DE69232188D1 - Verwendung von selektiven liganden zur behandlung von hormonansprechenden krankheitzuständen - Google Patents
Verwendung von selektiven liganden zur behandlung von hormonansprechenden krankheitzuständenInfo
- Publication number
- DE69232188D1 DE69232188D1 DE69232188T DE69232188T DE69232188D1 DE 69232188 D1 DE69232188 D1 DE 69232188D1 DE 69232188 T DE69232188 T DE 69232188T DE 69232188 T DE69232188 T DE 69232188T DE 69232188 D1 DE69232188 D1 DE 69232188D1
- Authority
- DE
- Germany
- Prior art keywords
- steroid
- disease conditions
- hormone
- selective ligands
- treating hormone
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 201000010099 disease Diseases 0.000 title abstract 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title abstract 3
- 239000003446 ligand Substances 0.000 title abstract 3
- 229940088597 hormone Drugs 0.000 abstract 2
- 239000005556 hormone Substances 0.000 abstract 2
- 230000003637 steroidlike Effects 0.000 abstract 2
- 150000003431 steroids Chemical class 0.000 abstract 2
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/07—Retinol compounds, e.g. vitamin A
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
- A61K31/203—Retinoic acids ; Salts thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Oncology (AREA)
- Endocrinology (AREA)
- Dermatology (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Steroid Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US74876791A | 1991-08-23 | 1991-08-23 | |
PCT/US1992/007064 WO1993003713A1 (en) | 1991-08-23 | 1992-08-21 | Use of selective ligands for treatment of disease states responsive to steroid or steroid-like hormones |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69232188D1 true DE69232188D1 (de) | 2001-12-13 |
DE69232188T2 DE69232188T2 (de) | 2002-06-20 |
Family
ID=25010830
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69232188T Expired - Fee Related DE69232188T2 (de) | 1991-08-23 | 1992-08-21 | Verwendung von selektiven liganden zur behandlung von hormonansprechenden krankheitzuständen |
Country Status (8)
Country | Link |
---|---|
US (1) | US6096787A (de) |
EP (2) | EP1120113A3 (de) |
JP (1) | JPH07505607A (de) |
AT (1) | ATE208194T1 (de) |
AU (1) | AU2516092A (de) |
CA (1) | CA2114936C (de) |
DE (1) | DE69232188T2 (de) |
WO (1) | WO1993003713A1 (de) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2722985B1 (fr) * | 1994-07-27 | 1996-09-13 | Cird Galderma | Nouvelles compositions a base d'un melange synergetique entre au moins un ligand specifique des rxrs et au moins un ligand specifique de rar-x ou de vdr, et leurs utilisations |
FR2723315B1 (fr) * | 1994-08-02 | 1996-10-25 | Cird Galderma | Procede et composition pour stimuler la differenciation des cellules preadipocytaires et traitements therapeutiques associes |
US5807900A (en) * | 1995-03-31 | 1998-09-15 | Hoffmann-La Roche, Inc. | Method for identifying compounds having increased activity for the repair of skin photodamage |
US5624957A (en) * | 1995-06-06 | 1997-04-29 | Bristol-Myers Squibb Company | Rary-specific retinobenzoic acid derivatives |
EP1336600A3 (de) | 1995-10-06 | 2004-07-07 | Ligand Pharmaceuticals Incorporated | Dimer-selektive rxr Modulatoren und Verfahren zu ihrer Verwendung |
US5965606A (en) | 1995-12-29 | 1999-10-12 | Allergan Sales, Inc. | Methods of treatment with compounds having RAR.sub.α receptor specific or selective activity |
US5919970A (en) * | 1997-04-24 | 1999-07-06 | Allergan Sales, Inc. | Substituted diaryl or diheteroaryl methanes, ethers and amines having retinoid agonist, antagonist or inverse agonist type biological activity |
FR2802808B1 (fr) * | 1999-12-22 | 2002-08-09 | Oreal | Utilisation de composes polycycliques aromatiques en tant qu'activateurs des recepteurs de type ppars dans une composition cosmetique ou pharmaceutique |
