MXPA02009157A - Nuevo sistema de expresion genetica inducible a base del receptor de ecdisona. - Google Patents
Nuevo sistema de expresion genetica inducible a base del receptor de ecdisona.Info
- Publication number
- MXPA02009157A MXPA02009157A MXPA02009157A MXPA02009157A MXPA02009157A MX PA02009157 A MXPA02009157 A MX PA02009157A MX PA02009157 A MXPA02009157 A MX PA02009157A MX PA02009157 A MXPA02009157 A MX PA02009157A MX PA02009157 A MXPA02009157 A MX PA02009157A
- Authority
- MX
- Mexico
- Prior art keywords
- gene expression
- expression system
- inducible gene
- ecdysone receptor
- relates
- Prior art date
Links
- 230000014509 gene expression Effects 0.000 title abstract 4
- 230000001939 inductive effect Effects 0.000 title abstract 2
- 108010057988 ecdysone receptor Proteins 0.000 title 1
- 241001465754 Metazoa Species 0.000 abstract 1
- 238000001415 gene therapy Methods 0.000 abstract 1
- 238000010353 genetic engineering Methods 0.000 abstract 1
- 238000012188 high-throughput screening assay Methods 0.000 abstract 1
- 238000011031 large-scale manufacturing process Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 230000009261 transgenic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1055—Protein x Protein interaction, e.g. two hybrid selection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70567—Nuclear receptors, e.g. retinoic acid receptor [RAR], RXR, nuclear orphan receptors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
- C07K14/721—Steroid/thyroid hormone superfamily, e.g. GR, EcR, androgen receptor, oestrogen receptor
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicinal Chemistry (AREA)
- Biotechnology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- High Energy & Nuclear Physics (AREA)
- Crystallography & Structural Chemistry (AREA)
- Plant Pathology (AREA)
- Bioinformatics & Computational Biology (AREA)
- Microbiology (AREA)
- Endocrinology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
La invencion se refiere al campo de la biotecnologia o ingenieria genetica. Especificamente, esta invencion se refiere al campo de la expresion genetica. Mas especificamente, esta invencion se refiere a un nuevo sistema de expresion genetica inducible y los metodos para modular la expresion genetica en una celula huesped para aplicaciones tales como terapia genetica, produccion a gran escala de proteinas y anticuerpos, analisis de seleccion de alto rendimiento en base a celulas, genomicos funcionales y regulacion de pruebas en plantas y animales transgenicos.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US19135500P | 2000-03-22 | 2000-03-22 | |
US26979901P | 2001-02-20 | 2001-02-20 | |
PCT/US2001/009050 WO2001070816A2 (en) | 2000-03-22 | 2001-03-21 | Ecdysone receptor-based inducible gene expression system |
Publications (1)
Publication Number | Publication Date |
---|---|
MXPA02009157A true MXPA02009157A (es) | 2004-04-05 |
Family
ID=26886975
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MXPA02009157A MXPA02009157A (es) | 2000-03-22 | 2001-03-21 | Nuevo sistema de expresion genetica inducible a base del receptor de ecdisona. |
Country Status (11)
Country | Link |
---|---|
US (1) | US7091038B2 (es) |
EP (1) | EP1266015B1 (es) |
JP (1) | JP5031967B2 (es) |
CN (1) | CN1304578C (es) |
AR (1) | AR028276A1 (es) |
AT (1) | ATE338135T1 (es) |
AU (2) | AU2001249315A1 (es) |
CA (1) | CA2404253C (es) |
DE (1) | DE60122685T2 (es) |
MX (1) | MXPA02009157A (es) |
WO (1) | WO2001070816A2 (es) |
Families Citing this family (73)
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US20040033600A1 (en) | 2001-03-21 | 2004-02-19 | Palli Subba Reddy | Ecdysone receptor-based inducible gene expression system |
US8105825B2 (en) * | 2000-10-03 | 2012-01-31 | Intrexon Corporation | Multiple inducible gene regulation system |
AU2002251724B2 (en) * | 2000-10-24 | 2007-06-21 | Syngenta Participations Ag | Control of gene expression in plants |
AU2002248500B2 (en) | 2001-02-20 | 2007-12-13 | Intrexon Corporation | Novel substitution mutant receptors and their use in a nuclear receptor-based inducible gene expression system |
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EP1373470B1 (en) | 2001-02-20 | 2013-04-24 | Intrexon Corporation | Novel substitution mutant receptors and their use in a nuclear receptor-based inducible gene expression system |
US7531326B2 (en) * | 2001-02-20 | 2009-05-12 | Intrexon Corporation | Chimeric retinoid X receptors and their use in a novel ecdysone receptor-based inducible gene expression system |
US7177763B2 (en) * | 2001-09-25 | 2007-02-13 | Werner Keber | Method and device for preventing unpermitted approach of airplanes to objects on the ground which are to be protected |
CA2820170C (en) | 2001-09-26 | 2016-07-05 | Intrexon Corporation | Whitefly ecdysone receptor nucleic acids, polypeptides, and uses thereof |
US7563879B2 (en) | 2001-09-26 | 2009-07-21 | Intrexon Corporation | Leafhopper ecdysone receptor nucleic acids, polypeptides, and uses thereof |
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JP4517347B2 (ja) * | 2004-07-02 | 2010-08-04 | 国立大学法人北海道大学 | 植物を用いたエストロゲン様物質の検出方法 |
US8097431B2 (en) * | 2004-08-04 | 2012-01-17 | University Of Utah Research Foundation | Methods and compositions for detecting steroids |
WO2007013929A1 (en) | 2005-07-22 | 2007-02-01 | Amgen Inc. | Aniline sulfonamide derivatives and their uses |
US8115059B1 (en) | 2005-07-22 | 2012-02-14 | University Of Kentucky Research Foundation | Gene expression modulation system for use in plants and method for modulating gene expression in plants |
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CN106589125B (zh) * | 2016-12-23 | 2020-04-14 | 江苏省农业科学院 | 抗绿盲蝽蜕皮激素受体蛋白的单克隆抗体及其用途 |
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JP2021503897A (ja) | 2017-11-22 | 2021-02-15 | グリットストーン オンコロジー インコーポレイテッド | 新生抗原のためのジャンクションエピトープ提示の低減 |
AU2019231652A1 (en) | 2018-03-06 | 2020-10-01 | Precigen, Inc. | Hepatitis B vaccines and uses of the same |
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WO2020206056A1 (en) | 2019-04-04 | 2020-10-08 | Greenvenus Llc | Peptides and methods of plant protection |
CN110592095A (zh) * | 2019-09-26 | 2019-12-20 | 浙江海洋大学 | 曼氏无针乌贼维甲酸x受体基因的克隆和表达 |
US20230111619A1 (en) * | 2019-11-19 | 2023-04-13 | Teknologian Tutkimuskeskus Vtt Oy | Non-viral transcription activation domains and methods and uses related thereto |
US20240024507A1 (en) | 2020-12-01 | 2024-01-25 | The Trustees Of The University Of Pennsylvania | Novel compositions with tissue-specific targeting motifs and compositions containing same |
MX2023012513A (es) | 2021-04-23 | 2023-12-15 | Univ Pennsylvania | Nuevas composiciones con motivos selectivos para el cerebro y composiciones que las contienen. |
WO2023056399A1 (en) | 2021-10-02 | 2023-04-06 | The Trustees Of The University Of Pennsylvania | Novel aav capsids and compositions containing same |
WO2023147304A1 (en) | 2022-01-25 | 2023-08-03 | The Trustees Of The University Of Pennsylvania | Aav capsids for improved heart transduction and detargeting of liver |
WO2024130070A2 (en) | 2022-12-17 | 2024-06-20 | The Trustees Of The University Of Pennsylvania | Recombinant aav capsids with cardiac- and skeletal muscle- specific targeting motifs and uses thereof |
