DE69334246D1 - Verbesserte reagentien und methoden zur diagnose und behandlung von diabetes und stiff man syndrome - Google Patents
Verbesserte reagentien und methoden zur diagnose und behandlung von diabetes und stiff man syndromeInfo
- Publication number
- DE69334246D1 DE69334246D1 DE69334246T DE69334246T DE69334246D1 DE 69334246 D1 DE69334246 D1 DE 69334246D1 DE 69334246 T DE69334246 T DE 69334246T DE 69334246 T DE69334246 T DE 69334246T DE 69334246 D1 DE69334246 D1 DE 69334246D1
- Authority
- DE
- Germany
- Prior art keywords
- diabetes
- diagnosis
- treatment
- methods
- man syndrome
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 206010072148 Stiff-Person syndrome Diseases 0.000 title 1
- 239000003153 chemical reaction reagent Substances 0.000 title 1
- 206010012601 diabetes mellitus Diseases 0.000 title 1
- 238000003745 diagnosis Methods 0.000 title 1
- 238000000034 method Methods 0.000 title 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/564—Immunoassay; Biospecific binding assay; Materials therefor for pre-existing immune complex or autoimmune disease, i.e. systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, rheumatoid factors or complement components C1-C9
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/88—Lyases (4.)
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/573—Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/04—Endocrine or metabolic disorders
- G01N2800/042—Disorders of carbohydrate metabolism, e.g. diabetes, glucose metabolism
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/24—Immunology or allergic disorders
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/811—Test for named disease, body condition or organ function
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US98493592A | 1992-12-03 | 1992-12-03 | |
PCT/US1993/011705 WO1994012529A1 (en) | 1992-12-03 | 1993-12-02 | Improved reagents and methods for the diagnosis and treatment of diabetes and stiff man syndrome |
Publications (1)
Publication Number | Publication Date |
---|---|
DE69334246D1 true DE69334246D1 (de) | 2008-12-24 |
Family
ID=25531040
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69334246T Expired - Lifetime DE69334246D1 (de) | 1992-12-03 | 1993-12-02 | Verbesserte reagentien und methoden zur diagnose und behandlung von diabetes und stiff man syndrome |
Country Status (7)
Country | Link |
---|---|
US (3) | US5691448A (de) |
EP (1) | EP0701569B1 (de) |
JP (2) | JP4242446B2 (de) |
DE (1) | DE69334246D1 (de) |
DK (1) | DK0701569T3 (de) |
ES (1) | ES2318847T3 (de) |
WO (1) | WO1994012529A1 (de) |
Families Citing this family (34)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5762937A (en) * | 1988-12-13 | 1998-06-09 | University Of Florida Research Foundation, Inc. | Methods and compositions for the early detection and treatment of insulin dependent diabetes mellitus |
ES2318847T3 (es) * | 1992-12-03 | 2009-05-01 | The Regents Of The University Of California | Metodos y reactivos mejorados para el diagnostico y el tratamiento de diabetes y del sindrome de stiff man. |
US5891435A (en) * | 1993-04-16 | 1999-04-06 | Research Corporation Technologies, Inc. | Methods and compositions for delaying or preventing the onset of autoimmune disease |
CN1112933A (zh) | 1994-01-20 | 1995-12-06 | 伯伦格·曼海姆有限公司 | 抗原特异性活化t淋巴细胞,其检测和用途 |
DE69637130T2 (de) | 1995-02-20 | 2008-02-21 | The Walter And Eliza Hall Institute Of Medical Research, Parkville | Immunoreaktive und immunotherapeutische moleküle welche in individuen mit insulin-abhängiger diabetes mellitus interagieren |
AU706774B2 (en) * | 1995-02-20 | 1999-06-24 | Walter And Eliza Hall Institute Of Medical Research, The | Immunoreactive and immunotherapeutic molecules which interact in subjects with insulin-dependent diabetes mellitus (IDDM) |
DE19525784A1 (de) * | 1995-07-14 | 1997-01-16 | Boehringer Mannheim Gmbh | Autoreaktive Peptide aus der humanen Glutamin-Decarboxylase (GAD) |
US5853723A (en) * | 1995-09-21 | 1998-12-29 | University Of Utah Research Foundation | Targeting of peg antibody conjugates to islet cells |
JPH09203734A (ja) * | 1996-01-26 | 1997-08-05 | Sumitomo Electric Ind Ltd | 抗血清、抗体、リガンド及びそれらの検出方法 |
US5821334A (en) * | 1996-01-26 | 1998-10-13 | Vanderbilt University | Insulin-dependent diabetes mellitus-specific chimeric polypeptides |
US6982323B1 (en) * | 1997-12-23 | 2006-01-03 | Alexion Pharmaceuticals, Inc. | Chimeric proteins for diagnosis and treatment of diabetes |
ES2283084T3 (es) * | 1997-12-23 | 2007-10-16 | Alexion Pharmaceuticals, Inc. | Proteinas quimericas para el tratamiento de diabetes. |
JP3926626B2 (ja) * | 1999-08-18 | 2007-06-06 | キム・ホヨン | 免疫学的寛容−誘導物質 |
EP1149914B1 (de) * | 2000-04-10 | 2008-06-18 | Labor Dr. Merk und Kollegen GmbH | Fusionsprotein zur gleichzeitigen Erkennung von humanen Autoantikörpern |
GB0103024D0 (en) * | 2001-02-07 | 2001-03-21 | Rsr Ltd | Assay for Autoantibodies to tissue transglutaminase |
FI116198B (fi) * | 2001-07-16 | 2005-10-14 | Valtion Teknillinen | Polypeptidien immobilisointimenetelmä |
US20050130245A1 (en) * | 2001-09-17 | 2005-06-16 | Syn X Pharma, Inc. | Diagnosis and treatment of early pre-type-1 diabetes utilizing neuronal proteins |
GB0128583D0 (en) * | 2001-11-28 | 2002-01-23 | Rsr Ltd | Detection of autoantibodies indicative of diabetes |
AU2003226899A1 (en) * | 2002-03-20 | 2003-09-29 | Syddansk Universitet | Human diabetes-mediating proteins |
US20050004001A1 (en) * | 2002-10-02 | 2005-01-06 | Robert Harris | Formulation of antigen |
WO2005102374A2 (en) * | 2004-03-03 | 2005-11-03 | Diamyd Medical Ab | Immunomodulation by a therapeutic medication intended for treatment of diabetes and prevention of autoimmune diabetes |
US20050209138A1 (en) * | 2004-03-19 | 2005-09-22 | Diamyd Therapeutics Ab | Immunomodulation by a therapeutic medication intended for treatment of diabetes and prevention of autoimmune diabetes |
US20050250691A1 (en) * | 2004-05-10 | 2005-11-10 | Diamyd Therapeutics Ab | Immunomodulation by a therapeutic medication intended for treatment of diabetes and prevention of autoimmune diabetes |
EP2377882A1 (de) * | 2004-10-28 | 2011-10-19 | University of Pittsburgh of the Commonwealth System of Higher Education | Peripher verabreichte Gentherapie mit Glutaminsäure-Decarboxylase gegen Schmerzen aufgrund einer Rückenmarksverletzung |
WO2006098485A1 (ja) * | 2005-03-15 | 2006-09-21 | Tokyo University Of Science | グルタミン酸脱炭酸酵素変異体 |
JP5405111B2 (ja) * | 2005-09-26 | 2014-02-05 | ウルリヒ ルース | Tsh受容体及び新規tsh受容体キメラに対する自己免疫抗体検出方法 |
WO2007114959A2 (en) * | 2006-04-04 | 2007-10-11 | University Of Toledo | Altered peptide ligands of gad65 |
EP2146741A4 (de) * | 2007-04-24 | 2010-08-04 | Diamyd Therapeutics Ab | Medikamente und verfahren zur behandlung von autoimmunerkrankungen und krebs |
WO2009097425A2 (en) * | 2008-01-29 | 2009-08-06 | Spring Bioscience Corporation | Method for detecting truncated molecules |
ITMI20081249A1 (it) * | 2008-07-09 | 2010-01-09 | Novartis Vaccines & Diagnostic | Immunogeni di escherichia coli con solubilità migliorata. |
EP2836845B1 (de) | 2012-04-13 | 2018-05-09 | DiabetOmics, Inc. | Biomarker für schwangerschaftsdiabetes |
CN103788183B (zh) * | 2012-10-30 | 2016-04-13 | 苏州偲聚生物材料有限公司 | 多肽、包含该多肽的检测器件和检测试剂盒 |
CN104098667A (zh) * | 2013-04-03 | 2014-10-15 | 苏州偲聚生物材料有限公司 | 多肽、包含该多肽的检测器件和检测试剂盒 |
GB202210967D0 (en) * | 2022-07-27 | 2022-09-07 | Univ Birmingham | Tolerogenic peptides i |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU661828B2 (en) * | 1990-08-17 | 1995-08-10 | University Of Florida | Methods and compositions for early detection and treatment of insulin dependent diabetes mellitus |
ATE268908T1 (de) * | 1990-09-07 | 2004-06-15 | Univ California | Verfahren zur diagnose und behandlung von diabetes |
US5674978A (en) * | 1990-09-21 | 1997-10-07 | The Regents Of The University Of California | Peptides derived from glutamic acid decarboxylase |
US6682906B1 (en) * | 1990-09-21 | 2004-01-27 | The Regents Of The University Of California | Cloned glutamic acid decarboxylase |
US5200318A (en) * | 1992-05-13 | 1993-04-06 | Miles Inc. | Diagnosis of IDDM with a panel of immunoreagents |
ES2318847T3 (es) * | 1992-12-03 | 2009-05-01 | The Regents Of The University Of California | Metodos y reactivos mejorados para el diagnostico y el tratamiento de diabetes y del sindrome de stiff man. |
-
1993
- 1993-12-02 ES ES94905330T patent/ES2318847T3/es not_active Expired - Lifetime
- 1993-12-02 DK DK94905330T patent/DK0701569T3/da active
- 1993-12-02 WO PCT/US1993/011705 patent/WO1994012529A1/en active Application Filing
- 1993-12-02 US US08/161,290 patent/US5691448A/en not_active Expired - Lifetime
- 1993-12-02 JP JP51349794A patent/JP4242446B2/ja not_active Expired - Lifetime
- 1993-12-02 EP EP94905330A patent/EP0701569B1/de not_active Expired - Lifetime
- 1993-12-02 DE DE69334246T patent/DE69334246D1/de not_active Expired - Lifetime
-
1995
- 1995-05-25 US US08/450,755 patent/US5849506A/en not_active Expired - Lifetime
-
1997
- 1997-10-10 US US08/949,017 patent/US5998584A/en not_active Expired - Lifetime
-
2008
- 2008-11-07 JP JP2008286808A patent/JP5190698B2/ja not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
EP0701569B1 (de) | 2008-11-12 |
JPH08504406A (ja) | 1996-05-14 |
JP4242446B2 (ja) | 2009-03-25 |
US5998584A (en) | 1999-12-07 |
US5849506A (en) | 1998-12-15 |
JP2009100744A (ja) | 2009-05-14 |
EP0701569A4 (de) | 1997-08-20 |
EP0701569A1 (de) | 1996-03-20 |
JP5190698B2 (ja) | 2013-04-24 |
WO1994012529A1 (en) | 1994-06-09 |
DK0701569T3 (da) | 2009-02-23 |
ES2318847T3 (es) | 2009-05-01 |
US5691448A (en) | 1997-11-25 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition |