DE69524740D1 - Thymidin-kinase-mutanten - Google Patents

Thymidin-kinase-mutanten

Info

Publication number
DE69524740D1
DE69524740D1 DE69524740T DE69524740T DE69524740D1 DE 69524740 D1 DE69524740 D1 DE 69524740D1 DE 69524740 T DE69524740 T DE 69524740T DE 69524740 T DE69524740 T DE 69524740T DE 69524740 D1 DE69524740 D1 DE 69524740D1
Authority
DE
Germany
Prior art keywords
thymidine kinase
mutations
increases
amino acid
binding site
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69524740T
Other languages
English (en)
Other versions
DE69524740T2 (de
Inventor
A Loeb
E Black
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Washington
Original Assignee
University of Washington
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Washington filed Critical University of Washington
Application granted granted Critical
Publication of DE69524740D1 publication Critical patent/DE69524740D1/de
Publication of DE69524740T2 publication Critical patent/DE69524740T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
DE69524740T 1994-05-02 1995-05-02 Thymidin-kinase-mutanten Expired - Fee Related DE69524740T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US23759294A 1994-05-02 1994-05-02
PCT/US1995/005561 WO1995030007A1 (en) 1994-05-02 1995-05-02 Thymidine kinase mutants

Publications (2)

Publication Number Publication Date
DE69524740D1 true DE69524740D1 (de) 2002-01-31
DE69524740T2 DE69524740T2 (de) 2002-08-14

Family

ID=22894372

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69524740T Expired - Fee Related DE69524740T2 (de) 1994-05-02 1995-05-02 Thymidin-kinase-mutanten

Country Status (9)

Country Link
US (1) US5877010A (de)
EP (1) EP0758387B1 (de)
JP (1) JPH10503641A (de)
CN (1) CN1151186A (de)
AT (1) ATE211174T1 (de)
AU (1) AU2434195A (de)
CA (1) CA2189543A1 (de)
DE (1) DE69524740T2 (de)
WO (1) WO1995030007A1 (de)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6451571B1 (en) 1994-05-02 2002-09-17 University Of Washington Thymidine kinase mutants
FR2736931B1 (fr) * 1995-07-17 1997-09-19 Univ Paris Curie Sequences regulatrices issues du gene cd4 et a expression specifique dans les lymphocytes t matures
FR2751988B1 (fr) * 1996-08-01 1998-09-11 Rhone Poulenc Rorer Sa Nouveaux variants de la thymidine kinase, sequences d'acides nucleiques correspondantes et leur utilisation en therapie genique
US6207150B1 (en) 1996-02-09 2001-03-27 Aventis Pharma S.A. Variants of thymidine kinase, nucleic acids encoding them, and methods of using them
FR2744731B1 (fr) * 1996-02-09 1998-05-22 Rhone Poulenc Rorer Sa Nouveaux variants de la thymidine kinase, sequences d'acides nucleiques correspondantes et leur utilisation en therapie genique
FR2746016B1 (fr) * 1996-03-15 1998-04-17 Combinaisons d'enzymes pour la destruction de cellules proliferatives
GB9700154D0 (en) * 1997-01-07 1997-02-26 Primapharma Ltd Peptides
EP1025212B1 (de) 1997-10-14 2007-09-26 Darwin Molecular Corporation Thymidinkinase mutanten und fusionproteine mit thymidinkinase und guanylatekinase aktivitäten
EP1914304A1 (de) * 1998-10-14 2008-04-23 Darwin Molecular Corporation Thymidinkinasemutanten und Fusionsproteine mit Thymidinkinase- und Guanylatkinaseaktivität
US6709858B1 (en) * 1997-11-03 2004-03-23 The Arizona Board Of Regents On Behalf Of The University Of Arizona Hyperthermic inducible expression vectors for gene therapy and methods of use thereof
US7098191B2 (en) * 1997-11-03 2006-08-29 The Arizona Board Of Reagents Hyperthermic inducible expression vectors for gene therapy and methods of use thereof
US6461869B1 (en) * 1999-07-20 2002-10-08 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Purging leukemia cells from hematopoietic stem cells
GB0008966D0 (en) * 2000-04-13 2000-05-31 Imp College Innovations Ltd Vectors for gene therapy
AU783845B2 (en) * 2000-05-12 2005-12-15 Wolfgang Knecht Novel deoxynucleoside kinase enzyme variants
WO2003100045A1 (en) * 2002-05-23 2003-12-04 Wolfgang Knecht Plant thymidine kinases and their use
ES2320434T3 (es) * 2002-05-23 2009-05-22 Wolfgang Knecht Timidina quinasas vegetales y su uso.
US7815902B2 (en) * 2003-07-09 2010-10-19 Henry Ford Health System Methods and compositions for cancer therapy using a novel adenovirus
CN1871034B (zh) * 2003-07-09 2011-07-06 亨利福特保健系统公司 用新型腺病毒治疗癌症的方法和组合物
WO2005117993A2 (en) * 2004-06-04 2005-12-15 Genvec, Inc. Method of using adenoviral vectors with improved safety and efficacy for the treatment of cancer
GB0413702D0 (en) 2004-06-18 2004-07-21 Molmed Spa Thymidine kinase
WO2009012170A1 (en) * 2007-07-13 2009-01-22 California Institute Of Technology Targeting the absence: homozygous dna deletions as signposts for cancer therapy
AU2014236208B2 (en) * 2013-03-14 2018-07-19 Genvivo, Inc. Thymidine kinase diagnostic assay for gene therapy applications
CN104357466B (zh) * 2014-11-07 2017-04-19 重庆医科大学 一种单纯疱疹病毒胸苷激酶突变体及其制备方法和用途
WO2019020702A1 (en) 2017-07-26 2019-01-31 Medizinische Universität Wien THYMIDINE KINASE SUPERACTIVE FOR USE IN ANTICANCER THERAPY
WO2019108777A1 (en) 2017-11-29 2019-06-06 Research Development Foundation Elimination of proliferating cells from stem cell-derived grafts
KR102077648B1 (ko) 2017-12-28 2020-02-14 주식회사 바이오녹스 안전성 및 항암효과가 개선된 종양 용해 바이러스

