JP2023139164A5 - - Google Patents

Info

Publication number

JP2023139164A5

JP2023139164A5 JP2023119210A JP2023119210A JP2023139164A5 JP 2023139164 A5 JP2023139164 A5 JP 2023139164A5 JP 2023119210 A JP2023119210 A JP 2023119210A JP 2023119210 A JP2023119210 A JP 2023119210A JP 2023139164 A5 JP2023139164 A5 JP 2023139164A5

Authority

JP

Japan

Prior art keywords

cells

corneal endothelial

human corneal

less

days

Prior art date

2023-07-21

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
• Global Dossier
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• 210000004027 cell Anatomy 0.000 claims 178
• 210000000399 corneal endothelial cell Anatomy 0.000 claims 52
• 230000003511 endothelial effect Effects 0.000 claims 52
• 239000002243 precursor Substances 0.000 claims 52
• 102100032912 CD44 antigen Human genes 0.000 claims 24
• 101000868273 Homo sapiens CD44 antigen Proteins 0.000 claims 24
• 238000011156 evaluation Methods 0.000 claims 20
• 239000002609 medium Substances 0.000 claims 17
• 238000000034 method Methods 0.000 claims 16
• VBEQCZHXXJYVRD-GACYYNSASA-N uroanthelone Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CS)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)C(C)C)[C@@H](C)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CCSC)NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)CNC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CS)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CS)NC(=O)CNC(=O)[C@H]1N(CCC1)C(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(N)=O)C(C)C)[C@@H](C)CC)C1=CC=C(O)C=C1 VBEQCZHXXJYVRD-GACYYNSASA-N 0.000 claims 14
• 239000003112 inhibitor Substances 0.000 claims 11
• 239000011435 rock Substances 0.000 claims 11
• 230000009466 transformation Effects 0.000 claims 8
• 238000012258 culturing Methods 0.000 claims 6
• 101000884271 Homo sapiens Signal transducer CD24 Proteins 0.000 claims 5
• 101000800116 Homo sapiens Thy-1 membrane glycoprotein Proteins 0.000 claims 5
• 102100038081 Signal transducer CD24 Human genes 0.000 claims 5
• 102100033523 Thy-1 membrane glycoprotein Human genes 0.000 claims 5
• 238000001943 fluorescence-activated cell sorting Methods 0.000 claims 5
• 238000013094 purity test Methods 0.000 claims 5
• 239000001963 growth medium Substances 0.000 claims 4
• 230000001788 irregular Effects 0.000 claims 4
• 102000009024 Epidermal Growth Factor Human genes 0.000 claims 3
• 101800003838 Epidermal growth factor Proteins 0.000 claims 3
• 229940116977 epidermal growth factor Drugs 0.000 claims 3
• 238000003306 harvesting Methods 0.000 claims 2
• 238000004321 preservation Methods 0.000 claims 2
• 230000002062 proliferating effect Effects 0.000 claims 2
• 239000000725 suspension Substances 0.000 claims 2