ATE456798T1 - Tests der molekularen oder subzellulären interaktivität unter verwendung von depolarisierung nach resonanzenergietransfer (daret) - Google Patents
Tests der molekularen oder subzellulären interaktivität unter verwendung von depolarisierung nach resonanzenergietransfer (daret)Info
- Publication number
- ATE456798T1 ATE456798T1 AT06816778T AT06816778T ATE456798T1 AT E456798 T1 ATE456798 T1 AT E456798T1 AT 06816778 T AT06816778 T AT 06816778T AT 06816778 T AT06816778 T AT 06816778T AT E456798 T1 ATE456798 T1 AT E456798T1
- Authority
- AT
- Austria
- Prior art keywords
- daret
- molecular
- interactivity
- depolarization
- cellular
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/536—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
- G01N33/542—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with steric inhibition or signal modification, e.g. fluorescent quenching
Landscapes
- Health & Medical Sciences (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Food Science & Technology (AREA)
- General Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Pathology (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
- Measurement Of Resistance Or Impedance (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US72651505P | 2005-10-12 | 2005-10-12 | |
PCT/US2006/039846 WO2007047342A1 (en) | 2005-10-12 | 2006-10-11 | Assays of molecular or subcellular interactivity using depolarization after resonance energy transfer (daret) |
US11/548,411 US7998749B2 (en) | 2005-10-12 | 2006-10-11 | Assays of molecular or subcellular interactivity using depolarization after resonance transfer energy (DARET) |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE456798T1 true ATE456798T1 (de) | 2010-02-15 |
Family
ID=37806796
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT06816778T ATE456798T1 (de) | 2005-10-12 | 2006-10-11 | Tests der molekularen oder subzellulären interaktivität unter verwendung von depolarisierung nach resonanzenergietransfer (daret) |
AT09010300T ATE555387T1 (de) | 2005-10-12 | 2006-10-11 | Tests der molekularen oder subzellulären nähe unter verwendung von depolarisierung nach resonanzenergietransfer (daret) |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT09010300T ATE555387T1 (de) | 2005-10-12 | 2006-10-11 | Tests der molekularen oder subzellulären nähe unter verwendung von depolarisierung nach resonanzenergietransfer (daret) |
Country Status (9)
Country | Link |
---|---|
US (1) | US7998749B2 (de) |
EP (2) | EP2131195B1 (de) |
JP (2) | JP2009521666A (de) |
AT (2) | ATE456798T1 (de) |
AU (1) | AU2006304151B2 (de) |
CA (1) | CA2602972C (de) |
DE (1) | DE602006012072D1 (de) |
ES (1) | ES2338368T3 (de) |
WO (1) | WO2007047342A1 (de) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9617671D0 (en) * | 1996-08-23 | 1996-10-02 | Microbiological Res Authority | Recombinant toxin fragments |
US20080064054A1 (en) * | 2001-08-28 | 2008-03-13 | Ester Fernandez-Salas | Fluorescence resonance energy transfer (fret) assays for clostridial toxin activity |
US7374896B2 (en) * | 2001-08-28 | 2008-05-20 | Allergan, Inc. | GFP-SNAP25 fluorescence release assay for botulinum neurotoxin protease activity |
US7332567B2 (en) * | 2001-08-28 | 2008-02-19 | Allergan, Inc. | Fret protease assays for clostridial toxins |
US7208285B2 (en) * | 2001-08-28 | 2007-04-24 | Allergan, Inc. | Fret protease assays for botulinum serotype A/E toxins |
US7183066B2 (en) * | 2002-09-27 | 2007-02-27 | Allergan, Inc. | Cell-based fluorescence resonance energy transfer (FRET) assays for clostridial toxins |
US7399607B2 (en) * | 2004-09-22 | 2008-07-15 | Allergan, Inc. | Fluorescence polarization assays for determining clostridial toxin activity |
US8999666B2 (en) * | 2006-08-09 | 2015-04-07 | Intrexon Corporation | PKC ligands and polynucleotides encoding PKC ligands |
CA2699612C (en) | 2007-09-14 | 2013-01-08 | Biosentinel, Llc | Resonance energy transfer assay with cleavage sequence and spacer |
ES2524312T3 (es) | 2008-03-14 | 2014-12-05 | Allergan, Inc. | Ensayos de actividad de serotipo A de toxina botulínica de base inmunológica |
KR101604515B1 (ko) * | 2008-03-14 | 2016-03-17 | 알러간, 인코포레이티드 | 면역-기반 보툴리눔 독소 세로타입 a 활성 검정 |
US8993715B2 (en) * | 2009-07-06 | 2015-03-31 | Canon Kabushiki Kaisha | Labeled protein and method for obtaining the same |
US20110312732A1 (en) * | 2010-06-17 | 2011-12-22 | Geneasys Pty Ltd | Test module using lanthanide metal-ligand complex, electrochemiluminescent luminophores |
WO2013102088A2 (en) | 2011-12-31 | 2013-07-04 | Allergan, Inc. | Highly Sensitive Cell-Based Assay to Detect the Presence of Active Botulinum Neurotoxin Serotype-A |
CN105996968A (zh) * | 2016-05-09 | 2016-10-12 | 南京琦光光电科技有限公司 | 医疗内窥镜用led光源及光谱设计方法 |
Family Cites Families (44)
Publication number | Priority date | Publication date | Assignee | Title |
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US4211762A (en) | 1978-01-26 | 1980-07-08 | Huggins Keith G | Specific binding assay techniques |
EP0051985B2 (de) | 1980-11-07 | 1989-12-27 | International Institute Of Cellular And Molecular Pathology (Icp) | Immunologischer Test von Proteinen |
US4680258A (en) | 1981-03-24 | 1987-07-14 | Sloan-Kettering Institute For Cancer Research | Process for sex determination in man by use of monoclonal antibodies to the H-Y antigen |
US4427783A (en) | 1981-12-14 | 1984-01-24 | Hoffmann-La Roche Inc. | Immunoassay of thymosin α1 |
US4628027A (en) | 1982-05-19 | 1986-12-09 | Molecular Engineering Associates, Ltd. | Vitro diagnostic methods using monoclonal antibodies against connective tissue proteins |
US4659678A (en) | 1982-09-29 | 1987-04-21 | Serono Diagnostics Limited | Immunoassay of antigens |
CA2001774C (en) | 1988-10-28 | 2001-10-16 | James A. Wells | Method for identifying active domains and amino acid residues in polypeptides and hormone variants |
GB9310978D0 (en) | 1993-05-27 | 1993-07-14 | Zeneca Ltd | Compounds |
US5962637A (en) | 1994-06-03 | 1999-10-05 | Microbiological Research Authority | Toxin assay |
US6596522B2 (en) | 1997-05-08 | 2003-07-22 | The Regents Of The University Of California | Detection of transmembrane potentials by optical methods |
US5661035A (en) | 1995-06-07 | 1997-08-26 | The Regents Of The University Of California | Voltage sensing by fluorescence resonance energy transfer |
US6342379B1 (en) | 1995-06-07 | 2002-01-29 | The Regents Of The University Of California | Detection of transmembrane potentials by optical methods |
US6358709B1 (en) * | 1995-12-07 | 2002-03-19 | Diversa Corporation | End selection in directed evolution |
US6803188B1 (en) * | 1996-01-31 | 2004-10-12 | The Regents Of The University Of California | Tandem fluorescent protein constructs |
WO1999013332A1 (fr) | 1997-09-05 | 1999-03-18 | Matsushita Electric Industrial Co., Ltd. | Procede de polarisation de fluorescence |
WO2000042209A1 (en) * | 1999-01-15 | 2000-07-20 | Ljl Biosystems, Inc. | Methods and apparatus for detecting polynucleotide hybridization |
US6444421B1 (en) * | 1997-11-19 | 2002-09-03 | The United States Of America As Represented By The Department Of Health And Human Services | Methods for detecting intermolecular interactions in vivo and in vitro |
US7101681B1 (en) | 1997-11-21 | 2006-09-05 | Amgen, Inc. | Nuclear hormone receptor drug screens |
US6207392B1 (en) | 1997-11-25 | 2001-03-27 | The Regents Of The University Of California | Semiconductor nanocrystal probes for biological applications and process for making and using such probes |
EP1098658B1 (de) | 1998-07-17 | 2009-07-08 | University of Maryland, Baltimore | Manipulierte proteine zum analyten nachweis |
DE19860833C1 (de) | 1998-12-30 | 2000-09-07 | Albrecht E Sippel | Methode zur zellulären High-Throughput(Hochdurchsatz)-Detektion von Rezeptor-Liganden-Interaktionen |
US6972198B2 (en) | 1999-02-26 | 2005-12-06 | Cyclacel, Ltd. | Methods and compositions using protein binding partners |
JP2000333681A (ja) * | 1999-05-27 | 2000-12-05 | Nec Corp | タンパク質分解酵素切断配列を含有するタンパク質分解酵素用基質及びその発現用ベクター |
WO2001004300A1 (fr) | 1999-07-08 | 2001-01-18 | Helix Research Institute | Facteur associe a l'apoptose |
US6325899B1 (en) | 2000-03-10 | 2001-12-04 | Action Caps, Llc | Disposable and recyclable intermediates for use in electrostatic coating processes |
EP1195604A1 (de) | 2000-09-29 | 2002-04-10 | Warner-Lambert Company | Verfahren und Zusammensetzungen zum Screenen von Modulatoren von Lipidkinasen |
US20080064054A1 (en) | 2001-08-28 | 2008-03-13 | Ester Fernandez-Salas | Fluorescence resonance energy transfer (fret) assays for clostridial toxin activity |
US7374896B2 (en) | 2001-08-28 | 2008-05-20 | Allergan, Inc. | GFP-SNAP25 fluorescence release assay for botulinum neurotoxin protease activity |
US8022172B2 (en) | 2001-08-28 | 2011-09-20 | Allergan, Inc. | Luminescence resonance energy transfer (LRET) assays for clostridial toxin activity |
US7332567B2 (en) | 2001-08-28 | 2008-02-19 | Allergan, Inc. | Fret protease assays for clostridial toxins |
US7208285B2 (en) | 2001-08-28 | 2007-04-24 | Allergan, Inc. | Fret protease assays for botulinum serotype A/E toxins |
US20030087311A1 (en) * | 2001-11-07 | 2003-05-08 | Wolf David E. | Method of identifying energy transfer sensors for analytes |
CA2470820A1 (en) * | 2001-12-17 | 2003-06-26 | Powderject Research Limited | Diagnostic sensing apparatus |
US6942987B2 (en) * | 2002-05-15 | 2005-09-13 | Pharmacopeia Drug Discovery, Inc. | Methods for measuring kinase activity |
US6713262B2 (en) | 2002-06-25 | 2004-03-30 | Agilent Technologies, Inc. | Methods and compositions for high throughput identification of protein/nucleic acid binding pairs |
US7183066B2 (en) | 2002-09-27 | 2007-02-27 | Allergan, Inc. | Cell-based fluorescence resonance energy transfer (FRET) assays for clostridial toxins |
JP4214206B2 (ja) * | 2002-12-10 | 2009-01-28 | 独立行政法人理化学研究所 | Fretを利用した蛍光指示薬 |
US6969196B2 (en) * | 2003-03-07 | 2005-11-29 | Exopack-Technology, Llc | Bag having reclosable seal and associated methods |
JP2005017282A (ja) * | 2003-05-30 | 2005-01-20 | Olympus Corp | 受光ユニットおよびそれを含む測定装置 |
US7408640B2 (en) | 2003-11-05 | 2008-08-05 | The United States Of America As Represented By The Secretary Of The Navy | Fluorescence polarization instruments and methods for detection of exposure to biological materials by fluorescence polarization immunoassay of saliva, oral or bodily fluids |
US8137924B2 (en) * | 2003-12-19 | 2012-03-20 | Wisconsin Alumni Research Foundation | Method and compositions for detecting botulinum neurotoxin |
WO2005082096A2 (en) | 2004-02-24 | 2005-09-09 | Allergan, Inc. | Botulinum toxin screening assays |
US7399607B2 (en) | 2004-09-22 | 2008-07-15 | Allergan, Inc. | Fluorescence polarization assays for determining clostridial toxin activity |
ES2345506T3 (es) | 2005-04-05 | 2010-09-24 | Allergan, Inc. | Ensayos de fret a base de colorantes lipofilos para determinar la actividad de la toxina clostridial. |
-
2006
- 2006-10-11 AT AT06816778T patent/ATE456798T1/de not_active IP Right Cessation
- 2006-10-11 US US11/548,411 patent/US7998749B2/en active Active
- 2006-10-11 AT AT09010300T patent/ATE555387T1/de active
- 2006-10-11 AU AU2006304151A patent/AU2006304151B2/en not_active Ceased
- 2006-10-11 WO PCT/US2006/039846 patent/WO2007047342A1/en active Application Filing
- 2006-10-11 ES ES06816778T patent/ES2338368T3/es active Active
- 2006-10-11 DE DE602006012072T patent/DE602006012072D1/de active Active
- 2006-10-11 EP EP09010300A patent/EP2131195B1/de not_active Revoked
- 2006-10-11 CA CA2602972A patent/CA2602972C/en not_active Expired - Fee Related
- 2006-10-11 EP EP06816778A patent/EP1934610B1/de not_active Not-in-force
- 2006-10-11 JP JP2008535663A patent/JP2009521666A/ja active Pending
-
2013
- 2013-03-13 JP JP2013050465A patent/JP2013174595A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
AU2006304151A1 (en) | 2007-04-26 |
CA2602972C (en) | 2013-09-24 |
ES2338368T3 (es) | 2010-05-06 |
AU2006304151B2 (en) | 2012-01-19 |
EP2131195B1 (de) | 2012-04-25 |
WO2007047342A1 (en) | 2007-04-26 |
DE602006012072D1 (de) | 2010-03-18 |
JP2009521666A (ja) | 2009-06-04 |
EP1934610A1 (de) | 2008-06-25 |
CA2602972A1 (en) | 2007-04-26 |
EP2131195A1 (de) | 2009-12-09 |
EP1934610B1 (de) | 2010-01-27 |
US20070275477A1 (en) | 2007-11-29 |
ATE555387T1 (de) | 2012-05-15 |
JP2013174595A (ja) | 2013-09-05 |
US7998749B2 (en) | 2011-08-16 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |