ATE545705T1 - Neues induzierbares genexpressionssystem auf ecdysonrezeptor/invertebraten-retinoid-x-rezept r-basis - Google Patents

Neues induzierbares genexpressionssystem auf ecdysonrezeptor/invertebraten-retinoid-x-rezept r-basis

Info

Publication number
ATE545705T1
ATE545705T1 AT02714955T AT02714955T ATE545705T1 AT E545705 T1 ATE545705 T1 AT E545705T1 AT 02714955 T AT02714955 T AT 02714955T AT 02714955 T AT02714955 T AT 02714955T AT E545705 T1 ATE545705 T1 AT E545705T1
Authority
AT
Austria
Prior art keywords
gene expression
expression system
recipe
system based
inducible gene
Prior art date
Application number
AT02714955T
Other languages
English (en)
Inventor
Subba Palli
Marianna Zinovjevna Kapitskaya
Original Assignee
Intrexon Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26953897&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE545705(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Intrexon Corp filed Critical Intrexon Corp
Application granted granted Critical
Publication of ATE545705T1 publication Critical patent/ATE545705T1/de

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
    • C07K14/721—Steroid/thyroid hormone superfamily, e.g. GR, EcR, androgen receptor, oestrogen receptor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70567—Nuclear receptors, e.g. retinoic acid receptor [RAR], RXR, nuclear orphan receptors

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Wood Science & Technology (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
AT02714955T 2001-02-20 2002-02-20 Neues induzierbares genexpressionssystem auf ecdysonrezeptor/invertebraten-retinoid-x-rezept r-basis ATE545705T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US26979901P 2001-02-20 2001-02-20
US29481401P 2001-05-31 2001-05-31
PCT/US2002/005235 WO2002066613A2 (en) 2001-02-20 2002-02-20 Novel ecdysone receptor/invertebrate retinoid x receptor-based inducible gene expression system

Publications (1)

Publication Number Publication Date
ATE545705T1 true ATE545705T1 (de) 2012-03-15

Family

ID=26953897

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02714955T ATE545705T1 (de) 2001-02-20 2002-02-20 Neues induzierbares genexpressionssystem auf ecdysonrezeptor/invertebraten-retinoid-x-rezept r-basis

Country Status (11)

Country Link
US (2) US9493540B2 (de)
EP (1) EP1456346B1 (de)
JP (3) JP4955904B2 (de)
AT (1) ATE545705T1 (de)
AU (2) AU2002247184B2 (de)
CA (1) CA2441444C (de)
DK (1) DK1456346T3 (de)
ES (1) ES2385598T3 (de)
MX (1) MXPA03007493A (de)
PT (1) PT1456346E (de)
WO (1) WO2002066613A2 (de)

Families Citing this family (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040033600A1 (en) 2001-03-21 2004-02-19 Palli Subba Reddy Ecdysone receptor-based inducible gene expression system
US8105825B2 (en) 2000-10-03 2012-01-31 Intrexon Corporation Multiple inducible gene regulation system
WO2002066612A2 (en) 2001-02-20 2002-08-29 Rheogene, Inc. Novel substitution mutant receptors and their use in a nuclear receptor-based inducible gene expression system
CA2438119C (en) 2001-02-20 2014-12-16 Rheogene Holdings, Inc. Chimeric retinoid x receptors and their use in a novel ecdysone receptor-based inducible gene expression system
ES2390070T3 (es) 2001-02-20 2012-11-06 Intrexon Corporation Nuevos receptores mutantes de sustitución y su uso en un sistema de expresión génica inducible basado en receptores nucleares
ATE545705T1 (de) 2001-02-20 2012-03-15 Intrexon Corp Neues induzierbares genexpressionssystem auf ecdysonrezeptor/invertebraten-retinoid-x-rezept r-basis
JP2005532781A (ja) * 2001-09-26 2005-11-04 レオジーン・ホールディングス，インコーポレーテッド ヨコバイエクジソン受容体核酸、ポリペプチド、およびそれらの使用
JP2005507247A (ja) 2001-09-26 2005-03-17 レオジーン・ホールディングス，インコーポレーテッド コナジラミエクジソン受容体核酸、ポリペプチド、およびそれらの使用
US7304161B2 (en) 2003-02-10 2007-12-04 Intrexon Corporation Diaclhydrazine ligands for modulating the expression of exogenous genes in mammalian systems via an ecdysone receptor complex
US7456315B2 (en) 2003-02-28 2008-11-25 Intrexon Corporation Bioavailable diacylhydrazine ligands for modulating the expression of exogenous genes via an ecdysone receptor complex
US7935510B2 (en) * 2004-04-30 2011-05-03 Intrexon Corporation Mutant receptors and their use in a nuclear receptor-based inducible gene expression system
RU2468820C2 (ru) 2006-07-26 2012-12-10 Интрексон Корпорейшн Способы и композиции для лечения заболевания
JP5881291B2 (ja) 2007-05-29 2016-03-09 イントレキソン コーポレーション エクジソン受容体複合体を通して外因性遺伝子の発現を調節するためのキラルジアシルヒドラジンリガンド
CN101835908A (zh) * 2007-08-23 2010-09-15 英特瑞克斯顿股份有限公司 诊断疾病的方法和组合物
JP2010540534A (ja) 2007-09-28 2010-12-24 イントレキソン コーポレーション 生体治療分子の発現のための治療遺伝子スイッチ構築物およびバイオリアクター、ならびにその使用
ES2636460T3 (es) 2007-10-08 2017-10-05 Intrexon Corporation Células dendríticas modificadas por ingeniería y usos para el tratamiento del cáncer
AU2009223721B2 (en) 2008-03-14 2015-01-29 Intrexon Corporation Steroidal ligands and their use in gene switch modulation
JP5272898B2 (ja) 2009-05-29 2013-08-28 ソニー株式会社 信号処理装置、信号処理方法、および受信システム
KR20180108886A (ko) 2010-03-23 2018-10-04 인트렉손 코포레이션 치료적 단백질을 조건부로 발현하는 벡터，상기 벡터를 포함하는 숙주 세포 및 이의 용도
US9402919B2 (en) 2011-03-04 2016-08-02 Intrexon Corporation Vectors conditionally expressing protein
US20140031418A1 (en) 2011-04-20 2014-01-30 The Trustees Of The University Of Pennsylvania Regimens and Compositions for AAV-Mediated Passive Immunization of Airborne Pathogens
SG11201506875YA (en) 2013-03-15 2015-09-29 Intrexon Corp Boron-containing diacylhydrazines
US9719106B2 (en) 2013-04-29 2017-08-01 The Trustees Of The University Of Pennsylvania Tissue preferential codon modified expression cassettes, vectors containing same, and uses thereof
ES3013744T3 (en) 2013-09-18 2025-04-15 Kymab Ltd Methods, cells and organisms
TW201625650A (zh) 2014-09-17 2016-07-16 英翠克頌公司 含硼之二醯基肼化合物
US11535665B2 (en) 2015-05-13 2022-12-27 The Trustees Of The University Of Pennsylvania AAV-mediated expression of anti-influenza antibodies and methods of use thereof
EP3347373A1 (de) 2015-10-10 2018-07-18 Intrexon Corporation Verbesserte therapeutische kontrolle von proteolytisch sensitiven destabilisierten formen von interleukin-12
CA3004742A1 (en) 2015-11-11 2017-05-18 Intrexon Corporation Compositions and methods for expression of multiple biologically active polypeptides from a single vector for treatment of cardiac conditions and other pathologies
WO2017214333A1 (en) 2016-06-08 2017-12-14 Intrexon Corporation Cd33 specific chimeric antigen receptors
UY37343A (es) 2016-07-25 2018-02-28 Intrexon Corp Control del fenotipo en plantas
CN110139933B (zh) 2016-11-09 2024-03-08 英特瑞克斯顿股份有限公司 共济蛋白表达构建体
WO2018132494A1 (en) 2017-01-10 2018-07-19 Intrexon Corporation Modulating expression of polypeptides via new gene switch expression systems
JOP20190200A1 (ar) 2017-02-28 2019-08-27 Univ Pennsylvania تركيبات نافعة في معالجة ضمور العضل النخاعي
KR20190135000A (ko) 2017-02-28 2019-12-05 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 Aav 벡터를 기반으로 하는 인플루엔자 백신
SMT202400080T1 (it) 2017-02-28 2024-05-14 Univ Pennsylvania Vettore di clade f di virus adenoassociato (aav) e relativi usi
IL270990B2 (en) 2017-06-07 2024-02-01 Precigen Inc Expression of new cell markers
WO2019173465A1 (en) 2018-03-06 2019-09-12 Intrexon Corporation Human papillomavirus vaccines and uses of the same
IL277128B2 (en) 2018-03-06 2025-11-01 Precigen Inc Hepatitis b vaccines and uses of the same
US12460226B2 (en) 2018-04-16 2025-11-04 The Trustees Of The University Of Pennsylvania Compositions and methods for treating duchenne muscular dystrophy
WO2020206056A1 (en) 2019-04-04 2020-10-08 Greenvenus Llc Peptides and methods of plant protection
IL303236A (en) 2020-12-01 2023-07-01 Univ Pennsylvania Novel compositions with tissue-specific targeting motifs and compositions containing same
CA3216004A1 (en) 2021-04-23 2022-10-27 The Trustees Of The University Of Pennsylvania Novel compositions with brain-specific targeting motifs and compositions containing same
WO2023056399A1 (en) 2021-10-02 2023-04-06 The Trustees Of The University Of Pennsylvania Novel aav capsids and compositions containing same
KR20240137067A (ko) 2022-01-25 2024-09-19 더 트러스티스 오브 더 유니버시티 오브 펜실베니아 개선된 심장 형질도입 및 간의 탈표적화를 위한 aav 캡시드
WO2024130070A2 (en) 2022-12-17 2024-06-20 The Trustees Of The University Of Pennsylvania Recombinant aav capsids with cardiac- and skeletal muscle- specific targeting motifs and uses thereof
TW202440939A (zh) 2022-12-17 2024-10-16 賓州大學委員會 具心臟及骨骼肌特異性靶向模體的重組aav突變載體及含有其之組成物
WO2025007046A1 (en) 2023-06-29 2025-01-02 The Trustees Of The University Of Pennsylvania Mutant aav with central nervous system targeting motifs and compositions containing same
WO2025102034A1 (en) 2023-11-10 2025-05-15 The Trustees Of The University Of Pennsylvania Gene therapy for barth syndrome
WO2025106661A1 (en) 2023-11-14 2025-05-22 The Trustees Of The University Of Pennsylvania Compositions with cardiac and skeletal musclespecific targeting motifs and uses thereof

Family Cites Families (90)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4631211A (en) 1985-03-25 1986-12-23 Scripps Clinic & Research Foundation Means for sequential solid phase organic synthesis and methods using the same
US5424333A (en) 1985-10-21 1995-06-13 Rohm And Haas Company Anthelmintic N'-substituted-N,N'-disubstitutedhydrazines
US5117057A (en) 1985-10-21 1992-05-26 Rohm And Haas Company Insecticidal N' substituted-N-N'-disubstituted-hydrazines
US4985461A (en) 1985-10-21 1991-01-15 Rohm And Haas Company Insecticidal N'-substituted-N,N'-diacylhydrazines
FR2593630B1 (fr) 1986-01-27 1988-03-18 Maurice Francois Ecran d'affichage a matrice active a resistance de drain et procedes de fabrication de cet ecran
US4859609A (en) 1986-04-30 1989-08-22 Genentech, Inc. Novel receptors for efficient determination of ligands and their antagonists or agonists
US5225443A (en) 1986-05-01 1993-07-06 Rohm And Haas Company Insecticidal N'-substituted-N'-substituted N,N'-diacylhydrazines
US5071773A (en) 1986-10-24 1991-12-10 The Salk Institute For Biological Studies Hormone receptor-related bioassays
US5171671A (en) 1987-12-02 1992-12-15 The Salk Institute For Biological Studies Retinoic acid receptor composition
US4981784A (en) 1987-12-02 1991-01-01 The Salk Institute For Biological Studies Retinoic acid receptor method
US5429952A (en) 1988-02-02 1995-07-04 Biocode, Inc. Marking of products to establish identity and source
US5010175A (en) 1988-05-02 1991-04-23 The Regents Of The University Of California General method for producing and selecting peptides with specific properties
DE68927438T2 (de) 1988-06-13 1997-03-20 American Biogenetic Sciences Verfahren zur herstellung monoklonaler antikörper mit hilfe eines keimfreien tieres
US4954655A (en) 1989-03-31 1990-09-04 Rohm And Haas Company Preparation of alkylhydrazines
US5283173A (en) 1990-01-24 1994-02-01 The Research Foundation Of State University Of New York System to detect protein-protein interactions
EP0999271A3 (de) 1990-02-09 2003-04-02 The Salk Institute For Biological Studies Retinoid-rezeptor-Zusammensetzungen und Verfahren
WO1991013167A1 (en) 1990-02-26 1991-09-05 The Board Of Trustees Of The Leland Stanford Junior University Identification and expression of insect steroid receptor dna sequences
WO1991014695A1 (en) 1990-03-22 1991-10-03 The Salk Institute For Biological Studies Insect retinoid receptor compositions and methods
US5688691A (en) 1990-03-22 1997-11-18 The Salk Institute For Biological Studies Insect retinoid-like receptor compositions and methods
US7119077B1 (en) 1990-03-22 2006-10-10 The Salk Institute For Biological Studies Multimeric forms of members of the steroid/thyroid superfamily of receptors with the ultraspiracle receptor
US5264618A (en) 1990-04-19 1993-11-23 Vical, Inc. Cationic lipids for intracellular delivery of biologically active molecules
CA2043775A1 (en) 1990-06-14 1991-12-15 Dat P. Le Dibenzoylakylcyanohydrazines
US5139749A (en) 1990-06-22 1992-08-18 Tas, Inc. Fluidized calcining process
IL100643A (en) 1991-01-25 1996-10-31 Nippon Kayaku Kk History of hydrazine and pesticides containing these histories as an active ingredient
US5668175A (en) 1991-08-23 1997-09-16 The Salk Institute For Biological Studies Use of selective ligands for treatment of disease states responsive to steroid or steroid-like retinoids
EP0600028B1 (de) 1991-08-23 2001-11-07 The Salk Institute For Biological Studies Verwendung von selektiven liganden zur behandlung von hormonansprechenden krankheitzuständen
ATE215601T1 (de) 1991-09-17 2002-04-15 Salk Inst For Biological Studi Rezeptoren der steroid/thyroid superfamilie von rezeptoren
JPH07503609A (ja) 1991-12-06 1995-04-20 ザ　ソールク　インスチチュート　フォア　バイオロジカル　スタディズ リセプターのステロイド／甲状腺スーパーファミリーのメンバーの多量体型
JPH06510206A (ja) 1992-01-24 1994-11-17 アンスティテュー・ナシオナル・ドゥ・ラ・サンテ・エ・ドゥ・ラ・ルシェルシュ・メディカル 新規ヘテロダイマー核レセプタータンパク質、それをコードする遺伝子、およびその使用
US6013836A (en) 1992-02-28 2000-01-11 Rohm And Haas Company Insecticidal N'-substituted-N,N'-disubstitutedhydrazines
US5530028A (en) 1992-11-23 1996-06-25 Rohm And Haas Company Insecticidal N'-substituted-N,N'-diacylhydrazines
NZ267843A (en) 1993-05-27 1997-10-24 Selectide Corp Libraries of synthetic test compound attached to separate phase synthesis supports
AU1173995A (en) 1993-11-10 1995-05-29 Arch Development Corporation Ubiquitous nuclear receptor: compositions and methods
FR2714830B1 (fr) 1994-01-10 1996-03-22 Rhone Poulenc Rorer Sa Composition contenant des acides nucléiques, préparation et utilisations.
FR2715847B1 (fr) 1994-02-08 1996-04-12 Rhone Poulenc Rorer Sa Composition contenant des acides nucléiques, préparation et utilisations.
FR2727679B1 (fr) 1994-12-05 1997-01-03 Rhone Poulenc Rorer Sa Nouveaux agents de transfection et leurs applications pharmaceutiques
US6326166B1 (en) 1995-12-29 2001-12-04 Massachusetts Institute Of Technology Chimeric DNA-binding proteins
CA2210248A1 (en) 1995-01-13 1996-07-18 Ronald M. Evans Allosteric control of nuclear hormone receptors
FR2730637B1 (fr) 1995-02-17 1997-03-28 Rhone Poulenc Rorer Sa Composition pharmaceutique contenant des acides nucleiques, et ses utilisations
ES2237764T3 (es) 1995-03-03 2005-08-01 Syngenta Participations Ag Control de la expresion genica en plantas por transactivacion mediada por un receptor en presencia de un ligando quimico.
NZ308162A (en) 1995-05-26 2000-02-28 Zeneca Pharma Sa Insect steroid (ecdysone) receptors and such nucleic acids in screening methods and gene switches
US5939442A (en) 1995-06-07 1999-08-17 The Salk Institute For Biological Studies Modulations of peroxisome proliferator activated receptor-γ, and methods for the use thereof
US6266622B1 (en) 1995-12-13 2001-07-24 Regents Of The University Of California Nuclear receptor ligands and ligand binding domains
GB9606126D0 (en) 1996-03-22 1996-05-22 British Biotech Pharm Biosensors
CA2200423C (en) 1996-03-26 2006-12-19 Sietse Mosselman Novel estrogen receptor
CN1215432A (zh) 1996-04-05 1999-04-28 索尔克生物学研究所 调节外源性基因在哺乳动物系统中表达的激素介导的方法及其相关产物
US6723531B2 (en) 1996-04-05 2004-04-20 The Salk Institute For Biological Studies Method for modulating expression of exogenous genes in mammalian systems, and products related thereto
US6610828B1 (en) 1996-05-24 2003-08-26 Syngenta Limited Heliothis ecdysone receptor
US6025483A (en) 1996-06-05 2000-02-15 The Regents Of The University Of California Maize and cauliflower apetalai gene products and nucleic acid molecules encoding same
US5919667A (en) 1996-06-20 1999-07-06 The Salk Institute For Biological Studies Modular assembly retroviral vectors and uses thereof
AU6007798A (en) 1997-02-14 1998-09-08 New Zealand Pastoral Agriculture Research Institute Limited Insect ecdysteroid receptors
CA2296093A1 (en) 1997-07-10 1999-01-21 The Salk Institute For Biological Studies Modified lepidopteran receptors and hybrid multifunctional proteins for use in regulation of transgene expression
US6300488B1 (en) 1997-07-10 2001-10-09 The Salk Institute For Biological Studies Modified lepidopteran receptors and hybrid multifunctional proteins for use in transcription and regulation of transgene expression
JP2003524368A (ja) 1997-08-26 2003-08-19 アリアド ジーン セラピューティクス インコーポレイテッド ニ量化ドメイン、三量化ドメインまたは四量化ドメインおよび補足的非相同転写活性化ドメイン、転写抑制ドメイン、ｄｎａ結合ドメインまたはリガンド結合ドメインを含む融合蛋白
US7101681B1 (en) 1997-11-21 2006-09-05 Amgen, Inc. Nuclear hormone receptor drug screens
US6756491B2 (en) 1998-01-09 2004-06-29 The Salk Institute For Biological Studies Steroid-activated nuclear receptors and uses therefor
AUPP135698A0 (en) 1998-01-15 1998-02-05 Commonwealth Scientific And Industrial Research Organisation Insectical modalities
US6410245B1 (en) 1998-04-01 2002-06-25 Affymax, Inc. Compositions and methods for detecting ligand-dependent nuclear receptor and coactivator interactions
CA2327400A1 (en) 1998-04-06 1999-10-14 Bunsen Rush Laboratories, Inc. Directed evolution biosensors
US6333318B1 (en) 1998-05-14 2001-12-25 The Salk Institute For Biological Studies Formulations useful for modulating expression of exogenous genes in mammalian systems, and products related thereto
US6258603B1 (en) 1998-06-17 2001-07-10 Rohm And Haas Company Ligands for modulating the expression of exogenous genes via an ecdysone receptor complex
