DE69634904D1 - Negativstrand rna virus mit selbständiger replikationsaktivität - Google Patents

Negativstrand rna virus mit selbständiger replikationsaktivität

Info

Publication number
DE69634904D1
DE69634904D1 DE69634904T DE69634904T DE69634904D1 DE 69634904 D1 DE69634904 D1 DE 69634904D1 DE 69634904 T DE69634904 T DE 69634904T DE 69634904 T DE69634904 T DE 69634904T DE 69634904 D1 DE69634904 D1 DE 69634904D1
Authority
DE
Germany
Prior art keywords
self
rna virus
replication activity
active replication
negative
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69634904T
Other languages
English (en)
Other versions
DE69634904T2 (de
Inventor
Yoshiyuki Nagai
Atsushi Kato
Fukashi Murai
Makoto Asakawa
Tsuneaki Sakata
Mamoru Hasegawa
Tatsuo Shioda
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Dnavec Research Inc
Original Assignee
Dnavec Research Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dnavec Research Inc filed Critical Dnavec Research Inc
Publication of DE69634904D1 publication Critical patent/DE69634904D1/de
Application granted granted Critical
Publication of DE69634904T2 publication Critical patent/DE69634904T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86Viral vectors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00Preparation of peptides or proteins
    • C12P21/02Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00Reverse transcribing RNA viruses
    • C12N2740/00011Details
    • C12N2740/10011Retroviridae
    • C12N2740/16011Human Immunodeficiency Virus, HIV
    • C12N2740/16111Human Immunodeficiency Virus, HIV concerning HIV env
    • C12N2740/16122New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011Details
    • C12N2760/18011Paramyxoviridae
    • C12N2760/18811Sendai virus
    • C12N2760/18821Viruses as such, e.g. new isolates, mutants or their genomic sequences
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011Details
    • C12N2760/18011Paramyxoviridae
    • C12N2760/18811Sendai virus
    • C12N2760/18822New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011Details
    • C12N2760/18011Paramyxoviridae
    • C12N2760/18811Sendai virus
    • C12N2760/18841Use of virus, viral particle or viral elements as a vector
    • C12N2760/18843Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011Details
    • C12N2760/18011Paramyxoviridae
    • C12N2760/18811Sendai virus
    • C12N2760/18851Methods of production or purification of viral material
    • C12N2760/18852Methods of production or purification of viral material relating to complementing cells and packaging systems for producing virus or viral particles
DE69634904T 1995-10-31 1996-10-22 Negativstrand rna virus mit selbständiger replikationsaktivität Expired - Lifetime DE69634904T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP30831595 1995-10-31
JP30831595 1995-10-31
PCT/JP1996/003068 WO1997016538A1 (fr) 1995-10-31 1996-10-22 Vecteur de virus d'arn a brin negatif possedant une activite de replication autonome

Publications (2)

Publication Number Publication Date
DE69634904D1 true DE69634904D1 (de) 2005-08-04
DE69634904T2 DE69634904T2 (de) 2006-05-18

Family

ID=17979579

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69634904T Expired - Lifetime DE69634904T2 (de) 1995-10-31 1996-10-22 Negativstrand rna virus mit selbständiger replikationsaktivität

Country Status (10)

Country Link
US (2) US6723532B2 (de)
EP (2) EP1325960A3 (de)
KR (2) KR100552387B1 (de)
CN (1) CN1118569C (de)
AT (1) ATE298789T1 (de)
AU (1) AU7335196A (de)
DE (1) DE69634904T2 (de)
DK (1) DK0864645T3 (de)
HK (1) HK1018287A1 (de)
WO (1) WO1997016538A1 (de)

Families Citing this family (68)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100525687B1 (ko) 1995-11-01 2005-11-25 가부시끼가이샤 디나벡 겡뀨쇼 재조합체 센다이바이러스
WO2000001837A1 (fr) * 1998-07-03 2000-01-13 Dnavec Research Inc. Vecteur de virus a arn a brin negatif
US7241617B2 (en) 1998-07-03 2007-07-10 Dnavec Research, Inc. Sendai viral vectors comprising foreign genes inserted between the R1 and R2 Loci
US6828138B1 (en) 1998-08-11 2004-12-07 Dnavec Research Inc. Recombinant sendai virus vector including a gene encoding a chemokine
ATE297991T1 (de) * 1998-08-11 2005-07-15 Dnavec Research Inc Rns virus vektor mit der fähigkeit zur kontaktinfiltration
US6544785B1 (en) 1998-09-14 2003-04-08 Mount Sinai School Of Medicine Of New York University Helper-free rescue of recombinant negative strand RNA viruses
US6514728B1 (en) 1998-11-09 2003-02-04 Nippon Biocaptal Limited Process for preparation of cytokines using Sendai virus expression system
US6490775B1 (en) * 1999-04-23 2002-12-10 Veri-Tek Inc. Press operation verification system
US7226786B2 (en) 1999-05-18 2007-06-05 Dnavec Research Inc. Envelope gene-deficient Paramyxovirus vector
AU4614600A (en) * 1999-05-18 2000-12-05 Dnavec Research Inc. Paramyxoviridae virus vector defective in envelope gene
US20030166252A1 (en) * 1999-05-18 2003-09-04 Kaio Kitazato Paramyxovirus-derived RNP
WO2001018223A1 (fr) * 1999-09-06 2001-03-15 Dnavec Research Inc. Paramoxyvirus possedant une sequence d'initiation de transcription modifiee
US7314614B1 (en) 1999-11-02 2008-01-01 Dnavec Research, Inc. Recombinant sendai virus vector for introducing exogenous genes to airway epithelia
JP4838962B2 (ja) * 1999-11-02 2011-12-14 株式会社ディナベック研究所 気道上皮細胞への外因性遺伝子導入用組換えセンダイウイルスベクター
US6875436B1 (en) 1999-11-19 2005-04-05 The Kitasata Institute Method for producing cell-fushion type morbillivirus mutants
KR100774796B1 (ko) * 2000-01-19 2007-11-07 가부시키가이샤 디나벡크 겐큐쇼 파라믹소바이러스 벡터의 혈관으로의 유전자 도입용도
JPWO2001072340A1 (ja) 2000-03-30 2004-01-08 株式会社ディナベック研究所 センダイウイルスベクターを用いたaidsウイルスワクチン
CA2322057A1 (en) 2000-05-18 2001-11-18 Dnavec Research Inc. Paramyxovirus vectors used for transfer of foreign genes
CA2413995C (en) * 2000-06-01 2013-08-13 Dnavec Research Inc. Pseudotype retroviral vectors containing membrane proteins having hemagglutinin activity
EP1297852A4 (de) * 2000-06-27 2004-12-29 Dnavec Research Inc Viraler vektor zur einbringung von genen in nierenzellen(03.02.03)
CN1526014A (zh) * 2000-10-06 2004-09-01 ��ʽ���������о��� 用于将外源基因导入骨骼肌的副粘病毒载体
JP2002142770A (ja) 2000-11-08 2002-05-21 Dnavec Research Inc 循環系への遺伝子送達用パラミクソウイルスベクター
WO2002042481A1 (fr) 2000-11-27 2002-05-30 Dnavec Research Inc. Vecteur paramyxovirus codant pour un gene d'angiogenese et son utilisation
US7465456B2 (en) 2002-04-26 2008-12-16 Medimmune, Llc Multi plasmid system for the production of influenza virus
KR101229202B1 (ko) 2002-04-26 2013-02-01 메디뮨 엘엘씨 인플루엔자 바이러스의 생산을 위한 다중 플라스미드 시스템
KR20040104673A (ko) * 2002-04-30 2004-12-10 가부시키가이샤 디나벡크 겐큐쇼 헤마글루티닌 활성을 저하시킨 약제 또는 유전자 운반 조성물
US7402427B2 (en) 2002-04-30 2008-07-22 Dnavec Research Inc. Vectors with modified protease-dependent tropism
CA2488270A1 (en) * 2002-06-03 2003-12-11 Dnavec Research Inc. Paramyxoviral vectors encoding antibodies, and uses thereof
EP1548101A4 (de) * 2002-09-04 2006-05-10 Dnavec Research Inc Verfahren zur herstellung eines viralen vektors, ein membranprotein enthaltend, welches mit hilfe von neuraminidase aus gram-positiven bakterien an sialinsäure als bestandteil des envelopes bindet
AU2003275581A1 (en) * 2002-10-24 2004-05-13 Dnavec Research Inc. Method of transferring gene into t cells
US7566458B2 (en) 2003-06-16 2009-07-28 Medimmune, Llc Influenza hemagglutinin and neuraminidase variants
US20070105208A1 (en) * 2003-06-30 2007-05-10 Jun You Minus strand rna virus vector carrying gene modified in high mutation region
CN1902312B (zh) 2003-11-04 2011-02-23 株式会社载体研究所 制备导入了基因的树突细胞的方法
CA2551489C (en) 2003-12-23 2013-09-03 Gregory Duke Multi plasmid system for the production of influenza virus
KR20060129013A (ko) 2004-01-13 2006-12-14 가부시키가이샤 디나벡크 겐큐쇼 면역자극성 사이토카인을 코드하는 마이너스 가닥 rna 바이러스 벡터를 사용하는 종양의 유전자 치료
WO2005071085A1 (ja) * 2004-01-22 2005-08-04 Dnavec Research Inc. ウイルスベクターの製造方法
JP4999330B2 (ja) 2004-01-22 2012-08-15 株式会社ディナベック研究所 サイトメガロウイルスエンハンサーおよびニワトリβ−アクチンプロモーターを含むハイブリッドプロモーターを利用したマイナス鎖RNAウイルスベクターの製造方法
US20080199438A1 (en) * 2004-03-16 2008-08-21 Dnavec Research Inc. Methods For Suppressing Tumor Proliferation
CN1957084A (zh) * 2004-03-23 2007-05-02 株式会社载体研究所 与组织的维持和/或修复相关联的骨髓相关细胞
US7504109B2 (en) 2004-05-25 2009-03-17 Medimmune, Llc Influenza hemagglutinin and neuraminidase variants
AU2005257105A1 (en) 2004-06-24 2006-01-05 Dnavec Research Inc. Anticancer agent containing minus-strand RNA virus
EP2471552B1 (de) 2005-03-08 2015-05-06 MedImmune, LLC Reassortierte Influenza-Viren
CA2612168A1 (en) * 2005-06-14 2006-12-21 Dnavec Corporation Methods for producing antibodies
JPWO2007049752A1 (ja) * 2005-10-28 2009-04-30 ディナベック株式会社 Rnaウイルスまたはdnaウイルスのスパイクタンパク質でシュードタイプ化したレンチウイルスベクターを用いた気道上皮幹細胞への遺伝子導入
KR20080094910A (ko) * 2006-01-17 2008-10-27 디나벡크 가부시키가이샤 신규 단백질 발현계
EP2034014A1 (de) 2006-05-31 2009-03-11 Dnavec Corporation Therapeutikum gegen morbus alzheimer
CN101517079A (zh) 2006-07-13 2009-08-26 生物载体株式会社 非复制型副粘病毒科病毒载体
EP2049662A4 (de) 2006-07-21 2009-12-30 Medimmune Llc Verfahren und zusammensetzungen zur erhöhung des replikationsvermögens eines influenza-virus
CN101983069B (zh) 2006-08-09 2014-07-16 米迪缪尼有限公司 流感血凝素和神经氨酸酶变体
JPWO2008029790A1 (ja) 2006-09-04 2010-01-21 協和発酵キリン株式会社 新規核酸
EP2123752A4 (de) 2006-12-18 2010-08-11 Kyowa Hakko Kirin Co Ltd Neuartige nukleinsäure
KR20090114431A (ko) 2007-02-07 2009-11-03 디나벡크 가부시키가이샤 약독화 마이너스 가닥 rna 바이러스
US20100203027A1 (en) 2007-04-27 2010-08-12 Kyushu Univeristy National University Viral vector for gene therapy
EP2069484B1 (de) 2007-06-18 2014-08-13 MedImmune, LLC Influenza-B-Viruses mit verändertem Hämagglutininpolypeptid
JPWO2009044899A1 (ja) 2007-10-03 2011-02-17 協和発酵キリン株式会社 細胞の増殖を制御する核酸
EP2298359A1 (de) 2008-06-04 2011-03-23 Kyowa Hakko Kirin Co., Ltd. Nukleinsäure zur steuerung der degranulation bei mastzellen
RU2523587C2 (ru) 2008-07-11 2014-07-20 МЕДИММЬЮН, ЭлЭлСи Варианты гемагглютинина и нейрамидазы вируса гриппа
CN102159710B (zh) 2008-07-16 2015-09-02 生物载体株式会社 使用染色体非整合型病毒载体制造经初始化的细胞的方法
US20120088819A1 (en) 2008-10-31 2012-04-12 Makoto Inoue Method for enhancing expression of recombinant protein
AU2010213966B2 (en) 2009-02-12 2015-01-22 Medimmune, Llc Influenza hemagglutinin and neuraminidase variants
WO2011083881A1 (ja) 2010-01-08 2011-07-14 国立大学法人京都大学 タウオパチー治療用ワクチン
JP5908838B2 (ja) 2010-08-30 2016-04-26 株式会社Idファーマ 多能性幹細胞を誘導するための組成物およびその使用
CN105916980A (zh) 2013-09-24 2016-08-31 株式会社爱迪药业 用于改进诱导多能干细胞的效率的方法
US11103574B2 (en) 2016-11-17 2021-08-31 Japan, as represented by the Director-General of National Institute of Infectious Disease Infectious disease vaccine using non-infectious paramyxovirus particle
CA3070552A1 (en) 2017-07-21 2019-01-24 I'rom Group Co., Ltd. Polynucleotide for modifying target sequence and use thereof
CN112135908A (zh) 2018-01-22 2020-12-25 国立传染病研究所长代表日本国 选择性cd8阳性t细胞诱导疫苗抗原
US20230220025A1 (en) 2020-09-04 2023-07-13 Heartseed Inc. Quality Improving Agent for IPS Cells, Method of Producing IPS Cells, IPS Cells, and Composition for Producing IPS Cells
WO2022138964A1 (ja) 2020-12-25 2022-06-30 国立大学法人京都大学 体細胞からのナイーブ型ヒトiPS細胞製造方法

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5166057A (en) * 1989-08-28 1992-11-24 The Mount Sinai School Of Medicine Of The City University Of New York Recombinant negative strand rna virus expression-systems
AU7007491A (en) * 1990-02-02 1991-08-08 Schweiz. Serum- & Impfinstitut Bern Cdna corresponding to the genome of negative-strand rna viruses, and process for the production of infectious negative-strand rna viruses
JP3029272B2 (ja) 1990-05-29 2000-04-04 邦忠 下遠野 構造蛋白質遺伝子、組換えベクター、組換えウイルス、ポリペプチドおよびポリペプチドの製造方法
US5665362A (en) 1990-09-25 1997-09-09 Cantab Pharmaceuticals Research Limited Viral vaccines
US5318898A (en) * 1991-04-02 1994-06-07 Genetics Institute, Inc. Production of recombinant bone-inducing proteins
JPH0585943A (ja) 1991-07-18 1993-04-06 Tonen Corp 組換えワクシニアウイルスを用いる非a非b型肝炎ウイルス遺伝子の発現および非a非b型肝炎ワクチン
JPH05301895A (ja) 1992-04-22 1993-11-16 Nippon Zeon Co Ltd ハイブリッド抗原タンパク質、それを発現する組み換えウイルス、及びその製造方法
ZA937164B (en) * 1992-09-28 1994-05-23 Commw Scient Ind Res Org Delivery system
US5516720A (en) 1994-02-14 1996-05-14 United Microelectronics Corporation Stress relaxation in dielectric before metallization
ATE257175T1 (de) 1994-07-18 2004-01-15 Conzelmann Karl Klaus Prof Dr Rekombinantes infektiöses nicht-in-segmente- geteiltes, negativ-strange-rns-virus
WO1996010400A1 (en) 1994-09-30 1996-04-11 The Uab Research Foundation Gene therapy vectors and vaccines based on non-segmented negatives stranded rna viruses
US5716821A (en) 1994-09-30 1998-02-10 Uab Research Foundation Prevention and treatment of respiratory tract disease
DE69510207T3 (de) 1995-08-09 2007-02-15 Schweiz. Serum- & Impfinstitut Bern Verfahren zur Herstellung von infektiösen minussträngigen RNA-Viren
KR0179554B1 (ko) * 1995-11-30 1999-04-15 김주용 반도체 소자의 소자분리절연막 형성방법
AU2749297A (en) 1996-05-01 1997-11-19 Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The Generation of viral transfectants using recombinant DNA-derived nucleoc apsid proteins

Also Published As

Publication number Publication date
EP0864645A4 (de) 2000-01-26
WO1997016538A1 (fr) 1997-05-09
US6723532B2 (en) 2004-04-20
KR100754091B1 (ko) 2007-08-31
AU7335196A (en) 1997-05-22
EP0864645B9 (de) 2006-03-22
CN1207123A (zh) 1999-02-03
CN1118569C (zh) 2003-08-20
KR19990067232A (ko) 1999-08-16
ATE298789T1 (de) 2005-07-15
DK0864645T3 (da) 2005-10-24
US20020100066A1 (en) 2002-07-25
EP1325960A2 (de) 2003-07-09
KR100552387B1 (ko) 2006-04-21
EP1325960A3 (de) 2004-09-15
US20020081706A1 (en) 2002-06-27
US6645760B2 (en) 2003-11-11
KR20050084302A (ko) 2005-08-26
EP0864645B1 (de) 2005-06-29
EP0864645A1 (de) 1998-09-16
HK1018287A1 (en) 1999-12-17
DE69634904T2 (de) 2006-05-18

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