CA3196110A1 - A storage method of human corneal endothelial cells and/or human corneal endothelial precursor cells - Google Patents

A storage method of human corneal endothelial cells and/or human corneal endothelial precursor cells

Info

Publication number
CA3196110A1
CA3196110A1 CA3196110A CA3196110A CA3196110A1 CA 3196110 A1 CA3196110 A1 CA 3196110A1 CA 3196110 A CA3196110 A CA 3196110A CA 3196110 A CA3196110 A CA 3196110A CA 3196110 A1 CA3196110 A1 CA 3196110A1
Authority
CA
Canada
Prior art keywords
cells
corneal endothelial
human corneal
less
days
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3196110A
Other languages
English (en)
French (fr)
Inventor
Shigeru Kinoshita
Munetoyo Toda
Chie Sotozono
Morio Ueno
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kyoto Prefectural PUC
Original Assignee
Kyoto Prefectural PUC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyoto Prefectural PUC filed Critical Kyoto Prefectural PUC
Publication of CA3196110A1 publication Critical patent/CA3196110A1/en
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0618—Cells of the nervous system
    • C12N5/0621—Eye cells, e.g. cornea, iris pigmented cells
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/10—Preservation of living parts
    • A01N1/12—Chemical aspects of preservation
    • A01N1/122—Preservation or perfusion media
    • A01N1/126—Physiologically active agents, e.g. antioxidants or nutrients
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/10—Preservation of living parts
    • A01N1/12—Chemical aspects of preservation
    • A01N1/122—Preservation or perfusion media
    • A01N1/125—Freeze protecting agents, e.g. cryoprotectants or osmolarity regulators
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/10—Preservation of living parts
    • A01N1/16—Physical preservation processes
    • A01N1/162—Temperature processes, e.g. following predefined temperature changes over time
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/48—Reproductive organs
    • A61K35/54—Ovaries; Ova; Ovules; Embryos; Foetal cells; Germ cells
    • A61K35/545—Embryonic stem cells; Pluripotent stem cells; Induced pluripotent stem cells; Uncharacterised stem cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/04—Preserving or maintaining viable microorganisms
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/30—Nerves; Brain; Eyes; Corneal cells; Cerebrospinal fluid; Neuronal stem cells; Neuronal precursor cells; Glial cells; Oligodendrocytes; Schwann cells; Astroglia; Astrocytes; Choroid plexus; Spinal cord tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/11—Epidermal growth factor [EGF]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/70—Enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/70—Enzymes
    • C12N2501/72—Transferases [EC 2.]
    • C12N2501/727—Kinases (EC 2.7.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/50—Proteins
    • C12N2533/54—Collagen; Gelatin

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Developmental Biology & Embryology (AREA)
  • Medicinal Chemistry (AREA)
  • Virology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Ophthalmology & Optometry (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Immunology (AREA)
  • Environmental Sciences (AREA)
  • Dentistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Reproductive Health (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Hematology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Materials For Medical Uses (AREA)
  • Biophysics (AREA)
  • Physiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
CA3196110A 2020-10-22 2021-10-19 A storage method of human corneal endothelial cells and/or human corneal endothelial precursor cells Pending CA3196110A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2020-177634 2020-10-22
JP2020177634 2020-10-22
PCT/JP2021/038609 WO2022085680A1 (ja) 2020-10-22 2021-10-19 ヒト角膜内皮細胞及び／又はヒト角膜内皮前駆細胞の保存方法

Publications (1)

Publication Number Publication Date
CA3196110A1 true CA3196110A1 (en) 2022-04-28

Family

ID=81290627

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3196110A Pending CA3196110A1 (en) 2020-10-22 2021-10-19 A storage method of human corneal endothelial cells and/or human corneal endothelial precursor cells

Country Status (10)

Country Link
US (1) US12550891B2 (https=)
EP (1) EP4234682A4 (https=)
JP (2) JP7361431B2 (https=)
KR (1) KR20230091107A (https=)
CN (1) CN116583593A (https=)
AU (2) AU2021366805B2 (https=)
CA (1) CA3196110A1 (https=)
IL (1) IL302168A (https=)
MX (2) MX2023004594A (https=)
WO (1) WO2022085680A1 (https=)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2025145016A1 (en) * 2023-12-29 2025-07-03 Aurion Biotech, Inc. Corneal endothelial cell (cec) culturing methods and compositions

Family Cites Families (61)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4678783B1 (en) 1983-11-04 1995-04-04 Asahi Chemical Ind Substituted isoquinolinesulfonyl compounds
JPH0276976A (ja) 1988-09-12 1990-03-16 Matsushita Electric Ind Co Ltd 制御弁
JPH0276977A (ja) 1988-09-12 1990-03-16 Matsushita Electric Ind Co Ltd 湯水混合装置
JPH02100833A (ja) 1988-10-07 1990-04-12 Tokai T R W Kk 転造ダイスの加工方法
JPH0359913A (ja) 1989-07-28 1991-03-14 Yazaki Corp 金属溶射による回路体の製造方法
JPH0362227A (ja) 1989-07-31 1991-03-18 Nec Corp 高速再翻訳処理方式
JPH04620A (ja) 1990-04-18 1992-01-06 Nec Off Syst Ltd キーボード
EP1195372A1 (en) 1994-04-18 2002-04-10 Mitsubishi Pharma Corporation N-heterocyclic substituted benzamide derivatives with antihypertensive activity
JPH081403A (ja) 1994-06-22 1996-01-09 Fukui Seisakusho:Kk Ｎｃ装置付き工作機械によるネジ端部バリ取り方法
JP3906284B2 (ja) 1995-04-14 2007-04-18 株式会社東芝 光ディスクからビデオ及びオーディオを再生する再生システム、その再生方法及び光ディスクの記録方法
JP3421217B2 (ja) 1995-11-20 2003-06-30 麒麟麦酒株式会社 Ｒｈｏ標的タンパク質Ｒｈｏキナーゼ
AU9646198A (en) 1997-10-22 1999-05-10 Nippon Shinyaku Co. Ltd. Isoquinoline derivative and drug
WO1999061403A1 (en) 1998-05-25 1999-12-02 Santen Pharmaceutical Co., Ltd. Novel vinylbenzene derivatives
JP4315407B2 (ja) 2000-09-07 2009-08-19 コスモ石油株式会社 競合見積管理システムおよび方法、並びに購買ウエブサーバ
PE20020958A1 (es) 2001-03-23 2002-11-14 Bayer Corp Inhibidores de la rho-quinasa
UY27224A1 (es) 2001-03-23 2002-10-31 Bayer Corp Inhibidores de la rho-quinasa
US7109208B2 (en) 2001-04-11 2006-09-19 Senju Pharmaceutical Co., Ltd. Visual function disorder improving agents
WO2002100833A1 (en) 2001-06-12 2002-12-19 Sumitomo Pharmaceuticals Company, Limited Rho KINASE INHIBITORS
JP4505228B2 (ja) 2002-01-10 2010-07-21 バイエル・シェーリング・ファルマ・アクチェンゲゼルシャフト Ｒｈｏ−キナーゼ阻害剤
MXPA04007196A (es) 2002-01-23 2005-06-08 Bayer Pharmaceuticals Corp Inhibidores de rho-quinasa.
JP2004009555A (ja) 2002-06-07 2004-01-15 Futec Inc 印刷欠点の検出装置および検出方法
US6911772B2 (en) 2002-06-12 2005-06-28 Eastman Kodak Company Oled display having color filters for improving contrast
EP1541559A4 (en) 2002-07-22 2007-08-22 Asahi Kasei Pharma Corp 5-SUBSTITUTED ISOQUINOLINE DERIVATIVE
CA2400996A1 (en) 2002-09-03 2004-03-03 Lisa Mckerracher 1,4-substituted cyclohexane derivatives
JP4023271B2 (ja) 2002-09-20 2007-12-19 株式会社トヨトミ 窓用空気調和機の構造
US7160894B2 (en) 2003-06-06 2007-01-09 Asahi Kasei Pharma Corporation Tricyclic compound
JP2005003101A (ja) 2003-06-12 2005-01-06 Toyota Motor Corp 無段変速機の制御装置
WO2005003101A2 (en) 2003-07-02 2005-01-13 Biofocus Discovery Limited Pyrazine and pyridine derivatives as rho kinase inhibitors
JP2005035501A (ja) 2003-07-14 2005-02-10 Takahisa Tsutsui 油タンカー船の積付け計算をボタン操作によって調整かつ、連動して海面を表示するプログラム
JP2005035503A (ja) 2003-07-15 2005-02-10 Okubo Tomio 自転車等の防寒用ハンドルカバー
JP2005039564A (ja) 2003-07-16 2005-02-10 Nec Saitama Ltd 画像配信システム、サーバ装置、携帯端末装置及びそれに用いる画像配信方法
JP2005035506A (ja) 2003-07-17 2005-02-10 Masuo Kato パイプを使用した水上、水中液体貯蔵装置及び水上輸送方法
JP4160460B2 (ja) 2003-07-18 2008-10-01 ヤマザキマザック株式会社 レーザ加工機
JP2005037198A (ja) 2003-07-18 2005-02-10 Kawasaki Heavy Ind Ltd 内側炉心槽の挿入・引き抜き方法及びその装置と内側炉心槽引き抜き時の燃料集合体の拘束支持方法及びその装置
JP2005037197A (ja) 2003-07-18 2005-02-10 Ricoh Co Ltd 接触式表面形状測定装置及び測定方法
JP3759133B2 (ja) 2003-08-29 2006-03-22 ローム株式会社 電源装置
JP4315279B2 (ja) 2003-09-30 2009-08-19 能美防災株式会社 消防用設備の開閉弁装置及びその制御弁
WO2005039564A1 (en) 2003-10-02 2005-05-06 Vertex Pharmaceuticals Incorporated Phthalimide compounds useful as protein kinase inhibitors
ES2387780T3 (es) 2003-10-06 2012-10-01 Glaxosmithkline Llc Preparación de azabencimidazoles 1,6-disustituidos como inhibidores de quinasas
JP2007507547A (ja) 2003-10-06 2007-03-29 グラクソ　グループ　リミテッド キナーゼ阻害剤としての１，７−二置換アザベンゾイミダゾールの調製
WO2005034866A2 (en) 2003-10-06 2005-04-21 Glaxo Group Limited Preparation of 1, 6, 7- trisubstituted azabenzimidazoles as kinase inhibitors
CN1898377A (zh) * 2003-10-10 2007-01-17 细胞生物工程公司 人角膜内皮细胞以及获得和培养用于角膜细胞移植的细胞的方法
JP2007015928A (ja) 2003-10-15 2007-01-25 Ube Ind Ltd 新規オレフィン誘導体
EP1679308B1 (en) 2003-10-15 2013-07-24 Ube Industries, Ltd. Novel indazole derivative
JP2007008816A (ja) 2003-10-15 2007-01-18 Ube Ind Ltd 新規イソキノリン誘導体
CA2556589A1 (en) 2004-02-24 2005-09-01 Bioaxone Therapeutique Inc. 4-substituted piperidine derivatives
AR049333A1 (es) 2004-04-02 2006-07-19 Vertex Pharma Azaindoles inhibidores de proteinquinasas rock y otras proteinas quinasas. composiciones farmaceuticas.
JP2006057270A (ja) 2004-08-18 2006-03-02 Akimori Taniguchi 巨大水母類の漂着による、取水口スクリ−ン吸着閉塞防止システム。
US20060101035A1 (en) 2004-11-11 2006-05-11 Mustakallio Minna M System and method for blog functionality
WO2006057270A1 (ja) 2004-11-26 2006-06-01 Asahi Kasei Pharma Corporation 含窒素３環化合物
CA2621181C (en) 2005-08-30 2011-04-19 Asahi Kasei Pharma Corporation 5-isoquinolinesulfonamide compounds
WO2009028631A1 (ja) 2007-08-29 2009-03-05 Senju Pharmaceutical Co., Ltd. 角膜内皮細胞接着促進剤
US10174284B2 (en) * 2012-09-07 2019-01-08 Jcr Pharmaceuticals Co., Ltd. Medium, for culturing corneal endothelial cells, containing conditioned medium from mesenchymal stem cells
JP6637656B2 (ja) * 2014-01-16 2020-01-29 千寿製薬株式会社 角膜内皮細胞を含有する移植用組成物
WO2016128074A1 (de) 2015-02-13 2016-08-18 P + L Gmbh & Co. Kg Verfahren zur lagebestimmung eines werkstücks in einer werkzeugmaschine
WO2017110094A1 (ja) 2015-12-24 2017-06-29 学校法人同志社 カスパーゼ阻害剤を含む、ＴＧＦ－βに起因する障害を治療または予防するための医薬およびその応用
EP3416658B1 (en) * 2016-02-15 2023-03-22 Kyoto Prefectural Public University Corporation Human functional corneal endothelial cell and application thereof
US20210195539A1 (en) 2018-08-09 2021-06-24 Sharp Kabushiki Kaisha Integrated access and backhaul node recognition in integrated access and backhaul network
JP2020032139A (ja) 2018-08-31 2020-03-05 株式会社三洋物産 遊技機
US20210207088A1 (en) * 2018-08-31 2021-07-08 The Doshisha Composition and method for preserving or culturing ocular cells
WO2021172554A1 (ja) 2020-02-27 2021-09-02 京都府公立大学法人 ヒト機能性角膜内皮細胞およびその応用

Also Published As

Publication number Publication date
AU2021366805B2 (en) 2025-04-24
JPWO2022085680A1 (https=) 2022-04-28
US20230380417A1 (en) 2023-11-30
US12550891B2 (en) 2026-02-17
AU2021366805A1 (en) 2023-06-22
JP2023139164A (ja) 2023-10-03
JP7361431B2 (ja) 2023-10-16
CN116583593A (zh) 2023-08-11
IL302168A (en) 2023-06-01
WO2022085680A1 (ja) 2022-04-28
AU2025206385A1 (en) 2025-08-07
MX2025003724A (es) 2025-05-02
EP4234682A4 (en) 2024-11-27
KR20230091107A (ko) 2023-06-22
MX2023004594A (es) 2023-05-08
EP4234682A1 (en) 2023-08-30
NZ799955A (en) 2025-05-30

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