US6117639A (en) 1998-08-31 2000-09-12 Vertex Pharmaceuticals Incorporated Fusion proteins, DNA molecules, vectors, and host cells useful for measuring protease activity
MXPA01002529A (es) 1998-09-10 2003-03-10 Pioneer Hi Bred Int Receptores de ecdisona y metodos para su uso.
AU6501499A (en) 1998-09-29 2000-04-17 Johns Hopkins University, The Inducible genetic suppression of cellular excitability
US5989863A (en) 1998-10-14 1999-11-23 Incyte Pharmaceuticals, Inc. Human ankyrin family protein
WO2000071743A1 (fr) 1999-05-25 2000-11-30 Eisai Co., Ltd. Methode bihybride dans une cellule de mammifere
US6439706B1 (en) 1999-05-25 2002-08-27 Silverbrook Research Pty Ltd. Printer cartridge with binder
EP1203022A4 (de) 1999-07-01 2004-09-08 Commw Scient Ind Res Org Neue genetische sequenzen, die für steroid- und juvenil-hormonrezeptor-polypeptide kodieren und ihre verwendungen
US7057015B1 (en) 1999-10-20 2006-06-06 The Salk Institute For Biological Studies Hormone receptor functional dimers and methods of their use
WO2001062780A1 (en) * 2000-02-24 2001-08-30 The Salk Institute For Biological Studies Gene expression system based on chimeric receptors
US20040033600A1 (en) 2001-03-21 2004-02-19 Palli Subba Reddy Ecdysone receptor-based inducible gene expression system
ATE338135T1 (de) * 2000-03-22 2006-09-15 Rheogene Holdings Inc Induziertes genexpressionssystem basierend auf ecdysonrezeptoren
US20020037514A1 (en) * 2000-03-24 2002-03-28 Klein Elliott S. Identification of nuclear receptor-dependent coregulator recruitment
US8105825B2 (en) 2000-10-03 2012-01-31 Intrexon Corporation Multiple inducible gene regulation system
ES2390070T3 (es) 2001-02-20 2012-11-06 Intrexon Corporation Nuevos receptores mutantes de sustitución y su uso en un sistema de expresión génica inducible basado en receptores nucleares
ATE545705T1 (de) 2001-02-20 2012-03-15 Intrexon Corp Neues induzierbares genexpressionssystem auf ecdysonrezeptor/invertebraten-retinoid-x-rezept r-basis
CA2438119C (en) 2001-02-20 2014-12-16 Rheogene Holdings, Inc. Chimeric retinoid x receptors and their use in a novel ecdysone receptor-based inducible gene expression system
WO2002066612A2 (en) 2001-02-20 2002-08-29 Rheogene, Inc. Novel substitution mutant receptors and their use in a nuclear receptor-based inducible gene expression system
JP2005507247A (ja) 2001-09-26 2005-03-17 レオジーン・ホールディングス，インコーポレーテッド コナジラミエクジソン受容体核酸、ポリペプチド、およびそれらの使用
JP2005532781A (ja) 2001-09-26 2005-11-04 レオジーン・ホールディングス，インコーポレーテッド ヨコバイエクジソン受容体核酸、ポリペプチド、およびそれらの使用
WO2003105489A1 (en) 2002-06-07 2003-12-18 The Trustees Of Columbia University Method and device for online dynamic semantic video compression and video indexing
US20050228016A1 (en) 2002-06-13 2005-10-13 Enrique Michelotti Tetrahydroquinolines for modulating the expression of exogenous genes via an ecdysone receptor complex
US7375093B2 (en) 2002-07-05 2008-05-20 Intrexon Corporation Ketone ligands for modulating the expression of exogenous genes via an ecdysone receptor complex
US7304161B2 (en) 2003-02-10 2007-12-04 Intrexon Corporation Diaclhydrazine ligands for modulating the expression of exogenous genes in mammalian systems via an ecdysone receptor complex
US7304162B2 (en) 2003-02-21 2007-12-04 Intrexon Corporation Oxadiazoline ligands for modulating the expression of exogenous genes via an ecdysone receptor complex
US7456315B2 (en) 2003-02-28 2008-11-25 Intrexon Corporation Bioavailable diacylhydrazine ligands for modulating the expression of exogenous genes via an ecdysone receptor complex
US7935510B2 (en) 2004-04-30 2011-05-03 Intrexon Corporation Mutant receptors and their use in a nuclear receptor-based inducible gene expression system
US9034650B2 (en) 2005-02-02 2015-05-19 Intrexon Corporation Site-specific serine recombinases and methods of their use
US8115059B1 (en) 2005-07-22 2012-02-14 University Of Kentucky Research Foundation Gene expression modulation system for use in plants and method for modulating gene expression in plants
US8471890B1 (en) 2009-12-30 2013-06-25 Insors Integrated Communications Adaptive video communication channel

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