JPWO2022085680A5 - - Google Patents
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- JPWO2022085680A5 JPWO2022085680A5 JP2022557558A JP2022557558A JPWO2022085680A5 JP WO2022085680 A5 JPWO2022085680 A5 JP WO2022085680A5 JP 2022557558 A JP2022557558 A JP 2022557558A JP 2022557558 A JP2022557558 A JP 2022557558A JP WO2022085680 A5 JPWO2022085680 A5 JP WO2022085680A5
- Authority
- JP
- Japan
- Prior art keywords
- cells
- corneal endothelial
- human corneal
- less
- endothelial progenitor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 210000004027 cell Anatomy 0.000 claims 216
- 230000003511 endothelial effect Effects 0.000 claims 88
- 210000000399 corneal endothelial cell Anatomy 0.000 claims 86
- 210000000130 stem cell Anatomy 0.000 claims 86
- 238000000034 method Methods 0.000 claims 59
- 102100032912 CD44 antigen Human genes 0.000 claims 41
- 101000868273 Homo sapiens CD44 antigen Proteins 0.000 claims 41
- 238000011156 evaluation Methods 0.000 claims 27
- 239000002609 medium Substances 0.000 claims 23
- VBEQCZHXXJYVRD-GACYYNSASA-N uroanthelone Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CS)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)C(C)C)[C@@H](C)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CCSC)NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)CNC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CS)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CS)NC(=O)CNC(=O)[C@H]1N(CCC1)C(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(N)=O)C(C)C)[C@@H](C)CC)C1=CC=C(O)C=C1 VBEQCZHXXJYVRD-GACYYNSASA-N 0.000 claims 22
- 239000003112 inhibitor Substances 0.000 claims 20
- 239000011435 rock Substances 0.000 claims 20
- 238000004321 preservation Methods 0.000 claims 19
- 230000009466 transformation Effects 0.000 claims 17
- 238000013094 purity test Methods 0.000 claims 12
- 101000884271 Homo sapiens Signal transducer CD24 Proteins 0.000 claims 10
- 101000800116 Homo sapiens Thy-1 membrane glycoprotein Proteins 0.000 claims 10
- 102100038081 Signal transducer CD24 Human genes 0.000 claims 10
- 102100033523 Thy-1 membrane glycoprotein Human genes 0.000 claims 10
- 238000001943 fluorescence-activated cell sorting Methods 0.000 claims 10
- 239000001963 growth medium Substances 0.000 claims 10
- 238000010899 nucleation Methods 0.000 claims 10
- 238000012258 culturing Methods 0.000 claims 9
- 230000008569 process Effects 0.000 claims 8
- 210000000871 endothelium corneal Anatomy 0.000 claims 6
- 230000001788 irregular Effects 0.000 claims 6
- 102000004169 proteins and genes Human genes 0.000 claims 6
- 108090000623 proteins and genes Proteins 0.000 claims 6
- 230000006378 damage Effects 0.000 claims 5
- 208000027418 Wounds and injury Diseases 0.000 claims 4
- 239000012636 effector Substances 0.000 claims 4
- 208000030533 eye disease Diseases 0.000 claims 4
- 208000014674 injury Diseases 0.000 claims 4
- 230000035800 maturation Effects 0.000 claims 4
- 239000000725 suspension Substances 0.000 claims 4
- 108091006112 ATPases Proteins 0.000 claims 3
- 102000057290 Adenosine Triphosphatases Human genes 0.000 claims 3
- 230000002401 inhibitory effect Effects 0.000 claims 3
- 210000002901 mesenchymal stem cell Anatomy 0.000 claims 3
- 210000001778 pluripotent stem cell Anatomy 0.000 claims 3
- 239000011734 sodium Substances 0.000 claims 3
- 108010030844 2-methylcitrate synthase Proteins 0.000 claims 2
- 102000004146 ATP citrate synthases Human genes 0.000 claims 2
- 108090000662 ATP citrate synthases Proteins 0.000 claims 2
- 102100037768 Acetyl-CoA acetyltransferase, mitochondrial Human genes 0.000 claims 2
- 102100040958 Aconitate hydratase, mitochondrial Human genes 0.000 claims 2
- 102000004888 Aquaporin 1 Human genes 0.000 claims 2
- 108090001004 Aquaporin 1 Proteins 0.000 claims 2
- 101000678861 Arabidopsis thaliana Aconitate hydratase 1 Proteins 0.000 claims 2
- 108010081589 Becaplermin Proteins 0.000 claims 2
- 102100036376 Carbonic anhydrase 5B, mitochondrial Human genes 0.000 claims 2
- 108010071536 Citrate (Si)-synthase Proteins 0.000 claims 2
- 102000006732 Citrate synthase Human genes 0.000 claims 2
- 102100039868 Cytoplasmic aconitate hydratase Human genes 0.000 claims 2
- 238000002965 ELISA Methods 0.000 claims 2
- 102000009024 Epidermal Growth Factor Human genes 0.000 claims 2
- 101800003838 Epidermal growth factor Proteins 0.000 claims 2
- 101000598552 Homo sapiens Acetyl-CoA acetyltransferase, mitochondrial Proteins 0.000 claims 2
- 101000714497 Homo sapiens Carbonic anhydrase 5B, mitochondrial Proteins 0.000 claims 2
- 101000745370 Homo sapiens Cytoplasmic aconitate hydratase Proteins 0.000 claims 2
- 101710118630 Homocitrate dehydratase, mitochondrial Proteins 0.000 claims 2
- 102000012011 Isocitrate Dehydrogenase Human genes 0.000 claims 2
- 108010075869 Isocitrate Dehydrogenase Proteins 0.000 claims 2
- 102000003855 L-lactate dehydrogenase Human genes 0.000 claims 2
- 108700023483 L-lactate dehydrogenases Proteins 0.000 claims 2
- 101710199874 Malate dehydrogenase 1 Proteins 0.000 claims 2
- 101710199877 Malate dehydrogenase 2 Proteins 0.000 claims 2
- 102100026475 Malate dehydrogenase, cytoplasmic Human genes 0.000 claims 2
- 102100039742 Malate dehydrogenase, mitochondrial Human genes 0.000 claims 2
- 102100023175 NADP-dependent malic enzyme Human genes 0.000 claims 2
- 102100032458 NADP-dependent malic enzyme, mitochondrial Human genes 0.000 claims 2
- 101710087699 NADP-dependent malic enzyme, mitochondrial Proteins 0.000 claims 2
- 101710171478 Putative aconitate hydratase, mitochondrial Proteins 0.000 claims 2
- 108091006647 SLC9A1 Proteins 0.000 claims 2
- 102100030980 Sodium/hydrogen exchanger 1 Human genes 0.000 claims 2
- GLNADSQYFUSGOU-GPTZEZBUSA-J Trypan blue Chemical compound [Na+].[Na+].[Na+].[Na+].C1=C(S([O-])(=O)=O)C=C2C=C(S([O-])(=O)=O)C(/N=N/C3=CC=C(C=C3C)C=3C=C(C(=CC=3)\N=N\C=3C(=CC4=CC(=CC(N)=C4C=3O)S([O-])(=O)=O)S([O-])(=O)=O)C)=C(O)C2=C1N GLNADSQYFUSGOU-GPTZEZBUSA-J 0.000 claims 2
- 230000005856 abnormality Effects 0.000 claims 2
- 230000004888 barrier function Effects 0.000 claims 2
- 230000003833 cell viability Effects 0.000 claims 2
- 230000008859 change Effects 0.000 claims 2
- 238000002845 discoloration Methods 0.000 claims 2
- 230000008753 endothelial function Effects 0.000 claims 2
- 229940116977 epidermal growth factor Drugs 0.000 claims 2
- 210000002950 fibroblast Anatomy 0.000 claims 2
- 230000006870 function Effects 0.000 claims 2
- 238000003384 imaging method Methods 0.000 claims 2
- 108090000286 malate dehydrogenase (decarboxylating) Proteins 0.000 claims 2
- 238000002360 preparation method Methods 0.000 claims 2
- 238000010186 staining Methods 0.000 claims 2
- 239000006228 supernatant Substances 0.000 claims 2
- 108010046716 3-Methyl-2-Oxobutanoate Dehydrogenase (Lipoamide) Proteins 0.000 claims 1
- 102100028704 Acetyl-CoA acetyltransferase, cytosolic Human genes 0.000 claims 1
- 102100030381 Acetyl-coenzyme A synthetase 2-like, mitochondrial Human genes 0.000 claims 1
- 102100035709 Acetyl-coenzyme A synthetase, cytoplasmic Human genes 0.000 claims 1
- 102100026413 Branched-chain-amino-acid aminotransferase, mitochondrial Human genes 0.000 claims 1
- 208000028006 Corneal injury Diseases 0.000 claims 1
- 101710088194 Dehydrogenase Proteins 0.000 claims 1
- 102000004190 Enzymes Human genes 0.000 claims 1
- 108090000790 Enzymes Proteins 0.000 claims 1
- 101000837584 Homo sapiens Acetyl-CoA acetyltransferase, cytosolic Proteins 0.000 claims 1
- 101000773358 Homo sapiens Acetyl-coenzyme A synthetase 2-like, mitochondrial Proteins 0.000 claims 1
- 101000783232 Homo sapiens Acetyl-coenzyme A synthetase, cytoplasmic Proteins 0.000 claims 1
- 101000766294 Homo sapiens Branched-chain-amino-acid aminotransferase, mitochondrial Proteins 0.000 claims 1
- 101000617830 Homo sapiens Sterol O-acyltransferase 1 Proteins 0.000 claims 1
- LCTONWCANYUPML-UHFFFAOYSA-M Pyruvate Chemical compound CC(=O)C([O-])=O LCTONWCANYUPML-UHFFFAOYSA-M 0.000 claims 1
- -1 ZO-1 Proteins 0.000 claims 1
- 230000010307 cell transformation Effects 0.000 claims 1
- 210000004087 cornea Anatomy 0.000 claims 1
- 208000021921 corneal disease Diseases 0.000 claims 1
- 230000004069 differentiation Effects 0.000 claims 1
- 210000002889 endothelial cell Anatomy 0.000 claims 1
- 230000001747 exhibiting effect Effects 0.000 claims 1
- 230000002503 metabolic effect Effects 0.000 claims 1
- 239000000825 pharmaceutical preparation Substances 0.000 claims 1
- 229940127557 pharmaceutical product Drugs 0.000 claims 1
- 230000002062 proliferating effect Effects 0.000 claims 1
- 229910052708 sodium Inorganic materials 0.000 claims 1
- 230000007704 transition Effects 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023119210A JP2023139164A (ja) | 2020-10-22 | 2023-07-21 | ヒト角膜内皮細胞及び／又はヒト角膜内皮前駆細胞の保存方法 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2020177634 | 2020-10-22 | ||
| JP2020177634 | 2020-10-22 | ||
| PCT/JP2021/038609 WO2022085680A1 (ja) | 2020-10-22 | 2021-10-19 | ヒト角膜内皮細胞及び／又はヒト角膜内皮前駆細胞の保存方法 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023119210A Division JP2023139164A (ja) | 2020-10-22 | 2023-07-21 | ヒト角膜内皮細胞及び／又はヒト角膜内皮前駆細胞の保存方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JPWO2022085680A1 JPWO2022085680A1 (https=) | 2022-04-28 |
| JPWO2022085680A5 true JPWO2022085680A5 (https=) | 2023-04-17 |
| JP7361431B2 JP7361431B2 (ja) | 2023-10-16 |
Family
ID=81290627
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022557558A Active JP7361431B2 (ja) | 2020-10-22 | 2021-10-19 | ヒト角膜内皮細胞及び／又はヒト角膜内皮前駆細胞の保存方法 |
| JP2023119210A Pending JP2023139164A (ja) | 2020-10-22 | 2023-07-21 | ヒト角膜内皮細胞及び／又はヒト角膜内皮前駆細胞の保存方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023119210A Pending JP2023139164A (ja) | 2020-10-22 | 2023-07-21 | ヒト角膜内皮細胞及び／又はヒト角膜内皮前駆細胞の保存方法 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US12550891B2 (https=) |
| EP (1) | EP4234682A4 (https=) |
| JP (2) | JP7361431B2 (https=) |
| KR (1) | KR20230091107A (https=) |
| CN (1) | CN116583593A (https=) |
| AU (2) | AU2021366805B2 (https=) |
| CA (1) | CA3196110A1 (https=) |
| IL (1) | IL302168A (https=) |
| MX (2) | MX2023004594A (https=) |
| WO (1) | WO2022085680A1 (https=) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2025145016A1 (en) * | 2023-12-29 | 2025-07-03 | Aurion Biotech, Inc. | Corneal endothelial cell (cec) culturing methods and compositions |
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-
2021
- 2021-10-19 AU AU2021366805A patent/AU2021366805B2/en active Active
- 2021-10-19 MX MX2023004594A patent/MX2023004594A/es unknown
- 2021-10-19 CN CN202180072227.5A patent/CN116583593A/zh active Pending
- 2021-10-19 IL IL302168A patent/IL302168A/en unknown
- 2021-10-19 US US18/032,726 patent/US12550891B2/en active Active
- 2021-10-19 EP EP21882821.8A patent/EP4234682A4/en active Pending
- 2021-10-19 KR KR1020237014236A patent/KR20230091107A/ko active Pending
- 2021-10-19 JP JP2022557558A patent/JP7361431B2/ja active Active
- 2021-10-19 WO PCT/JP2021/038609 patent/WO2022085680A1/ja not_active Ceased
- 2021-10-19 CA CA3196110A patent/CA3196110A1/en active Pending
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2023
- 2023-04-20 MX MX2025003724A patent/MX2025003724A/es unknown
- 2023-07-21 JP JP2023119210A patent/JP2023139164A/ja active Pending
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2025
- 2025-07-21 AU AU2025206385A patent/AU2025206385A1/en active Pending
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