BR9607300A - Polinucleotídeo transcrito de rna cdna vetor de dna biologicamente funcional célula hospedeira processo para produzir um polipeptídeo polipeptídeo produto de anticorpo hibridoma e linhagem de célula de hibridoma - Google Patents

Polinucleotídeo transcrito de rna cdna vetor de dna biologicamente funcional célula hospedeira processo para produzir um polipeptídeo polipeptídeo produto de anticorpo hibridoma e linhagem de célula de hibridoma

Info

Publication number
BR9607300A
BR9607300A BR9607300A BR9607300A BR9607300A BR 9607300 A BR9607300 A BR 9607300A BR 9607300 A BR9607300 A BR 9607300A BR 9607300 A BR9607300 A BR 9607300A BR 9607300 A BR9607300 A BR 9607300A
Authority
BR
Brazil
Prior art keywords
polypeptide
hybridoma
produce
dna vector
biologically functional
Prior art date
Application number
BR9607300A
Other languages
English (en)
Inventor
Patrick W Gray
Vicki L Schwickart
Carol J Raport
Original Assignee
Icos Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=24302427&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR9607300(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Icos Corp filed Critical Icos Corp
Publication of BR9607300A publication Critical patent/BR9607300A/pt

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/06Antipsoriatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/18Antivirals for RNA viruses for HIV
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C07K14/7158Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for chemokines
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/40Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
    • C07K2319/43Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation containing a FLAG-tag

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Virology (AREA)
  • Cell Biology (AREA)
  • Toxicology (AREA)
  • Rheumatology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Dermatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Diabetes (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pain & Pain Management (AREA)
  • AIDS & HIV (AREA)
  • Hematology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
BR9607300A 1995-12-20 1996-12-20 Polinucleotídeo transcrito de rna cdna vetor de dna biologicamente funcional célula hospedeira processo para produzir um polipeptídeo polipeptídeo produto de anticorpo hibridoma e linhagem de célula de hibridoma BR9607300A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/575,967 US6265184B1 (en) 1995-12-20 1995-12-20 Polynucleotides encoding chemokine receptor 88C
US08/661,393 US6268477B1 (en) 1995-12-20 1996-06-07 Chemokine receptor 88-C
PCT/US1996/020759 WO1997022698A2 (en) 1995-12-20 1996-12-20 Chemokine receptors 88-2b[ckr-3] and 88c and their antibodies

Publications (1)

Publication Number Publication Date
BR9607300A true BR9607300A (pt) 1997-11-25

Family

ID=24302427

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9607300A BR9607300A (pt) 1995-12-20 1996-12-20 Polinucleotídeo transcrito de rna cdna vetor de dna biologicamente funcional célula hospedeira processo para produzir um polipeptídeo polipeptídeo produto de anticorpo hibridoma e linhagem de célula de hibridoma

Country Status (17)

Country Link
US (7) US6265184B1 (pt)
EP (3) EP0811063B9 (pt)
JP (4) JP3288384B2 (pt)
CN (2) CN1827646A (pt)
AT (2) ATE458052T1 (pt)
AU (1) AU730463B2 (pt)
BR (1) BR9607300A (pt)
CA (1) CA2213331C (pt)
CZ (1) CZ261097A3 (pt)
DE (2) DE69635406T3 (pt)
DK (2) DK0811063T3 (pt)
ES (2) ES2255716T5 (pt)
HU (1) HUP9801127A3 (pt)
NO (2) NO973800L (pt)
PL (2) PL192071B1 (pt)
SK (1) SK112897A3 (pt)
WO (1) WO1997022698A2 (pt)

Families Citing this family (67)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6537764B1 (en) 1995-01-19 2003-03-25 Children's Medical Center Corporation Method of identifying inhibitors of C—C chemokine receptor 3
US6806061B1 (en) 1995-01-19 2004-10-19 Children's Medical Center Corporation G protein-coupled receptor gene and methods of use therefor
US20040151719A1 (en) * 1995-06-06 2004-08-05 Human Genome Sciences, Inc. Human G-protein chemokine receptor (CCR5) HDGNR10
US6025154A (en) 1995-06-06 2000-02-15 Human Genome Sciences, Inc. Polynucleotides encoding human G-protein chemokine receptor HDGNR10
US6743594B1 (en) 1995-06-06 2004-06-01 Human Genome Sciences, Inc. Methods of screening using human G-protein chemokine receptor HDGNR10 (CCR5)
US7018627B1 (en) 1995-06-07 2006-03-28 Icos Corporation Macrophage derived chemokine (MDC), MDC analogs, MDC inhibitor substances, and uses thereof
CA2224003C (en) * 1995-06-07 2010-04-13 Progenics Pharmaceuticals, Inc. Fluorescence resonance energy transfer screening assay for the identification of hiv-1 envelope glycoprotein-medicated cell
US6265184B1 (en) 1995-12-20 2001-07-24 Icos Corporation Polynucleotides encoding chemokine receptor 88C
US7118859B2 (en) * 1996-01-17 2006-10-10 Progenics Pharmaceuticals, Inc. Methods for inhibiting HIV-1 infection
EP0854918A1 (en) * 1996-01-30 1998-07-29 The National Institutes of Health Cells expressing both human cd4 and cxcr4
ES2227672T3 (es) * 1996-03-01 2005-04-01 Euroscreen S.A. C-c ckr-5, receptor de quimiocinas cc, derivados del mismo ysus usos.
US6344545B1 (en) * 1996-06-14 2002-02-05 Progenics Pharmaceuticals, Inc. Method for preventing HIV-1 infection of CD4+ cells
US7858298B1 (en) 1996-04-01 2010-12-28 Progenics Pharmaceuticals Inc. Methods of inhibiting human immunodeficiency virus type 1 (HIV-1) infection through the administration of CCR5 chemokine receptor antagonists
AU728512B2 (en) 1996-04-02 2001-01-11 Progenics Pharmaceuticals, Inc. Method for preventing HIV-1 infection of CD4+ cells
US6271347B1 (en) * 1996-04-26 2001-08-07 Merck & Co., Inc. Eosinophil eotaxin receptor
WO1997041154A1 (en) * 1996-04-26 1997-11-06 Merck & Co., Inc. Eosinophil eotaxin receptor
AU2813297A (en) * 1996-04-26 1997-11-19 Incyte Pharmaceuticals, Inc. Mammalian mixed lymphocyte receptors, chemokine receptors {mmlr-ccr}
US6258527B1 (en) 1996-05-20 2001-07-10 The Aaron Diamond Aids Research Center Methods of identifying g-coupled receptors associated with macrophage-trophic HIV, and diagnostic and therapeutic uses thereof
US5939320A (en) * 1996-05-20 1999-08-17 New York University G-coupled receptors associated with macrophage-trophic HIV, and diagnostic and therapeutic uses thereof
EP0975749A2 (en) * 1996-05-28 2000-02-02 THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES Cc chemokine receptor 5, antibodies thereto, transgenic animals
US20040086528A1 (en) * 1996-06-14 2004-05-06 Progenics Pharmaceuticals, Inc. Uses of a chemokine receptor for inhibiting HIV-1 infection
US6057102A (en) * 1996-08-08 2000-05-02 The Aaron Diamond Aids Research Center HIV coreceptor mutants
US6388055B1 (en) 1996-10-03 2002-05-14 Smithkline Beecham Corporation Mouse CC-CKR5 receptor polypeptide
US6528625B1 (en) 1996-10-28 2003-03-04 Millennium Pharmaceuticals, Inc. Anti-CCR5 antibodies and kits comprising same
US6153431A (en) * 1997-05-30 2000-11-28 Fond Mondiale Rech & Prev Sida Human immunodeficiency virus co-receptor variants associated with resistance to virus infection
US6465237B1 (en) * 1997-07-01 2002-10-15 Millennium Pharmaceuticals, Inc. Cloning and characterization of a human adenylyl cyclase
US6989435B2 (en) 1997-09-11 2006-01-24 Cambridge University Technical Services Ltd. Compounds and methods to inhibit or augment an inflammatory response
US7067117B1 (en) 1997-09-11 2006-06-27 Cambridge University Technical Services, Ltd. Compounds and methods to inhibit or augment an inflammatory response
US6204024B1 (en) * 1997-09-12 2001-03-20 Akzo Nobel N.V. CCR5 RNA transcription based amplification assay
US6287805B1 (en) 1998-03-20 2001-09-11 Millennium Pharmaceuticals, Inc. Nucleic acid molecules of the protein-coupled heptahelical receptor superfamily and uses therefor
CA2235420A1 (en) * 1998-06-17 1999-12-17 Paolo Renzi Antisense oligonucleotides for treating or preventing atopic diseases and neoplastic cell proliferation
