KR102809774B1 - 합성 면역 수용체 및 이의 사용 방법 - Google Patents
합성 면역 수용체 및 이의 사용 방법 Download PDFInfo
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- KR102809774B1 KR102809774B1 KR1020197018673A KR20197018673A KR102809774B1 KR 102809774 B1 KR102809774 B1 KR 102809774B1 KR 1020197018673 A KR1020197018673 A KR 1020197018673A KR 20197018673 A KR20197018673 A KR 20197018673A KR 102809774 B1 KR102809774 B1 KR 102809774B1
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- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
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| CN113286879B (zh) | 2018-06-01 | 2025-06-13 | 安吉勒斯治疗公司 | 用于细胞疗法之多样化抗原结合域、新颖平台及其他增强子 |
| WO2019236647A1 (en) * | 2018-06-05 | 2019-12-12 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Artificial antigen presenting cells comprising protein l for expanding immune cells for immunotherapy |
| US20210236547A1 (en) * | 2018-06-05 | 2021-08-05 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Rapid production, expansion, and increased purity of car-t cells using beads with protein l |
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| KR20210022004A (ko) | 2018-06-18 | 2021-03-02 | 안위타 바이오사이언시스, 인코포레이티드 | 항-메소텔린 작제물 및 이의 용도 |
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| EP3844282A4 (en) * | 2018-08-29 | 2022-06-01 | Nanjing Legend Biotech Co., Ltd. | ANTI-MESOTHELIN CHIMERAL ANTIGEN RECEPTOR (CAR) CONSTRUCTS AND THEIR USES |
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| KR20210089712A (ko) * | 2018-11-07 | 2021-07-16 | 크리스퍼 테라퓨틱스 아게 | 항-cd33 면역세포 암 치료법 |
| US11673964B2 (en) * | 2018-12-19 | 2023-06-13 | The Trustees Of The University Of Pennsylvania | Use of CD2/5/7 knock-out anti-CD2/5/7 chimeric antigen receptor T cells against T cell lymphomas and leukemias |
| CN113226475A (zh) * | 2018-12-26 | 2021-08-06 | 麒麟控股株式会社 | 改造tcr及其制造方法 |
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| WO2020150702A1 (en) * | 2019-01-18 | 2020-07-23 | University Of Southern California | Methods and compositions to improve the safety and efficacy of cellular therapies |
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| MX2021009975A (es) * | 2019-02-22 | 2021-12-10 | Memorial Sloan Kettering Cancer Center | Anticuerpos de cd33 y métodos para usar los mismos para tratar el cáncer. |
| US12448429B2 (en) | 2019-03-06 | 2025-10-21 | Dana-Farber Cancer Institute, Inc. | T cell receptors specific to b-cell maturation antigen for treatment of cancer |
| US20220175781A1 (en) * | 2019-03-08 | 2022-06-09 | Obsidian Therapeutics, Inc. | Cd40l compositions and methods for tunable regulation |
| CN120944827A (zh) * | 2019-03-27 | 2025-11-14 | 宾夕法尼亚大学董事会 | Tn-MUC1嵌合抗原受体(CAR)T细胞疗法 |
| EP3952885A4 (en) * | 2019-04-12 | 2023-01-18 | The Trustees of The University of Pennsylvania | Compositions and methods comprising a high affinity chimeric antigen receptor (car) with cross-reactivity to clinically-relevant egfr mutated proteins |
| JP2022526187A (ja) * | 2019-04-12 | 2022-05-23 | エモリー ユニバーシティー | 造血細胞の細胞傷害性を促進するための組成物及び方法 |
| US20230144237A1 (en) * | 2019-04-22 | 2023-05-11 | Nanjing Legend Biotech Co., Ltd. | Engineered cells and uses thereof |
| AU2020265679A1 (en) | 2019-04-30 | 2021-12-23 | Senti Biosciences, Inc. | Chimeric receptors and methods of use thereof |
| EP3966242A1 (en) * | 2019-05-04 | 2022-03-16 | Inhibrx, Inc. | Cd123-binding polypeptides and uses thereof |
| WO2020232127A1 (en) * | 2019-05-13 | 2020-11-19 | The Research Foundation For The State University Of New York | Compositions and methods to block and bind ccr2 to modulate cellular function |
| CN110251695B (zh) * | 2019-07-10 | 2021-12-21 | 莎穆(上海)生物科技有限公司 | 一种靶向her2的放射性配合物及其制备方法和应用 |
| EP4004035A4 (en) | 2019-07-30 | 2023-06-28 | Kindred Biosciences, Inc. | Parvovirus antibodies for veterinary use |
| WO2021041725A1 (en) * | 2019-08-27 | 2021-03-04 | The Trustees Of The Univeristy Of Pennsylvania | SYNTHETIC CARS TO TREAT IL13Rα2 POSITIVE HUMAN AND CANINE TUMORS |
| KR102329720B1 (ko) | 2019-08-30 | 2021-11-23 | 한국과학기술연구원 | 단백질 키나아제 저해 활성을 갖는 신규한 피리미도[4,5-d]피리미딘-2-온 유도체 |
| WO2021044439A1 (en) * | 2019-09-08 | 2021-03-11 | Immunoadaptive Cell Therapy Pvt Ltd. | Inducible cytokine signals & methods for immunotherapy |
| EP4028413A1 (en) | 2019-09-10 | 2022-07-20 | Obsidian Therapeutics, Inc. | Ca2-il15 fusion proteins for tunable regulation |
| BR112022004458A2 (pt) * | 2019-09-12 | 2022-05-31 | Tcr2 Therapeutics Inc | Composições e métodos para reprogramação de tcr usando proteínas de fusão |
| CN110964113B (zh) * | 2019-12-24 | 2021-09-03 | 北京纽安博生物技术有限公司 | 介导结合免疫球蛋白的单域抗体、由其构建的双功能抗体及其应用 |
| CN110964122B (zh) * | 2019-12-24 | 2022-04-15 | 南京北恒生物科技有限公司 | T细胞受体融合蛋白及其用途 |
| CN116034113A (zh) * | 2019-12-30 | 2023-04-28 | 华夏英泰(北京)生物技术有限公司 | 一种增强型t细胞受体star及其应用 |
| CN113122628B (zh) * | 2019-12-30 | 2023-08-11 | 广州医科大学附属第三医院(广州重症孕产妇救治中心、广州柔济医院) | Clec5a基因作为标志物在子宫内膜癌中诊断及治疗的应用 |
| CN111154889B (zh) * | 2020-01-16 | 2021-08-03 | 广西扬翔股份有限公司 | 一种与猪体重相关的snp分子标记及其应用和获取方法 |
| WO2021168274A1 (en) | 2020-02-21 | 2021-08-26 | Silverback Therapeutics, Inc. | Nectin-4 antibody conjugates and uses thereof |
| US20210277149A1 (en) * | 2020-03-06 | 2021-09-09 | Mustang Bio, Inc. | Anti-idiotype antibodies and methods of using the same |
| CN111320703A (zh) * | 2020-03-11 | 2020-06-23 | 北京双赢科创生物科技有限公司 | 靶向cd22的嵌合抗原受体及其应用 |
| EP4118225A1 (en) | 2020-03-13 | 2023-01-18 | The Johns Hopkins University | Exosomal nucleic acid vaccine modularly configured to harness multiple antigen presentation mechanisms |
| EP4121079A4 (en) | 2020-03-16 | 2024-10-30 | Angeles Therapeutics, Inc. | NEW ANTIGEN-BINDING DOMAINS AND SYNTHETIC ANTIGEN RECEPTORS |
| GB202004371D0 (en) * | 2020-03-26 | 2020-05-13 | Glaxosmithkline Ip Dev Ltd | CAR constructs |
| CA3177181A1 (en) * | 2020-03-27 | 2021-09-30 | 2Seventy Bio, Inc. | T cell receptors |
| GB202007532D0 (en) * | 2020-05-20 | 2020-07-01 | Alchemab Therapeutics Ltd | Polypeptides |
| CN116157151A (zh) | 2020-05-26 | 2023-05-23 | 真和制药有限公司 | 通过阻断半乳凝素-3治疗炎性疾病的方法 |
| US20230293691A1 (en) * | 2020-06-11 | 2023-09-21 | Innovative Cellular Therapeutics Holdings, Ltd. | Cell/gene therapies targeting mage-a4 peptide |
| CN113801238A (zh) * | 2020-06-11 | 2021-12-17 | 南京北恒生物科技有限公司 | 表达nk抑制性分子的工程化免疫细胞及其用途 |
| CN111826400A (zh) * | 2020-07-21 | 2020-10-27 | 中科宝承生物医学科技有限公司 | 一种双特异性抗体nk细胞制备方法及其细胞和应用 |
| GB202011993D0 (en) | 2020-07-31 | 2020-09-16 | Adc Therapeutics Sa | ANTI-IL 13Ra2 antibodies |
| CN112285347B (zh) * | 2020-09-30 | 2023-12-22 | 西北农林科技大学 | 一种猪血清样中病原抗体elisa检测试剂盒 |
| US20240002536A1 (en) * | 2020-11-09 | 2024-01-04 | The General Hospital Corporation | Antibodies and Single-Chain Variable Region Proteins Recognizing Click Products |
| CN112458094B (zh) * | 2020-11-16 | 2023-05-05 | 武汉华美生物工程有限公司 | Gprc5d蛋白的制备方法和应用 |
| AU2021410077A1 (en) * | 2020-12-22 | 2023-07-20 | Neogene Therapeutics B.V. | Peptide markers to track genetically engineered cells |
| JP2024503507A (ja) * | 2021-01-20 | 2024-01-25 | インエイトバイオ,インコーポレイテッド | 多価クロロトキシンキメラ抗原受容体 |
| CN116848131A (zh) * | 2021-02-09 | 2023-10-03 | 南京传奇生物科技有限公司 | 工程化细胞及其用途 |
| IL305188A (en) * | 2021-02-16 | 2023-10-01 | Childrens Health Care D/B/A Childrens Minnesota | Methods for treating B-ALL by administering a pre-BCR complex antagonist |
| EP4297769A2 (en) * | 2021-02-19 | 2024-01-03 | Preet M. Chaudhary | Single-chain and multi-chain synthetic antigen receptors for diverse immune cells |
| CN114957481A (zh) * | 2021-02-25 | 2022-08-30 | 华夏英泰(北京)生物技术有限公司 | 针对cd19和cd22的双靶点star |
| CN117480247A (zh) * | 2021-04-15 | 2024-01-30 | 恺兴生命科技(上海)有限公司 | 嵌合t细胞受体及其应用 |
| CN115232797A (zh) * | 2021-04-23 | 2022-10-25 | 南京北恒生物科技有限公司 | 工程化免疫细胞及其用途 |
| WO2022228771A1 (en) * | 2021-04-26 | 2022-11-03 | Easemedcontrol R & D Gmbh & Co Kg | Identification of b-cell and t-cell receptor chains for diagnosis and treatment of inflammatory diseases |
| JP2024519869A (ja) * | 2021-05-19 | 2024-05-21 | セレディット エルエルシー | 二重特異性キメラ抗原受容体、及びそれを発現する遺伝子操作された免疫細胞 |
| CN117897411A (zh) * | 2021-06-30 | 2024-04-16 | 华夏英泰(北京)生物技术有限公司 | 一种多靶点合成t细胞受体抗原/抗体受体及其应用 |
| AU2022310862A1 (en) | 2021-07-14 | 2024-02-01 | Regeneron Pharmaceuticals, Inc. | Engineered t cell receptors fused to binding domains from antibodies |
