clin Invest 98(11):2512-23;Orlic, D., J. Kajsturaら(2001),“骨髄細胞は閉塞した心筋を再生する”, Nature 410(6829):701-5;Rajnoch, C.、J. C. Chachquesら(2001),“細胞療法は心筋機能障害を逆転させる”, J Thorac Cardiovasc Surg 121(5):871-8;Struer, B. E., M. Brehmら(2002),“ヒトの閉塞した心筋の自家冠内単核骨髄細胞移植による修復”, Circulation 106(15):1913-8)。この開示で述べたベッドサイドアプローチは、骨髄収集に付随する病的状態なしで、より多くの数と高純度の細胞を供給できるという点で、再生細胞の潜在的に優れた起源を供給するだろう。
Horwitzらは、骨髄由来の幹細胞が、非造血性障害、特に骨形成不全症の患者に対して臨床的利益を提供できることを実証した(Horwitz, E. M., D. J. Prockopら(1999),“骨形成不全症の子供における骨髄由来間充織細胞の移植可能性及び治療効果”, Nat Med 5(3):309-13;Horwitz, E. M., D. J. Prockopら(2001),“重篤な骨形成不全症の子供の骨髄移植に対する臨床反応”Blood 97(5):1227-31)。これら研究では、著者は、培養内で細胞を成長させてMSC成分を膨張させて精製することによって、骨髄内の非造血性幹細胞の低い数と頻度を補うことを試みた。しかし、上述したように、培養内で細胞を成長させることは実質的な技術的及び臨床的な問題を伴い、かつこの開示に従って処理した脂肪組織の、細胞培養を必要とせずに多数の幹細胞の起源を供給する可能性は患者ケアにおける強力な現実的改善を意味する。血縁でないドナーの使用はこの発明の範囲内であるが、このモデルでは、遺伝病(正常な遺伝子型又は無症候性保有者)によって影響を受けない適切に調和したドナー、好ましくは兄弟又は他の第1度の親類が、ドナー細胞の起源である。妥協した組織機能又は再生をもたらす遺伝病の患者内に注入するため細胞を脂肪組織から抽出する。例としては、限定するものではないが、骨形成不全症、デュシュネ筋ジストロフィー(及び他の筋ジストロフィー)、遺伝性網膜変性疾患、遺伝性チロシン血症、及び多くの遺伝病が挙げられる。
本明細書では、多くの出版物及び特許を引用した。引用した出版物及び特許はそれぞれその全体が参照によって本明細書に取り込まれる。
Claims (18)
- 軟組織フィラーの製造方法であって、以下の工程:
脂肪由来幹細胞を含む脱凝集された脂肪吸引物を供給する工程;
非脱凝集脂肪組織断片を供給する工程;及び
前記脱凝集された脂肪吸引物を前記非脱凝集脂肪組織断片と混合して前記軟組織フィラーを得る工程
を含む製造方法。 - 脂肪組織を懸濁液中で酵素的に脱凝集させ、成熟脂肪細胞の存在を減らすことによって、前記脱凝集された脂肪吸引物が得られる、
請求項1に記載の製造方法。 - 遠心分離によって懸濁液中の細胞を分離する工程をさらに含む、請求項2に記載の製造方法。
- 添加剤を供給する工程をさらに含む、請求項1〜3のいずれか1項に記載の製造方法。
- 前記軟組織フィラーが輪郭欠陥の補正に適している、請求項1〜4のいずれか1項に記載の製造方法。
- 前記輪郭欠陥がしわ、ディヴォット、あばた、又は大きい欠損である、請求項5に記載の製造方法。
- 前記軟組織フィラーが損傷構造に支持体を供給するのに適している、請求項1〜4のいずれか1項に記載の製造方法。
- 前記損傷構造が尿道である、請求項7に記載の製造方法。
- 脂肪由来幹細胞を含む脱凝集された脂肪吸引物が凍結保存されたものである、請求項1〜8のいずれか1項に記載の製造方法。
- 脂肪組織移植片の製造方法であって、以下の工程:
脂肪組織の第1部分を供給する工程;
脂肪細胞の前記第1部分を酵素的に脱凝集させて脱凝集細胞懸濁液を製造する工程;
前記脱凝集細胞懸濁液中の成熟脂肪細胞の存在を減らす工程;
脂肪由来幹細胞を含む細胞集団から前記脱凝集細胞懸濁液中の無細胞成分の一部を分離することによって脂肪由来幹細胞を含む前記細胞集団を濃縮する工程;
脂肪組織の第2部分を供給する工程;及び
脂肪由来幹細胞を含む前記濃縮細胞集団を脂肪組織の前記第2部分と混合して前記脂肪組織移植片を得る工程
を含む製造方法。 - 前記酵素的脱凝集がコラゲナーゼの使用を含む、請求項10に記載の製造方法。
- 前記細胞集団が遠心分離によって濃縮される、請求項10に記載の製造方法。
- 添加剤を供給する工程をさらに含む、請求項10〜12のいずれか1項に記載の製造方法。
- 前記脂肪組織移植片が輪郭欠陥の補正に適している、請求項10〜13のいずれか1項に記載の方法。
- 前記輪郭欠陥がしわ、ディヴォット、あばた、又は大きい欠損である、請求項14に記載の製造方法。
- 前記脂肪組織移植片が損傷構造に支持体を供給するのに適している、請求項10〜13のいずれか1項に記載の製造方法。
- 前記損傷構造が尿道である、請求項16に記載の製造方法。
- 脂肪由来幹細胞を含む前記濃縮細胞集団が凍結保存されたものである、請求項10〜17のいずれか1項に記載の製造方法。
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Families Citing this family (352)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7595043B2 (en) * | 2001-12-07 | 2009-09-29 | Cytori Therapeutics, Inc. | Method for processing and using adipose-derived stem cells |
US9597395B2 (en) | 2001-12-07 | 2017-03-21 | Cytori Therapeutics, Inc. | Methods of using adipose tissue-derived cells in the treatment of cardiovascular conditions |
US20060204556A1 (en) * | 2001-12-07 | 2006-09-14 | Cytori Therapeutics, Inc. | Cell-loaded prostheses for regenerative intraluminal applications |
US7585670B2 (en) * | 2001-12-07 | 2009-09-08 | Cytori Therapeutics, Inc. | Automated methods for isolating and using clinically safe adipose derived regenerative cells |
US7771716B2 (en) * | 2001-12-07 | 2010-08-10 | Cytori Therapeutics, Inc. | Methods of using regenerative cells in the treatment of musculoskeletal disorders |
US20050095228A1 (en) | 2001-12-07 | 2005-05-05 | Fraser John K. | Methods of using regenerative cells in the treatment of peripheral vascular disease and related disorders |
JP4653952B2 (ja) | 2001-12-07 | 2011-03-16 | サイトリ セラピューティクス インコーポレイテッド | 処理済み脂肪吸引細胞で患者を治療するためのシステムと方法 |
US7514075B2 (en) * | 2001-12-07 | 2009-04-07 | Cytori Therapeutics, Inc. | Systems and methods for separating and concentrating adipose derived stem cells from tissue |
US20050048036A1 (en) * | 2001-12-07 | 2005-03-03 | Hedrick Marc H. | Methods of using regenerative cells in the treatment of inherited and acquired disorders of the bone, bone marrow, liver, and other tissues |
US20050008626A1 (en) * | 2001-12-07 | 2005-01-13 | Fraser John K. | Methods of using adipose tissue-derived cells in the treatment of cardiovascular conditions |
US8404229B2 (en) * | 2001-12-07 | 2013-03-26 | Cytori Therapeutics, Inc. | Methods of using adipose derived stem cells to treat acute tubular necrosis |
US8105580B2 (en) | 2001-12-07 | 2012-01-31 | Cytori Therapeutics, Inc. | Methods of using adipose derived stem cells to promote wound healing |
US7651684B2 (en) | 2001-12-07 | 2010-01-26 | Cytori Therapeutics, Inc. | Methods of using adipose tissue-derived cells in augmenting autologous fat transfer |
AU2003220424A1 (en) * | 2002-03-19 | 2003-10-08 | Advanced Research And Technology Transfer | Adipose stromal stem cells for tissue and vascular modification |
US9144583B2 (en) * | 2002-03-29 | 2015-09-29 | Tissue Genesis, Inc. | Cell separation apparatus and methods of use |
US8202725B2 (en) | 2004-12-23 | 2012-06-19 | Tissue Genesis Incorporated | Cell sodding method and apparatus |
US7179391B2 (en) | 2002-05-24 | 2007-02-20 | Biomet Manufacturing Corp. | Apparatus and method for separating and concentrating fluids containing multiple components |
US7992725B2 (en) * | 2002-05-03 | 2011-08-09 | Biomet Biologics, Llc | Buoy suspension fractionation system |
US20030205538A1 (en) | 2002-05-03 | 2003-11-06 | Randel Dorian | Methods and apparatus for isolating platelets from blood |
US7832566B2 (en) | 2002-05-24 | 2010-11-16 | Biomet Biologics, Llc | Method and apparatus for separating and concentrating a component from a multi-component material including macroparticles |
US7845499B2 (en) | 2002-05-24 | 2010-12-07 | Biomet Biologics, Llc | Apparatus and method for separating and concentrating fluids containing multiple components |
US20060278588A1 (en) | 2002-05-24 | 2006-12-14 | Woodell-May Jennifer E | Apparatus and method for separating and concentrating fluids containing multiple components |
US7160719B2 (en) | 2002-06-07 | 2007-01-09 | Mayo Foundation For Medical Education And Research | Bioartificial liver system |
DK1599575T3 (da) * | 2003-02-20 | 2012-01-16 | Cytori Therapeutics Inc | Fremgangsmåder til anvendelse af adipøst vævs-afledte celler i behandlingen af kardiovaskulære tilstande |
US8460243B2 (en) | 2003-06-10 | 2013-06-11 | Abbott Diabetes Care Inc. | Glucose measuring module and insulin pump combination |
JP4722041B2 (ja) * | 2003-06-18 | 2011-07-13 | サイトリ セラピューティクス インコーポレイテッド | オートロガス脂肪導入増進における、脂肪組織由来細胞の使用方法 |
US20050026275A1 (en) * | 2003-06-23 | 2005-02-03 | Andrej Bahoric | Device, system and method for receiving, processing and dispersing cells |
WO2005012480A2 (en) * | 2003-06-25 | 2005-02-10 | Macropore Biosurgery Inc. | Systems and methods for separating and concentrating regenerative cells from tissue |
US7722536B2 (en) | 2003-07-15 | 2010-05-25 | Abbott Diabetes Care Inc. | Glucose measuring device integrated into a holster for a personal area network device |
US7172579B2 (en) * | 2003-09-09 | 2007-02-06 | Civco Medical Instruments Co., Inc. | System and method for irrigation and tissue evacuation and collection |
EP1670315B1 (en) * | 2003-09-17 | 2017-04-19 | Cytori Therapeutics, Inc. | Methods of using adipose derived regenerative cells in the treatment of peripheral vascular disease |
JP4749331B2 (ja) * | 2003-10-07 | 2011-08-17 | 株式会社バイオマスター | 脂肪由来前駆細胞の細胞分化 |
JP2007508018A (ja) | 2003-10-08 | 2007-04-05 | べト−ステム インコーポレイテッド | 新規の幹細胞組成物の調製法および使用法、ならびにこの組成物を含有するキット |
EP1743021B1 (en) * | 2004-03-19 | 2014-03-26 | Cytori Therapeutics, Inc. | Method of preparing regenerative cells on a cell carrier and cell carrier containment device |
US7588732B2 (en) * | 2004-03-30 | 2009-09-15 | Genesis Biosystems, Inc. | Autologus tissue harvesting and irrigation device |
CA2563518C (en) * | 2004-04-23 | 2014-09-02 | Bioe, Inc. | Multi-lineage progenitor cells |
CA2858901C (en) | 2004-06-04 | 2024-01-16 | Carolyn Anderson | Diabetes care host-client architecture and data management system |
WO2006014158A1 (en) * | 2004-07-01 | 2006-02-09 | Macropore Biosurgery Inc. | Treating disorders by administering regenerative cells. |
CN102204928B (zh) * | 2004-07-01 | 2014-09-17 | 马克罗珀尔生物外科公司 | 再生细胞用于促进伤口愈合的应用 |
ATE478942T1 (de) * | 2004-07-01 | 2010-09-15 | Cytori Therapeutics Inc | Verfahren zur verwendung regenerativer zellen bei der behandlung von nierenkrankheiten und störungen |
CN101031639A (zh) * | 2004-07-01 | 2007-09-05 | 马克罗珀尔生物外科公司 | 使用再生细胞促进伤口愈合的方法 |
EP2980206A1 (en) * | 2004-07-01 | 2016-02-03 | Cytori Therapeutics, Inc. | Methods of using regenerative cells in the treatment of musculoskeletal disorders |
JP4731556B2 (ja) * | 2004-07-02 | 2011-07-27 | サイトリ セラピューティクス インコーポレイテッド | 臨床的に安全な脂肪組織由来再生細胞を単離し、使用するためのシステムおよび方法 |
US8715733B2 (en) * | 2004-07-23 | 2014-05-06 | DePuy Synthes Products, LLC | Enhanced adipose tissue |
US7993578B2 (en) * | 2004-10-29 | 2011-08-09 | Depuy Spine, Inc. | Methods and kits for aseptic filling of products |
WO2006062989A1 (en) * | 2004-12-07 | 2006-06-15 | Bacterin International, Inc. | Three-dimensional cell culsture system |
US8017395B2 (en) * | 2004-12-17 | 2011-09-13 | Lifescan, Inc. | Seeding cells on porous supports |
US9351669B2 (en) | 2009-09-30 | 2016-05-31 | Abbott Diabetes Care Inc. | Interconnect for on-body analyte monitoring device |
EP1830862B1 (en) * | 2004-12-30 | 2012-12-19 | PrimeGen Biotech LLC | Adipose-derived stem cells for tissue regeneration and wound healing |
US20080140451A1 (en) * | 2005-01-10 | 2008-06-12 | Cytori Therapeutics, Inc. | Devices and Methods for Monitoring, Managing, and Servicing Medical Devices |
US7866485B2 (en) | 2005-02-07 | 2011-01-11 | Hanuman, Llc | Apparatus and method for preparing platelet rich plasma and concentrates thereof |
