ATE533853T1 - Botulinumtoxin-screening-assays - Google Patents
Botulinumtoxin-screening-assaysInfo
- Publication number
- ATE533853T1 ATE533853T1 AT05724048T AT05724048T ATE533853T1 AT E533853 T1 ATE533853 T1 AT E533853T1 AT 05724048 T AT05724048 T AT 05724048T AT 05724048 T AT05724048 T AT 05724048T AT E533853 T1 ATE533853 T1 AT E533853T1
- Authority
- AT
- Austria
- Prior art keywords
- methods
- botulinum toxin
- screening assays
- bont
- toxin screening
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56911—Bacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/475—Assays involving growth factors
- G01N2333/50—Fibroblast growth factors [FGF]
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Chemical & Material Sciences (AREA)
- Urology & Nephrology (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Biochemistry (AREA)
- Analytical Chemistry (AREA)
- Food Science & Technology (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- External Artificial Organs (AREA)
- Measuring And Recording Apparatus For Diagnosis (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US54759104P | 2004-02-24 | 2004-02-24 | |
PCT/US2005/006421 WO2005082096A2 (en) | 2004-02-24 | 2005-02-23 | Botulinum toxin screening assays |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE533853T1 true ATE533853T1 (de) | 2011-12-15 |
Family
ID=34910920
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT05724048T ATE533853T1 (de) | 2004-02-24 | 2005-02-23 | Botulinumtoxin-screening-assays |
Country Status (9)
Country | Link |
---|---|
US (3) | US7598027B2 (de) |
EP (1) | EP1718756B1 (de) |
JP (1) | JP4970057B2 (de) |
AT (1) | ATE533853T1 (de) |
AU (2) | AU2005216547B2 (de) |
CA (1) | CA2558758C (de) |
DK (1) | DK1718756T3 (de) |
ES (1) | ES2374822T3 (de) |
WO (1) | WO2005082096A2 (de) |
Families Citing this family (40)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20080064054A1 (en) * | 2001-08-28 | 2008-03-13 | Ester Fernandez-Salas | Fluorescence resonance energy transfer (fret) assays for clostridial toxin activity |
US8022172B2 (en) * | 2001-08-28 | 2011-09-20 | Allergan, Inc. | Luminescence resonance energy transfer (LRET) assays for clostridial toxin activity |
US7208285B2 (en) | 2001-08-28 | 2007-04-24 | Allergan, Inc. | Fret protease assays for botulinum serotype A/E toxins |
US7374896B2 (en) * | 2001-08-28 | 2008-05-20 | Allergan, Inc. | GFP-SNAP25 fluorescence release assay for botulinum neurotoxin protease activity |
US7332567B2 (en) * | 2001-08-28 | 2008-02-19 | Allergan, Inc. | Fret protease assays for clostridial toxins |
US7183066B2 (en) * | 2002-09-27 | 2007-02-27 | Allergan, Inc. | Cell-based fluorescence resonance energy transfer (FRET) assays for clostridial toxins |
US7598027B2 (en) * | 2004-02-24 | 2009-10-06 | Allergan, Inc. | Botulinum toxin screening assays |
US8497081B2 (en) * | 2004-02-24 | 2013-07-30 | Allergan, Inc. | Botulinum toxin screening assays |
US7514088B2 (en) * | 2005-03-15 | 2009-04-07 | Allergan, Inc. | Multivalent Clostridial toxin derivatives and methods of their use |
US20080274480A1 (en) * | 2004-08-04 | 2008-11-06 | Allergan, Inc. | Botulinum Toxin Type a Immunoresistant Assay |
CA2601577A1 (en) * | 2005-03-15 | 2006-09-21 | Allergan, Inc. | Modified clostridial toxins with altered targeting capabilities for clostridial toxin target cells |
DE602006012072D1 (de) * | 2005-10-12 | 2010-03-18 | Allergan Inc | Tests der molekularen oder subzellulären interaktivität unter verwendung von depolarisierung nach resonanzenergietransfer (daret) |
JP2009543556A (ja) * | 2006-07-11 | 2009-12-10 | アラーガン、インコーポレイテッド | 増強した転位置能力および増強したターゲティング活性を有する改変クロストリジウム毒素 |
WO2009042165A2 (en) * | 2007-09-25 | 2009-04-02 | Thomas Jefferson University | Mutant botulinum neurotoxin serotype a polypeptide and uses thereof |
PL2271670T3 (pl) | 2008-03-14 | 2015-05-29 | Allergan Inc | Testy aktywności serotypu A toksyny botulinowej oparte na immunologii |
KR101604515B1 (ko) * | 2008-03-14 | 2016-03-17 | 알러간, 인코포레이티드 | 면역-기반 보툴리눔 독소 세로타입 a 활성 검정 |
EP2313435A4 (de) * | 2008-07-01 | 2012-08-08 | Aveo Pharmaceuticals Inc | An den fibroblastenwachstumsfaktorrezeptor 3 (fgfr3) bindende proteine |
WO2010090677A1 (en) | 2008-12-10 | 2010-08-12 | Allergan, Inc. | Clostridial toxin pharmaceutical compositions |
US8492109B2 (en) | 2009-01-20 | 2013-07-23 | Trustees Of Tufts College | Methods for the delivery of toxins or enzymatically active portions thereof |
PT3281953T (pt) * | 2009-03-13 | 2020-01-15 | Allergan Inc | Ensaios de base imunológica da actividade de endopeptidase redireccionada |
EP2406371B1 (de) | 2009-03-13 | 2018-05-09 | Allergan, Inc. | Für botulinumtoxin-serotyp-a-aktivitätstests auf immunbasis geeignete zellen |
US8129139B2 (en) | 2009-07-13 | 2012-03-06 | Allergan, Inc. | Process for obtaining botulinum neurotoxin |
MX348188B (es) * | 2011-09-29 | 2017-06-01 | Cellsnap Llc | Composiciones y metodos para pruebas de toxigenicidad. |
EP2798077A2 (de) | 2011-12-31 | 2014-11-05 | Allergan, Inc. | Hochempfindlicher zellbasierter test für den nachweis der anwesenheit von aktivem botulinum-neurotoxin-serotyp-a |
US20150153325A1 (en) * | 2012-05-11 | 2015-06-04 | Patrick McNutt | Toxin detection using stem cell derived neurons |
BR112014029585A2 (pt) | 2012-05-30 | 2017-07-25 | Harvard College | neurotoxina botulínica engendrada |
US8962340B2 (en) | 2012-12-03 | 2015-02-24 | Src, Inc. | Real-time assay for the detection of botulinum toxin |
AU2013373679A1 (en) | 2013-01-16 | 2015-08-13 | Inserm (Institut National De La Sante Et De La Recherche Medicale) | A soluble fibroblast growth factor receptor 3 (FGR3) polypeptide for use in the prevention or treatment of skeletal growth retardation disorders |
ES2818986T5 (es) * | 2013-08-09 | 2024-01-25 | Biomadison Inc | Ensayo de toxina botulínica con sensibilidad mejorada |
JP6630717B2 (ja) | 2014-07-07 | 2020-01-15 | アラーガン、インコーポレイテッドAllergan,Incorporated | 組織試料における切断snap25の検出方法 |
CN107548402B (zh) | 2015-03-26 | 2022-08-19 | 哈佛大学校长及研究员协会 | 工程改造的肉毒杆菌神经毒素 |
KR102432192B1 (ko) | 2016-07-07 | 2022-08-12 | 화이자 인코포레이티드 | 가용성 섬유아세포 성장 인자 수용체 3(sfgfr3) 폴리펩티드 및 이의 용도 |
EP3504226A1 (de) | 2016-08-24 | 2019-07-03 | President and Fellows of Harvard College | Manipuliertes botulinumneurotoxin |
JP7217700B2 (ja) | 2016-09-13 | 2023-02-03 | アラーガン、インコーポレイテッド | 安定化非タンパク質クロストリジウム毒素組成物 |
US11129906B1 (en) | 2016-12-07 | 2021-09-28 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
CN112351992A (zh) | 2017-12-20 | 2021-02-09 | 阿勒根公司 | 肉毒杆菌毒素细胞结合结构域多肽及其用于皮肤再生的方法 |
LT3660509T (lt) * | 2018-11-29 | 2022-05-10 | Hugel Inc. | Ląstelių panaudojimu paremtas būdas botulino toksino aktyvumui nustatyti |
KR101940500B1 (ko) * | 2018-11-29 | 2019-01-21 | 주식회사 에이비바이오 | 보툴리눔 독소 활성을 결정하기 위한 세포주 및 이를 이용한 활성 결정 방법 |
JP2020015733A (ja) * | 2019-08-19 | 2020-01-30 | アンセルムInserm | 骨格成長遅延障害の予防または処置における使用のための、可溶性線維芽細胞増殖因子受容体3(fgr3)ポリペプチド |
JP2023538098A (ja) | 2020-08-21 | 2023-09-06 | ジェンザイム・コーポレーション | Fgfr3抗体および使用の方法 |
Family Cites Families (33)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5750365A (en) | 1993-05-28 | 1998-05-12 | The Ohio State University Research Foundation | Isolated nucleic acid encoding a newt acidic fibroblast growth factor (AFGF) |
US5962637A (en) * | 1994-06-03 | 1999-10-05 | Microbiological Research Authority | Toxin assay |
US5731161A (en) * | 1995-04-24 | 1998-03-24 | Allergan, Inc. | Botulinum toxin antibody detection assay |
US5965699A (en) * | 1996-11-06 | 1999-10-12 | The United States Of America As Represented By The Secretary Of The Army | Assay for the proteolytic activity of serotype a from clostridium botulinum |
US7923216B2 (en) * | 1997-08-14 | 2011-04-12 | Institut Pasteur | In vivo modulation of neuronal transport |
US7923015B2 (en) * | 1997-08-14 | 2011-04-12 | Institut Pasteur | Methods for direct visualization of active synapses |
US6794128B2 (en) * | 1998-04-24 | 2004-09-21 | The Regents Of The University Of California | Methods of selecting internalizing antibodies |
IL128380A0 (en) | 1999-02-04 | 2000-01-31 | Yeda Res & Dev | A method of screening for agonists and antagonists of FGFR |
JP2003509045A (ja) * | 1999-09-15 | 2003-03-11 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | ニコチン性アセチルコリン受容体:アルファ10サブユニット |
US20030219462A1 (en) * | 2000-07-21 | 2003-11-27 | Allergan Sales, Inc | Clostridial neurotoxin compositions and modified clostridial neurotoxins |
US6913877B1 (en) * | 2000-09-11 | 2005-07-05 | State Of Oregon Acting By And Through The State Board Of Higher Education On Behalf Of Oregon State University | Methods for detecting bioactive compounds |
IL138529A0 (en) * | 2000-09-18 | 2003-09-17 | Yeda Res & Dev | High level expression of heterologous proteins |
US7415358B2 (en) * | 2001-05-22 | 2008-08-19 | Ocimum Biosolutions, Inc. | Molecular toxicology modeling |
AU2002314495A1 (en) | 2001-06-20 | 2003-01-02 | Prochon Biotech Ltd. | Antibodies that block receptor protein tyrosine kinase activation, methods of screening for and uses thereof |
US20080064054A1 (en) * | 2001-08-28 | 2008-03-13 | Ester Fernandez-Salas | Fluorescence resonance energy transfer (fret) assays for clostridial toxin activity |
US7208285B2 (en) * | 2001-08-28 | 2007-04-24 | Allergan, Inc. | Fret protease assays for botulinum serotype A/E toxins |
US20070118934A1 (en) * | 2001-10-26 | 2007-05-24 | Planet Biotechnology, Inc. | Chimeric toxin receptor proteins and chimeric toxin receptor proteins for treatment and prevention of anthrax |
WO2003083046A2 (en) * | 2002-03-08 | 2003-10-09 | Curagen Corporation | Novel proteins and nucleic acids encoding same |
IL149562A0 (en) * | 2002-05-09 | 2002-11-10 | Prochon Ltd | Fgf variants and methods for use thereof |
JP2005538954A (ja) * | 2002-05-31 | 2005-12-22 | トーマス・ジェファーソン・ユニバーシティ | 分子の経上皮輸送用組成物及び方法 |
US7183066B2 (en) | 2002-09-27 | 2007-02-27 | Allergan, Inc. | Cell-based fluorescence resonance energy transfer (FRET) assays for clostridial toxins |
EP1625378A4 (de) * | 2002-12-03 | 2007-05-16 | Ucb Sa | VERFAHREN ZUR IDENTIFIZIERUNG VONAGENTIEN ZUR BEHANDLUNG VON ANFûLLEN, NEUROLOGISCHEN ERKRANKUNGEN,ENDOKRINOPATHIEN UND HORMONKRANKHEITEN |
US7090985B2 (en) * | 2002-12-03 | 2006-08-15 | Ucb, S.A. | Methods for the identification of agents for the treatment of seizures, neurological diseases, endocrinopathies and hormonal diseases |
WO2004076634A2 (en) * | 2003-02-24 | 2004-09-10 | Ira Sanders | Cell membrane translocation of regulated snare inhibitors , compositions therefor, and methods for treatment of disease |
IL156495A0 (en) | 2003-06-17 | 2004-01-04 | Prochon Biotech Ltd | Use of fgfr3 antagonists for treating t cell mediated diseases |
BRPI0417157A (pt) * | 2003-12-02 | 2007-03-06 | Ucb Sa | composto, composição farmacêutica, e, uso de um composto ou de uma composição farmacêutica |
US8048423B2 (en) * | 2003-12-09 | 2011-11-01 | Allergan, Inc. | Botulinum toxin therapy for skin disorders |
US20050129677A1 (en) * | 2003-12-10 | 2005-06-16 | Shengwen Li | Lipid rafts and clostridial toxins |
JP4656836B2 (ja) * | 2003-12-19 | 2011-03-23 | パナソニック株式会社 | 同期クロック生成装置及び同期クロック生成方法 |
US7598027B2 (en) * | 2004-02-24 | 2009-10-06 | Allergan, Inc. | Botulinum toxin screening assays |
US20050288247A1 (en) * | 2004-06-25 | 2005-12-29 | Cold Spring Harbor Laboratory | Inducible inactivation of synaptic transmission |
EP2293064B1 (de) * | 2005-04-05 | 2012-04-04 | Allergan, Inc. | Lipophile, farbstoffbasierte FRET-Assays für die Clostridientoxinaktivität |
EP1985276A1 (de) * | 2007-04-26 | 2008-10-29 | Merz Pharma GmbH & Co. KGaA | Behandlung von Bewegungsstörungen durch die Verwendung einer Kombination aus einem Muskel entspannenden Wirkstoff und einer Bewegungstherapie |
-
2005
- 2005-02-23 US US10/598,073 patent/US7598027B2/en not_active Expired - Fee Related
- 2005-02-23 ES ES05724048T patent/ES2374822T3/es active Active
- 2005-02-23 WO PCT/US2005/006421 patent/WO2005082096A2/en active Application Filing
- 2005-02-23 JP JP2006554350A patent/JP4970057B2/ja not_active Expired - Fee Related
- 2005-02-23 AT AT05724048T patent/ATE533853T1/de active
- 2005-02-23 CA CA2558758A patent/CA2558758C/en not_active Expired - Fee Related
- 2005-02-23 AU AU2005216547A patent/AU2005216547B2/en not_active Ceased
- 2005-02-23 EP EP05724048A patent/EP1718756B1/de not_active Not-in-force
- 2005-02-23 DK DK05724048.3T patent/DK1718756T3/da active
-
2008
- 2008-03-13 US US12/047,441 patent/US7645570B2/en not_active Expired - Fee Related
-
2009
- 2009-05-28 AU AU2009202136A patent/AU2009202136B2/en not_active Ceased
- 2009-08-21 US US12/545,647 patent/US8257914B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
EP1718756A4 (de) | 2008-06-04 |
CA2558758C (en) | 2015-06-23 |
US8257914B2 (en) | 2012-09-04 |
EP1718756A2 (de) | 2006-11-08 |
AU2009202136B2 (en) | 2011-12-22 |
US7598027B2 (en) | 2009-10-06 |
JP2007526770A (ja) | 2007-09-20 |
US20080182799A1 (en) | 2008-07-31 |
US20090317839A1 (en) | 2009-12-24 |
WO2005082096A2 (en) | 2005-09-09 |
US7645570B2 (en) | 2010-01-12 |
EP1718756B1 (de) | 2011-11-16 |
JP4970057B2 (ja) | 2012-07-04 |
ES2374822T3 (es) | 2012-02-22 |
US20080003240A1 (en) | 2008-01-03 |
WO2005082096A3 (en) | 2006-06-22 |
AU2005216547A1 (en) | 2005-09-09 |
CA2558758A1 (en) | 2005-09-09 |
AU2009202136A1 (en) | 2009-06-18 |
DK1718756T3 (da) | 2012-02-27 |
AU2005216547B2 (en) | 2009-03-12 |
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