| CN113671187A (zh) * | 2021-08-12 | 2021-11-19 | 上海交通大学医学院附属上海儿童医学中心 | 一种用于检测mycn蛋白的ihc检测试剂盒 |
| US11970548B2 (en) * | 2021-08-27 | 2024-04-30 | Innovative Cellular Therapeutics Holdings, Ltd. | Nanobody target GCC and uses in chimeric antigen receptor cell therapy |
| WO2023056194A2 (en) * | 2021-09-29 | 2023-04-06 | Chimera Bioengineering, Inc. | Compositions and methods for anti-tnmuc1 gold car t-cells |
| US20250242023A1 (en) * | 2021-10-22 | 2025-07-31 | Regents Of The University Of Minnesota | Genetically engineered t cell receptors |
| IL312204A (en) | 2021-10-28 | 2024-06-01 | Lyell Immunopharma Inc | Methods for culturing cells expressing ror1-binding protein |
| CN114044823B (zh) * | 2021-11-05 | 2022-07-05 | 深圳市人民医院 | 靶向钙粘蛋白17的纳米抗体及其应用 |
| WO2023215725A1 (en) * | 2022-05-02 | 2023-11-09 | Fred Hutchinson Cancer Center | Compositions and methods for cellular immunotherapy |
| CN116063468A (zh) * | 2022-08-30 | 2023-05-05 | 武汉班科生物技术有限公司 | 中和呼吸道合胞病毒的c-型单域抗体及应用 |
| WO2024064958A1 (en) | 2022-09-23 | 2024-03-28 | Lyell Immunopharma, Inc. | Methods for culturing nr4a-deficient cells |
| WO2024064952A1 (en) | 2022-09-23 | 2024-03-28 | Lyell Immunopharma, Inc. | Methods for culturing nr4a-deficient cells overexpressing c-jun |
| WO2024077174A1 (en) | 2022-10-05 | 2024-04-11 | Lyell Immunopharma, Inc. | Methods for culturing nr4a-deficient cells |
| WO2025010111A1 (en) | 2023-07-05 | 2025-01-09 | Nanotein Technologies, Inc. | Cell signaling complexes and uses thereof |
| US12473529B2 (en) | 2023-07-18 | 2025-11-18 | Nanotein Technologies, Inc. | Reagents, reagent kits, and culture media for activating and expanding immune cells and uses thereof |
| WO2025217398A1 (en) | 2024-04-10 | 2025-10-16 | Lyell Immunopharma, Inc. | Methods for culturing cells with improved culture medium |
| EP4635976A1 (en) * | 2024-04-19 | 2025-10-22 | Medigene Immunotherapies GmbH | Constant uni-tabs |
| WO2025219541A1 (en) * | 2024-04-19 | 2025-10-23 | Medigene Immunotherapies Gmbh | Constant uni-tabs |
| WO2025245381A1 (en) | 2024-05-23 | 2025-11-27 | The Trustrees Of Dartmouth College | Methods and compositions for enhancing the persistence of car expressing tregs in the cns and other tissues |
| WO2025245417A1 (en) * | 2024-05-23 | 2025-11-27 | Yale University | Chimeric antigen receptors (cars) targeting met |
Family Cites Families (165)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4708871A (en) | 1983-03-08 | 1987-11-24 | Commonwealth Serum Laboratories Commission | Antigenically active amino acid sequences |
| US5906936A (en) | 1988-05-04 | 1999-05-25 | Yeda Research And Development Co. Ltd. | Endowing lymphocytes with antibody specificity |
| IL86278A (en) | 1988-05-04 | 2003-06-24 | Yeda Res & Dev | Endowing cells with antibody specificity using chimeric t cell receptor |
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| US5199942A (en) | 1991-06-07 | 1993-04-06 | Immunex Corporation | Method for improving autologous transplantation |
| IL104570A0 (en) | 1992-03-18 | 1993-05-13 | Yeda Res & Dev | Chimeric genes and cells transformed therewith |
| US8211422B2 (en) | 1992-03-18 | 2012-07-03 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Chimeric receptor genes and cells transformed therewith |
| EP0985039B1 (en) | 1997-06-12 | 2008-02-20 | Novartis International Pharmaceutical Ltd. | Artificial antibody polypeptides |
| TWI224995B (en) | 1998-03-19 | 2004-12-11 | Ciba Sc Holding Ag | Stabilization of wood substrates |
| US7754208B2 (en) | 2001-01-17 | 2010-07-13 | Trubion Pharmaceuticals, Inc. | Binding domain-immunoglobulin fusion proteins |
| MXPA03009797A (es) | 2001-04-26 | 2004-01-29 | Biogen Inc | ANTICUERPOS PARA BLOQUEO DE PROTEiNA CRIPTO Y USO DE LOS MISMOS. |
| ATE290020T1 (de) | 2001-08-31 | 2005-03-15 | Avidex Ltd | Löslicher t zell rezeptor |
| JP2005527474A (ja) | 2001-09-20 | 2005-09-15 | コーネル リサーチ ファンデーション インコーポレーテッド | 前立腺特異的膜抗原に特異的な結合剤を用いて、皮膚障害を治療するかまたは防止するための方法および組成物 |
| AU2002363939A1 (en) | 2001-11-20 | 2003-06-10 | Seattle Genetics, Inc. | Treatment of immunological disorders using anti-cd30 antibodies |
| US6992176B2 (en) | 2002-02-13 | 2006-01-31 | Technion Research & Development Foundation Ltd. | Antibody having a T-cell receptor-like specificity, yet higher affinity, and the use of same in the detection and treatment of cancer, viral infection and autoimmune disease |
| CA2476625A1 (en) | 2002-02-20 | 2003-08-28 | Dyax Corp. | Mhc-peptide complex binding ligands |
| EP1549748B1 (en) | 2002-10-09 | 2014-10-01 | Immunocore Ltd. | Single chain recombinant t cell receptors |
| GB0304068D0 (en) * | 2003-02-22 | 2003-03-26 | Avidex Ltd | Substances |
| CU23403A1 (es) | 2003-04-23 | 2009-08-04 | Centro Inmunologia Molecular | Anticuerpos recombinantes y fragmentos que reconocen el gangliósido n-glicolil gm3 y su uso para diagnóstico y tratamiento de tumores |
| US7709610B2 (en) | 2003-05-08 | 2010-05-04 | Facet Biotech Corporation | Therapeutic use of anti-CS1 antibodies |
| AR044388A1 (es) | 2003-05-20 | 2005-09-07 | Applied Molecular Evolution | Moleculas de union a cd20 |
| ATE408684T1 (de) | 2004-05-19 | 2008-10-15 | Medigene Ltd | Verfahren zur verbesserung von t-zellrezeptoren |
| WO2005113595A2 (en) | 2004-05-19 | 2005-12-01 | Avidex Ltd | High affinity ny-eso t cell receptor |
| EP1765988B1 (en) | 2004-05-27 | 2017-09-20 | The Trustees of The University of Pennsylvania | Novel artificial antigen presenting cells and uses therefor |
| ES2382627T3 (es) | 2004-06-29 | 2012-06-12 | B.R.A.H.M.S Gmbh | Nuevos anticuerpos monoclonales estimuladores o bloqueadores de la tiroides, secuencias peptídicas que corresponden a sus regiones variables, y sus usos en medicina diagnóstica, preventiva y terapéutica |
| WO2006039418A2 (en) | 2004-09-30 | 2006-04-13 | Medarex, Inc. | Human monoclonal antibodies to fc gamma receptor ii (cd32) |
| AU2005291039A1 (en) * | 2004-10-01 | 2006-04-13 | Avidex Ltd. | T-cell receptors containing a non-native disulfide interchain bond linked to therapeutic agents |
| WO2006071441A2 (en) | 2004-11-30 | 2006-07-06 | Curagen Corporation | Antibodies directed to gpnmb and uses thereof |
| KR20070100346A (ko) | 2005-01-05 | 2007-10-10 | 바이오겐 아이덱 엠에이 인코포레이티드 | 크립토 결합 분자 |
| DOP2006000029A (es) | 2005-02-07 | 2006-08-15 | Genentech Inc | Antibody variants and uses thereof. (variantes de un anticuerpo y usos de las mismas) |
| WO2007002223A2 (en) | 2005-06-20 | 2007-01-04 | Medarex, Inc. | Cd19 antibodies and their uses |
| SG177194A1 (en) | 2005-12-08 | 2012-01-30 | Medarex Inc | Human monoclonal antibodies to protein tyrosine kinase 7 (ptk7) and methods for using anti-ptk7 antibodies |
| HRP20120701T1 (hr) | 2005-12-08 | 2012-10-31 | Medarex, Inc. | Humana monoklonska protutijela protiv fukozil-gm1 i postupci za uporabu antifukozil-gm1 |
| PT1966245E (pt) | 2005-12-30 | 2011-08-31 | Merck Patent Gmbh | Anticorpos anti-cd19 com imunogenicidade reduzida |
| US20080131428A1 (en) | 2006-02-24 | 2008-06-05 | Arius Research, Inc. | Cytotoxicity mediation of cells evidencing surface expression of TROP-2 |
| EP2650306A1 (en) | 2006-03-06 | 2013-10-16 | Aeres Biomedical Limited | Humanized Anti-CD22 antibodies and their use in treatment of oncology, transplantation and autoimmune disease |
| HRP20140172T1 (hr) | 2006-05-30 | 2014-03-28 | Genentech, Inc. | Protutijela i imunokonjugati kao i njihove uporabe |
| KR101456728B1 (ko) | 2006-09-08 | 2014-10-31 | 메디뮨 엘엘씨 | 인간화 항-cd19 항체, 및 이것의 종양학, 이식 및 자가면역 질환의 치료에서의 용도 |
| US20080280890A1 (en) | 2007-02-22 | 2008-11-13 | Ghanshyam Patil | Hydroxylamine compounds and methods of their use |
| EP2014302A1 (en) | 2007-07-12 | 2009-01-14 | Institut Curie | An antibody specific for the Tn antigen for the treatment of cancer |
| EP2186825A1 (en) * | 2008-11-13 | 2010-05-19 | Max-Delbrück-Centrum für Molekulare Medizin (MDC) | Human-derived T cell receptors |
| UA109633C2 (uk) | 2008-12-09 | 2015-09-25 | Антитіло людини проти тканинного фактора | |
| CN102439163A (zh) | 2009-02-16 | 2012-05-02 | 拜奥雷克斯治疗公司 | 人源化抗cd20抗体及使用方法 |
| WO2010095031A2 (en) | 2009-02-23 | 2010-08-26 | Glenmark Pharmaceuticals S.A. | Humanized antibodies that bind to cd19 and their uses |
| WO2010107658A2 (en) | 2009-03-16 | 2010-09-23 | Vallera Daniel A | Methods and compositions for bi-specific targeting of cd19/cd22 |
| SG10201401604VA (en) | 2009-04-20 | 2014-08-28 | Oxford Biotherapeutics Ltd | Antibodies Specific To Cadherin-17 |
| WO2011009090A1 (en) | 2009-07-16 | 2011-01-20 | Xoma Technology Ltd. | Antibodies to high molecular weight melanoma associated antigen |
| NZ598791A (en) | 2009-10-23 | 2014-05-30 | Millennium Pharm Inc | Anti-gcc antibody molecules and related compositions and methods |
| WO2011059836A2 (en) | 2009-10-29 | 2011-05-19 | Trustees Of Dartmouth College | T cell receptor-deficient t cell compositions |
| US20120269814A1 (en) | 2009-11-10 | 2012-10-25 | Amgen Inc. | Anti-c mpl antibodies |
| US9169328B2 (en) | 2010-03-26 | 2015-10-27 | Memorial Sloan Kettering Cancer Center | Antibodies to MUC16 and methods of use thereof |
| ES2811065T3 (es) | 2010-05-11 | 2021-03-10 | Hutchinson Fred Cancer Res | Variantes de clorotoxina, conjugados y métodos para su utilización |
| AU2011254557B2 (en) | 2010-05-20 | 2015-09-03 | Ablynx Nv | Biological materials related to HER3 |
| EP2409993A1 (en) | 2010-07-19 | 2012-01-25 | International-Drug-Development-Biotech | Anti-CD19 antibody having ADCC function with improved glycosylation profile |
| WO2012012695A2 (en) | 2010-07-23 | 2012-01-26 | Fred Hutchinson Cancer Research Center | A method for the treatment of obesity |
| AR082641A1 (es) | 2010-09-07 | 2012-12-19 | Imclone Llc | Composiciones de anticuerpo anti-vegfr-3 |
| EP2621953B1 (en) | 2010-09-30 | 2017-04-05 | Ablynx N.V. | Biological materials related to c-met |
| UA112062C2 (uk) | 2010-10-04 | 2016-07-25 | Бьорінгер Інгельхайм Інтернаціональ Гмбх | Cd33-зв'язувальний агент |
| WO2012058460A2 (en) | 2010-10-27 | 2012-05-03 | Baylor College Of Medicine | Chimeric cd27 receptors for redirecting t cells to cd70-positive malignancies |
| EA201391449A1 (ru) | 2011-04-01 | 2014-03-31 | Мемориал Слоан-Кеттеринг Кэнсер Сентер | Антитела против пептидов цитозоля |
| US20140105915A1 (en) | 2011-05-27 | 2014-04-17 | Glaxo Group Limited | Bcma (cd269/tnfrsf17) - binding proteins |
| CN103717236A (zh) | 2011-06-08 | 2014-04-09 | 加利福尼亚大学董事会 | 治疗肺癌和前列腺癌的抗-cd22抗原结合分子 |
| WO2013019730A1 (en) | 2011-07-29 | 2013-02-07 | The Washington University | Antibodies to tip-1 and grp78 |
| KR20200058583A (ko) | 2011-08-16 | 2020-05-27 | 모르포시스 아게 | 항-cd19 항체 및 질소 머스타드를 사용한 조합 요법 |
| CN107058101B (zh) | 2011-10-17 | 2021-06-01 | 麻省理工学院 | 细胞内传递 |
| TWI679212B (zh) | 2011-11-15 | 2019-12-11 | 美商安進股份有限公司 | 針對bcma之e3以及cd3的結合分子 |
| US20130302274A1 (en) | 2011-11-25 | 2013-11-14 | Roche Glycart Ag | Combination therapy |
| ES2812849T3 (es) | 2012-02-24 | 2021-03-18 | Abbvie Stemcentrx Llc | Anticuerpos anti-DLL3 y procedimientos de utilización de los mismos |
| WO2013130565A1 (en) | 2012-02-29 | 2013-09-06 | The Brigham And Women's Hosptial, Inc. | Neutralizing antibody for epstein barr virus associated disease |
| HK1206283A1 (en) | 2012-03-12 | 2016-01-08 | Medimmune, Llc | Treatment of multiple sclerosis with anti-cd19 antibody |
| US9163090B2 (en) | 2012-05-07 | 2015-10-20 | Cellerant Therapeutics, Inc. | Antibodies specific for CLL-1 |
| WO2013167153A1 (en) | 2012-05-09 | 2013-11-14 | Ganymed Pharmaceuticals Ag | Antibodies useful in cancer diagnosis |
| US20130309223A1 (en) | 2012-05-18 | 2013-11-21 | Seattle Genetics, Inc. | CD33 Antibodies And Use Of Same To Treat Cancer |
| DK3473707T3 (da) | 2012-05-25 | 2025-03-17 | Cellectis | Fremgangsmåder til engineering af allogen og immunsuppressiv resistent t-celle til immunoterapi |
| WO2014039513A2 (en) | 2012-09-04 | 2014-03-13 | The Trustees Of The University Of Pennsylvania | Inhibition of diacylglycerol kinase to augment adoptive t cell transfer |
| US9416190B2 (en) | 2012-09-27 | 2016-08-16 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Mesothelin antibodies and methods for eliciting potent antitumor activity |
| US9695228B2 (en) | 2012-11-21 | 2017-07-04 | Janssen Biotech, Inc. | EGFR and c-Met fibronectin type III domain binding molecules |
| EP2738180A1 (en) | 2012-11-30 | 2014-06-04 | Molecular Partners AG | Binding proteins comprising at least two binding domains against HER2. |
| WO2014089354A1 (en) | 2012-12-07 | 2014-06-12 | The Regents Of The University Of California | Cd138-targeted interferon demonstrates potent apoptotic and anti-tumor activities |
| ES2871816T3 (es) | 2012-12-27 | 2021-11-02 | Sanofi Sa | Anticuerpos anti-LAMP1 y conjugados anticuerpo-fármaco, y usos de los mismos |
| US9920121B2 (en) | 2013-01-25 | 2018-03-20 | Amgen Inc. | Antibodies targeting CDH19 for melanoma |
| MY175869A (en) | 2013-02-26 | 2020-07-14 | Memorial Sloan Kettering Cancer Center | Compositions and methods for immunotherapy |
| CN105407914A (zh) | 2013-03-05 | 2016-03-16 | 贝勒医学院 | T淋巴细胞中类肝素酶的表达 |
| WO2014138704A1 (en) | 2013-03-07 | 2014-09-12 | Baylor College Of Medicine | Targeting cd138 in cancer |
| AU2014249192B2 (en) | 2013-03-11 | 2017-12-21 | The Regents Of The University Of Michigan | BET bromodomain inhibitors and therapeutic methods using the same |
| EP2970492B1 (en) | 2013-03-15 | 2019-05-08 | Wake Forest University Health Sciences | Antibodies against human and canine il-13ra2 |
| UY35468A (es) | 2013-03-16 | 2014-10-31 | Novartis Ag | Tratamiento de cáncer utilizando un receptor quimérico de antígeno anti-cd19 |
| US9790282B2 (en) | 2013-03-25 | 2017-10-17 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Anti-CD276 polypeptides, proteins, and chimeric antigen receptors |
| CN104140974B (zh) | 2013-05-08 | 2017-09-29 | 科济生物医药(上海)有限公司 | 编码gpc‑3嵌合抗原受体蛋白的核酸及表达gpc‑3嵌合抗原受体蛋白的t淋巴细胞 |
| ES2828982T3 (es) | 2013-05-14 | 2021-05-28 | Univ Texas | Aplicación humana de células t de receptor de antígeno quimérico (car) diseñadas |
| WO2014190273A1 (en) | 2013-05-24 | 2014-11-27 | Board Of Regents, The University Of Texas System | Chimeric antigen receptor-targeting monoclonal antibodies |
| DK3004338T3 (en) | 2013-05-31 | 2019-04-08 | Cellectis Sa | LAGLIDADG HOMING ENDONUCLEASE DIVERSE T-CELL RECEPTOR ALPHA GENET AND APPLICATIONS THEREOF |
| GB201313377D0 (en) | 2013-07-26 | 2013-09-11 | Adaptimmune Ltd | T cell receptors |
| AU2014296059B2 (en) | 2013-08-02 | 2020-12-10 | The Regents Of The University Of California | Engineering antiviral T cell immunity through stem cells and chimeric antigen receptors |
| EP2839842A1 (en) | 2013-08-23 | 2015-02-25 | MacroGenics, Inc. | Bi-specific monovalent diabodies that are capable of binding CD123 and CD3 and uses thereof |
| EP2840091A1 (en) | 2013-08-23 | 2015-02-25 | MacroGenics, Inc. | Bi-specific diabodies that are capable of binding gpA33 and CD3 and uses thereof |
| GB201317929D0 (en) | 2013-10-10 | 2013-11-27 | Ucl Business Plc | Chimeric antigen receptor |
| KR102357968B1 (ko) | 2013-10-15 | 2022-02-03 | 더 스크립스 리서치 인스티튜트 | 키메라 항원 수용체 t 세포 스위치 및 이의 용도 |
| US10144770B2 (en) | 2013-10-17 | 2018-12-04 | National University Of Singapore | Chimeric receptors and uses thereof in immune therapy |
| WO2015077789A2 (en) | 2013-11-25 | 2015-05-28 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Chimeric antigen receptors to control hiv infection |
| EP3074025A1 (en) | 2013-11-27 | 2016-10-05 | Baylor College Of Medicine | Csgp4-specific chimeric antigen receptor for cancer |
| AU2014362238A1 (en) | 2013-12-13 | 2016-06-09 | Genentech, Inc. | Anti-CD33 antibodies and immunoconjugates |
| JPWO2015108203A1 (ja) | 2014-01-15 | 2017-03-23 | 株式会社オーダーメードメディカルリサーチ | 抗slc6a6抗体を用いたがん治療用医薬組成物 |
| ES2963718T3 (es) | 2014-01-21 | 2024-04-01 | Novartis Ag | Capacidad presentadora de antígenos de células CAR-T potenciada mediante introducción conjunta de moléculas co-estimuladoras |
| US20170145108A1 (en) | 2014-02-05 | 2017-05-25 | The University Of Chicago | Chimeric antigen receptors recognizing cancer-specific tn glycopeptide variants |
| GB201403875D0 (en) | 2014-03-05 | 2014-04-16 | Cantargia Ab | Novel antibodies and uses thereof |
| EP3125934B1 (en) | 2014-03-05 | 2019-10-23 | UCL Business Plc. | Chimeric antigen receptor (car) with antigen binding domains to the t cell receptor beta constant region |
| WO2015142675A2 (en) | 2014-03-15 | 2015-09-24 | Novartis Ag | Treatment of cancer using chimeric antigen receptor |
| DK3708579T3 (da) | 2014-04-01 | 2024-07-22 | Biontech Cell & Gene Therapies Gmbh | Claudin-6-specifikke immunreceptorer og t-celleepitoper |
| GB201406767D0 (en) | 2014-04-15 | 2014-05-28 | Cancer Rec Tech Ltd | Humanized anti-Tn-MUC1 antibodies anf their conjugates |
| SMT202100700T1 (it) | 2014-04-25 | 2022-01-10 | 2Seventy Bio Inc | Recettori antigenici chimerici con promotore mnd |
| CN107074929B (zh) | 2014-05-02 | 2021-09-03 | 宾夕法尼亚大学董事会 | 嵌合自身抗体受体t细胞的组合物和方法 |
| EP2944652A1 (en) | 2014-05-13 | 2015-11-18 | Technische Universität München | Glypican-3-specific T-cell receptors and their uses for immunotherapy of hepatocellular carcinoma |
| WO2015184228A1 (en) * | 2014-05-29 | 2015-12-03 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Anti-human papillomavirus 16 e7 t cell receptors |
| US9212225B1 (en) | 2014-07-01 | 2015-12-15 | Amphivena Therapeutics, Inc. | Bispecific CD33 and CD3 binding proteins |
| SG10201913765YA (en) | 2014-07-21 | 2020-03-30 | Novartis Ag | Treatment of cancer using a cd33 chimeric antigen receptor |
| JP7054622B2 (ja) | 2014-07-21 | 2022-04-14 | ノバルティス アーゲー | ヒト化抗bcmaキメラ抗原受容体を使用した癌の処置 |
| AR101669A1 (es) | 2014-07-31 | 2017-01-04 | Amgen Res Munich Gmbh | Constructos de anticuerpos para cdh19 y cd3 |
| WO2016022400A1 (en) | 2014-08-04 | 2016-02-11 | Fred Hutchinson Cancer Research Center | T cell immunotherapy specific for wt-1 |
| MA40513A (fr) | 2014-08-12 | 2017-06-21 | Novartis Ag | Conjugués médicament-anticorps anti-cdh6 |
| JP6919118B2 (ja) | 2014-08-14 | 2021-08-18 | ノバルティス アーゲー | GFRα−4キメラ抗原受容体を用いる癌の治療 |
| CA2958757C (en) | 2014-08-19 | 2021-04-27 | Miltenyi Biotec Gmbh | Chimeric antigen receptor specific for ssea4 antigen |
| EP2990416B1 (en) | 2014-08-29 | 2018-06-20 | GEMoaB Monoclonals GmbH | Universal chimeric antigen receptor expressing immune cells for targeting of diverse multiple antigens and method of manufacturing the same and use of the same for treatment of cancer, infections and autoimmune disorders |
| US10093746B2 (en) | 2014-09-04 | 2018-10-09 | The Trustees Of The University Of Pennsylvania | Glypican-3 antibody and uses thereof |
| JO3568B1 (ar) | 2014-09-05 | 2020-07-05 | Janssen Pharmaceutica Nv | عوامل ربط cd123 واستخداماتها |
| MX2017003062A (es) | 2014-09-09 | 2017-12-14 | Unum Therapeutics | Receptores quimericos y usos de los mismos en terapia inmune. |
| CR20170095A (es) | 2014-09-12 | 2017-07-19 | Genentech Inc | Anticuerpos anti-cll-1 e inmunoconjugados referencias recíprocas con solicitudes relacionadas |
| RU2017113134A (ru) | 2014-09-19 | 2018-10-19 | Регенерон Фармасьютикалз, Инк. | Химерные антигенные рецепторы |
| WO2016049459A1 (en) | 2014-09-26 | 2016-03-31 | Baylor College Of Medicine | Glypican-3 specific chimeric antigen receptors for adoptive immunotherapy |
| CA2965521A1 (en) | 2014-10-31 | 2016-05-06 | Baylor College Of Medicine | Survivin specific t-cell receptor targeting tumor but not t cells |
| US10011657B2 (en) | 2014-10-31 | 2018-07-03 | Abbvie Biotherapeutics Inc. | Anti-CS1 antibodies and antibody drug conjugates |
| EP3699198B1 (en) | 2014-11-17 | 2025-03-26 | Regeneron Pharmaceuticals, Inc. | Methods for tumor treatment using cd3xcd20 bispecific antibody |
| JP6753851B2 (ja) | 2014-12-05 | 2020-09-09 | メモリアル スローン ケタリング キャンサー センター | Gタンパク質共役受容体を標的化する抗体および使用の方法 |
| HUE053995T2 (hu) | 2014-12-05 | 2021-08-30 | Memorial Sloan Kettering Cancer Center | B-sejt-érési antigént célzó antitestek és alkalmazási eljárások |
| ES2899779T3 (es) | 2014-12-05 | 2022-03-14 | Memorial Sloan Kettering Cancer Center | Receptores antigénicos quiméricos dirigidos a receptor acoplado a proteína G y usos de los mismos |
| CA2970466A1 (en) | 2014-12-12 | 2016-06-16 | Bluebird Bio, Inc. | Bcma chimeric antigen receptors |
| CN114107212A (zh) | 2014-12-24 | 2022-03-01 | 奥托路斯有限公司 | 细胞 |
| TN2018000324A1 (en) | 2015-01-23 | 2020-01-16 | Sanofi Sa | ANTl-CD3 ANTIBODIES, ANTl-CD123 ANTIBODIES AND BISPECIFIC ANTIBODIES SPECIFICALLY BINDING TO CD3 AND/OR CD123 |
| AU2016212158B2 (en) | 2015-01-26 | 2021-06-03 | Allogene Therapeutics, Inc. | mAb-driven chimeric antigen receptor systems for sorting/depleting engineered immune cells |
| WO2016126488A1 (en) | 2015-02-02 | 2016-08-11 | Sea Lane Biotechnologies, Llc | Anti-surrogate light chain antibodies |
| WO2016154047A2 (en) | 2015-03-20 | 2016-09-29 | Memorial Sloan-Kettering Cancer Center | Monoclonal antigen-binding proteins to intracellular oncogene products |
| US11136401B2 (en) | 2015-03-27 | 2021-10-05 | University Of Southern California | Car t-cell therapy directed to LHR for the treatment of solid tumors |
| BR112017020750A2 (pt) | 2015-03-27 | 2018-06-26 | Harvard College | células t modificadas e métodos de produção e utilização das mesmas |
| RU2706582C2 (ru) | 2015-04-13 | 2019-11-19 | Пфайзер Инк. | Химерные антигенные рецепторы, нацеленные на антиген созревания B-клеток |
| EP3283619B1 (en) | 2015-04-17 | 2023-04-05 | Novartis AG | Methods for improving the efficacy and expansion of chimeric antigen receptor-expressing cells |
| EP3288568A4 (en) | 2015-04-30 | 2019-01-02 | University of Southern California | Secretory tnt car cell immunotherapy |
| JP7366518B2 (ja) | 2015-05-06 | 2023-10-23 | ヤンセン バイオテツク,インコーポレーテツド | 前立腺特異的膜抗原結合フィブロネクチンiii型ドメイン |
| DK3611192T3 (da) | 2015-05-13 | 2025-06-10 | Ablynx Nv | T-celle-rekrutterende polypeptider baseret på tcr-alfa/beta-reaktivitet |
| EP3466967A1 (en) * | 2015-05-18 | 2019-04-10 | TCR2 Therapeutics Inc. | Compositions and methods for tcr reprogramming using fusion proteins |
| US9422547B1 (en) | 2015-06-09 | 2016-08-23 | Gigagen, Inc. | Recombinant fusion proteins and libraries from immune cell repertoires |
| EP3307319A4 (en) | 2015-06-09 | 2019-05-22 | Memorial Sloan Kettering Cancer Center | T CELL RECEPTOR-SIMILAR ANTIBODIES SPECIFIC TO PEPTID OF THE LATENT EBV MEMBRANE PROTEIN 2A PRESENTED BY HUMAN HLA |
| EP3340998B1 (en) | 2015-08-28 | 2023-01-11 | The Trustees of the University of Pennsylvania | Methods and compositions for cells expressing a chimeric intracellular signaling molecule |
| IL297003A (en) | 2015-09-17 | 2022-12-01 | Novartis Ag | car-t cell treatments with improved efficacy |
| PL3362470T3 (pl) | 2015-10-13 | 2022-02-21 | City Of Hope | Chimeryczne receptory antygenowe zawierające domenę chlorotoksyny |
| IL295398B2 (en) * | 2015-10-23 | 2025-01-01 | Eureka Therapeutics Inc | Antibody/T-cell receptor chimeric constructs and their uses |
| JP2018534933A (ja) | 2015-11-02 | 2018-11-29 | ヤンセン ファーマシューティカ エヌ.ベー. | 抗il1rap抗体、il1rapとcd3を結合する二重特異性抗原結合分子、及びその使用 |
| CA3018253A1 (en) | 2016-03-31 | 2017-10-05 | University Of Southern California | A highly sensitive and specific luciferase based reporter assay for antigen detection |
| US10603380B2 (en) | 2016-04-01 | 2020-03-31 | Kite Pharma, Inc. | Chimeric antigen and T cell receptors and methods of use |
| TWI761831B (zh) | 2016-04-01 | 2022-04-21 | 美商凱特製藥公司 | 嵌合抗原受體(car)和t細胞受體(tcr)及彼等之用途 |
| US12060394B2 (en) | 2016-04-28 | 2024-08-13 | The Trustees Of Dartmouth College | Nucleic acid constructs for co-expression of chimeric antigen receptor and transcription factor, cells containing and therapeutic use thereof |
| WO2017192536A1 (en) * | 2016-05-02 | 2017-11-09 | University Of Kansas | Eliminating mhc restriction from the t cell receptor as a strategy for immunotherapy |
| WO2018013993A1 (en) | 2016-07-14 | 2018-01-18 | University Of Southern California | Methods and composition for producing and using immune cells and stem cells for cell-based therapies |
| MX2019000643A (es) | 2016-07-15 | 2019-06-13 | Poseida Therapeutics Inc | Receptores de antigenos quimericos y metodos de uso. |
| EP3516068B1 (en) | 2016-09-19 | 2025-04-23 | University of Southern California | Non-radioactive cytotoxicity assays |
| AU2020204686A1 (en) | 2019-01-04 | 2021-07-22 | Marengo Therapeutics, Inc. | Anti-TCR antibody molecules and uses thereof |
-
2017
- 2017-12-02 AU AU2017366739A patent/AU2017366739B2/en active Active
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Non-Patent Citations (1)
| Title |
|---|
| Adv Drug Deliv Rev. 2012 June 1, 64(8): 756-762. 1부.* |
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