JPH11501691A - グルカンの製造方法、及びグルカンの治療用途 - Google Patents
グルカンの製造方法、及びグルカンの治療用途Info
- Publication number
- JPH11501691A JPH11501691A JP8527114A JP52711496A JPH11501691A JP H11501691 A JPH11501691 A JP H11501691A JP 8527114 A JP8527114 A JP 8527114A JP 52711496 A JP52711496 A JP 52711496A JP H11501691 A JPH11501691 A JP H11501691A
- Authority
- JP
- Japan
- Prior art keywords
- glucan
- treatment
- soluble
- acid
- skin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/716—Glucans
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
- A61L26/0023—Polysaccharides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/16—Emollients or protectives, e.g. against radiation
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/004—Aftersun preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
- C08B37/0024—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid beta-D-Glucans; (beta-1,3)-D-Glucans, e.g. paramylon, coriolan, sclerotan, pachyman, callose, scleroglucan, schizophyllan, laminaran, lentinan or curdlan; (beta-1,6)-D-Glucans, e.g. pustulan; (beta-1,4)-D-Glucans; (beta-1,3)(beta-1,4)-D-Glucans, e.g. lichenan; Derivatives thereof
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/04—Polysaccharides, i.e. compounds containing more than five saccharide radicals attached to each other by glycosidic bonds
Abstract
Description
Claims (1)
- 【特許請求の範囲】 1.以下のステップよりなるグルカン含有細胞源からのβ−(1,3)(1,6 )−グルカンの製造方法: (a)グルカン含有細胞をアルカリ可溶性成分を除去するために、アルカリ及び 加熱して抽出し、 (b)ステップ(a)の細胞を酸と加熱して酸抽出して懸濁液を形成させ、 (c)ステップ(b)で得られた縣濁液、若しくは加水分解され、回収された細 胞体を、水と混ざらず、かつ、水よりも密度の高い有機溶媒で抽出し、水に縣濁 しているβ−(1,3)(1,6)グルカン微粒子物質を含有する水層のみが実 質的に残るように、できた水層、溶媒含有層、界面を分離し、該有機溶媒での抽 出では分岐したβ−(1,3)(1,6)グルカンと、残渣の非グルカンコンタ ミと会合している実質的に非分岐のβ−(1,3)グルカンからなるグルカンサ ブグループとの分離をさせる、 (d)ステップ(c)からのグルカン物質を乾燥し微粒子グルカンを得る。 2.可溶性グルカンを製造する方法でステップ(d)が省略されグルカン物質の pHをグルカンを可溶化できるように上昇させ、反応温度が約60℃以下である 、請求項1記載の方法。 3.可溶性グルカンを製造する方法であって、ステップ(d)のグルカン粒子を グルカンを可溶化させるためにアルカリ水溶液に懸濁させ、反応温度が約60℃ 以下である、請求項1記載の方法。 4.反応温度が約2℃から約8℃の間で、可溶性グルカンが医薬品としての用途 に適切な多分散指数を有する請求項2、若しくは3記載の方法。 5.ステップ(d)で使用する酸が酢酸、蟻酸、リン酸及び塩酸から選択される 請求項1記載の方法。 6.ステップ(b)の酸のpHが約2から約6である請求項1記載の方法。 7.ステップ(c)の有機溶媒がクロロフォルム、メチルクロロフォルム、ジク ロロメタン、テトラクロロエタン及び4塩化炭素から選択される請求項1記載の 方法。 8.該溶媒がクロロフォルムである請求項7記載の方法。 9.グルカン溶解後溶液のpHがpH約9とpH約10の範囲に調整され、結果 としてできる可溶性のグルカンが一以上の薬理学的に許容できる担体、若しくは 賦形剤と混合される請求項2または3記載の方法。 10.グルカン溶解後溶液のpHが、一以上の薬理学的に許容できる担体、若し くは賦形剤と任意に混合されるゲルが形成されるようにpH約7とpH約8の範 囲に調整される請求項2、若しくは3記載の方法。 11.任意に薬理学的に許容できる担体、若しくは賦形剤と結合して、請求項1 記載の方法で製造されるグルカン粒子。 12.任意に薬理学的に許容できる担体、若しくは賦形剤と結合して、請求項2 、若しくは4記載のいずれかの方法により製造される可溶性グルカン 13.任意に薬理学的に許容できる担体、若しくは賦形剤と結合して、請求項1 0記載の方法により製造されるグルカンゲル。 14.実質的に分岐β−(1,3)(1,6)−グルカンからなり、実質的に非 分岐β(1,3)グルカンがない、任意に一以上の薬理学的に許容できる担体、 若しくは賦形剤と結合する、組成物。 15.該グルカンが微粒子で、水溶液に可溶性で、若しくはゲル剤である請求項 1記載のグルカン組成物。 16.皮膚潰瘍、若しくは骨折の治療、又は移植用の整形具の固定の強化、又は 紫外光誘発の皮膚障害の予防/治療のための医薬品の製造のためのグルカンの利 用。 17.皮膚潰瘍、若しくは骨折の治療、又は移植用の整形具の固定の強化、又は 紫外光誘発の皮膚障害の予防/治療のためのグルカンの利用。 18.皮膚潰瘍、若しくは骨折の治療、又は移植用整形具の固定の強化、又は紫 外光誘発の皮膚障害の予防/治療のためにグルカンを、任意に一以上の薬理学的 に、獣医学的に、若しくは農業用に許容できる担体、若しくは賦形剤と結合して 、対象に投与することよりなる方法。 19.皮膚潰瘍、若しくは骨折の治療、又は移植用整形具の固定の強化、又は紫 外光誘発の皮膚障害の予防/治療のための、任意に一以上の薬理学的に許容でき る担体、若しくは賦形剤と結合して、グルカンを含有する薬剤。 20.該グルカンが請求項1から10までのいずれかにより製造される請求項1 6または17記載のグルカンの利用。 21.該グルカンが請求項1から10までのいずれかにより製造される請求項1 8記載の方法。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AUPN1661A AUPN166195A0 (en) | 1995-03-13 | 1995-03-13 | Process for glucan extraction |
AU1661 | 1995-03-13 | ||
PCT/AU1996/000138 WO1996028476A1 (en) | 1995-03-13 | 1996-03-13 | Process for glucan preparation and therapeutic uses of glucan |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2007309589A Division JP2008063349A (ja) | 1995-03-13 | 2007-11-30 | グルカンを含む薬剤、医薬組成物、及びグルカンを使用する薬剤の製造方法。 |
Publications (2)
Publication Number | Publication Date |
---|---|
JPH11501691A true JPH11501691A (ja) | 1999-02-09 |
JP4197736B2 JP4197736B2 (ja) | 2008-12-17 |
Family
ID=3786016
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP52711496A Expired - Fee Related JP4197736B2 (ja) | 1995-03-13 | 1996-03-13 | グルカンの製造方法、及びグルカンの治療用途 |
JP2007309589A Pending JP2008063349A (ja) | 1995-03-13 | 2007-11-30 | グルカンを含む薬剤、医薬組成物、及びグルカンを使用する薬剤の製造方法。 |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2007309589A Pending JP2008063349A (ja) | 1995-03-13 | 2007-11-30 | グルカンを含む薬剤、医薬組成物、及びグルカンを使用する薬剤の製造方法。 |
Country Status (9)
Country | Link |
---|---|
US (5) | US6242594B1 (ja) |
EP (1) | EP0815144B1 (ja) |
JP (2) | JP4197736B2 (ja) |
AT (1) | ATE254634T1 (ja) |
AU (1) | AUPN166195A0 (ja) |
DE (1) | DE69630779T2 (ja) |
ES (1) | ES2211943T3 (ja) |
GB (1) | GB2314850B (ja) |
WO (1) | WO1996028476A1 (ja) |
Cited By (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2001354570A (ja) * | 2000-06-15 | 2001-12-25 | Ichimaru Pharcos Co Ltd | 免疫賦活剤及びそれを利用した香粧品 |
JP2002539145A (ja) * | 1999-03-12 | 2002-11-19 | バイオテク エイエスエイ | 界面活性剤混合物の使用 |
JP2002539147A (ja) * | 1999-03-12 | 2002-11-19 | バイオテク エイエスエイ | ナノスカラー水溶性β−(1,3)グルカンの使用 |
JP2006502186A (ja) * | 2002-09-20 | 2006-01-19 | モーメンタム ファーマシューティカルズ | 骨粗鬆症および他の骨吸収疾患を処置するためのβ−グルカンの使用 |
JP2006507239A (ja) * | 2002-08-13 | 2006-03-02 | バイオポリマー エンジニアリング,インコーポレイテッド | 放射線防護剤としてのベータグルカンの使用方法 |
JP2007045714A (ja) * | 2005-08-05 | 2007-02-22 | Kirin Brewery Co Ltd | 皮膚状態改善組成物 |
JP2010090070A (ja) * | 2008-10-09 | 2010-04-22 | Daiso Co Ltd | β−1,3−1,6−D−グルカンを用いた消化管粘膜保護剤または下痢抑制剤 |
JP2010131017A (ja) * | 2002-05-15 | 2010-06-17 | Luciano Polonelli | グルカンベースのワクチン |
JP2010526810A (ja) * | 2007-05-08 | 2010-08-05 | バイオポリマー エンジニアリング インコーポレイテッド ディービーエイ バイオセラ インコーポレイテッド | 微粒子−可溶性グルカン調製物 |
JP2010529980A (ja) * | 2007-06-13 | 2010-09-02 | グリコス フィンランド オイ | 栄養組成物 |
JP2013155203A (ja) * | 2006-11-02 | 2013-08-15 | Aureo Co Ltd | 生体治癒促進剤 |
JP2013544817A (ja) * | 2010-11-29 | 2013-12-19 | ビオテック ファルマコン アルメン アクスイェ セルスカプ | グルカン組成物 |
JP2014025079A (ja) * | 2006-06-15 | 2014-02-06 | Biothera Inc | グルカンの調製 |
US8883760B2 (en) | 2002-09-04 | 2014-11-11 | University Of Louisville Research Foundation, Inc. | Cancer therapy using beta glucan and antibodies |
JPWO2019142921A1 (ja) * | 2018-01-19 | 2020-04-02 | 日本製紙株式会社 | 化粧用組成物 |
WO2022244580A1 (ja) * | 2021-05-21 | 2022-11-24 | アサヒグループホールディングス株式会社 | 免疫賦活剤及びグルカン組成物の製造方法 |
Families Citing this family (101)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK0656786T3 (da) * | 1992-05-19 | 2004-11-08 | Novogen Res Pty Ltd | Anvendelse af isoflavonphytoöstrogenekstrakter af soja eller klöver |
AUPN166195A0 (en) * | 1995-03-13 | 1995-04-06 | Norvet Research Pty Limited | Process for glucan extraction |
DE19710368A1 (de) * | 1997-03-13 | 1998-09-17 | Henkel Kgaa | Verwendung von wasserlöslichen beta-Glucanen als Wirkstoffe zur Herstellung von therapeutischen Mitteln zur Hautbehandlung |
JP4150501B2 (ja) * | 1997-12-24 | 2008-09-17 | シャクリー コーポレイション | 紫外光の傷害作用からの高効率皮膚保護を備える組成物 |
AUPP112497A0 (en) * | 1997-12-24 | 1998-01-22 | Novogen Research Pty Ltd | Compositions and method for protecting skin from UV induced immunosupression and skin damage |
WO2000054742A1 (de) * | 1999-03-12 | 2000-09-21 | Biotec Asa | VERWENDUNG VON WASSERLÖSLICHEN β-(1,3)-GLUCANEN ALS WIRKSTOFFE ZUR HERSTELLUNG VON THERAPEUTISCHEN MITTELN ZUR HAUTBEHANDLUNG |
US8912165B2 (en) | 1999-03-12 | 2014-12-16 | Biotec Pharmacon Asa | Methods of skin treatment and use of water-soluble β-(1,3) glucans as active agents for producing therapeutic skin treatment agents |
US8501710B2 (en) * | 1999-03-12 | 2013-08-06 | Biotec Pharmacon Asa | Methods of skin treatment and use of water-soluble β-(1,3) glucans as active agents for producing therapeutic skin treatment agents |
DE19917744A1 (de) * | 1999-04-20 | 2000-10-26 | Cognis Deutschland Gmbh | Dekorative kosmetische Zubereitungen |
KR100717742B1 (ko) | 1999-07-21 | 2007-05-11 | 가부시키가이샤 야쿠루트 혼샤 | 콜레스테롤 저하제,2차 담즙산 생산 억제제 및 음식품 |
US6541678B2 (en) * | 1999-09-27 | 2003-04-01 | Brennen Medical, Inc. | Immunostimulating coating for surgical devices |
US20020009463A1 (en) * | 2000-02-23 | 2002-01-24 | Jan Raa | Novel, non-antigenic, mucosal adjuvant formulation which enhances the effects of substances, including vaccine antigens, in contact with mucosal body surfaces |
US6713459B1 (en) * | 2000-04-28 | 2004-03-30 | East Tennessee State University | Methods for the prophylactic and therapeutic treatment of cardiac tissue damage |
US20040054166A1 (en) | 2000-08-03 | 2004-03-18 | Martin Sauter | Isolation of glucan particles and uses thereof |
US6531178B2 (en) | 2000-12-08 | 2003-03-11 | Quaker Oats/Rhone-Poulenc Partnership | β-glucan process, additive and food product |
US8222232B2 (en) * | 2001-02-16 | 2012-07-17 | Cargill, Incorporated | Glucosamine and N-acetylglucosamine compositions and methods of making the same fungal biomass |
US7923437B2 (en) * | 2001-02-16 | 2011-04-12 | Cargill, Incorporated | Water soluble β-glucan, glucosamine, and N-acetylglucosamine compositions and methods for making the same |
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GB2314850B (en) | 1999-07-14 |
EP0815144A4 (en) | 2001-01-10 |
DE69630779T2 (de) | 2004-09-23 |
US20070142320A1 (en) | 2007-06-21 |
US20040082539A1 (en) | 2004-04-29 |
GB9717617D0 (en) | 1997-10-22 |
DE69630779D1 (de) | 2003-12-24 |
US20060293278A1 (en) | 2006-12-28 |
JP4197736B2 (ja) | 2008-12-17 |
AUPN166195A0 (en) | 1995-04-06 |
EP0815144B1 (en) | 2003-11-19 |
US20060287277A1 (en) | 2006-12-21 |
US7776843B2 (en) | 2010-08-17 |
US7622575B2 (en) | 2009-11-24 |
US7648968B2 (en) | 2010-01-19 |
US6242594B1 (en) | 2001-06-05 |
WO1996028476A1 (en) | 1996-09-19 |
ES2211943T3 (es) | 2004-07-16 |
JP2008063349A (ja) | 2008-03-21 |
EP0815144A1 (en) | 1998-01-07 |
ATE254634T1 (de) | 2003-12-15 |
GB2314850A (en) | 1998-01-14 |
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