ATE338135T1 - Induziertes genexpressionssystem basierend auf ecdysonrezeptoren - Google Patents
Induziertes genexpressionssystem basierend auf ecdysonrezeptorenInfo
- Publication number
- ATE338135T1 ATE338135T1 AT01922524T AT01922524T ATE338135T1 AT E338135 T1 ATE338135 T1 AT E338135T1 AT 01922524 T AT01922524 T AT 01922524T AT 01922524 T AT01922524 T AT 01922524T AT E338135 T1 ATE338135 T1 AT E338135T1
- Authority
- AT
- Austria
- Prior art keywords
- ecdyson
- receptors
- gene expression
- system based
- expression system
- Prior art date
Links
- UPEZCKBFRMILAV-UHFFFAOYSA-N alpha-Ecdysone Natural products C1C(O)C(O)CC2(C)C(CCC3(C(C(C(O)CCC(C)(C)O)C)CCC33O)C)C3=CC(=O)C21 UPEZCKBFRMILAV-UHFFFAOYSA-N 0.000 title 1
- 230000014509 gene expression Effects 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1055—Protein x Protein interaction, e.g. two hybrid selection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70567—Nuclear receptors, e.g. retinoic acid receptor [RAR], RXR, nuclear orphan receptors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
- C07K14/721—Steroid/thyroid hormone superfamily, e.g. GR, EcR, androgen receptor, oestrogen receptor
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Toxicology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- Physics & Mathematics (AREA)
- Gastroenterology & Hepatology (AREA)
- General Engineering & Computer Science (AREA)
- Immunology (AREA)
- Cell Biology (AREA)
- High Energy & Nuclear Physics (AREA)
- Bioinformatics & Computational Biology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Endocrinology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US19135500P | 2000-03-22 | 2000-03-22 | |
| US26979901P | 2001-02-20 | 2001-02-20 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE338135T1 true ATE338135T1 (de) | 2006-09-15 |
Family
ID=26886975
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT01922524T ATE338135T1 (de) | 2000-03-22 | 2001-03-21 | Induziertes genexpressionssystem basierend auf ecdysonrezeptoren |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US7091038B2 (de) |
| EP (1) | EP1266015B1 (de) |
| JP (1) | JP5031967B2 (de) |
| CN (1) | CN1304578C (de) |
| AR (1) | AR028276A1 (de) |
| AT (1) | ATE338135T1 (de) |
| AU (2) | AU2001249315A1 (de) |
| CA (1) | CA2404253C (de) |
| DE (1) | DE60122685T2 (de) |
| MX (1) | MXPA02009157A (de) |
| WO (1) | WO2001070816A2 (de) |
Families Citing this family (80)
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|---|---|---|---|---|
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| ES2422303T3 (es) | 2001-02-20 | 2013-09-10 | Intrexon Corp | Receptores mutantes por sustitución novedosos y su uso en un sistema de expresión génica inducible basado en receptores nucleares |
| JP4994563B2 (ja) | 2001-02-20 | 2012-08-08 | イントレキソン コーポレーション | 新規置換突然変異体受容体および核受容体−ベースの誘導性遺伝子発現システムにおけるその使用 |
| ATE545705T1 (de) * | 2001-02-20 | 2012-03-15 | Intrexon Corp | Neues induzierbares genexpressionssystem auf ecdysonrezeptor/invertebraten-retinoid-x-rezept r-basis |
| AU2002247214B2 (en) | 2001-02-20 | 2008-04-03 | Intrexon Corporation | Chimeric retinoid X receptors and their use in a novel ecdysone receptor-based inducible gene expression system |
| DE10244149A1 (de) * | 2001-09-25 | 2003-04-30 | Werner Keber | Verfahren und Einrichtung zum Verhindern einer unzulässigen Flugannäherung von Flugzeugen an zu schützende Bodenobjeke |
| US7563879B2 (en) | 2001-09-26 | 2009-07-21 | Intrexon Corporation | Leafhopper ecdysone receptor nucleic acids, polypeptides, and uses thereof |
| WO2003027266A2 (en) | 2001-09-26 | 2003-04-03 | Rheogene Holdings, Inc. | Whitefly ecdysone receptor nucleic acids, polypeptides, and uses thereof |
| CA2475235C (en) * | 2002-02-05 | 2013-04-30 | Geymonat S.P.A. | Production process of recombinant placental growth factor |
| US9154906B2 (en) | 2002-03-28 | 2015-10-06 | Telecommunication Systems, Inc. | Area watcher for wireless network |
| US7375093B2 (en) * | 2002-07-05 | 2008-05-20 | Intrexon Corporation | Ketone ligands for modulating the expression of exogenous genes via an ecdysone receptor complex |
| JP4634931B2 (ja) * | 2003-02-07 | 2011-02-16 | クミアイ化学工業株式会社 | 脱皮ホルモン受容体及び当該受容体に対するリガンドのスクリーニング方法 |
| AU2011202682B2 (en) * | 2003-02-10 | 2013-11-28 | Intrexon Corporation | Diacylhydrazine ligands for modulating the expression of exogenous genes in mammalian systems via an ecdysone receptor complex |
| US7304161B2 (en) * | 2003-02-10 | 2007-12-04 | Intrexon Corporation | Diaclhydrazine ligands for modulating the expression of exogenous genes in mammalian systems via an ecdysone receptor complex |
| US7456315B2 (en) | 2003-02-28 | 2008-11-25 | Intrexon Corporation | Bioavailable diacylhydrazine ligands for modulating the expression of exogenous genes via an ecdysone receptor complex |
| WO2005022167A2 (en) * | 2003-08-29 | 2005-03-10 | The University Of North Carolina At Greensboro | Compounds that act to modulate insect growth and methods and systems for identifying such compounds |
| US8637237B2 (en) | 2003-08-29 | 2014-01-28 | The University Of North Carolina At Greensboro | Methods, compositions, and systems for the identification of species-specific or developmental stage-specific insecticides |
| US20050164210A1 (en) * | 2004-01-23 | 2005-07-28 | Vivek Mittal | Regulated polymerase III expression systems and related methods |
| US7935510B2 (en) * | 2004-04-30 | 2011-05-03 | Intrexon Corporation | Mutant receptors and their use in a nuclear receptor-based inducible gene expression system |
| JP4517347B2 (ja) * | 2004-07-02 | 2010-08-04 | 国立大学法人北海道大学 | 植物を用いたエストロゲン様物質の検出方法 |
| WO2006017813A2 (en) * | 2004-08-04 | 2006-02-16 | University Of Utah Research Foundation | Methods and compositions for detecting steroids |
| AU2006272922A1 (en) | 2005-07-22 | 2007-02-01 | Amgen Inc. | Aniline sulfonamide derivatives and their uses |
| US8115059B1 (en) | 2005-07-22 | 2012-02-14 | University Of Kentucky Research Foundation | Gene expression modulation system for use in plants and method for modulating gene expression in plants |
| WO2008073154A2 (en) | 2006-07-26 | 2008-06-19 | Intrexon Corporation | Methods and compositions for treating disease |
| CN101016518B (zh) * | 2006-09-12 | 2010-07-28 | 南方医科大学 | 一种生物杀虫剂筛选模型及其制备方法和应用 |
| WO2008137681A2 (en) | 2007-05-02 | 2008-11-13 | Intrexon Corporation | Pp1 ligands |
| CA2689137C (en) | 2007-05-29 | 2017-05-02 | Intrexon Corporation | Chiral diacylhydrazine ligands for modulating the expression of exogenous genes via an ecdysone receptor complex |
| US20090098055A1 (en) | 2007-08-23 | 2009-04-16 | Intrexon Corporation | Methods and Compositions for Diagnosing Disease |
| EP2183355B1 (de) | 2007-09-17 | 2016-01-27 | Rohm and Haas Company | Zusammensetzungen und verfahren zur modifizierung physiologischer reaktionen in pflanzen |
| JP2010540534A (ja) | 2007-09-28 | 2010-12-24 | イントレキソン コーポレーション | 生体治療分子の発現のための治療遺伝子スイッチ構築物およびバイオリアクター、ならびにその使用 |
| JP2010539993A (ja) * | 2007-10-08 | 2010-12-24 | イントレキソン コーポレーション | 遺伝子操作した樹状細胞および癌の治療のための使用 |
| WO2009114201A2 (en) * | 2008-03-14 | 2009-09-17 | Intrexon Corporation | Steroidal ligands and their use in gene switch modulation |
| BRPI0920679A2 (pt) | 2008-10-08 | 2022-05-17 | Intrexon Corp | Células construídas expressando múltiplos imunomoduladores e usos das mesmas |
| BRPI1009792A2 (pt) | 2009-03-05 | 2015-08-25 | Rohm & Haas | Sistema de expressão de gene para inibir controlavelmente o acúmulo em uma célula de planta, composição, e , métodos para produzir um planta transgênica e para modular a sensibilidade de etileno em uma planta. |
| MX362513B (es) | 2010-03-23 | 2019-01-22 | Intrexon Corp | Vectores que expresan de manera condicional proteinas terapeuticas, celulas hospedadoras que comprenden vectores, y usos de los mismos. |
| CN103154257A (zh) | 2010-09-26 | 2013-06-12 | 大玉企业有限公司 | 重组大分子生成方法 |
| SG10201600912SA (en) | 2011-03-04 | 2016-03-30 | Intrexon Corp | Vectors conditionally expressing protein |
| EP2699688A1 (de) | 2011-04-20 | 2014-02-26 | The Trustees Of The University Of Pennsylvania | Dosierpläne und zusammensetzungen zur aav-vermittelten passiven immunisierung von luftbürtigen krankheitserregern |
| WO2014144380A1 (en) | 2013-03-15 | 2014-09-18 | Intrexon Corporation | Boron-containing diacylhydrazines |
| US9719106B2 (en) | 2013-04-29 | 2017-08-01 | The Trustees Of The University Of Pennsylvania | Tissue preferential codon modified expression cassettes, vectors containing same, and uses thereof |
| WO2015009760A1 (en) | 2013-07-15 | 2015-01-22 | Donald Danforth Plant Science Center | Enhanced oil production and stress tolerance in plants |
| CN103555727B (zh) * | 2013-10-14 | 2015-06-10 | 中国水产科学研究院淡水渔业研究中心 | 一种中华绒螯蟹性早熟个体活体分子检测方法 |
| TW201625650A (zh) | 2014-09-17 | 2016-07-16 | 英翠克頌公司 | 含硼之二醯基肼化合物 |
| HK1248811A1 (zh) * | 2015-03-30 | 2018-10-19 | 英特瑞克斯顿股份有限公司 | 配体诱导型多肽耦合器系统 |
| EP3307310A2 (de) | 2015-05-13 | 2018-04-18 | The Trustees Of The University Of Pennsylvania | Aav-vermittelte expression von anti-influenza-antikörpern und verfahren zur verwendung davon |
| AU2016334401A1 (en) | 2015-10-10 | 2018-04-26 | Intrexon Corporation | Improved therapeutic control of proteolytically sensitive, destabilized forms of interleukin-12 |
| KR20180069081A (ko) | 2015-11-11 | 2018-06-22 | 인트렉손 코포레이션 | 심장 이상 및 기타 병리 이상의 치료를 위한 복수의 생물학적으로 활성화된 폴리펩티드를 단일 벡터로부터 발현하기 위한 조성물 및 방법 |
| CA3008641A1 (en) | 2015-12-16 | 2017-06-22 | Gritstone Oncology, Inc. | Neoantigen identification, manufacture, and use |
| JP7591342B2 (ja) | 2016-06-08 | 2024-11-28 | プレシゲン,インコーポレイテッド | Cd33特異的キメラ抗原受容体 |
| UY37343A (es) | 2016-07-25 | 2018-02-28 | Intrexon Corp | Control del fenotipo en plantas |
| WO2018089527A1 (en) | 2016-11-09 | 2018-05-17 | Intrexon Corporation | Frataxin expression constructs |
| CN106589125B (zh) * | 2016-12-23 | 2020-04-14 | 江苏省农业科学院 | 抗绿盲蝽蜕皮激素受体蛋白的单克隆抗体及其用途 |
| EP4382913A3 (de) | 2017-01-10 | 2024-08-14 | Precigen, Inc. | Modulation der expression von polypeptiden über neue genschalterexpressionssysteme |
| US11827906B2 (en) | 2017-02-28 | 2023-11-28 | The Trustees Of The University Of Pennsylvania | Adeno-associated virus (AAV) clade f vector and uses therefor |
| AU2018229293A1 (en) | 2017-02-28 | 2019-08-29 | Janssen Biotech, Inc. | Influenza vaccines based on AAV vectors |
| JOP20190200A1 (ar) | 2017-02-28 | 2019-08-27 | Univ Pennsylvania | تركيبات نافعة في معالجة ضمور العضل النخاعي |
| WO2018226897A1 (en) | 2017-06-07 | 2018-12-13 | Intrexon Corporation | Expression of novel cell tags |
| WO2019075112A1 (en) | 2017-10-10 | 2019-04-18 | Gritstone Oncology, Inc. | IDENTIFICATION OF NEO-ANTIGENS USING HOT POINTS |
| EP3714275A4 (de) | 2017-11-22 | 2021-10-27 | Gritstone bio, Inc. | Reduzierung der verbindungsepitopdarstellung für neoantigene |
| WO2019168984A1 (en) | 2018-02-27 | 2019-09-06 | Gritstone Oncology, Inc. | Neoantigen identification with pan-allele models |
| JP2021514666A (ja) | 2018-03-06 | 2021-06-17 | プレシゲン,インコーポレイテッド | B型肝炎ワクチンおよびその使用 |
| KR20250136930A (ko) | 2018-03-06 | 2025-09-16 | 프레시전 인코포레이티드 | 사람 파필로마바이러스 백신 및 이의 용도 |
| JP7575273B2 (ja) | 2018-04-16 | 2024-10-29 | ザ・トラステイーズ・オブ・ザ・ユニバーシテイ・オブ・ペンシルベニア | デュシェンヌ型筋ジストロフィーを治療するための組成物及び方法 |
| CN108913732B (zh) * | 2018-07-31 | 2022-02-08 | 华东理工大学 | 一种莫纳可林j异源生产的方法及应用 |
| CN109810993B (zh) * | 2019-03-25 | 2022-05-31 | 临沂大学 | 一种蝗虫β-D-葡萄糖苷水解酶基因及其应用 |
| WO2020206056A1 (en) | 2019-04-04 | 2020-10-08 | Greenvenus Llc | Peptides and methods of plant protection |
| CN110592095A (zh) * | 2019-09-26 | 2019-12-20 | 浙江海洋大学 | 曼氏无针乌贼维甲酸x受体基因的克隆和表达 |
| CA3161146A1 (en) * | 2019-11-19 | 2021-05-27 | Teknologian Tutkimuskeskus Vtt Oy | Non-viral transcription activation domains and methods and uses related thereto |
| MX2023006444A (es) | 2020-12-01 | 2023-08-10 | Univ Pennsylvania | Composiciones novedosas con motivos dirigidos a tejido específico y composiciones que los contienen. |
| AR125406A1 (es) | 2021-04-23 | 2023-07-12 | Univ Pennsylvania | Nuevas composiciones con motivos selectivos para el cerebro y composiciones que las contienen |
| WO2023056399A1 (en) | 2021-10-02 | 2023-04-06 | The Trustees Of The University Of Pennsylvania | Novel aav capsids and compositions containing same |
| EP4469584A1 (de) | 2022-01-25 | 2024-12-04 | The Trustees of The University of Pennsylvania | Aav-kapside zur verbesserten herztransduktion und detargeting der leber |
| WO2024130070A2 (en) | 2022-12-17 | 2024-06-20 | The Trustees Of The University Of Pennsylvania | Recombinant aav capsids with cardiac- and skeletal muscle- specific targeting motifs and uses thereof |
| EP4634394A2 (de) | 2022-12-17 | 2025-10-22 | The Trustees of The University of Pennsylvania | Rekombinante aav-mutantenvektoren mit herz- und skelettmuskelspezifischen zielmotiven und zusammensetzungen damit |
| WO2025007046A1 (en) | 2023-06-29 | 2025-01-02 | The Trustees Of The University Of Pennsylvania | Mutant aav with central nervous system targeting motifs and compositions containing same |
| WO2025102034A1 (en) | 2023-11-10 | 2025-05-15 | The Trustees Of The University Of Pennsylvania | Gene therapy for barth syndrome |
| WO2025106661A1 (en) | 2023-11-14 | 2025-05-22 | The Trustees Of The University Of Pennsylvania | Compositions with cardiac and skeletal musclespecific targeting motifs and uses thereof |
| CN119817530B (zh) * | 2025-02-25 | 2025-07-15 | 浙江省农业科学院 | 一种利用孤雌生殖辅助家蚕品种选育的方法 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5283173A (en) | 1990-01-24 | 1994-02-01 | The Research Foundation Of State University Of New York | System to detect protein-protein interactions |
| JPH11508121A (ja) | 1990-03-22 | 1999-07-21 | ザ ソーク インスティテュート フォア バイオロジカル スタディーズ | 昆虫レチノイドレセプター組成物および方法 |
| JPH11500922A (ja) * | 1995-03-03 | 1999-01-26 | ノバルティス・アクチエンゲゼルシャフト | 化学リガンドの存在下での受容体媒介トランス活性化による植物における遺伝子発現の制御 |
| CA2200423C (en) * | 1996-03-26 | 2006-12-19 | Sietse Mosselman | Novel estrogen receptor |
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| WO1999002683A1 (en) * | 1997-07-10 | 1999-01-21 | The Salk Institute For Biological Studies | Modified lepidopteran receptors and hybrid multifunctional proteins for use in regulation of transgene expression |
| CA2300376A1 (en) * | 1997-08-26 | 1999-03-04 | Ariad Gene Therapeutics, Inc. | Fusion proteins comprising a dimerization, trimerization or tetramerization domain and an additional heterologous transcription activation, transcription repression, dna binding or ligand binding domain |
| US6333318B1 (en) * | 1998-05-14 | 2001-12-25 | The Salk Institute For Biological Studies | Formulations useful for modulating expression of exogenous genes in mammalian systems, and products related thereto |
| US6258603B1 (en) * | 1998-06-17 | 2001-07-10 | Rohm And Haas Company | Ligands for modulating the expression of exogenous genes via an ecdysone receptor complex |
-
2001
- 2001-03-21 JP JP2001569016A patent/JP5031967B2/ja not_active Expired - Fee Related
- 2001-03-21 WO PCT/US2001/009050 patent/WO2001070816A2/en not_active Ceased
- 2001-03-21 AT AT01922524T patent/ATE338135T1/de active
- 2001-03-21 DE DE60122685T patent/DE60122685T2/de not_active Expired - Lifetime
- 2001-03-21 AU AU2001249315A patent/AU2001249315A1/en not_active Abandoned
- 2001-03-21 EP EP01922524A patent/EP1266015B1/de not_active Expired - Lifetime
- 2001-03-21 CA CA2404253A patent/CA2404253C/en not_active Expired - Lifetime
- 2001-03-21 CN CNB018078443A patent/CN1304578C/zh not_active Expired - Fee Related
- 2001-03-21 MX MXPA02009157A patent/MXPA02009157A/es active IP Right Grant
- 2001-03-22 AR ARP010101339A patent/AR028276A1/es active IP Right Grant
- 2001-09-26 US US09/965,703 patent/US7091038B2/en not_active Expired - Lifetime
-
2007
- 2007-02-28 AU AU2007200882A patent/AU2007200882B2/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| AU2001249315A1 (en) | 2001-10-03 |
| US20020119521A1 (en) | 2002-08-29 |
| AU2007200882A1 (en) | 2007-03-22 |
| CN1422334A (zh) | 2003-06-04 |
| JP5031967B2 (ja) | 2012-09-26 |
| WO2001070816A2 (en) | 2001-09-27 |
| AU2007200882B2 (en) | 2011-05-19 |
| DE60122685D1 (de) | 2006-10-12 |
| EP1266015B1 (de) | 2006-08-30 |
| US7091038B2 (en) | 2006-08-15 |
| MXPA02009157A (es) | 2004-04-05 |
| AR028276A1 (es) | 2003-04-30 |
| CN1304578C (zh) | 2007-03-14 |
| CA2404253C (en) | 2014-05-13 |
| CA2404253A1 (en) | 2001-09-27 |
| DE60122685T2 (de) | 2007-08-23 |
| JP2003527852A (ja) | 2003-09-24 |
| EP1266015A2 (de) | 2002-12-18 |
| WO2001070816A3 (en) | 2002-08-29 |
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