Family Cites Families (23)

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Publication number Priority date Publication date Assignee Title
US5288641A (en) * 1984-06-04 1994-02-22 Arch Development Corporation Herpes Simplex virus as a vector
EP0274560A3 (de) * 1986-12-18 1990-03-21 Ajinomoto Co., Inc. Menschlicher, das hämatopoietische Zellwachstum aktivierender Faktor
WO1989009271A1 (en) * 1988-03-21 1989-10-05 Viagene, Inc. Recombinant retroviruses
EP0832980B1 (de) * 1989-01-23 2002-06-19 Chiron Corporation Rekombinanttherapien für Infektionen und hyperproliferative Störungen
WO1991002805A2 (en) * 1989-08-18 1991-03-07 Viagene, Inc. Recombinant retroviruses delivering vector constructs to target cells
GB8919607D0 (en) * 1989-08-30 1989-10-11 Wellcome Found Novel entities for cancer therapy
CA2039921A1 (en) * 1990-04-16 1991-10-17 Xandra O. Breakefield Transfer and expression of gene sequences into central nervous system cells using herpes simplex virus mutants with deletions in genes for viral replication
CA2051288C (en) * 1990-09-14 2002-02-05 Robert L. Martuza Viral targeted destruction of neoplastic cells
GB9104165D0 (en) * 1991-02-27 1991-04-17 Wellcome Found Novel entities for hiv therapy
US5358866A (en) * 1991-07-03 1994-10-25 The United States Of America As Represented By The Department Of Health And Human Services Cytosine deaminase negative selection system for gene transfer techniques and therapies
CA2113990A1 (en) * 1991-07-26 1993-02-18 Frederick L. Moolten Cancer therapy utilizing malignant cells
US5529774A (en) * 1991-08-13 1996-06-25 The Regents Of The University Of California In vivo transfer of the HSV-TK gene implanted retroviral producer cells
FR2683226B1 (fr) * 1991-10-30 1995-06-09 Univ Paris Curie Cellules piegees a l'egard d'antigenes provoquant le dysfonctionnement du systeme immunitaire, medicaments pour la prevention ou le traitement de maladies induites par ces dysfonctionnements.
CA2099247A1 (fr) * 1991-10-30 1993-05-01 David Klatzmann Cellules transformees pour la prevention ou le traitement de maladies induites par des virus, notamment retrovirus pathogenes
WO1993010218A1 (en) * 1991-11-14 1993-05-27 The United States Government As Represented By The Secretary Of The Department Of Health And Human Services Vectors including foreign genes and negative selective markers
JPH07506370A (ja) * 1992-05-01 1995-07-13 アメリカ合衆国 バイスタンダー作用による殺腫瘍療法
US5401835A (en) * 1992-07-31 1995-03-28 Chishti; Athar H. Human erythroid p55 nucleic acids
FR2699191B1 (fr) * 1992-12-16 1995-02-10 Univ Paris Curie Nouveaux vecteurs rétroviraux, lignées cellulaires les contenant, et leur utilisation dans le traitement des tumeurs.
WO1995006486A1 (en) * 1993-09-03 1995-03-09 Government Of The United States Of America, Secretary Department Of Health And Human Services Treatment of human tumors by genetic transformation of human tumor cells
GB9323008D0 (en) * 1993-11-05 1994-01-05 Connors Thomas Improvements relating to cancer therapy
FR2712602B1 (fr) * 1993-11-18 1996-02-09 Centre Nat Rech Scient Virus recombinants, préparation et utilisation en thérapie génique.
KR960703172A (ko) * 1993-11-18 1996-06-19 스티븐 제이. 멘토 조건적으로 치사적인 유전자를 활용하기 위한 조성물 및 방법(Compositions and methods for utilizing conditionally lethal genes)
FR2712603B1 (fr) * 1993-11-18 1996-02-09 Centre Nat Rech Scient Virus recombinants, préparation et utilisation en thérapie génique.

Also Published As

Publication number Publication date
CA2189543A1 (en) 1995-11-09
EP0758387A1 (de) 1997-02-19
AU2434195A (en) 1995-11-29
WO1995030007A1 (en) 1995-11-09
CN1151186A (zh) 1997-06-04
DE69524740T2 (de) 2002-08-14
EP0758387B1 (de) 2001-12-19
US5877010A (en) 1999-03-02
ATE211174T1 (de) 2002-01-15
JPH10503641A (ja) 1998-04-07

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Legal Events

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8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee