DE69232188T2 - Verwendung von selektiven liganden zur behandlung von hormonansprechenden krankheitzuständen - Google Patents
Verwendung von selektiven liganden zur behandlung von hormonansprechenden krankheitzuständenInfo
- Publication number
- DE69232188T2 DE69232188T2 DE69232188T DE69232188T DE69232188T2 DE 69232188 T2 DE69232188 T2 DE 69232188T2 DE 69232188 T DE69232188 T DE 69232188T DE 69232188 T DE69232188 T DE 69232188T DE 69232188 T2 DE69232188 T2 DE 69232188T2
- Authority
- DE
- Germany
- Prior art keywords
- steroid
- disease conditions
- hormone
- selective ligands
- treating hormone
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 201000010099 disease Diseases 0.000 title abstract 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title abstract 3
- 239000003446 ligand Substances 0.000 title abstract 3
- 229940088597 hormone Drugs 0.000 abstract 2
- 239000005556 hormone Substances 0.000 abstract 2
- 230000003637 steroidlike Effects 0.000 abstract 2
- 150000003431 steroids Chemical class 0.000 abstract 2
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/07—Retinol compounds, e.g. vitamin A
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
- A61K31/203—Retinoic acids ; Salts thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US74876791A | 1991-08-23 | 1991-08-23 | |
PCT/US1992/007064 WO1993003713A1 (en) | 1991-08-23 | 1992-08-21 | Use of selective ligands for treatment of disease states responsive to steroid or steroid-like hormones |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69232188D1 DE69232188D1 (de) | 2001-12-13 |
DE69232188T2 true DE69232188T2 (de) | 2002-06-20 |
Family
ID=25010830
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69232188T Expired - Fee Related DE69232188T2 (de) | 1991-08-23 | 1992-08-21 | Verwendung von selektiven liganden zur behandlung von hormonansprechenden krankheitzuständen |
Country Status (8)
Country | Link |
---|---|
US (1) | US6096787A (de) |
EP (2) | EP1120113A3 (de) |
JP (1) | JPH07505607A (de) |
AT (1) | ATE208194T1 (de) |
AU (1) | AU2516092A (de) |
CA (1) | CA2114936C (de) |
DE (1) | DE69232188T2 (de) |
WO (1) | WO1993003713A1 (de) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2722985B1 (fr) * | 1994-07-27 | 1996-09-13 | Cird Galderma | Nouvelles compositions a base d'un melange synergetique entre au moins un ligand specifique des rxrs et au moins un ligand specifique de rar-x ou de vdr, et leurs utilisations |
FR2723315B1 (fr) * | 1994-08-02 | 1996-10-25 | Cird Galderma | Procede et composition pour stimuler la differenciation des cellules preadipocytaires et traitements therapeutiques associes |
US5807900A (en) * | 1995-03-31 | 1998-09-15 | Hoffmann-La Roche, Inc. | Method for identifying compounds having increased activity for the repair of skin photodamage |
US5624957A (en) * | 1995-06-06 | 1997-04-29 | Bristol-Myers Squibb Company | Rary-specific retinobenzoic acid derivatives |
DE69627193T2 (de) | 1995-10-06 | 2004-01-29 | Ligand Pharm Inc | Dimer-selektive rxr modulatoren und verfahren zu ihrer verwendung |
US5965606A (en) * | 1995-12-29 | 1999-10-12 | Allergan Sales, Inc. | Methods of treatment with compounds having RAR.sub.α receptor specific or selective activity |
US5919970A (en) * | 1997-04-24 | 1999-07-06 | Allergan Sales, Inc. | Substituted diaryl or diheteroaryl methanes, ethers and amines having retinoid agonist, antagonist or inverse agonist type biological activity |
FR2802808B1 (fr) * | 1999-12-22 | 2002-08-09 | Oreal | Utilisation de composes polycycliques aromatiques en tant qu'activateurs des recepteurs de type ppars dans une composition cosmetique ou pharmaceutique |
US20040033600A1 (en) | 2001-03-21 | 2004-02-19 | Palli Subba Reddy | Ecdysone receptor-based inducible gene expression system |
US8105825B2 (en) * | 2000-10-03 | 2012-01-31 | Intrexon Corporation | Multiple inducible gene regulation system |
JP4994563B2 (ja) | 2001-02-20 | 2012-08-08 | イントレキソン コーポレーション | 新規置換突然変異体受容体および核受容体−ベースの誘導性遺伝子発現システムにおけるその使用 |
MXPA03007493A (es) | 2001-02-20 | 2004-10-15 | Rheogene Holdings Inc | Nuevo sistema de expresion genetica inducible a base de receptor de ecdisona/receptor x retinoide de invertebrado. |
EP1572862B1 (de) * | 2001-02-20 | 2012-08-01 | Intrexon Corporation | Chimäre retinoid-x-rezeptoren und ihre verwendung in einem neuen induzierbaren genexpressionssystem auf ecdysonrezeptor-basis |
DK1373470T3 (da) | 2001-02-20 | 2013-07-29 | Intrexon Corp | Hidtil ukendte substitutionsmutantreceptorer og deres anvendelse i et cellekernereceptorbaseret inducerbart genekspressionssystem |
DE10244149A1 (de) * | 2001-09-25 | 2003-04-30 | Werner Keber | Verfahren und Einrichtung zum Verhindern einer unzulässigen Flugannäherung von Flugzeugen an zu schützende Bodenobjeke |
CA2930389A1 (en) | 2001-09-26 | 2003-04-03 | Intrexon Corporation | Whitefly ecdysone receptor nucleic acids, polypeptides, and uses thereof |
US7563879B2 (en) * | 2001-09-26 | 2009-07-21 | Intrexon Corporation | Leafhopper ecdysone receptor nucleic acids, polypeptides, and uses thereof |
US7304161B2 (en) * | 2003-02-10 | 2007-12-04 | Intrexon Corporation | Diaclhydrazine ligands for modulating the expression of exogenous genes in mammalian systems via an ecdysone receptor complex |
US7456315B2 (en) * | 2003-02-28 | 2008-11-25 | Intrexon Corporation | Bioavailable diacylhydrazine ligands for modulating the expression of exogenous genes via an ecdysone receptor complex |
US7935510B2 (en) * | 2004-04-30 | 2011-05-03 | Intrexon Corporation | Mutant receptors and their use in a nuclear receptor-based inducible gene expression system |
WO2010032582A1 (ja) * | 2008-09-22 | 2010-03-25 | 国立大学法人鹿児島大学 | 成人t細胞白血病治療薬 |
DK2970106T3 (en) | 2013-03-15 | 2018-08-13 | Intrexon Corp | CONTAINING DIACYL HYDRAZINES |
AU2015317862A1 (en) | 2014-09-17 | 2017-04-06 | Intrexon Corporation | Boron-containing diacylhydrazine compounds |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3580134D1 (de) * | 1984-07-07 | 1990-11-22 | Shudo Koichi Prof Dr Chem | Benzoesaeurederivate. |
IL80270A0 (en) * | 1985-10-11 | 1987-01-30 | Cird | Naphthalene derivatives,their preparation and pharmaceutical compositions containing them |
US4981784A (en) * | 1987-12-02 | 1991-01-01 | The Salk Institute For Biological Studies | Retinoic acid receptor method |
-
1992
- 1992-08-21 WO PCT/US1992/007064 patent/WO1993003713A1/en active IP Right Grant
- 1992-08-21 AU AU25160/92A patent/AU2516092A/en not_active Abandoned
- 1992-08-21 AT AT92919124T patent/ATE208194T1/de active
- 1992-08-21 CA CA002114936A patent/CA2114936C/en not_active Expired - Fee Related
- 1992-08-21 EP EP01103552A patent/EP1120113A3/de not_active Ceased
- 1992-08-21 JP JP5504607A patent/JPH07505607A/ja active Pending
- 1992-08-21 EP EP92919124A patent/EP0600028B1/de not_active Expired - Lifetime
- 1992-08-21 DE DE69232188T patent/DE69232188T2/de not_active Expired - Fee Related
-
1997
- 1997-09-16 US US08/931,694 patent/US6096787A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
WO1993003713A1 (en) | 1993-03-04 |
CA2114936C (en) | 2004-02-10 |
EP0600028B1 (de) | 2001-11-07 |
EP0600028A1 (de) | 1994-06-08 |
US6096787A (en) | 2000-08-01 |
ATE208194T1 (de) | 2001-11-15 |
DE69232188D1 (de) | 2001-12-13 |
JPH07505607A (ja) | 1995-06-22 |
CA2114936A1 (en) | 1993-03-04 |
EP1120113A2 (de) | 2001-08-01 |
AU2516092A (en) | 1993-03-16 |
EP1120113A3 (de) | 2003-05-07 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DE69232188D1 (de) | Verwendung von selektiven liganden zur behandlung von hormonansprechenden krankheitzuständen | |
DE69328981T2 (de) | Verfahren zur Behandlung von hyperproliferaktiven Gefässerkrankungen unter Verwendung von Rapamycin, eventuell in Kombination mit Mykophenolsäure | |
DE68907909D1 (de) | Praeparat zur behandlung von erektionsstoerungen. | |
DE69012261T2 (de) | Verwendung von Sertralin zur Behandlung verfrühter Ejakulation. | |
DE3779346D1 (de) | Zusammensetzung zur behandlung der haut. | |
DE3482754D1 (de) | Medikament und medikamentoese zusammensetzung zur behandlung und/oder verhinderung von hautkrankheiten, verursacht durch eine entzuendung. | |
NO883306D0 (no) | Farmasoeytisk aktive konjugater med forbedret bindingsspesifisitet for kroppsvev. | |
RU93054017A (ru) | Способ лечения остеопороза, композиция для лечения остеопороза, применение активно действующего на кости фосфоната и эстрогенного гормона для лечения остеопороза | |
NL960024I1 (nl) | Farmaceutisch preparaat omvattend 3'-deoxythymidine-2'-een (3'-deoxy-2',3'-didehydrothymidine) voor de behandeling van met retrovirus gesmette patiënten. | |
DE69116380D1 (de) | Pharmazeutische zubereitung zur behandlung verlängerter gerinnungszeit | |
ATE72755T1 (de) | Verbaende. | |
DE69013999D1 (de) | Siliconkautschukzusammensetzung zur Behandlung von Faserstrukturen. | |
DE69200684T2 (de) | Vorrichtung zur thermischen Behandlung von laufenden Garnen. | |
DE69638281D1 (de) | Anti-Interleukin-9 Antikörper oder Anti-Interleukin-9 Rezeptor Antikörper zur Behandlung von bronchialem Hyperreaktionsvermögen | |
DE3782214T2 (de) | Mittel zur behandlung des scheidenmilieus. | |
DE3650505T2 (de) | AICA riboside zur prophylaktischen Behandlung von Krankheiten mit einer verminderten Durchblutung. | |
ATE281841T1 (de) | Verfahren zur herstellung von mikania extrakten enthaltend mikanolide und dihydromikanolide und verwendung in der behandlung proliferativer erkrankungen | |
DE3786895D1 (de) | Bleichfixierloesung mit einer guten behandlungswirkung und verfahren zur behandlung eines lichtempfindlichen materials, das diese verwendet. | |
DE3861764D1 (de) | Verfahren und vorrichtung zur diskontinuierlichen nassbehandlung von gestricktem oder gewirktem textilgut. | |
DE69004529T2 (de) | Verwendung von Sertralin zur Behandlung von Abhängigkeiten von chemischen Stoffen. | |
ATE110961T1 (de) | Behandlung von beatmungsabhängigkeit mit wachstumshormon. | |
DE69428112D1 (de) | Verwendung von thymosin zur behandlung von hepatitis c bei patienten, die auf interferongaben nicht ansprechen | |
DE3768042D1 (de) | Maschine zur behandlung von photographischen filmen. | |
DE69219039D1 (de) | Verwendung von Felbamate zur Herstellung eines Arzneimittels zur Behandlung neuropsychopharmakologischer Störungen | |
DE69430807D1 (de) | Verfahren zur behandlung von lebererkrankungen und ähnlichen indikationen mit vasodilatierenden wirkstoffen |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |