KR102132246B1 - 키메라 항원 수용체 및 이의 이용 방법 - Google Patents
키메라 항원 수용체 및 이의 이용 방법 Download PDFInfo
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- KR102132246B1 KR102132246B1 KR1020197034038A KR20197034038A KR102132246B1 KR 102132246 B1 KR102132246 B1 KR 102132246B1 KR 1020197034038 A KR1020197034038 A KR 1020197034038A KR 20197034038 A KR20197034038 A KR 20197034038A KR 102132246 B1 KR102132246 B1 KR 102132246B1
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- C—CHEMISTRY; METALLURGY
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- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
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- A—HUMAN NECESSITIES
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- A61K40/00—Cellular immunotherapy
- A61K40/10—Cellular immunotherapy characterised by the cell type used
- A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
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- A—HUMAN NECESSITIES
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- A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
- A61K40/31—Chimeric antigen receptors [CAR]
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- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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- C07K14/7051—T-cell receptor (TcR)-CD3 complex
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- C—CHEMISTRY; METALLURGY
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- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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- C—CHEMISTRY; METALLURGY
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- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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- C07K14/70575—NGF/TNF-superfamily, e.g. CD70, CD95L, CD153, CD154
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- C—CHEMISTRY; METALLURGY
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- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70578—NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
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- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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- C—CHEMISTRY; METALLURGY
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- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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- C—CHEMISTRY; METALLURGY
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- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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- C—CHEMISTRY; METALLURGY
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- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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- C—CHEMISTRY; METALLURGY
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- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
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- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
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- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
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- C07K2319/00—Fusion polypeptide
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- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
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- C—CHEMISTRY; METALLURGY
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- C07K2319/00—Fusion polypeptide
- C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
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- C07K2319/00—Fusion polypeptide
- C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
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- C—CHEMISTRY; METALLURGY
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- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
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- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
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- C12Y—ENZYMES
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- C12Y502/01—Cis-trans-Isomerases (5.2.1)
- C12Y502/01008—Peptidylprolyl isomerase (5.2.1.8), i.e. cyclophilin
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- Proteomics, Peptides & Aminoacids (AREA)
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- General Chemical & Material Sciences (AREA)
- Hematology (AREA)
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- Developmental Biology & Embryology (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1020207019131A KR102332790B1 (ko) | 2013-02-15 | 2014-02-14 | 키메라 항원 수용체 및 이의 이용 방법 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361765585P | 2013-02-15 | 2013-02-15 | |
| US61/765,585 | 2013-02-15 | ||
| PCT/US2014/016527 WO2014127261A1 (en) | 2013-02-15 | 2014-02-14 | Chimeric antigen receptor and methods of use thereof |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020157024731A Division KR102064230B1 (ko) | 2013-02-15 | 2014-02-14 | 키메라 항원 수용체 및 이의 이용 방법 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020207019131A Division KR102332790B1 (ko) | 2013-02-15 | 2014-02-14 | 키메라 항원 수용체 및 이의 이용 방법 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR20190131152A KR20190131152A (ko) | 2019-11-25 |
| KR102132246B1 true KR102132246B1 (ko) | 2020-07-09 |
Family
ID=51354582
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020197034038A Active KR102132246B1 (ko) | 2013-02-15 | 2014-02-14 | 키메라 항원 수용체 및 이의 이용 방법 |
| KR1020157024731A Active KR102064230B1 (ko) | 2013-02-15 | 2014-02-14 | 키메라 항원 수용체 및 이의 이용 방법 |
| KR1020237003986A Active KR102813881B1 (ko) | 2013-02-15 | 2014-02-14 | 키메라 항원 수용체 및 이의 이용 방법 |
| KR1020207019131A Active KR102332790B1 (ko) | 2013-02-15 | 2014-02-14 | 키메라 항원 수용체 및 이의 이용 방법 |
| KR1020217038402A Ceased KR20210147101A (ko) | 2013-02-15 | 2014-02-14 | 키메라 항원 수용체 및 이의 이용 방법 |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020157024731A Active KR102064230B1 (ko) | 2013-02-15 | 2014-02-14 | 키메라 항원 수용체 및 이의 이용 방법 |
| KR1020237003986A Active KR102813881B1 (ko) | 2013-02-15 | 2014-02-14 | 키메라 항원 수용체 및 이의 이용 방법 |
| KR1020207019131A Active KR102332790B1 (ko) | 2013-02-15 | 2014-02-14 | 키메라 항원 수용체 및 이의 이용 방법 |
| KR1020217038402A Ceased KR20210147101A (ko) | 2013-02-15 | 2014-02-14 | 키메라 항원 수용체 및 이의 이용 방법 |
Country Status (20)
| Country | Link |
|---|---|
| US (10) | US20150368342A1 (enExample) |
| EP (5) | EP2956175B1 (enExample) |
| JP (5) | JP6450690B2 (enExample) |
| KR (5) | KR102132246B1 (enExample) |
| CN (2) | CN110423282B (enExample) |
| AU (5) | AU2014216130B2 (enExample) |
| CA (1) | CA2901115A1 (enExample) |
| CY (1) | CY1122386T1 (enExample) |
| DK (2) | DK2956175T3 (enExample) |
| ES (3) | ES2758227T3 (enExample) |
| HR (1) | HRP20192123T1 (enExample) |
| HU (2) | HUE036250T2 (enExample) |
| IL (3) | IL272279B2 (enExample) |
| LT (2) | LT2956175T (enExample) |
| MX (2) | MX369545B (enExample) |
| NO (1) | NO2929995T3 (enExample) |
| PL (3) | PL2956175T3 (enExample) |
| PT (3) | PT2956175T (enExample) |
| SI (2) | SI3613439T1 (enExample) |
| WO (1) | WO2014127261A1 (enExample) |
Families Citing this family (332)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
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| WO2011119773A1 (en) | 2010-03-23 | 2011-09-29 | Roeth Jeremiah F | Vectors conditionally expressing therapeutic proteins, host cells comprising the vectors, and uses thereof |
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