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Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5283173A (en) | 1990-01-24 | 1994-02-01 | The Research Foundation Of State University Of New York | System to detect protein-protein interactions |
EP0522054A4 (en) | 1990-03-22 | 1993-02-10 | The Salk Institute For Biological Studies | Insect retinoid receptor compositions and methods |
JPH11500922A (ja) * | 1995-03-03 | 1999-01-26 | ノバルティス・アクチエンゲゼルシャフト | 化学リガンドの存在下での受容体媒介トランス活性化による植物における遺伝子発現の制御 |
CA2200423C (en) * | 1996-03-26 | 2006-12-19 | Sietse Mosselman | Novel estrogen receptor |
AU734051B2 (en) * | 1996-04-05 | 2001-05-31 | Salk Institute For Biological Studies, The | Hormone-mediated methods for modulating expression of exogenous genes in mammalian systems, and products related thereto |
US5919667A (en) * | 1996-06-20 | 1999-07-06 | The Salk Institute For Biological Studies | Modular assembly retroviral vectors and uses thereof |
AU738494B2 (en) * | 1997-07-10 | 2001-09-20 | Salk Institute For Biological Studies, The | Modified lepidopteran receptors and hybrid multifunctional proteins for use in regulation of transgene expression |
US6300488B1 (en) | 1997-07-10 | 2001-10-09 | The Salk Institute For Biological Studies | Modified lepidopteran receptors and hybrid multifunctional proteins for use in transcription and regulation of transgene expression |
AU9036198A (en) * | 1997-08-26 | 1999-03-16 | Ariad Gene Therapeutics, Inc. | Fusion proteins comprising a dimerization, trimerization or tetramerization domain and an additional heterologous transcription activation, transcription repression, dna binding or ligand binding domain |
US6333318B1 (en) * | 1998-05-14 | 2001-12-25 | The Salk Institute For Biological Studies | Formulations useful for modulating expression of exogenous genes in mammalian systems, and products related thereto |
US6258603B1 (en) * | 1998-06-17 | 2001-07-10 | Rohm And Haas Company | Ligands for modulating the expression of exogenous genes via an ecdysone receptor complex |
-
2001
- 2001-03-21 JP JP2001569016A patent/JP5031967B2/ja not_active Expired - Fee Related
- 2001-03-21 CN CNB018078443A patent/CN1304578C/zh not_active Expired - Fee Related
- 2001-03-21 AT AT01922524T patent/ATE338135T1/de active
- 2001-03-21 WO PCT/US2001/009050 patent/WO2001070816A2/en active IP Right Grant
- 2001-03-21 DE DE60122685T patent/DE60122685T2/de not_active Expired - Lifetime
- 2001-03-21 EP EP01922524A patent/EP1266015B1/en not_active Expired - Lifetime
- 2001-03-21 AU AU2001249315A patent/AU2001249315A1/en not_active Abandoned
- 2001-03-21 CA CA2404253A patent/CA2404253C/en not_active Expired - Lifetime
- 2001-03-21 MX MXPA02009157A patent/MXPA02009157A/es active IP Right Grant
- 2001-03-22 AR ARP010101339A patent/AR028276A1/es active IP Right Grant
- 2001-09-26 US US09/965,703 patent/US7091038B2/en not_active Expired - Lifetime
-
2007
- 2007-02-28 AU AU2007200882A patent/AU2007200882B2/en not_active Ceased
Also Published As
Publication number | Publication date |
---|---|
CA2404253C (en) | 2014-05-13 |
AU2007200882A1 (en) | 2007-03-22 |
DE60122685T2 (de) | 2007-08-23 |
AU2007200882B2 (en) | 2011-05-19 |
AU2001249315A1 (en) | 2001-10-03 |
ATE338135T1 (de) | 2006-09-15 |
AR028276A1 (es) | 2003-04-30 |
WO2001070816A2 (en) | 2001-09-27 |
US20020119521A1 (en) | 2002-08-29 |
US7091038B2 (en) | 2006-08-15 |
CA2404253A1 (en) | 2001-09-27 |
JP2003527852A (ja) | 2003-09-24 |
CN1304578C (zh) | 2007-03-14 |
EP1266015A2 (en) | 2002-12-18 |
EP1266015B1 (en) | 2006-08-30 |
WO2001070816A3 (en) | 2002-08-29 |
DE60122685D1 (de) | 2006-10-12 |
JP5031967B2 (ja) | 2012-09-26 |
CN1422334A (zh) | 2003-06-04 |
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