US7708152B2 (en) | 2005-02-07 | 2010-05-04 | Hanuman Llc | Method and apparatus for preparing platelet rich plasma and concentrates thereof |
WO2006086199A1 (en) | 2005-02-07 | 2006-08-17 | Hanuman Llc | Platelet rich plasma concentrate apparatus and method |
US8622997B2 (en) | 2005-03-23 | 2014-01-07 | Ronald D. Shippert | Tissue transfer method and apparatus |
US7794449B2 (en) * | 2005-03-23 | 2010-09-14 | Shippert Ronald D | Tissue transplantation method and apparatus |
US8062286B2 (en) | 2005-03-23 | 2011-11-22 | Shippert Ronald D | Tissue transplantation method and apparatus |
US7789872B2 (en) | 2005-03-23 | 2010-09-07 | Shippert Ronald D | Tissue transplantation method and apparatus |
US7780649B2 (en) | 2005-03-23 | 2010-08-24 | Shippert Ronald D | Tissue transplantation method and apparatus |
US9581942B1 (en) | 2005-03-23 | 2017-02-28 | Shippert Enterprises, Llc | Tissue transfer method and apparatus |
KR100907248B1 (ko) * | 2005-04-21 | 2009-07-10 | (주)안트로젠 | 분화된 어린 지방 세포와 생분해성 중합체의 이식에 의한신체의 부피 대체 방법 |
EP1885382B1 (en) * | 2005-05-25 | 2011-03-02 | Cytori Therapeutics, Inc. | Methods of using adipose tissue-derived cells in the treatment of cardiovascular conditions |
AU2006202209B2 (en) * | 2005-05-27 | 2011-04-14 | Lifescan, Inc. | Amniotic fluid derived cells |
US9074189B2 (en) * | 2005-06-08 | 2015-07-07 | Janssen Biotech, Inc. | Cellular therapy for ocular degeneration |
JP4907908B2 (ja) * | 2005-06-29 | 2012-04-04 | ルネサスエレクトロニクス株式会社 | 駆動回路及び表示装置 |
EP1902128A4 (en) * | 2005-07-12 | 2009-02-25 | Tissue Genesis Inc | APPARATUS AND METHODS FOR PREPARING TISSUE GRAFT |
US7531355B2 (en) * | 2005-07-29 | 2009-05-12 | The Regents Of The University Of California | Methods and compositions for smooth muscle reconstruction |
FR2890976B1 (fr) * | 2005-09-20 | 2007-12-14 | Univ La Reunion | Kit pour preparer une composition comprenant des cellules adipocytaires et procede d'obtention de ladite composition |
KR20070095494A (ko) * | 2005-09-28 | 2007-10-01 | 세원셀론텍(주) | 지방 조직 수복용 반고형성 젤 조성물의 제조방법 |
US7989205B2 (en) * | 2005-10-06 | 2011-08-02 | American Cryostem Corporation | Cell culture media, kits and methods of use |
WO2007046501A1 (ja) | 2005-10-21 | 2007-04-26 | Kaneka Corporation | 幹細胞の分離材および分離方法 |
US20070213718A1 (en) * | 2006-02-14 | 2007-09-13 | Sdgi Holdings, Inc. | Treatment of the vertebral column |
US7520888B2 (en) * | 2006-02-14 | 2009-04-21 | Warsaw Orthopedic, Inc. | Treatment of the vertebral column |
US20070213717A1 (en) * | 2006-02-14 | 2007-09-13 | Sdgi Holdings, Inc. | Biological fusion in the vertebral column |
US20070227547A1 (en) * | 2006-02-14 | 2007-10-04 | Sdgi Holdings, Inc. | Treatment of the vertebral column |
US8016859B2 (en) | 2006-02-17 | 2011-09-13 | Medtronic, Inc. | Dynamic treatment system and method of use |
KR100764640B1 (ko) * | 2006-03-08 | 2007-10-10 | 세원셀론텍(주) | 지방조직 수복용 키트 |
US20070224173A1 (en) * | 2006-03-21 | 2007-09-27 | Koullick Edouard A | Nonexpansion Protocol for Autologous Cell-Based Therapies |
US8741643B2 (en) | 2006-04-28 | 2014-06-03 | Lifescan, Inc. | Differentiation of pluripotent stem cells to definitive endoderm lineage |
US20070258956A1 (en) * | 2006-05-02 | 2007-11-08 | Biomet Manufacturing Corp. | Methods and apparatus for promoting hair growth using adipose cell based therapies |
US8567609B2 (en) | 2006-05-25 | 2013-10-29 | Biomet Biologics, Llc | Apparatus and method for separating and concentrating fluids containing multiple components |
US20090304644A1 (en) * | 2006-05-30 | 2009-12-10 | Cytori Therapeutics, Inc. | Systems and methods for manipulation of regenerative cells separated and concentrated from adipose tissue |
WO2007145442A1 (en) * | 2006-06-14 | 2007-12-21 | Infitron, Inc. | Composition for transplantation comprising adipose stem cells or adipocytes |
CN101473030A (zh) * | 2006-06-15 | 2009-07-01 | Rnl生物技术株式会社 | 含有来自人类脂肪组织的多塑性干细胞、成纤维细胞和脂肪或脂肪细胞的整容或整形组合物 |
WO2008013863A2 (en) * | 2006-07-26 | 2008-01-31 | Cytori Therapeutics, Inc. | Generation of adipose tissue and adipocytes |
US20100092432A1 (en) * | 2006-08-08 | 2010-04-15 | Takenori Ozaki | Cell preparation containing multipotential stem cells originating in fat tissue |
EP2056918B1 (en) * | 2006-08-29 | 2017-08-23 | Tissue Genesis, Inc. | Catheter for cell delivery |
EP1897570A1 (en) * | 2006-09-08 | 2008-03-12 | Gelanus B.V. | Blood recuperation device and method |
CA2964674A1 (en) | 2006-09-28 | 2008-03-28 | Smith & Nephew, Inc. | Portable wound therapy system |
US8968272B2 (en) * | 2006-10-06 | 2015-03-03 | Lipocosm Llc | Closed system and method for atraumatic, low pressure, continuous harvesting, processing, and grafting of lipoaspirate |
CA2668529A1 (en) * | 2006-11-03 | 2008-05-15 | The University Of Utah | Ventricular assist device capable of implantation of stem cells |
US20130324882A1 (en) * | 2012-05-30 | 2013-12-05 | Devicor Medical Products, Inc. | Control for biopsy device |
JP5038336B2 (ja) * | 2007-02-16 | 2012-10-03 | オリンパス株式会社 | 脂肪消化終了判定装置および脂肪組織消化装置 |
US8034014B2 (en) | 2007-03-06 | 2011-10-11 | Biomet Biologics, Llc | Angiogenesis initation and growth |
US9045735B2 (en) * | 2007-04-03 | 2015-06-02 | The Cleveland Clinic Foundation | Enrichment of tissue-derived adult stem cells based on retained extracellular matrix material |
US8328024B2 (en) | 2007-04-12 | 2012-12-11 | Hanuman, Llc | Buoy suspension fractionation system |
EP2146794B1 (en) | 2007-04-12 | 2016-10-19 | Biomet Biologics, LLC | Buoy suspension fractionation system |
US11174458B2 (en) | 2007-04-23 | 2021-11-16 | Koligo Therapeutics, Inc. | Cell separation apparatus and methods of use |
US8574567B2 (en) | 2007-05-03 | 2013-11-05 | The Brigham And Women's Hospital, Inc. | Multipotent stem cells and uses thereof |
EP2155860B1 (en) | 2007-05-03 | 2014-08-27 | The Brigham and Women's Hospital, Inc. | Multipotent stem cells and uses thereof |
ATE487441T1 (de) * | 2007-06-01 | 2010-11-15 | Allergan Inc | Gerät zur erzeugung des zugspannungsinduzierten wachstums von biologischem gewebe |
US9080145B2 (en) | 2007-07-01 | 2015-07-14 | Lifescan Corporation | Single pluripotent stem cell culture |
GB0712763D0 (en) * | 2007-07-02 | 2007-08-08 | Smith & Nephew | Apparatus |
US9408954B2 (en) | 2007-07-02 | 2016-08-09 | Smith & Nephew Plc | Systems and methods for controlling operation of negative pressure wound therapy apparatus |
GB0715259D0 (en) | 2007-08-06 | 2007-09-12 | Smith & Nephew | Canister status determination |
EP2192908A4 (en) * | 2007-07-25 | 2010-09-01 | Bioe Inc | DIFFERENTIATION OF PRECURSOR CELLS OF MULTIPLE ABSTRACTS AGAINST CHONDROCYTES |
EP2610336A1 (en) | 2007-07-31 | 2013-07-03 | Lifescan, Inc. | Differentiation of human embryonic stem cells |
US9062290B2 (en) | 2007-11-27 | 2015-06-23 | Lifescan, Inc. | Differentiation of human embryonic stem cells |
WO2009073724A1 (en) | 2007-12-04 | 2009-06-11 | Ingeneron, Inc. | Apparatus and methods for cell isolation |
US11253399B2 (en) | 2007-12-06 | 2022-02-22 | Smith & Nephew Plc | Wound filling apparatuses and methods |
US20130096518A1 (en) | 2007-12-06 | 2013-04-18 | Smith & Nephew Plc | Wound filling apparatuses and methods |
US20090181104A1 (en) * | 2007-12-14 | 2009-07-16 | Gino Rigotti | Breast reconstruction or augmentation using computer-modeled deposition of processed adipose tissue |
US20090192528A1 (en) * | 2008-01-29 | 2009-07-30 | Biomet Biologics, Inc. | Method and device for hernia repair |
US20090209456A1 (en) * | 2008-02-19 | 2009-08-20 | Iliana Sweis | Compositions and methods for improving facial and body aesthetics |
KR20190057164A (ko) | 2008-02-21 | 2019-05-27 | 얀센 바이오테크 인코포레이티드 | 세포 부착, 배양 및 탈리를 위한 방법, 표면 개질 플레이트 및 조성물 |
GB0803564D0 (en) | 2008-02-27 | 2008-04-02 | Smith & Nephew | Fluid collection |
EP2620139B1 (en) | 2008-02-27 | 2016-07-20 | Biomet Biologics, LLC | Interleukin-1 receptor antagonist rich solutions |
EP2254991B1 (en) | 2008-02-29 | 2018-08-22 | Biomet Manufacturing, LLC | A system and process for separating a material |
AU2009225590B2 (en) | 2008-03-20 | 2013-05-02 | Stephen H. Bartelmez | Enhancing vessel lesion homing and repair potential of stem cells |
US20110008299A1 (en) * | 2008-03-26 | 2011-01-13 | Ams Research Corporation | Treatment of pelvic floor disorders with an adipose-derived cell composition |
CN102083962B (zh) * | 2008-04-30 | 2013-03-27 | 吉诺米克斯股份有限公司 | 生物体内功能性细胞的高效采集方法 |
US8414519B2 (en) | 2008-05-21 | 2013-04-09 | Covidien Lp | Wound therapy system with portable container apparatus |
EP2294187A2 (en) * | 2008-05-21 | 2011-03-16 | BioE LLC | Differentiation of multi-lineage progenitor cells to pancreatic cells |
US10912869B2 (en) | 2008-05-21 | 2021-02-09 | Smith & Nephew, Inc. | Wound therapy system with related methods therefor |
US8012077B2 (en) | 2008-05-23 | 2011-09-06 | Biomet Biologics, Llc | Blood separating device |
JP5015865B2 (ja) * | 2008-06-09 | 2012-08-29 | オリンパス株式会社 | 脂肪組織洗浄装置 |
US9144584B2 (en) * | 2008-06-11 | 2015-09-29 | Cell4Vet Corporation | Adipose tissue-derived stem cells for veterinary use |
CA2729121C (en) | 2008-06-30 | 2019-04-09 | Centocor Ortho Biotech Inc. | Differentiation of pluripotent stem cells |
US20100028307A1 (en) * | 2008-07-31 | 2010-02-04 | O'neil John J | Pluripotent stem cell differentiation |
BRPI0917993B8 (pt) * | 2008-08-14 | 2021-05-25 | Mesoblast Int Sarl | composições de célula-tronco mesenquimal purificada |
WO2010021993A1 (en) * | 2008-08-19 | 2010-02-25 | Cytori Therapeutics, Inc. | Methods of using adipose tissue-derived cells in the treatment of the lymphatic system and malignant disease |
US8827983B2 (en) | 2008-08-21 | 2014-09-09 | Smith & Nephew, Inc. | Sensor with electrical contact protection for use in fluid collection canister and negative pressure wound therapy systems including same |
AU2009201915C1 (en) * | 2008-08-22 | 2015-02-26 | Regeneus Ltd | Therapeutic methods |
AU2011247866B9 (en) * | 2008-08-22 | 2014-02-13 | Regeneus Ltd. | Allogeneic therapeutic methods using adipose tissue-derived cell suspensions |
EP2350274B1 (en) * | 2008-10-21 | 2019-01-23 | The General Hospital Corporation | Cell transplantation |
CA2742268C (en) | 2008-10-31 | 2020-02-18 | Centocor Ortho Biotech Inc. | Differentiation of human embryonic stem cells to the pancreatic endocrine lineage |
MX2011004563A (es) | 2008-10-31 | 2011-06-01 | Centocor Ortho Biotech Inc | Diferenciacion de celulas madre embrionarias humanas al linaje endocrino pancreatico. |
US20100112696A1 (en) * | 2008-11-03 | 2010-05-06 | Baxter International Inc. | Apparatus And Methods For Processing Tissue To Release Cells |
US8865199B2 (en) * | 2008-11-17 | 2014-10-21 | Ingeneron, Inc. | Biomatrix composition and methods of biomatrix seeding |
US9192695B2 (en) | 2008-11-20 | 2015-11-24 | Allosource | Allografts combined with tissue derived stem cells for bone healing |
CA2744227C (en) * | 2008-11-20 | 2018-10-02 | Centocor Ortho Biotech Inc. | Methods and compositions for cell attachment and cultivation on planar substrates |
KR101837080B1 (ko) | 2008-11-20 | 2018-03-09 | 얀센 바이오테크 인코포레이티드 | 마이크로-캐리어 상의 만능 줄기 세포 배양 |
US8309343B2 (en) | 2008-12-01 | 2012-11-13 | Baxter International Inc. | Apparatus and method for processing biological material |
JP2010178830A (ja) * | 2009-02-04 | 2010-08-19 | Olympus Corp | 生体移植材とその製造方法 |
EP2408401B1 (en) | 2009-03-03 | 2016-05-11 | The Trustees of Columbia University in the City of New York | Methods, devices, and systems for bone tissue engineering using a bioreactor |
US8187475B2 (en) | 2009-03-06 | 2012-05-29 | Biomet Biologics, Llc | Method and apparatus for producing autologous thrombin |
WO2010105204A2 (en) | 2009-03-13 | 2010-09-16 | Mayo Foundation For Medical Education And Research | Bioartificial liver |
US8313954B2 (en) | 2009-04-03 | 2012-11-20 | Biomet Biologics, Llc | All-in-one means of separating blood components |
AU2009100401A4 (en) * | 2009-04-30 | 2009-06-04 | Gl Holdings Inc Bv | Method of extracting and activating adipose-derived stem cells |
US8333740B2 (en) * | 2009-05-01 | 2012-12-18 | Shippert Ronald D | Tissue transfer cannula |
KR101644534B1 (ko) * | 2009-05-01 | 2016-08-01 | 비미니 테크놀로지스 엘엘씨 | 조직 및 세포 부유화 이식편의 최적화 시스템, 방법 및 조성물 |
WO2010129775A1 (en) | 2009-05-06 | 2010-11-11 | University Of Virginia Patent Foundation | Self-illuminated handheld lens for retinal examination and photography and related method thereof |
US20100291534A1 (en) * | 2009-05-12 | 2010-11-18 | National Central University | Methods and Systems for Isolating, Ex Vivo Expanding and Harvesting Hematopoietic Stem Cells |
US8100874B1 (en) | 2009-05-22 | 2012-01-24 | Donnell Mark Jordan | Tissue refining device |
US9867788B2 (en) * | 2009-07-09 | 2018-01-16 | Boston Scientific Scimed, Inc. | Multi-chamber cellular mixing and delivery system and method |
US9011800B2 (en) | 2009-07-16 | 2015-04-21 | Biomet Biologics, Llc | Method and apparatus for separating biological materials |
KR102058901B1 (ko) | 2009-07-20 | 2019-12-24 | 얀센 바이오테크 인코포레이티드 | 인간 배아 줄기 세포의 분화 |
GB2485112B (en) * | 2009-07-20 | 2014-02-26 | Janssen Biotech Inc | Differentiation of human embryonic stem cells |
WO2011011349A2 (en) | 2009-07-20 | 2011-01-27 | Centocor Ortho Biotech Inc. | Differentiation of human embryonic stem cells |
US20110213336A1 (en) | 2009-08-05 | 2011-09-01 | Cucin Robert L | Method of and apparatus for sampling, processing and collecting tissue and reinjecting the same into human patients |
US8348929B2 (en) | 2009-08-05 | 2013-01-08 | Rocin Laboratories, Inc. | Endoscopically-guided tissue aspiration system for safely removing fat tissue from a patient |
US8465471B2 (en) | 2009-08-05 | 2013-06-18 | Rocin Laboratories, Inc. | Endoscopically-guided electro-cauterizing power-assisted fat aspiration system for aspirating visceral fat tissue within the abdomen of a patient |
EP2471542B1 (en) * | 2009-08-28 | 2016-04-27 | Osaka Air Machine Service, Ltd. | Therapeutic agent for liver-related diseases |
US20110086426A1 (en) * | 2009-10-13 | 2011-04-14 | Lipostem Corp. | Methods and apparatus for collecting and separating regenerative cells from adipose tissue |
CN102711777B (zh) | 2009-10-28 | 2015-04-15 | 吉诺米克斯股份有限公司 | 利用骨髓间充质干细胞和/或多能干细胞的血中动员的组织再生促进剂 |
CN102058905B (zh) * | 2009-11-18 | 2013-04-24 | 四川大学 | 一种复合脂肪颗粒及其制备方法 |
US20140286911A1 (en) | 2013-03-15 | 2014-09-25 | Allosource | Cell repopulated collagen matrix for soft tissue repair and regeneration |
US20120253317A1 (en) * | 2009-12-18 | 2012-10-04 | Birscet, LLC | Adipose tissue management systems |
SE0951009A1 (sv) | 2009-12-22 | 2011-06-23 | Anordning och förfarande för rening och anrikning av biologiskt prov | |
SG181822A1 (en) | 2009-12-23 | 2012-08-30 | Centocor Ortho Biotech Inc | Differentiation of human embryonic stem cells |
WO2011079017A2 (en) | 2009-12-23 | 2011-06-30 | Centocor Ortho Biotech Inc. | Differentiation of human embryonic stem cells |
AT509071B1 (de) * | 2010-01-29 | 2011-06-15 | Heinrich Karl Georg Ddr | Verfahren zur reinigung mesenchymaler stammzellen |
US10588609B2 (en) * | 2010-02-04 | 2020-03-17 | Procept Biorobotics Corporation | Gene analysis and generation of stem cell methods and apparatus |
EP2542667A4 (en) | 2010-03-01 | 2013-07-31 | Janssen Biotech Inc | PROCESS FOR CLEANING CELLS OBTAINED FROM PLURIPOTENTIAL STEM CELLS |
ITGE20100026A1 (it) * | 2010-03-23 | 2011-09-24 | Carlo Tremolada | Metodo e dispositivo per la preparazione di tessuto, in particolare tessuto adiposo per trapianto ottenuto da materiale adiposo lobulare estratto tramite liposuzione |
US8591391B2 (en) | 2010-04-12 | 2013-11-26 | Biomet Biologics, Llc | Method and apparatus for separating a material |
US8790321B2 (en) | 2010-04-21 | 2014-07-29 | Genesis Medical Devices, LLC | Apparatus, system, and method for harvesting improved bone graft material with reamer-irrigator-aspirator (RIA) device |
KR101903562B1 (ko) | 2010-05-12 | 2018-10-02 | 얀센 바이오테크 인코포레이티드 | 인간 배아 줄기 세포의 분화 |
US9352003B1 (en) | 2010-05-14 | 2016-05-31 | Musculoskeletal Transplant Foundation | Tissue-derived tissuegenic implants, and methods of fabricating and using same |
US8883210B1 (en) | 2010-05-14 | 2014-11-11 | Musculoskeletal Transplant Foundation | Tissue-derived tissuegenic implants, and methods of fabricating and using same |
US10130736B1 (en) | 2010-05-14 | 2018-11-20 | Musculoskeletal Transplant Foundation | Tissue-derived tissuegenic implants, and methods of fabricating and using same |
WO2013106655A1 (en) | 2012-01-11 | 2013-07-18 | The Gid Group, Inc. | Method for processing adipose tissue and processing apparatus |
WO2012006587A2 (en) * | 2010-07-09 | 2012-01-12 | The Gid Group, Inc. | Apparatus and methods relating to collecting and processing human biological material containing adipose |
US9206387B2 (en) | 2010-07-09 | 2015-12-08 | The Gid Group, Inc. | Method and apparatus for processing adipose tissue |
US9296984B2 (en) | 2010-07-09 | 2016-03-29 | The Gid Group, Inc. | Tissue processing apparatus and method for processing adipose tissue |
WO2012019103A2 (en) | 2010-08-06 | 2012-02-09 | The General Hospital Corporation D/B/A | System and apparatus for cell treatment |
US9669200B2 (en) | 2010-08-06 | 2017-06-06 | Boston Scientific Scimed, Inc. | Systems and methods for the treatment of pelvic disorders including magnetic particulates |
EP2611909B1 (en) | 2010-08-31 | 2018-01-17 | Janssen Biotech, Inc. | Differentiation of human embryonic stem cells |
US9181528B2 (en) | 2010-08-31 | 2015-11-10 | Janssen Biotech, Inc. | Differentiation of pluripotent stem cells |
CN103154239B (zh) | 2010-08-31 | 2018-05-15 | 詹森生物科技公司 | 人胚胎干细胞的分化 |
US8936766B2 (en) * | 2010-10-04 | 2015-01-20 | Spinesmith Partners, L.P. | Device and method for delivering mechanically released cells from liposuction aspirates |
WO2012068248A2 (en) * | 2010-11-16 | 2012-05-24 | Ingeneron, Inc. | Methods for preserving target cells |
US9180172B2 (en) | 2010-12-15 | 2015-11-10 | Ams Research Corporation | Treatment of Peyronies disease |
US8979797B2 (en) | 2010-12-16 | 2015-03-17 | Ams Research Corporation | High pressure delivery system and method for treating pelvic disorder using large molecule therapeutics |
CA2823123A1 (en) | 2010-12-27 | 2012-07-05 | Intellicell Biosciences, Inc. | Ultrasonic cavitation derived stromal or mesenchymal vascular extracts and cells derived therefrom obtained from adipose tissue and use thereof |
US10136845B2 (en) | 2011-02-28 | 2018-11-27 | Abbott Diabetes Care Inc. | Devices, systems, and methods associated with analyte monitoring devices and devices incorporating the same |
US8887770B1 (en) | 2011-03-17 | 2014-11-18 | Ronald D. Shippert | Vessel fill control method and apparatus |
CN102151153A (zh) * | 2011-03-25 | 2011-08-17 | 吴成翰 | 外科手术过程中组织碎片的回收装置 |
US8512326B2 (en) | 2011-06-24 | 2013-08-20 | Arqos Surgical, Inc. | Tissue extraction devices and methods |
EP3358011B1 (en) | 2011-04-26 | 2020-03-04 | StemRIM Inc. | Peptide for inducing regeneration of tissue and use thereof |
US10035118B2 (en) * | 2011-04-28 | 2018-07-31 | Spinesmith Partners, L.P. | Lipoaspirate stem cell separation system and methods thereof |
US9109198B2 (en) | 2011-04-29 | 2015-08-18 | General Electric Company | Automated systems and methods for isolating regenerative cells from adipose tissue |
US8834928B1 (en) | 2011-05-16 | 2014-09-16 | Musculoskeletal Transplant Foundation | Tissue-derived tissugenic implants, and methods of fabricating and using same |
AR087158A1 (es) | 2011-06-20 | 2014-02-26 | Gen Biscuit | Masita en capas saludable |
WO2012178119A2 (en) | 2011-06-24 | 2012-12-27 | Arqos Surgical, Inc. | Tissue extraction devices and methods |
US9233193B2 (en) | 2011-06-29 | 2016-01-12 | Iogyn, Inc. | Surgical fluid management systems and methods |
US8369280B2 (en) | 2011-07-01 | 2013-02-05 | Ofinno Techologies, LLC | Control channels in multicarrier OFDM transmission |
EP2564611B1 (en) | 2011-07-01 | 2015-02-18 | Ofinno Technologies, LLC | Synchronization signal and control messages in multicarrier OFDM |
US8582527B2 (en) | 2011-07-01 | 2013-11-12 | Ofinno Technologies, Llc | Hybrid automatic repeat request in multicarrier systems |
US9737362B2 (en) | 2011-07-06 | 2017-08-22 | Boston Scientific Scimed, Inc. | Tissue cutting systems and methods |
US10967110B2 (en) | 2011-07-08 | 2021-04-06 | Jointechlabs, Inc. | System and methods for preparation of adipose-derived stem cells |
US11766459B2 (en) | 2011-07-08 | 2023-09-26 | Jointechlabs, Inc. | System and methods for preparation of adipose-derived stem cells |
US9931445B2 (en) * | 2011-07-08 | 2018-04-03 | Jointechlabs, Inc. | System and methods for preparation of adipose-derived stem cells |
US20150004702A1 (en) * | 2011-08-29 | 2015-01-01 | Stempeutics Research Private Limited | System for isolating stromal vascular fraction (svf) cells from the adipose tissue and a method thereof |
US9084847B2 (en) | 2011-09-22 | 2015-07-21 | Iogyn, Inc. | Surgical fluid management systems and methods |
SG10201606745XA (en) * | 2011-09-23 | 2016-10-28 | Cell Ideas Pty Ltd | Therapeutics using adipose cells and cell secretions |
US10154664B2 (en) | 2011-10-06 | 2018-12-18 | David K Moscatello | Systems and methods for the digestion of adipose tissue samples obtained from a client for cryopreservation |
JP5628131B2 (ja) * | 2011-10-19 | 2014-11-19 | サイトリ セラピューティクス インコーポレイテッド | 心血管状態の治療において脂肪組織由来細胞を使用する方法 |
US9597149B2 (en) | 2011-11-04 | 2017-03-21 | Iogyn, Inc. | Tissue extraction devices and methods |
EP2775928B1 (en) | 2011-11-08 | 2019-02-20 | Auxocell Laboratories Inc. | Systems and methods for processing cells |
US8427976B1 (en) | 2011-12-04 | 2013-04-23 | Ofinno Technology, LLC | Carrier information exchange between base stations |
US9512405B2 (en) | 2011-12-14 | 2016-12-06 | Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College | Non-enzymatic method for isolating human adipose-derived stromal stem cells |
CN105143446B (zh) | 2011-12-22 | 2020-11-03 | 詹森生物科技公司 | 人胚胎干细胞分化成单一激素胰岛素阳性细胞 |
US10751374B2 (en) | 2012-01-30 | 2020-08-25 | Michael P. Zahalsky | Methods and compositions for treatment of penile defects |
US20180028575A1 (en) | 2012-01-30 | 2018-02-01 | Michael Zahalsky | Methods and compositions for treatment of penile defects |
EP2818173B1 (en) * | 2012-02-24 | 2021-09-22 | Saeki, Masanori | Cell preparation including fat cell |
CN104160018A (zh) | 2012-03-07 | 2014-11-19 | 詹森生物科技公司 | 用于扩增和维持多能干细胞的成分确定的培养基 |
US9497756B2 (en) | 2012-03-25 | 2016-11-15 | Comcast Cable Communications, Llc | Base station radio resource management |
US9433645B2 (en) | 2012-04-13 | 2016-09-06 | Jeong Chan Ra | Method and composition for preventing stem cell disruption and aggregation |
US9949265B2 (en) | 2012-05-04 | 2018-04-17 | Comcast Cable Communications, Llc | Control channel in a wireless communication system |
WO2013180952A1 (en) | 2012-05-30 | 2013-12-05 | Lifecell Corporation | Device for harvesting, processing, and transferring adipose tissue |
RU2018108850A (ru) | 2012-06-08 | 2019-02-26 | Янссен Байотек, Инк. | Дифференцировка эмбриональных стволовых клеток человека в панкреатические эндокринные клетки |
DE102013209718B4 (de) | 2012-06-22 | 2015-09-10 | Human Med Ag | Vorrichtung zum Separieren von adulten Stammzellen |
ITGE20120084A1 (it) * | 2012-08-24 | 2014-02-25 | Carlo Tremolada | Derivato tissutale di origine non embrionale arricchito di elementi staminali e multipotenti e metodo di preparazione di un medicamento con tale derivato |
US9642956B2 (en) | 2012-08-27 | 2017-05-09 | Biomet Biologics, Llc | Apparatus and method for separating and concentrating fluids containing multiple components |
CN104684493B (zh) * | 2012-08-29 | 2017-10-31 | 优而美股份公司 | 用于脂肪组织提取和再注入的仪器 |
BR112015004003B1 (pt) | 2012-09-06 | 2020-05-19 | The Gid Group Inc | aparelho para processar material biológico humano contendo tecido fibroso e método para processar tecido adiposo |
US20140081237A1 (en) * | 2012-09-20 | 2014-03-20 | Tissue Genesis, Inc. | Hand-held micro-liposuction adipose harvester, processor, and cell concentrator |
CA2868862C (en) | 2012-09-25 | 2017-06-27 | Stem Cell Partners Llc | Method and apparatus for preparing single donor thrombin serum |
KR20150046274A (ko) * | 2012-09-28 | 2015-04-29 | 스위스 스템 셀 파운데이션 | 정제된 줄기세포 분획의 제조를 위한 고-안전성 방법 |
US9498244B2 (en) | 2012-10-19 | 2016-11-22 | Iogyn, Inc. | Medical systems and methods |
DK2913059T3 (en) | 2012-10-25 | 2018-06-25 | Genomix Co Ltd | Hitherto UNKNOWN PROCEDURE FOR TREATMENT OF SPINE INJURY USING HMGB1 FRAGMENT |
BR112015009037A2 (pt) | 2012-10-25 | 2017-11-14 | Genomix Co Ltd | composição farmacêutica para uso no tratamento de infarto do miocárdio e uso de um peptídeo de fragmento de hmgb1 |
KR102030028B1 (ko) * | 2012-11-12 | 2019-10-08 | 한스바이오메드 주식회사 | 지방 조직 농축 시스템 |
US9468709B2 (en) | 2012-11-12 | 2016-10-18 | Shippert Enterprises, Llc | Syringe fill method and apparatus |
US10138465B2 (en) | 2012-12-31 | 2018-11-27 | Janssen Biotech, Inc. | Differentiation of human embryonic stem cells into pancreatic endocrine cells using HB9 regulators |
US10370644B2 (en) | 2012-12-31 | 2019-08-06 | Janssen Biotech, Inc. | Method for making human pluripotent suspension cultures and cells derived therefrom |
DK2938724T3 (da) | 2012-12-31 | 2020-12-14 | Janssen Biotech Inc | Dyrkning af humane embryonale stamceller ved luft-væskegrænsefladen til differentiering til endokrine pankreasceller |
WO2014106141A1 (en) | 2012-12-31 | 2014-07-03 | Janssen Biotech, Inc. | Suspension and clustering of human pluripotent cells for differentiation into pancreatic endocrine cells |
US9775864B2 (en) | 2013-01-31 | 2017-10-03 | Ams Research Corporation | Vaginal laxity therapy utilizing cell-based bulking compositions |
US9650608B2 (en) | 2013-02-22 | 2017-05-16 | Medivet America, Llc | Activating adipose-derived stem cells for transplantation |
US9867939B2 (en) | 2013-03-12 | 2018-01-16 | Allergan, Inc. | Adipose tissue combinations, devices, and uses thereof |
US9895418B2 (en) | 2013-03-15 | 2018-02-20 | Biomet Biologics, Llc | Treatment of peripheral vascular disease using protein solutions |
US10143725B2 (en) | 2013-03-15 | 2018-12-04 | Biomet Biologics, Llc | Treatment of pain using protein solutions |
US9950035B2 (en) | 2013-03-15 | 2018-04-24 | Biomet Biologics, Llc | Methods and non-immunogenic compositions for treating inflammatory disorders |
US20140271589A1 (en) | 2013-03-15 | 2014-09-18 | Biomet Biologics, Llc | Treatment of collagen defects using protein solutions |
US10208095B2 (en) | 2013-03-15 | 2019-02-19 | Biomet Manufacturing, Llc | Methods for making cytokine compositions from tissues using non-centrifugal methods |
FR3003576B1 (fr) | 2013-03-25 | 2017-09-01 | Michel Roche | Dispositif et procede de traitement de cellules graisseuses, notamment pour nettoyer et filtrer les cellules graisseuses d’un patient en vue d’un lipofilling |
US9907563B2 (en) | 2013-04-08 | 2018-03-06 | Boston Scientific Scimed, Inc. | Medical systems and methods |
US10124126B2 (en) * | 2013-04-18 | 2018-11-13 | The Regents Of The University Of Colorado, A Body Corporate | System and methods for ventilation through a body cavity |
US9486233B2 (en) | 2013-04-26 | 2016-11-08 | Iogyn, Inc. | Tissue resecting systems and methods |
JP6362588B2 (ja) * | 2013-05-02 | 2018-07-25 | 正典 佐伯 | 毛髪再生用の細胞製剤 |
US20140350516A1 (en) | 2013-05-23 | 2014-11-27 | Allergan, Inc. | Mechanical syringe accessory |
EP3569694A1 (en) | 2013-06-11 | 2019-11-20 | President and Fellows of Harvard College | Sc-beta cells and compositions and methods for generating the same |
US9580678B2 (en) | 2013-06-21 | 2017-02-28 | The Regents Of The University Of California | Microfluidic tumor tissue dissociation device |
US20150037436A1 (en) | 2013-07-30 | 2015-02-05 | Musculoskeletal Transplant Foundation | Acellular soft tissue-derived matrices and methods for preparing same |
ITMO20130227A1 (it) * | 2013-08-02 | 2015-02-03 | Biomed Device Srl | Metodo e sistema per aliquotare grasso da liposuzione |
US10336980B2 (en) | 2013-09-05 | 2019-07-02 | The Gid Group, Inc. | Tissue processing apparatus and method for processing adipose tissue |
CN105764436B (zh) | 2013-09-06 | 2019-04-26 | 普罗赛普特生物机器人公司 | 利用致脱脉冲的用于消融组织的装置 |
MX2016003127A (es) | 2013-09-19 | 2016-10-28 | Cytori Therapeutics Inc | Metodos de uso de células derivadas de tejido adiposo en la modulación de dolor y/o fibrosis. |
US9248384B2 (en) | 2013-10-02 | 2016-02-02 | Allergan, Inc. | Fat processing system |
US9943639B2 (en) | 2013-10-28 | 2018-04-17 | Boston Scientific Scimed, Inc. | Fluid management system and methods |
BR102013033827B1 (pt) * | 2013-12-27 | 2021-09-08 | Regenera - Medicina Veterinária Avançada Ltda. | Concentrado multipotente e imunocompatível de células-tronco e biofármaco e forma de dosagem que o compreendem |
US10125345B2 (en) * | 2014-01-31 | 2018-11-13 | Dsm Ip Assets, B.V. | Adipose tissue centrifuge and method of use |
AU2015253669B2 (en) | 2014-05-02 | 2020-01-23 | Lifecell Corporation | Injection sensor with feedback mechanism |
