JP6450690B2 - キメラ抗原受容体及びその使用方法 - Google Patents

キメラ抗原受容体及びその使用方法 Download PDF

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JP6450690B2
JP6450690B2 JP2015558159A JP2015558159A JP6450690B2 JP 6450690 B2 JP6450690 B2 JP 6450690B2 JP 2015558159 A JP2015558159 A JP 2015558159A JP 2015558159 A JP2015558159 A JP 2015558159A JP 6450690 B2 JP6450690 B2 JP 6450690B2
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amino acids
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JP2016508518A (ja
JP2016508518A5 (enExample
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チア−ヨン ウー
チア−ヨン ウー
ジェイムズ オウナファー
ジェイムズ オウナファー
ウェンデル エイ ． リム
ウェンデル エイ ． リム
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University of California
University of California, Los Angeles
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University of California, San Diego
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
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    • A61K40/31—Chimeric antigen receptors [CAR]
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K—PEPTIDES
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    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • C07K16/2866—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
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    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • C07K16/2878—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • C—CHEMISTRY; METALLURGY
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    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
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JP2015558159A 2013-02-15 2014-02-14 キメラ抗原受容体及びその使用方法 Active JP6450690B2 (ja)

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Application Number Priority Date Filing Date Title
US201361765585P 2013-02-15 2013-02-15
US61/765,585 2013-02-15
PCT/US2014/016527 WO2014127261A1 (en) 2013-02-15 2014-02-14 Chimeric antigen receptor and methods of use thereof

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JP2016508518A JP2016508518A (ja) 2016-03-22
JP2016508518A5 JP2016508518A5 (enExample) 2017-03-23
JP6450690B2 true JP6450690B2 (ja) 2019-01-09

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JP2018230498A Active JP6687712B2 (ja) 2013-02-15 2018-12-10 キメラ抗原受容体及びその使用方法
JP2020066759A Active JP7014843B2 (ja) 2013-02-15 2020-04-02 キメラ抗原受容体及びその使用方法
JP2022006902A Active JP7317159B2 (ja) 2013-02-15 2022-01-20 キメラ抗原受容体及びその使用方法
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JP2022006902A Active JP7317159B2 (ja) 2013-02-15 2022-01-20 キメラ抗原受容体及びその使用方法
JP2023116579A Active JP7676476B2 (ja) 2013-02-15 2023-07-18 キメラ抗原受容体及びその使用方法

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US (10) US20150368342A1 (enExample)
EP (5) EP2956175B1 (enExample)
JP (5) JP6450690B2 (enExample)
KR (5) KR20210147101A (enExample)
CN (2) CN110423282B (enExample)
AU (5) AU2014216130B2 (enExample)
CA (1) CA2901115A1 (enExample)
CY (1) CY1122386T1 (enExample)
DK (2) DK2956175T3 (enExample)
ES (3) ES2653487T3 (enExample)
HR (1) HRP20192123T1 (enExample)
HU (2) HUE036250T2 (enExample)
IL (3) IL305629A (enExample)
LT (2) LT2956175T (enExample)
MX (2) MX369545B (enExample)
NO (1) NO2929995T3 (enExample)
PL (3) PL3300745T3 (enExample)
PT (3) PT3613439T (enExample)
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Families Citing this family (354)

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WO2012088446A1 (en) 2010-12-22 2012-06-28 Board Of Trustees Of The Leland Stanford Junior University Superagonists and antagonists of interleukin-2
SG10201806573TA (en) * 2012-05-25 2018-09-27 Cellectis Methods for engineering allogeneic and immunosuppressive resistant t cell for immunotherapy
EP2934532B1 (en) 2012-12-20 2019-10-23 Purdue Research Foundation Chimeric antigen receptor-expressing t cells as anti-cancer therapeutics
SG11201505858VA (en) 2013-01-28 2015-09-29 St Jude Childrens Res Hospital A chimeric receptor with nkg2d specificity for use in cell therapy against cancer and infectious disease
IL305629A (en) 2013-02-15 2023-11-01 Univ California Chimeric antigen receptor and methods of using it
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