MX2023004594A - Un metodo de almacenamiento de celulas endoteliales de la cornea humanas y/o celulas precursoras endoteliales de la cornea humanas. - Google Patents
Un metodo de almacenamiento de celulas endoteliales de la cornea humanas y/o celulas precursoras endoteliales de la cornea humanas.Info
- Publication number
- MX2023004594A MX2023004594A MX2023004594A MX2023004594A MX2023004594A MX 2023004594 A MX2023004594 A MX 2023004594A MX 2023004594 A MX2023004594 A MX 2023004594A MX 2023004594 A MX2023004594 A MX 2023004594A MX 2023004594 A MX2023004594 A MX 2023004594A
- Authority
- MX
- Mexico
- Prior art keywords
- cells
- corneal endothelial
- human corneal
- time
- sup
- Prior art date
Links
- 210000000399 corneal endothelial cell Anatomy 0.000 title abstract 6
- 230000003511 endothelial effect Effects 0.000 title abstract 6
- 210000000130 stem cell Anatomy 0.000 title abstract 6
- 238000004321 preservation Methods 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 2
- 210000004027 cell Anatomy 0.000 abstract 7
- 102100032912 CD44 antigen Human genes 0.000 abstract 2
- 101000868273 Homo sapiens CD44 antigen Proteins 0.000 abstract 2
- 239000001963 growth medium Substances 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 230000004660 morphological change Effects 0.000 abstract 1
- 239000011435 rock Substances 0.000 abstract 1
- 230000004083 survival effect Effects 0.000 abstract 1
- 230000009466 transformation Effects 0.000 abstract 1
- VBEQCZHXXJYVRD-GACYYNSASA-N uroanthelone Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CS)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)C(C)C)[C@@H](C)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CCSC)NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)CNC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CS)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CS)NC(=O)CNC(=O)[C@H]1N(CCC1)C(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(N)=O)C(C)C)[C@@H](C)CC)C1=CC=C(O)C=C1 VBEQCZHXXJYVRD-GACYYNSASA-N 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
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- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0618—Cells of the nervous system
- C12N5/0621—Eye cells, e.g. cornea, iris pigmented cells
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/02—Preservation of living parts
- A01N1/0278—Physical preservation processes
- A01N1/0284—Temperature processes, i.e. using a designated change in temperature over time
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/02—Preservation of living parts
- A01N1/0205—Chemical aspects
- A01N1/021—Preservation or perfusion media, liquids, solids or gases used in the preservation of cells, tissue, organs or bodily fluids
- A01N1/0226—Physiologically active agents, i.e. substances affecting physiological processes of cells and tissue to be preserved, e.g. anti-oxidants or nutrients
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/04—Preserving or maintaining viable microorganisms
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/02—Preservation of living parts
- A01N1/0205—Chemical aspects
- A01N1/021—Preservation or perfusion media, liquids, solids or gases used in the preservation of cells, tissue, organs or bodily fluids
- A01N1/0221—Freeze-process protecting agents, i.e. substances protecting cells from effects of the physical process, e.g. cryoprotectants, osmolarity regulators like oncotic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/30—Nerves; Brain; Eyes; Corneal cells; Cerebrospinal fluid; Neuronal stem cells; Neuronal precursor cells; Glial cells; Oligodendrocytes; Schwann cells; Astroglia; Astrocytes; Choroid plexus; Spinal cord tissue
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/48—Reproductive organs
- A61K35/54—Ovaries; Ova; Ovules; Embryos; Foetal cells; Germ cells
- A61K35/545—Embryonic stem cells; Pluripotent stem cells; Induced pluripotent stem cells; Uncharacterised stem cells
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/11—Epidermal growth factor [EGF]
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/70—Enzymes
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
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- C12N2501/727—Kinases (EC 2.7.)
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- C12N2533/00—Supports or coatings for cell culture, characterised by material
- C12N2533/50—Proteins
- C12N2533/54—Collagen; Gelatin
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- Chemical & Material Sciences (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Cell Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Developmental Biology & Embryology (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Virology (AREA)
- Ophthalmology & Optometry (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Dentistry (AREA)
- Environmental Sciences (AREA)
- Immunology (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Biophysics (AREA)
- Physiology (AREA)
- Reproductive Health (AREA)
- Tropical Medicine & Parasitology (AREA)
- Gynecology & Obstetrics (AREA)
- Hematology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Materials For Medical Uses (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Chemical Kinetics & Catalysis (AREA)
Abstract
Las células endoteliales de la córnea humana y/o las células precursoras endoteliales de la córnea humana se conservan con una alta tasa de supervivencia de estas células manteniéndose, y se suprime la tasa de aparición de células contaminadas en el cultivo posterior a la conservación. Un método de almacenamiento de células endoteliales de la córnea humana y/o células precursoras endoteliales de la córnea humana se caracteriza porque las células endoteliales de la córnea humana y/o las células precursoras endoteliales de la córnea humana que han sido cultivadas utilizando un medio de cultivo que contiene un inhibidor de ROCK, y en el que el contenido de factor de crecimiento epidérmico (EGF) es menor que una concentración que causará una transformación se recolectan en un tiempo en que se cumple cualquiera de o una pluralidad de las condiciones (a) ~ (d) que se indican a continuación, y se colocan en un estado de suspensión y luego de conservado. (a) Durante un período inmediatamente después de que una morfología de las células endoteliales de la córnea humana y/o de las células precursoras endoteliales de la córnea humana haya cambiado de una forma fusiforme a una forma poligonal o una forma elíptica cuya proporción eje mayor-eje menor es cercana a 1, hasta inmediatamente antes de que los límites entre las células se vuelvan indistintos. (b) Durante un período desde que un nivel de expresión de CD44 se vuelve igual o inferior a la mitad del valor máximo observado después del subcultivo más reciente hasta que este nivel de expresión alcanza una meseta. (c) Cuando la densidad celular de las células endoteliales de la córnea humana y/o de las células precursoras endoteliales de la córnea humana no sea inferior a 900 células/mm2 ni superior a 2500 células/mm2. (d) Cuando el número de días de cultivo desde el subcultivo más reciente no sea inferior a 4 días ni superior a 14 días.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2020177634 | 2020-10-22 | ||
PCT/JP2021/038609 WO2022085680A1 (ja) | 2020-10-22 | 2021-10-19 | ヒト角膜内皮細胞及び/又はヒト角膜内皮前駆細胞の保存方法 |
Publications (1)
Publication Number | Publication Date |
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MX2023004594A true MX2023004594A (es) | 2023-05-08 |
Family
ID=81290627
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2023004594A MX2023004594A (es) | 2020-10-22 | 2021-10-19 | Un metodo de almacenamiento de celulas endoteliales de la cornea humanas y/o celulas precursoras endoteliales de la cornea humanas. |
Country Status (10)
Country | Link |
---|---|
US (1) | US20230380417A1 (es) |
EP (1) | EP4234682A1 (es) |
JP (2) | JP7361431B2 (es) |
KR (1) | KR20230091107A (es) |
CN (1) | CN116583593A (es) |
AU (1) | AU2021366805A1 (es) |
CA (1) | CA3196110A1 (es) |
IL (1) | IL302168A (es) |
MX (1) | MX2023004594A (es) |
WO (1) | WO2022085680A1 (es) |
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2021
- 2021-10-19 MX MX2023004594A patent/MX2023004594A/es unknown
- 2021-10-19 WO PCT/JP2021/038609 patent/WO2022085680A1/ja active Application Filing
- 2021-10-19 KR KR1020237014236A patent/KR20230091107A/ko unknown
- 2021-10-19 US US18/032,726 patent/US20230380417A1/en active Pending
- 2021-10-19 CN CN202180072227.5A patent/CN116583593A/zh active Pending
- 2021-10-19 AU AU2021366805A patent/AU2021366805A1/en active Pending
- 2021-10-19 IL IL302168A patent/IL302168A/en unknown
- 2021-10-19 JP JP2022557558A patent/JP7361431B2/ja active Active
- 2021-10-19 CA CA3196110A patent/CA3196110A1/en active Pending
- 2021-10-19 EP EP21882821.8A patent/EP4234682A1/en active Pending
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2023
- 2023-07-21 JP JP2023119210A patent/JP2023139164A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
US20230380417A1 (en) | 2023-11-30 |
CA3196110A1 (en) | 2022-04-28 |
WO2022085680A1 (ja) | 2022-04-28 |
IL302168A (en) | 2023-06-01 |
EP4234682A1 (en) | 2023-08-30 |
CN116583593A (zh) | 2023-08-11 |
JP7361431B2 (ja) | 2023-10-16 |
JPWO2022085680A1 (es) | 2022-04-28 |
JP2023139164A (ja) | 2023-10-03 |
AU2021366805A1 (en) | 2023-06-22 |
KR20230091107A (ko) | 2023-06-22 |
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