US20040033600A1 (en) * | 2001-03-21 | 2004-02-19 | Palli Subba Reddy | Ecdysone receptor-based inducible gene expression system |
US8105825B2 (en) * | 2000-10-03 | 2012-01-31 | Intrexon Corporation | Multiple inducible gene regulation system |
EP1373470B1 (de) | 2001-02-20 | 2013-04-24 | Intrexon Corporation | Neue substitutionsmutantenrezeptoren und ihre verwendung in einem induzierbaren genexpressionssystem auf basis eines nukleären rezeptors |
US7531326B2 (en) | 2001-02-20 | 2009-05-12 | Intrexon Corporation | Chimeric retinoid X receptors and their use in a novel ecdysone receptor-based inducible gene expression system |
AU2002248500B2 (en) | 2001-02-20 | 2007-12-13 | Intrexon Corporation | Novel substitution mutant receptors and their use in a nuclear receptor-based inducible gene expression system |
DK1456346T3 (da) | 2001-02-20 | 2012-05-29 | Intrexon Corp | Nyt inducerbart genekspressionssystem baseret på ecdysonreceptor/invertebrat-retinoid-x-receptor |
US7177763B2 (en) * | 2001-09-25 | 2007-02-13 | Werner Keber | Method and device for preventing unpermitted approach of airplanes to objects on the ground which are to be protected |
US7563879B2 (en) * | 2001-09-26 | 2009-07-21 | Intrexon Corporation | Leafhopper ecdysone receptor nucleic acids, polypeptides, and uses thereof |
CA2820170C (en) * | 2001-09-26 | 2016-07-05 | Intrexon Corporation | Whitefly ecdysone receptor nucleic acids, polypeptides, and uses thereof |
US7304161B2 (en) * | 2003-02-10 | 2007-12-04 | Intrexon Corporation | Diaclhydrazine ligands for modulating the expression of exogenous genes in mammalian systems via an ecdysone receptor complex |
US7456315B2 (en) | 2003-02-28 | 2008-11-25 | Intrexon Corporation | Bioavailable diacylhydrazine ligands for modulating the expression of exogenous genes via an ecdysone receptor complex |
US7935510B2 (en) * | 2004-04-30 | 2011-05-03 | Intrexon Corporation | Mutant receptors and their use in a nuclear receptor-based inducible gene expression system |
BRPI0919348A2 (pt) * | 2008-09-22 | 2015-12-29 | Kagosima University | fármaco terapêutico para leucemia da célula t adulta. |
MX361717B (es) | 2013-03-15 | 2018-12-14 | Intrexon Corp | Diacilhidrazinas que contienen boro. |
WO2016044390A1 (en) | 2014-09-17 | 2016-03-24 | Intrexon Corporation | Boron-containing diacylhydrazine compounds |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0170105B1 (de) * | 1984-07-07 | 1990-10-17 | Koichi Prof. Dr. Shudo | Benzoesäurederivate |
IL80270A0 (en) * | 1985-10-11 | 1987-01-30 | Cird | Naphthalene derivatives,their preparation and pharmaceutical compositions containing them |
US4981784A (en) * | 1987-12-02 | 1991-01-01 | The Salk Institute For Biological Studies | Retinoic acid receptor method |
-
1992
- 1992-08-21 AT AT92919124T patent/ATE208194T1/de active
- 1992-08-21 EP EP01103552A patent/EP1120113A3/de not_active Ceased
- 1992-08-21 WO PCT/US1992/007064 patent/WO1993003713A1/en active IP Right Grant
- 1992-08-21 CA CA002114936A patent/CA2114936C/en not_active Expired - Fee Related
- 1992-08-21 JP JP5504607A patent/JPH07505607A/ja active Pending
- 1992-08-21 DE DE69232188T patent/DE69232188T2/de not_active Expired - Fee Related
- 1992-08-21 AU AU25160/92A patent/AU2516092A/en not_active Abandoned
- 1992-08-21 EP EP92919124A patent/EP0600028B1/de not_active Expired - Lifetime
-
1997
- 1997-09-16 US US08/931,694 patent/US6096787A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
ATE208194T1 (de) | 2001-11-15 |
DE69232188T2 (de) | 2002-06-20 |
EP0600028A1 (de) | 1994-06-08 |
EP1120113A3 (de) | 2003-05-07 |
WO1993003713A1 (en) | 1993-03-04 |
EP0600028B1 (de) | 2001-11-07 |
CA2114936A1 (en) | 1993-03-04 |
CA2114936C (en) | 2004-02-10 |
AU2516092A (en) | 1993-03-16 |
US6096787A (en) | 2000-08-01 |
JPH07505607A (ja) | 1995-06-22 |
EP1120113A2 (de) | 2001-08-01 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |