KR100820605B1 - 항바이러스 조성물 - Google Patents

항바이러스 조성물 Download PDF

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Publication number
KR100820605B1
KR100820605B1 KR1020077006306A KR20077006306A KR100820605B1 KR 100820605 B1 KR100820605 B1 KR 100820605B1 KR 1020077006306 A KR1020077006306 A KR 1020077006306A KR 20077006306 A KR20077006306 A KR 20077006306A KR 100820605 B1 KR100820605 B1 KR 100820605B1
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KR
South Korea
Prior art keywords
amino
benzonitrile
pyrimidinyl
formula
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
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KR1020077006306A
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English (en)
Korean (ko)
Other versions
KR20070036805A (ko
Inventor
게에르트 베르레크
리에벤 바에르트
Original Assignee
얀센 파마슈티카 엔.브이.
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Publication of KR20070036805A publication Critical patent/KR20070036805A/ko
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Plural Heterocyclic Compounds (AREA)
KR1020077006306A 1999-09-24 2000-08-31 항바이러스 조성물 Expired - Lifetime KR100820605B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP99203128.6 1999-09-24
EP99203128 1999-09-24

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
KR1020027002218A Division KR100785360B1 (ko) 1999-09-24 2000-08-31 항바이러스 조성물

Publications (2)

Publication Number Publication Date
KR20070036805A KR20070036805A (ko) 2007-04-03
KR100820605B1 true KR100820605B1 (ko) 2008-04-08

Family

ID=8240674

Family Applications (2)

Application Number Title Priority Date Filing Date
KR1020077006306A Expired - Lifetime KR100820605B1 (ko) 1999-09-24 2000-08-31 항바이러스 조성물
KR1020027002218A Expired - Lifetime KR100785360B1 (ko) 1999-09-24 2000-08-31 항바이러스 조성물

Family Applications After (1)

Application Number Title Priority Date Filing Date
KR1020027002218A Expired - Lifetime KR100785360B1 (ko) 1999-09-24 2000-08-31 항바이러스 조성물

Country Status (35)

Country Link
US (4) US7241458B1 (enExample)
EP (1) EP1225874B1 (enExample)
JP (1) JP4919566B2 (enExample)
KR (2) KR100820605B1 (enExample)
CN (1) CN1234347C (enExample)
AP (1) AP1639A (enExample)
AT (1) ATE316781T1 (enExample)
AU (2) AU775360B2 (enExample)
BG (1) BG65754B1 (enExample)
BR (1) BRPI0014271B1 (enExample)
CA (1) CA2384188C (enExample)
CY (1) CY1105268T1 (enExample)
CZ (1) CZ300712B6 (enExample)
DE (1) DE60025837T2 (enExample)
DK (1) DK1225874T3 (enExample)
EA (1) EA005423B1 (enExample)
EE (1) EE04991B1 (enExample)
ES (1) ES2258018T3 (enExample)
HK (1) HK1048768B (enExample)
HR (1) HRP20020247B1 (enExample)
HU (1) HU228449B1 (enExample)
IL (1) IL148801A0 (enExample)
IS (1) IS2567B (enExample)
MX (1) MXPA02003182A (enExample)
NO (1) NO333358B1 (enExample)
NZ (1) NZ517025A (enExample)
OA (1) OA12029A (enExample)
PL (1) PL207590B1 (enExample)
PT (1) PT1225874E (enExample)
SI (1) SI1225874T1 (enExample)
SK (1) SK285240B6 (enExample)
TR (1) TR200200763T2 (enExample)
UA (1) UA74797C2 (enExample)
WO (1) WO2001022938A1 (enExample)
ZA (1) ZA200202289B (enExample)

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