US20040228869A1 (en) * 1998-12-16 2004-11-18 Progenics Pharmaceuticals, Inc. Synergistic inhibition of HIV-1 fusion and attachment, compositions and antibodies thereto
US20080015348A1 (en) * 1998-12-16 2008-01-17 Progenics Pharmaceuticals, Inc. Nucleic acids encoding polypeptides of anti-CCR5 antibodies
AU2610000A (en) 1999-01-12 2000-08-01 Cambridge University Technical Services Limited Compounds and methods to inhibit or augment an inflammatory response
US7238711B1 (en) 1999-03-17 2007-07-03 Cambridge University Technical Services Ltd. Compounds and methods to inhibit or augment an inflammatory response
AU2001243145A1 (en) * 2000-02-09 2001-08-20 Human Genome Sciences, Inc. Human g-protein chemokine receptor (ccr5) hdgnr10
WO2002014532A2 (en) 2000-08-15 2002-02-21 Millennium Pharmaceuticals, Inc. Method for identifying modulators of 'mec'-induced functions of ccr3 and/or ccr10
US7138119B2 (en) * 2000-09-15 2006-11-21 Progenics Pharmaceuticals, Inc. Compositions and methods for inhibition of HIV-1 infection
US7175988B2 (en) * 2001-02-09 2007-02-13 Human Genome Sciences, Inc. Human G-protein Chemokine Receptor (CCR5) HDGNR10
US7060273B2 (en) * 2001-04-06 2006-06-13 Progenics Pharmaceuticals, Inc. Methods for inhibiting HIV-1 infection
US20030104496A1 (en) * 2001-11-30 2003-06-05 Cytokinetics, Inc. Novel motor protein of P. falciparum and methods for its use
US7393934B2 (en) * 2001-12-21 2008-07-01 Human Genome Sciences, Inc. Human G-protein chemokine receptor (CCR5) HDGNR10
US20050069549A1 (en) 2002-01-14 2005-03-31 William Herman Targeted ligands
DK2230299T3 (da) * 2002-01-18 2012-03-26 Zymogenetics Inc Hidtil ukendt cytokin ZCYTOR17-ligand
US7122185B2 (en) * 2002-02-22 2006-10-17 Progenics Pharmaceuticals, Inc. Anti-CCR5 antibody
WO2003072014A2 (en) 2002-02-25 2003-09-04 Mpex Bioscience, Inc. Minicell compositions and methods
US7094848B2 (en) * 2003-05-13 2006-08-22 Exxonmobil Chemical Patents Inc. Olefin polymerization catalyst system
JP2008507255A (ja) * 2004-03-12 2008-03-13 ヒューマン ジノーム サイエンシーズ, インコーポレイテッド ヒトgタンパク質ケモカインレセプター(ccr5)hdgnr10
WO2005106492A2 (en) * 2004-04-30 2005-11-10 Bayer Healthcare Ag Diagnostics and therapeutics for diseases associated with c-c chemokine receptor 3 (ccr3)
ES2450929T3 (es) 2004-10-29 2014-03-25 Topigen Pharmaceuticals Inc. Oligonucleótidos antisentido para tratar la alergia y la proliferación de las células neoplásicas
ES2438019T3 (es) * 2005-07-22 2014-01-15 Cytodyn, Inc. Procedimientos para reducir la carga viral en pacientes infectados por el VIH-1
CA2658227A1 (en) 2006-01-17 2007-07-26 Health Research, Inc. Heteroduplex tracking assay
US20080283557A1 (en) * 2007-05-17 2008-11-20 Julianne Desautels Spout for food stuff container
US8200440B2 (en) 2007-05-18 2012-06-12 Affymetrix, Inc. System, method, and computer software product for genotype determination using probe array data
US20090074766A1 (en) * 2007-09-14 2009-03-19 Ketas Thomas J Methods of inhibiting HIV-2 infection
CA2793959C (en) 2010-03-25 2019-06-04 Oregon Health & Science University Cmv glycoproteins and recombinant vectors
CA2832109C (en) 2011-06-10 2021-07-06 Oregon Health & Science University Cmv glycoproteins and recombinant vectors
AU2012216792A1 (en) 2011-09-12 2013-03-28 International Aids Vaccine Initiative Immunoselection of recombinant vesicular stomatitis virus expressing HIV-1 proteins by broadly neutralizing antibodies
EP2586461A1 (en) 2011-10-27 2013-05-01 Christopher L. Parks Viral particles derived from an enveloped virus
EP2679596B1 (en) 2012-06-27 2017-04-12 International Aids Vaccine Initiative HIV-1 env glycoprotein variant
DE102013200909A1 (de) * 2013-01-22 2014-07-24 Robert Bosch Gmbh Brennstoffeinspritzanlage mit einer Brennstoff führenden Komponente, einem Brennstoffeinspritzventil und einem Verbindungselement
US20150065381A1 (en) 2013-09-05 2015-03-05 International Aids Vaccine Initiative Methods of identifying novel hiv-1 immunogens
EP2873423B1 (en) 2013-10-07 2017-05-31 International Aids Vaccine Initiative Soluble hiv-1 envelope glycoprotein trimers
US10174292B2 (en) 2015-03-20 2019-01-08 International Aids Vaccine Initiative Soluble HIV-1 envelope glycoprotein trimers
US9931394B2 (en) 2015-03-23 2018-04-03 International Aids Vaccine Initiative Soluble HIV-1 envelope glycoprotein trimers
CN106405067B (zh) * 2016-08-31 2018-03-30 徐州医科大学 一种基于全细胞的药物靶点停留时间的检测方法
JP6378735B2 (ja) * 2016-11-09 2018-08-22 本田技研工業株式会社 スイッチユニット

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4886742A (en) 1987-06-15 1989-12-12 Coulter Corporation Enzyme immunoassay for detecting HIV antigens in human sera
US4888920A (en) 1988-08-24 1989-12-26 Marulic Walter J Gutter anti-clogging device
US5215915A (en) 1991-04-16 1993-06-01 Duke University Cloned gene encoding rat d1b dopamine receptor
US6806061B1 (en) 1995-01-19 2004-10-19 Children's Medical Center Corporation G protein-coupled receptor gene and methods of use therefor
US6025154A (en) 1995-06-06 2000-02-15 Human Genome Sciences, Inc. Polynucleotides encoding human G-protein chemokine receptor HDGNR10
EP1146122A3 (en) 1995-06-06 2003-12-03 Human Genome Sciences, Inc. Human G-protein chemokine receptor HDGNR10 (CCR5 receptor)
WO1996039437A1 (en) 1995-06-06 1996-12-12 Human Genome Sciences, Inc. Human g-protein chemokine receptor hdgnr10
US6512103B1 (en) 1995-12-08 2003-01-28 Schering Corporation Mammalian chemokine reagents
US6265184B1 (en) 1995-12-20 2001-07-24 Icos Corporation Polynucleotides encoding chemokine receptor 88C
WO1997026009A1 (en) 1996-01-17 1997-07-24 Progenics Pharmaceuticals, Inc. Compounds capable of inhibiting hiv-1 infection
ES2227672T3 (es) 1996-03-01 2005-04-01 Euroscreen S.A. C-c ckr-5, receptor de quimiocinas cc, derivados del mismo ysus usos.
US5939320A (en) 1996-05-20 1999-08-17 New York University G-coupled receptors associated with macrophage-trophic HIV, and diagnostic and therapeutic uses thereof
EP0975749A2 (en) 1996-05-28 2000-02-02 THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES Cc chemokine receptor 5, antibodies thereto, transgenic animals
JP4183754B2 (ja) 1996-06-14 2008-11-19 プロジェニクス・ファーマスーティカルス・インコーポレーテッド Hiv―1感染を阻害するためのケモカイン受容体の使用
US5994515A (en) * 1996-06-25 1999-11-30 Trustees Of The University Of Pennsylvania Antibodies directed against cellular coreceptors for human immunodeficiency virus and methods of using the same

Also Published As

Publication number Publication date
JP3288384B2 (ja) 2002-06-04
EP0811063A2 (en) 1997-12-10
EP1642975A2 (en) 2006-04-05
DE69635406T2 (de) 2006-08-03
DK0811063T3 (da) 2006-04-10
EP1870465A3 (en) 2008-04-23
NO973800D0 (no) 1997-08-19
CZ261097A3 (cs) 1998-06-17
EP1870465B1 (en) 2010-02-17
WO1997022698A2 (en) 1997-06-26
EP1870465A2 (en) 2007-12-26
ATE458052T1 (de) 2010-03-15
ES2255716T3 (es) 2006-07-01
HUP9801127A2 (hu) 1998-08-28
NO973800L (no) 1997-10-20
ES2341371T3 (es) 2010-06-18
US20020150888A1 (en) 2002-10-17
JP2009065976A (ja) 2009-04-02
US6797811B1 (en) 2004-09-28
ATE309349T1 (de) 2005-11-15
JP2001029089A (ja) 2001-02-06
CA2213331A1 (en) 1997-06-26
AU1689297A (en) 1997-07-14
EP0811063B9 (en) 2014-04-23
SK112897A3 (en) 1998-07-08
US20050260565A1 (en) 2005-11-24
JP2001264324A (ja) 2001-09-26
CN1222617C (zh) 2005-10-12
US20080032336A1 (en) 2008-02-07
CA2213331C (en) 2011-09-27
JPH11503028A (ja) 1999-03-23
US6265184B1 (en) 2001-07-24
DE69635406D1 (de) 2005-12-15
US6268477B1 (en) 2001-07-31
PL192294B1 (pl) 2006-09-29
NO20052202L (no) 1997-10-20
ES2255716T5 (es) 2014-03-21
PL192071B1 (pl) 2006-08-31
NO20052202D0 (no) 2005-05-04
EP0811063B2 (en) 2013-12-04
EP0811063B1 (en) 2005-11-09
CN1827646A (zh) 2006-09-06
HUP9801127A3 (en) 2000-12-28
MX9706316A (es) 1997-11-29
WO1997022698A3 (en) 1997-09-12
CN1183805A (zh) 1998-06-03
DK1870465T3 (da) 2010-05-17
NO327506B1 (no) 2009-07-27
EP1642975A3 (en) 2006-04-12
PL321937A1 (en) 1998-01-05
US7662548B2 (en) 2010-02-16
AU730463B2 (en) 2001-03-08
DE69638128D1 (de) 2010-04-01
US20040230037A1 (en) 2004-11-18
DE69635406T3 (de) 2014-04-24

Similar Documents

Publication Publication Date Title
BR9607300A (pt) Polinucleotídeo transcrito de rna cdna vetor de dna biologicamente funcional célula hospedeira processo para produzir um polipeptídeo polipeptídeo produto de anticorpo hibridoma e linhagem de célula de hibridoma
DK1456346T3 (da) Nyt inducerbart genekspressionssystem baseret på ecdysonreceptor/invertebrat-retinoid-x-receptor
WO2001070816A3 (en) Ecdysone receptor-based inducible gene expression system
WO2002066615A3 (en) Novel substitution mutant receptors and their use in a nuclear receptor-based inducible gene expression system
EP2275558A3 (en) Novel substitution mutant receptors and their use in a nuclear receptor-based inducible gene expression system
PT96625A (pt) Processo para a preparacao de bancos de genes de anticorpos humanos ("bibliotecas de anticorpos humanos")
KR950032279A (ko) 인체의 프로그램된 세포 사멸과 관련 있는 펩티드 및 이를 암호하는 디엔에이(dna)
CA2153507A1 (en) A fas ligand, a fragment thereof and dna encoding the same
DE69634904D1 (de) Negativstrand rna virus mit selbständiger replikationsaktivität
KR940703857A (ko) 타이, 새로운 내피 세포 수용체 티로신 키나제(tie, a novel endothelial cell receptor tyrosine kinase)
ATE295740T1 (de) Modifizierte methioninase, deren verwendung, rekombinante wirtszellen die grosse mengen von methioninase produzieren und verfahren zur aufreinigung von methioninase
GR3019849T3 (en) Acute pancreatitis associated protein and means for the diagnosis of acute pancreatitis
BR9809778A (pt) Polinucleotìdeo isolado, vetor de expressão, peptìdeo ou polipetìdeo isolado, anticorpo, processo para produzir o mesmo, fragmentos de anticorpos, anticorpos de cadeia única ou anticorpos humanizados, e, anticorpo anti-idiotìpico.
ATE242808T1 (de) Cytoplasmatische expression von antikörpern, antikörperfragmenten und antikörperfragment- fusionsmolekülen in e. coli
BR9407874A (pt) Proteína purificada de mamiferos designada por mitosina fragmento biologicamente ativo proteina purificada de mamiferos molécula isolada de ácido nucléico vetor de expressao sistema de vetor-hospedeiro para produçao de mitosina anticorpo antimitosina e processo para produçao de mitosina
CN106459978A (zh) 附接有识别化合物的整料、该些整料的阵列及用途
BR9800937A (pt) Processo para produção de um anticorpo humanizado e derivados do mesmo e de uma proteìna de imunoglobuilina e para tratamento de doença autoimune, anticorpo humanizado ou um derivado do mesmo, rna, vetor replicável e célula hospedeira.
DE69431068D1 (de) Das polypeptid eines membran-proteins mit der funktion zur unterstützung des wachstums von prä-b zellen und sein gen
FR2528070B1 (fr) Vecteur d'expression porteur d'un codage genetique pour une proteine liant les phosphates, procede pour sa preparation et procede de production d'un polypeptide en l'utilisant
WO1994024164A3 (en) Human monoclonal antibodies and processes and materials for making such antibodies
CN112426520B (zh) 包含类泛素化修饰蛋白的药物组合物及其应用
Aiba et al. Distribution of gp138, a cell surface protein responsible for sexual cell fusion, among cellular slime moulds
BR9606557A (pt) Anticorpo monoclonal hibridoma polipeptídeo purificado e isolado polinucleotídeo purificado e isolado DNA célula hospedeira e método para produzir o polipeptídeo
ATE190653T1 (de) Verfahren zur herstellung von rekombinanten und synthetischen peptiden und deren verwendung
ATE196649T1 (de) Ein mutiertes crp-protein und verfahren und mittel zu dessen herstellung und verwendung

Legal Events

Date Code Title Description
FB36 Technical and formal requirements: requirement - article 36 of industrial property law
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: INDEFIROO PRESENTE PEDIDO DE PATENTE, COM BASE NO ARTTIGO 37, COMBINADO COM OS ARTIGOS 8O, 10( X) E 25 DA LPI 9.279/96

B12B Appeal against refusal [chapter 12.2 patent gazette]
B25A Requested transfer of rights approved

Owner name: EUROSCREEN S.A. (BE)

Free format text: TRANSFERIDO DE: ICOS CORPORATION