US10029048B2 (en) | 2014-05-13 | 2018-07-24 | Allergan, Inc. | High force injection devices |
US10772997B2 (en) | 2014-05-15 | 2020-09-15 | Ronald D. Shippert | Tissue parcelization method and apparatus |
JP6588969B2 (ja) | 2014-05-16 | 2019-10-09 | ヤンセン バイオテツク,インコーポレーテツド | 膵内分泌細胞内のmafa発現を強化するための小分子の使用 |
CN106687154B (zh) | 2014-07-31 | 2021-02-09 | 史密夫和内修有限公司 | 用于施用减压治疗的系统和方法 |
US9993748B2 (en) | 2014-08-11 | 2018-06-12 | Auxocell Laboratories, Inc. | Centrifuge clip and method |
USD748462S1 (en) | 2014-08-11 | 2016-02-02 | Auxocell Laboratories, Inc. | Centrifuge clip |
US9988599B2 (en) | 2014-08-25 | 2018-06-05 | Reviticell Holdings, Inc. | Modular single-use kits and methods for preparation of biological material |
ES2842750T3 (es) * | 2014-09-05 | 2021-07-14 | Procept Biorobotics Corp | Aparato para el aislamiento de células |
TW201627498A (zh) * | 2015-01-26 | 2016-08-01 | 國立中央大學 | 用於純化及培養幹細胞的孔洞結構及其製造方法、幹細胞純化裝置及使用其的幹細胞純化方法、以及幹細胞培養裝置及使用其的幹細胞培養方法 |
EP3268063A4 (en) | 2015-03-10 | 2018-10-31 | Allergan Pharmaceuticals Holdings (Ireland) Unlimited Company | Multiple needle injector |
US9713810B2 (en) | 2015-03-30 | 2017-07-25 | Biomet Biologics, Llc | Cell washing plunger using centrifugal force |
CA2984874A1 (en) * | 2015-05-05 | 2016-11-10 | Samer Srouji | A fat-depleted adipose tissue and a device and method for preparing the same |
US9757721B2 (en) | 2015-05-11 | 2017-09-12 | Biomet Biologics, Llc | Cell washing plunger using centrifugal force |
EP3297694A1 (en) | 2015-05-21 | 2018-03-28 | Musculoskeletal Transplant Foundation | Modified demineralized cortical bone fibers |
WO2016196957A1 (en) * | 2015-06-05 | 2016-12-08 | Novartis Ag | Flow-through paramagnetic particle-based cell separation and paramagnetic particle removal |
US10912864B2 (en) | 2015-07-24 | 2021-02-09 | Musculoskeletal Transplant Foundation | Acellular soft tissue-derived matrices and methods for preparing same |
JP7057557B2 (ja) * | 2015-07-31 | 2022-04-20 | 国立大学法人大阪大学 | 上皮疾患に対する治療及び/又は予防有効性を評価する方法、上皮疾患治療剤のスクリーニング方法、及び上皮疾患治療剤 |
US11052175B2 (en) | 2015-08-19 | 2021-07-06 | Musculoskeletal Transplant Foundation | Cartilage-derived implants and methods of making and using same |
US10188777B2 (en) | 2015-08-20 | 2019-01-29 | Aurastem Llc | Liposuction device and system and use thereof |
CN108291201A (zh) | 2015-10-21 | 2018-07-17 | 生命细胞公司 | 用于医疗装置控制的系统和方法 |
WO2017070493A1 (en) | 2015-10-21 | 2017-04-27 | Lifecell Corporation | Systems and methods for tube management |
EP3381458B1 (en) * | 2015-11-24 | 2023-06-07 | Rohto Pharmaceutical Co., Ltd. | Therapeutic agent for liver disease containing stromal cells derived from adipose tissue and method for producing the same |
EP3393390A1 (en) | 2015-12-22 | 2018-10-31 | LifeCell Corporation | Syringe filling device for fat transfer |
US10722540B1 (en) | 2016-02-01 | 2020-07-28 | The Regents Of The University Of California | Microfluidic device and method for shear stress-induced transformation of cells |
EP3220298A1 (en) | 2016-03-14 | 2017-09-20 | Fenwal, Inc. | Cell processing system and method with process parameter control |
KR101733564B1 (ko) * | 2016-03-15 | 2017-05-10 | 경북대학교병원 | 디케토피페라진을 유효성분으로 포함하는 전신염증질환의 예방 또는 치료용 약학적 조성물 |
BR112018068820B1 (pt) | 2016-03-17 | 2022-11-16 | Synova Life Sciences, Inc | Método para isolar células-tronco do tecido adiposo e dispositivo para realizar o dito método |
BR112018070642A2 (pt) | 2016-04-08 | 2019-02-05 | Allergan Inc | dispositivo de aspiração e injeção |
MA45479A (fr) | 2016-04-14 | 2019-02-20 | Janssen Biotech Inc | Différenciation de cellules souches pluripotentes en cellules de l'endoderme de l'intestin moyen |
CN105955743B (zh) | 2016-04-29 | 2019-08-27 | 腾讯科技(深圳)有限公司 | 资源数值转移请求生成的方法、装置和系统 |
EP3238760B1 (en) * | 2016-04-29 | 2019-10-02 | Fenwal, Inc. | System and method for selecting and culturing cells |
US10251990B2 (en) | 2016-04-29 | 2019-04-09 | Fenwal, Inc. | System and method for processing, incubating, and/or selecting biological cells |
US10702629B2 (en) * | 2016-05-13 | 2020-07-07 | Black Tie Medical Inc. | Conditioning harvested fat for re-injection |
US11191879B2 (en) | 2016-05-27 | 2021-12-07 | Fenwal, Inc. | Cell processing system and method with preliminary process evaluation |
JP7072228B2 (ja) | 2016-06-08 | 2022-05-20 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 組織および細胞を処理するための方法および装置 |
US10654000B2 (en) | 2016-07-13 | 2020-05-19 | Fenwal, Inc. | Cell processing system and method with centralized data management, monitoring and/or control |
DE102016114043B3 (de) * | 2016-07-29 | 2017-08-10 | Technische Universität Dresden | Vorrichtung zur Isolierung von Stammzellen aus fötalen Geweben |
EP3506957A1 (en) | 2016-08-30 | 2019-07-10 | LifeCell Corporation | Systems and methods for medical device control |
US11116945B2 (en) | 2016-11-02 | 2021-09-14 | Stemplant, Llc | Method and apparatus for delivery of cell therapies |
EP3338823B1 (en) | 2016-12-21 | 2021-06-16 | Fenwal, Inc. | System and method for separating cells incorporating magnetic separation |
US20180207331A1 (en) * | 2017-01-20 | 2018-07-26 | Puregraft Llc | Chamber for the collection of lipoaspirate |
WO2018139562A1 (ja) | 2017-01-27 | 2018-08-02 | 株式会社ジェノミックス | 心筋症、陳旧性心筋梗塞および慢性心不全の治療薬 |
USD851777S1 (en) | 2017-01-30 | 2019-06-18 | Lifecell Corporation | Canister-type device for tissue processing |
WO2018187808A1 (en) | 2017-04-07 | 2018-10-11 | Epibone, Inc. | System and method for seeding and culturing |
EP3612242A1 (en) | 2017-04-19 | 2020-02-26 | Smith & Nephew, Inc | Negative pressure wound therapy canisters |
BR112019022148A2 (pt) | 2017-04-28 | 2020-05-12 | Aurastem Llc | Dispositivos de agulha de microlipo e uso respectivo |
ES2945416T3 (es) | 2017-06-06 | 2023-07-03 | Thoracent Inc | Aparato para realizar una broncoscopia |
US11732233B2 (en) | 2017-07-18 | 2023-08-22 | Gid Bio, Inc. | Adipose tissue digestion system and tissue processing method |
US11298403B2 (en) | 2017-12-01 | 2022-04-12 | StemRIM Inc. | Therapeutic agent for inflammatory bowel disease |
GB201720405D0 (en) | 2017-12-07 | 2018-01-24 | Biosafe Sa | A bioprocessing system |
CN115722351A (zh) * | 2018-04-02 | 2023-03-03 | 联合技术实验室公司 | 用于制备脂肪来源干细胞的系统和方法 |
CN108676702B (zh) * | 2018-05-23 | 2021-10-15 | 上海蓓蕊医疗科技有限公司 | 一种提取装置及其操作方法 |
US12023356B2 (en) | 2018-07-04 | 2024-07-02 | Masanori Saeki | Stem cell filtrate preparation and method for preparing same |
WO2020174005A1 (en) | 2019-02-28 | 2020-09-03 | The Regenerative Group Ltd. | Regenerative combination of plasma and adipose tissue |
US20200325436A1 (en) * | 2019-04-10 | 2020-10-15 | Advanced Solutions Life Sciences, Llc | Systems and Methods For Isolating Microvessels From Adipose Tissue |
US11234684B2 (en) | 2019-04-19 | 2022-02-01 | Transmed7, Llc | Devices and methods for portable, adjunctive vacuum source and cytology/histology collection systems for biopsy devices |
RU195366U1 (ru) * | 2019-05-08 | 2020-01-23 | Федеральное государственное бюджетное учреждение "Национальный медицинский исследовательский центр реабилитации и курортологии" Министерства здравоохранения Российской Федерации (ФГБУ НМИЦ РК Минздрава России) | Устройство для выделения из жировой ткани клеток стромально-васкулярной фракции для последующего их применения в регенеративной медицине |
US20220411759A1 (en) | 2019-05-21 | 2022-12-29 | President And Fellows Of Harvard College | Endocrine differentiation-inducing molecule |
WO2020263858A1 (en) * | 2019-06-24 | 2020-12-30 | The Regents Of The University Of California | Integrated system for mechanical processing of lipoaspirate |
WO2020264084A1 (en) | 2019-06-27 | 2020-12-30 | Boston Scientific Scimed, Inc. | Detection of an endoscope to a fluid management system |
EP3770600B1 (en) * | 2019-07-25 | 2023-05-10 | CSEM Centre Suisse d'Electronique et de Microtechnique SA - Recherche et Développement | Purification process for cells |
EP4025289A4 (en) | 2019-09-02 | 2023-11-01 | Stemplant, LLC | METHOD AND DEVICE FOR ADMINISTRATION OF CELL THERAPIES |
US11272996B2 (en) | 2019-10-04 | 2022-03-15 | Reviticell Holdings, Inc. | Methods and devices for performing sequential procedures utilizing a standardized system |
US20230020665A1 (en) * | 2019-11-22 | 2023-01-19 | Siemens Healthcare Diagnostics Inc. | Apparatus, systems, and methods of transferring liquids containing aggregates |
BR112022016333A2 (pt) * | 2020-02-18 | 2022-10-04 | Apyx Medical Corp | Dispositivos, sistemas e métodos para detectar, e discernir entre, tecido adiposo e muscular durante procedimentos médicos |
GB2587257B (en) | 2020-03-09 | 2021-09-15 | Alma Lasers Ltd | Lipoaspirate processing |
WO2021190340A1 (zh) * | 2020-03-27 | 2021-09-30 | 康博医创股份有限公司 | 一种用于富集和检测生物样品中微生物的方法和装置 |
US20230167397A1 (en) | 2020-04-22 | 2023-06-01 | Cellunite Gmbh | Modular cell processing |
US20230167398A1 (en) | 2020-04-22 | 2023-06-01 | Cellunite Gmbh | System and method for automated cell processing |
EP4143292A2 (en) * | 2020-04-30 | 2023-03-08 | Scicotec GmbH | Automated integrated liposuction and tissue processing device and method |
CN111557952A (zh) * | 2020-05-28 | 2020-08-21 | 澳门大学 | 间充质干细胞在制备用于促进脂肪移植的制剂中的应用 |
WO2021247952A2 (en) * | 2020-06-05 | 2021-12-09 | Duke University | Compositions and methods for augmenting autologous fat grafts |
WO2022056198A1 (en) * | 2020-09-14 | 2022-03-17 | Ginkgo Bioworks, Inc. | Use of bone morphogenetic proteins and their receptors for aesthetics and cosmetics |
US20230383259A1 (en) * | 2020-09-15 | 2023-11-30 | The Brigham And Women's Hospital, Inc. | In vivo adipose bioreactor and kits for the production and delivery of biologic agents |
JP2024513520A (ja) | 2021-04-11 | 2024-03-25 | プレジデント アンド フェローズ オブ ハーバード カレッジ | 心筋細胞及び組成物ならびにそれらの生産方法 |
US11679198B2 (en) | 2021-04-28 | 2023-06-20 | Chopra Gryskiewicz, LLC | System and related methods for fat harvesting |
EP4373913A1 (en) | 2021-07-23 | 2024-05-29 | CellUnite GmbH | System and method for cell processing |
CN113976339A (zh) * | 2021-10-25 | 2022-01-28 | 安然 | 改进式脂肪移植装置 |
Family Cites Families (210)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4000275A (en) * | 1969-11-24 | 1976-12-28 | Eli Lilly And Company | Immunosuppressants |
US6436135B1 (en) * | 1974-10-24 | 2002-08-20 | David Goldfarb | Prosthetic vascular graft |
US4346703A (en) | 1979-01-23 | 1982-08-31 | Baxter Travenol Laboratories, Inc. | Solution container for continuous ambulatory peritoneal dialysis |
US4458678A (en) | 1981-10-26 | 1984-07-10 | Massachusetts Institute Of Technology | Cell-seeding procedures involving fibrous lattices |
US4418691A (en) * | 1981-10-26 | 1983-12-06 | Massachusetts Institute Of Technology | Method of promoting the regeneration of tissue at a wound |
IT1212892B (it) | 1983-10-11 | 1989-11-30 | Della Valle Francesco | Acido ialuronico ottenuto per mezzodi filtrazione molecolare sprovvisto di attivita' infiammatoria e sua utilizzazione terapeutica |
JPS5990649A (ja) | 1982-11-12 | 1984-05-25 | Hitachi Koki Co Ltd | 無菌式連続遠心分離システム |
JPS5990649U (ja) | 1982-12-10 | 1984-06-19 | トヨタ自動車株式会社 | オ−トマチツク車の変速位置表示装置 |
US5034135A (en) | 1982-12-13 | 1991-07-23 | William F. McLaughlin | Blood fractionation system and method |
US4699788A (en) | 1984-08-20 | 1987-10-13 | Trustees Of Boston University | Angiogenic factor methods of extraction and method for producing angiogenesis |
JPH022884Y2 (ja) | 1984-12-25 | 1990-01-24 | ||
US4820626A (en) | 1985-06-06 | 1989-04-11 | Thomas Jefferson University | Method of treating a synthetic or naturally occuring surface with microvascular endothelial cells, and the treated surface itself |
US5035708A (en) | 1985-06-06 | 1991-07-30 | Thomas Jefferson University | Endothelial cell procurement and deposition kit |
US5312380A (en) * | 1985-06-06 | 1994-05-17 | Thomas Jefferson University | Endothelial cell procurement and deposition kit |
US5372945A (en) * | 1985-06-06 | 1994-12-13 | Alchas; Paul G. | Device and method for collecting and processing fat tissue and procuring microvessel endothelial cells to produce endothelial cell product |
US4734269A (en) | 1985-06-11 | 1988-03-29 | American Hospital Supply Corporation | Venous reservoir bag with integral high-efficiency bubble removal system |
US5436135A (en) * | 1985-09-02 | 1995-07-25 | Pasteur Merieux Serums Et Vaccins | New preparation of placenta collagen, their extraction method and their applications |
EP0244447A1 (en) | 1985-10-25 | 1987-11-11 | ATTIKIOUZEL, Yianni | Warning system for rear end vehicle collisions |
US4990333A (en) | 1985-12-20 | 1991-02-05 | Angio Medical Corporation | Method for healing bone damage |
ES2004281A6 (es) | 1986-04-04 | 1988-12-16 | Univ Jefferson | Una superficie protesica implantable para implantacion en un paciente humano |
US4963489A (en) * | 1987-04-14 | 1990-10-16 | Marrow-Tech, Inc. | Three-dimensional cell and tissue culture system |
US5079160A (en) * | 1987-06-08 | 1992-01-07 | Lacy Paul E | Method to isolate clusters of cell subtypes from organs |
US5158867A (en) * | 1987-08-21 | 1992-10-27 | Cryolife Inc. | Method for cryopreserving blood vessels |
US4883755A (en) | 1987-10-28 | 1989-11-28 | Thomas Jefferson University | Method of reendothelializing vascular linings |
US4834703A (en) * | 1987-11-23 | 1989-05-30 | Dubrul Will R | Liposuction filter and lipoplasty device |
JPH01141583A (ja) | 1987-11-27 | 1989-06-02 | Shimadzu Corp | 細胞処理チャンバ |
US5143063A (en) * | 1988-02-09 | 1992-09-01 | Fellner Donald G | Method of removing adipose tissue from the body |
JP2564611B2 (ja) | 1988-06-13 | 1996-12-18 | 株式会社日立製作所 | 生物細胞用遠心分離装置及び細胞の分離方法 |
US4897185A (en) * | 1988-10-06 | 1990-01-30 | Cobe Laboratories, Inc. | Cell processing apparatus and method |
US5092883A (en) * | 1988-12-28 | 1992-03-03 | Eppley Barry L | Method for promoting soft connective tissue growth and repair in mammals |
US5087244A (en) | 1989-01-31 | 1992-02-11 | C. R. Bard, Inc. | Catheter and method for locally applying medication to the wall of a blood vessel or other body lumen |
JPH0666B2 (ja) | 1989-05-02 | 1994-01-05 | 倉敷紡績株式会社 | Dnaの単離精製法 |
US5521087A (en) | 1989-05-10 | 1996-05-28 | Massachusetts Institute Of Technology | Method for producing oriented connective tissue cells in a ligament configuration |
EP0418979A3 (en) | 1989-09-21 | 1992-03-04 | Michele Dr. Zocchi | Method and apparatus for producing human autologous collagen |
DE69018246T2 (de) | 1990-02-09 | 1995-11-02 | Becton Dickinson Co | Vorrichtung zur Sammlung und Verarbeitung von fetten Geweben zur Herstellung von Endothel-Zellprodukt. |
EP0448770A1 (en) | 1990-03-28 | 1991-10-02 | Katsuya Takasu | Method for separating collagen |
US5641622A (en) | 1990-09-13 | 1997-06-24 | Baxter International Inc. | Continuous centrifugation process for the separation of biological components from heterogeneous cell populations |
JPH0675497B2 (ja) | 1990-11-15 | 1994-09-28 | 倉敷紡績株式会社 | プラスミド分離装置 |
US5837539A (en) * | 1990-11-16 | 1998-11-17 | Osiris Therapeutics, Inc. | Monoclonal antibodies for human mesenchymal stem cells |
US6010696A (en) * | 1990-11-16 | 2000-01-04 | Osiris Therapeutics, Inc. | Enhancing hematopoietic progenitor cell engraftment using mesenchymal stem cells |
US5811094A (en) | 1990-11-16 | 1998-09-22 | Osiris Therapeutics, Inc. | Connective tissue regeneration using human mesenchymal stem cell preparations |
US5226914A (en) * | 1990-11-16 | 1993-07-13 | Caplan Arnold I | Method for treating connective tissue disorders |
US5486359A (en) * | 1990-11-16 | 1996-01-23 | Osiris Therapeutics, Inc. | Human mesenchymal stem cells |
US6197325B1 (en) * | 1990-11-27 | 2001-03-06 | The American National Red Cross | Supplemented and unsupplemented tissue sealants, methods of their production and use |
US5234608A (en) | 1990-12-11 | 1993-08-10 | Baxter International Inc. | Systems and methods for processing cellular rich suspensions |
JP2637297B2 (ja) | 1991-02-22 | 1997-08-06 | 帝人株式会社 | 遠心分離装置 |
NZ242533A (en) | 1991-05-03 | 1995-05-26 | Becton Dickinson Co | Device for collecting and processing fat tissue; vessel with rinsing and digesting chamber, drain chamber and isolation chamber |
JPH0611309B2 (ja) | 1991-05-28 | 1994-02-16 | 克弥 高須 | コラーゲン採取装置 |
US5851832A (en) * | 1991-07-08 | 1998-12-22 | Neurospheres, Ltd. | In vitro growth and proliferation of multipotent neural stem cells and their progeny |
US5261612A (en) * | 1991-10-09 | 1993-11-16 | Newman-Ftaiha, Inc. | Method and apparatus for extracting injectable collagen from adipose tissue |
WO1993007824A1 (en) | 1991-10-18 | 1993-04-29 | Baxter International Inc. | Bone marrow kit |
US5549674A (en) * | 1992-03-02 | 1996-08-27 | The Regents Of The University Of Michigan | Methods and compositions of a bioartificial kidney suitable for use in vivo or ex vivo |
AU665813B2 (en) | 1992-05-11 | 1996-01-18 | Sulzer Medizinaltechnik Ag | Process and apparatus for producing endoprostheses |
AU4543193A (en) * | 1992-06-22 | 1994-01-24 | Henry E. Young | Scar inhibitory factor and use thereof |
AU4678993A (en) | 1992-07-16 | 1994-02-14 | Board Of Trustees Of The Leland Stanford Junior University | Methods for using dendritic cells to activate t cells |
US5336178A (en) | 1992-11-02 | 1994-08-09 | Localmed, Inc. | Intravascular catheter with infusion array |
US5654186A (en) * | 1993-02-26 | 1997-08-05 | The Picower Institute For Medical Research | Blood-borne mesenchymal cells |
US5328459A (en) * | 1993-05-06 | 1994-07-12 | Laghi Aldo A | Apparatus and method for dispensing and aspirating high viscosity materials |
JP3331398B2 (ja) * | 1993-05-28 | 2002-10-07 | バクスター、インターナショナル、インコーポレイテッド | 不均質な細胞混合物から特定の細胞集団を分離するための方法、装置およびシステム |
US5316942A (en) * | 1993-06-16 | 1994-05-31 | Battelle Memorial Institute | Process for the production of low-cost soluble high-molecular weight collagen |
US5409833A (en) * | 1993-07-01 | 1995-04-25 | Baxter International Inc. | Microvessel cell isolation apparatus |
US5591625A (en) * | 1993-11-24 | 1997-01-07 | Case Western Reserve University | Transduced mesenchymal stem cells |
US5470307A (en) * | 1994-03-16 | 1995-11-28 | Lindall; Arnold W. | Catheter system for controllably releasing a therapeutic agent at a remote tissue site |
JPH07255469A (ja) | 1994-03-17 | 1995-10-09 | Kurabo Ind Ltd | 動物細胞の凍結保存液 |
US5599335A (en) | 1994-03-29 | 1997-02-04 | The Procter & Gamble Company | Absorbent members for body fluids having good wet integrity and relatively high concentrations of hydrogel-forming absorbent polymer |
US5811050A (en) * | 1994-06-06 | 1998-09-22 | Gabower; John F. | Electromagnetic interference shield for electronic devices |
US5968753A (en) | 1994-06-14 | 1999-10-19 | Nexell Therapeutics, Inc. | Positive and positive/negative cell selection mediated by peptide release |
JP3687975B2 (ja) * | 1994-07-01 | 2005-08-24 | エドワーズ ライフサイエンシーズ コーポレイション | 自己由来の微小血管内皮細胞を含む脂肪組織を採取する方法 |
WO1996001641A1 (de) * | 1994-07-08 | 1996-01-25 | Sulzer Medizinaltechnik Ag | Verfahren zur herstellung von implantationsmaterialien |
FR2723315B1 (fr) * | 1994-08-02 | 1996-10-25 | Cird Galderma | Procede et composition pour stimuler la differenciation des cellules preadipocytaires et traitements therapeutiques associes |
DE4439480C1 (de) | 1994-11-08 | 1996-06-05 | Asta Medica Ag | Verwendung von D,L- alpha-Liponsäure und/oder ihren Enantiomeren, und/oder ihren Derivaten als Zusatz bei Erythrozyten-Flüssigkonserven für homologe und autologe Erythrozyten-Konzentrate und als Zusatz bei Erythrozyten-Kryokonserven für homologe und autologe Erythrozytenkonzentrate |
US5688531A (en) * | 1994-12-23 | 1997-11-18 | Ramot University Authority For Applied Research And Industrial Development, Ltd. | Method for regulating bone forming cells |
US5736396A (en) * | 1995-01-24 | 1998-04-07 | Case Western Reserve University | Lineage-directed induction of human mesenchymal stem cell differentiation |
US5906934A (en) * | 1995-03-14 | 1999-05-25 | Morphogen Pharmaceuticals, Inc. | Mesenchymal stem cells for cartilage repair |
US6238908B1 (en) | 1995-06-07 | 2001-05-29 | Aastrom Biosciences, Inc. | Apparatus and method for maintaining and growth biological cells |
US5888409A (en) * | 1995-06-07 | 1999-03-30 | Cedars-Sinai Medical Center | Methods for cell isolation and collection |
US5783408A (en) * | 1995-06-07 | 1998-07-21 | Hamilton; Bradford S. | Method for screening potential anti-obesity agents |
US5653689A (en) | 1995-09-30 | 1997-08-05 | Abacus Design & Development, Inc. | Infusion catheter |
JP3781433B2 (ja) | 1995-11-16 | 2006-05-31 | ケース ウエスターン リザーブ ユニバーシティ | ヒト間葉幹細胞の試験管内軟骨形成誘導 |
WO1997026326A1 (en) | 1996-01-16 | 1997-07-24 | Depuy Orthopaedics, Inc. | Isolation of precursor cells from hematopoietic and non-hematopoietic tissues and their use |
US6200606B1 (en) * | 1996-01-16 | 2001-03-13 | Depuy Orthopaedics, Inc. | Isolation of precursor cells from hematopoietic and nonhematopoietic tissues and their use in vivo bone and cartilage regeneration |
US6206873B1 (en) * | 1996-02-13 | 2001-03-27 | El. En. S.P.A. | Device and method for eliminating adipose layers by means of laser energy |
JP3322595B2 (ja) * | 1996-03-28 | 2002-09-09 | テルモ株式会社 | フィルター装置および生体微細組織の分離・回収方法 |
JP4609807B2 (ja) | 1996-03-28 | 2011-01-12 | 雪印乳業株式会社 | 骨強化用医薬、飲食品及び飼料 |
US5830714A (en) | 1996-04-17 | 1998-11-03 | Molecular Biology Resources, Inc. | Biologically active fragment of bacillus stearothermophilus DNA polymerase |
AU2730497A (en) | 1996-04-17 | 1997-11-07 | Case Western Reserve University | Cryopreservation and extensive subculturing of human mesenchymal stem cells |
EP2311471A3 (en) | 1996-04-19 | 2013-05-15 | Osiris Therapeutics, Inc. | Regeneration and augmentation of bone using mesenchymal stem cells |
JP2000508922A (ja) | 1996-04-26 | 2000-07-18 | ケース ウエスターン リザーブ ユニバーシティ | 間葉幹細胞を用いる皮膚再生 |
US6020196A (en) * | 1996-05-09 | 2000-02-01 | Baxter International Inc. | Devices for harvesting and homogenizing adipose tissue containing autologous endothelial cells |
US5785965A (en) | 1996-05-15 | 1998-07-28 | The Board Of Trustees Of The Leland Stanford Junior Univ. | VEGF gene transfer into endothelial cells for vascular prosthesis |
US5869037A (en) | 1996-06-26 | 1999-02-09 | Cornell Research Foundation, Inc. | Adenoviral-mediated gene transfer to adipocytes |
US5727740A (en) * | 1996-07-03 | 1998-03-17 | Robinson; Forrest L. | Method and apparatus for recovering fractional components of soil |
JPH1017310A (ja) | 1996-07-03 | 1998-01-20 | Ehime Pref Gov | コラーゲン、ヒドロキシアパタイトの製造方法及びその生成物 |
US6368356B1 (en) * | 1996-07-11 | 2002-04-09 | Scimed Life Systems, Inc. | Medical devices comprising hydrogel polymers having improved mechanical properties |
US5837444A (en) * | 1996-07-16 | 1998-11-17 | Shah; Kumarpal A. | Islet cell transplantation machine for diabetes cure |
US5827740A (en) * | 1996-07-30 | 1998-10-27 | Osiris Therapeutics, Inc. | Adipogenic differentiation of human mesenchymal stem cells |
US5919234A (en) | 1996-08-19 | 1999-07-06 | Macropore, Inc. | Resorbable, macro-porous, non-collapsing and flexible membrane barrier for skeletal repair and regeneration |
US5980887A (en) * | 1996-11-08 | 1999-11-09 | St. Elizabeth's Medical Center Of Boston | Methods for enhancing angiogenesis with endothelial progenitor cells |
AU5436998A (en) | 1996-11-15 | 1998-06-03 | Osiris Therapeutics, Inc. | MSC-megakaryocyte precursor composition and method of isolating MSCs asso ciated with isolated megakaryocytes by isolating megakaryocytes |
EP0941311B1 (de) | 1996-11-19 | 2004-07-28 | Boehringer Mannheim Gmbh | Rekombinante collagenase typ i aus clostridium histolyticum und ihre verwendung zur isolierung von zellen und zellverbänden |
US5728740A (en) * | 1996-12-05 | 1998-03-17 | Barrett; Mark William | Method and composition for treating bacterial infections in plants |
WO1998032333A1 (en) | 1996-12-06 | 1998-07-30 | Osiris Therapeutics, Inc. | Improved chondrogenic differentiation of human mesenchymal stem cells |
US5830741A (en) | 1996-12-06 | 1998-11-03 | Boehringer Mannheim Corporation | Composition for tissue dissociation containing collagenase I and II from clostridium histolyticum and a neutral protease |
CA2278208C (en) * | 1997-01-24 | 2011-09-20 | Asahi Medical Co., Ltd. | Cell separation method |
CA2289122C (en) | 1997-02-18 | 2009-04-21 | Lxr Biotechnology Inc. | Bak promoter expression system |
US7767452B2 (en) * | 1997-02-20 | 2010-08-03 | Kleinsek Don A | Tissue treatments with adipocyte cells |
US6086582A (en) * | 1997-03-13 | 2000-07-11 | Altman; Peter A. | Cardiac drug delivery system |
EP2110431A1 (en) | 1997-05-13 | 2009-10-21 | Osiris Therapeutics, Inc. | Cartilage regeneration using human mesenchymal stem cells |
DE69834397T2 (de) | 1997-05-20 | 2007-06-06 | Zymequest, Inc., Beverly | Vorrichtung zum Austreiben von Fluiden |
US5786207A (en) * | 1997-05-28 | 1998-07-28 | University Of Pittsburgh | Tissue dissociating system and method |
US5817050A (en) * | 1997-05-29 | 1998-10-06 | Klein; Jeffrey A. | Liposuction cannula |
US6451207B1 (en) | 1997-06-04 | 2002-09-17 | Dexter Magnetic Technologies, Inc. | Magnetic cell separation device |
JPH114682A (ja) | 1997-06-16 | 1999-01-12 | Asahi Medical Co Ltd | 有核細胞保存方法、有核細胞保存用組成物及び有核細胞分離方法 |
CA2294944A1 (en) | 1997-07-03 | 1999-01-14 | Osiris Therapeutics, Inc. | Human mesenchymal stem cells from peripheral blood |
JP4562816B2 (ja) * | 1997-07-14 | 2010-10-13 | オシリス セラピューティクス,インコーポレイテッド | 心筋再生のための間葉幹細胞の使用法および組成物 |
JPH1157731A (ja) | 1997-08-15 | 1999-03-02 | Japan Organo Co Ltd | 浄水処理方法および浄水処理設備 |
AU9472998A (en) | 1997-09-04 | 1999-03-22 | Science Research Laboratory, Inc. | Cell separation using electric fields |
US6077987A (en) | 1997-09-04 | 2000-06-20 | North Shore-Long Island Jewish Research Institute | Genetic engineering of cells to enhance healing and tissue regeneration |
US6269716B1 (en) | 1998-11-18 | 2001-08-07 | Macropore, Inc. | High-torque resorbable screws |
WO1999028444A1 (en) | 1997-12-02 | 1999-06-10 | Zen Bio, Inc. | Differentiation of adipose stromal cells into osteoblasts and uses thereof |
US6251295B1 (en) | 1998-01-08 | 2001-06-26 | Nexell Therapeutics Inc. | Method for recirculation washing of blood cells |
AU749358B2 (en) | 1998-01-23 | 2002-06-27 | Pall Corporation | Biological fluid treatment system |
WO1999046366A1 (en) | 1998-03-13 | 1999-09-16 | Osiris Therapeutics, Inc. | Uses for humane non-autologous mesenchymal stem cells |
US6206914B1 (en) * | 1998-04-30 | 2001-03-27 | Medtronic, Inc. | Implantable system with drug-eluting cells for on-demand local drug delivery |
AU4336599A (en) * | 1998-06-08 | 1999-12-30 | Osiris Therapeutics, Inc. | (in vitro) maintenance of hematopoietic stem cells |
US6001642A (en) | 1998-06-29 | 1999-12-14 | Wyle Laboratories, Inc. Life Sciences | Bioreactor and cell culturing processes using the bioreactor |
DE19841835C2 (de) | 1998-09-12 | 2003-05-28 | Fresenius Ag | Zentrifugenkammer für einen Zellseparator |
AU767241B2 (en) * | 1998-09-14 | 2003-11-06 | Qiang Xu | Immunosuppressive agents |
US6184035B1 (en) * | 1998-11-18 | 2001-02-06 | California Institute Of Technology | Methods for isolation and activation of, and control of differentiation from, skeletal muscle stem or progenitor cells |
US6090121A (en) * | 1998-12-02 | 2000-07-18 | Weber; Paul J. | Highly flexible, reinforced swan neck liposuction cannulas |
US6777231B1 (en) * | 1999-03-10 | 2004-08-17 | The Regents Of The University Of California | Adipose-derived stem cells and lattices |
US20030082152A1 (en) * | 1999-03-10 | 2003-05-01 | Hedrick Marc H. | Adipose-derived stem cells and lattices |
WO2000053795A1 (en) * | 1999-03-10 | 2000-09-14 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Adipose-derived stem cells and lattices |
JP4014350B2 (ja) | 1999-03-12 | 2007-11-28 | 株式会社神鋼環境ソリューション | 酵母液貯留用攪拌槽と、その攪拌槽を用いたビール等の発酵食品類の製造方法、並びにその攪拌槽に具備された攪拌翼 |
JP4195250B2 (ja) | 1999-03-12 | 2008-12-10 | 株式会社神鋼環境ソリューション | ビール等の発酵食品類の製造方法 |
US6764820B2 (en) | 1999-03-26 | 2004-07-20 | Ludwig Institute For Cancer Research | Screening for lymphatic disorders involving the FLT4 receptor tyrosine kinase (VEGFR-3) |
US20030211085A1 (en) * | 2000-03-16 | 2003-11-13 | Sanberg Paul R. | Cell therapy for chronic stroke |
US6316247B1 (en) | 1999-06-15 | 2001-11-13 | University Of Pittsburgh | System and method for refining liposuctioned adipose tissue |
US6804558B2 (en) * | 1999-07-07 | 2004-10-12 | Medtronic, Inc. | System and method of communicating between an implantable medical device and a remote computer system or health care provider |
US6429013B1 (en) | 1999-08-19 | 2002-08-06 | Artecel Science, Inc. | Use of adipose tissue-derived stromal cells for chondrocyte differentiation and cartilage repair |
US6555374B1 (en) * | 1999-08-19 | 2003-04-29 | Artecel Sciences, Inc. | Multiple mesodermal lineage differentiation potentials for adipose tissue-derived stromal cells and uses thereof |
CN1134537C (zh) * | 1999-09-08 | 2004-01-14 | 何清华 | 人原始间叶干细胞群的制备方法 |
AU7611500A (en) | 1999-09-24 | 2001-04-24 | Abt Holding Company | Pluripotent embryonic-like stem cells, compositions, methods and uses thereof |
US20030161817A1 (en) * | 2001-03-28 | 2003-08-28 | Young Henry E. | Pluripotent embryonic-like stem cells, compositions, methods and uses thereof |
JP3524835B2 (ja) | 2000-02-25 | 2004-05-10 | 財団法人地球環境産業技術研究機構 | 光合成培養装置及び培養方法 |
CA2400485C (en) * | 2000-02-26 | 2014-04-29 | Artecel Sciences, Inc. | Pleuripotent stem cells generated from adipose tissue-derived stromal cells and uses thereof |
US20070111935A1 (en) | 2000-04-06 | 2007-05-17 | Franco Wayne P | Combination growth factor therapy and cell therapy for treatment of acute and chronic diseases of the organs |
AU2001257436B2 (en) * | 2000-04-28 | 2005-07-14 | Children's Medical Center Corporation | Isolation of mesenchymal stem cells and use thereof |
AU2001264565B2 (en) | 2000-05-03 | 2006-12-07 | Vegenics Limited | A method for activating only the vascular endothelial growth factor receptor-3 and uses thereof |
US20030212024A1 (en) * | 2000-05-12 | 2003-11-13 | Keating Mark T | Compositions and methods for cell dedifferentiation and tissue regeneration |
US20040172283A1 (en) | 2003-02-09 | 2004-09-02 | Vanderveen Timothy W. | Medication management and event logger and analysis system |
US7094874B2 (en) | 2000-05-26 | 2006-08-22 | Bristol-Myers Squibb Co. | Soluble CTLA4 mutant molecules |
CA2777791A1 (en) * | 2000-09-18 | 2002-03-21 | Organogenesis Inc. | Methods for treating a patient using a bioengineered flat sheet graft prostheses |
JP4141122B2 (ja) * | 2000-11-06 | 2008-08-27 | サカセ・アドテック株式会社 | インフレータブル構造及びインフレータブル構造を備えたアレーアンテナ及びインフレータブル構造の展開方法 |
US6576464B2 (en) * | 2000-11-27 | 2003-06-10 | Geron Corporation | Methods for providing differentiated stem cells |
US7192445B2 (en) * | 2000-12-06 | 2007-03-20 | Astra Tech Ab | Medical prosthetic devices and implants having improved biocompatibility |
US6517526B1 (en) | 2000-12-29 | 2003-02-11 | Yehuda Tamari | Container for lyophilizing biological products |
FR2819265B1 (fr) | 2001-01-10 | 2004-01-02 | Centre Nat Rech Scient | Cellules du tissu adipeux extramedullaire et leurs applications dans la reconstitution des lignees hematopoietiques |
EP1361896A2 (en) | 2001-01-23 | 2003-11-19 | Boston Scientific Corporation | Localized myocardial injection method for treating ischemic myocardium |
US6723131B2 (en) | 2001-02-28 | 2004-04-20 | The Cleveland Clinic Foundation | Composite bone marrow graft material with method and kit |
CA2441289A1 (en) | 2001-03-15 | 2002-09-26 | Xiao, Yong-Fu | Method for therapeutically treating a clinically recognized form of cardiopathology in a living mammal |
AU2002256086A1 (en) | 2001-04-09 | 2002-10-21 | Medtronic, Inc. | Methods of isolating blood components using a centrifuge and uses thereof |
US6623959B2 (en) * | 2001-06-13 | 2003-09-23 | Ethicon, Inc. | Devices and methods for cell harvesting |
WO2003001329A2 (en) | 2001-06-20 | 2003-01-03 | Power Medical Interventions, Inc. | A method and system for integrated medical tracking |
WO2003002165A1 (en) * | 2001-06-28 | 2003-01-09 | Cook Biotech Incorporated | Graft prosthesis devices containing renal capsule collagen |
US20030054331A1 (en) * | 2001-09-14 | 2003-03-20 | Stemsource, Inc. | Preservation of non embryonic cells from non hematopoietic tissues |
KR20100018089A (ko) | 2001-11-09 | 2010-02-16 | 아르테셀 사이언스, 인크. | 각막 결함 및 안와내 결함 복원용의 지방조직 유래 스트로마 세포 및 이의 용도 |
JP2005508393A (ja) * | 2001-11-09 | 2005-03-31 | アーテセル・サイエンシズ・インコーポレーテツド | 胚および成人幹細胞をサポートするための間質細胞の使用の方法および組成物 |
US6833270B2 (en) * | 2001-11-27 | 2004-12-21 | Biorep Technologies, Inc. | Apparatus and method for isolating cells from organs |
US7595043B2 (en) | 2001-12-07 | 2009-09-29 | Cytori Therapeutics, Inc. | Method for processing and using adipose-derived stem cells |
US7771716B2 (en) | 2001-12-07 | 2010-08-10 | Cytori Therapeutics, Inc. | Methods of using regenerative cells in the treatment of musculoskeletal disorders |
JP4653952B2 (ja) | 2001-12-07 | 2011-03-16 | サイトリ セラピューティクス インコーポレイテッド | 処理済み脂肪吸引細胞で患者を治療するためのシステムと方法 |
US7514075B2 (en) * | 2001-12-07 | 2009-04-07 | Cytori Therapeutics, Inc. | Systems and methods for separating and concentrating adipose derived stem cells from tissue |
US7585670B2 (en) | 2001-12-07 | 2009-09-08 | Cytori Therapeutics, Inc. | Automated methods for isolating and using clinically safe adipose derived regenerative cells |
US7651684B2 (en) | 2001-12-07 | 2010-01-26 | Cytori Therapeutics, Inc. | Methods of using adipose tissue-derived cells in augmenting autologous fat transfer |
US8105580B2 (en) | 2001-12-07 | 2012-01-31 | Cytori Therapeutics, Inc. | Methods of using adipose derived stem cells to promote wound healing |
US8404229B2 (en) | 2001-12-07 | 2013-03-26 | Cytori Therapeutics, Inc. | Methods of using adipose derived stem cells to treat acute tubular necrosis |
US20050008626A1 (en) | 2001-12-07 | 2005-01-13 | Fraser John K. | Methods of using adipose tissue-derived cells in the treatment of cardiovascular conditions |
CN1620306A (zh) | 2001-12-20 | 2005-05-25 | 马克罗珀尔公司 | 采用从脂肪组织中提取的富含胶原的物质治疗病人的系统和方法 |
US20030161916A1 (en) | 2002-02-26 | 2003-08-28 | Roy Parker | Method for preparing food article |
WO2003073998A2 (en) | 2002-03-02 | 2003-09-12 | Board Of Regents, The University Of Texas System | Local production and/or delivery of anti-cancer agents by stromal cell precursors |
CA2478063A1 (en) | 2002-03-07 | 2003-10-02 | Ludwig Institute For Cancer Research | Lymphatic and blood endothelial cell genes |
AU2003220424A1 (en) | 2002-03-19 | 2003-10-08 | Advanced Research And Technology Transfer | Adipose stromal stem cells for tissue and vascular modification |
AU2003278212B2 (en) | 2002-07-31 | 2009-07-09 | Centre National De La Recherche Scientifique | Stem cells derived from adipous tissue and differentiated cells derived from said cells |
US20050271636A1 (en) | 2002-08-09 | 2005-12-08 | St. Jude Children's Research Hospital, Inc. | Diagnostic and therapeutic uses for prox 1 |
JP2004099471A (ja) | 2002-09-05 | 2004-04-02 | Cardio Corp | 心筋梗塞および心不全の治療薬 |
US20040136968A1 (en) | 2002-09-27 | 2004-07-15 | Verigen Ag | Autologous cells on a support matrix for tissue repair |
JP4923235B2 (ja) | 2002-12-06 | 2012-04-25 | 独立行政法人産業技術総合研究所 | 骨−軟骨組織の再生用移植体 |
DK1599575T3 (da) | 2003-02-20 | 2012-01-16 | Cytori Therapeutics Inc | Fremgangsmåder til anvendelse af adipøst vævs-afledte celler i behandlingen af kardiovaskulære tilstande |
JP2004272762A (ja) | 2003-03-11 | 2004-09-30 | Topcon Corp | 医療用ネットワークシステム、情報処理装置、課金処理方法、そのためのプログラム、および、このプログラムを記録した情報記録媒体 |
US20040193274A1 (en) | 2003-03-28 | 2004-09-30 | Trieu Hai H. | Materials and methods for augmenting and/or repairing intervertebral discs |
US20040197304A1 (en) | 2003-04-01 | 2004-10-07 | The Procter & Gamble Company And Alimentary Health, Ltd. | Methods of determining efficacy of treatments of inflammatory diseases of the bowel |
AU2004238302B2 (en) | 2003-05-07 | 2007-01-25 | Aleeva Medical, Inc | Device for treating back pain by re-establishing the exchange of nutrient and waste |
WO2005012480A2 (en) | 2003-06-25 | 2005-02-10 | Macropore Biosurgery Inc. | Systems and methods for separating and concentrating regenerative cells from tissue |
FR2859381B1 (fr) | 2003-09-05 | 2008-07-25 | Centre Nat Rech Scient | Utilisaton de cellules issues du tissu adipeux pour induire la formation d'un reseau vasculaire fonctionnel |
EP1670315B1 (en) | 2003-09-17 | 2017-04-19 | Cytori Therapeutics, Inc. | Methods of using adipose derived regenerative cells in the treatment of peripheral vascular disease |
JP4749331B2 (ja) | 2003-10-07 | 2011-08-17 | 株式会社バイオマスター | 脂肪由来前駆細胞の細胞分化 |
JP2007508018A (ja) | 2003-10-08 | 2007-04-05 | べト−ステム インコーポレイテッド | 新規の幹細胞組成物の調製法および使用法、ならびにこの組成物を含有するキット |
WO2005042730A2 (en) | 2003-11-04 | 2005-05-12 | Biomaster, Inc. | Method and system for preparing stem cells from fat tissue |
KR100835034B1 (ko) | 2003-12-25 | 2008-06-03 | 도꾸리쯔교세이호징 가가꾸 기쥬쯔 신꼬 기꼬 | 포유동물의 골수 세포 또는 제대혈 유래 세포와 지방조직을 이용한 심근 세포의 유도 |
US20060025338A1 (en) | 2004-03-08 | 2006-02-02 | Ludwig Institute For Cancer Research | Compositions and methods for treatment of lymphatic and venous vessel arterialization |
JP4731556B2 (ja) | 2004-07-02 | 2011-07-27 | サイトリ セラピューティクス インコーポレイテッド | 臨床的に安全な脂肪組織由来再生細胞を単離し、使用するためのシステムおよび方法 |
WO2006028648A2 (en) | 2004-08-13 | 2006-03-16 | The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc. | Support system for flexible lyophilization containers |
US20090104159A1 (en) | 2005-02-10 | 2009-04-23 | Felipe Prosper | Vascular/Lymphatic Endothelial Cells |
EP1885382B1 (en) | 2005-05-25 | 2011-03-02 | Cytori Therapeutics, Inc. | Methods of using adipose tissue-derived cells in the treatment of cardiovascular conditions |
CA2642129C (en) | 2006-02-09 | 2012-08-21 | Aderans Research Institute, Inc. | Apparatus and methods for delivering fluid and material to a subject |
FR2901136B1 (fr) | 2006-05-18 | 2010-10-01 | Centre Nat Rech Scient | Utilisation de cellules derivees du tissu adipeux pour la preparation d'un medicament anti-tumoral |
WO2008013863A2 (en) | 2006-07-26 | 2008-01-31 | Cytori Therapeutics, Inc. | Generation of adipose tissue and adipocytes |
WO2009076548A1 (en) | 2007-12-13 | 2009-06-18 | Cytori Therapeutics, Inc. | Methods of inhibiting tumor development using adipose-derived regenerative cells |
WO2010124235A1 (en) | 2009-04-23 | 2010-10-28 | Cytori Therapeutics, Inc. | Use adipose tissue-derived regenerative cells in the modulation of inflammation in the pancreas and in the kidney |
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