TWI765875B - 新抗原辨識、製造及用途 - Google Patents
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- TWI765875B TWI765875B TW105141968A TW105141968A TWI765875B TW I765875 B TWI765875 B TW I765875B TW 105141968 A TW105141968 A TW 105141968A TW 105141968 A TW105141968 A TW 105141968A TW I765875 B TWI765875 B TW I765875B
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Abstract
本文揭示用於確定對偶基因、新抗原及疫苗組合物之系統及方法,如基於個體之腫瘤突變所確定。本文亦揭示用於自腫瘤獲得高品質測序數據之系統及方法。此外,本文闡述用於辨識多型性基因體數據中之體細胞變化之系統及方法。最後,本文闡述獨特的癌症疫苗。
Description
基於腫瘤特異性新抗原之治療性疫苗很有希望作為下一代個人化癌症免疫療法。1-3
鑒於新抗原產生之相對較大之可能性,具有高突變負荷之癌症(例如非小細胞肺癌(NSCLC)及黑色素瘤)係該療法之尤具吸引力之靶。4,5
早期證據顯示,基於新抗原之疫苗接種可引發T細胞反應6
,且在所選患者中在某些情況下新抗原靶向細胞療法可引起腫瘤消退7
。 新抗原疫苗設計之一個問題在於,存在於標的腫瘤中之許多編碼突變中之哪一者可產生「最佳」治療性新抗原,例如可引發抗腫瘤免疫性且引起腫瘤消退之抗原。 業內已提出納入基於突變之分析利用下一代測序、RNA基因表現及預測候選新抗原肽之MHC結合親和力的初始方法8
。然而,該等所提出方法可能無法對整個表位產生過程建模,該過程除基因表現及MHC結合外含有許多步驟(例如,TAP轉運、蛋白酶體裂解及/或TCR識別)9
。因此,現有方法可能具有降低的低陽性預測值(PPV)。(圖1A) 實際上,由多個組實施之對腫瘤細胞所呈遞之肽的分析已顯示,利用基因表現及MHC結合親和力預測呈遞之<5%之肽可發現於腫瘤表面MHC上10,11
(圖1B)。以下最新觀察結果進一步強化結合預測與MHC呈遞之間之此低關聯性:缺少結合限制性新抗原對於僅針對突變數量之檢查點抑制劑反應之預測準確度改良12
。 用於預測呈遞之現有方法之此低陽性預測值(PPV)呈現基於新抗原之疫苗設計之問題。若使用具有低PPV之預測來設計疫苗,則大多數患者不太可能接受治療性新抗原且極少數仍可能接受一種以上之抗原(即使假設所有經呈遞之肽皆具免疫原性)。因此,使用當前方法進行新抗原疫苗接種在大量患有腫瘤之個體中不太可能成功。(圖1C) 另外,先前方法僅利用順式作用突變產生候選新抗原,且極大地忽視了考慮neo-ORF之其他來源,包括發生在多個腫瘤類型中且引起許多基因之異常剪接13
之剪接因子之突變及產生或移除蛋白酶裂解位點之突變。 最後,腫瘤基因體及轉錄體分析之標準方法可因文庫構築、外顯子體及轉錄體捕獲、測序或數據分析中之次最佳條件而漏失產生候選新抗原之體細胞突變。同樣,標準腫瘤分析方法可不經意地促進將序列假影或生殖系多型性作為新抗原,此分別導致疫苗能力之無效使用或自體免疫性風險。
本文揭示辨識及選擇用於個人化癌症疫苗之新抗原之最佳化方法。首先,論述利用下一代測序(NGS)來最佳化用於新抗原候選者辨識之腫瘤外顯子體及轉錄體分析方法。該等方法係基於標準NGS腫瘤分析方法建立以確保新抗原候選者之最高靈敏性及特異性在所有類別之基因體變化中係高級的。其次,呈現新穎的高PPV新抗原選擇方法以克服特異性問題且確保對於疫苗納入高級之新抗原更可能引發抗腫瘤免疫性。端視實施例,該等方法包括經訓練統計回歸或非線性深度學習模型,其共同對肽-對偶基因映射以及多個長度之肽之每一對偶基因(per-allele)基序建模,從而橫跨不同長度之肽共享統計強度。非線性深度學習模型尤其可經設計及訓練以將同一細胞中之不同MHC對偶基因處理為獨立的,藉此解決使用線性模型使其彼此干擾之問題。最後,論述基於新抗原之個人化疫苗設計及製造之其他考慮因素。
相關申請案之交叉參考
本申請案主張於2015年12月16日提出申請之美國臨時申請案62/268,333、於2016年4月4日提出申請之美國臨時申請案62/317,823、於2016年8月26日提出申請之美國臨時申請案62/379,986、於2016年9月13日提出申請之美國臨時申請案62/394,074及於2016年11月23日提出申請之美國臨時申請案62/425,995的權益及優先權,該等申請案中每一者之全文出於所有目的皆以引用方式併入本文中。I. 定義
一般而言,申請專利範圍及本說明書中所用之術語意欲解釋為具有熟習此項技術者所理解之普通含義。下文定義某些術語以提供額外清晰性。在普通含義與所提供定義衝突之情形下,欲使用所提供之定義。 如本文所用術語「抗原」係誘導免疫反應之物質。 如本文所用術語「新抗原」係例如經由腫瘤細胞中之突變或腫瘤細胞所特有之轉譯後修飾具有至少一個使其不同於相應野生型親代抗原之變化的抗原。新抗原可包括多肽序列或核苷酸序列。突變可包括框移或非框移插入/缺失、誤義或無義取代、剪接位點變化、基因體重排或基因融合或產生neoORF之任何基因體或表現變化。突變亦可包括剪接變體。腫瘤細胞所特有之轉譯後修飾可包括異常磷酸化。腫瘤細胞所特有之轉譯後修飾亦可包括蛋白酶體產生之剪接抗原。參見Liepe等人,A large fraction of HLA class I ligands are proteasome-generated spliced peptides; Science. 2016年10月21日;354(6310):354-358。 如本文所用術語「腫瘤新抗原」係存在於個體之腫瘤細胞或組織中、但不存在於個體之相應正常細胞或組織中之新抗原。 如本文所用術語「基於新抗原之疫苗」係基於一或多種新抗原(例如複數種新抗原)之疫苗構築體。 如本文所用術語「候選新抗原」係產生可代表新抗原之新序列之突變或其他畸變。 如本文所用術語「編碼區」係基因之編碼蛋白質之部分。 如本文所用術語「編碼突變」係出現在編碼區中之突變。 如本文所用術語「ORF」意指開放閱讀框。 如本文所用術語「NEO-ORF」係源自突變或其他畸變(例如剪接)之腫瘤特異性ORF。 如本文所用術語「誤義突變」係引起一個胺基酸至另一者之取代之突變。 如本文所用術語「無義突變」係引起胺基酸至終止密碼子之取代之突變。 如本文所用術語「框移突變」係引起蛋白質之框架變化之突變。 如本文所用術語「插入/缺失」係插入或缺失一或多個核酸。 如本文所用術語「一致性」百分數在兩個或更多個核酸或多肽序列背景下係指如利用下文所述序列比較演算法中之一者(例如,BLASTP及BLASTN或熟習此項技術者可獲得之其他演算法)或藉由目視檢查所量測,當針對最大對應比較及比對時,兩個或更多個序列或子序列具有指定的相同核苷酸或胺基酸殘基百分比。端視應用,「一致性」百分數可存在於所比較之序列區域內(例如功能結構域內),或者存在於欲比較之兩個序列之全長內。 就序列比較而言,一個序列通常用作與測試序列進行比較之參考序列。當利用序列比較演算法時,將測試序列及參考序列輸入電腦中,必要時指定子序列坐標,並指定序列演算法程式參數。隨後,序列比較演算法將基於所指定之程式參數計算測試序列相對於參考序列之序列一致性百分數。或者,可藉由具體核苷酸之共同存在或不存在來確立序列相似性或相異性,或對於所轉譯序列藉由所選序列位置(例如,序列基序)之胺基酸來確立序列相似性或相異性。 可藉由例如以下方法實施序列之最佳比對以供比較:Smith及Waterman, Adv. Appl. Math. 2:482 (1981)之局部同源性演算法;Needleman及Wunsch, J. Mol. Biol. 48:443 (1970)之同源性比對演算法;Pearson及Lipman, Proc. Nat'l. Acad. Sci. USA 85:2444 (1988)之相似性方法之探索;該等演算法之電腦化執行方案(Wisconsin Genetics軟體包中之GAP、BESTFIT、FASTA及TFASTA,Genetics Computer Group, 575 Science Dr., Madison, Wis.)或目視檢查(通常參見Ausubel等人,參見下文)。 適於測定序列一致性及序列相似性百分數之演算法之一個實例係BLAST演算法,其闡述於Altschul等人,J. Mol. Biol. 215:403-410 (1990)中。用於實施BLAST分析之軟體可經由國家生物技術資訊中心(National Center for Biotechnology Information)公開獲得。 如本文所用術語「不終止或通讀」係使得天然終止密碼子移除之突變。 如本文所用術語「表位」係抗原之通常由抗體或T細胞受體結合之特異性部分。 如本文所用術語「免疫原性」係例如經由T細胞、B細胞或二者引發免疫反應之能力。 如本文所用術語「HLA結合親和力」、「MHC結合親和力」意指特異性抗原與特異性MHC對偶基因之間之結合親和力。 如本文所用術語「餌」係用於自樣品富集特異性DNA或RNA序列之核酸探針。 如本文所用術語「變體」係個體核酸與用作對照之參考人類基因體之間的差異。 如本文所用術語「變體呼叫」係通常根據測序之變體存在之演算法測定。 如本文所用術語「多型性」係生殖系變體,即在個體之所有帶有DNA之細胞中發現之變體。 如本文所用術語「體細胞變體」係在個體之非生殖系細胞中出現之變體。 如本文所用術語「對偶基因」係基因之形式或遺傳序列之形式或蛋白質之形式。 如本文所用術語「HLA型」係HLA基因對偶基因之補體。 如本文所用術語「無義介導之衰變」或「NMD」係因早熟的終止密碼子所致之細胞對mRNA之降解。 如本文所用術語「幹枝性突變」係起始於腫瘤形成早期且存在於腫瘤細胞之實質性部分中之突變。 如本文所用術語「亞純系突變」係起始於腫瘤形成晚期且僅存在於腫瘤細胞之亞組中之突變。 如本文所用術語「外顯子體」係編碼蛋白質之基因體之亞組。外顯子體可為基因體之集體外顯子。 如本文所用術語「邏輯式回歸」係來自統計之二進制數據之回歸模型,其中將應變數等於1之羅吉特機率(logit of the probability)建模為應變數之線性函數。 如本文所用術語「神經網路」係機器學習分類或回歸模型,其係由多個線性轉換層、隨後通常經由隨機梯度下降及反向傳播訓練之逐元素非線性組成。 如本文所用術語「蛋白質體」係由細胞、細胞之群或個體表現及/或轉譯之所有蛋白質之集合。 如本文所用術語「肽體」係由細胞表面上之MHC-I或MHC-II呈遞之所有肽之集合。肽體可指細胞或細胞集合之總稱(例如,腫瘤肽體意指包含腫瘤之所有細胞之肽體的組合)。 如本文所用術語「ELISPOT」意指酶聯免疫吸附斑點分析,其係監測人類及動物中之免疫反應之常用方法。 如本文所用術語「表位肽多聚體(dextramer)」係用於流式細胞術中之抗原特異性T細胞染色之基於聚葡萄糖之肽-MHC多聚體。 如本文所用術語「耐受性或免疫耐受性」係針對一或多種抗原(例如自身抗原)之免疫非反應性之狀態。 如本文所用術語「中樞耐受性」係藉由缺失自身反應性T細胞純系或藉由促使自身反應性T細胞純系分化成免疫抑制調控T細胞(Treg)而在胸腺中受影響之耐受性。 如本文所用術語「周邊耐受性」係藉由使倖免於中樞耐受性之自身反應性T細胞下調或無反應或促使該等T細胞分化成Treg而在周邊中受影響之耐受性。 術語「樣品」可包括藉由包括靜脈穿刺、排泄、射精、按摩、生檢、針抽吸、灌洗樣品、刮擦、手術切口或介入在內之方式或業內已知之其他方式自個體獲取之單個細胞或多個細胞或細胞之片段或體液之等份。 術語「個體」涵蓋人類或非人類細胞、組織或生物體,無論活體內、離體或活體外、雄性或雌性。術語個體包括哺乳動物,包括人類。 術語「哺乳動物」涵蓋人類及非人類二者且包括(但不限於)人類、非人類靈長類動物、犬、貓、鼠類、牛、馬及豬。 術語「臨床因素」係指個體病況(例如疾病活動性或嚴重程度)之量度。「臨床因素」涵蓋個體健康狀況之所有標記物(包括非樣品標記物)及/或個體之其他特徵,例如(但不限於)年齡及性別。臨床因素可為可自評估個體或測定條件下之個體之樣品(或樣品之群)獲得的評分、值或值集。臨床因素亦可藉由標記物及/或其他參數(例如基因表現代用品)來預測。臨床因素可包括腫瘤類型、腫瘤亞型及吸煙史。 縮寫:MHC:主要組織相容性複合體;HLA:人類白血球抗原或人類MHC基因座;NGS:下一代測序;PPV:陽性預測值;TSNA:腫瘤特異性新抗原;FFPE:經福馬林固定、石蠟包埋;NMD:無義介導之衰變;NSCLC:非小細胞肺癌;DC:樹突細胞。 應注意,除非上下文另外明確指明,否則如本說明書及隨附申請專利範圍中所用之單數形式「一(a、an)」及「該」包括複數個指示物。 本文中未直接定義之任何術語應理解為具有通常與如本發明領域內所理解相關之含義。在本文中論述某些術語以向實踐者提供闡述本發明各態樣之組合物、裝置、方法及諸如此類以及如何製備或使用其之額外指導。應瞭解,同一事物可以有一種以上之說法。因此,對於本文中所論述術語中之任一或多者可使用替代性語言及同義詞。術語是否詳述或論述於本文中並不重要。提供一些同義詞或可取代方法、材料及諸如此類。除非明確說明,否則一個或幾個同義詞或等效物之陳述並不排除使用其他同義詞或等效物。使用實例(包括術語之實例)係僅出於說明目的且並不限制本文之本發明各態樣之範疇及含義。 出於所有目的,本說明書主體內所引用之所有參考文獻、已頒佈專利及專利申請案之全文皆以引用方式併入本文中。II. 辨識新抗原之方法
本文揭示自個體腫瘤辨識新抗原之方法,該等新抗原可能呈遞於腫瘤之細胞表面上及/或可能具有免疫原性。作為實例,一種該方法可包含以下步驟:獲得個體腫瘤細胞之外顯子體、轉錄體或全基因體腫瘤核苷酸測序數據中之至少一者,其中使用腫瘤核苷酸測序數據來獲得代表新抗原集中每一者之肽序列之數據,且其中每一新抗原之肽序列包含至少一個使其不同於相應野生型親代肽序列之變化;將每一新抗原之肽序列輸入一或多種呈遞模型中以產生每一新抗原係由個體腫瘤細胞之腫瘤細胞表面或存在於腫瘤中之細胞上的一或多個MHC對偶基因呈遞之數值似然度集,該數值似然度集已至少基於所接收之質譜數據經辨識;及基於數值似然度集選擇新抗原集之子集以產生經選擇新抗原集。 呈遞模型可包含對包含相應標記集之參考數據集(亦稱為訓練數據集)進行訓練之統計回歸或機器學習(例如,深度學習)模型,其中參考數據集係自複數個不同個體中之每一者獲得,其中視情況一些個體可患有腫瘤,且其中參考數據集包含以下中之至少一者:代表腫瘤組織之外顯子體核苷酸序列之數據、代表正常組織之外顯子體核苷酸序列之數據、代表腫瘤組織之轉錄體核苷酸序列之數據、代表腫瘤組織之蛋白質體序列之數據以及代表腫瘤組織之MHC肽體序列之數據及代表正常組織之MHC肽體序列之數據。參考數據可進一步包含單一對偶基因細胞系(其經改造以表現預定MHC對偶基因且隨後暴露於合成蛋白)、正常及腫瘤人類細胞系以及新鮮及冷凍原始樣品及T細胞分析(例如,ELISPOT)之質譜數據、測序數據、RNA-seq數據及蛋白質體學數據。在某些態樣中,參考數據集包括參考數據之每一形式。 呈遞模型可包含至少部分源自參考數據集之特徵集,且其中特徵集包含對偶基因依賴性特徵及非對偶基因依賴性特徵中之至少一者。在某些態樣中包括每一特徵。 樹突細胞對原初T細胞特徵之呈遞可包含以下中之至少一者:上文所述之特徵。疫苗中抗原之劑量及類型。(例如,肽、mRNA、病毒等):(1) 樹突細胞(DC)吸收抗原類型之途徑(例如,胞吞作用、微胞飲作用);及/或(2) DC所吸收抗原之效能。疫苗中佐劑之劑量及類型。疫苗抗原序列之長度。疫苗投與之次數及位點。基線患者免疫功能(例如,如藉由最近感染史、血球計數等所量測)。對於RNA疫苗:(1) 樹突細胞中mRNA蛋白質產物之轉換率;(2) mRNA在由樹突細胞攝取後之轉譯速率,如在活體外或活體內實驗中所量測;及/或(3) mRNA在由樹突細胞攝取後之轉譯次數或週期,如藉由活體內或活體外實驗所量測。肽中蛋白酶裂解基序之存在,該等裂解基序視情況給予通常在樹突細胞中表現之蛋白酶額外重量(如藉由RNA-seq或質譜所量測)。典型活化樹突細胞中蛋白酶體及免疫蛋白酶體之表現量(其可藉由RNA-seq、質譜、免疫組織化學或其他標準技術來量測)。所討論個體中特定MHC對偶基因之表現量(例如,如藉由RNA-seq或質譜所量測),視情況在活化樹突細胞或其他免疫細胞中特異性量測。在表現特定MHC對偶基因之其他個體中特定MHC對偶基因之肽呈遞機率,視情況在活化樹突細胞或其他免疫細胞中特異性量測。在其他個體中同一分子家族中之MHC對偶基因(例如,HLA-A、HLA-B、HLA-C、HLA-DQ、HLA-DR、HLA-DP)之肽呈遞機率,視情況在活化樹突細胞或其他免疫細胞中特異性量測。 免疫耐受性逃脫特徵可包含以下中之至少一者:經由對一或若干細胞類型實施之蛋白質質譜直接量測自身肽體。藉由聯合自身蛋白質之所有k聚體(例如5-25)子串來估計自身肽體。利用與上文所述應用於所有非突變自身蛋白質之呈遞模型相似之呈遞模型來估計自身肽體,視情況將生殖系變體考慮在內。 可至少部分基於數值似然度使用由至少一種模型提供之複數種新抗原來實施分級。在分級後,可根據選擇準則實施選擇以選擇經分級新抗原之亞組。在選擇後,可提供經分級肽之亞組作為輸出。 經選擇新抗原集之數量可為20。 呈遞模型可代表以下各項之間之依賴性:特定一個MHC對偶基因及肽序列特定位置之特定胺基酸之對的存在;與該對之特定一個MHC對偶基因對包含特定位置之特定胺基酸之該肽序列的於腫瘤細胞表面上之呈遞似然度。 本文所揭示之方法亦可包括將一或多種呈遞模型應用於相應新抗原之肽序列以產生一或多個MHC對偶基因中每一者之依賴性評分,其指示MHC對偶基因是否將基於至少相應新抗原之肽序列之胺基酸位置來呈遞相應新抗原。 本文所揭示之方法亦可包括轉換依賴性評分以產生每一MHC對偶基因之相應每一對偶基因似然度,其指示相應MHC對偶基因將呈遞相應新抗原之似然度;及組合每一對偶基因似然度以產生數值似然度。 轉換依賴性評分之步驟可將相應新抗原之肽序列之呈遞建模為互斥。 本文所揭示之方法亦可包括轉換依賴性評分之組合以產生數值似然度。 轉換依賴性評分之組合之步驟可將相應新抗原之肽序列之呈遞建模為MHC對偶基因之間之干擾。 數值似然度集可進一步藉由至少對偶基因非相互作用特徵來辨識,且本文所揭示之方法亦可包括將一或多種呈遞模型中之對偶基因非相互作用者應用於對偶基因非相互作用特徵以產生對偶基因非相互作用特徵之依賴性評分,其指示相應新抗原之肽序列是否將基於對偶基因非相互作用特徵來呈遞。 本文所揭示之方法亦可包括組合一或多個MHC對偶基因中之每一MHC對偶基因之依賴性評分與對偶基因非相互作用特徵之依賴性評分;轉換每一MHC對偶基因之經組合依賴性評分以產生MHC對偶基因之相應每一對偶基因似然度,其指示相應MHC對偶基因將呈遞相應新抗原之似然度;及組合每一對偶基因似然度以產生數值似然度。 本文所揭示之方法亦可包括轉換每一MHC對偶基因之依賴性評分及對偶基因非相互作用特徵之依賴性評分的組合以產生數值似然度。 呈遞模型之數值參數集可基於訓練數據集來訓練,該訓練數據集包括至少辨識為存在於複數個樣品中之訓練肽序列集及一或多個與每一訓練肽序列相關之MHC對偶基因,其中訓練肽序列係經由自源自複數個樣品之MHC對偶基因溶析之分離肽的質譜來辨識。 樣品亦可包括經改造以表現單一I類或II類MHC對偶基因之細胞系。 樣品亦可包括經改造以表現複數個I類或II類MHC對偶基因之細胞系。 樣品亦可包括自複數個患者獲得或源自其之人類細胞系。 樣品亦可包括自複數個患者獲得之新鮮或冷凍腫瘤樣品。 樣品亦可包括自複數個患者獲得之新鮮或冷凍組織樣品。 樣品亦可包括利用T細胞分析辨識之肽。 訓練數據集可進一步包括與以下各項相關之數據:存在於樣品中之訓練肽集之肽豐度;樣品中訓練肽集之肽長度。 訓練數據集可經由與包含已知蛋白質序列集之數據庫比對比較訓練肽集序列來產生,其中訓練蛋白質序列集長於且包括訓練肽序列。 訓練數據集可基於對細胞系實施或已實施核苷酸測序來產生以獲得細胞系之外顯子體、轉錄體或全基因體測序數據中之至少一者,測序數據包括至少一個包括變化之核苷酸序列。 訓練數據集可基於獲得正常組織樣品之外顯子體、轉錄體及全基因體正常核苷酸測序數據中之至少一者來產生。 訓練數據集可進一步包括與樣品相關之蛋白質體序列相關之數據。 訓練數據集可進一步包括與樣品相關之MHC肽體序列相關之數據。 訓練數據集可進一步包括與針對至少一個分離肽之肽-MHC結合親和力量測值相關之數據。 訓練數據集可進一步包括與針對至少一個分離肽之肽-MHC結合穩定性量測值相關之數據。 訓練數據集可進一步包括與樣品相關之轉錄體相關之數據。 訓練數據集可進一步包括與樣品相關之基因體相關之數據。 訓練肽序列可具有介於k聚體範圍內之長度,其中對於I類MHC,k介於8-15之間且包括8及15,或對於II類MHC,k介於9-30之間且包括9及30。 本文所揭示之方法亦可包括利用獨熱編碼方案來編碼肽序列。 本文所揭示之方法亦可包括利用左填充獨熱編碼方案來編碼訓練肽序列。 治療患有腫瘤之個體之方法,其包含實施技術方案1之步驟,且進一步包含獲得包含經選擇新抗原集之腫瘤疫苗,及向個體投與腫瘤疫苗。 本文亦揭示製造腫瘤疫苗之方法,其包含以下步驟:獲得個體腫瘤細胞之外顯子體、轉錄體或全基因體腫瘤核苷酸測序數據中之至少一者,其中使用腫瘤核苷酸測序數據來獲得代表新抗原集中每一者之肽序列之數據,且其中每一新抗原之肽序列包含至少一個使其不同於相應野生型親代肽序列之變化;將每一新抗原之肽序列輸入一或多種呈遞模型中以產生每一新抗原係由個體腫瘤細胞之腫瘤細胞表面上的一或多個MHC對偶基因呈遞之數值似然度集,該數值似然度集已至少基於所接收之質譜數據經辨識;及基於數值似然度集選擇新抗原集之子集以產生經選擇新抗原集;及產生或已產生包含經選擇新抗原集之腫瘤疫苗。 本文亦揭示包括經選擇新抗原集之腫瘤疫苗,該經選擇新抗原集係藉由實施包含以下步驟之方法來選擇:獲得個體腫瘤細胞之外顯子體、轉錄體或全基因體腫瘤核苷酸測序數據中之至少一者,其中使用腫瘤核苷酸測序數據來獲得代表新抗原集中每一者之肽序列之數據,且其中每一新抗原之肽序列包含至少一個使其不同於相應野生型親代肽序列之突變;將每一新抗原之肽序列輸入一或多種呈遞模型中以產生每一新抗原係由個體腫瘤細胞之腫瘤細胞表面上之一或多個MHC對偶基因呈遞的數值似然度集,該數值似然度集已至少基於所接收之質譜數據經辨識;及基於數值似然度集選擇新抗原集之子集以產生經選擇新抗原集;及產生或已產生包含經選擇新抗原集之腫瘤疫苗。 腫瘤疫苗可包括核苷酸序列、多肽序列、RNA、DNA、細胞、質體或載體中之一或多者。 腫瘤疫苗可包括一或多種呈遞於腫瘤細胞表面上之新抗原。 腫瘤疫苗可包括一或多種在個體中有免疫原性之新抗原。 腫瘤疫苗可不包括一或多種誘導針對個體中之正常組織之自體免疫反應之新抗原。 腫瘤疫苗可包括佐劑。 腫瘤疫苗可包括賦形劑。 本文所揭示之方法亦可包括基於呈遞模型選擇相對於未經選擇之新抗原具有增加的呈遞於腫瘤細胞表面上之似然度的新抗原。 本文所揭示之方法亦可包括基於呈遞模型選擇相對於未經選擇之新抗原具有增加的能夠誘導個體中之腫瘤特異性免疫反應之似然度的新抗原。 本文所揭示之方法亦可包括基於呈遞模型選擇相對於未經選擇之新抗原具有增加的能夠藉由專業抗原呈遞細胞(APC)呈遞至原初T細胞之似然度的新抗原,視情況其中該APC係樹突細胞(DC)。 本文所揭示之方法亦可包括基於呈遞模型選擇相對於未經選擇之新抗原具有減小的經歷經由中樞或周邊耐受性抑制之似然度的新抗原。 本文所揭示之方法亦可包括基於呈遞模型選擇相對於未經選擇之新抗原具有減小的能夠誘導針對個體中之正常組織之自體免疫反應之似然度的新抗原。 外顯子體或轉錄體核苷酸測序數據可藉由對腫瘤組織實施測序來獲得。 測序可為下一代測序(NGS)或任一大量平行測序方法。 數值似然度集可進一步藉由至少MHC對偶基因相互作用特徵步來辨識,該等特徵包含以下中之至少一者:經預測MHC對偶基因及新抗原編碼肽結合之親和力;經預測新抗原編碼肽-MHC複合體之穩定性;新抗原編碼肽之序列及長度;具有相似序列之新抗原編碼肽在表現特定MHC對偶基因之其他個體之細胞中之呈遞機率,如藉由質譜蛋白質體學或其他方式所評價;特定MHC對偶基因在所討論個體中之表現量(例如如藉由RNA-seq或質譜所量測);在表現特定MHC對偶基因之其他不同個體中藉由特定MHC對偶基因呈遞之總體新抗原編碼肽序列非依賴性機率;在其他不同個體中之同一家族分子(例如,HLA-A、HLA-B、HLA-C、HLA-DQ、HLA-DR、HLA-DP)中藉由MHC對偶基因呈遞之總體新抗原編碼肽序列非依賴性機率。 數值似然度集係進一步藉由至少MHC對偶基因非相互作用特徵來辨識,該等特徵包含以下中之至少一者:在其源蛋白序列內側接新抗原編碼肽之C末端及N末端序列;在新抗原編碼肽中存在蛋白酶裂解基序,視情況根據相應蛋白酶在腫瘤細胞中之表現(如藉由RNA-seq或質譜所量測)來加權;如在適宜細胞類型中量測之源蛋白之轉換率;源蛋白之長度,視情況考慮在腫瘤細胞中最高表現之特異性剪接變體(「異型體(isoforms)」),如藉由RNA-seq或蛋白質體質譜所量測,或如根據在DNA或RNA序列數據中檢測到之生殖系或體細胞剪接突變之註解所預測;蛋白酶體、免疫蛋白酶體、胸腺蛋白酶體或其他蛋白酶在腫瘤細胞中之表現量(其可藉由RNA-seq、蛋白質體質譜或免疫組織化學來量測);新抗原編碼肽之源基因之表現(例如,如藉由RNA-seq或質譜所量測);新抗原編碼肽之源基因在細胞週期之各個階段期間之典型組織特異性表現;源蛋白及/或其結構域之特徵總目,如可參見例如uniProt或PDB http://www.rcsb.org/pdb/home/home.do;闡述含有肽之源蛋白之結構域性質之特徵,例如:二級或三級結構(例如,α螺旋對β褶板);選擇式剪接;所討論新抗原編碼肽之源蛋白之肽在其他不同個體中之呈遞機率;因技術偏差無法藉由質譜檢測或過表該肽之機率;如藉由RNASeq所量測之多個基因模組/路徑(其無需含有肽之源蛋白)之表現,該等基因模組/路徑提供關於腫瘤細胞、基質或腫瘤浸潤淋巴球(TIL)之狀態之資訊;腫瘤細胞中新抗原編碼肽之源基因之拷貝數;肽結合至TAP之機率或經量測或預測之肽與TAP之結合親和力;TAP在腫瘤細胞中之表現量(其可藉由RNA-seq、蛋白質體質譜、免疫組織化學來量測);存在或不存在腫瘤突變,包括(但不限於):在諸如EGFR、KRAS、ALK、RET、ROS1、TP53、CDKN2A、CDKN2B、NTRK1、NTRK2、NTRK3等已知癌症驅動基因中之驅動突變,及在編碼參與抗原呈遞機制之蛋白質之基因(例如,B2M、HLA-A、HLA-B、HLA-C、TAP-1、TAP-2、TAPBP、CALR、CNX、ERP57、HLA-DM、HLA-DMA、HLA-DMB、HLA-DO、HLA-DOA、HLA-DOBHLA-DP、HLA-DPA1、HLA-DPB1、HLA-DQ、HLA-DQA1、HLA-DQA2、HLA-DQB1、HLA-DQB2、HLA-DR、HLA-DRA、HLA-DRB1、HLA-DRB3、HLA-DRB4、HLA-DRB5或編碼蛋白酶體或免疫蛋白酶體之組份之基因中的任一者)中。呈遞依賴於抗原呈遞機制之組份之肽具有減小的呈遞機率,該抗原呈遞機制之組份在腫瘤中經歷功能喪失型突變;存在或不存在功能生殖系多型性,包括(但不限於):在編碼參與抗原呈遞機制之蛋白質之基因(例如,B2M、HLA-A、HLA-B、HLA-C、TAP-1、TAP-2、TAPBP、CALR、CNX、ERP57、HLA-DM、HLA-DMA、HLA-DMB、HLA-DO、HLA-DOA、HLA-DOBHLA-DP、HLA-DPA1、HLA-DPB1、HLA-DQ、HLA-DQA1、HLA-DQA2、HLA-DQB1、HLA-DQB2、HLA-DR、HLA-DRA、HLA-DRB1、HLA-DRB3、HLA-DRB4、HLA-DRB5或編碼蛋白酶體或免疫蛋白酶體之組份之基因中的任一者)中;腫瘤類型(例如,NSCLC、黑色素瘤);臨床腫瘤亞型(例如,鱗狀肺癌對非鱗狀);吸煙史;肽之源基因在相關腫瘤類型或臨床亞型中之典型表現,視情況藉由驅動突變分層。 至少一個突變可為框移或非框移插入/缺失、誤義或無義取代、剪接位點變化、基因體重排或基因融合或產生neoORF之任何基因體或表現變化。 腫瘤細胞可選自由以下組成之群:肺癌、黑色素瘤、乳癌、卵巢癌、前列腺癌、腎癌、胃癌、結腸癌、睪丸癌、頭頸癌、胰臟癌、腦癌、B細胞淋巴瘤、急性骨髓性白血病、慢性骨髓性白血病、慢性淋巴球性白血病及T細胞淋巴球性白血病、非小細胞肺癌及小細胞肺癌。 本文所揭示之方法亦可包括獲得包含經選擇新抗原集或其子集之腫瘤疫苗,視情況進一步包含向個體投與腫瘤疫苗。 經選擇新抗原集中之至少一種新抗原在呈多肽形式時可包括以下中之至少一者:與MHC之結合親和力之IC50值小於1000 nM;對於1類MHC多肽,長度為8-15個,8個、9個、10個、11個、12個、13個、14個或15個胺基酸;在親代蛋白質序列中之多肽內或附近存在促進蛋白酶體裂解之序列基序;及存在促進TAP轉運之序列基序。 本文亦揭示產生用於辨識一或多種可能呈遞於腫瘤細胞之腫瘤細胞表面上之新抗原之模型的方法,其包含以下步驟:接收質譜數據,其包含與自源自複數個樣品之主要組織相容性複合體(MHC)溶析之複數個分離肽相關之數據;藉由至少辨識存在於樣品中之訓練肽序列集及一或多個與每一訓練肽序列相關之MHC來獲得訓練數據集;利用包含訓練肽序列之訓練數據集來訓練呈遞模型之數值參數集,該呈遞模型提供腫瘤細胞之肽序列係由腫瘤細胞表面上之一或多個MHC對偶基因呈遞之複數種數值似然度。 呈遞模型可代表以下各項之間之依賴性:肽序列特定位置之特定胺基酸之存在;與腫瘤細胞上之一個MHC對偶基因對含有特定位置之特定胺基酸之肽序列的呈遞似然度。 樣品亦可包括經改造以表現單一I類或II類MHC對偶基因之細胞系。 樣品亦可包括經改造以表現複數個I類或II類MHC對偶基因之細胞系。 樣品亦可包括自複數個患者獲得或源自其之人類細胞系。 樣品亦可包括自複數個患者獲得之新鮮或冷凍腫瘤樣品。 樣品亦可包括利用T細胞分析辨識之肽。 訓練數據集可進一步包括與以下各項相關之數據:存在於樣品中之訓練肽集之肽豐度;樣品中訓練肽集之肽長度。 本文所揭示之方法亦可包括經由與包含已知蛋白質序列集之數據庫比對比較訓練肽序列集來獲得基於訓練肽序列之訓練蛋白質序列集,其中該訓練蛋白質序列集長於且包括訓練肽序列。 本文所揭示之方法亦可包括對細胞系實施或已實施質譜以獲得細胞系之外顯子體、轉錄體或全基因體核苷酸測序數據中之至少一者,該核苷酸測序數據包括至少一個包括突變之蛋白質序列。 本文所揭示之方法亦可包括:利用獨熱編碼方案來編碼訓練肽序列。 本文所揭示之方法亦可包括獲得正常組織樣品之外顯子體、轉錄體及全基因體正常核苷酸測序數據中之至少一者;及利用正常核苷酸測序數據來訓練呈遞模型之參數集。 訓練數據集可進一步包括與樣品相關之蛋白質體序列相關之數據。 訓練數據集可進一步包括與樣品相關之MHC肽體序列相關之數據。 訓練數據集可進一步包括與針對至少一個分離肽之肽-MHC結合親和力量測值相關之數據。 訓練數據集可進一步包括與針對至少一個分離肽之肽-MHC結合穩定性量測值相關之數據。 訓練數據集可進一步包括與樣品相關之轉錄體相關之數據。 訓練數據集可進一步包括與樣品相關之基因體相關之數據。 本文所揭示之方法亦可包括使參數集邏輯回歸。 訓練肽序列可具有介於k聚體範圍內之長度,其中對於I類MHC,k介於8-15之間且包括8及15,或對於II類MHC,k介於9-30之間且包括9及30。 本文所揭示之方法亦可包括利用左填充獨熱編碼方案來編碼訓練肽序列。 本文所揭示之方法亦可包括利用深度學習演算法來確定參數集之值。 本文揭示用於辨識一或多種可能呈遞於腫瘤細胞之腫瘤細胞表面上之新抗原之方法,其包含執行以下步驟:接收質譜數據,其包含與自源自複數個新鮮或冷凍腫瘤樣品之主要組織相容性複合體(MHC)溶析之複數個分離肽相關之數據;藉由至少辨識存在於腫瘤樣品中且呈遞於一或多個與每一訓練肽序列相關之MHC對偶基因上之訓練肽序列集來獲得訓練數據集;基於訓練肽序列獲得訓練蛋白質序列集;及利用訓練蛋白質序列及訓練肽序列來訓練呈遞模型之數值參數集,該呈遞模型提供腫瘤細胞之肽序列係由腫瘤細胞表面上之一或多個MHC對偶基因呈遞之複數種數值似然度。 呈遞模型可代表以下各項之間之依賴性:特定一個MHC對偶基因及肽序列特定位置之特定胺基酸之對的存在;與該對之特定一個MHC對偶基因對包含特定位置之特定胺基酸之該肽序列的於腫瘤細胞表面上之呈遞似然度。 本文所揭示之方法亦可包括選擇新抗原之亞組,其中選擇新抗原之亞組之原因在於,相對於一或多種不同的腫瘤新抗原,每一者具有增加的呈遞於腫瘤細胞表面上之似然度。 本文所揭示之方法亦可包括選擇新抗原之亞組,其中選擇新抗原之亞組之原因在於,相對於一或多種不同的腫瘤新抗原,每一者具有增加的能夠誘導個體中之腫瘤特異性免疫反應之似然度。 本文所揭示之方法亦可包括選擇新抗原之亞組,其中選擇新抗原之亞組之原因在於,相對於一或多種不同的腫瘤新抗原,每一者具有增加的能夠藉由專業抗原呈遞細胞(APC)呈遞至原初T細胞之似然度,視情況其中該APC係樹突細胞(DC)。 本文所揭示之方法亦可包括選擇新抗原之亞組,其中選擇新抗原之亞組之原因在於,相對於一或多種不同的腫瘤新抗原,每一者具有減小的經歷經由中樞或周邊耐受性抑制之似然度。 本文所揭示之方法亦可包括選擇新抗原之亞組,其中選擇新抗原之亞組之原因在於,相對於一或多種不同的腫瘤新抗原,每一者具有減小的能夠誘導針對個體中之正常組織之自體免疫反應之似然度。 本文所揭示之方法亦可包括選擇新抗原之亞組,其中選擇新抗原之亞組之原因在於,在腫瘤細胞對APC中每一者具有減小的經差別轉譯後修飾之似然度,視情況其中該APC係樹突細胞(DC)。 除非另有指示,否則本文方法之實踐將採用熟習此項技術者所熟知之習用蛋白質化學、生物化學、重組DNA技術及藥理學方法。該等技術於文獻中充分解釋。例如,參見T.E. Creighton,Proteins: Structures and Molecular Properties
(W.H. Freeman and Company, 1993);A.L. Lehninger,Biochemistry
(Worth Publishers, Inc.,目前新增);Sambrook等人,Molecular Cloning: A Laboratory Manual
(第2版,1989);Methods In Enzymology
(S. Colowick及N. Kaplan編輯,Academic Press, Inc.);Remington's Pharmaceutical Sciences
,第18版(Easton, Pennsylvania: Mack Publishing Company, 1990);Carey及SundbergAdvanced Organic Chemistry 第 3 版
(Plenum Press) A卷及B卷(1992)。III. 新抗原中腫瘤特異性突變之辨識
本文亦揭示用於辨識某些突變(例如,存在於癌細胞中之變體或對偶基因)之方法。具體而言,該等突變可存在於患有癌症之個體癌細胞中之基因體、轉錄體、蛋白質體或外顯子體中,但不存在於該個體之正常組織中。 若腫瘤中之遺傳突變排他性地引起腫瘤中蛋白質之胺基酸序列變化,則可認為該等遺傳突變可用於腫瘤之免疫靶向。有用突變包括:(1) 非同義突變,其產生蛋白質中之不同胺基酸;(2) 通讀突變,其中終止密碼子經修飾或缺失,使得在C末端具有新穎腫瘤特異性序列之較長蛋白質轉譯;(3) 剪接位點突變,其使得在成熟mRNA中納入內含子且因此產生獨特的腫瘤特異性蛋白質序列; (4) 染色體重排,其產生在2種蛋白質之接合處具有腫瘤特異性序列之嵌合蛋白(即,基因融合);(5) 框移突變或缺失,其產生具有新穎腫瘤特異性蛋白質序列之新開放閱讀框。突變亦可包括以下中之一或多者:非框移插入/缺失、誤義或無義取代、剪接位點變化、基因體重排或基因融合或產生neoORF之任何基因體或表現變化。 腫瘤細胞中具有突變之肽或源自例如剪接位點、框移、通讀或基因融合突變之突變多肽可藉由對腫瘤對正常細胞中之DNA、RNA或蛋白質測序來辨識。 突變亦可包括先前辨識之腫瘤特異性突變。已知腫瘤突變可參見癌症之體細胞突變目錄(Catalogue of Somatic Mutations in Cancer,COSMIC)數據庫。 可使用多種方法來檢測個體DNA或RNA中具體突變或對偶基因之存在。在此領域中之先進性已提供準確、容易且廉價之大規模SNP基因分型。舉例而言,業內已闡述若干技術,包括動態對偶基因特異性雜交(DASH)、微量板陣列對角線凝膠電泳(MADGE)、焦磷酸測序、寡核苷酸特異性連結、TaqMan系統以及多種DNA「晶片」技術(例如Affymetrix SNP晶片)。該等方法利用通常藉由PCR來擴增靶遺傳區域。其他方法基於藉由侵入性裂解產生小信號分子,然後進行質譜或經固定扣鎖探針及滾環擴增。業內已知用於檢測特異性突變之若干方法概述於下文中。 基於PCR之檢測方法可包括複數個標記物之同時多重擴增。舉例而言,業內熟知選擇PCR引子來產生大小不重疊且可同時分析之PCR產物。或者,可用經差別標記且因此各自可經差別檢測之引子來擴增不同標記物。當然,基於雜交之檢測方法允許差別檢測樣品中之多個PCR產物。其他技術為業內已知以允許複數個標記物之多重分析。 業內已研發出若干方法來幫助分析基因體DNA或細胞RNA中之單核苷酸多型性。舉例而言,可藉由使用專門外核酸酶抗性核苷酸來檢測單鹼基多型性,如例如Mundy, C. R. (美國專利第4,656,127號)中所揭示。根據該方法,容許與緊接多型性位點3'之對偶基因序列互補之引子與自具體動物或人類獲得之靶分子雜交。若靶分子上之多型性位點含有與所存在之具體外核酸酶抗性核苷酸衍生物互補之核苷酸,則該衍生物將納入雜交引子之末端上。該納入使得引子對外核酸酶有抗性,且藉此容許其檢測。由於已知樣品之外核酸酶抗性衍生物之身份,引子已變得對外核酸酶有抗性之發現揭露,存在於靶分子之多型性位點中之核苷酸與用於反應中之核苷酸衍生物之核苷酸互補。此方法之優點在於其無需測定大量外源序列數據。 可使用基於溶液之方法來確定多型性位點之核苷酸之身份。Cohen, D.等人(法國專利2,650,840;PCT申請案第WO91/02087號)。如在美國專利第4,656,127號之Mundy方法中,採用與緊接多型性位點3'之對偶基因序列互補之引子。該方法利用經標記之二去氧核苷酸衍生物確定該位點之核苷酸之身份,該等二去氧核苷酸衍生物若與多型性位點之核苷酸互補,則將變得納入引子之末端上。 稱為遺傳位元分析或GBA之替代方法闡述於Goelet, P.等人(PCT申請案第92/15712號)中。Goelet, P.等人之方法使用經標記終止子及與多型性位點3'之序列互補之引子的混合物。因此,所納入之經標記終止子係由存在於所評估靶分子之多型性位點中之核苷酸確定且與其互補。與Cohen等人之方法(法國專利2,650,840;PCT申請案第WO91/02087號)不同,Goelet, P.等人之方法可為異質相分析,其中將引子或靶分子固定至固相。 業內已闡述用於分析DNA中之多型性位點之若干引子引導之核苷酸納入程序(Komher, J. S.等人,Nucl. Acids. Res. 17:7779-7784 (1989);Sokolov, B. P., Nucl. Acids Res. 18:3671 (1990);Syvanen, A.-C.等人,Genomics 8:684-692 (1990);Kuppuswamy, M. N.等人,Proc. Natl. Acad. Sci. (U.S.A.) 88:1143-1147 (1991);Prezant, T. R.等人,Hum. Mutat. 1:159-164 (1992);Ugozzoli, L.等人,GATA 9:107-112 (1992);Nyren, P.等人,Anal. Biochem. 208:171-175 (1993))。該等方法與GBA之不同之處在於,其利用納入經標記去氧核苷酸來區分多型性位點之鹼基。在該格式中,由於信號與所納入去氧核苷酸之數量成比例,故在相同核苷酸之運行中出現之多型性可產生與運行之長度成比例之信號(Syvanen, A.-C.等人,Amer. J. Hum. Genet. 52:46-59 (1993))。 大量行動直接自數百萬個個別DNA或RNA分子並行獲得序列資訊。即時單分子合成測序技術依賴於螢光核苷酸在納入與所測序模板互補之初生DNA股中時之檢測。在一方法中,將長度為30-50個鹼基之寡核苷酸之5'末端共價錨定至玻璃蓋玻片。該等錨定股具有兩種功能。第一,其在模板經構形具有與表面結合寡核苷酸互補之捕獲尾時用作靶模板股之捕獲位點。其亦作為引子用於形成序列讀取基礎之模板引導之引子延伸。捕獲引子用作固定位置位點利用多個合成、檢測及化學裂解染料-連接體以移除染料之週期進行序列測定。每一週期係由添加聚合酶/經標記核苷酸混合物、沖洗、成像及裂解染料組成。在替代方法中,聚合酶經螢光供體分子修飾且固定於載玻片上,而每一核苷酸經附接至γ-磷酸酯之受體螢光部分色彩編碼。在經螢光修飾之核苷酸變得納入新生鏈中時,該系統檢測帶有螢光標籤之聚合酶與該核苷酸之間的相互作用。業內亦存在其他合成測序技術。 可使用任何適宜合成測序平臺來辨識突變。如上文所述,當前可獲得四個主要的合成測序平臺:來自Roche/454 Life Sciences之基因體測序儀、來自Illumina/Solexa之1G分析儀、來自Applied BioSystems之SOLiD系統及來自Helicos Biosciences之Heliscope系統。合成測序平臺亦已闡述於Pacific BioSciences and VisiGen Biotechnologies中。在一些實施例中,使複數個所測序核酸分子結合至載體(例如,固體載體)。為使核酸固定於載體上,可在模板之3'及/或5'末端添加捕獲序列/通用啟動位點。可藉由使捕獲序列與共價附接至載體之互補序列雜交使核酸結合至載體。捕獲序列(亦稱為通用捕獲序列)係與附接至載體之序列互補之核酸序列,其可雙重地用作通用引子。 作為捕獲序列之替代,偶合對(例如抗體/抗原對、受體/配體對或抗生物素蛋白-生物素對,如例如美國專利申請案第2006/0252077號中所述)之成員可連接至每一片段以在經該偶合對之各別第二成員塗覆之表面上被捕獲。 在捕獲後,可例如藉由單分子檢測/測序來分析序列,例如如實例中及美國專利第7,283,337號中所述,包括模板依賴性合成測序。在合成測序中,使表面結合分子在聚合酶存在下暴露於複數個經標記之核苷酸三磷酸酯。根據經標記核苷酸納入生長鏈之3'末端中之順序來確定模板之序列。此可即時進行或可以分步重複模式進行。對於即時分析,可納入針對每一核苷酸之不同光學標記,且可使用多個雷射來刺激所納入之核苷酸。 測序亦可包括其他大量平行測序或下一代測序(NGS)技術及平臺。大量平行測序技術及平臺之其他實例係Illumina HiSeq或MiSeq、Thermo PGM或Proton、Pac Bio RS II或Sequel、Qiagen基因讀取器及Oxford Nanopore MinION。可使用其他類似當前大量平行測序技術以及該等技術之未來世代。 可使用任何細胞類型或組織來獲得用於本文所述方法中之核酸樣品。舉例而言,可自腫瘤或體液(例如藉由已知技術(例如靜脈穿刺)獲得之血液或唾液)獲得DNA或RNA樣品。或者,可對乾燥樣品(例如毛髮或皮膚)實施核酸測試。另外,可自腫瘤獲得樣品用於測序且可自正常組織獲得另一樣品用於測序,其中正常組織具有與腫瘤相同之組織類型。可自腫瘤獲得樣品用於測序且可自正常組織獲得另一樣品用於測序,其中正常組織具有相對於腫瘤不同之組織類型。 腫瘤可包括以下中之一或多者:肺癌、黑色素瘤、乳癌、卵巢癌、前列腺癌、腎癌、胃癌、結腸癌、睪丸癌、頭頸癌、胰臟癌、腦癌、B細胞淋巴瘤、急性骨髓性白血病、慢性骨髓性白血病、慢性淋巴球性白血病及T細胞淋巴球性白血病、非小細胞肺癌及小細胞肺癌。 或者,可使用蛋白質質譜來辨識或驗證結合至腫瘤細胞上之MHC蛋白之突變肽之存在。肽可自腫瘤細胞或自腫瘤免疫沈澱之HLA分子進行酸溶析,且然後利用質譜辨識。IV. 新抗原
新抗原可包括核苷酸或多肽。舉例而言,新抗原可為編碼多肽序列之RNA序列。因此,可用於疫苗中之新抗原可包括核苷酸序列或多肽序列。 本文揭示包含藉由本文所揭示之方法辨識之腫瘤特異性突變之分離肽、包含已知腫瘤特異性突變之肽及藉由本文所揭示之方法辨識之突變體多肽或其片段。新抗原肽可闡述於其編碼序列背景下,其中新抗原包括編碼相關多肽序列之核苷酸序列(例如,DNA或RNA)。 一或多種由新抗原核苷酸序列編碼之多肽可包含以下中之至少一者:與MHC之結合親和力之IC50值小於1000 nM;對於1類MHC肽,長度為8-15個,8個、9個、10個、11個、12個、13個、14個或15個胺基酸;在肽內或附近存在促進蛋白酶體裂解之序列基序;及存在促進TAP轉運之序列基序。 一或多種新抗原可呈遞於腫瘤之表面上。 一或多種新抗原在患有腫瘤之個體中可具有免疫原性,例如能夠引發個體中之T細胞反應或B細胞反應。 在患有腫瘤之個體之疫苗產生背景下可不予考慮一或多種誘導個體中之自體免疫反應之新抗原。 至少一個新抗原肽分子之大小可包含(但不限於)約5個、約6個、約7個、約8個、約9個、約10個、約11個、約12個、約13個、約14個、約15個、約16個、約17個、約18個、約19個、約20個、約21個、約22個、約23個、約24個、約25個、約26個、約27個、約28個、約29個、約30個、約31個、約32個、約33個、約34個、約35個、約36個、約37個、約38個、約39個、約40個、約41個、約42個、約43個、約44個、約45個、約46個、約47個、約48個、約49個、約50個、約60個、約70個、約80個、約90個、約100個、約110個、約120個或更多個胺基分子殘基及其中衍生之任一範圍。在特定實施例中,新抗原肽分子等於或小於50個胺基酸。 新抗原肽及多肽可為:對於I類MHC,長度為15個殘基或更短且通常係由約8個至約11個殘基、具體而言9個或10個殘基組成;對於II類MHC,長度為15-24個殘基。 若需要,可以若干方式設計較長肽。在一情形下,當預測或已知HLA對偶基因上之肽呈遞似然度時,較長肽可由以下中之任一者組成:(1) 朝向每一相應基因產物之N末端及C末端延伸2-5個胺基酸之個別經呈遞肽;(2) 一些或所有經呈遞肽與各自之延伸序列之串聯。在另一情形下,當測序揭露存在於腫瘤中之長(>10個殘基)新表位序列(例如歸因於產生新穎肽序列之框移、通讀或內含子納入)時,較長肽將由以下各項組成:(3) 整段新穎腫瘤特異性胺基酸,因此不需要最強HLA呈遞之較短肽之計算選擇或基於活體外測試之選擇。在兩種情形下,使用較長肽允許藉由患者細胞進行內源處理且可引起更有效的抗原呈遞及T細胞反應誘導。 新抗原肽及多肽可呈遞於HLA蛋白上。在一些態樣中,新抗原肽及多肽以大於野生型肽之親和力呈遞於HLA蛋白上。在一些態樣中,新抗原肽或多肽之IC50可為至少小於5000 nM、至少小於1000 nM、至少小於500 nM、至少小於250 nM、至少小於200 nM、至少小於150 nM、至少小於100 nM、至少小於50 nM或更小。 在一些態樣中,新抗原肽及多肽在投與個體時並不誘導自體免疫反應及/或引起免疫耐受性。 本文亦提供包含至少兩個或更多個新抗原肽之組合物。在一些實施例中,組合物含有至少兩個不同肽。至少兩個不同肽可源自同一多肽。不同多肽意指肽之長度、胺基酸序列或二者有所變化。肽源自已知或已經發現含有腫瘤特異性突變之任何多肽。可衍生出新抗原肽之適宜多肽可參見例如COSMIC數據庫。COSMIC策展(curate)關於人類癌症中之體細胞突變之全面資訊。肽含有腫瘤特異性突變。在一些態樣中,腫瘤特異性突變係具體癌症類型之驅動突變。 具有期望活性或性質之新抗原肽及多肽可經修飾以提供某些期望屬性,例如經改良之藥理學特徵,同時增加或至少保留未經修飾肽之實質上所有的生物活性以結合期望MHC分子並活化適宜T細胞。例如,新抗原肽及多肽可經歷多種變化,例如保守或非保守取代,其中該等變化可提供其應用中之某些優點,例如經改良之MHC結合、穩定性或呈遞。保守取代意指用在生物及/或化學上類似之另一胺基酸殘基替代胺基酸殘基,例如用一個疏水殘基替代另一疏水殘基,或用一個極性殘基替代另一極性殘基。取代包括諸如以下等組合:Gly、Ala;Val、Ile、Leu、Met;Asp、Glu;Asn、Gln;Ser、Thr;Lys、Arg;及Phe、Tyr。單一胺基酸取代之效應亦可利用D-胺基酸來探測。該等修飾可利用如例如以下文獻中所述之熟知肽合成程序來製備:Merrifield, Science 232:341-347 (1986);Barany及Merrifield, The Peptides, Gross及Meienhofer編輯(N.Y., Academic Press),第1-284頁(1979);以及Stewart及Young, Solid Phase Peptide Synthesis, (Rockford, Ill., Pierce)第2版(1984)。 用多種胺基酸模擬物或非天然胺基酸修飾肽及多肽尤其可用於增加活體內肽及多肽之穩定性。穩定性可以多種方式來分析。例如,已使用肽酶及各種生物介質(例如人類血漿及血清)來測試穩定性。例如,參見Verhoef等人,Eur. J. Drug Metab Pharmacokin. 11:291-302 (1986)。可便捷地利用25%人類血清(v/v)分析來測定肽之半衰期。方案通常如下所述。在使用之前藉由離心對經彙集之人類血清(AB型,非熱不活化)脫脂。然後用RPMI組織培養基將血清稀釋至25%且用於測試肽穩定性。以預定時間間隔移除少量反應溶液且添加至6%三氯乙酸水溶液或乙醇中。將渾濁反應樣品冷卻(4℃) 15分鐘且然後旋轉以使沈澱的血清蛋白成團。然後藉由反相HPLC利用穩定性特異性層析條件來確定肽之存在。 肽及多肽可經修飾以提供除經改良之血清半衰期外之期望屬性。例如,可藉由連接至含有至少一個能夠誘導T輔助細胞反應之表位之序列來增強肽誘導CTL活性之能力。免疫原性肽/T輔助偶聯物可藉由間隔體分子來連接。間隔體通常包含在生理條件下實質上不帶電之相對較小之中性分子,例如胺基酸或胺基酸模擬物。間隔體通常選自例如Ala、Gly或非極性胺基酸或中性極性胺基酸之其他中性間隔體。應理解,視情況存在之間隔體無需包含相同殘基且因此可為異源或同源寡聚物。當存在時,間隔體通常將為至少一或兩個殘基,更通常3至6個殘基。或者,肽可不經間隔體連接至T輔助肽。 新抗原肽可直接或經由肽之胺基或羧基末端之間隔體連接至T輔助肽。新抗原肽或T輔助肽之胺基末端可經醯化。實例性T輔助肽包括破傷風類毒素830-843、流行性感冒307-319、瘧疾環子孢子382-398及378-389。 蛋白質或肽可藉由熟習此項技術者已知之任何技術來製備,該技術包括經由標準分子生物技術表現蛋白質、多肽或肽、自天然來源分離蛋白質或肽、或化學合成蛋白或肽。先前已揭示對應於各個基因之核苷酸及蛋白質、多肽及肽序列,且可參見熟習此項技術者已知之電腦化數據庫。一個該數據庫係國家生物技術資訊中心(National Center for Biotechnology Information's Genbank)之基因庫及位於國立衛生研究院(National Institutes of Health)網站之GenPept數據庫。已知基因之編碼區可利用本文所揭示或如熟習此項技術者已知之技術來擴增及/或表現。或者,熟習此項技術者已知蛋白質、多肽及肽之多種商業製劑。 在另一態樣中,新抗原包括編碼新抗原肽或其部分之核酸(例如多核苷酸)。多核苷酸可為例如DNA、cDNA、PNA、CNA、RNA (例如,mRNA),單股及/或雙股或天然或穩定形式之多核苷酸,例如具有硫代磷酸酯主鏈之多核苷酸,或其組合,且其可或可不含內含子。另一態樣提供能夠表現多肽或其部分之表現載體。用於不同細胞類型之表現載體為業內所熟知且可無需過多實驗來選擇。一般而言,將DNA以適當取向及正確閱讀框插入表現載體(例如質體)中用於表現。若需要,可將DNA連接至由期望宿主識別之適宜轉錄及轉譯調控控制核苷酸序列,但該等控制通常可用於表現載體中。然後經由標準技術將載體引入宿主中。指導可參見例如Sambrook等人(1989) Molecular Cloning, A Laboratory Manual, Cold Spring Harbor Laboratory, Cold Spring Harbor, N.Y。IV. 疫苗組合物
本文亦揭示能夠引起特異性免疫反應(例如腫瘤特異性免疫反應)之免疫原性組合物,例如疫苗組合物。疫苗組合物通常包含複數種例如利用本文所述之方法選擇之新抗原。疫苗組合物亦可稱為疫苗。 疫苗可含有1至30種肽、2種、3種、4種、5種、6種、7種、8種、9種、10種、11種、12種、13種、14種、15種、16種、17種、18種、19種、20種、21種、22種、23種、24種、25種、26種、27種、28種、29種或30種不同的肽、6種、7種、8種、9種、10種、11種、12種、13種或14種不同的肽或12種、13種或14種不同的肽。肽可包括轉譯後修飾。疫苗可含有1至100個或更多個核苷酸序列、2個、3個、4個、5個、6個、7個、8個、9個、10個、11個、12個、13個、14個、15個、16個、17個、18個、19個、20個、21個、22個、23個、24個、25個、26個、27個、28個、29個、30個、31個、32個、33個、34個、35個、36個、37個、38個、39個、40個、41個、42個、43個、44個、45個、46個、47個、48個、49個、50個、51個、52個、53個、54個、55個、56個、57個、58個、59個、60個、61個、62個、63個、64個、65個、66個、67個、68個、69個、70個、71個、72個、73個、74個、75個、76個、77個、78個、79個、80個、81個、82個、83個、84個、85個、86個、87個、88個、89個、90個、91個、92個、93個、94個、95個、96個、97個、98個、99個、100個或更多個不同核苷酸序列、6個、7個、8個、9個、10個、11個、12個、13個或14個不同核苷酸序列或12個、13個或14個不同核苷酸序列。疫苗可含有1至30個新抗原序列、2個、3個、4個、5個、6個、7個、8個、9個、10個、11個、12個、13個、14個、15個、16個、17個、18個、19個、20個、21個、22個、23個、24個、25個、26個、27個、28個、29個、30個、31個、32個、33個、34個、35個、36個、37個、38個、39個、40個、41個、42個、43個、44個、45個、46個、47個、48個、49個、50個、51個、52個、53個、54個、55個、56個、57個、58個、59個、60個、61個、62個、63個、64個、65個、66個、67個、68個、69個、70個、71個、72個、73個、74個、75個、76個、77個、78個、79個、80個、81個、82個、83個、84個、85個、86個、87個、88個、89個、90個、91個、92個、93個、94個、95個、96個、97個、98個、99個、100個或更多個不同新抗原序列、6個、7個、8個、9個、10個、11個、12個、13個或14個不同新抗原序列、或12個、13個或14個不同新抗原序列。 在一個實施例中,選擇不同的肽及/或多肽或編碼其之核苷酸序列,以使得肽及/或多肽能夠與不同的MHC分子(例如不同的I類MHC分子)締合。在一些態樣中,一種疫苗組合物包含能夠與最常出現之I類MHC分子締合之肽及/或多肽之編碼序列。因此,疫苗組合物可包含能夠與至少2種較佳、至少3種較佳或至少4種較佳I類MHC分子締合之不同片段。 疫苗組合物可能夠引起特異性細胞毒性T細胞反應及/或特異性輔助T細胞反應。 疫苗組合物可進一步包含佐劑及/或載劑。有用佐劑及載劑之實例於下文給出。組合物可與載劑(例如蛋白質或抗原呈遞細胞,例如能夠將肽呈遞至T細胞之樹突細胞(DC))締合。 佐劑係於疫苗組合物中之混合物增加或以其他方式改質針對新抗原之免疫反應之任何物質。載劑可為新抗原能夠締合之支架結構,例如多肽或多醣。視情況,佐劑共價或非共價偶聯。 佐劑增加針對抗原之免疫反應之能力通常表現為免疫介導之反應顯著或實質性增加或疾病症狀減輕。舉例而言,體液免疫性之增加通常表現為針對抗原產生之抗體效價之顯著增加,且T細胞活性之增加通常係以增加的細胞增殖或細胞細胞毒性或細胞介素分泌來表現。佐劑亦可例如藉由將原發性體液或Th反應變成原發性細胞或Th反應來改變免疫反應。 適宜佐劑包括(但不限於) 1018 ISS、明礬、鋁鹽、Amplivax、AS15、BCG、CP-870,893、CpG7909、CyaA、dSLIM、GM-CSF、IC30、IC31、咪喹莫特(Imiquimod)、ImuFact IMP321、IS貼片、ISS、ISCOMATRIX、JuvImmune、LipoVac、MF59、單磷醯脂質A、Montanide IMS 1312、Montanide ISA 206、Montanide ISA 50V、Montanide ISA-51、OK-432、OM-174、OM-197-MP-EC、ONTAK、PepTel載體系統、PLG微粒、雷西莫特(resiquimod)、SRL172、病毒體及其他類病毒粒子、YF-17D、VEGF捕集器、R848、β-葡聚糖、Pam3Cys、源自皂素之Aquila QS21刺激子(Aquila Biotech, Worcester, Mass., USA)、分枝桿菌提取物及合成細菌細胞壁模擬物及其他專有佐劑(例如Ribi之Detox. Quil或Superfos)。諸如弗氏不完全佐劑(incomplete Freund's adjuvant)或GM-CSF等佐劑係有用的。先前已闡述特異性針對樹突細胞之若干免疫佐劑(例如,MF59)及其製備(Dupuis M等人,Cell Immunol. 1998; 186(1):18-27;Allison A C; Dev Biol Stand. 1998; 92:3-11)。亦可使用細胞介素。若干細胞介素與以下各項直接相關:影響樹突細胞至淋巴組織之遷移(例如,TNF-α)、加速樹突細胞至T淋巴球之有效抗原呈遞細胞之成熟(例如,GM-CSF, IL-1及IL-4) (美國專利第5,849,589號,其全文以引用方式明確併入本文中)及用作免疫佐劑(例如,IL-12) (Gabrilovich D I等人,J Immunother Emphasis Tumor Immunol. 1996 (6):414-418)。 亦已報導CpG免疫刺激寡核苷酸增強佐劑在疫苗環境中之效應。亦可使用其他TLR結合分子,例如結合TLR 7、TLR 8及/或TLR 9之RNA。 有用佐劑之其他實例包括(但不限於)經化學修飾之CpG (例如CpR, Idera)、聚(I:C) (例如聚i:CI2U)、非CpG細菌DNA或RNA以及免疫活性小分子及抗體,例如環磷醯胺、舒尼替尼(sunitinib)、貝伐珠單抗(bevacizumab)、西樂葆(celebrex)、NCX-4016、西地那非(sildenafil)、他達拉非(tadalafil)、伐地那非(vardenafil)、索拉菲尼(sorafinib)、XL-999、CP-547632、帕唑帕尼(pazopanib)、ZD2171、AZD2171、伊匹單抗(ipilimumab)、曲美目單抗(tremelimumab)及SC58175,其可用於治療及/或用作佐劑。佐劑及添加劑之量及濃度可容易地由熟習此項技術者無需過多實驗來確定。其他佐劑包括群落刺激因子,例如粒子球巨噬細胞群落刺激因子(GM-CSF、沙格司亭(sargramostim))。 疫苗組合物可包含一種以上之不同佐劑。此外,治療組合物可包含包括上述任一者或其組合之任何佐劑物質。亦預期疫苗及佐劑可一起投與或以任一適宜序列分開投與。 載劑(或賦形劑)可獨立於佐劑存在。載劑之功能可為例如增加具體而言突變體之分子量以增加活性或免疫原性、賦予穩定性、增加生物活性或延長血清半衰期。此外,載劑可幫助將肽呈遞至T細胞。載劑可為熟習此項技術者已知之任何適宜載劑,例如蛋白質或抗原呈遞細胞。載體蛋白可為(但不限於)鑰孔帽貝血藍蛋白、血清蛋白(例如運鐵蛋白、牛血清白蛋白、人類血清白蛋白、甲狀腺球蛋白或卵白蛋白)、免疫球蛋白或激素(例如胰島素或棕櫚酸)。為對人類進行免疫,載劑通常為生理上可接受之為人類可接受且安全之載劑。然而,破傷風類毒素及/或白喉類毒素係適宜載劑。或者,載劑可為聚葡萄糖,例如瓊脂糖。 細胞毒性T細胞(CTL)識別呈結合至MHC分子之肽形式之抗原而非完整外源性抗原自身。MHC分子自身位於抗原呈遞細胞之細胞表面上。因此,若存在肽抗原、MHC分子及APC之三聚複合體,則可活化CTL。相應地,若不僅使用肽來活化CTL,且若另外一起添加APC與各別MHC分子,則其可增強免疫反應。因此,在一些實施例中,疫苗組合物另外含有至少一種抗原呈遞細胞。 新抗原亦可納入基於病毒載體之疫苗平臺中,例如牛痘、雞痘、自我複製α病毒、馬拉巴病毒(marabavirus)、腺病毒(例如,參見Tatsis等人,Adenoviruses,Molecular Therapy
(2004) 10, 616-629)或慢病毒屬,包括(但不限於)第二代、第三代或雜合第二代/第三代慢病毒屬及經設計以靶向特定細胞類型或受體之任一代重組慢病毒屬(例如,參見Hu等人,Immunization Delivered by Lentiviral Vectors for Cancer and Infectious Diseases,Immunol Rev.
(2011) 239(1): 45-61;Sakuma等人,Lentiviral vectors: basic to translational,Biochem J.
(2012) 443(3):603-18;Cooper等人,Rescue of splicing-mediated intron loss maximizes expression in lentiviral vectors containing the human ubiquitin C promoter,Nucl. Acids Res.
(2015) 43 (1): 682-690;Zufferey等人,Self-Inactivating Lentivirus Vector for Safe and Efficient In Vivo Gene Delivery,J. Virol.
(1998) 72 (12): 9873-9880)。端視上文所提及基於病毒載體之疫苗平臺之包裝能力,此方法可遞送一或多個編碼一或多種新抗原肽之核苷酸序列。該等序列可側接有非突變序列,可藉由連接體分開或之前可為一或多個靶向亞細胞隔室之序列(例如,參見Gros等人,Prospective identification of neoantigen-specific lymphocytes in the peripheral blood of melanoma patients,Nat Med.
(2016) 22 (4):433-8;Stronen等人,Targeting of cancer neoantigens with donor-derived T cell receptor repertoires,Science.
(2016) 352 (6291):1337-41;Lu等人,Efficient identification of mutated cancer antigens recognized by T cells associated with durable tumor regressions,Clin Cancer Res .
(2014) 20(13):3401-10)。在引入宿主中後,受感染細胞表現新抗原,且由此引發針對肽之宿主免疫(例如,CTL)反應。可用於免疫方案中之牛痘載體及方法闡述於例如美國專利第4,722,848號中。另一載體係BCG (卡介苗)。BCG載體闡述於Stover等人(Nature 351:456-460 (1991))中。熟習此項技術者根據本文描述將明瞭可用於新抗原之治療性投與或免疫之眾多種其他疫苗載體,例如傷寒沙氏桿菌(Salmonella typhi)載體及諸如此類。IV.A. 關於疫苗設計及製造之其他考慮因素 IV.A.1. 涵蓋所有腫瘤亞純系之肽集之測定
對幹枝性肽(意指由所有或大部分腫瘤亞純系呈遞之彼等)進行優先級排序以納入疫苗中。53
視情況,若不存在經預測以高機率呈遞且具免疫原性之幹枝性肽,或若經預測以高機率呈遞且具免疫原性之幹枝性肽之數量足夠小使得其他非幹枝性肽可納入疫苗中,則可藉由估計腫瘤亞純系之數量及身份並選擇肽來對其他肽進行優先級排序以最大化疫苗所涵蓋之腫瘤亞純系之數量54
。IV.A.2. 新抗原優先級排序
在施加所有上述新抗原過濾器後,仍可將多於疫苗技術可支持之候選新抗原用於疫苗納入。另外,可保留關於新抗原分析之多個態樣之不確定性且在候選疫苗新抗原之不同性質之間可存在取捨。因此,可考慮整合多維模型來替代選擇過程之每一步驟之預定過濾器,該多維模型將候選新抗原置於具有至少以下軸線之空間中且利用積分方法來最佳化選擇。 1. 自體免疫性或耐受性風險(生殖系風險) (較低的自體免疫性風險通常較佳) 2. 測序假影機率(較低假影機率通常較佳) 3. 免疫原性機率(較高免疫原性機率通常較佳) 4. 呈遞機率(較高呈遞機率通常較佳) 5. 基因表現(較高表現通常較佳) 6. HLA基因之覆蓋率(參與新抗原集呈遞之較大量HLA分子可經由使HLA分子下調或突變來降低腫瘤逃脫免疫攻擊之機率)V. 治療及製造方法
本文亦提供誘導個體中之腫瘤特異性免疫反應、對腫瘤進行疫苗接種、治療及或緩和個體癌症之症狀的方法,其係藉由向個體投與一或多種新抗原(例如複數種利用本文所揭示之方法辨識之新抗原)來實施。 在一些態樣中,個體已經診斷患有癌症或具有罹患癌症之風險。個體可為人類、狗、貓、馬或腫瘤特異性免疫反應合意之任何動物。腫瘤可為任何實體腫瘤,例如乳房腫瘤、卵巢腫瘤、前列腺腫瘤、肺腫瘤、腎腫瘤、胃腫瘤、結腸腫瘤、睪丸腫瘤、頭頸腫瘤、胰臟腫瘤、腦腫瘤、黑色素瘤,及其他組織器官腫瘤及血液腫瘤,例如淋巴瘤及白血病,包括急性骨髓性白血病、慢性骨髓性白血病、慢性淋巴球性白血病、T細胞淋巴球性白血病及B細胞淋巴瘤。 新抗原可以足以誘導CTL反應之量來投與。 新抗原可單獨投與或與其他治療劑組合投與。治療劑係例如化學治療劑、輻射或免疫療法。可對具體癌症投與任何適宜治療性治療。 另外,可向個體進一步投與抗免疫抑制/免疫刺激劑,例如檢查點抑制劑。舉例而言,可向個體進一步投與抗CTLA抗體或抗PD-1或抗PD-L1。藉由抗體阻斷CTLA-4或PD-L1可增強患者對癌細胞之免疫反應。具體而言,已顯示CTLA-4阻斷在遵循疫苗接種方案時係有效的。 可確定欲納入疫苗組合物中之每一新抗原之最佳量及最佳投藥方案。舉例而言,可製備新抗原或其變體用於靜脈內(i.v.)注射、皮下(s.c.)注射、真皮內(i.d.)注射、腹膜內(i.p.)注射、肌內(i.m.)注射。注射方法包括s.c.、i.d.、i.p.、i.m.及i.v.。DNA或RNA注射方法包括i.d.、i.m.、s.c.、i.p.及i.v.。疫苗組合物之其他投與方法為熟習此項技術者已知。 疫苗可經編譯以使得存在於組合物中之新抗原之選擇、數量及/或量具有組織、癌症及/或患者特異性。例如,可藉由親代蛋白質在給定組織中之表現模式來指導肽之確切選擇。該選擇可端視癌症之特定類型、疾病之狀況、早期治療方案、患者之免疫狀況及當然患者之HLA-單倍型而定。此外,根據具體患者之個人需要,疫苗可含有個別化組份。實例包括根據新抗原在具體患者中之表現或對第一輪後之二次治療或治療時間表之調整來改變新抗原之選擇。 對於欲作為癌症疫苗之組合物,具有在正常組織中大量表現之相似正常自身肽之新抗原可避免或以少量存在於本文所述之組合物中。另一方面,若已知患者之腫瘤表現大量某些新抗原,用於治療此癌症之各別醫藥組合物可以大量存在及/或可包括一種以上之特異性針對此具體新抗原或此新抗原路徑之新抗原。 包含新抗原之組合物可投與已患有癌症之個體。在治療性應用中,組合物係以足以引發針對腫瘤抗原之有效CTL反應並治癒或至少部分地阻止症狀及/或併發症的量投與患者。足以實現此效果之量定義為「治療有效劑量」。可有效地用於此應用之量將端視例如組合物、投與方式、所治療疾病之階段及嚴重程度、患者之體重及一般健康狀態以及開處醫師之判斷而定。應理解,組合物通常可用於嚴重疾病狀態,亦即危及生命或可能危及生命之情形,尤其當癌症已轉移時。在該等情形下,鑒於外源物質之最小化及新抗原之相對無毒性質,可投與實質上過量之該等組合物且治療醫師可認為合意。 對於治療性用途,投與可開始於檢測或手術移除腫瘤。此後為加強劑量直至至少症狀實質上減退且之後保持一定時段。 用於治療性治療之醫藥組合物(例如,疫苗組合物)欲用於非經腸、外用、經鼻、經口或局部投與。醫藥組合物可非經腸(例如靜脈內、皮下、真皮內或肌內)投與。組合物可投與手術切口之位點來誘導針對腫瘤之局部免疫反應。本文揭示包含新抗原溶液之用於非經腸投與之組合物,且將疫苗組合物溶解或懸浮於可接受之載劑(例如水性載劑)中。可使用多種水性載劑,例如水、緩衝水、0.9%鹽水、0.3%甘胺酸、玻尿酸及諸如此類。該等組合物可藉由習用熟知滅菌技術來滅菌,或可經無菌過濾。可將所得水性溶液包裝以供原樣使用或將其凍乾,將凍乾製劑在投與之前與無菌溶液合併。組合物可含有如近似生理條件所需之醫藥上可接受之輔助物質,例如pH調節劑及緩衝劑、張力調節劑、潤濕劑及諸如此類,例如乙酸鈉、乳酸鈉、氯化鈉、氯化鉀、氯化鈣、去水山梨醇單月桂酸酯、三乙醇胺油酸酯等。 新抗原亦可經由脂質體來投與,該等脂質體使該等新抗原靶向具體細胞組織,例如淋巴組織。脂質體亦可用於延長半衰期。脂質體包括乳液、發泡體、膠束、不可溶單層、液晶、磷脂分散液、層狀層及諸如此類。在該等製劑中,欲遞送之新抗原係作為脂質體之一部分單獨或結合其所結合之分子(例如盛行於淋巴樣細胞中之受體,例如結合至CD45抗原之單株抗體)或其他治療或免疫原性組合物納入。因此,可將填充有期望新抗原之脂質體引導至淋巴樣細胞之位點,其中脂質體隨後遞送所選治療/免疫原性組合物。脂質體係自標準囊泡形成脂質形成,該等脂質通常包括中性及帶負電之磷脂及固醇,例如膽固醇。脂質之選擇通常係藉由考慮例如脂質體大小、酸不穩定性及脂質體在血流中之穩定性來指導。多種方法可用於製備脂質體,如例如Szoka等人,Ann. Rev. Biophys. Bioeng. 9; 467 (1980)、美國專利第4,235,871號、第4,501,728號、第4,501,728號、第4,837,028號及第5,019,369號中所述。 為靶向免疫細胞,欲納入脂質體中之配體可包括例如特異性針對期望免疫系統細胞之細胞表面決定子之抗體或其片段。脂質體懸浮液可以靜脈內、局部、外用等方式以根據尤其投與方式、所遞送之肽及所治療疾病之階段變化之劑量來投與。 出於治療或免疫目的,亦可向患者投與編碼肽及視情況本文所述肽中之一或多者之核酸。便捷地使用多種方法將核酸遞送至患者。例如,核酸可作為「裸DNA」直接遞送。此方法闡述於例如Wolff等人,Science 247: 1465-1468 (1990)以及美國專利第5,580,859號及第5,589,466號中。核酸亦可利用如例如美國專利第5,204,253號中所述之彈道遞送來投與。可投與僅包含DNA之粒子。或者,可使DNA黏附至粒子,例如金粒子。用於遞送核酸序列之方法可包括用或不用電穿孔之病毒載體、mRNA載體及DNA載體。 核酸亦可複合遞送至陽離子化合物,例如陽離子脂質。脂質介導之基因遞送方法闡述於例如以下文獻中:9618372WOA WO 96/18372;9324640WOA WO 93/24640;Mannino及Gould-Fogerite, BioTechniques 6(7): 682-691 (1988);美國專利第5,279,833號(Rose)美國專利第5,279,833號;9106309WOA WO 91/06309;及Felgner等人,Proc. Natl. Acad. Sci. USA 84: 7413-7414 (1987)。 新抗原亦可納入基於病毒載體之疫苗平臺中,例如牛痘、雞痘、自我複製α病毒、馬拉巴病毒、腺病毒(例如,參見Tatsis等人,Adenoviruses,Molecular Therapy
(2004) 10, 616-629)或慢病毒屬,包括(但不限於)第二代、第三代或雜合第二代/第三代慢病毒屬及經設計以靶向特定細胞類型或受體之任一代重組慢病毒屬(例如,參見Hu等人,Immunization Delivered by Lentiviral Vectors for Cancer and Infectious Diseases,Immunol Rev.
(2011) 239(1): 45-61;Sakuma等人,Lentiviral vectors: basic to translational,Biochem J.
(2012) 443(3):603-18;Cooper等人,Rescue of splicing-mediated intron loss maximizes expression in lentiviral vectors containing the human ubiquitin C promoter,Nucl . Acids Res.
(2015) 43 (1): 682-690;Zufferey等人,Self-Inactivating Lentivirus Vector for Safe and Efficient In Vivo Gene Delivery,J. Virol.
(1998) 72 (12): 9873-9880)。端視上文所提及基於病毒載體之疫苗平臺之包裝能力,此方法可遞送一或多個編碼一或多種新抗原肽之核苷酸序列。該等序列可側接有非突變序列,可藉由連接體分開或之前可為一或多個靶向亞細胞隔室之序列(例如,參見Gros等人,Prospective identification of neoantigen-specific lymphocytes in the peripheral blood of melanoma patients,Nat Med.
(2016) 22 (4):433-8;Stronen等人,Targeting of cancer neoantigens with donor-derived T cell receptor repertoires,Science.
(2016) 352 (6291):1337-41;Lu等人,Efficient identification of mutated cancer antigens recognized by T cells associated with durable tumor regressions,Clin Cancer Res .
(2014) 20(13):3401-10)。在引入宿主中後,受感染細胞表現新抗原,且由此引發針對肽之宿主免疫(例如,CTL)反應。可用於免疫方案中之牛痘載體及方法闡述於例如美國專利第4,722,848號中。另一載體係BCG (卡介苗)。BCG載體闡述於Stover等人(Nature 351:456-460 (1991))中。熟習此項技術者根據本文描述將明瞭可用於新抗原之治療性投與或免疫之眾多種其他疫苗載體,例如傷寒沙氏桿菌載體及諸如此類。 投與核酸之方式利用編碼一或多個表位之袖珍基因構築體。為產生編碼所選CTL表位(袖珍基因)以在人類細胞中表現之DNA序列,反轉譯表位之胺基酸序列。使用人類密碼子使用表來指導每一胺基酸之密碼子選擇。使該等表位編碼DNA序列直接鄰接,以產生連續多肽序列。為最佳化表現及/或免疫原性,可將其他元件納入袖珍基因設計中。可經反轉譯且納入袖珍基因序列中之胺基酸序列之實例包括:輔助T淋巴球、表位、前導(信號)序列及內質網滯留信號。另外,可藉由納入毗鄰CTL表位之合成(例如聚丙胺酸)或天然側接序列來改良CTL表位之MHC呈遞。藉由組裝編碼袖珍基因之正股及負股之寡核苷酸將袖珍基因序列轉化至DNA。在適宜條件下利用熟知技術合成重疊寡核苷酸(長30-100個鹼基),將其磷酸化,純化且退火。利用T4 DNA連結酶來接合寡核苷酸之末端。然後可將編碼CTL表位多肽之此合成袖珍基因選殖至期望表現載體中。 可使用多種調配來製備經純化之質體DNA用於注射。該等調配中之最簡單者係將凍乾DNA重構於無菌磷酸鹽緩衝鹽水(PBS)中。業內已闡述多種方法,且可使用新技術。如上所述,將核酸便捷地與陽離子脂質調配在一起。另外,亦可將醣酯、促融脂質體、肽及化合物(統稱為保護性、相互作用、非凝聚化合物) (PINC)複合至經純化質體DNA以影響諸如穩定性、肌內分散或至特定器官或細胞類型之輸送等變量。 本文亦揭示製造腫瘤疫苗之方法,其包含以下步驟:實施本文所揭示之方法;及產生包含複數種新抗原或複數種新抗原之亞組之腫瘤疫苗。 本文所揭示之新抗原可利用業內已知之方法來製造。舉例而言,本文所揭示產生新抗原或載體(例如,包括至少一個編碼一或多種新抗原之序列之載體)之方法可包括在適於表現新抗原或載體之條件下培養宿主細胞,其中宿主細胞包含至少一個編碼新抗原或載體之多核苷酸,及純化新抗原或載體。標準純化方法包括層析技術、電泳、免疫、沈澱、透析、過濾、濃縮及層析聚焦技術。 宿主細胞可包括中國倉鼠卵巢(CHO)細胞、NS0細胞、酵母或HEK293細胞。可用一或多種包含至少一個編碼本文所揭示新抗原或載體之核酸序列之多核苷酸來轉換宿主細胞,視情況其中經分離之多核苷酸進一步包含可操作連接至至少一個編碼新抗原或載體之核酸序列之啟動子序列。在某些實施例中,經分離之多核苷酸可為cDNA。VI. 新抗原辨識 VI.A. 新抗原候選者辨識 .
用於腫瘤及正常外顯子體及轉錄體之NGS分析之研究方法已闡述且應用於新抗原辨識領域中。6,14,15
下文實例考慮針對臨床環境中之新抗原辨識具更大靈敏性及特異性之某些最佳化。該等最佳化可分成兩個區域,與實驗室製程相關之彼等及與NGS數據分析相關之彼等。VI.A.1. 實驗室製程最佳化
此處所呈現之製程改良解決了自具有低腫瘤含量及小體積之臨床樣本發現高準確度新抗原的挑戰,此係藉由將對靶向癌症面板中之可靠癌症驅動基因評價研發出之概念16
延伸至為新抗原辨識所需之整個外顯子體及轉錄體環境來達成。特定而言,該等改良包括: 1. 橫跨腫瘤外顯子體靶向深度(>500×)獨特平均覆蓋率以檢測因低腫瘤含量或亞純系狀態所致以低突變體對偶基因頻率存在之突變。 2. 橫跨腫瘤外顯子體靶向均一覆蓋率,其中<5%之鹼基以<100×覆蓋,以使得最少可能的新抗原因例如以下原因而丟失: a. 採用基於DNA之捕獲探針及個別探針QC17
b. 對於較差覆蓋之區域納入其他餌 3. 橫跨正常外顯子體靶向均一覆蓋率,其中<5%之鹼基以<20×覆蓋,以使得最少可能的新抗原保持體細胞/生殖系狀況未分類(且因此不如TSNA有用)。 4. 為最小化所需測序之總量,將僅針對基因之編碼區來設計序列捕獲探針,此乃因非編碼RNA無法產生新抗原。其他最佳化包括: a. HLA基因之補充性探針,其富含GC且被標準外顯子體測序較差捕獲18
b. 排除經預測因諸如不充分表現、蛋白酶體之次最佳消化或不尋常序列特徵等因素產生極少或不產生候選新抗原之基因。 5. 同樣以高深度(>100M讀段(reads))對腫瘤RNA進行測序以實現變體檢測、基因及剪接變體(「異型體」)表現之量化及融合物檢測。將利用基於探針之富集19
、使用與捕獲DNA中之外顯子體所用相同或相似之探針來提取FFPE樣品之RNA。VI.A.2. NGS 數據分析最佳化
分析方法之改良解決了普通研究突變呼叫方法之次最佳靈敏性及特異性,且明確考慮與臨床環境中之新抗原辨識相關之客製化。該等改良包括: 1. 利用HG38參考人類基因體或更高版本進行比對,此乃因其含有較佳反映群體多型性之多個MHC區域總成,此與先前基因體釋放不同。 2. 藉由歸併不同程式之結果.5
克服單一變體呼叫者之限制20
a. 利用一組工具檢測腫瘤DNA、腫瘤RNA及正常DNA之單核苷酸變體及插入/缺失,該組工具包括:基於比較腫瘤DNA與正常DNA之程式,例如Strelka21
及Mutect22
;及納入腫瘤DNA、腫瘤RNA及正常DNA之程式,例如UNCeqR,其在低純度樣品中尤其有利23
。 b. 利用執行局部再組裝之程式(例如Strelka及ABRA24
)來測定插入/缺失。 c. 利用專用工具(例如Pindel25
或Breakseq26
)來測定結構重排。 3. 為檢測且防止樣品調換,以所選多型性位點數比較同一患者之樣品之變體呼叫。 4. 人工呼叫之廣泛過濾將例如藉由以下各項來實施: a. 移除於正常DNA中所發現之變體,可能地在低覆蓋率之情形下使用鬆弛檢測參數,且在插入/缺失之情形下使用容許接近標準 b. 移除因低映射品質或低鹼基品質所致之變體27
c. 移除源自複現性測序假影之變體,即使在相應正常組織中未觀察到27
。實例包括主要在一個股上檢測到之變體。 d. 移除在不相關對照集中檢測到之變體27
5. 利用seq2HLA28
、ATHLATES29
或Optitype中之一者亦及組合外顯子體及RNA測序數據28
自正常外顯子體準確呼叫HLA。其他潛在最佳化包括採取專用HLA分型分析(例如長讀DNA測序30
)或改編接合RNA片段之方法以保持連續性31
。 6. 利用CLASS32
、Bayesembler33
、StringTie34
或類似程式以其參考文獻指導之模式(即,利用已知轉錄本結構而非嘗試自每一實驗再產生其整體轉錄本)藉由根據RNA-seq數據組裝轉錄本來實施源自腫瘤特異性剪接變體之neo-ORF之穩健檢測。儘管Cufflinks35
常用於此目的,但其經常產生難以置信地大量剪接變體,其中之許多遠遠短於全長基因,且可無法重新獲得簡單的陽性對照。使用諸如SpliceR36
及MAMBA37
等工具及再引入之突變體序列來測定編碼序列及無義介導之衰變潛能。使用諸如Cufflinks35
或Express等工具來測定基因表現(Roberts及Pachter, 2013)。使用針對該等目的研發出之工具(例如ASE38
或HTSeq39
)來測定野生型及突變體特異性表現計數及/或相對量。潛在過濾步驟包括: a. 移除視為不充分表現之候選neo-ORF。 b. 移除經預測以觸發無義介導之衰變(NMD)之候選neo-ORF。 7. 根據其他參數、例如藉由考慮以下各項,將僅在RNA中觀察到之無法直接驗證為腫瘤特異性之候選新抗原(例如,neoORF)歸類為可能腫瘤特異性: a. 支持僅腫瘤DNA順式作用框移或剪接位點突變之存在 b. 確證剪接因子中僅腫瘤DNA反式作用突變之存在。例如,在三個使用R625突變體SF3B1之獨立公開實驗中,即使一個實驗檢查葡萄膜黑色素瘤患者40
,第二個實驗檢查葡萄膜黑色素瘤細胞系41
,且第三個實驗檢查乳癌患者42
,但展現最大差別剪接之基因係一致的。 c. 對於新穎剪接異型體,確證RNASeq數據中之「新穎」剪接接合處讀段。 d. 對於新穎重排,確證腫瘤DNA中之在正常DNA中不存在之並置外顯子讀段之存在 e. 不存在於諸如GTEx43
等基因表現編匯中(即,使生殖系來源較不可能) 8. 藉由直接比較組裝的DNA腫瘤與正常讀段(或來自該等讀段之k聚體)來補充基於參考基因體比對之分析以避免基於比對及註解之誤差及假影。(例如對於在生殖系變體附近出現之體細胞變體或重複內容脈絡插入/缺失) 在含有多腺苷酸化RNA之樣品中,利用RNA CoMPASS44
或用於辨識可預測患者反應之其他因素之類似方法來評價RNA-seq數據中病毒及微生物RNA之存在。VI.B. HLA 肽之分離及檢測
在裂解及溶解組織樣品後利用經典免疫沈澱(IP)方法來實施HLA肽分子之分離(55-58)。將澄清裂解物用於HLA特異性IP。 使用偶合至珠粒之抗體來實施免疫沈澱,其中該抗體特異性針對HLA分子。對於泛I類HLA免疫沈澱,使用泛I類CR抗體,對於II類HLA-DR,使用HLA-DR抗體。在過夜培育期間抗體共價附接至NHS-瓊脂糖珠粒。在共價附接後,洗滌珠粒且等分用於IP。(59、60) 將澄清組織裂解物添加至抗體珠粒中用於免疫沈澱。在免疫沈澱後,自裂解物移除珠粒且儲存裂解物用於其他實驗,包括其他IP。洗滌IP珠粒以移除非特異性結合,且利用標準技術自珠粒溶析HLA/肽複合體。利用分子量旋轉管柱或C18分級分離自肽移除蛋白質組份。藉由SpeedVac蒸發使所得肽乾燥且在一些情況下在MS分析之前儲存在-20℃下。 將乾燥肽重構於適於反相層析之HPLC緩衝液中且裝載至C-18微毛細管HPLC管柱上以供在Fusion Lumos質譜儀(Thermo)中進行梯度溶析。在Orbitrap檢測器中在高解析度下收集肽質量/電荷(m/z)之MS1光譜,然後在所選離子之HCD片段化後在離子捕集檢測器中收集MS2低解析度掃描。另外,可使用CID或ETD片段化方法或三種技術之任一組合來獲得MS2光譜以得到肽之較大胺基酸覆蓋率。MS2光譜亦可在Orbitrap檢測器中以高解析度質量準確度來量測。 利用Comet針對蛋白質數據庫檢索每一分析之MS2光譜(61、62)且利用Percolator對肽辨識進行評分(63-65)。VI.B.1. 支持全面 HLA 肽測序之檢測研究之 MS 限值 .
利用肽YVYVADVAAK,使用裝載至LC管柱上之不同量之肽來確定檢測限值。所測試肽之量為1 pmol、100 fmol、10 fmol、1 fmol及100 amol。(表1) 結果顯示於圖1F中。該等結果指示,最低檢測限值(LoD)介於阿莫耳(attomol)範圍內(10-18
),動態範圍跨越5個數量級,且在低飛莫耳(femtomol)範圍(10-15
)下之信號對雜訊似乎足以用於測序。 VII. 呈遞模型 VII.A. 系統概述
圖2A係根據實施例用於辨識患者中之肽呈遞似然度之環境100之概述。環境100提供內容脈絡以引入呈遞辨識系統160,其自身包括呈遞資訊存儲區165。 呈遞辨識系統160係一種以如下文圖14所論述之計算系統體現之電腦模型,其接收與MHC對偶基因集相關之肽序列且確定肽序列將由相關MHC對偶基因集中之一或多者呈遞之似然度。此可用於多個內容脈絡中。呈遞辨識系統160之一個特定使用情形在於,其能夠接收與患者110之腫瘤細胞之MHC對偶基因集相關之候選新抗原114的核苷酸序列,且確定候選新抗原將由腫瘤之一或多個相關MHC對偶基因呈遞及/或誘導患者110之免疫系統中之免疫原性反應的似然度。如藉由系統160所測定具有高似然度之彼等候選新抗原可經選擇以納入疫苗118中,該抗腫瘤免疫反應可自提供腫瘤細胞之患者110之免疫系統引發。 呈遞辨識系統160經由一或多種呈遞模型來測定呈遞似然度。特定而言,呈遞模型產生相關MHC對偶基因集是否呈遞給定肽序列之似然度,且係基於存儲區165中所存儲之呈遞資訊來產生。舉例而言,呈遞模型可產生樣品細胞表面上之對偶基因集HLA-A*02:01、HLA-B*07:02、HLA-B*08:03、HLA-C*01:04、HLA-A*06:03、HLA-B*01:04是否呈遞肽序列「YVYVADVAAK」之似然度。呈遞資訊165含有關於肽是否結合至不同類型之MHC對偶基因使得彼等肽係由MHC對偶基因呈遞之資訊,在該等模型中該呈遞資訊係端視肽序列中胺基酸之位置來確定。呈遞模型可基於呈遞資訊165預測未經識別之肽序列是否與相關MHC對偶基因集一起呈遞。VII.B. 呈遞資訊
圖2圖解說明根據實施例獲得呈遞資訊之方法。呈遞資訊165包括兩大類資訊:對偶基因相互作用資訊及對偶基因非相互作用資訊。對偶基因相互作用資訊包括影響依賴於MHC對偶基因之類型之肽序列呈遞之資訊。對偶基因非相互作用資訊包括影響不依賴於MHC對偶基因之類型之肽序列呈遞之資訊。VII.B.1. 對偶基因相互作用資訊
對偶基因相互作用資訊主要包括已知由一或多個來自人類、小鼠等之經辨識MHC分子呈遞之經辨識肽序列。應注意,此可包括或可不包括自腫瘤樣品獲得之數據。經呈遞肽序列可自表現單一MHC對偶基因之細胞來辨識。在此情形下,經呈遞肽序列通常係自經改造以表現預定MHC對偶基因且隨後暴露於合成蛋白之單一對偶基因細胞系收集。呈遞於MHC對偶基因上之肽係藉由諸如酸溶析等技術來分離且經由質譜來辨識。圖2B顯示此之實例,其中呈遞於預定MHC對偶基因HLA-A*01:01上之實例性肽YEMFNDKS經分離且經由質譜來辨識。由於在此情況下肽係經由經改造以表現單一預定MHC蛋白之細胞來辨識,故明確已知經呈遞肽與其所結合之MHC蛋白之間之直接相關性。 經呈遞肽序列亦可自表現多個MHC對偶基因之細胞收集。通常在人類中,細胞表現6種不同類型之MHC分子。該等經呈遞肽序列可自經改造以表現多個預定MHC對偶基因之多對偶基因細胞系來辨識。該等經呈遞肽序列亦可自組織樣品(正常組織樣品或腫瘤組織樣品)來辨識。在此情形下,具體而言,MHC分子可自正常或腫瘤組織進行免疫沈澱。呈遞於多個MHC對偶基因上之肽可類似地藉由諸如酸溶析等技術來分離且經由質譜來辨識。圖2C顯示此之實例,其中6個實例性肽YEMFNDKSF、HROEIFSHDFJ、FJIEJFOESS、NEIOREIREI、JFKSIFEMMSJDSSU及KNFLENFIESOFI呈遞於經辨識MHC對偶基因HLA-A*01:01、HLA-A*02:01、HLA-B*07:02、HLA-B*08:01、HLA-C*01:03及HLA-C*01:04上且經分離並經由質譜來辨識。與單一對偶基因細胞系不同,經呈遞肽與其所結合之MHC蛋白之間之直接相關性可能未知,此乃因結合肽係在經辨識之前自MHC分子分離。 對偶基因相互作用資訊亦可包括質譜離子流,其取決於肽-MHC分子複合體之濃度及肽之離子化效率二者。離子化效率以序列依賴性方式自肽至肽變化。通常,離子化效率自肽至肽在約兩個數量級內變化,而肽-MHC複合體之濃度在更大範圍內變化。 對偶基因相互作用資訊亦可包括量測或預測給定MHC對偶基因與給定肽之間之結合親和力。一或多種親和力模型可產生該等預測。舉例而言,返回至圖1D中所示之實例,呈遞資訊165可包括肽YEMFNDKSF與對偶基因HLA-A*01:01之間1000 nM之結合親和力預測。IC50 > 1000 nM之極少肽係由MHC呈遞,且較低IC50值增加呈遞之機率。 對偶基因相互作用資訊亦可包括量測或預測MHC複合體之穩定性。一或多種穩定性模型可產生該等預測。更穩定之肽-MHC複合體(即,具有較長半衰期之複合體)更可能以高拷貝數呈遞於遇到疫苗抗原之腫瘤細胞及抗原呈遞細胞上。舉例而言,返回至圖2C中所示之實例,呈遞資訊165可包括對分子HLA-A*01:01之1 h半衰期之穩定性預測。 對偶基因相互作用資訊亦可包括經量測或預測之肽-MHC複合體之形成反應速率。以較高速率形成之複合體更可能以高濃度呈遞於細胞表面上。 對偶基因相互作用資訊亦可包括肽之序列及長度。I類MHC分子通常偏好呈遞長度介於8個與15個肽之間之肽。60%-80%之經呈遞肽具有長度9。來自若干細胞系之經呈遞肽長度之直方圖顯示於圖5中。 對偶基因相互作用資訊亦可包括新抗原編碼肽上激酶序列基序之存在及新抗原編碼肽上特異性轉譯後修飾之不存在或存在。激酶基序之存在影響轉譯後修飾之機率,轉譯後修飾可增強或干擾MHC結合。 對偶基因相互作用資訊亦可包括參與轉譯後修飾過程之蛋白質(例如激酶)之表現量或活性程度(如根據RNAseq、質譜或其他方法所量測或預測)。 對偶基因相互作用資訊亦可包括具有相似序列之肽在表現特定MHC對偶基因之其他個體之細胞中之呈遞機率,如藉由質譜蛋白質體學或其他方式所評價。 對偶基因相互作用資訊亦可包括特定MHC對偶基因在所討論個體中之表現量(例如如藉由RNA-seq或質譜所量測)。最強結合至大量表現之MHC對偶基因之肽比最強結合至少量表現之MHC對偶基因之肽更可能被呈遞。 對偶基因相互作用資訊亦可包括在表現特定MHC對偶基因之其他個體中藉由特定MHC對偶基因呈遞之總體新抗原編碼肽序列非依賴性機率。 對偶基因相互作用資訊亦可包括在其他個體中之同一家族分子(例如,HLA-A、HLA-B、HLA-C、HLA-DQ、HLA-DR、HLA-DP)中MHC對偶基因之總體非肽序列依賴性呈遞機率。舉例而言,HLA-C分子通常係以低於HLA-A或HLA-B分子之量表現,且因此HLA-C對肽之呈遞較不可能優先於HLA-A或HLA-B之呈遞11。 對偶基因相互作用資訊亦可包括特定MHC對偶基因之蛋白質序列。 以下部分中所列示之任何MHC對偶基因非相互作用資訊亦可建模為MHC對偶基因相互作用資訊。VII.B.2. 對偶基因非相互作用資訊
對偶基因非相互作用資訊可包括在其源蛋白序列內側接新抗原編碼肽之C末端序列。C末端側接序列可影響肽之蛋白酶體處理。然而,C末端側接序列在肽轉運至內質網且遇到細胞表面上之MHC對偶基因之前由蛋白酶體自肽裂解。因此,MHC分子不接收關於C末端側接序列之資訊,且因此C末端側接序列之效應無法端視MHC對偶基因類型而變化。舉例而言,返回至圖2C中所示之實例,呈遞資訊165可包括自肽之源蛋白辨識之經呈遞肽FJIEJFOESS之C末端側接序列FOEIFNDKSLDKFJI。 對偶基因非相互作用資訊亦可包括mRNA量化量測。舉例而言,可獲得提供質譜訓練數據之同一樣品之mRNA量化數據。如下文參考圖13H所述,RNA表現經辨識為肽呈遞之強預測子。在一個實施例中,mRNA量化量測係根據軟體工具RSEM來辨識。RSEM軟體工具之詳細執行方案可參見Bo Li及Colin N. Dewey.RSEM: accurate transcript quantification from RNA-Seq data with or without a reference genome. BMC Bioinformatics
, 12:323, 2011年8月。在一個實施例中,mRNA量化係以片段/每千鹼基轉錄本/每百萬映射讀段(FPKM)為單位來量測。 對偶基因非相互作用資訊亦可包括在其源蛋白序列內側接肽之N末端序列。 對偶基因非相互作用資訊亦可包括在肽中存在蛋白酶裂解基序,視情況根據相應蛋白酶在腫瘤細胞中之表現來加權(如藉由RNA-seq或質譜所量測)。含有蛋白酶裂解基序之肽不太可能被呈遞,此乃因其更容易被蛋白酶降解,且因此在細胞內較不穩定。 對偶基因非相互作用資訊亦可包括如在適宜細胞類型中量測之源蛋白之轉換率。較快轉換率(即,較短半衰期)增加呈遞之機率;然而,此特徵之預測力在不相似細胞類型中量測時較低。 對偶基因非相互作用資訊亦可包括源蛋白之長度,視情況考慮在腫瘤細胞中最高表現之特異性剪接變體(「異型體」),如藉由RNA-seq或蛋白質體質譜所量測,或如根據在DNA或RNA序列數據中檢測到之生殖系或體細胞剪接突變之註解所預測。 對偶基因非相互作用資訊亦可包括蛋白酶體、免疫蛋白酶體、胸腺蛋白酶體或其他蛋白酶在腫瘤細胞中之表現量(其可藉由RNA-seq、蛋白質體質譜或免疫組織化學來量測)。不同蛋白酶體具有不同的裂解位點偏好。對於與其表現量成比例之每一類型之蛋白酶體之裂解偏好將給予更大權重。 對偶基因非相互作用資訊亦可包括肽之源基因之表現(例如,如藉由RNA-seq或質譜所量測)。可能的最佳化包括調節所量測之表現以計及腫瘤樣品內存在基質細胞及腫瘤浸潤淋巴球。來自更高表現之基因之肽更可能被呈遞。可不予考慮來自具有無法檢測表現量之基因之肽。 對偶基因非相互作用資訊亦可包括新抗原編碼肽之源mRNA將經歷無義介導之衰變之機率,如藉由無義介導之衰變模型(例如Rivas等人,Science 2015之模型)所預測。 對偶基因非相互作用資訊亦可包括肽之源基因在細胞週期之各個階段期間之典型組織特異性表現。總體上少量表現(如藉由RNA-seq或質譜蛋白質體學所量測)但已知在細胞週期之特定階段期間大量表現之基因可能產生比以極低量穩定表現之基因更多之呈遞肽。 對偶基因非相互作用資訊亦可包括源蛋白之特徵總目,如例如uniProt或PDB http://www.rcsb.org/pdb/home/home.do中所給出。該等特徵尤其可包括:蛋白質之二級及三級結構、亞細胞定位11、基因本體論(GO)術語。特定而言,此資訊可含有在蛋白質層面上起作用之註解(例如5’ UTR長度)及在特定殘基層面上起作用之註解(例如殘基300與310之間之螺旋基序)。該等特徵亦可包括轉角基序、褶疊基序及無序殘基。 對偶基因非相互作用資訊亦可包括闡述含有肽之源蛋白之結構域性質之特徵,例如:二級或三級結構(例如,α螺旋對β褶板);選擇式剪接。 對偶基因非相互作用資訊亦可包括闡述在肽之源蛋白中之肽位置存在或不存在呈遞熱點之特徵。 對偶基因非相互作用資訊亦可包括來自所討論肽之源蛋白之肽在其他個體中之呈遞機率(在調節源蛋白在彼等個體中之表現量及彼等個體之不同HLA類型之影響後)。 對偶基因非相互作用資訊亦可包括因技術偏差無法藉由質譜檢測或過表該肽之機率。 如藉由基因表現分析(例如RNASeq、微陣列、靶向面板(例如Nanostring))所量測之多個基因模組/路徑、或藉由諸如RT-PCR等分析量測之基因模組之單/多基因代表的表現(其無需含有肽之源蛋白),該等基因模組/路徑提供關於腫瘤細胞、基質或腫瘤浸潤淋巴球(TIL)之狀態之資訊。 對偶基因非相互作用資訊亦可包括腫瘤細胞中肽之源基因之拷貝數。舉例而言,來自在腫瘤細胞中經歷同型接合缺失之基因之肽可分配0之呈遞機率。 對偶基因非相互作用資訊亦可包括肽結合至TAP之機率或經量測或預測之肽與TAP之結合親和力。更可能結合至TAP之肽或以較高親和力結合TAP之肽更可能被呈遞。 對偶基因非相互作用資訊亦可包括TAP在腫瘤細胞中之表現量(其可藉由RNA-seq、蛋白質體質譜、免疫組織化學來量測)。較高TAP表現量增加所有肽之呈遞機率。 對偶基因非相互作用資訊亦可包括存在或不存在腫瘤突變,包括(但不限於): i. 在諸如以下等已知癌症驅動基因中之驅動突變:EGFR、KRAS、ALK、RET、ROS1、TP53、CDKN2A、CDKN2B、NTRK1、NTRK2、NTRK3 ii. 在編碼參與抗原呈遞機制之蛋白質之基因(例如,B2M、HLA-A、HLA-B、HLA-C、TAP-1、TAP-2、TAPBP、CALR、CNX、ERP57、HLA-DM、HLA-DMA、HLA-DMB、HLA-DO、HLA-DOA、HLA-DOBHLA-DP、HLA-DPA1、HLA-DPB1、HLA-DQ、HLA-DQA1、HLA-DQA2、HLA-DQB1、HLA-DQB2、HLA-DR、HLA-DRA、HLA-DRB1、HLA-DRB3、HLA-DRB4、HLA-DRB5或編碼蛋白酶體或免疫蛋白酶體之組份之基因中的任一者)中。呈遞依賴於抗原呈遞機制之組份之肽具有減小的呈遞機率,該抗原呈遞機制之組份在腫瘤中經歷功能喪失型突變。 存在或不存在功能生殖系多型性,包括(但不限於):i.
在編碼參與抗原呈遞機制之蛋白質之基因(例如,B2M、HLA-A、HLA-B、HLA-C、TAP-1、TAP-2、TAPBP、CALR、CNX、ERP57、HLA-DM、HLA-DMA、HLA-DMB、HLA-DO、HLA-DOA、HLA-DOBHLA-DP、HLA-DPA1、HLA-DPB1、HLA-DQ、HLA-DQA1、HLA-DQA2、HLA-DQB1、HLA-DQB2、HLA-DR、HLA-DRA、HLA-DRB1、HLA-DRB3、HLA-DRB4、HLA-DRB5或編碼蛋白酶體或免疫蛋白酶體之組份之基因中的任一者)中 對偶基因非相互作用資訊亦可包括腫瘤類型(例如,NSCLC、黑色素瘤)。 對偶基因非相互作用資訊亦可包括HLA對偶基因之已知功能性,如藉由例如HLA對偶基因後綴所反映。舉例而言,對偶基因名稱HLA-A*24:09N中之N後綴指示不表現且因此不可能呈遞表位之無效對偶基因;完整HLA對偶基因後綴命名闡述於https://www.ebi.ac.uk/ipd/imgt/hla/nomenclature/suffixes.html上。 對偶基因非相互作用資訊亦可包括臨床腫瘤亞型(例如,鱗狀肺癌對非鱗狀)。 對偶基因非相互作用資訊亦可包括吸煙史。 對偶基因非相互作用資訊亦可包括曬傷史、日曬史或暴露於其他誘變劑史。 對偶基因非相互作用資訊亦可包括肽之源基因在相關腫瘤類型或臨床亞型中之典型表現,視情況藉由驅動突變分層。通常在相關腫瘤類型中大量表現之基因更可能被呈遞。 對偶基因非相互作用資訊亦可包括所有腫瘤、或相同類型之腫瘤、或具有至少一個共享MHC對偶基因之個體之腫瘤、或具有至少一個共享MHC對偶基因之個體之相同類型之腫瘤中的突變頻率。 在突變腫瘤特異性肽之情形下,用於預測呈遞機率之特徵之列表亦可包括突變(例如,誤義、通讀、框移、融合等)或突變是否經預測產生無義介導之衰變(NMD)之註解。舉例而言,因同型接合早期終止突變而不在腫瘤細胞中轉譯之蛋白質區段之肽可分配0之呈遞機率。NMD使得mRNA轉譯減少,此降低呈遞之機率。VII.C. 呈遞辨識系統
圖3係圖解說明一實施例之呈遞辨識系統160之電腦邏輯組件的高階方塊圖。在此實例性實施例中,呈遞辨識系統160包括數據管控模組312、編碼模組314、訓練模組316及預測模組320。呈遞辨識系統160亦包含訓練數據存儲區170及呈遞模型存儲區175。模型管控系統160之一些實施例具有不同於此處所述彼等之模組。類似地,多種功能可以不同於此處所述之方式分佈在各模組中。VII.C.1. 數據管控模組
數據管控模組312自呈遞資訊165產生多組訓練數據170。每組訓練數據含有複數個數據實例,其中每一數據實例i
含有一組自變數 zi
,其包括至少經呈遞或未經呈遞之肽序列 pi 、
與肽序列 pi
相關之一或多個相關MHC對偶基因 ai
、及代表在預測新自變數值中受關注之呈遞辨識系統160之資訊的應變數yi
。 在本說明書其餘部分通篇中所提及之一具體執行方案中,應變數yi
係指示肽 pi
是否由一或多個相關MHC對偶基因 ai
呈遞之二進制標記。然而,應瞭解,在其他執行方案中,應變數 yi
可代表在端視自變數 zi
預測中受關注之呈遞辨識系統160之任何其他類別之資訊。舉例而言,在另一執行方案中,應變數 yi
亦可為指示針對數據實例辨識之質譜離子流之數值。 針對數據實例 i
之肽序列 pi
係ki
個胺基酸之序列,其中ki
可在一定範圍內之數據實例i
之間變化。舉例而言,對於I類MHC該範圍可為8-15或對於II類MHC該範圍可為9-30。在系統160之一特定執行方案中,訓練數據集中之所有肽序列 pi
可具有相同長度,例如9。肽序列中胺基酸之數量可端視MHC對偶基因之類型(例如,人類等中之MHC對偶基因)而變化。針對數據實例i
之MHC對偶基因 ai
指示存在哪些MHC對偶基因與相應肽序列 pi
相關。 數據管控模組312亦可包括其他對偶基因相互作用變量,例如結合含於訓練數據170中之肽序列 pi
及相關MHC對偶基因 ai
之結合親和力 bi
及穩定性 si
預測。舉例而言,訓練數據170可含有肽 pi
與以 ai
指示之每一相關MHC分子之間的結合親和力預測 bi
。作為另一實例,訓練數據170可含有針對以 ai
指示之每一MHC對偶基因之穩定性預測 si
。 數據管控模組312亦可包括對偶基因非相互作用變量 wi
,例如結合肽序列 pi
之C末端側接序列及mRNA量化量測。 數據管控模組312亦辨識不由MHC對偶基因呈遞之肽序列以產生訓練數據170。通常,此涉及在呈遞之前辨識包括經呈遞肽序列之「較長」源蛋白序列。當呈遞資訊含有經改造細胞系時,數據管控模組312辨識合成蛋白中並不呈遞於細胞之MHC對偶基因上之一系列肽序列,該等細胞暴露於該合成蛋白。當呈遞資訊含有組織樣品時,數據管控模組312辨識經呈遞肽序列所源自之源蛋白,且辨識源蛋白中不呈遞於組織樣品細胞之MHC對偶基因上之一系列肽序列。 數據管控模組312亦可人工產生具有隨機胺基酸序列之肽且將所產生之序列辨識為不呈遞於MHC對偶基因上之肽。此可藉由隨機產生肽序列以允許數據管控模組312容易地產生大量關於不呈遞於MHC對偶基因上之肽之合成數據來實現。由於實際上較小百分比之肽序列係由MHC對偶基因呈遞,故合成產生之肽序列即使納入經細胞處理之蛋白質中亦很可能不會由MHC對偶基因呈遞。 圖4圖解說明一實施例之訓練數據170A之實例性集合。特定而言,訓練數據170A中之前3個數據實例指示涉及對偶基因HLA-C*01:03及3個肽序列QCEIOWARE、FIEUHFWI及FEWRHRJTRUJR之單一對偶基因細胞系之肽呈遞資訊。訓練數據170A中之第四個數據實例指示涉及對偶基因HLA-B*07:02、HLA-C*01:03、HLA-A*01:01及肽序列QIEJOEIJE之多對偶基因細胞系之肽資訊。第一個數據實例指示,肽序列QCEIOWARE並非由對偶基因HLA-C*01:03呈遞。如先前兩段中所論述,肽序列可由數據管控模組312隨機產生或自經呈遞肽之源蛋白來辨識。訓練數據170A亦包括針對肽序列-對偶基因對之1000 nM之結合親和力預測及1 h半衰期之穩定性預測。訓練數據170A亦包括對偶基因非相互作用變量,例如肽FJELFISBOSJFIE之C末端側接序列及102
FPKM之mRNA量化量測。第四個數據實例指示,肽序列QIEJOEIJE係由對偶基因HLA-B*07:02、HLA-C*01:03或HLA-A*01:01中之一者呈遞。訓練數據170A亦包括針對每一對偶基因之結合親和力預測及穩定性預測以及肽之C側接序列及肽之mRNA量化量測。VII.C.2. 編碼模組
編碼模組314將含於訓練數據170中之資訊編碼成可用於產生一或多種呈遞模型之數值表示。在一執行方案中,編碼模組314針對預定20字母胺基酸字母表對序列(例如,肽序列或C末端側接序列)進行獨熱編碼。特定而言,具有ki
個胺基酸之肽序列 pi
表示為20
個ki
元素之列向量,其中在pi 20∙(j-1)+1
, pi 20∙(j-1)+2
, …, pi 20∙j
中對應於肽序列之j-th
位置之胺基酸之字母表的單一元素具有值1。另外,其餘元素具有值0。作為實例,對於給定字母表{A、C、D、E、F、G、H、I、K、L、M、N、P、Q、R、S、T、V、W、Y},針對數據實例i
之3個胺基酸之肽序列EAF可表示為60個元素之列向量 pi
=[0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0]。C末端側接序列 ci
以及MHC對偶基因之蛋白質序列 dh
及呈遞資訊中之其他序列數據可類似地如上文所述來編碼。 當訓練數據170含有不同長度之胺基酸之序列時,編碼模組314可藉由添加PAD字符來延長預定字母表進一步將肽編碼成等長向量。舉例而言,此可藉由用PAD字符左填充肽序列直至肽序列之長度達到具有訓練數據170中之最大長度之肽序列來實施。因此,當具有最大長度之肽序列具有kmax
個胺基酸時,編碼模組314在數值上將每一序列表示為(20+1
)∙kmax
個元素之列向量。作為實例,對於延長字母表{PAD、A、C、D、E、F、G、H、I、K、L、M、N、P、Q、R、S、T、V、W、Y}及kmax
=5
之最大胺基酸長度,3個胺基酸之相同實例性肽序列EAF可表示為105個元素之列向量 pi
=[1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0]。C末端側接序列 ci
或其他序列數據可類似地如上文所述來編碼。因此,肽序列 pi
或 ci
中之每一自變數或欄表示序列特定位置之特定胺基酸之存在。 儘管上述編碼序列數據之方法係參考具有胺基酸序列之序列來闡述,但該方法可類似地延伸至其他類型之序列數據,例如DNA或RNA序列數據及諸如此類。 編碼模組314亦將針對數據實例i
之一或多個MHC對偶基因 ai
編碼為m
個元素之列向量,其中每一元素h=1, 2, …, m
對應於經辨識之獨特MHC對偶基因。對應於針對數據實例i
辨識之MHC對偶基因之元素具有值1。另外,其餘元素具有值0。作為實例,對應於多對偶基因細胞系(其中m=4
種經辨識之獨特MHC對偶基因類型{HLA-A*01:01、HLA-C*01:08、HLA-B*07:02、HLA-C*01:03})之數據實例i
之對偶基因HLA-B*07:02及HLA-C*01:03可表示為4個元素之列向量 ai
=[0 0 1 1],其中a3 i
=1且a4 i
=1。儘管本文闡述具有4種經辨識MHC對偶基因類型之實例,但在實踐中MHC對偶基因類型之數量可為數百或數千。如先前所論述,每一數據實例i
通常含有至多6種與肽序列 pi
相關之不同MHC對偶基因類型。 編碼模組314亦將每一數據實例i
之標記yi
編碼為具有集{0, 1}之值之二進制變量,其中值1指示肽 xi
係由一個相關MHC對偶基因 ai
呈遞,且值0指示肽 xi
並非由任一相關MHC對偶基因 ai
呈遞。當應變數yi
代表質譜離子流時,編碼模組314可另外利用多個函數(例如對於介於[0, ∞]之間之離子流值具有[-∞, ∞]範圍之對數函數)縮放該等值。 編碼模組314可將針對肽pi
及相關MHC對偶基因h
之對偶基因相互作用變量對 xh i
表示為將對偶基因相互作用變量之數值表示依序串聯在一起之列向量。舉例而言,編碼模組314可將 xh i
表示為等於[pi
]
、[pi bh i ] 、 [pi sh i ]
或[pi bh i sh i ]
之列向量,其中bh i
係對肽pi
及相關MHC對偶基因h
之結合親和力預測,且類似地sh i
係穩定性預測。或者,可個別地存儲(例如,作為個別向量或矩陣)對偶基因相互作用變量之一或多種組合。 在一實例中,編碼模組314藉由將經量測或預測之結合親和力值納入對偶基因相互作用變量 xh i
中來表示結合親和力資訊。 在一實例中,編碼模組314藉由將經量測或預測之結合穩定性值納入對偶基因相互作用變量 xh i
中來表示結合穩定性資訊。 在一實例中,編碼模組314藉由將經量測或預測之結合速率值納入對偶基因相互作用變量 xh i
中來表示結合速率資訊。 在一實例中,編碼模組314將肽長度表示為向量 Tk
=[𝟙(Lk
=8) 𝟙(Lk
=9) 𝟙(Lk
=10) 𝟙(Lk
=11) 𝟙(Lk
=12) 𝟙(Lk
=13) 𝟙(Lk
=14) 𝟙(Lk
=15)],其中𝟙係指示函數,且Lk
表示肽 pk
之長度。向量 Tk
可包括在對偶基因相互作用變量 xh i
中。 在一實例中,編碼模組314藉由將MHC對偶基因之基於RNA-seq之表現量納入對偶基因相互作用變量 xh i
中來表示MHC對偶基因之RNA表現資訊。 類似地,編碼模組314可將對偶基因非相互作用變量 wi
表示為將對偶基因非相互作用變量之數值表示依序串聯在一起之列向量。舉例而言, wi
可為等於[ci
]
或[ci mi wi
]
之列向量,其中 wi
係表示除肽 pi
之C端側接序列及與該肽相關之mRNA量化量測 mi
外之任何其他對偶基因非相互作用變量之列向量。或者,可個別地存儲(例如作為個別向量或矩陣)對偶基因非相互作用變量之一或多種組合。 在一個實例中,編碼模組314藉由將轉換率或半衰期納入對偶基因非相互作用變量 wi
中來表示肽序列之源蛋白轉換率。 在一個實例中,編碼模組314藉由將蛋白質長度納入對偶基因非相互作用變量 wi
中來表示源蛋白或異型體之長度。 在一個實例中,編碼模組314藉由將免疫蛋白酶體特異性蛋白酶體亞單位(包括β1 i
、β2 i
、β5 i
亞單位)之平均表現納入對偶基因非相互作用變量 wi
中來表示免疫蛋白酶體之活化。 在一個實例中,編碼模組314表示肽之源蛋白之RNA-seq豐度,或肽之基因或轉錄本(藉由諸如RSEM等技術以FPKM、TPM為單位來量化)可將源蛋白之豐度納入對偶基因非相互作用變量 wi
中。 在一個實例中,編碼模組314表示肽來源之轉錄本將經歷無義介導衰變(NMD)之機率,如藉由例如Rivas等人Science,
2015中之模型所估計,藉由將此機率納入對偶基因非相互作用變量 wi
中。 在一個實例中,編碼模組314表示經由RNA-seq所評估之基因模組或路徑之活化狀況,其係藉由例如對路徑中之每一基因使用例如RSEM以TPM為單位量化路徑中基因之表現,然後計算路徑中之基因之概括統計量(例如平均值)來實施。可將平均值納入對偶基因非相互作用變量 wi
中。 在一個實例中,編碼模組314藉由將拷貝數納入對偶基因非相互作用變量 wi
中來表示源基因之拷貝數。 在一實例中,編碼模組314藉由將經量測或預測之TAP結合親和力(例如,以奈莫耳單位表示)納入對偶基因非相互作用變量 wi
中來表示TAP結合親和力。 在一實例中,編碼模組314藉由將藉由RNA-seq量測(且藉由例如RSEM以TPM為單位量化)之TAP表現量納入對偶基因非相互作用變量 wi
中來表示TAP表現量。 在一實例中,編碼模組314將腫瘤突變表示為對偶基因非相互作用變量 wi
中之指示變量之向量(即,若肽 pk
來自具有KRAS G12D突變之樣品則 dk
= 1,否則 dk
= 0)。 在一實例中,編碼模組314將抗原呈遞基因之生殖系多型性表示為指示變量之向量(即,若肽 pk
來自具有TAP中之特定生殖系多型性之樣品,則 dk
= 1)。可將該等指示變量納入對偶基因非相互作用變量 wi
中。 在一實例中,編碼模組314將腫瘤類型表示為針對腫瘤類型(例如,NSCLC、黑色素瘤、結腸直腸癌等)之字母表之長度1獨熱編碼向量。可將該等獨熱編碼變量納入對偶基因非相互作用變量 wi
中。 在一實例中,編碼模組314藉由用不同後綴處理4數位HLA對偶基因來表示MHC對偶基因後綴。舉例而言,出於該模型之目的,HLA-A*24:09N視為與HLA-A*24:09不同之對偶基因。或者,N後綴之MHC對偶基因對所有肽之呈遞機率可設定為0,此乃因以N後綴結尾之HLA對偶基因不表現。 在一實例中,編碼模組314將腫瘤亞型表示為針對腫瘤亞型(例如,肺腺癌、肺鱗狀細胞癌等)之字母表之長度1獨熱編碼向量。可將該等獨熱編碼變量納入對偶基因非相互作用變量 wi
中。 在一實例中,編碼模組314將吸煙史表示為二進制指示變量(若患者具有吸煙史則 dk
= 1,否則 dk
= 0),其可納入對偶基因非相互作用變量 wi
中。或者,吸煙史可編碼為針對吸煙嚴重程度之字母表之長度1獨熱編碼變量。舉例而言,可將吸煙狀況分級成1-5級,其中1指示不吸煙者,且5指示當前重度吸煙者。由於吸煙史主要與肺腫瘤相關,當對多個腫瘤類型訓練模型時,若患者具有吸煙史且腫瘤類型係肺腫瘤,則此變量亦可定義為等於1,否則定義為等於0。 在一實例中,編碼模組314將曬傷史表示為二進制指示變量(若患者具有嚴重曬傷史則 dk
= 1,否則 dk
= 0),其可納入對偶基因非相互作用變量 wi
中。由於嚴重曬傷主要與黑色素瘤相關,當對多個腫瘤類型訓練模型時,若患者具有嚴重曬傷史且腫瘤類型係黑色素瘤,則此變量亦可定義為等於1,否則定義為等於0。 在一實例中,編碼模組314藉由利用諸如TCGA等參考數據庫將用於人類基因體中每一基因或轉錄本之具體基因或轉錄本之表現量分佈表示為表現量分佈之概括統計量(例如平均值、中值)。特定而言,對於具有腫瘤類型黑色素瘤之樣品中之肽 pk
,不僅可將肽 pk
來源之基因或轉錄本之經量測基因或轉錄本表現量納入對偶基因非相互作用變量 wi
中,且亦納入黑色素瘤中肽 pk
來源之基因或轉錄本之平均值及/或中值基因或轉錄本表現,如藉由TCGA所量測。 在一實例中,編碼模組314將突變類型表示為針對突變類型(例如,誤義、框移、NMD誘導等)之字母表之長度1獨熱編碼變量。可將該等獨熱編碼變量納入對偶基因非相互作用變量 wi
中。 在一實例中,編碼模組314將蛋白質之蛋白質層級特徵表示為對偶基因非相互作用變量 wi
中源蛋白之註解值(例如,5’ UTR長度)。在另一實例中,編碼模組314藉由將指示變量納入對偶基因非相互作用變量 wi
中來表示肽 pk
之源蛋白之殘基層級註解,若肽 pk
與螺旋基序重疊則該指示變量等於1,否則等於0,或若肽 pk
完全含於螺旋基序內則該指示變量等於1。在另一實例中,可將表示含於螺旋基序註解內之肽 pk
中之殘基比例之特徵納入對偶基因非相互作用變量 wi
中。 在一實例中,編碼模組314將人類蛋白質體中之蛋白質或異型體之類型表示為指示向量 ok
,其具有等於人類蛋白質體中之蛋白質或異型體數量之長度,且若肽 pk
來自蛋白質i
則相應元素ok i
為1,否則ok i
為0。 編碼模組314亦可將針對肽 pi
及相關MHC對偶基因h
之變量 zi
之總集表示為將對偶基因相互作用變量 xi
及對偶基因非相互作用變量 wi
之數值表示依序串聯在一起之列向量。舉例而言,編碼模組314可將 zh i
表示為等於[xh i wi
]
或[wi
xh i
]
之列向量。VIII. 訓練模組
訓練模組316構築一或多種產生肽序列是否將由與該等肽序列相關之MHC對偶基因呈遞之似然度的呈遞模型。特定而言,給定肽序列 pk
及與肽序列 pk
相關之一組MHC對偶基因 ak
,每一呈遞模型產生估計uk
,其指示肽序列 pk
將由一或多個相關MHC對偶基因 ak
呈遞之似然度。VIII.A. 概述
訓練模組316基於自存儲於165中之呈遞資訊產生之存儲於存儲區170中之訓練數據集構築另一呈遞模型。通常,無論呈遞模型之特定類型如何,所有呈遞模型皆捕獲訓練數據170中之自變數與應變數之間之依賴性,使得損失函數最小化。特定而言,損失函數𝓁(yi ∈ S , ui ∈ S
; θ
)表示訓練數據170中一或多個數據實例S
之應變數yi ∈ S
值與由呈遞模型產生之對數據實例S
估計之似然度ui ∈ S
之間的差異。在本說明書其餘部分通篇中所提及之一具體執行方案中,損失函數(yi ∈ S , ui ∈ S
; θ
)係藉由如下方程式(1a)給出之負對數似然度函數:然而,在實踐中,可使用另一損失函數。舉例而言,當對質譜離子流進行預測時,損失函數係藉由如下方程式1b給出之均方損失:呈遞模型可為其中一或多個參數 θ
以數學方式指定自變數與應變數之間之依賴性之參數模型。通常,參數型呈遞模型之最小化損失函數(yi ∈ S , ui ∈ S
; θ
)之各個參數係經由基於梯度之數值最佳化演算法(例如批梯度演算法、隨機梯度演算法及諸如此類)來確定。或者,呈遞模型可為其中模型結構係根據訓練數據170來確定且並不嚴格基於固定參數集之非參數模型。VIII.B. 每一對偶基因模型
訓練模組316可構築呈遞模型以基於每一對偶基因來預測肽之呈遞似然度。在此情形中,訓練模組316可基於自表現單一MHC對偶基因之細胞產生之訓練數據170中之數據實例S
來訓練呈遞模型。 在一執行方案中,訓練模組316藉由下式對針對特定對偶基因h
之肽 pk
估計之呈遞似然度uk
建模:其中肽序列 xh k
表示針對肽 pk
及相應MHC對偶基因h
之經編碼對偶基因相互作用變量,f
(∙)係任一函數,且為便於描述在本文通篇中稱為轉換函數。此外,gh
(∙)係任一函數,且為便於描述在本文通篇中稱為依賴性函數,且基於對MHC對偶基因h
確定之參數集 θh
產生對偶基因相互作用變量 xh k
之依賴性評分。每一MHC對偶基因h
之參數集 θh
之值可藉由針對 θh
最小化損失函數來測定,其中i
係自表現單一MHC對偶基因h
之細胞產生之訓練數據170之子集S
中的每一實例。 依賴性函數gh
( xh k
;θh
)之輸出表示MHC對偶基因h
之依賴性評分,其指示MHC對偶基因h
是否將基於至少對偶基因相互作用特徵 xh k
、且具體而言基於肽 pk
之肽序列之胺基酸位置來呈遞相應新抗原。舉例而言,若MHC對偶基因h
可能呈遞肽 pk
則MHC對偶基因h
之依賴性評分可具有高值,且若呈遞係不可能的則MHC對偶基因h
之依賴性評分可具有低值。在此情形下,轉換函數f
(∙)轉換輸入,且更特定而言,將由gh
( xh k
; θh
)產生之依賴性評分轉換成適宜值以指示肽 pk
將由MHC對偶基因呈遞之似然度。 在本說明書其餘部分通篇中所提及之一具體執行方案中,f
(∙)係對於適宜域範圍具有[0, 1]內之範圍之函數。在一實例中,f
(∙)係藉由下式給出之expit函數:作為另一實例,當域z
之值等於或大於0時,f
(∙)亦可為藉由下式給出之雙曲正切函數:。 或者,當對具有範圍[0, 1]外之值之質譜離子流進行預測時,f
(∙)可為任一函數,例如恒等函數、指數函數、對數函數及諸如此類。 因此,肽序列 pk
將由MHC對偶基因h
呈遞之每一對偶基因似然度可藉由以下方式來產生:將MHC對偶基因h之依賴性函數gh
(∙)應用於肽序列 pk
之編碼形式以產生相應依賴性評分。可藉由轉換函數f
(∙)轉換依賴性評分以產生肽序列 pk
將由MHC對偶基因h
呈遞之每一對偶基因似然度。VIII.B.1 對偶基因相互作用變量之依賴性函數
在本說明書通篇所提及之一具體執行方案中,依賴性函數gh
(∙)係藉由下式給出之仿射函數:其將 xh k
中之每一對偶基因相互作用變量與對相關MHC對偶基因h
確定之參數集 θh
中之相應參數線性組合在一起。 在本說明書通篇所提及之另一具體執行方案中,依賴性函數 gh (∙)
係藉由下式給出之網路函數:其表示為具有排列在一或多個層中之一系列結點之網路模型NNh
(∙)。結點可經由各自具有參數集 θh
中之相關參數之連接連接至其他結點。一個具體結點處之值可表示為由與具體結點相關之激活函數所映射之相關參數加權之連接至具體結點之結點值之和。與仿射函數不同,網路模型有利之原因在於,呈遞模型可納入具有不同長度之胺基酸序列之非線性及過程數據。特定而言,經由非線性建模,網路模型可捕獲肽序列中不同位置之胺基酸之間的相互作用及此相互作用如何影響肽呈遞。 一般而言,網路模型NNh
(∙)可結構化為前饋網路,例如人工神經網路(ANN)、捲積神經網路(CNN)、深度神經網路(DNN)及/或遞歸網路,例如長短時記憶網路(LSTM)、二維遞歸網路、深度二維遞歸網路及諸如此類。 在本說明書通篇所提及之一實例中,h=1,2,…, m
中之每一MHC對偶基因與單獨網路模型相關,且NNh
(∙)表示來自與MHC對偶基因h
相關之網路模型之輸出。 圖5圖解說明與任意MHC對偶基因h=
3相關之實例性網路模型NN3
(∙)。如圖5中所示,MHC對偶基因h=3
之網路模型NN3
(∙)包括層l=1
處之三個輸入結點、層l=2
處之四個結點、層l=3
處之兩個結點及層l=4
處之一個輸出結點。
網路模型NN3
(∙)與10參數集θ3
(1), θ3
(2), …, θ3
(10)相關。網路模型NN3
(∙)接收MHC對偶基因h=3
之三個對偶基因相互作用變量x3 k
(1)、x3 k
(2)及x3 k
(3)之輸入值(個別數據實例包括經編碼多肽序列數據及所用之任何其他訓練數據)且輸出值NN3
(x3 k
)。
在另一實例中,經辨識MHC對偶基因h=1, 2, …, m
與單一網路模型NNH
(∙)相關,且NNh
(∙)表示與MHC對偶基因h
相關之單一網路模型之一或多個輸出。在該實例中,參數集 θh
可對應於單一網路模型之參數集,且因此參數集 θh
可為所有MHC對偶基因共享。 圖6A圖解說明為MHC對偶基因h=1,2, …,m
所共享之實例性網路模型NNH
(∙)。如圖6A中所示,網路模型NNH
(∙)包括各自對應於MHC對偶基因之m
個輸出結點。網路模型NN3
(∙)接收MHC對偶基因h=3
之對偶基因相互作用變量 x3 k
且輸出m
值,包括對應於MHC對偶基因h=3
之值NN3
(x3 k
)。 在另一實例中,給定對偶基因相互作用變量 xh k
及MHC對偶基因h
之經編碼蛋白質序列 dh
,單一網路模型NNH
(∙)可為輸出依賴性評分之網路模型。在該實例中,參數集 θh
亦可對應於單一網路模型之參數集,且因此參數集 θh
可為所有MHC對偶基因共享。因此,在該實例中,給予單一網路模型輸入[ xh k
dh
]
,NNh
(∙)可表示單一網路模型NNH
(∙)之輸出。該網路模型有利之原因在於,在訓練數據中未知之MHC對偶基因之肽呈遞機率可僅藉由辨識其蛋白質序列來預測。 圖6B圖解說明為MHC對偶基因所共享之實例性網路模型NNH
(∙)。如圖6B中所示,網路模型NNH
(∙)接收MHC對偶基因h=3
之對偶基因相互作用變量及蛋白質序列作為輸入,且輸出對應於MHC對偶基因h=3
之依賴性評分NN3
(x3 k
)。 在另一實例中,依賴性函數 gh (∙)
可表示為:其中g’h
( xh k
; θ’h
)係具有參數集 θ’h
之仿射函數、網路函數或諸如此類,其中MHC對偶基因之對偶基因相互作用變量之參數集中之偏差參數 θh 0
代表MHC對偶基因h
之基線呈遞機率。 在另一執行方案中,偏差參數 θh 0
可根據MHC對偶基因h
之基因家族來共享。亦即,MHC對偶基因h
之偏差參數 θh 0
可等於 θ 基因 (h) 0
,其中基因
(h
)係MHC對偶基因h
之基因家族。舉例而言,MHC對偶基因HLA-A*02:01、HLA-A*02:02及HLA-A*02:03可分配至「HLA-A」之基因家族,且可共享該等MHC對偶基因中每一者之偏差參數 θh 0
。 返回至方程式(2),作為實例,肽 pk
將由MHC對偶基因h=3
呈遞之似然度(其中m=4
個不同的經辨識MHC對偶基因)可利用仿射依賴性函數gh
(∙)藉由下式來產生:, 其中 x3 k
係MHC對偶基因h=3
之經辨識對偶基因相互作用變量,且 θ3
係經由損失函數最小化對MHC對偶基因h=3
確定之參數集。 作為另一實例,肽 pk
將由MHC對偶基因h=3
呈遞之似然度(其中m=4
個不同的經辨識MHC對偶基因)可利用單獨網路轉換函數gh
(∙)藉由下式來產生:, 其中 x3 k
係MHC對偶基因h=3
之經辨識對偶基因相互作用變量,且 θ3
係對與MHC對偶基因h=3
相關之網路模型NN3
(∙)確定之參數集。 圖7圖解說明利用實例性網路模型NN3
(∙)產生與MHC對偶基因h=
3相關之肽 pk
之呈遞似然度。如圖7中所示,網路模型NN3
(∙)接收MHC對偶基因h=3
之對偶基因相互作用變量 x3 k
且產生輸出NN3
( x3 k
)。輸出係藉由函數 f (∙)
來映射以產生所估計之呈遞似然度uk
。VIII.B.2. 具有對偶基因非相互作用變量之每一對偶基因模型
在一執行方案中,訓練模組316納入對偶基因非相互作用變量且藉由下式對所估計之肽 pk
之呈遞似然度uk
建模:其中 wk
表示肽 pk
之經編碼對偶基因非相互作用變量,gw
(∙)係基於對對偶基因非相互作用變量確定之參數集 θw
之對偶基因非相互作用變量 wk
之函數。特定而言,每一MHC對偶基因h
之參數集 θh
及對偶基因非相互作用變量之參數集 θw
的值可藉由針對 θh
及 θw
最小化損失函數來確定,其中i
係自表現單一MHC對偶基因之細胞產生之訓練數據170之子集S
中的每一實例。 依賴性函數gw
( wk
;θw
)之輸出表示對偶基因非相互作用變量之依賴性評分,其指示基於對偶基因非相互作用變量之影響,肽 pk
是否將由一或多個MHC對偶基因呈遞。舉例而言,若肽 pk
與已知積極地影響肽 pk
之呈遞之C末端側接序列相關,則對偶基因非相互作用變量之依賴性評分可具有高值,且若肽 pk
與已知消極地影響肽 pk
之呈遞之C末端側接序列相關,則對偶基因非相互作用變量之依賴性評分可具有低值。 根據方程式(8),肽序列 pk
將由MHC對偶基因h
呈遞之每一對偶基因似然度可藉由以下方式來產生:將MHC對偶基因h
之函數gh
(∙)應用於肽序列 pk
之編碼形式以產生對偶基因相互作用變量之相應依賴性評分。亦將對偶基因非相互作用變量之函數gw
(∙)應用於對偶基因非相互作用變量之編碼形式以產生對偶基因非相互作用變量之依賴性評分。組合兩個評分,且藉由轉換函數f
(∙)轉換經組合評分以產生肽序列 pk
將由MHC對偶基因h
呈遞之每一對偶基因似然度。 或者,訓練模組316可藉由將對偶基因非相互作用變量 wk
添加至方程式(2)中之對偶基因相互作用變量 xh k
將對偶基因非相互作用變量 wk
納入預測中。因此,呈遞似然度可藉由下式給出: VIII.B.3 對偶基因非相互作用變量之依賴性函數
與對偶基因相互作用變量之依賴性函數gh
(∙)類似,對偶基因非相互作用變量之依賴性函數gw
(∙)可為其中單獨網路模型與對偶基因非相互作用變量 wk
相關之仿射函數或網路函數。 特定而言,依賴性函數gw
(∙)係藉由下式給出之仿射函數:. 其將 wk
中之對偶基因非相互作用變量與參數集 θw
中之相應參數線性組合在一起。 依賴性函數 gw (∙)
亦可為藉由下式給出之網路函數:. 其表示為具有參數集 θw
中之相關參數之網路模型NNw
(∙)。 在另一實例中,對偶基因非相互作用變量之依賴性函數 gw (∙)
可藉由下式給出:其中g’w
( wk
; θ’w
)係仿射函數、具有對偶基因非相互作用參數集 θ’w
之網路函數或諸如此類,mk
係肽 pk
之mRNA量化量測,h
(∙)係轉換量化量測之函數,且θw m
係對偶基因非相互作用變量之參數集中與mRNA量化量測組合以產生mRNA量化量測之依賴性評分之參數。在本說明書其餘部分通篇所提及之一具體實施例中,h
(∙)係對數函數,然而在實踐中h
(∙)可為多種不同函數中之任一者。 在另一實例中,對偶基因非相互作用變量之依賴性函數 gw (∙)
可藉由下式給出:其中g’w
( wk
; θ’w
)係仿射函數、具有對偶基因非相互作用參數集 θ’w
之網路函數或諸如此類, ok
係上文所述針對肽 pk
之代表人類蛋白質體中之蛋白質及異型體之指示向量,且 θw o
係對偶基因非相互作用變量之參數集中與指示向量組合之參數集。在一種變化形式中,當 ok
之維數及參數集 θw o
顯著較高時,當確定參數之值時,可將參數正則化術語(例如,其中||∙||表示L1範數、L2範數、組合或諸如此類)添加至損失函數中。超參數λ之最佳值可經由適當方法來確定。 返回至方程式(8),作為實例,肽 pk
將由MHC對偶基因h=3
呈遞之似然度(其中m=4
個不同的經辨識MHC對偶基因)可利用仿射轉換函數gh
(∙)、gw
(∙)藉由下式來產生:, 其中 wk
係針對肽 pk
之經辨識對偶基因非相互作用變量,且 θw
係對對偶基因非相互作用變量確定之參數集。 作為另一實例,肽 pk
將由MHC對偶基因h=3
呈遞之似然度(其中m=4
個不同的經辨識MHC對偶基因)可利用網路轉換函數gh
(∙)、gw
(∙)藉由下式來產生:其中 wk
係針對肽 pk
之經辨識對偶基因相互作用變量,且 θw
係對對偶基因非相互作用變量確定之參數集。 圖8圖解說明利用實例性網路模型NN3
(∙)及NNw
(∙)產生與MHC對偶基因h=
3相關之肽 pk
之呈遞似然度。如圖8中所示,網路模型NN3
(∙)接收MHC對偶基因h=3
之對偶基因相互作用變量 x3 k
且產生輸出NN3
( x3 k
)。網路模型NNw
(∙)接收針對肽 pk
之對偶基因非相互作用變量 wk
且產生輸出NNw
( wk
)。將輸出組合且藉由函數f
(∙)映射以產生所估計之呈遞似然度uk
。VIII.C. 多對偶基因模型
訓練模組316亦可構築呈遞模型來預測在存在兩個或更多個MHC對偶基因之多對偶基因環境中肽之呈遞似然度。在此情形中,訓練模組316可基於自表現單一MHC對偶基因之細胞、表現多個MHC對偶基因之細胞或其組合產生之訓練數據170中之數據實例S
來訓練呈遞模型。VIII.C.1. 實例 1 :每一對偶基因模型之最大值
在一執行方案中,如上文結合方程式(2)-(11)所述,訓練模組316將與多個MHC對偶基因集H
相關之肽 pk
之所估計呈遞似然度uk
建模為對基於表現單一對偶基因之細胞測定之集H
中之每一MHC對偶基因h
確定之呈遞似然度之函數uk h ∈ H
。特定而言,呈遞似然度uk
可為uk h ∈ H
之任一函數。在一執行方案中,如方程式(12)中所示,該函數係最大值函數,且呈遞似然度uk
可測定為集H
中之每一MHC對偶基因h
之呈遞似然度之最大值。 VIII.C.2. 實例 2.1 :相加函數模型
在一執行方案中,訓練模組316藉由下式對所估計之肽 pk
之呈遞似然度uk
建模:其中對於與肽序列 pk
相關之多個MHC對偶基因H
元素ah k
為1,且 xh k
表示肽 pk
及相應MHC對偶基因之經編碼對偶基因相互作用變量。每一MHC對偶基因h
之參數集 θh
之值可藉由針對 θh
最小化損失函數來確定,其中i
係自表現單一MHC對偶基因之細胞及/或表現多個MHC對偶基因之細胞產生之訓練數據170之子集S
中的每一實例。依賴性函數 gh
可呈上文在部分VIII.B.1中所引入之任一依賴性函數 gh
形式。 根據方程式(13),肽序列 pk
將由一或多個MHC對偶基因h
呈遞之呈遞似然度可藉由以下方式來產生:將依賴性函數gh
(∙)應用於針對MHC對偶基因H
中每一者之肽序列 pk
之經編碼形式以產生對偶基因相互作用變量之相應評分。將每一MHC對偶基因h
之評分組合,且藉由轉換函數f
(∙)轉換以產生肽序列 pk
將由MHC對偶基因集H
呈遞之呈遞似然度。 方程式(13)之呈遞模型與方程式(2)之每一對偶基因模型之不同之處在於,針對每一肽 pk
之相關對偶基因之數量可大於1。換言之,對於與肽序列 pk
相關之多個MHC對偶基因H
,在ah k
中一個以上之元素可具有值1。 作為實例,肽 pk
將由MHC對偶基因h=2 、 h=3
呈遞之似然度(其中m=4
後不同的經辨識MHC對偶基因)可利用仿射轉換函數gh
(∙)藉由下式來產生:, 其中 x2 k 、 x3 k
係針對MHC對偶基因h=2 、 h=3
之經辨識對偶基因相互作用變量,且 θ2 、 θ3
係對MHC對偶基因h=2 、 h=3
確定之參數集。 作為另一實例,肽 pk
將由MHC對偶基因h=2 、 h=3
呈遞之似然度(其中m=4
個不同的經辨識MHC對偶基因)可利用網路轉換函數gh
(∙)、gw
(∙)藉由下式來產生:, 其中NN2
(∙) 、 NN3
(∙)係MHC對偶基因h=2, h=3
之經辨識網路模型,且 θ2 、 θ3
係對MHC對偶基因h=2 、 h=3
確定之參數集。 圖9圖解說明利用實例性網路模型NN2
(∙)及NN3
(∙)產生與MHC對偶基因h=
2、h=
3相關之肽 pk
之呈遞似然度。如圖9中所示,網路模型NN2
(∙)接收MHC對偶基因h=2
之對偶基因相互作用變量 x2 k
並產生輸出NN2
( x2 k
),且網路模型NN3
(∙)接收MHC對偶基因h=3
之對偶基因相互作用變量 x3 k
並產生輸出NN3
( x3 k
)。將輸出組合且藉由函數f
(∙)映射以產生所估計之呈遞似然度uk
。VIII.C.3. 實例 2.2 :具有對偶基因非相互作用變量之相加函數模型
在一執行方案中,訓練模組316納入對偶基因非相互作用變量且藉由下式對所估計之肽 pk
之呈遞似然度uk
建模:其中 wk
表示肽 pk
之經編碼對偶基因非相互作用變量。特定而言,每一MHC對偶基因h
之參數集 θh
及對偶基因非相互作用變量之參數集 θw
的值可藉由針對 θh
及 θw
最小化損失函數來確定,其中i
係自表現單一MHC對偶基因之細胞及/或表現多個MHC對偶基因之細胞產生之訓練數據170中之子集S
的每一實例。依賴性函數 gw
可呈上文在部分VIII.B.3中所引入之任一依賴性函數 gw
形式。 因此,根據方程式(14),肽序列 pk
將由一或多個MHC對偶基因H
呈遞之呈遞似然度可藉由以下方式來產生:將函數gh
(∙)應用於針對MHC對偶基因H
中每一者之肽序列 pk
之經編碼形式以產生針對每一MHC對偶基因h
之對偶基因相互作用變量之相應依賴性評分。亦將對偶基因非相互作用變量之函數gw
(∙)應用於對偶基因非相互作用變量之經編碼形式以產生對偶基因非相互作用變量之依賴性評分。將評分組合,且藉由轉換函數f
(∙)轉換經組合評分以產生肽序列 pk
將由MHC對偶基因H
呈遞之呈遞似然度。 在方程式(14)之呈遞模型中,針對每一肽 pk
之相關對偶基因之數量可大於1。換言之,對於與肽序列 pk
相關之多個MHC對偶基因H
,在ah k
中一個以上之元素可具有值1。 作為實例,肽 pk
將由MHC對偶基因h=2 、 h=3
呈遞之似然度(其中m=4
個不同的經辨識MHC對偶基因)可利用仿射轉換函數gh
(∙)、gw
(∙)藉由下式來產生:, 其中 wk
係針對肽 pk
之經辨識對偶基因非相互作用變量,且 θw
係對對偶基因非相互作用變量確定之參數集。 作為另一實例,肽 pk
將由MHC對偶基因h=2 、 h=3
呈遞之似然度(其中m=4
個不同的經辨識MHC對偶基因)可利用網路轉換函數gh
(∙)、gw
(∙)藉由下式來產生:其中 wk
係針對肽 pk
之經辨識對偶基因相互作用變量,且 θw
係對對偶基因非相互作用變量確定之參數集。 圖10圖解說明利用實例性網路模型NN2
(∙)、NN3
(∙)及NNw
(∙)產生與MHC對偶基因h=2 、 h=
3相關之肽 pk
之呈遞似然度。如圖10中所示,網路模型NN2
(∙)接收針對MHC對偶基因h=2
之對偶基因相互作用變量 x2 k
且產生輸出NN2
( x2 k
)。網路模型NN3
(∙)接收針對MHC對偶基因h=3
之對偶基因相互作用變量 x3 k
且產生輸出NN3
( x3 k
)。網路模型NNw
(∙)接收針對肽 pk
之對偶基因非相互作用變量 wk
且產生輸出NNw
( wk
)。將輸出組合且藉由函數f
(∙)映射以產生所估計之呈遞似然度uk
。 或者,訓練模組316可藉由將對偶基因非相互作用變量 wk
添加至方程式(15)中之對偶基因相互作用變量 xh k
中將對偶基因非相互作用變量 wk
納入預測中。因此,呈遞似然度可藉由下式給出: VIII.C.4. 實例 3.1 :利用內含每一對偶基因似然度之模型
在另一執行方案中,訓練模組316藉由下式對所估計之肽 pk
之呈遞似然度uk
建模:其中對於與肽序列 pk
相關之多個MHC對偶基因h ∈ H
,元素ah k
為1,u’k h
係MHC對偶基因h
之內含每一對偶基因呈遞似然度,向量 v
係元素vh
對應於ah k
∙u’k h
之向量,s
(∙)係映射 v
之元素之函數,且r
(∙)係將輸入之值修剪至給定範圍內之修剪函數。如下文更詳細闡述,s
(∙)可為集成函數或二階函數,但應瞭解在其他實施例中,s
(∙)可為諸如最大值函數等任一函數。內含每一對偶基因似然度之參數集 θ
之值可藉由針對 θ
最小化損失函數來確定,其中i
係自表現單一MHC對偶基因之細胞及/或表現多個MHC對偶基因之細胞產生之訓練數據170之子集S
中的每一實例。 方程式(17)係呈遞模型中之呈遞似然度建模為各自對應於肽 pk
將由個別MHC對偶基因h
呈遞之似然度的內含每一對偶基因呈遞似然度u’k h
之函數。內含每一對偶基因似然度與部分VIII.B之每一對偶基因呈遞似然度之不同之處在於,內含每一對偶基因似然度之參數可自多對偶基因環境學習,其中除單一對偶基因環境外,未知經呈遞肽與相應MHC對偶基因之間之直接相關。因此,在多對偶基因環境中,呈遞模型不僅可估計肽 pk
是否將由MHC對偶基因集H
整體呈遞,且亦可提供指示哪個MHC對偶基因h
最可能呈遞肽 pk
之個別似然度u’k h ∈ H
。此之優點在於,呈遞模型可無需訓練表現單一MHC對偶基因之細胞之數據而產生內含似然度。 在本說明書其餘部分通篇中所提及之一具體執行方案中,r
(∙)係具有範圍[0, 1]之函數。舉例而言,r
(∙)可為修剪函數:, 其中選擇z
與1之間之最小值作為呈遞似然度uk
。在另一執行方案中,當域z
之值等於或大於0時,r
(∙)係藉由下式給出之雙曲正切函數:。VIII.C.5. 實例 3.2 :函數相加模型
在一具體執行方案中,s
(∙)係集成函數,且呈遞似然度係藉由將內含每一對偶基因呈遞似然度相加來給出:在一執行方案中,藉由下式產生針對MHC對偶基因h
之內含每一對偶基因呈遞似然度:使得呈遞似然度係藉由下式來估計:根據方程式(19),肽序列 pk
將由一或多個MHC對偶基因H
呈遞之呈遞似然度可藉由以下方式來產生:將函數gh
(∙)應用於針對MHC對偶基因H
中每一者之肽序列 pk
之經編碼形式以產生對偶基因相互作用變量之相應依賴性評分。首先藉由函數f
(∙)轉換每一依賴性評分以產生內含每一對偶基因呈遞似然度u’k h
。將每一對偶基因似然度u’k h
組合,且可將修剪函數應用於經組合似然度以將各值修剪至範圍[0, 1]內,以產生肽序列 pk
將由MHC對偶基因集H
呈遞之呈遞似然度。依賴性函數 gh
可呈上文在部分VIII.B.1中所引入之任一依賴性函數 gh
形式。 作為實例,肽 pk
將由MHC對偶基因h=2 、 h=3
呈遞之似然度(其中m=4
個不同的經辨識MHC對偶基因)可利用仿射轉換函數gh
(∙)藉由下式來產生:, 其中 x2 k 、 x3 k
係針對MHC對偶基因h=2 、 h=3
之經辨識對偶基因相互作用變量,且 θ2 、 θ3
係對MHC對偶基因h=2 、 h=3
確定之參數集。 作為另一實例,肽 pk
將由MHC對偶基因h=2 、 h=3
呈遞之似然度(其中m=4
個不同的經辨識MHC對偶基因)可利用網路轉換函數gh
(∙)、gw
(∙)藉由下式來產生:, 其中NN2
(∙) 、 NN3
(∙)係針對MHC對偶基因h=2 、 h=3
之經辨識網路模型,且 θ2 、 θ3
係對MHC對偶基因h=2 、 h=3
確定之參數集。 圖11圖解說明利用實例性網路模型NN2
(∙)及NN3
(∙)產生與MHC對偶基因h=
2、h=
3相關之肽 pk
之呈遞似然度。如圖9中所示,網路模型NN2
(∙)接收針對MHC對偶基因h=2
之對偶基因相互作用變量 x2 k
並產生輸出NN2
( x2 k
),且網路模型NN3
(∙)接收針對MHC對偶基因h=3
之對偶基因相互作用變量 x3 k
並產生輸出NN3
( x3 k
)。每一輸出係藉由函數f
(∙)映射且組合以產生所估計之呈遞似然度uk
。 在另一執行方案中,當對質譜離子流之對數進行預測時,r
(∙)係對數函數且f
(∙)係指數函數。VIII.C.6. 實例 3.3 :具有對偶基因非相互作用變量之函數相加模型
在一執行方案中,藉由下式產生針對MHC對偶基因h
之內含每一對偶基因呈遞似然度:使得呈遞似然度係藉由下式來產生:以納入對偶基因非相互作用變量對肽呈遞之影響。 根據方程式(21),肽序列 pk
將由一或多個MHC對偶基因H
呈遞之呈遞似然度可藉由以下方式來產生:將函數gh
(∙)應用於針對MHC對偶基因H
中每一者之肽序列 pk
之經編碼形式以產生針對每一MHC對偶基因h
之對偶基因相互作用變量之相應依賴性評分。亦將針對對偶基因非相互作用變量之函數gw
(∙)應用於對偶基因非相互作用變量之經編碼形式以產生對偶基因非相互作用變量之依賴性評分。將對偶基因非相互作用變量之評分與對偶基因相互作用變量之每一依賴性評分組合。藉由函數f
(∙)轉換每一經組合評分以產生內含每一對偶基因呈遞似然度。將內含似然度組合,且可將修剪函數應用於經組合輸出以將各值修剪至範圍[0,1]內,以產生肽序列 pk
將由MHC對偶基因H
呈遞之呈遞似然度。依賴性函數 gw
可呈上文在部分VIII.B.3中所引入之任一依賴性函數 gw
形式。 作為實例,肽 pk
將由MHC對偶基因h=2 、 h=3
呈遞之似然度(其中m=4
個不同的經辨識MHC對偶基因)可利用仿射轉換函數gh
(∙)、gw
(∙)藉由下式來產生:, 其中 wk
係針對肽 pk
之經辨識對偶基因非相互作用變量,且 θw
係對對偶基因非相互作用變量確定之參數集。 作為另一實例,肽 pk
將由MHC對偶基因h=2 、 h=3
呈遞之似然度(其中m=4
個不同的經辨識MHC對偶基因)可利用網路轉換函數gh
(∙)、gw
(∙)藉由下式來產生:其中 wk
係針對肽 pk
之經辨識對偶基因相互作用變量,且 θw
係對對偶基因非相互作用變量確定之參數集。 圖12圖解說明利用實例性網路模型NN2
(∙)、NN3
(∙)及NNw
(∙)產生與MHC對偶基因h=2 、 h=
3相關之肽 pk
之呈遞似然度。如圖12中所示,網路模型NN2
(∙)接收針對MHC對偶基因h=2
之對偶基因相互作用變量 x2 k
並產生輸出NN2
( x2 k
)。網路模型NNw
(∙)接收針對肽 pk
之對偶基因非相互作用變量 wk
並產生輸出NNw
( wk
)。將輸出組合且藉由函數f
(∙)映射。網路模型NN3
(∙)接收針對MHC對偶基因h=3
之對偶基因相互作用變量 x3 k
並產生輸出NN3
( x3 k
),亦將其與相同網路模型NNw
(∙)之輸出NNw
( wk
)組合且藉由函數f
(∙)映射。將兩個輸出組合以產生所估計之呈遞似然度uk
。 在另一執行方案中,藉由下式產生針對MHC對偶基因h
之內含每一對偶基因呈遞似然度:使得呈遞似然度係藉由下式來產生: VIII.C.7. 實例 4 :二階模型
在一執行方案中,s
(∙)係二階函數,且所估計之肽 pk
之呈遞似然度uk
係藉由下式給出:其中元素u’k h
係針對MHC對偶基因h
之內含每一對偶基因呈遞似然度。針對內含每一對偶基因似然度之參數集 θ
之值可藉由針對 θ
最小化損失函數來確定,其中i
係自表現單一MHC對偶基因之細胞及/或表現多個MHC對偶基因之細胞產生之訓練數據170之子集S
中的每一實例。內含每一對偶基因呈遞似然度可呈上文所述之方程式(18)、(20)及(22)中所示之任一形式。 在一態樣中,方程式(23)之模型可暗示存在肽 pk
將由兩個MHC對偶基因同時呈遞之概率,其中兩個HLA對偶基因之呈遞係統計學上獨立的。 根據方程式(23),肽序列 pk
將由一或多個MHC對偶基因H
呈遞之呈遞似然度可藉由以下方式來產生:組合內含每一對偶基因呈遞似然度並自總和減去每一對MHC對偶基因將同時呈遞肽 pk
之似然度以產生肽序列 pk
將由MHC對偶基因H
呈遞之呈遞似然度。 作為實例,肽 pk
將由HLA對偶基因h=2 、 h=3
呈遞之似然度(其中m=4
個不同的經辨識HLA對偶基因)可利用仿射轉換函數gh
(∙)藉由下式來產生:, 其中 x2 k 、 x3 k
係針對HLA對偶基因h=2 、 h=3
之經辨識對偶基因相互作用變量,且 θ2 、 θ3
係對HLA對偶基因h=2 、 h=3
確定之參數集。 作為另一實例,肽 pk
將由HLA對偶基因h=2 、 h=3
呈遞之似然度(其中m=4
個不同的經辨識HLA對偶基因)可利用網路轉換函數gh
(∙)、gw
(∙)藉由下式來產生:, 其中NN2
(∙) 、 NN3
(∙)係針對HLA對偶基因h=2 、 h=3
之經辨識網路模型,且 θ2 、 θ3
係對HLA對偶基因h=2 、 h=3
確定之參數集。IX. 實例 5 :預測模組
預測模組320接收序列數據且利用呈遞模型在序列數據中選擇候選新抗原。特定而言,序列數據可為自患者之腫瘤組織細胞提取之DNA序列、RNA序列及/或蛋白質序列。預測模組320將序列數據處理成複數個具有8-15個胺基酸之肽序列 pk
。舉例而言,預測模組320可將給定序列「IEFROEIFJEF」處理成三個具有9個胺基酸之肽序列「IEFROEIFJ」、「EFROEIFJE」及「FROEIFJEF」。在一個實施例中,預測模組320可藉由以下方式來辨識為突變肽序列之候選新抗原:比較自患者之正常組織細胞提取之序列數據與自患者之腫瘤組織細胞提取之序列數據以辨識出含有一或多個突變之部分。 呈遞模組320將一或多個呈遞模型應用於經處理之肽序列以估計該等肽序列之呈遞似然度。特定而言,預測模組320可藉由將呈遞模型應用於候選新抗原來選擇一或多個可能呈遞於腫瘤HLA分子上之候選新抗原肽序列。在一執行方案中,呈遞模組320選擇具有大於預定臨限值之經估計呈遞似然度之候選新抗原序列。在另一執行方案中,呈遞模型選擇N
個具有最高經估計呈遞似然度之候選新抗原序列(其中N
通常為可在疫苗中遞送之最大表位數)。可將包括針對給定患者選擇之候選新抗原之疫苗注射至患者中來誘導免疫反應。X. 實例 6 :顯示實例性呈遞模型性能之實驗結果
針對測試數據T
測試上述各個呈遞模型之有效性,測試數據T
係訓練數據170之未用於訓練呈遞模型之亞組或來自訓練數據170之具有與訓練數據170相似之變量及數據結構的單獨數據集。 呈遞模型性能之相關度量指示係:其指示經正確預測以呈遞於相關HLA對偶基因上之肽實例數對經預測以呈遞於HLA對偶基因上之肽實例數的比率。在一執行方案中,若相應似然度估計ui
大於或等於給定臨限值t
,則測試數據T
中之肽 pi
經預測以呈遞於一或多個相關HLA對偶基因上。呈遞模型性能之另一相關度量指示係:其指示經正確預測以呈遞於相關HLA對偶基因上之肽實例數對已知呈遞於HLA對偶基因上之肽實例數的比率。呈遞模型性能之另一相關度量指示係接收者操作特徵(ROC)之曲線下面積(AUC)。ROC繪製召回對偽陽性率(FPR),其係藉由下式給出:。X.A. 針對質譜數據之呈遞模型性能與最新技術模型之比較
圖13A比較如本文所呈現實例性呈遞模型與用於預測針對多對偶基因質譜數據之肽呈遞之最新技術模型的性能結果。結果顯示,實例性呈遞模型在預測肽呈遞方面之性能顯著優於基於親和力及穩定性預測之最新技術模型。 特定而言,利用仿射依賴性函數gh
(∙)及expit函數f
(∙),在圖13A中顯示為「MS」之實例性呈遞模型係方程式(12)中所示每一對偶基因呈遞模型之最大值。實例性呈遞模型係基於來自IEDB數據集(數據集「D1」)之單一對偶基因HLA-A*02:01質譜數據(數據可參見http://www.iedb.org/doc/mhc_ligand_full.zip)的亞組及來自IEDB數據集(數據集「D2」)之單一對偶基因HLA-B*07:02質譜(數據可參見http://www.iedb.org/doc/mhc_ligand_full.zip)的亞組來訓練。自訓練數據消除來自含有測試集中之經呈遞肽之源蛋白之所有肽,使得實例性呈遞模型可不僅僅記憶經呈遞抗原之序列。 在圖13A中顯示為「親和力」之模型係類似於基於親和力預測NETMHCpan預測肽呈遞之當前最新技術模型的模型。NETMHCpan之執行方案詳細提供於http://www.cbs.dtu.dk/services/NetMHCpan/上。在圖13A中顯示為「穩定性」之模型係類似於基於穩定性預測NETMHCstab預測肽呈遞之當前最新技術模型的模型。NETMHCstab之執行方案詳細提供於http://www.cbs.dtu.dk/services/NetMHCstab-1.0/上。測試數據係來自Bassani-Sternberg數據集(數據集「D3」)之多對偶基因JY細胞系HLA-A*02:01及HLA-B*07:02質譜數據(數據可參見www.ebi.ac.uk/pride/ archive/projects/PXD000394 )之亞組。誤差槓(如以實線指示)顯示95%信賴區間。 如圖13A之結果中所示,相對於基於MHC結合親和力預測或MHC結合穩定性預測來預測肽呈遞之最新技術模型,對質譜數據進行訓練之實例性呈遞模型在10%召回率下具有顯著較高之PPV值。特定而言,實例性呈遞模型具有比基於親和力預測之模型高約14%之PPV,且具有比基於穩定性預測之模型高約12%之PPV。 該等結果展示,即使實例性呈遞模型未基於含有經呈遞肽之蛋白質序列進行訓練,實例性呈遞模型仍具有顯著優於基於MHC結合親和力或MHC結合穩定性預測來預測肽呈遞之最新技術模型的性能。X.B. 針對 T 細胞表位數據之呈遞模型性能與最新技術模型之比較
圖13B比較如本文所呈現之另一實例性呈遞模型與用於預測針對T細胞表位數據之肽呈遞之最新技術模型的性能結果。T細胞表位數據含有由細胞表面上之MHC對偶基因呈遞且由T細胞識別之肽序列。結果顯示,即使實例性呈遞模型係基於質譜數據來訓練,實例性呈遞模型在預測T細胞表位方面之性能仍顯著優於基於親和力及穩定性預測之最新技術模型。換言之,圖13B之結果指示,不僅實例性呈遞模型在預測針對質譜測試數據之肽呈遞方面之性能優於最新技術模型,且實例性呈遞模型在預測實際上由T細胞識別之表位方面之性能亦顯著優於最新技術模型。此指示如本文所呈現之多種呈遞模型可提供可能誘導免疫系統中之免疫原性反應之抗原的經改良辨識。 特定而言,利用仿射轉換函數gh
(∙)及expit函數f
(∙),在圖13B中顯示為「MS」之實例性呈遞模型係方程式(2)中所示之基於數據集D1之亞組訓練之每一對偶基因呈遞模型。自訓練數據消除來自含有測試集中之經呈遞肽之源蛋白之所有肽,使得呈遞模型可不僅僅記憶經呈遞抗原之序列。 將每一模型應用於測試數據,其為HLA-A*02:01 T細胞表位數據(數據集「D4」)上之質譜數據(數據可參見www.iedb.org/doc/tcell full v3.zip)之亞組。在圖13B中顯示為「親和力」之模型係類似於基於親和力預測NETMHCpan預測肽呈遞之當前最新技術模型之模型,且在圖13B中顯示為「穩定性」之模型係類似於基於穩定性預測NETMHCstab預測肽呈遞之當前最新技術模型之模型。誤差槓(如以實線指示)顯示95%信賴區間。 如圖13A之結果中所示,即使呈遞模型未基於含有經呈遞肽之蛋白質序列進行訓練,對質譜數據進行訓練之每一對偶基因呈遞模型在10%召回率下仍具有顯著高於基於MHC結合親和力或MHC結合穩定性預測預測肽呈遞之最新技術模型的PPV值。特定而言,每一對偶基因呈遞模型具有比基於親和力預測之模型高約9%之PPV,且具有比基於穩定性預測之模型高約8%之PPV。 該等結果展示,對質譜數據進行訓練之實例性呈遞模型在預測由T細胞識別之表位方面之性能顯著優於最新技術模型。X.C. 針對質譜數據之不同呈遞模型性能之比較
圖13C比較實例性相加函數模型(方程式(13))、實例性函數相加模型(方程式(19))及實例性二階模型(方程式(23))在預測針對多對偶基因質譜數據之肽呈遞方面的性能結果。結果顯示函數相加模型及二階模型之性能優於相加函數模型。此乃因相加函數模型暗示當實際上肽之呈遞係有效地獨立時,多對偶基因環境中之對偶基因可彼此干擾肽呈遞。 特定而言,在圖13C中標記為「相加S型(sigmoid-of-sums)」之實例性呈遞模型係利用網路依賴性函數gh
(∙)、恒等函數f
(∙)及expit函數r
(∙)之相加函數模型。標記為「S型相加(sum-of-sigmoids)」之實例性模型係方程式(19)中利用網路依賴性函數gh
(∙)、expit函數f
(∙)及恒等函數r
(∙)之函數相加模型。標記為「雙曲正切」之實例性模型係方程式(19)中利用網路依賴性函數gh
(∙)、expit函數f
(∙)及雙曲正切函數r
(∙)之函數相加模型。標記為「二階」之實例性模型係方程式(23)中利用方程式(18)中所示利用網路依賴性函數gh
(∙)及expit函數f
(∙)之內含每一對偶基因呈遞似然度形式之二階模型。每一模型係基於數據集D1、D2及D3之亞組來訓練。將實例性呈遞模型應用於測試數據,其為數據集D3之不與訓練數據重疊之隨機亞組。 如圖13C中所示,第一欄係指將每一呈遞模型應用於測試集時ROC之AUC,第二欄係指負對數似然度損失之值,且第三欄係指10%召回率下之PPV。如圖13C中所示,在10%召回下,呈遞模型「S型相加」、「雙曲正切」及「二階」之性能大致等於約15%-16% PPV,而模型「相加S型」之性能稍低於約11%。 如先前部分VIII.C.4.中所論述,結果顯示,呈遞模型「S型相加」、「雙曲正切」及「二階」具有與「相加S型」模型相比較高之PPV值,此乃因該等模型正確地解釋肽係如何獨立地經多對偶基因環境中之每一MHC對偶基因呈遞。X.D. 對單一對偶基因質譜數據進行訓練或不訓練之呈遞模型性能之比較
圖13D比較使用或不使用單一對偶基因質譜數據進行訓練之兩種實例性呈遞模型在預測多對偶基因質譜數據之肽呈遞方面的性能結果。結果指示,不使用單一對偶基因數據進行訓練之實例性呈遞模型達成與使用單一對偶基因數據進行訓練之實例性呈遞模型相當之性能。 「使用A2/B7單一對偶基因數據」之實例性模型係方程式(19)中利用網路依賴性函數gh
(∙)、expit函數f
(∙)及恒等函數r
(∙)之「S型相加」呈遞模型。該模型係基於數據集D3之亞組及來自IEDB數據庫之多個MHC對偶基因之單一對偶基因質譜數據(數據可參見:http://www.iedb.org/doc/mhc_ligand_full.zip)進行訓練。「不使用A2/B7單一對偶基因數據」之實例性模型係相同模型,但基於不含對偶基因HLA-A*02:01及HLA-B*07:02之單一對偶基因質譜數據、但含有其他對偶基因之單一對偶基因質譜數據的多對偶基因D3數據集之亞組進行訓練。在多對偶基因訓練數據內,細胞系HCC1937表現HLA-B*07:02但不表現HLA-A*02:01,且細胞系HCT116表現HLA-A*02:01但不表現HLA-B*07:02。將實例性呈遞模型應用於測試數據,其係數據集D3之隨機亞組且不與訓練數據重疊。 欄「關聯性」係指在測試數據中指示肽是否呈遞於相應對偶基因上之實際標記與預測標記之間的關聯性。如圖13D中所示,基於MHC對偶基因HLA-A*02:01之內含每一對偶基因呈遞似然度的預測之性能顯著優於基於MHC對偶基因HLA-A*02:01而非MHC對偶基因HLA-B*07:02之單一對偶基因測試數據的預測。對MHC對偶基因HLA-B*07:02顯示類似結果。 該等結果指示,即使在訓練數據中未知肽與每一個別MHC對偶基因之間之直接相關,呈遞模型之內含每一對偶基因呈遞似然度仍可正確地預測並區分結合至個別MHC對偶基因之基序。X.E. 不對單一對偶基因質譜數據進行訓練之每一對偶基因預測性能之比較
圖13E顯示圖13D中所示之「不使用A2/B7單一對偶基因數據」及「使用A2/B7單一對偶基因數據」之實例性模型對於圖13D中所示之分析中提供之對偶基因HLA-A*02:01及HLA-B*07:02之單一對偶基因質譜數據之性能。結果指示,即使實例性呈遞模型不使用該兩個對偶基因之單一對偶基因質譜數據進行訓練,該模型仍能夠學習每一MHC對偶基因之結合基序。 如圖13E中所示,「A2模型預測B7」指示當基於MHC對偶基因HLA-A*02:01之內含每一對偶基因呈遞似然度估計針對單一對偶基因HLA-B*07:02數據預測肽呈遞時模型之性能。類似地,「A2模型預測A2」指示當基於MHC對偶基因HLA-A*02:01之內含每一對偶基因呈遞似然度估計針對單一對偶基因HLA-A*02:01預測肽呈遞時模型之性能。「B7模型預測B7」指示當基於MHC對偶基因HLA-B*07:02之內含每一對偶基因呈遞似然度估計針對單一對偶基因HLA-B*07:02數據預測肽呈遞時模型之性能。「B7模型預測A2」指示當基於MHC對偶基因HLA-B*07:02之內含每一對偶基因呈遞似然度估計針對單一對偶基因HLA-A*02:01預測肽呈遞時模型之性能。 如圖13E中所示,HLA對偶基因之內含每一對偶基因似然度對預期對偶基因之預測能力顯著較高,且對另一HLA對偶基因之預測能力顯著較低。與圖13D中所示之結果類似,實例性呈遞模型正確地學習區別個別對偶基因HLA-A*02:01及HLA-B*07:02之肽呈遞,即使在多對偶基因訓練數據中不存在肽呈遞與該等對偶基因之間之直接相關。X.F. 在每一對偶基因預測中頻繁出現之錨定殘基匹配已知典型錨定基序
圖13F顯示由圖13D中所示之「不使用A2/B7單一對偶基因數據」之實例性模型預測之九聚物中之位置2及9的常見錨定殘基。該等肽經預測以在所估計似然度大於5%時被呈遞。結果顯示,經辨識以呈遞於MHC對偶基因HLA-A*02:01及HLA-B*07:02上之肽中之大多數常見錨定殘基匹配先前已知之該等MHC對偶基因之錨定基序。此指示實例性呈遞模型基於肽序列之胺基酸之特定位置正確地學習肽結合,如所預期。 如圖13F中所示,已知位置2之胺基酸L/M及位置9之胺基酸V/L係HLA-A*02:01之典型錨定殘基基序(如https://link.springer.com/article/10.1186/1745-7580-4-2之表4中所示),且已知位置2之胺基酸P及位置9之胺基酸L/V係HLA-B*07:02之典型錨定殘基基序。該模型所辨識之肽之位置2及9之最常見錨定殘基基序匹配兩個HLA對偶基因之已知典型錨定殘基基序。X.G. 具及不具對偶基因非相互作用變量之呈遞模型性能之比較
圖13G比較納入C末端及N末端側接序列作為對偶基因相互作用變量之實例性呈遞模型與納入C末端及N末端側接序列作為對偶基因非相互作用變量之實例性呈遞模型之間的性能結果。結果顯示納入C末端及N末端側接序列作為對偶基因非相互作用變量顯著改良模型性能。更特定而言,頗具價值的是,辨識為不同MHC對偶基因共用之適於肽呈遞之特徵,且對其建模使得該等對偶基因非相互作用變量之統計強度在不同MHC對偶基因之間共享以改良呈遞模型性能。 實例性「對偶基因相互作用」模型係利用網路依賴性函數gh
(∙)及expit函數f
(∙)納入C末端及N末端側接序列作為對偶基因相互作用變量之方程式(22)中之內含每一對偶基因呈遞似然度形式之函數相加模型。實例性「對偶基因-非相互作用」模型係方程式(21)中所示之利用網路依賴性函數gh
(∙)及expit函數f
(∙)納入C末端及N末端側接序列作為對偶基因非相互作用變量之函數相加模型。經由單獨網路依賴性函數gw
(∙)對對偶基因非相互作用變量建模。兩種模型皆係針對數據集D3之亞組及來自IEDB數據庫之多個MHC對偶基因之單一對偶基因質譜數據(數據可參見:http://www.iedb.org/doc/mhc_ligand_full.zip)進行訓練。將每一呈遞模型應用於測試數據集,其係數據集D3之不與訓練數據重疊之隨機亞組。 如圖13G中所示,將C末端及N末端側接序列納入實例性呈遞模型中作為對偶基因非相互作用變量相對於將其建模為對偶基因相互作用變量達成約3%之PPV值改良。一般而言,此乃因「對偶基因非相互作用」實例性呈遞模型能夠藉由利用單獨網路依賴性函數及計算能力之極小增加對效應建模來共享不同MHC對偶基因之對偶基因非相互作用變量之統計強度。X.H. 經呈遞肽與 mRNA 量化之間之依賴性
圖13H圖解說明基於腫瘤細胞之質譜數據之mRNA量化的基因之經呈遞肽之分數之間的依賴性。結果顯示在mRNA表現與肽呈遞之間存在強依賴性。 特定而言,圖13G中之水平軸指示以每百萬轉錄本(TPM)四分位數表示之mRNA表現。圖13G中之垂直軸指示以相應mRNA表現四分位數表示之來自基因之經呈遞表位之分數。每一實線係關於腫瘤樣品之與相應質譜數據及mRNA表現量測相關之兩個量測的曲線。如圖13G中所示,在mRNA表現與相應基因中之肽分數之間存在強正相關。特定而言,RNA表現之最高四分位數之基因之肽被呈遞之可能性比最低四分位數大20倍。此外,自經由RNA未檢測到之基因呈遞基本上0個肽。 結果指示,呈遞模型之性能可藉由納入mRNA量化量測來極大地改良,此乃因該等量測強烈地預測肽呈遞。X.I. 納入 RNA 量化數據之呈遞模型性能之比較
圖13I顯示兩種實例性呈遞模型之性能,其中之一者係基於質譜腫瘤細胞數據進行訓練,其中之另一者納入mRNA量化數據及質譜腫瘤細胞數據。如根據圖13H所預期,結果指示藉由將mRNA量化量測納入實例性呈遞模型中可顯著改良性能,此乃因mRNA表現係肽呈遞之強指示劑。 「MHCflurry + RNA過濾器」係一種類似於基於親和力預測預測肽呈遞之當前最新技術模型之模型。其係利用MHCflurry以及自蛋白質移除mRNA量化量測小於3.2 FPKM之所有肽之標準基因表現過濾器來實施。MHCflurry之執行詳細提供於https://github.com/hammerlab/mhcflurry/及http://biorxiv.org/content/early/2016/05/22/054775。「實例性模型,無RNA」模型係方程式(21)中所示利用網路依賴性函數gh
(∙)、網路依賴性函數gw
(∙)及expit函數f
(∙)之「S型相加」實例性呈遞模型。「實例性模型,無RNA」模型經由網路依賴性函數gw
(∙)納入C端側接序列作為對偶基因非相互作用變量。 「實例性模型,具RNA」模型係方程式(19)中所示利用網路依賴性函數gh
(∙)、方程式(10)中經由對數函數納入mRNA量化數據之網路依賴性函數gw
(∙)及expit函數f
(∙)的「S型相加」呈遞模型。「實例性模型,具RNA」模型經由網路依賴性函數gw
(∙)納入C端側接序列作為對偶基因非相互作用變量且經由對數函數納入mRNA量化量測。 每一模型係針對來自IEDB數據集之單一對偶基因質譜數據、來自Bassani-Sternberg數據集之多對偶基因質譜數據之7種細胞系及20個質譜腫瘤樣品的組合進行訓練。將每一模型應用於包括來自7個腫瘤樣品之5,000個保留蛋白質(held-out proteins)之測試集,該等蛋白質構成總共52,156,840個肽中之9,830個呈遞肽。 如圖13I之前兩個條形圖中所示,「實例性模型,無RNA」模型在20%召回下具有21%之PPV值,而最新技術模型之PPV值為約3%。此指示甚至在不納入mRNA量化量測下PPV值之18%之初始性能改良。如圖13I之第三個條形圖中所示,將mRNA量化數據納入呈遞模型中之「實例性模型,具RNA」模型顯示約30%之PPV值,其性能與無mRNA量化量測之實例性呈遞模型相比幾乎增加10%。 因此,結果指示,如圖13H中之發現所預期,mRNA表現實際上係肽預測之強預測子,其允許顯著改良呈遞模型之性能且極少增加計算複雜性。X.J. 對 MHC 對偶基因 HLA-C*16:04 測定之參數之實例
圖13J比較由參考圖13I所述之「實例性模型,具RNA」呈遞模型產生的結果與由在預測肽呈遞時未將肽長度考慮在內之最新技術模型預測的結果之間之對不同肽長度之肽呈遞之機率。結果指示,圖13I之「實例性模型,具RNA」實例性呈遞模型捕獲不同長度之肽之似然度變化。 水平軸表示具有長度8、9、10及11之肽之樣品。垂直軸表示針對肽長度條件化之肽呈遞機率。曲線「實際測試數據機率」顯示根據測試數據集中樣品之肽長度之經呈遞肽之比例。呈遞似然度隨肽長度而變化。舉例而言,如圖13J中所示,具有典型HLA-A2 L/V錨定基序之10聚體肽被呈遞之可能性比具有相同錨定殘基之9聚體小約3倍。曲線「忽略長度之模型」指示欲將忽略肽長度之最新技術模型應用於相同測試數據集用於呈遞預測時之經預測量測。該等模型可為4.0版前之NetMHC版、3.0版前之NetMHCpan版及未將肽呈遞隨肽長度之變化考慮在內之MHCflurry。如圖13J中所示,經呈遞肽之比例在不同肽長度值之間將恆定,此指示該等模型將無法捕獲肽呈遞隨長度之變化。曲線「Gritstone,具RNA」指示自「Gritstone,具RNA」呈遞模型產生之量測值。如圖13J中所示,由「Gritstone,具RNA」模型產生之量測值緊密地遵循「實際測試數據機率」中所示之彼等且正確地解釋針對長度8、9、10及11之不同肽呈遞程度。 因此,結果顯示,如本文所呈現之實例性呈遞模型不僅針對9聚體肽、且亦針對介於8-15之間之其他長度之肽產生經改良之預測,此佔據I類HLA對偶基因中經呈遞肽之高達40%。X.K. 對 MHC 對偶基因 HLA-C*16:04 測定之參數之實例
下文顯示對由h
表示之MHC對偶基因HLA-C*16:04之每一對偶基因呈遞模型(方程式(2))之變化測定的參數集:, 其中relu(∙)係修正線性單元(RELU)函數,且 Wh 1 、 bh 1 、 Wh 2
及bh 2
係對該模型測定之參數集 θ
。對偶基因相互作用變量 xh k
係由肽序列組成。 Wh 1
之維度係(231 × 256), bh 1
之維度係(1 × 256), Wh 2
之維度係(256 × 1),且 bh 2
係純量。出於展示之目的, bh 1
、bh 2
、 Wh 1
及 Wh 2
之值列示於下文中。 bh 1
: [-1.25887644 -0.84448904 -1.71391594 -1.38860381 -1.15529644 -2.42168117 -1.98687959 -0.8488462 -1.6607399 -1.12956274 -2.08983159 -0.53710765 -0.49313864 -1.15045631 -0.48757577 -0.55577797 -0.31031775 -0.70026076 -1.04614675 -1.3850919 -1.82895124 -1.15633833 -1.2794342 -2.40924239 -1.38725305 -1.98276925 -1.45160246 -0.81624526 -0.59441668 -1.86188185 -0.83900708 -1.33677316 -1.68388879 -1.1717515 -1.27319682 -1.05872869 -1.34773123 -1.61631954 -0.82552254 -1.64032412 -1.26584375 -0.56390315 -1.00684011 -1.16896808 -2.27648878 -0.66619354 -2.08268309 -0.90704113 -1.17440355 -1.06266129 -1.14868402 -0.98686731 -1.1801722 -1.41404176 -0.92722374 -0.61310995 -1.69453728 -1.26077592 -1.80019915 -0.55121636 -1.42537642 -2.1196804 -1.32291269 -1.30997157 -0.8173914 -1.23448598 -0.92230183 -1.04590237 -0.68719882 -0.99965096 -1.85294855 -0.67477435 -1.31483507 -1.21778536 -1.18890083 -0.80372357 -1.90210617 -1.85402811 -1.05570829 -1.345541 -0.68872309 -1.91153145 -1.15126705 -0.9407478 -1.01246905 -1.36009204 -1.15897787 -1.38631177 -0.87737125 -0.81053489 -0.5077101 -0.36021063 -1.06372654 -1.03310466 -1.15494275 -2.19268966 -0.80285913 -0.79190463 -0.93620723 -1.30614185 -1.85568225 -2.38452196 -1.67495275 -0.70025575 -0.98393178 -1.83200908 -1.07078218 -0.98362595 -0.71674275 -2.04092884 -0.81029147 -0.92036235 -1.75404763 -1.45618188 -0.87118417 -0.54004192 -1.65154266 -1.28891158 -1.98474801 -1.20875657 -1.51076365 -1.44827867 -1.60024345 -1.5518645 -1.22961164 -1.33044851 -1.78681803 -1.60184741 -1.70247972 -1.48592603 -1.19963896 -2.06061363 -1.59096014 -1.18787074 -1.19529891 -0.61437321 -0.92168951 -0.91861475 -1.55775297 -1.57438934 -1.76918828 -2.1351223 -1.28325438 -1.17691207 -0.9070273 -0.92114311 -1.37144518 -1.05090868 -1.00942171 -1.12824321 -0.94788575 -1.27639067 -1.39774501 -1.06832922 -1.03379047 -1.49880815 -1.23712206 -1.15053117 -1.34290957 -1.66009867 -0.92846054 -0.97625399 -0.77744013 -1.93288314 -1.11750412 -0.97511715 -0.74683744 -1.13343358 -1.20803583 -1.436432 -1.50354922 -1.00136673 -2.01420403 -1.2733649 -0.92629886 -1.29439116 -1.64390576 -1.23867738 -0.88478297 -0.85971212 -1.85386622 -1.53856933 -2.06025767 -1.88411045 -1.49906313 -1.32475007 -1.117347 -1.68465662 -0.69363773 -1.5894047 -1.97358358 -2.59916759 -1.35396743 -2.30461049 -0.99292755 -1.27674675 -0.86507457 -0.94777668 -1.35009873 -1.47957981 -0.66513908 -1.06404948 -1.06712294 -1.72618425 -1.63874471 -1.46202075 -0.89948207 -1.20573676 -1.24084079 -1.19317305 -0.93100727 -1.02617919 -0.76241934 -1.87542462 -1.03179228 -1.45539415 -1.36384034 -0.96758604 -0.86005205 -0.80283695 -1.1137774 -1.53601909 -1.13732922 -1.12731791 -1.23490679 -1.33152759 -1.02586186 -1.44582832 -1.92057085 -1.30637109 -2.32667851 -1.57416546 -1.30796921 -0.70605123 -2.00818539 -1.46872818 -0.92903972 -1.57068658 -1.23099935 -1.05193675 -1.35168147 -0.52318192 -0.8894254 -1.69644272 -1.18933356 -1.11279356 -1.06844199 -1.36696768 -1.31789732 -1.63881576 -0.56565195 -0.52174371 -0.93638539 -2.07027268 -1.60358965 -1.22863901] bh 2
: -2.88706302643 Wh 2
: [-1.35359335 -0.578529 -0.13680433 0.17503858 -0.20488028 -0.54827738 -0.2597248 -1.73813021 -1.02167261 0.09387285 -0.63083726 -0.40662372 -0.47041351 -0.32108155 0.11540248 -0.10392507 -0.27698821 0.03336413 -0.72273839 -0.53308272 -0.25452602 -0.68693435 -0.11388378 -1.02962244 -1.22807848 -0.56124699 -0.56379735 -0.18465492 0.14469336 -0.41948733 -1.01185989 -1.1557889 -0.70585167 -0.54171222 -0.14044708 -0.4110463 -0.90434784 -0.61688143 -0.99438584 -1.55196273 -0.94430661 -0.39086425 -0.99821037 0.33283517 -0.69542056 0.14739829 -0.47792649 0.27000278 -0.64110023 -1.90988696 -0.37607646 0.11039938 -0.7492047 -0.17413628 -1.15171742 -0.68284678 -0.06158932 -1.04064727 -0.7101987 -0.86431879 -0.67057228 -0.68295568 0.08244683 -0.86153275 -0.31266105 -0.21919173 -0.79513979 0.17517358 -0.29372135 -1.68132675 -0.6964252 -0.47992685 0.00768639 -0.3944906 -0.99549603 -1.29167581 -0.82665157 -0.66138375 0.14107071 -0.89010292 -0.49536058 -0.90695 -0.84300721 -0.85446638 -0.99457145 -0.84283727 -1.26285946 -0.7482127 -1.32341206 -0.14178833 -0.47957143 0.22300801 0.22044657 -0.07665028 0.19888243 -0.68686688 0.09093325 0.20991775 -0.47505447 -1.29607451 -0.79738855 -0.6163758 -0.25245398 -0.24964713 -0.70785236 -0.14511365 0.23526534 -1.37460887 -0.42035979 -0.76954895 0.01340491 -0.23353948 -1.45486987 -2.10253382 0.31412357 0.05441735 -1.16719246 -0.53678679 -1.21121192 0.36880198 -1.7501055 -1.08759594 -1.03163946 -0.87725466 -1.04990077 -0.23935798 -0.70022678 -0.30579087 -1.51719499 -0.05505106 -0.30621436 -0.37509263 -0.35138479 0.08471824 -0.30281609 -0.40951991 -0.88454992 0.04506355 0.12505099 -0.79208314 -0.98382056 -0.73998731 -0.68265402 -0.30925721 -0.30487028 -0.18522757 -0.51589108 -0.14071934 -0.58638161 -0.37126878 -0.36587363 -1.98553813 -0.52241606 -0.33231446 -1.05311215 -1.1445843 0.1126269 -0.18052928 -0.87758267 -1.06622291 -1.76154435 -0.16173303 -1.38007092 -0.67007738 -0.95604581 -0.71263856 0.04040499 -0.84706324 0.3145974 -0.89040732 -0.75084466 -2.24529719 -0.90706474 0.08718969 -2.26292086 -0.43557408 -0.16575792 -1.28786123 -0.76409894 -1.2387414 -1.00480986 -1.59728515 -1.76675069 -0.45098865 0.37770402 -2.14156651 0.17127 -1.07672346 -0.63889885 -1.85108674 0.09201332 -0.64665085 -1.47701621 -0.27428123 0.11656716 -0.71997839 0.25774828 -0.65556616 -0.12599011 -1.19412673 0.05263189 -0.25015593 0.15155405 -0.71724749 -1.8973484 -0.01961765 -0.85265714 -0.54098094 -1.15418613 -0.55546618 -0.95463139 -1.48755825 -1.03432381 -0.82399344 -0.91085857 0.0421642 -0.55967122 -0.70061207 0.24029407 -0.97962326 -0.75661993 -0.6151405 -1.64357328 -1.16723275 -0.04848668 -0.62112832 -0.91200793 -0.5882951 -0.50034207 0.01658128 -0.58651829 -0.12295453 -0.13033544 0.07790214 -0.678482 -0.62363708 0.08507859 -0.94984204 0.00797078 -1.03968978 0.01618595 -0.11407378 0.2762318 -0.7622599 -1.18186867 -0.71437931 0.25219718 -1.02577722 -0.3844451 -0.210338 -0.34110329 -1.00708425 -0.23432316 -0.29608929 0.1013524 -0.40958044]XI. 實例性電腦
圖14圖解說明用於執行圖1及3中所示之實體之實例性電腦1400。電腦1400包括至少一個耦合至晶片集1404之處理器1402。晶片集1404包括記憶體控制器集線器1420及輸入/輸出(I/O)控制器集線器1422。記憶體1406及圖形配接器1412耦合至記憶體控制器集線器1420,且顯示器1418耦合至圖形配接器1412。存儲裝置1408、輸入裝置1414及網路配接器1416耦合至I/O控制器集線器1422。電腦1400之其他實施例具有不同架構。 存儲裝置1408係非暫時性電腦可讀存儲媒體,例如硬驅動機、唯讀光碟記憶體(CD-ROM)、DVD或固態記憶體裝置。記憶體1406容納處理器1402所用之指令及數據。輸入介面1414係觸控螢幕介面、鼠標、跟蹤球或其他類型之指向裝置、鍵盤1410或其一些組合,且用於將數據輸入電腦1400中。在一些實施例中,電腦1400可經組態以經由使用者之手勢自輸入介面1414接收輸入(例如,命令)。圖形配接器1412在顯示器1418上顯示影像及其他資訊。網路配接器1416將電腦1400耦合至一或多個電腦網路。 電腦1400經配接以執行用於提供本文所述之功能之電腦程式模組。如本文所用術語「模組」係指用於提供所規定功能之電腦程式邏輯。因此,模組可以硬體、韌體及/或軟體來實施。在一個實施例中,程式模組存儲於存儲裝置1408上,裝載至記憶體1406中,且由處理器1402來執行。 圖1之實體所用之電腦1400之類型可端視實施例及實體所需之處理能力而變化。舉例而言,呈遞辨識系統160可在單一電腦1400或經由例如呈伺服器農場中之網路彼此連通多個電腦1400中運行。電腦1400可缺少上文所述之一些組份,例如圖形配接器1412及顯示器1418。 參考文獻 1. Desrichard, A.、Snyder, A.及Chan, T. A. Cancer Neoantigens and Applications for Immunotherapy.Clin. Cancer Res. Off. J. Am. Assoc. Cancer Res.
(2015). doi:10.1158/1078-0432.CCR-14-3175 2. Schumacher, T. N.及Schreiber, R. D. Neoantigens in cancer immunotherapy.Science 348,
69-74 (2015)。 3. Gubin, M. M.、Artyomov, M. N.、Mardis, E. R.及Schreiber, R. D. Tumor neoantigens: building a framework for personalized cancer immunotherapy.J. Clin. Invest. 125,
3413-3421 (2015)。 4. Rizvi, N. A.等人,Cancer immunology. Mutational landscape determines sensitivity to PD-1 blockade in non-small cell lung cancer.Science 348,
124-128 (2015)。 5. Snyder, A.等人,Genetic basis for clinical response to CTLA-4 blockade in melanoma.N. Engl. J. Med. 371,
2189-2199 (2014)。 6. Carreno, B. M.等人,Cancer immunotherapy. A dendritic cell vaccine increases the breadth and diversity of melanoma neoantigen-specific T cells.Science 348,
803-808 (2015)。 7. Tran, E.等人,Cancer immunotherapy based on mutation-specific CD4+ T cells in a patient with epithelial cancer.Science 344,
641-645 (2014)。 8. Hacohen, N.及Wu, C. J.-Y. 美國專利申請案:0110293637 - COMPOSITIONS AND METHODS OF IDENTIFYING TUMOR SPECIFIC NEOANTIGENS. (A1). <http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=/netahtml/PTO/srchnum.html&r=1&f=G&l=50&s1=20110293637.PGNR.> 9. Lundegaard, C.、Hoof, I.、Lund, O.及Nielsen, M. State of the art and challenges in sequence based T-cell epitope prediction.Immunome Res. 6 Suppl 2,
S3 (2010)。 10. Yadav, M.等人,Predicting immunogenic tumour mutations by combining mass spectrometry and exome sequencing.Nature 515,
572-576 (2014)。 11. Bassani-Sternberg, M.、Pletscher-Frankild, S.、Jensen, L. J.及Mann, M. Mass spectrometry of human leukocyte antigen class I peptidomes reveals strong effects of protein abundance and turnover on antigen presentation.Mol. Cell. Proteomics MCP 14,
658-673 (2015)。 12. Van Allen, E. M.等人,Genomic correlates of response to CTLA-4 blockade in metastatic melanoma.Science 350,
207-211 (2015)。 13. Yoshida, K.及Ogawa, S. Splicing factor mutations and cancer.Wiley Interdiscip. Rev. RNA 5,
445-459 (2014)。 14. Cancer Genome Atlas Research Network. Comprehensive molecular profiling of lung adenocarcinoma.Nature 511,
543-550 (2014)。 15. Rajasagi, M.等人,Systematic identification of personal tumor-specific neoantigens in chronic lymphocytic leukemia.Blood 124,
453-462 (2014)。 16. Downing, S. R.等人,美國專利申請案:0120208706 - OPTIMIZATION OF MULTIGENE ANALYSIS OF TUMOR SAMPLES. (A1). <http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=/netahtml/PTO/srchnum.html&r=1&f=G&l=50&s1=20120208706.PGNR.> 17. Target Capture for NextGen Sequencing - IDT. <http://www.idtdna.com/pages/products/nextgen/target-capture> 18. Shukla, S. A.等人,Comprehensive analysis of cancer-associated somatic mutations in class I HLA genes.Nat. Biotechnol. 33,
1152-1158 (2015)。 19. Cieslik, M.等人,The use of exome capture RNA-seq for highly degraded RNA with application to clinical cancer sequencing.Genome Res. 25,
1372-1381 (2015)。 20. Bodini, M.等人,The hidden genomic landscape of acute myeloid leukemia: subclonal structure revealed by undetected mutations.Blood 125,
600-605 (2015)。 21. Saunders, C. T.等人,Strelka: accurate somatic small-variant calling from sequenced tumor-normal sample pairs.Bioinforma. Oxf. Engl. 28,
1811-1817 (2012)。 22. Cibulskis, K.等人,Sensitive detection of somatic point mutations in impure and heterogeneous cancer samples.Nat. Biotechnol. 31,
213-219 (2013)。 23. Wilkerson, M. D.等人,Integrated RNA and DNA sequencing improves mutation detection in low purity tumors.Nucleic Acids Res. 42,
e107 (2014)。 24. Mose, L. E.、Wilkerson, M. D.、Hayes, D. N.、Perou, C. M.及Parker, J. S. ABRA: improved coding indel detection via assembly-based realignment.Bioinforma. Oxf. Engl. 30,
2813-2815 (2014)。 25. Ye, K.、Schulz, M. H.、Long, Q.、Apweiler, R.及Ning, Z. Pindel: a pattern growth approach to detect break points of large deletions and medium sized insertions from paired-end short reads.Bioinforma. Oxf. Engl. 25,
2865-2871 (2009)。 26. Lam, H. Y. K.等人,Nucleotide-resolution analysis of structural variants using BreakSeq and a breakpoint library.Nat. Biotechnol. 28,
47-55 (2010)。 27. Frampton, G. M.等人,Development and validation of a clinical cancer genomic profiling test based on massively parallel DNA sequencing.Nat. Biotechnol. 31,
1023-1031 (2013)。 28. Boegel, S.等人,HLA typing from RNA-Seq sequence reads.Genome Med. 4,
102 (2012)。 29. Liu, C.等人,ATHLATES: accurate typing of human leukocyte antigen through exome sequencing.Nucleic Acids Res. 41,
e142 (2013)。 30. Mayor, N. P.等人,HLA Typing for the Next Generation.PloS One 10,
e0127153 (2015)。 31. Roy, C. K.、Olson, S.、Graveley, B. R.、Zamore, P. D.及Moore, M. J. Assessing long-distance RNA sequence connectivity via RNA-templated DNA-DNA ligation.eLife 4,
(2015)。 32. Song, L.及Florea, L. CLASS: constrained transcript assembly of RNA-seq reads.BMC Bioinformatics 14 Suppl 5,
S14 (2013)。 33. Maretty, L.、Sibbesen, J. A.及Krogh, A. Bayesian transcriptome assembly.Genome Biol. 15,
501 (2014)。 34. Pertea, M.等人,StringTie enables improved reconstruction of a transcriptome from RNA-seq reads.Nat. Biotechnol. 33,
290-295 (2015)。 35. Roberts, A.、Pimentel, H.、Trapnell, C.及Pachter, L. Identification of novel transcripts in annotated genomes using RNA-Seq.Bioinforma. Oxf. Engl.
(2011). doi:10.1093/bioinformatics/btr355 36. Vitting-Seerup, K.、Porse, B. T.、Sandelin, A.及Waage, J. spliceR: an R package for classification of alternative splicing and prediction of coding potential from RNA-seq data.BMC Bioinformatics 15,
81 (2014)。 37. Rivas, M. A.等人,Human genomics. Effect of predicted protein-truncating genetic variants on the human transcriptome.Science 348,
666-669 (2015)。 38. Skelly, D. A.、Johansson, M.、Madeoy, J.、Wakefield, J.及Akey, J. M. A powerful and flexible statistical framework for testing hypotheses of allele-specific gene expression from RNA-seq data.Genome Res. 21,
1728-1737 (2011)。 39. Anders, S.、Pyl, P. T.及Huber, W. HTSeq--a Python framework to work with high-throughput sequencing data.Bioinforma. Oxf. Engl. 31,
166-169 (2015)。 40. Furney, S. J.等人,SF3B1 mutations are associated with alternative splicing in uveal melanoma.Cancer Discov.
(2013). doi:10.1158/2159-8290.CD-13-0330 41. Zhou, Q.等人,A chemical genetics approach for the functional assessment of novel cancer genes.Cancer Res.
(2015). doi:10.1158/0008-5472.CAN-14-2930 42. Maguire, S. L.等人,SF3B1 mutations constitute a novel therapeutic target in breast cancer.J. Pathol. 235,
571-580 (2015)。 43. Carithers, L. J.等人,A Novel Approach to High-Quality Postmortem Tissue Procurement: The GTEx Project.Biopreservation Biobanking 13,
311-319 (2015)。 44. Xu, G.等人,RNA CoMPASS: a dual approach for pathogen and host transcriptome analysis of RNA-seq datasets.PloS One 9,
e89445 (2014)。 45. Andreatta, M.及Nielsen, M. Gapped sequence alignment using artificial neural networks: application to the MHC class I system.Bioinforma. Oxf. Engl.
(2015). doi:10.1093/bioinformatics/btv639 46. Jørgensen, K. W.、Rasmussen, M.、Buus, S.及Nielsen, M. NetMHCstab - predicting stability of peptide-MHC-I complexes; impacts for cytotoxic T lymphocyte epitope discovery.Immunology 141,
18-26 (2014)。 47. Larsen, M. V.等人,An integrative approach to CTL epitope prediction: a combined algorithm integrating MHC class I binding, TAP transport efficiency, and proteasomal cleavage predictions.Eur. J. Immunol. 35,
2295-2303 (2005)。 48. Nielsen, M.、Lundegaard, C.、Lund, O.及Keşmir, C. The role of the proteasome in generating cytotoxic T-cell epitopes: insights obtained from improved predictions of proteasomal cleavage.Immunogenetics 57,
33-41 (2005)。 49. Boisvert, F.-M.等人,A Quantitative Spatial Proteomics Analysis of Proteome Turnover in Human Cells.Mol. Cell. Proteomics 11,
M111.011429-M111.011429 (2012)。 50. Duan, F.等人,Genomic and bioinformatic profiling of mutational neoepitopes reveals new rules to predict anticancer immunogenicity.J. Exp. Med. 211,
2231-2248 (2014)。 51. Janeway’s Immunobiology: 9780815345312: Medicine & Health Science Books @ Amazon.com. <http://www.amazon.com/Janeways-Immunobiology-Kenneth-Murphy/dp/0815345313> 52. Calis, J. J. A.等人,Properties of MHC Class I Presented Peptides That Enhance Immunogenicity.PLoS Comput. Biol. 9,
e1003266 (2013)。 53. Zhang, J.等人,Intratumor heterogeneity in localized lung adenocarcinomas delineated by multiregion sequencing.Science 346,
256-259 (2014) 54. Walter, M. J.等人,Clonal architecture of secondary acute myeloid leukemia.N. Engl. J. Med.
366, 1090-1098 (2012)。 55. Hunt DF、Henderson RA、Shabanowitz J、Sakaguchi K、Michel H、Sevilir N、Cox AL、Appella E、Engelhard VH. Characterization of peptides bound to the class I MHC molecule HLA-A2.1 by mass spectrometry. Science 1992. 255: 1261-1263。 56. Zarling AL、Polefrone JM、Evans AM、Mikesh LM、Shabanowitz J、Lewis ST、Engelhard VH、Hunt DF. Identification of class I MHC-associated phosphopeptides as targets for cancer immunotherapy. Proc Natl Acad Sci U S A. 2006年10月3日;103(40):14889-94。 57. Bassani-Sternberg M、Pletscher-Frankild S、Jensen LJ、Mann M. Mass spectrometry of human leukocyte antigen class I peptidomes reveals strong effects of protein abundance and turnover on antigen presentation.Mol Cell Proteomics. 2015年3月;14(3):658-73. doi: 10.1074/mcp.M114.042812。 58. Abelin JG、Trantham PD、Penny SA、Patterson AM、Ward ST、Hildebrand WH、Cobbold M、Bai DL、Shabanowitz J、Hunt DF.Complementary IMAC enrichment methods for HLA-associated phosphopeptide identification by mass spectrometry.
Nat Protoc. 2015年9月;10(9):1308-18. doi: 10.1038/nprot.2015.086. Epub 2015年8月6日 59. Barnstable CJ、Bodmer WF、Brown G、Galfre G、Milstein C、Williams AF、Ziegler A. Production of monoclonal antibodies to group A erythrocytes, HLA and other human cell surface antigens-new tools for genetic analysis.Cell. 1978年5月;14(1):9-20。 60. Goldman JM、Hibbin J、Kearney L、Orchard K、Th'ng KH. HLA-DR monoclonal antibodies inhibit the proliferation of normal and chronic granulocytic leukaemia myeloid progenitor cells.Br J Haematol. 1982年11月;52(3):411-20。 61. Eng JK、Jahan TA、Hoopmann MR.Comet: an open-source MS/MS sequence database search tool.
Proteomics. 2013年1月;13(1):22-4. doi: 10.1002/pmic.201200439. Epub 2012年12月4日。 62. Eng JK、Hoopmann MR、Jahan TA、Egertson JD、Noble WS、MacCoss MJ.A deeper look into Comet--implementation and features.
J Am Soc Mass Spectrom. 2015年11月;26(11):1865-74. doi: 10.1007/s13361-015-1179-x. Epub 2015年6月27日。 63. Lukas Käll、Jesse Canterbury、Jason Weston、William Stafford Noble及Michael J. MacCoss.Semi-supervised learning for peptide identification from shotgun proteomics datasets
. Nature Methods 4:923 - 925, 2007年11月 64. Lukas Käll、John D. Storey、Michael J. MacCoss及William Stafford Noble.Assigning confidence measures to peptides identified by tandem mass spectrometry
. Journal of Proteome Research, 7(1):29-34, 2008年1月 65. Lukas Käll、John D. Storey及William Stafford Noble.Nonparametric estimation of posterior error probabilities associated with peptides identified by tandem mass spectrometry
. Bioinformatics, 24(16):i42-i48, 2008年8月 66. Bo Li及Colin N. Dewey. RSEM: accurate transcript quantification from RNA-Seq data with or without a referenfe genome. BMC Bioinformatics, 12:323, 2011年8月 67. Hillary Pearson、Tariq Daouda、Diana Paola Granados、Chantal Durette、Eric Bonneil、Mathieu Courcelles、Anja Rodenbrock、Jean-Philippe Laverdure、Caroline Côté、Sylvie Mader、Sébastien Lemieux、Pierre Thibault及Claude Perreault. MHC class I-associated peptides derive from selective regions of the human genome. The Journal of Clinical Investigation, 2016。 68. Juliane Liepe、Fabio Marino、John Sidney、Anita Jeko、Daniel E. Bunting、Alessandro Sette、Peter M. Kloetzel、Michael P. H. Stumpf、Albert J. R. Heck、Michele Mishto. A large fraction of HLA class I ligands are proteasome-generated spliced peptides. Science, 21, 2016年10月。 表Wh 1
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110‧‧‧患者114‧‧‧候選新抗原序列118‧‧‧疫苗160‧‧‧呈遞辨識系統165‧‧‧呈遞資訊存儲區/呈遞資訊170‧‧‧訓練數據存儲區/訓練數據170A‧‧‧訓練數據175‧‧‧呈遞模型存儲區312‧‧‧數據管控模組314‧‧‧編碼模組316‧‧‧訓練模組320‧‧‧預測模組1400‧‧‧電腦1402‧‧‧處理器1404‧‧‧晶片集1406‧‧‧記憶體1408‧‧‧存儲裝置1410‧‧‧鍵盤1412‧‧‧圖形配接器1414‧‧‧輸入裝置/輸入介面/指向裝置1416‧‧‧網路配接器1418‧‧‧顯示器1420‧‧‧記憶體控制器集線器1422‧‧‧輸入/輸出控制器集線器
關於以下描述及附圖將較佳地理解本發明之該等及其他特徵、態樣及優點,其中: 圖(FIG.) 1A顯示新抗原辨識之當前臨床方法。 圖1B顯示<5%之經預測結合肽呈遞於腫瘤細胞上。 圖1C顯示新抗原預測特異性問題之影響。 圖1D顯示結合預測對於新抗原辨識並不足夠。 圖1E顯示MHC-I呈遞隨肽長度變化之機率。 圖1F顯示自Promega動態範圍標準產生之實例性肽譜。 圖1G顯示添加特徵如何增加模型陽性預測值。 圖2A係根據實施例用於辨識患者中之肽呈遞似然度之環境的概述。 圖2B及2C圖解說明根據實施例獲得呈遞資訊之方法。 圖3係圖解說明一實施例之呈遞辨識系統之電腦邏輯組件之高階方塊圖。 圖4圖解說明一實施例之實例性訓練數據集。 圖5圖解說明與MHC對偶基因相關之實例性網路模型。 圖6A及6B圖解說明MHC對偶基因所共享之實例性網路模型。 圖7圖解說明利用實例性網路模型產生與MHC對偶基因相關之肽之呈遞似然度。 圖8圖解說明利用實例性網路模型產生與MHC對偶基因相關之肽之呈遞似然度。 圖9圖解說明利用實例性網路模型產生與MHC對偶基因相關之肽之呈遞似然度。 圖10圖解說明利用實例性網路模型產生與MHC對偶基因相關之肽之呈遞似然度。 圖11圖解說明利用實例性網路模型產生與MHC對偶基因相關之肽之呈遞似然度。 圖12圖解說明利用實例性網路模型產生與MHC對偶基因相關之肽之呈遞似然度。 圖13A至13J圖解說明各個實例性呈遞模型之性能結果。 圖14圖解說明用於執行圖1及3中所示之實體之實例性電腦。
110‧‧‧患者
114‧‧‧候選新抗原序列
118‧‧‧疫苗
160‧‧‧呈遞辨識系統
165‧‧‧呈遞資訊存儲區/呈遞資訊
Claims (82)
- 一種自個體之腫瘤細胞辨識一或多種可能呈遞於腫瘤細胞表面上之新抗原之方法,其包含以下步驟:自該個體之腫瘤細胞獲得外顯子體、轉錄體或全基因體腫瘤核苷酸測序數據中之至少一者,其中使用該腫瘤核苷酸測序數據來獲得代表新抗原集中每一者之肽序列之數據,且其中每一新抗原之肽序列包含至少一個使其不同於相應野生型親代肽序列之變化;將每一新抗原之肽序列輸入一或多種呈遞模型中以產生該等新抗原中之每一者由該個體腫瘤細胞之腫瘤細胞表面上的一或多個MHC對偶基因呈遞之數值似然度集(set of numerical likelihoods),該數值似然度集已至少基於所接收之質譜數據辨識;其中該一或多種呈遞模型係使用訓練數據集訓練,該訓練數據集包含:訓練肽序列,至少一個與該訓練肽序列相關之MHC對偶基因,以及指示一或多種訓練肽序列是否由該至少一個MHC對偶基因所呈遞之標記;及基於該數值似然度集選擇該新抗原集之子集以產生經選擇新抗原集。
- 如請求項1之方法,其中該經選擇新抗原集之數量係20。
- 如請求項1至2中任一項之方法,其中該呈遞模型代表以下之間之依 賴性:該等MHC對偶基因中之特定一者及肽序列特定位置之特定胺基酸之對的存在;與藉由該對之MHC對偶基因中之特定一者,包含該特定位置之特定胺基酸之肽序列呈遞於該腫瘤細胞表面上之似然度(likelihood)。
- 如請求項1至2中任一項之方法,其中輸入該肽序列包含:將該一或多種呈遞模型應用於該相應新抗原之肽序列以產生該一或多個MHC對偶基因中每一者之依賴性評分,其指示該MHC對偶基因是否將至少基於該相應新抗原之肽序列之胺基酸位置來呈遞該相應新抗原。
- 如請求項4之方法,其進一步包含:轉換該等依賴性評分以產生每一MHC對偶基因之相應每一對偶基因(per-allele)似然度,其指示該相應MHC對偶基因將呈遞該相應新抗原之似然度;及組合該等每一對偶基因似然度以產生該數值似然度。
- 如請求項5之方法,其中轉換該等依賴性評分將該相應新抗原之肽序列之呈遞建模為互斥。
- 如請求項4之方法,其進一步包含:轉換該等依賴性評分之組合以產生該數值似然度。
- 如請求項7之方法,其中轉換該等依賴性評分之組合將該相應新抗原之肽序列之呈遞建模為MHC對偶基因間之干擾。
- 如請求項4之方法,其中該數值似然度集進一步藉由至少一個對偶基因非相互作用特徵來辨識,且進一步包含:將該一或多種呈遞模型中之對偶基因非相互作用者應用於該等對偶基因非相互作用特徵以產生該等對偶基因非相互作用特徵之依賴性評分,其指示該相應新抗原之肽序列是否將基於該等對偶基因非相互作用特徵來呈遞。
- 如請求項9之方法,其進一步包含:組合該一或多個MHC對偶基因中之每一MHC對偶基因之依賴性評分與該對偶基因非相互作用特徵之依賴性評分;轉換每一MHC對偶基因之組合依賴性評分以產生該MHC對偶基因之相應每一對偶基因似然度,其指示該相應MHC對偶基因將呈遞該相應新抗原之似然度;及組合該等每一對偶基因似然度以產生該數值似然度。
- 如請求項10之方法,其進一步包含:轉換該等MHC對偶基因中每一者之依賴性評分及該等對偶基因非相互作用特徵之依賴性評分的組合以產生該數值似然度。
- 如請求項1至2中任一項之方法,其中用於該呈遞模型之數值參數集係基於訓練數據集來訓練,該訓練數據集包括至少一個辨識為存在於複數個樣品中之訓練肽序列集及一或多個與每一訓練肽序列相關之MHC對偶基因,其中該等訓練肽序列係經由源自該複數個樣品之MHC對偶基因溶析之分離肽的質譜來辨識。
- 如請求項12之方法,其中該訓練數據集進一步包括該腫瘤細胞之mRNA表現量之數據。
- 如請求項12之方法,其中該等樣品包含經改造以表現單一I類或II類MHC對偶基因之細胞系。
- 如請求項12之方法,其中該等樣品包含經改造以表現複數個I類或II類MHC對偶基因之細胞系。
- 如請求項12之方法,其中該等樣品包含獲自或源自複數個患者之人類細胞系。
- 如請求項12之方法,其中該等樣品包含自複數個患者獲得之新鮮或冷凍腫瘤樣品。
- 如請求項12之方法,其中該等樣品包含自複數個患者獲得之新鮮或冷凍組織樣品。
- 如請求項12之方法,其中該等樣品包含利用T細胞分析辨識之肽。
- 如請求項12之方法,其中該訓練數據集進一步包含與以下相關之數據:存在於該等樣品中之訓練肽集之肽豐度;該等樣品中訓練肽集之肽長度。
- 如請求項12之方法,其中該訓練數據集係經由與包含已知蛋白質序列集之數據庫比對比較該訓練肽序列集來產生,其中該訓練蛋白質序列集長於且包括該等訓練肽序列。
- 如請求項12之方法,其中該訓練數據集係基於對細胞系實施或已實施質譜以獲得該細胞系之外顯子體、轉錄體或全基因體肽測序數據中之至少一者來產生,該肽測序數據包括至少一個包括變化之蛋白質序列。
- 如請求項12之方法,其中該訓練數據集係基於獲得正常組織樣品之外顯子體、轉錄體及全基因體正常核苷酸測序數據中之至少一者來產生。
- 如請求項12之方法,其中該訓練數據集進一步包含與該等樣品相關之蛋白質體序列相關之數據。
- 如請求項12之方法,其中該訓練數據集進一步包含與該等樣品相關 之MHC肽體序列相關之數據。
- 如請求項12之方法,其中該訓練數據集進一步包含與該等分離肽中之至少一者之肽-MHC結合親和力量測值相關之數據。
- 如請求項12之方法,其中該訓練數據集進一步包含與該等分離肽中之至少一者之肽-MHC結合穩定性量測值相關之數據。
- 如請求項12之方法,其中該訓練數據集進一步包含與該等樣品相關之轉錄體相關之數據。
- 如請求項12之方法,其中該訓練數據集進一步包含與該等樣品相關之基因體相關之數據。
- 如請求項12之方法,其中該訓練肽序列之長度介於k聚體範圍內,其中k介於8至15之間且包括8及15。
- 如請求項12之方法,其進一步包含利用獨熱(one-hot)編碼方案編碼該肽序列。
- 如請求項31之方法,其進一步包含利用左填充(left-padded)獨熱編碼方案編碼該等訓練肽序列。
- 一種製造腫瘤疫苗之方法,其包含實施如請求項1至32之任一步驟,且進一步包含產生或已產生包含經選擇新抗原集之腫瘤疫苗。
- 一種腫瘤疫苗,其包含藉由實施如請求項1至32中任一項之方法選擇之如請求項1至32中所定義之經選擇新抗原集。
- 如請求項34之疫苗,其中該腫瘤疫苗包含核苷酸序列、多肽序列、RNA、DNA、細胞、質體或載體中之一或多者。
- 如請求項34至35中任一項之疫苗,其中該腫瘤疫苗包含一或多種呈遞於該腫瘤細胞表面上之新抗原。
- 如請求項34至35中任一項之疫苗,其中該腫瘤疫苗包含一或多種在該個體中有免疫原性之新抗原。
- 如請求項34至35中任一項之疫苗,其中該腫瘤疫苗不包含一或多種誘導針對該個體中正常組織之自體免疫反應的新抗原。
- 如請求項34至35中任一項之疫苗,其中該腫瘤疫苗進一步包含佐劑。
- 如請求項34至35中任一項之疫苗,其中該腫瘤疫苗進一步包含賦形劑。
- 如請求項34至40中任一項之腫瘤疫苗之用途,其係製造用於治療具有腫瘤個體之藥物。
- 如請求項1至2中任一項之方法,其中選擇該經選擇新抗原集包含基於該呈遞模型選擇相對於未經選擇之新抗原具有增加的呈遞於該腫瘤細胞表面上之似然度的新抗原。
- 如請求項1至2中任一項之方法,其中選擇該經選擇新抗原集包含基於該呈遞模型選擇相對於未經選擇之新抗原具有增加的能夠誘導該個體中腫瘤特異性免疫反應之似然度的新抗原。
- 如請求項1至2中任一項之方法,其中選擇該經選擇新抗原集包含基於該呈遞模型選擇相對於未經選擇之新抗原具有增加的能夠藉由專業抗原呈遞細胞(APCs)呈遞至原初(naïve)T細胞之似然度的新抗原,視情況其中該APC係樹突細胞(DC)。
- 如請求項1至2中任一項之方法,其中選擇該經選擇新抗原集包含基於該呈遞模型選擇相對於未經選擇之新抗原具有減小的經由中樞或周邊耐受性抑制之似然度的新抗原。
- 如請求項1至2中任一項之方法,其中選擇該經選擇新抗原集包含基於該呈遞模型選擇相對於未經選擇之新抗原具有減小的能夠誘導針對該個 體正常組織之自體免疫反應之似然度的新抗原。
- 如請求項1至2中任一項之方法,其中外顯子體或轉錄體核苷酸測序數據係藉由對腫瘤組織實施測序獲得。
- 如請求項1至2中任一項之方法,其中該測序係下一代測序(NGS)或任一大量平行測序方法。
- 如請求項1至2中任一項之方法,其中該數值似然度集係進一步藉由至少MHC對偶基因相互作用特徵來辨識,該等特徵包含以下中之至少一者:a.該MHC對偶基因及該新抗原編碼肽結合之預測親和力;b.該新抗原編碼肽-MHC複合體之預測穩定性;c.該新抗原編碼肽之序列及長度;d.具有相似序列之新抗原編碼肽在表現特定MHC對偶基因之其他個體細胞中之呈遞機率,如藉由質譜蛋白質體學或其他方式評估;e.在所討論個體中該特定MHC對偶基因之表現量;f.在表現該特定MHC對偶基因之其他不同個體中藉由該特定MHC對偶基因呈遞之總體新抗原編碼肽序列非依賴性機率;g.在其他不同個體中同一家族分子中藉由MHC對偶基因呈遞之總體新抗原編碼肽序列非依賴性機率。
- 如請求項49之方法,其中: 在所討論個體中該特定MHC對偶基因之表現量係藉由RNA-seq或質譜量測;及/或該同一家族分子包含HLA-A、HLA-B、HLA-C、HLA-DQ、HLA-DR或HLA-DP。
- 如請求項1至2中任一項之方法,其中該數值似然度集進一步藉由至少MHC對偶基因非相互作用特徵來辨識,該等特徵包含以下中之至少一者:a.在其源蛋白序列內側接該新抗原編碼肽之C端及N端序列;b.在該新抗原編碼肽中存在蛋白酶裂解基序,視情況根據相應蛋白酶在該等腫瘤細胞中之表現(如藉由RNA-seq或質譜量測)加權;c.如在適宜細胞類型中量測之該源蛋白之轉換率;d.該源蛋白之長度,視情況考慮該等腫瘤細胞中最高表現之特異性剪接變體(「異型體(isoforms)」),如藉由RNA-seq或蛋白質體質譜量測,或如根據在DNA或RNA序列數據中檢測之生殖系或體細胞剪接突變之註解所預測;e.該蛋白酶體、免疫蛋白酶體、胸腺蛋白酶體或其他蛋白酶在該等腫瘤細胞中之表現量(其可藉由RNA-seq、蛋白質體質譜或免疫組織化學量測);f.該新抗原編碼肽之源基因之表現;g.該新抗原編碼肽之源基因在細胞週期之各個階段期間之典型組織特異性表現;h.該源蛋白及/或其結構域之特徵之總目(comprehensive catalog);i.闡述含有該肽之源蛋白之結構域性質的特徵;j.所討論該新抗原編碼肽之源蛋白之肽在其他不同個體中之呈遞機率;k.因技術偏差無法藉由質譜檢測或過表(over-represented)該肽之機率;l.如藉由RNASeq所量測之多個基因模組/路徑(其無需含有該肽之源蛋白)之表現,其為該等腫瘤細胞、基質或腫瘤浸潤淋巴球(TILs)之狀態之資訊;m.該等腫瘤細胞中該新抗原編碼肽之源基因之拷貝數;n.該肽結合至TAP之機率或經量測或預測之該肽與該TAP之結合親和力;o. TAP在該等腫瘤細胞中之表現量(其可藉由RNA-seq、蛋白質體質譜、免疫組織化學量測);p.存在或不存在腫瘤突變,其包括(但不限於):i.在已知癌症驅動基因(諸如EGFR、KRAS、ALK、RET、ROS1、TP53、CDKN2A、CDKN2B、NTRK1、NTRK2、NTRK3)中之驅動突變ii.在編碼參與抗原呈遞機制之蛋白質之基因中;依賴該抗原呈遞機制之一個在該腫瘤中經功能喪失突變之組份呈遞的肽具有減小的呈遞機率;q.存在或不存在功能生殖系多型性,其包括(但不限於):i.在編碼參與該抗原呈遞機制之蛋白質之基因中; r.腫瘤類型;s.臨床腫瘤亞型;t.吸煙史;u.該肽之源基因在相關腫瘤類型或臨床亞型中之典型表現,視情況藉由驅動突變分層。
- 如請求項51之方法,其中:該新抗原編碼肽之源基因之表現係藉由RNA-seq或質譜量測;該源蛋白及/或其結構域之特徵之總目(comprehensive catalog)係可見於uniProt或PDB http://www.rcsb.org/pdb/home/home.do;該闡述含有該肽之源蛋白之結構域性質的特徵係二級或三級結構或選擇式剪接;該編碼參與抗原呈遞機制之蛋白質之基因包含B2M、HLA-A、HLA-B、HLA-C、TAP-1、TAP-2、TAPBP、CALR、CNX、ERP57、HLA-DM、HLA-DMA、HLA-DMB、HLA-DO、HLA-DOA、HLA-DOBHLA-DP、HLA-DPA1、HLA-DPB1、HLA-DQ、HLA-DQA1、HLA-DQA2、HLA-DQB1、HLA-DQB2、HLA-DR、HLA-DRA、HLA-DRB1、HLA-DRB3、HLA-DRB4、HLA-DRB5或編碼該蛋白酶體或免疫蛋白酶體組份之基因中的任一者;該腫瘤類型係NSCLC或黑色素瘤;及/或該臨床腫瘤亞型係鱗狀肺癌對非鱗狀。
- 如請求項52之方法,其中該二級或三級結構係α螺旋對β褶板。
- 如請求項1至2中任一項之方法,其中該至少一個突變係框移或非框移插入/缺失(indel)、誤義或無義取代、剪接位點變化、基因體重排或基因融合,或產生新ORF之任何基因體或表現變化。
- 如請求項1至2中任一項之方法,其中該腫瘤細胞選自由以下組成之群:肺癌、黑色素瘤、乳癌、卵巢癌、前列腺癌、腎癌、胃癌、結腸癌、睪丸癌、頭頸癌、胰臟癌、腦癌、B細胞淋巴瘤、急性骨髓性白血病、慢性骨髓性白血病、慢性淋巴球性白血病及T細胞淋巴球性白血病、非小細胞肺癌及小細胞肺癌。
- 如請求項1至2中任一項之方法,其進一步包含獲得包含該經選擇新抗原集或其子集之腫瘤疫苗,其視情況進一步包含向該個體投與該腫瘤疫苗。
- 如請求項1至2中任一項之方法,其中該經選擇新抗原集中之至少一種新抗原在呈多肽形式時包含以下中之至少一者:與MHC之結合親和力之IC50值小於1000nM;對於1類MHC多肽,長度為8至15個,8個、9個、10個、11個、12個、13個、14個或15個胺基酸;在親代蛋白質序列中之多肽內或附近存在促進蛋白酶體裂解之序列基序;及存在促進TAP轉運之序列基序。
- 一種產生用於辨識一或多種可能呈遞於腫瘤細胞之腫瘤細胞表面上 新抗原之模型的方法,其包含執行以下步驟:接收質譜數據,其包含與源自複數個樣品之主要組織相容性複合體(MHC)溶析之複數個分離肽相關之數據;藉由至少辨識存在於該等樣品中且呈遞於一或多個與每一訓練肽序列相關之MHC上之訓練肽序列來獲得訓練數據集;利用包含該等訓練肽序列之訓練數據集訓練呈遞模型之數值參數集,該呈遞模型提供該腫瘤細胞之肽序列由該腫瘤細胞表面上之一或多個MHC對偶基因呈遞之複數種數值似然度。
- 如請求項58之方法,其中該呈遞模型代表以下之間之依賴性:肽序列特定位置之特定胺基酸之存在;與藉由該腫瘤細胞上之MHC對偶基因中之一者,含有該特定位置之特定胺基酸之肽序列的呈遞似然度。
- 如請求項58至59中任一項之方法,其中該等樣品包含經改造以表現單一I類或II類MHC對偶基因之細胞系。
- 如請求項58至59中任一項之方法,其中該等樣品包含經改造以表現複數個I類或II類MHC對偶基因之細胞系。
- 如請求項58至59中任一項之方法,其中該等樣品包含獲自或源自複數個患者之人類細胞系。
- 如請求項58至59中任一項之方法,其中該等樣品包含自複數個患者獲得之新鮮或冷凍腫瘤樣品。
- 如請求項58至59中任一項之方法,其中該等樣品包含利用T細胞分析辨識之肽。
- 如請求項58至59中任一項之方法,其中該訓練數據集進一步包含與以下相關之數據:存在於該等樣品中之訓練肽集之肽豐度;該等樣品中訓練肽集之肽長度。
- 如請求項58至59中任一項之方法,其中獲得該訓練數據集包含:經由與包含已知蛋白質序列集之數據庫比對比較該訓練肽序列集來獲得基於該等訓練肽序列之訓練蛋白質序列集,其中該訓練蛋白質序列集長於且包括該等訓練肽序列。
- 如請求項58至59中任一項之方法,其中獲得該訓練數據集包含:對細胞系實施或已實施質譜以獲得該細胞系之外顯子體、轉錄體或全基因體核苷酸測序數據中之至少一者,該核苷酸測序數據包括至少一個包括突變之蛋白質序列。
- 如請求項58至59中任一項之方法,其中訓練該呈遞模型之參數集包含: 利用獨熱編碼方案編碼該等訓練肽序列。
- 如請求項58至59中任一項之方法,其進一步包含:獲得正常組織樣品之外顯子體、轉錄體及全基因體正常核苷酸測序數據中之至少一者;及利用該正常核苷酸測序數據訓練該呈遞模型之參數集。
- 如請求項58至59中任一項之方法,其中該訓練數據集進一步包含與該等樣品相關之蛋白質體序列相關之數據。
- 如請求項58至59中任一項之方法,其中該訓練數據集進一步包含與該等樣品相關之MHC肽體序列相關之數據。
- 如請求項58至59中任一項之方法,其中該訓練數據集進一步包含與該等分離肽中之至少一者之肽-MHC結合親和力量測值相關之數據。
- 如請求項58至59中任一項之方法,其中該訓練數據集進一步包含與該等分離肽中之至少一者之肽-MHC結合穩定性量測值相關之數據。
- 如請求項58至59中任一項之方法,其中該訓練數據集進一步包含與該等樣品相關之轉錄體相關之數據。
- 如請求項58至59中任一項之方法,其中該訓練數據集進一步包含與 該等樣品相關之基因體相關之數據。
- 如請求項58至59中任一項之方法,其中訓練該數值參數集進一步包含:使該參數集邏輯回歸。
- 如請求項58至59中任一項之方法,其中該等訓練肽序列之長度介於k聚體範圍內,其中k介於8至15之間且包括8及15。
- 如請求項58至59中任一項之方法,其中訓練該呈遞模型之數值參數集包含:利用左填充獨熱編碼方案編碼該等訓練肽序列。
- 如請求項58至59之方法,其中訓練該數值參數集進一步包含:利用深度學習演算法測定該參數集之值。
- 一種產生用於辨識一或多種可能呈遞於腫瘤細胞之腫瘤細胞表面上新抗原之模型的方法,其包含執行以下步驟:接收質譜數據,其包含與源自複數個新鮮或冷凍腫瘤樣品之主要組織相容性複合體(MHC)溶析之複數個分離肽相關之數據;藉由至少辨識存在於該等腫瘤樣品中且呈遞於一或多個與每一訓練肽序列相關之MHC對偶基因上之訓練肽序列集來獲得訓練數據集; 基於該等訓練肽序列獲得訓練蛋白質序列集;及利用該等訓練蛋白質序列及該等訓練肽序列訓練呈遞模型之數值參數集,該呈遞模型提供該腫瘤細胞之肽序列由該腫瘤細胞表面上之一或多個MHC對偶基因呈遞之複數個數值似然度。
- 如請求項80之方法,其中該呈遞模型代表以下之間之依賴性:該等MHC對偶基因中之特定一者及肽序列特定位置之特定胺基酸之對的存在;與藉由該對之MHC對偶基因中之特定一者,包含該特定位置之特定胺基酸之肽序列呈遞於該腫瘤細胞表面上之似然度。
- 一種用於辨識一或多種可能呈遞於細胞表面上之抗原之方法,其包含以下步驟:獲得肽序列;將該肽序列輸入一或多種呈遞模型中以產生該等肽序列由該細胞表面上之一或多個MHC對偶基因呈遞之數值似然度集(set of numerical likelihoods),該數值似然度集已至少基於所接收之質譜數據辨識;其中該一或多種呈遞模型係使用訓練數據集訓練,該訓練數據集包含:訓練肽序列,至少一個與該訓練肽序列相關之MHC對偶基因,以及指示一或多種訓練肽序列是否由該至少一個MHC對偶基因所呈遞之標記;及基於該數值似然度集選擇抗原。
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Families Citing this family (94)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2014113204A1 (en) | 2013-01-17 | 2014-07-24 | Personalis, Inc. | Methods and systems for genetic analysis |
WO2014180490A1 (en) | 2013-05-10 | 2014-11-13 | Biontech Ag | Predicting immunogenicity of t cell epitopes |
WO2015077717A1 (en) | 2013-11-25 | 2015-05-28 | The Broad Institute Inc. | Compositions and methods for diagnosing, evaluating and treating cancer by means of the dna methylation status |
WO2015085147A1 (en) | 2013-12-05 | 2015-06-11 | The Broad Institute Inc. | Polymorphic gene typing and somatic change detection using sequencing data |
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US11338026B2 (en) | 2014-09-10 | 2022-05-24 | The University Of Connecticut | Identification of immunologically protective neo-epitopes for the treatment of cancers |
WO2016100975A1 (en) | 2014-12-19 | 2016-06-23 | Massachsetts Institute Ot Technology | Molecular biomarkers for cancer immunotherapy |
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US11514289B1 (en) * | 2016-03-09 | 2022-11-29 | Freenome Holdings, Inc. | Generating machine learning models using genetic data |
US11299783B2 (en) | 2016-05-27 | 2022-04-12 | Personalis, Inc. | Methods and systems for genetic analysis |
RS62390B1 (sr) * | 2016-07-20 | 2021-10-29 | BioNTech SE | Izbor neoepitopa kao ciljeva specifičnih za bolest za terapiju sa povećanom efikasnošću |
CN106295678B (zh) * | 2016-07-27 | 2020-03-06 | 北京旷视科技有限公司 | 神经网络训练与构建方法和装置以及目标检测方法和装置 |
EP3494231A4 (en) * | 2016-08-02 | 2020-04-15 | Georgetown University | METHODS FOR IDENTIFYING NEW PROTEINS AND NEW ANTIGENS IN CANCER CELLS |
CA3045811A1 (en) | 2016-12-01 | 2018-06-07 | Nantomics, Llc | Tumor antigenicity processing and presentation |
CA3050109A1 (en) * | 2017-01-18 | 2018-07-26 | Ichan School Of Medicine At Mount Sinai | Neoantigens and uses thereof for treating cancer |
WO2018148671A1 (en) | 2017-02-12 | 2018-08-16 | Neon Therapeutics, Inc. | Hla-based methods and compositions and uses thereof |
EP3568811A1 (en) * | 2017-02-24 | 2019-11-20 | Deepmind Technologies Limited | Training machine learning models |
US20210113673A1 (en) * | 2017-04-19 | 2021-04-22 | Gritstone Oncology, Inc. | Neoantigen Identification, Manufacture, and Use |
JP2020518648A (ja) | 2017-05-08 | 2020-06-25 | グリットストーン オンコロジー インコーポレイテッド | アルファウイルス新生抗原ベクター |
SG11201912429RA (en) * | 2017-06-21 | 2020-01-30 | Transgene Sa | Personalized vaccine |
US20220293215A1 (en) * | 2017-06-27 | 2022-09-15 | The Broad Institute, Inc. | Systems and methods for mhc class ii epitope prediction |
EP3651791A1 (en) * | 2017-07-14 | 2020-05-20 | The Francis Crick Institute Limited | Analysis of hla alleles in tumours and the uses thereof |
EP3658683A4 (en) * | 2017-07-25 | 2021-04-21 | California Institute of Technology | TROGOCYTOSIS-MEDIATED EPITOPE DISCOVERY |
JP6928948B2 (ja) * | 2017-08-09 | 2021-09-01 | 学校法人日本大学 | 口臭判定装置及びプログラム |
US11969463B2 (en) * | 2017-08-10 | 2024-04-30 | Good T Cells, Inc. | Method for activating T cells for cancer treatment |
AU2018328220A1 (en) * | 2017-09-05 | 2020-04-23 | Gritstone Bio, Inc. | Neoantigen identification for T-cell therapy |
CN111465989B (zh) * | 2017-10-10 | 2024-06-25 | 磨石生物公司 | 使用热点进行的新抗原鉴别 |
SG10202108020VA (en) * | 2017-10-16 | 2021-09-29 | Illumina Inc | Deep learning-based techniques for training deep convolutional neural networks |
US11861491B2 (en) | 2017-10-16 | 2024-01-02 | Illumina, Inc. | Deep learning-based pathogenicity classifier for promoter single nucleotide variants (pSNVs) |
NZ759880A (en) * | 2017-10-16 | 2022-04-29 | Illumina Inc | Aberrant splicing detection using convolutional neural networks (cnns) |
CN111630602A (zh) * | 2017-11-22 | 2020-09-04 | 磨石肿瘤生物技术公司 | 减少新抗原的接合表位呈递 |
CN109682978B (zh) * | 2017-11-30 | 2020-07-03 | 四川康德赛医疗科技有限公司 | 一种肿瘤突变肽mhc亲和力预测方法及其应用 |
WO2019136309A1 (en) | 2018-01-04 | 2019-07-11 | Iconic Therapeutics, Inc. | Anti-tissue factor antibodies, antibody-drug conjugates, and related methods |
AU2019227813B2 (en) * | 2018-02-27 | 2024-06-27 | Gritstone Bio, Inc. | Neoantigen identification with pan-allele models |
WO2019173687A1 (en) * | 2018-03-08 | 2019-09-12 | The Trustees Of Indiana University | Constrained de novo sequencing of neo-epitope peptides using tandem mass spectrometry |
US20210158895A1 (en) * | 2018-04-13 | 2021-05-27 | Dana-Farber Cancer Institute, Inc. | Ultra-sensitive detection of cancer by algorithmic analysis |
KR102212663B1 (ko) * | 2018-05-22 | 2021-02-05 | 주식회사 석영시스템즈 | 목표 온도를 기반으로 하는 빌딩의 열·공조 시스템에 대한 공급 전력 제어 방법 및 장치 |
TW202000907A (zh) * | 2018-05-23 | 2020-01-01 | 美商葛利史東腫瘤科技公司 | 共有抗原 |
US10801064B2 (en) | 2018-05-31 | 2020-10-13 | Personalis, Inc. | Compositions, methods and systems for processing or analyzing multi-species nucleic acid samples |
US11814750B2 (en) | 2018-05-31 | 2023-11-14 | Personalis, Inc. | Compositions, methods and systems for processing or analyzing multi-species nucleic acid samples |
WO2020022897A1 (en) * | 2018-07-26 | 2020-01-30 | Frame Pharmaceuticals B.V. | Method of preparing subject-specific immunogenic compositions based on a neo open-reading-frame peptide database |
US20210382068A1 (en) * | 2018-10-02 | 2021-12-09 | Dana-Farber Cancer Institute, Inc. | Hla single allele lines |
US20220088174A1 (en) * | 2018-10-26 | 2022-03-24 | Dana-Farber Cancer Institute, Inc. | Genomic variants in ig gene regions and uses of same |
CA3117670A1 (en) * | 2018-10-29 | 2020-05-07 | Health Research, Inc. | Cancer specific immunotherapeutic targets generated by chemotherapeutic drug treatment |
JP7239300B2 (ja) * | 2018-11-01 | 2023-03-14 | 浜松ホトニクス株式会社 | スペクトル分析装置およびスペクトル分析方法 |
JP7477888B2 (ja) * | 2018-11-15 | 2024-05-02 | ノイスコム アーゲー | 個別化された癌ワクチンの作製のための癌変異の選択 |
KR20210064229A (ko) | 2018-11-21 | 2021-06-02 | 닛본 덴끼 가부시끼가이샤 | 신생항원-기반 면역요법을 위한 항원결정인자 표적화 방법 및 시스템 |
US20220076783A1 (en) * | 2018-12-20 | 2022-03-10 | Merck Sharp & Dohme Corp. | Methods and Systems for the Precise Identification of Immunogenic Tumor Neoantigens |
EP3897691A4 (en) * | 2018-12-21 | 2022-08-31 | The Regents of the University of California | IL-10 VACCINES AND THEIR USES |
EP3899954A4 (en) * | 2018-12-21 | 2022-09-14 | BioNTech US Inc. | METHODS AND SYSTEMS FOR PREDICTING HLA CLASS II SPECIFIC EPITOPES AND CHARACTERIZING CD4+ T CELLS |
CN109712672B (zh) * | 2018-12-29 | 2021-05-25 | 北京优迅医学检验实验室有限公司 | 检测基因重排的方法、装置、存储介质及处理器 |
CN109706065A (zh) * | 2018-12-29 | 2019-05-03 | 深圳裕策生物科技有限公司 | 肿瘤新生抗原负荷检测装置及存储介质 |
CA3124905A1 (en) | 2019-01-03 | 2020-07-09 | Jens KRINGELUM | Vaccines targeting neoepitopes |
CN110675913B (zh) * | 2019-01-16 | 2022-04-12 | 倍而达药业(苏州)有限公司 | 一种基于hla分型与结构的肿瘤新抗原的筛选方法 |
CN109801678B (zh) * | 2019-01-25 | 2023-07-25 | 上海鲸舟基因科技有限公司 | 基于全转录组的肿瘤抗原预测方法及其应用 |
EP3918069A1 (en) * | 2019-01-31 | 2021-12-08 | Bar Ilan University | Neoantigens created by aberrant-induced splicing and uses thereof in enhancing immunotherapy |
KR20210125523A (ko) * | 2019-02-11 | 2021-10-18 | 플래그쉽 파이어니어링 이노베이션스 브이아이, 엘엘씨 | 기계 학습 안내된 폴리펩티드 분석 |
BR112021016451A2 (pt) | 2019-02-20 | 2021-11-09 | Rubius Therapeutics Inc | Célula eritroide projetada incluindo polipeptídeos apresentadores de antígeno carregáveis e métodos de uso |
CN111621564B (zh) * | 2019-02-28 | 2022-03-25 | 武汉大学 | 一种鉴定有效肿瘤新抗原的方法 |
CA3132041A1 (en) * | 2019-03-06 | 2020-09-10 | Gritstone Bio, Inc. | Identification of neoantigens with mhc class ii model |
CA3131824A1 (en) | 2019-03-11 | 2020-09-17 | Birgitte Rono | Nucleic acid vaccination using neo-epitope encoding constructs |
CN111696628A (zh) * | 2019-03-15 | 2020-09-22 | 痕准生物科技有限公司 | 新生抗原的鉴定方法 |
US11599774B2 (en) * | 2019-03-29 | 2023-03-07 | International Business Machines Corporation | Training machine learning model |
WO2020243719A1 (en) | 2019-05-30 | 2020-12-03 | Gritstone Oncology, Inc. | Modified adenoviruses |
CN110172513A (zh) * | 2019-05-30 | 2019-08-27 | 浙江自贸区锐赛生物医药科技有限公司 | 突变型免疫多肽临床入组的筛选方法 |
EP3993829A4 (en) * | 2019-07-02 | 2024-01-03 | Gritstone bio, Inc. | HIV ANTIGENS AND MHC COMPLEXES |
KR20220047277A (ko) | 2019-07-16 | 2022-04-15 | 길리애드 사이언시즈, 인코포레이티드 | Hiv 백신, 및 이의 제조 및 사용 방법 |
WO2021048400A1 (en) | 2019-09-13 | 2021-03-18 | Evaxion Biotech Aps | Method for identifying t-cell epitopes |
CN110706747B (zh) * | 2019-09-17 | 2021-09-07 | 北京橡鑫生物科技有限公司 | 检测肿瘤新生抗原多肽的方法和装置 |
CN110456079B (zh) * | 2019-09-20 | 2020-06-02 | 四川大学华西医院 | Tapbp自身抗体检测试剂在制备肺癌筛查试剂盒中的用途 |
US20210104294A1 (en) * | 2019-10-02 | 2021-04-08 | The General Hospital Corporation | Method for predicting hla-binding peptides using protein structural features |
CA3161242A1 (en) | 2019-12-18 | 2021-06-24 | Birgitte Rono | Nucleic acid vaccination using neo-epitope encoding constructs |
KR102278586B1 (ko) * | 2020-01-07 | 2021-07-16 | 한국과학기술원 | 신생항원을 스크리닝하는 방법, 시스템 및 그의 용도 |
CN111303268B (zh) * | 2020-03-10 | 2021-08-27 | 江苏兰恩生物治疗技术研究院有限公司 | 子宫肌瘤新抗原、其应用和子宫肌瘤疫苗 |
AU2021253641A1 (en) | 2020-04-07 | 2022-10-27 | Evaxion Biotech A/S | Neoepitope immunotherapy with APC targeting unit |
US11920202B2 (en) | 2020-04-09 | 2024-03-05 | University Of Connecticut | Unbiased identification of tumor rejection mediating neoepitopes |
EP4143830A1 (en) * | 2020-04-27 | 2023-03-08 | Flagship Pioneering Innovations VI, LLC | Optimizing proteins using model based optimizations |
AU2021273827A1 (en) * | 2020-05-19 | 2023-01-19 | Gritstone Bio, Inc. | SARS-CoV-2 vaccines |
JP2023533871A (ja) | 2020-07-14 | 2023-08-04 | エヴァクシオン・バイオテック・アクティエセルスカブ | 免疫療法のためのapc標的化単位 |
CN115836350A (zh) | 2020-07-14 | 2023-03-21 | 米尼奥公司 | 用于确定新抗原的呈递可能性的方法、系统和计算机程序产品 |
AU2021320896A1 (en) | 2020-08-06 | 2023-03-23 | Gritstone Bio, Inc. | Multiepitope vaccine cassettes |
US20220139498A1 (en) * | 2020-11-04 | 2022-05-05 | Basf Corporation | Apparatuses, systems, and methods for extracting meaning from dna sequence data using natural language processing (nlp) |
CN116802738A (zh) * | 2020-11-06 | 2023-09-22 | 亚马逊科技公司 | 为个体化癌症疫苗选择新抗原 |
US20220319635A1 (en) * | 2021-04-05 | 2022-10-06 | Nec Laboratories America, Inc. | Generating minority-class examples for training data |
CN113129998B (zh) * | 2021-04-23 | 2022-06-21 | 云测智能科技有限公司 | 临床个体化肿瘤新抗原的预测模型构建方法 |
WO2022229966A1 (en) | 2021-04-29 | 2022-11-03 | Yeda Research And Development Co. Ltd. | T cell receptors directed against ras-derived recurrent neoantigens and methods of identifying same |
KR20240026905A (ko) | 2021-04-30 | 2024-02-29 | 티젠 파마 에스에이 | 림프구의 단일 용기 확장 |
CN113807468B (zh) * | 2021-10-15 | 2022-05-27 | 南京澄实生物科技有限公司 | 基于多模态深度编码的hla抗原呈递预测方法和系统 |
CN113762416B (zh) * | 2021-10-15 | 2023-05-30 | 南京澄实生物科技有限公司 | 基于多模态深度编码的抗原免疫原性预测方法和系统 |
WO2023177655A1 (en) | 2022-03-14 | 2023-09-21 | Generation Bio Co. | Heterologous prime boost vaccine compositions and methods of use |
TWI805290B (zh) * | 2022-03-28 | 2023-06-11 | 臺北醫學大學 | 用於預測肺腺癌是否具有表皮生長因子受體突變的方法 |
US20230368872A1 (en) * | 2022-05-16 | 2023-11-16 | Spencer Health Solutions, Llc | Alert decision support system based on patient quality of life survey information and related methods and computer program products |
WO2024097864A1 (en) | 2022-11-02 | 2024-05-10 | Tigen Pharma Sa | Expansion of lymphocytes |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103180730A (zh) * | 2010-05-14 | 2013-06-26 | 综合医院公司 | 鉴定肿瘤特异性新抗原的组合物和方法 |
Family Cites Families (235)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4235871A (en) | 1978-02-24 | 1980-11-25 | Papahadjopoulos Demetrios P | Method of encapsulating biologically active materials in lipid vesicles |
US4722848A (en) | 1982-12-08 | 1988-02-02 | Health Research, Incorporated | Method for immunizing animals with synthetically modified vaccinia virus |
US4452773A (en) | 1982-04-05 | 1984-06-05 | Canadian Patents And Development Limited | Magnetic iron-dextran microspheres |
US4501728A (en) | 1983-01-06 | 1985-02-26 | Technology Unlimited, Inc. | Masking of liposomes from RES recognition |
GB8311018D0 (en) | 1983-04-22 | 1983-05-25 | Amersham Int Plc | Detecting mutations in dna |
US5019369A (en) | 1984-10-22 | 1991-05-28 | Vestar, Inc. | Method of targeting tumors in humans |
US4795698A (en) | 1985-10-04 | 1989-01-03 | Immunicon Corporation | Magnetic-polymer particles |
US4837028A (en) | 1986-12-24 | 1989-06-06 | Liposome Technology, Inc. | Liposomes with enhanced circulation time |
US5204244A (en) | 1987-10-27 | 1993-04-20 | Oncogen | Production of chimeric antibodies by homologous recombination |
WO1990007380A2 (en) | 1988-12-28 | 1990-07-12 | Stefan Miltenyi | Methods and materials for high gradient magnetic separation of biological materials |
US5703055A (en) | 1989-03-21 | 1997-12-30 | Wisconsin Alumni Research Foundation | Generation of antibodies through lipid mediated DNA delivery |
US5581080A (en) | 1989-05-19 | 1996-12-03 | Fenn; John B. | Method for determining molecular weight using multiply charged ions |
US5130538A (en) | 1989-05-19 | 1992-07-14 | John B. Fenn | Method of producing multiply charged ions and for determining molecular weights of molecules by use of the multiply charged ions of molecules |
EP0434792A4 (en) | 1989-05-19 | 1992-05-20 | John B. Fenn | Multiply charged ions and a method for determining the molecular weight of large molecules |
FR2650840B1 (fr) | 1989-08-11 | 1991-11-29 | Bertin & Cie | Procede rapide de detection et/ou d'identification d'une seule base sur une sequence d'acide nucleique, et ses applications |
ATE157012T1 (de) | 1989-11-03 | 1997-09-15 | Univ Vanderbilt | Verfahren zur in vivo-verabreichung von funktionsfähigen fremden genen |
JP3949711B2 (ja) | 1990-02-26 | 2007-07-25 | ザ ボード オブ トラスティーズ オブ ザ リーランド スタンフォード ジュニア ユニバーシティ | 昆虫ステロイドレセプターdna配列の同定及び発現 |
US5279833A (en) | 1990-04-04 | 1994-01-18 | Yale University | Liposomal transfection of nucleic acids into animal cells |
US5204253A (en) | 1990-05-29 | 1993-04-20 | E. I. Du Pont De Nemours And Company | Method and apparatus for introducing biological substances into living cells |
US5200084A (en) | 1990-09-26 | 1993-04-06 | Immunicon Corporation | Apparatus and methods for magnetic separation |
US6004744A (en) | 1991-03-05 | 1999-12-21 | Molecular Tool, Inc. | Method for determining nucleotide identity through extension of immobilized primer |
WO1993024640A2 (en) | 1992-06-04 | 1993-12-09 | The Regents Of The University Of California | Methods and compositions for in vivo gene therapy |
US5608217A (en) | 1994-03-10 | 1997-03-04 | Bruker-Franzen Analytik Gmbh | Electrospraying method for mass spectrometric analysis |
DE4444229C2 (de) | 1994-03-10 | 1996-07-25 | Bruker Franzen Analytik Gmbh | Verfahren und Vorrichtungen zur Elektrosprüh-Ionisierung für speichernde Massenspektometer |
US5534615A (en) | 1994-04-25 | 1996-07-09 | Genentech, Inc. | Cardiac hypertrophy factor and uses therefor |
US5827642A (en) | 1994-08-31 | 1998-10-27 | Fred Hutchinson Cancer Research Center | Rapid expansion method ("REM") for in vitro propagation of T lymphocytes |
US8956621B2 (en) | 1994-11-08 | 2015-02-17 | The Trustees Of The University Of Pennsylvania | Compositions and methods for treatment of cervical dysplasia |
US8114414B2 (en) | 1994-11-08 | 2012-02-14 | The Trustees Of The University Of Pennsylvania | Compositions and methods for treatment of cervical cancer |
US6071890A (en) | 1994-12-09 | 2000-06-06 | Genzyme Corporation | Organ-specific targeting of cationic amphiphile/DNA complexes for gene therapy |
US5849589A (en) | 1996-03-11 | 1998-12-15 | Duke University | Culturing monocytes with IL-4, TNF-α and GM-CSF TO induce differentiation to dendric cells |
EP1021537A1 (en) | 1997-10-10 | 2000-07-26 | Basf Ag | T cell receptor-associated molecules (trams) and methods of use therefor |
DE19937828C1 (de) | 1999-08-11 | 2000-10-05 | Smb Schwede Maschinenbau Gmbh | Schweißkopf für eine Bandumreifungsmaschine |
WO2001025268A1 (en) | 1999-10-04 | 2001-04-12 | Schrotz King Petra | Human seizure related proteins |
MXPA02009157A (es) | 2000-03-22 | 2004-04-05 | Rohm & Haas | Nuevo sistema de expresion genetica inducible a base del receptor de ecdisona. |
US9012141B2 (en) | 2000-03-27 | 2015-04-21 | Advaxis, Inc. | Compositions and methods comprising KLK3 of FOLH1 antigen |
CA2413211A1 (en) * | 2000-04-04 | 2001-10-11 | University Of Rochester | A gene differentially expressed in breast and bladder cancer and encoded polypeptides |
AU2001270941A1 (en) | 2000-06-09 | 2001-12-17 | Mds Proteomics, Inc. | Labeling of proteomic samples during proteolysis for quantitation and sample multiplexing |
GB0018901D0 (en) * | 2000-08-03 | 2000-09-20 | Biovation Ltd | Peptides presented by cells |
AU2002234171A1 (en) | 2000-10-25 | 2002-05-15 | Mds Proteomics, Inc. | Detection of modified amino acids by mass spectrometry |
ES2390425T3 (es) | 2000-12-22 | 2012-11-12 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | Uso de moléculas de orientación repulsivas (RGM) y sus moduladores |
US8771702B2 (en) | 2001-03-26 | 2014-07-08 | The Trustees Of The University Of Pennsylvania | Non-hemolytic LLO fusion proteins and methods of utilizing same |
AU2002256173A1 (en) | 2001-04-09 | 2002-10-21 | Mds Proteomics, Inc. | Methods and systems for searching genomic databases |
US7731648B2 (en) | 2001-07-25 | 2010-06-08 | Aduro Biotech | Magnetic nanoscale particle compositions, and therapeutic methods related thereto |
AU2002343601A1 (en) | 2001-10-31 | 2003-05-12 | Mds Proteomics, Inc. | Proteins involved in regulation of adipocytes and uses related thereto |
DE10211088A1 (de) | 2002-03-13 | 2003-09-25 | Ugur Sahin | Differentiell in Tumoren exprimierte Genprodukte und deren Verwendung |
AU2003232485A1 (en) | 2002-04-18 | 2003-10-27 | Mtm Laboratories Ag | Neopeptides and methods useful for detection and treatment of cancer |
US20050221350A1 (en) | 2002-05-29 | 2005-10-06 | Toni Weinschenk | Method for identifying immunoreactive peptides |
US7176022B2 (en) | 2002-12-20 | 2007-02-13 | Cell Genesys, Inc. | Directly injectable formulations which provide enhanced cryoprotection of cell products |
AU2004224425B2 (en) | 2003-02-06 | 2010-06-24 | Aduro Biotech | Modified free-living microbes, vaccine compositions and methods of use thereof |
ES2382332T3 (es) | 2003-02-06 | 2012-06-07 | Aduro Biotech | Listeria atenuada para entrar en células no fagocíticas, vacunas que comprenden esta listeria y métodos de uso de las mismas |
US7695725B2 (en) | 2003-02-06 | 2010-04-13 | Aduro Biotech | Modified free-living microbes, vaccine compositions and methods of use thereof |
AU2004268497A1 (en) | 2003-02-28 | 2005-03-10 | Antigenics Inc. | Use of lectins to promote oligomerization of glycoproteins and antigenic molecules |
US20040197312A1 (en) | 2003-04-02 | 2004-10-07 | Marina Moskalenko | Cytokine-expressing cellular vaccine combinations |
DE10341812A1 (de) | 2003-09-10 | 2005-04-07 | Ganymed Pharmaceuticals Ag | Differentiell in Tumoren exprimierte Genprodukte und deren Verwendung |
DE10344799A1 (de) | 2003-09-26 | 2005-04-14 | Ganymed Pharmaceuticals Ag | Identifizierung von Oberflächen-assoziierten Antigenen für die Tumordiagnose und -therapie |
AU2004314347B2 (en) | 2003-12-24 | 2011-05-19 | Aduro Biotech, Inc. | Recombinant nucleic acid molecules encoding fusion proteins comprising antigens and bacterial secretory signal polypeptides, expression cassettes, and bacteria, and methods of use thereof |
US7842289B2 (en) | 2003-12-24 | 2010-11-30 | Aduro Biotech | Recombinant nucleic acid molecules, expression cassettes, and bacteria, and methods of use thereof |
DE102004023187A1 (de) | 2004-05-11 | 2005-12-01 | Ganymed Pharmaceuticals Ag | Identifizierung von Oberflächen-assoziierten Antigenen für die Tumordiagnose und -therapie |
US20070265818A1 (en) | 2004-08-24 | 2007-11-15 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Computational methods and systems for heightening cell-mediated immune response |
US20060095241A1 (en) | 2004-10-29 | 2006-05-04 | Microsoft Corporation | Systems and methods that utilize machine learning algorithms to facilitate assembly of aids vaccine cocktails |
US7220549B2 (en) | 2004-12-30 | 2007-05-22 | Helicos Biosciences Corporation | Stabilizing a nucleic acid for nucleic acid sequencing |
US7283337B2 (en) | 2005-03-04 | 2007-10-16 | Headway Technologies, Inc. | Abutted exchange bias design for sensor stabilization |
DE102005013846A1 (de) | 2005-03-24 | 2006-10-05 | Ganymed Pharmaceuticals Ag | Identifizierung von Oberflächen-assoziierten Antigenen für die Tumordiagnose und -therapie |
EP1806359B1 (en) | 2005-09-05 | 2010-03-17 | Immatics Biotechnologies GmbH | Tumor-associated peptides binding promiscuously to human leukocyte antigen (HLA) class II molecules |
EP1762575A1 (en) | 2005-09-12 | 2007-03-14 | Ganymed Pharmaceuticals AG | Identification of tumor-associated antigens for diagnosis and therapy |
US9732131B2 (en) | 2006-02-27 | 2017-08-15 | Calviri, Inc. | Identification and use of novopeptides for the treatment of cancer |
JP2009532664A (ja) | 2006-02-27 | 2009-09-10 | アリゾナ・ボード・オブ・リージェンツ・フォー・アンド・オン・ビハーフ・オブ・アリゾナ・ステイト・ユニバーシティ | 癌の治療のためのノボペプチドの同定および使用 |
US7935804B2 (en) | 2006-03-01 | 2011-05-03 | Aduro Biotech | Engineered Listeria and methods of use thereof |
WO2007103225A2 (en) | 2006-03-01 | 2007-09-13 | Anza Therapeutics, Inc. | Engineered listeria and methods of use thereof |
US7919079B2 (en) | 2006-03-31 | 2011-04-05 | Biosante Pharmaceuticals, Inc. | Cancer immunotherapy compositions and methods of use |
US8768629B2 (en) | 2009-02-11 | 2014-07-01 | Caris Mpi, Inc. | Molecular profiling of tumors |
DE102006032362A1 (de) | 2006-07-13 | 2008-01-17 | Khd Humboldt Wedag Gmbh | Rollenpresse insbesondere zur Gutbettzerkleinerung |
US8926993B2 (en) | 2006-07-17 | 2015-01-06 | Aduro Biotech | Methods and compositions using Listeria for enhancing immunogenicity by prime boost |
US8121797B2 (en) | 2007-01-12 | 2012-02-21 | Microsoft Corporation | T-cell epitope prediction |
US9085638B2 (en) | 2007-03-07 | 2015-07-21 | The Johns Hopkins University | DNA vaccine enhancement with MHC class II activators |
US20090004213A1 (en) | 2007-03-26 | 2009-01-01 | Immatics Biotechnologies Gmbh | Combination therapy using active immunotherapy |
CN101765434B (zh) | 2007-07-27 | 2014-12-17 | 伊玛提克斯生物技术有限公司 | 抗肿瘤相关肽及相关抗癌疫苗组合物 |
EP2562182B1 (en) | 2007-07-27 | 2015-10-07 | Immatics Biotechnologies GmbH | Novel immunogenic epitopes for immunotherapy |
SI2660248T1 (sl) | 2007-07-27 | 2015-10-30 | Immatics Biotechnologies Gmbh | Nova imunoterapija proti možganskim tumorjem |
EP2201023A2 (en) | 2007-09-14 | 2010-06-30 | GENimmune N.V. | Affinity tag |
EP2060583A1 (en) | 2007-10-23 | 2009-05-20 | Ganymed Pharmaceuticals AG | Identification of tumor-associated markers for diagnosis and therapy |
ATE528077T1 (de) | 2007-12-07 | 2011-10-15 | Miltenyi Biotec Gmbh | Zentrifuge zur trennung einer probe in mindestens zwei komponenten |
EP2091046A1 (en) | 2008-02-15 | 2009-08-19 | Thomson Licensing | Presentation system and method for controlling the same |
SI2113253T1 (sl) | 2008-04-30 | 2010-06-30 | Immatics Biotechnologies Gmbh | Nove formulacije s tumorjem povezanih peptidov ki se vežejo na molekule humanega levkocitnega antigena HLA razreda I ali II za cepiva |
US20120164718A1 (en) | 2008-05-06 | 2012-06-28 | Innovative Micro Technology | Removable/disposable apparatus for MEMS particle sorting device |
DK2119726T5 (en) | 2008-05-14 | 2018-03-26 | Immatics Biotechnologies Gmbh | Novel and powerful MHC class II peptides derived from survivin and neurocan |
WO2009143085A1 (en) | 2008-05-19 | 2009-11-26 | Anza Therapeutics, Inc. | Compositions comprising prfa*mutant listeria and methods of use thereof |
US20150366955A9 (en) | 2009-11-11 | 2015-12-24 | Advaxis, Inc. | Compositions and methods for prevention of escape mutation in the treatment of her2/neu over-expressing tumors |
US20140234370A1 (en) | 2009-11-11 | 2014-08-21 | Advaxis, Inc. | Compositions and methods for prevention of escape mutation in the treatment of her2/neu over-expressing tumors |
US9650639B2 (en) | 2008-05-19 | 2017-05-16 | Advaxis, Inc. | Dual delivery system for heterologous antigens |
US9084747B2 (en) | 2009-11-11 | 2015-07-21 | Advaxis, Inc. | Compositions and methods for prevention of escape mutation in the treatment of HER2/NEU over-expressing tumors |
US9017660B2 (en) | 2009-11-11 | 2015-04-28 | Advaxis, Inc. | Compositions and methods for prevention of escape mutation in the treatment of Her2/neu over-expressing tumors |
EP2288379A4 (en) | 2008-05-19 | 2012-08-08 | Advaxis | DOUBLE RELEASE SYSTEM FOR HETEROLOGIST ANTIGENE |
US8840881B2 (en) | 2008-08-28 | 2014-09-23 | Aduro Gvax Inc. | Methods and compositions for treating prostate cancer or inducing a humoral immune response against prostate cancer |
GB2467691A (en) | 2008-09-05 | 2010-08-11 | Aueon Inc | Methods for stratifying and annotating cancer drug treatment options |
RS53782B1 (en) | 2008-10-01 | 2015-06-30 | Immatics Biotechnologies Gmbh | TUMOR-ASSOCIATED PEPTIDES PREPARED AND ANTI-CHANGE RESPONSE FOR GLIOBLASTOMA (GBM) AND OTHER CANCER TREATMENTS |
RU2017138373A (ru) | 2008-11-21 | 2019-02-11 | Юнивёрсити Оф Копенгаген | Праймирование иммунного ответа |
SI2403528T1 (sl) | 2009-03-02 | 2016-07-29 | Aduro Biotech Holdings, Europe B.V. | Protitelesa proti proliferacijo inducirajočemu ligandu (april) |
EP3138854B1 (en) | 2009-03-10 | 2022-01-26 | Baylor Research Institute | Antibodies against cd40 |
EP2409155A1 (en) | 2009-03-15 | 2012-01-25 | Technion Research and Development Foundation, Ltd. | Soluble hla complexes for use in disease diagnosis |
WO2010115118A2 (en) | 2009-04-03 | 2010-10-07 | Antigenics, Inc. | Methods for preparing and using multichaperone-antigen complexes |
EP2309262A1 (en) | 2009-10-06 | 2011-04-13 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Method for quantifying biomolecules |
WO2011100754A1 (en) | 2010-02-15 | 2011-08-18 | The Trustees Of The University Of Pennsylvania | Live listeria-based vaccines for central nervous system therapy |
GB201004551D0 (en) | 2010-03-19 | 2010-05-05 | Immatics Biotechnologies Gmbh | NOvel immunotherapy against several tumors including gastrointestinal and gastric cancer |
GB201004575D0 (en) | 2010-03-19 | 2010-05-05 | Immatics Biotechnologies Gmbh | Composition of tumor associated peptides and related anti cancer vaccine for the treatment of gastric cancer and other cancers |
EP2576791B8 (en) | 2010-05-23 | 2016-12-21 | Aduro BioTech, Inc. | Methods and compositions using listeria for adjuvant treatment of cancer |
AU2011258513A1 (en) | 2010-05-24 | 2012-11-29 | Agenus Inc. | Class I MHC phosphopeptides for cancer immunotherapy and diagnosis |
AU2011275749C1 (en) | 2010-07-09 | 2015-09-17 | Aduro Biotech Holdings, Europe B.V. | Agonistic antibody to CD27 |
US20130303594A1 (en) | 2010-09-14 | 2013-11-14 | Max-Planok-Gesellschaft Zur Forderung Der Wissenschaften E.V. | Hot1 and uses thereof |
GB201015765D0 (en) | 2010-09-21 | 2010-10-27 | Immatics Biotechnologies Gmbh | Use of myeloid cell biomarkers for the diagnosis of cancer |
WO2012138377A2 (en) | 2010-10-01 | 2012-10-11 | Trustees Of The University Of Pennsylvania | The use of listeria vaccine vectors to reverse vaccine unresponsiveness in parasitically infected individuals |
WO2012068360A1 (en) | 2010-11-17 | 2012-05-24 | Aduro Biotech | Methods and compositions for inducing an immune response to egfrviii |
GB201021289D0 (en) | 2010-12-15 | 2011-01-26 | Immatics Biotechnologies Gmbh | Novel biomarkers for a prediction of the outcome of an immunotherapy against cancer |
KR20190100425A (ko) | 2010-12-30 | 2019-08-28 | 파운데이션 메디신 인코포레이티드 | 종양 샘플의 다유전자 분석의 최적화 |
EP2683400A4 (en) | 2011-03-11 | 2014-09-17 | Advaxis | ADJUVANZIA ON LISTERIA BASE |
EP2508537A1 (en) | 2011-04-04 | 2012-10-10 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Quantitative standard for mass spectrometry of proteins |
HUE057608T2 (hu) | 2011-05-24 | 2022-06-28 | BioNTech SE | Individualizált vakcinák a rák ellen |
SG11201405605VA (en) | 2012-03-12 | 2014-10-30 | Advaxis Inc | SUPPRESSOR CELL FUNCTION INHIBITION FOLLOWING <i>LISTERIA</i> VACCINE TREATMENT |
WO2013158611A1 (en) | 2012-04-16 | 2013-10-24 | Agenus Inc. | Methods and compositions for the treatment of glioblastomas |
AU2013289939B2 (en) | 2012-07-12 | 2018-08-09 | Persimmune, Inc. | Personalized cancer vaccines and adoptive immune cell therapies |
EP2893061B1 (en) | 2012-09-05 | 2019-05-22 | Arizona Board of Regents, a Body Corporate of the State of Arizona acting for and on behalf of Arizona State University | Methods for discovering therapeutic targets |
CA3169263A1 (en) | 2012-11-13 | 2014-05-22 | Astellas Pharma Inc. | Agents for treatment of claudin expressing cancer diseases |
CA2892391C (en) | 2012-11-28 | 2023-10-17 | Biontech Rna Pharmaceuticals Gmbh | Individualized vaccines for cancer |
US9695212B2 (en) | 2012-12-13 | 2017-07-04 | Aduro Biotech, Inc. | Compositions comprising cyclic purine dinucleotides having defined stereochemistries and methods for their preparation and use |
ES2939121T3 (es) | 2012-12-19 | 2023-04-19 | Max Planck Gesellschaft | Recipiente de reacción para preparación de muestras |
CN104955835B (zh) | 2012-12-27 | 2020-04-17 | 艾杜罗生物科技公司 | 促进抗原序列的李斯特菌表达的信号肽融合配偶体以及其制备和使用方法 |
DK3300745T3 (da) | 2013-02-15 | 2019-11-04 | Univ California | Kimærisk antigenreceptor og fremgangsmåder til anvendelse deraf |
KR102341899B1 (ko) | 2013-04-07 | 2021-12-21 | 더 브로드 인스티튜트, 인코퍼레이티드 | 개인맞춤화 신생물 백신을 위한 조성물 및 방법 |
WO2014180490A1 (en) | 2013-05-10 | 2014-11-13 | Biontech Ag | Predicting immunogenicity of t cell epitopes |
CU24377B1 (es) | 2013-05-18 | 2018-12-05 | Aduro Biotech Inc | Dinucléotidos de purina cíclicos y composiciones de los mismos útiles para inducir la producción de interferón de tipo i dependientes de sting |
EP3008204B1 (en) * | 2013-06-10 | 2024-03-13 | Iogenetics, LLC. | Mathematical processes for determination of peptidase cleavage |
EP3027203B1 (en) | 2013-07-30 | 2020-07-29 | BioNTech SE | Tumor antigens for determining cancer therapy |
WO2015014869A1 (en) | 2013-07-30 | 2015-02-05 | Biontech Ag | Tumor antigens for determining cancer therapy |
MX2016000750A (es) | 2013-08-02 | 2016-08-05 | Aduro Biotech Holdings Europe B V | Combinacion de agonistas de cd27 e inhibicion del punto de control inmunologico para estimulacion del sistema inmunologico. |
TWI777195B (zh) | 2013-08-05 | 2022-09-11 | 德商伊瑪提克斯生物科技有限公司 | 新穎肽類,細胞及其用於治療多種腫瘤的用途,其製造方法及包含其等之醫藥組成物(三) |
HUE040066T2 (hu) | 2013-08-19 | 2019-02-28 | Biontech Diagnostics Gmbh | Eljárások és felszerelések tumorok molekuláris szubtipizálásához |
EP2959021B1 (en) | 2013-08-19 | 2018-08-08 | BioNTech Diagnostics GmbH | Methods and kits for the molecular subtyping of tumors |
WO2015030585A2 (en) | 2013-08-27 | 2015-03-05 | Academisch Ziekenhuis Leiden H.O.D.N. Lumc | Methods for detecting post-translationally modified lysines in a polypeptide |
EP3041868A2 (en) | 2013-09-05 | 2016-07-13 | Aduro Biotech Holdings, Europe B.V. | Cd70-binding peptides and method, process and use relating thereto |
NL2011406C2 (en) | 2013-09-06 | 2015-03-10 | Bionovion Holding B V | Method for obtaining april-binding peptides, process for producing the peptides, april-binding peptides obtainable with said method/process and use of the april-binding peptides. |
CA2925047C (en) | 2013-09-26 | 2021-03-23 | Biontech Ag | Rna decorated particles |
WO2015058780A1 (en) | 2013-10-25 | 2015-04-30 | Biontech Ag | Method and kit for determining whether a subject shows an immune response |
EP3060679B1 (en) | 2013-10-25 | 2019-06-12 | BioNTech Diagnostics GmbH | Method and kit for determining whether a subject shows an immune response |
PE20171142A1 (es) | 2013-11-01 | 2017-08-10 | Pfizer | Vectores para expresion de antigenos asociados a prostata |
GB201319446D0 (en) | 2013-11-04 | 2013-12-18 | Immatics Biotechnologies Gmbh | Personalized immunotherapy against several neuronal and brain tumors |
WO2015085147A1 (en) | 2013-12-05 | 2015-06-11 | The Broad Institute Inc. | Polymorphic gene typing and somatic change detection using sequencing data |
JP7060324B2 (ja) * | 2013-12-20 | 2022-04-26 | ザ・ブロード・インスティテュート・インコーポレイテッド | ネオ抗原ワクチンによる併用療法 |
AU2014374020A1 (en) | 2014-01-02 | 2016-08-18 | Memorial Sloan Kettering Cancer Center | Determinants of cancer response to immunotherapy |
IL285403B2 (en) * | 2014-01-27 | 2023-10-01 | Molecular Templates Inc | Polypeptides that remove an epitope for MHC group I |
WO2015113576A1 (en) | 2014-01-29 | 2015-08-06 | Biontech Ag | Peptide mimotopes of claudin 18.2 and uses thereof |
US10654907B2 (en) | 2014-01-29 | 2020-05-19 | University Health Network | Methods and compositions for producing a cell expressing a T cell receptor |
WO2015126921A1 (en) | 2014-02-18 | 2015-08-27 | Advaxis, Inc. | Biomarker directed multi-target immunotherapy |
CA2940646A1 (en) | 2014-02-25 | 2015-09-03 | Advaxis, Inc. | Compositions and methods for the treatment of her2/neu over-expressing tumors |
CA2941405A1 (en) | 2014-03-05 | 2015-09-11 | Advaxis, Inc. | Methods and compositions for increasing a t-effector cell to regulatory t cell ratio |
US20150278441A1 (en) * | 2014-03-25 | 2015-10-01 | Nec Laboratories America, Inc. | High-order semi-Restricted Boltzmann Machines and Deep Models for accurate peptide-MHC binding prediction |
WO2015164121A1 (en) | 2014-04-24 | 2015-10-29 | Advaxis, Inc. | Recombinant listeria vaccine strains and methods of producing the same |
GB201408255D0 (en) | 2014-05-09 | 2014-06-25 | Immatics Biotechnologies Gmbh | Novel immunotherapy against several tumours of the blood, such as acute myeloid leukemia (AML) |
EP2944955A1 (en) | 2014-05-13 | 2015-11-18 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Benchmark for LC-MS systems |
WO2015172843A1 (en) | 2014-05-16 | 2015-11-19 | Biontech Diagnostics Gmbh | Methods and kits for the diagnosis of cancer |
GB201411037D0 (en) | 2014-06-20 | 2014-08-06 | Immatics Biotechnologies Gmbh | Novel immunotherapy against several tumors of the blood, in particular chronic lymphoid leukemai (CLL) |
US10000533B2 (en) | 2014-06-20 | 2018-06-19 | Immatics Biotechnologies Gmbh | Immunotherapy against several tumors of the blood, in particular chronic lymphoid leukemia (CLL) |
CN114984228A (zh) | 2014-07-18 | 2022-09-02 | 阿德瓦希斯股份有限公司 | 用于治疗前列腺癌的pd-1拮抗剂和基于李斯特菌的疫苗的组合 |
WO2016011320A1 (en) | 2014-07-18 | 2016-01-21 | Advaxis, Inc. | Bivalent listeria-based delivery system of heterologous antigens |
SG11201700090RA (en) | 2014-07-18 | 2017-02-27 | Advaxis Inc | Listeria-based immunogenic compositions for eliciting anti-tumor responses |
WO2016040682A1 (en) | 2014-09-10 | 2016-03-17 | Genentech, Inc. | Immunogenic mutant peptide screening platform |
CA2961179A1 (en) | 2014-09-14 | 2016-03-17 | Washington University | Personalized cancer vaccines and methods therefor |
SG11201702060VA (en) | 2014-09-15 | 2017-04-27 | Abvitro Inc | High-throughput nucleotide library sequencing |
JP7029294B2 (ja) | 2014-09-17 | 2022-03-03 | ザ・ジョンズ・ホプキンス・ユニバーシティー | 抗原特異的t細胞を同定、濃縮、及び/または増殖させるための試薬及び方法 |
EP3201322A4 (en) | 2014-10-03 | 2018-05-30 | Yale University | Innate immune system modification for anticancer therapy |
WO2016062323A1 (en) | 2014-10-20 | 2016-04-28 | Biontech Ag | Methods and compositions for diagnosis and treatment of cancer |
US20170335331A1 (en) | 2014-10-31 | 2017-11-23 | The Trustees Of The University Of Pennsylvania | Altering Gene Expression in CART Cells and Uses Thereof |
DE102014116335A1 (de) | 2014-11-10 | 2016-05-12 | Thyssenkrupp Ag | Verbundwerkstoff, Verbundwerkstoffprodukt, Verfahren zu deren Herstellung und Verwendungen dafür |
MA40737A (fr) | 2014-11-21 | 2017-07-04 | Memorial Sloan Kettering Cancer Center | Déterminants de la réponse d'un cancer à une immunothérapie par blocage de pd-1 |
EP3234130B1 (en) | 2014-12-19 | 2020-11-25 | The Broad Institute, Inc. | Methods for profiling the t-cell- receptor repertoire |
MA41218A (fr) | 2014-12-19 | 2017-10-24 | Advaxis Inc | Combinaison de vaccin à base de listeria comportant des anticorps anti-ox40 ou anti-gitr |
WO2016100975A1 (en) | 2014-12-19 | 2016-06-23 | Massachsetts Institute Ot Technology | Molecular biomarkers for cancer immunotherapy |
GB201501017D0 (en) | 2014-12-23 | 2015-03-04 | Immatics Biotechnologies Gmbh | Novel peptides and combination of peptides for use in immunotherapy against hepatocellular carcinoma (HCC) and other cancers |
ES2922398T3 (es) | 2015-01-08 | 2022-09-14 | BioNTech SE | Agentes agonistas de unión al receptor de TNF |
NL2014108B1 (en) | 2015-01-09 | 2016-09-30 | Aduro Biotech Holdings Europe B V | Altered april binding antibodies. |
US20160220652A1 (en) | 2015-02-03 | 2016-08-04 | Advaxis, Inc. | Methods of using recombinant listeria vaccine strains in disease immunotherapy |
WO2016126876A2 (en) | 2015-02-03 | 2016-08-11 | Advaxis, Inc. | Listeria-based adjuvants |
AU2016218072A1 (en) | 2015-02-09 | 2017-08-24 | Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. | Means and methods for minimizing swept and dead volumes in chromatographic applications |
WO2016128060A1 (en) | 2015-02-12 | 2016-08-18 | Biontech Ag | Predicting t cell epitopes useful for vaccination |
EP3259369B1 (en) | 2015-02-17 | 2022-04-27 | BioNTech Diagnostics GmbH | Methods and kits for the molecular subtyping of bladder cancer |
MA41644A (fr) | 2015-03-03 | 2018-01-09 | Advaxis Inc | Compositions à base de listeria comprenant un système d'expression de minigènes codant pour des peptides, et leurs procédés d'utilisation |
EP3267969A1 (en) | 2015-03-09 | 2018-01-17 | King's College London | Combination therapy with rar alpha agonists for enhancing th1 response |
WO2016145578A1 (en) | 2015-03-13 | 2016-09-22 | Syz Cell Therapy Co. | Methods of cancer treatment using activated t cells |
GB201504502D0 (en) | 2015-03-17 | 2015-04-29 | Immatics Biotechnologies Gmbh | Novel peptides and combination of peptides for use in immunotherapy against pancreatic cancer and other cancers |
WO2016154412A2 (en) | 2015-03-26 | 2016-09-29 | The Trustees Of The University Of Pennsylvania | Combination of a pd-1 antagonist and a listeria based vaccine for treating pancreatic cancer |
GB201505305D0 (en) | 2015-03-27 | 2015-05-13 | Immatics Biotechnologies Gmbh | Novel Peptides and combination of peptides for use in immunotherapy against various tumors |
GB201505585D0 (en) | 2015-03-31 | 2015-05-13 | Immatics Biotechnologies Gmbh | Novel peptides and combination of peptides and scaffolds for use in immunotherapy against renal cell carinoma (RCC) and other cancers |
WO2016155809A1 (en) | 2015-03-31 | 2016-10-06 | Biontech Rna Pharmaceuticals Gmbh | Lipid particle formulations for delivery of rna and water-soluble therapeutically effective compounds to a target cell |
BR112017022076A2 (pt) | 2015-04-13 | 2018-08-14 | Aduro Biotech, Inc. | fusões de mesotelina-variante iii de receptor de fator de crescimento epidérmico e métodos de uso das mesmas |
CN107980044A (zh) | 2015-04-13 | 2018-05-01 | 艾杜罗生物科技公司 | 用于治疗癌症的免疫原性融合蛋白 |
WO2016172624A1 (en) | 2015-04-22 | 2016-10-27 | Agenus Inc. | Methods for treating cancer |
GB201507030D0 (en) | 2015-04-24 | 2015-06-10 | Immatics Biotechnologies Gmbh | Immunotherapy against lung cancers, in particular NSCLC |
SG11201707920YA (en) | 2015-04-27 | 2017-11-29 | Cancer Research Tech Ltd | Method for treating cancer |
GB201507719D0 (en) | 2015-05-06 | 2015-06-17 | Immatics Biotechnologies Gmbh | Novel peptides and combination of peptides and scaffolds thereof for use in immunotherapy against colorectal carcinoma (CRC) and other cancers |
EP3292152A1 (en) | 2015-05-07 | 2018-03-14 | Agenus Inc. | Anti-ox40 antibodies and methods of use thereof |
WO2016180467A1 (en) | 2015-05-11 | 2016-11-17 | Biontech Cell & Gene Therapies Gmbh | Enhancing the effect of car-engineered t cells by means of nucleic acid vaccination |
US20180104284A1 (en) | 2015-05-13 | 2018-04-19 | Advaxis, Inc. | Immunogenic Listeria-Based Compositions Comprising Truncated Acta-Antigen Fusions And Methods Of Use Thereof |
SG10201912485PA (en) | 2015-05-13 | 2020-02-27 | Agenus Inc | Vaccines for treatment and prevention of cancer |
CR20200476A (es) | 2015-05-20 | 2020-12-02 | Dana Farber Cancer Inst Inc | ANTÍGENOS COMPARTIDOS (Divisional 2017-0584) |
US10293637B2 (en) | 2015-05-21 | 2019-05-21 | Burley Design Llc | Bicycle quick release cam lever with biased closure |
CN107847611A (zh) | 2015-05-26 | 2018-03-27 | 阿德瓦希斯公司 | 个性化的基于递送载体的免疫疗法及其用途 |
CN113603784A (zh) | 2015-05-29 | 2021-11-05 | 艾吉纳斯公司 | 抗-ctla-4抗体及其使用方法 |
GB201510771D0 (en) | 2015-06-19 | 2015-08-05 | Immatics Biotechnologies Gmbh | Novel peptides and combination of peptides for use in immunotherapy and methods for generating scaffolds for the use against pancreatic cancer |
CN108138099A (zh) | 2015-06-24 | 2018-06-08 | 阿德瓦希斯公司 | 用于个性化的基于递送载体的免疫疗法的制造装置和方法 |
GB201511191D0 (en) | 2015-06-25 | 2015-08-12 | Immatics Biotechnologies Gmbh | T-cell epitopes for the immunotherapy of myeloma |
GB201511546D0 (en) | 2015-07-01 | 2015-08-12 | Immatics Biotechnologies Gmbh | Novel peptides and combination of peptides for use in immunotherapy against ovarian cancer and other cancers |
GB201511792D0 (en) | 2015-07-06 | 2015-08-19 | Immatics Biotechnologies Gmbh | Novel peptides and combination of peptides for use in immunotherapy against esopageal cancer and other cancers |
EP3115369A1 (en) | 2015-07-09 | 2017-01-11 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Peptide purification using mixed-phase solid phase extraction material |
GB201512369D0 (en) | 2015-07-15 | 2015-08-19 | Immatics Biotechnologies Gmbh | Novel peptides and combination of peptides for use in immunotherapy against epithelial ovarian cancer and other cancers |
CN107848956A (zh) | 2015-07-29 | 2018-03-27 | 马克斯-普朗克科学促进学会 | 用于样品制备尤其是用于质谱分析的方式和方法 |
WO2017024006A1 (en) | 2015-08-03 | 2017-02-09 | The Johns Hopkins University | Personalized, allogeneic cell therapy of cancer |
GB201513921D0 (en) | 2015-08-05 | 2015-09-23 | Immatics Biotechnologies Gmbh | Novel peptides and combination of peptides for use in immunotherapy against prostate cancer and other cancers |
WO2017030956A1 (en) | 2015-08-14 | 2017-02-23 | Agenus Inc. | Method of inducing a t-cell response to phosphopeptides using nucleic acids encoding phosphopeptide mimetics |
US10130693B2 (en) | 2015-08-28 | 2018-11-20 | Immatics Biotechnologies Gmbh | Peptides, combination of peptides and scaffolds for use in immunotherapeutic treatment of various cancers |
GB201515321D0 (en) | 2015-08-28 | 2015-10-14 | Immatics Biotechnologies Gmbh | Novel peptides, combination of peptides and scaffolds for use in immunotherapeutic treatment of various cancers |
EP3344656A1 (en) | 2015-09-01 | 2018-07-11 | Agenus Inc. | Anti-pd-1 antibodies and methods of use thereof |
EP3936154A1 (en) | 2015-10-12 | 2022-01-12 | NantOmics, LLC | Compositions and methods for viral cancer neoepitopes |
US10546650B2 (en) * | 2015-10-23 | 2020-01-28 | Google Llc | Neural network for processing aptamer data |
CA3007473A1 (en) | 2015-12-14 | 2017-06-22 | Bellicum Pharmaceuticals, Inc. | Dual controls for therapeutic cell activation or elimination |
IL259931B2 (en) | 2015-12-16 | 2024-02-01 | Gritstone Bio Inc | Identification of neo-antigens, preparation, and use |
US10497089B2 (en) * | 2016-01-29 | 2019-12-03 | Fotonation Limited | Convolutional neural network |
US20190346442A1 (en) * | 2016-04-18 | 2019-11-14 | The Broad Institute, Inc. | Improved hla epitope prediction |
BR112019010565A2 (pt) | 2016-11-23 | 2019-09-17 | Gritstone Oncology Inc | aplicação viral de neoantígenos |
KR20180063481A (ko) | 2016-12-02 | 2018-06-12 | 주식회사 원소프트다임 | 체지방을 측정하는 클라우드 기반 휴대용 장치를 이용하여 헬스케어 정보를 제공하는 방법 및 이를 이용하는 장치 |
EP3600340A4 (en) * | 2017-03-31 | 2021-01-20 | ACT Genomics (IP) Co., Ltd. | CLASSIFICATION SYSTEM FOR CANCER-SPECIFIC IMMUNOGENIC EPITOPES |
US20210113673A1 (en) | 2017-04-19 | 2021-04-22 | Gritstone Oncology, Inc. | Neoantigen Identification, Manufacture, and Use |
JP2020523010A (ja) | 2017-06-09 | 2020-08-06 | グリットストーン オンコロジー インコーポレイテッド | 新生抗原の特定、製造、及び使用 |
AU2018328220A1 (en) | 2017-09-05 | 2020-04-23 | Gritstone Bio, Inc. | Neoantigen identification for T-cell therapy |
CN111465989B (zh) | 2017-10-10 | 2024-06-25 | 磨石生物公司 | 使用热点进行的新抗原鉴别 |
CN111630602A (zh) | 2017-11-22 | 2020-09-04 | 磨石肿瘤生物技术公司 | 减少新抗原的接合表位呈递 |
AU2019227813B2 (en) | 2018-02-27 | 2024-06-27 | Gritstone Bio, Inc. | Neoantigen identification with pan-allele models |
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Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103180730A (zh) * | 2010-05-14 | 2013-06-26 | 综合医院公司 | 鉴定肿瘤特异性新抗原的组合物和方法 |
Non-Patent Citations (1)
Title |
---|
期刊 2014年03月03日,Cancer Immunol Res. 2014 June ; 2(6): 522–529. CANCER IMMUNOL RES 2,6 CANCER IMMUNOL RES JUNE,2014 522-529 * |
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