ATE268908T1 - Verfahren zur diagnose und behandlung von diabetes - Google Patents

Verfahren zur diagnose und behandlung von diabetes

Info

Publication number
ATE268908T1
ATE268908T1 AT91918181T AT91918181T ATE268908T1 AT E268908 T1 ATE268908 T1 AT E268908T1 AT 91918181 T AT91918181 T AT 91918181T AT 91918181 T AT91918181 T AT 91918181T AT E268908 T1 ATE268908 T1 AT E268908T1
Authority
AT
Austria
Prior art keywords
gad
assays
purified
ligand
diabetes
Prior art date
Application number
AT91918181T
Other languages
English (en)
Inventor
Steinunn Baekkeskov
Henk-Jan Aanstoot
Pietro Decamilli
Franco Folli
Michele Solimena
Original Assignee
Univ California
Univ Yale
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=24315208&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE268908(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Univ California, Univ Yale filed Critical Univ California
Application granted granted Critical
Publication of ATE268908T1 publication Critical patent/ATE268908T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/564—Immunoassay; Biospecific binding assay; Materials therefor for pre-existing immune complex or autoimmune disease, i.e. systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, rheumatoid factors or complement components C1-C9
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/573—Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/04—Endocrine or metabolic disorders
    • G01N2800/042—Disorders of carbohydrate metabolism, e.g. diabetes, glucose metabolism
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/811—Test for named disease, body condition or organ function
AT91918181T 1990-09-07 1991-09-06 Verfahren zur diagnose und behandlung von diabetes ATE268908T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US57900790A 1990-09-07 1990-09-07
PCT/US1991/006438 WO1992004632A1 (en) 1990-09-07 1991-09-06 Methods for the diagnosis and treatment of diabetes

Publications (1)

Publication Number Publication Date
ATE268908T1 true ATE268908T1 (de) 2004-06-15

Family

ID=24315208

Family Applications (1)

Application Number Title Priority Date Filing Date
AT91918181T ATE268908T1 (de) 1990-09-07 1991-09-06 Verfahren zur diagnose und behandlung von diabetes

Country Status (9)

Country Link
US (2) US7718386B1 (de)
EP (1) EP0547164B1 (de)
JP (1) JP2727377B2 (de)
AT (1) ATE268908T1 (de)
AU (1) AU8721991A (de)
DE (1) DE69133393T2 (de)
DK (1) DK0547164T3 (de)
ES (1) ES2223039T3 (de)
WO (1) WO1992004632A1 (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU727683B2 (en) * 1990-09-21 2000-12-21 Regents Of The University Of California, The Cloned glutamic acid decarboxylase
US6682906B1 (en) * 1990-09-21 2004-01-27 The Regents Of The University Of California Cloned glutamic acid decarboxylase
EP0572478B1 (de) * 1991-02-22 2005-09-07 The Walter And Eliza Hall Institute Of Medical Research Hbgad und higad polypeptide und nukleinsäuren und deren verwendung zur diagnose und behandlung von gad autoantigen assoziierten krankheiten
WO1992019972A1 (en) * 1991-05-03 1992-11-12 Novo Nordisk A/S Islet cell autoantigen (gad) for the detection of preclinical diabetes
CA2103159A1 (en) * 1991-05-15 1992-11-16 Ake Lernmark Cloning and expression of human islet glutamic acid decarboxylase autoantigen
AU661684B2 (en) * 1991-06-18 1995-08-03 Regents Of The University Of California, The Cloned glutamic acid decarboxylase
US5200318A (en) * 1992-05-13 1993-04-06 Miles Inc. Diagnosis of IDDM with a panel of immunoreagents
DE4237244A1 (de) * 1992-11-04 1994-05-05 Elias Entwicklungslabor Fuer I Verfahren zur Herstellung hochreiner humaner GAD-1- und GAD-2- Proteine
JP4242446B2 (ja) * 1992-12-03 2009-03-25 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 糖尿病及びスティフマン症候群の診断及び治療用改良試薬及び方法
EP0693183B1 (de) * 1993-04-16 2002-07-24 The Regents of the University of California Verfahren zur bestimmung der diabetesanfälligkeit bei asymptomatischen patienten
AU674584B2 (en) * 1993-06-02 1997-01-02 Tvw Telethon Institute For Child Health Research Cryptic peptides for use in inducing immunologic tolerance
DK88093D0 (da) * 1993-07-28 1993-07-28 Novo Nordisk As Stabilt praeparat
DE4418223A1 (de) 1994-05-25 1995-11-30 Boehringer Mannheim Gmbh Verfahren zum Nachweis des Vorliegens eines Insulin-abhängigen Diabetes mellitus
KR19990063648A (ko) * 1995-09-21 1999-07-26 프레드한 아룬디프 에스 글루타민산 데카복실라제에 대한 항체와 폴리(에틸렌 글리콜)공액물을 섬세포에 제공하는 방법
US5763591A (en) * 1996-03-25 1998-06-09 Cedars-Sinai Medical Center Polynucleic acid sequences that are functionally associated with the development of autoimmune disease
WO2000073800A1 (fr) * 1999-06-01 2000-12-07 Kyokuto Pharmaceutical Industrial Co., Ltd. Methode et trousse de dosage d'anticorps anti-gad
EP2366106A2 (de) * 2008-11-21 2011-09-21 Carla Perego Verfahren und zusammensetzungen zur diagnose und behandlung von diabetes
IN2014DN09410A (de) 2012-04-13 2015-07-17 Diabetomics Llc
CN114924079A (zh) * 2022-03-29 2022-08-19 北京世纪沃德生物科技有限公司 一种抗谷氨酸脱羧酶抗体测定试剂盒及检测方法

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2548963C3 (de) * 1975-11-03 1982-03-11 Merck Patent Gmbh, 6100 Darmstadt Verfahren und Mittel zur Bestimmung der Aktivität von Creatinkinase-MB
US4086142A (en) 1976-12-06 1978-04-25 The Dow Chemical Company Decarboxylation of endogenous serum glutamate in transaminase assays
DE3526096A1 (de) 1985-07-22 1987-01-22 Basf Ag Verfahren zur reinigung von htnf
US4855242A (en) 1986-04-14 1989-08-08 Joslin Diabetes Center, Inc. Method of detecting antibodies
US5258498A (en) 1987-05-21 1993-11-02 Creative Biomolecules, Inc. Polypeptide linkers for production of biosynthetic proteins
US5645998A (en) * 1988-12-13 1997-07-08 University Of Florida Research Foundation Methods and compositions for the early detection and treatment of insulin dependent diabetes mellitus
US5762937A (en) 1988-12-13 1998-06-09 University Of Florida Research Foundation, Inc. Methods and compositions for the early detection and treatment of insulin dependent diabetes mellitus
US6001360A (en) 1988-12-13 1999-12-14 University Of Florida Method and compositions for early detection and treatment of insulin dependent diabetes mellitus
WO1990007117A1 (en) 1988-12-13 1990-06-28 University Of Florida Methods and compositions for the early detection and treatment of insulin dependent diabetes mellitus
NO306996B1 (no) 1989-02-17 2000-01-24 Bayer Ag Isolert bukspyttkjerteloey-celle-(ICA)-antigen for in vitro- bruk
US5114844A (en) * 1989-03-14 1992-05-19 Yeda Research And Development Co., Ltd. Diagnosis and treatment of insulin dependent diabetes mellitus
ATE144326T1 (de) * 1990-08-17 1996-11-15 Univ Florida Verfahren und komposition zum frühnachweiss und behandlung insulinabhängiger diabetes
US5512447A (en) * 1990-09-07 1996-04-30 The Regents Of The University Of California Methods for the diagnosis and treatment of diabetes
US5998366A (en) 1990-09-21 1999-12-07 The Regents Of The University Of California Method for ameliorating glutamic acid decarboxylase associated autoimmune disorders
US5674978A (en) 1990-09-21 1997-10-07 The Regents Of The University Of California Peptides derived from glutamic acid decarboxylase
US6682906B1 (en) * 1990-09-21 2004-01-27 The Regents Of The University Of California Cloned glutamic acid decarboxylase

Also Published As

Publication number Publication date
DE69133393D1 (de) 2004-07-15
JP2727377B2 (ja) 1998-03-11
EP0547164B1 (de) 2004-06-09
JPH06502916A (ja) 1994-03-31
US20020131963A1 (en) 2002-09-19
WO1992004632A1 (en) 1992-03-19
EP0547164A4 (de) 1994-01-26
DK0547164T3 (da) 2004-10-25
US7718386B1 (en) 2010-05-18
AU8721991A (en) 1992-03-30
ES2223039T3 (es) 2005-02-16
EP0547164A1 (de) 1993-06-23
DE69133393T2 (de) 2005-06-16

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