JP7217700B2 - 安定化非タンパク質クロストリジウム毒素組成物 - Google Patents

安定化非タンパク質クロストリジウム毒素組成物 Download PDF

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Publication number
JP7217700B2
JP7217700B2 JP2019513907A JP2019513907A JP7217700B2 JP 7217700 B2 JP7217700 B2 JP 7217700B2 JP 2019513907 A JP2019513907 A JP 2019513907A JP 2019513907 A JP2019513907 A JP 2019513907A JP 7217700 B2 JP7217700 B2 JP 7217700B2
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Prior art keywords
pharmaceutical composition
clostridial toxin
sites
weight
toxin
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JP2019513907A
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Japanese (ja)
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JP2019526609A (ja
Inventor
モーリス アビアド
バス ダニ
エヴゲニー シャラエフ
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Allergan Inc
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Allergan Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/4886—Metalloendopeptidases (3.4.24), e.g. collagenase
    • A61K38/4893—Botulinum neurotoxin (3.4.24.69)
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    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/164—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
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    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
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    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
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    • A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
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    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
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    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
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    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
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    • A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
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    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
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    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
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    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
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    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/24—Metalloendopeptidases (3.4.24)
    • C12Y304/24069—Bontoxilysin (3.4.24.69), i.e. botulinum neurotoxin
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    • A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
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    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Dermatology (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Inorganic Chemistry (AREA)
  • Birds (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Cardiology (AREA)
  • Neurosurgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • General Engineering & Computer Science (AREA)
  • Toxicology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
JP2019513907A 2016-09-13 2017-09-13 安定化非タンパク質クロストリジウム毒素組成物 Active JP7217700B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662394009P 2016-09-13 2016-09-13
US62/394,009 2016-09-13
PCT/US2017/051394 WO2018053021A1 (en) 2016-09-13 2017-09-13 Stabilized non-protein clostridial toxin compositions

Publications (2)

Publication Number Publication Date
JP2019526609A JP2019526609A (ja) 2019-09-19
JP7217700B2 true JP7217700B2 (ja) 2023-02-03

Family

ID=59974865

Family Applications (4)

Application Number Title Priority Date Filing Date
JP2019513907A Active JP7217700B2 (ja) 2016-09-13 2017-09-13 安定化非タンパク質クロストリジウム毒素組成物
JP2019513915A Abandoned JP2019526611A (ja) 2016-09-13 2017-09-13 非タンパク質クロストリジウム毒素組成物
JP2022143910A Active JP7675053B2 (ja) 2016-09-13 2022-09-09 非タンパク質クロストリジウム毒素組成物
JP2025072942A Pending JP2025121944A (ja) 2016-09-13 2025-04-25 非タンパク質クロストリジウム毒素組成物

Family Applications After (3)

Application Number Title Priority Date Filing Date
JP2019513915A Abandoned JP2019526611A (ja) 2016-09-13 2017-09-13 非タンパク質クロストリジウム毒素組成物
JP2022143910A Active JP7675053B2 (ja) 2016-09-13 2022-09-09 非タンパク質クロストリジウム毒素組成物
JP2025072942A Pending JP2025121944A (ja) 2016-09-13 2025-04-25 非タンパク質クロストリジウム毒素組成物

Country Status (28)

Country Link
US (10) US10369190B2 (enExample)
EP (4) EP3432916B1 (enExample)
JP (4) JP7217700B2 (enExample)
KR (6) KR102480965B1 (enExample)
CN (3) CN109803673A (enExample)
AU (4) AU2017327369A1 (enExample)
BR (2) BR112019004929A2 (enExample)
CA (2) CA3035473A1 (enExample)
CL (1) CL2019000586A1 (enExample)
CO (1) CO2019003630A2 (enExample)
CY (2) CY1122263T1 (enExample)
DK (2) DK3432916T3 (enExample)
ES (2) ES2755815T3 (enExample)
HR (1) HRP20191966T4 (enExample)
HU (2) HUE046449T2 (enExample)
IL (2) IL265109B2 (enExample)
LT (1) LT3436054T (enExample)
MX (2) MX2019002835A (enExample)
PH (1) PH12019500501A1 (enExample)
PL (2) PL3432916T3 (enExample)
PT (2) PT3436054T (enExample)
RS (1) RS59600B2 (enExample)
RU (2) RU2762607C2 (enExample)
SA (1) SA519401298B1 (enExample)
SI (2) SI3436054T2 (enExample)
SM (1) SMT201900625T1 (enExample)
TW (2) TWI773686B (enExample)
WO (2) WO2018053021A1 (enExample)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8168206B1 (en) 2005-10-06 2012-05-01 Allergan, Inc. Animal protein-free pharmaceutical compositions
HUE046449T2 (hu) * 2016-09-13 2020-03-30 Allergan Inc Stabilizált, nem fehérje eredetû, clostridiális toxin készítmények
KR102646145B1 (ko) 2018-05-31 2024-03-11 주식회사 엑소코바이오 줄기세포 유래의 엑소좀을 유효성분으로 포함하는 모공 축소용 조성물
KR102058961B1 (ko) 2018-07-28 2019-12-24 주식회사 엑소코바이오 엑소좀의 동결건조 방법
KR102163806B1 (ko) 2018-07-30 2020-10-07 주식회사 엑소코바이오 줄기세포 유래의 엑소좀을 유효성분으로 포함하는 피지분비 감소용 조성물
US20200108129A1 (en) * 2018-09-13 2020-04-09 Allergan, Inc. Clostridial toxin - hyaluronic acid compositions
KR102259423B1 (ko) * 2018-11-30 2021-06-02 주식회사 휴온스바이오파마 보툴리눔 독소의 안정화 액상 조성물
WO2020231700A1 (en) * 2019-05-11 2020-11-19 Youngsuk Yi Neurotoxin compositions and methods
UY38744A (es) * 2019-06-07 2020-12-31 Nestle Skin Health S A Tratamiento de líneas glabelares y líneas cantales laterales de moderadas a muy graves
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