DE60009661D1 - Methode zum nachweis von veränderungen zellulärer komponenten - Google Patents

Methode zum nachweis von veränderungen zellulärer komponenten

Info

Publication number
DE60009661D1
DE60009661D1 DE60009661T DE60009661T DE60009661D1 DE 60009661 D1 DE60009661 D1 DE 60009661D1 DE 60009661 T DE60009661 T DE 60009661T DE 60009661 T DE60009661 T DE 60009661T DE 60009661 D1 DE60009661 D1 DE 60009661D1
Authority
DE
Germany
Prior art keywords
state
bound
macromolecular component
sensor molecule
molecule
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60009661T
Other languages
English (en)
Inventor
Philippe Igor Henri Bastiaens
Peter Joseph Jacques Parker
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cancer Research Technology Ltd
Original Assignee
Cancer Research Technology Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cancer Research Technology Ltd filed Critical Cancer Research Technology Ltd
Application granted granted Critical
Publication of DE60009661D1 publication Critical patent/DE60009661D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/92—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving lipids, e.g. cholesterol, lipoproteins, or their receptors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/536—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
    • G01N33/542—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with steric inhibition or signal modification, e.g. fluorescent quenching
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/43504—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from invertebrates
    • G01N2333/43595—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from invertebrates from coelenteratae, e.g. medusae

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Biophysics (AREA)
  • Endocrinology (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analyzing Materials By The Use Of Fluid Adsorption Or Reactions (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
  • Burglar Alarm Systems (AREA)
  • Investigating Or Analyzing Materials Using Thermal Means (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
DE60009661T 1999-01-19 2000-01-19 Methode zum nachweis von veränderungen zellulärer komponenten Expired - Lifetime DE60009661D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9901072.0A GB9901072D0 (en) 1999-01-19 1999-01-19 Methods for detecting changes to a macromolecular component of a cell
PCT/GB2000/000118 WO2000043780A1 (en) 1999-01-19 2000-01-19 Methods for detecting changes to cellular components

Publications (1)

Publication Number Publication Date
DE60009661D1 true DE60009661D1 (de) 2004-05-13

Family

ID=10846082

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60009661T Expired - Lifetime DE60009661D1 (de) 1999-01-19 2000-01-19 Methode zum nachweis von veränderungen zellulärer komponenten

Country Status (7)

Country Link
EP (1) EP1145004B1 (de)
JP (1) JP2002535655A (de)
AT (1) ATE263971T1 (de)
AU (1) AU3062300A (de)
DE (1) DE60009661D1 (de)
GB (1) GB9901072D0 (de)
WO (1) WO2000043780A1 (de)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0007915D0 (en) * 2000-03-31 2000-05-17 Univ Bristol Protein kinase assay
AU2001294872A1 (en) * 2000-09-28 2002-04-08 Cellomics, Inc. Methods and reagents for live-cell gene expression quantification
AT410601B (de) * 2000-12-29 2003-06-25 Hoffmann La Roche Sensor zur lumineszenz-optischen bestimmung eines analyten sowie reagens, das nach dem fret-prinzip arbeitet
WO2002077623A1 (en) * 2001-03-23 2002-10-03 Japan Science And Technology Corporation Probe for visualizing phosphorylation/dephosphorylation of protein and method of detecting and quantifying phosphorylation/dephosphorylation of protein
FR2826666B1 (fr) * 2001-07-02 2004-07-02 Novaleads Procede de selection d'agents bio-actifs par couplage de luminescence et systeme cellulaire vivant pour la mise en oeuvre de ce procede
ATE446511T1 (de) 2001-08-01 2009-11-15 Cellomics Inc Neue fusionsproteine und molekulare bindungsassays
WO2003029796A1 (en) * 2001-09-28 2003-04-10 Ciencia, Incorporated Method to improve sensitivity of molecular binding assays using phase-sensitive luminescence detection
GB0208989D0 (en) * 2002-04-19 2002-05-29 Amersham Biosciences Uk Ltd Methods for measuring enzyme activity
US7576862B2 (en) 2003-08-26 2009-08-18 Blueshift Biotechnologies, Inc. Measuring time dependent fluorescence
JP4887154B2 (ja) 2003-10-21 2012-02-29 オリオン ゲノミクス エルエルシー Ｄｎａ座におけるメチル化密度の定量的測定の方法
US7141378B2 (en) 2004-07-02 2006-11-28 Blueshift Biotechnologies, Inc. Exploring fluorophore microenvironments
JP2009520462A (ja) * 2005-11-16 2009-05-28 カーネギー インスチチューション オブ ワシントン 多量体バイオセンサーおよびそれを用いる方法
BRPI0717416A2 (pt) 2006-09-21 2013-11-12 Prometheus Lab Inc Método para realizar um imunoensaio complexo de alta produtividade, e, arranjo
EP2087355B1 (de) * 2006-11-27 2014-09-24 Cisbio Bioassays Verfahren zum nachweis posttranslationaler modifikationen
US8828666B2 (en) 2007-06-18 2014-09-09 Chugai Seiyaku Kabushiki Kaisha Method for measuring bonding activity of antibody which mimics antibody-dependent cell medicated cytotoxic activity
JP5352585B2 (ja) 2007-07-13 2013-11-27 ネステク ソシエテ アノニム 抗体アレイを用いた肺癌治療のための薬剤選択
KR101152615B1 (ko) * 2007-08-30 2012-06-07 미쯔이 죠센 가부시키가이샤 형광공명에너지이동 검출 방법 및 장치
WO2009108637A1 (en) 2008-02-25 2009-09-03 Prometheus Laboratories, Inc. Drug selection for breast cancer therapy using antibody-based arrays
AU2010273319B2 (en) 2009-07-15 2015-01-22 Nestec S.A. Drug selection for gastric cancer therapy using antibody-based arrays
US8950687B2 (en) 2010-09-21 2015-02-10 Honeywell International Inc. Remote control of an HVAC system that uses a common temperature setpoint for both heat and cool modes
US9719995B2 (en) 2011-02-03 2017-08-01 Pierian Holdings, Inc. Drug selection for colorectal cancer therapy using receptor tyrosine kinase profiling
JP6186575B2 (ja) 2011-09-02 2017-08-30 ダイアテック ホールディングス， インコーポレイテッドＤｉａＴｅｃｈ Ｈｏｌｄｉｎｇｓ， Ｉｎｃ． 治療有効性を判定するためのシグナル経路タンパク質のプロファイリング
JP7080813B2 (ja) * 2015-12-10 2022-06-06 シティ・オブ・ホープ 細胞透過性のシアニド結合抗体

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1179600B1 (de) * 1996-06-04 2005-05-11 University Of Utah Research Foundation Überwachung der Hybridisierung während PCR
DE69804446T3 (de) * 1997-04-07 2006-08-24 Bioimage A/S Verfahren um quantitativen informationen über einflüsse auf zelluläre reaktionen zu entnehmen

Also Published As

Publication number Publication date
WO2000043780A1 (en) 2000-07-27
EP1145004A1 (de) 2001-10-17
ATE263971T1 (de) 2004-04-15
EP1145004B1 (de) 2004-04-07
JP2002535655A (ja) 2002-10-22
GB9901072D0 (en) 1999-03-10
AU3062300A (en) 2000-08-07

Similar Documents

Publication Publication Date Title
DE60009661D1 (de) Methode zum nachweis von veränderungen zellulärer komponenten
ATE412050T1 (de) Fluoreszenzprotein-sensoren zur erkennung von analyten
ATE555387T1 (de) Tests der molekularen oder subzellulären nähe unter verwendung von depolarisierung nach resonanzenergietransfer (daret)
DE69716454D1 (de) Nachweisverfahren mit hilfe von fluoreszent-energietransferliganden auf lipidfilmen
DE69833378D1 (de) Fluoreszierende polarisation
WO2002044720A3 (en) Membrane molecule indicator compositions and methods
TW200704778A (en) Screening using polarization anisotropy in fret emissions
WO2005029033A3 (en) Cyanide sensing compounds and uses thereof
ATE490466T1 (de) Als interne funktionskontrolle in tests zum nachweis von seltenen zellen verwendete markierte zellen
DE60038127D1 (de) Methoden und syteme zur überwachung intrazellulärer bindereaktionen
EP1624071A3 (de) Nachweisverfahren für lebenfähige Zellen
DK0716740T3 (da) Fremgangsmåde til aktivering af polyanioniske, fluorescerende farvestoffer i medier med lav dielektricitet ved hjælp af kvaternære oniumforbindelser
WO2003040670A3 (en) Method of identifying energy transfer sensors for analytes
EP2221385A3 (de) Deubiquinations-Assays
CA2397545A1 (en) Method of detecting dna by dna hybridization method with the use of fluorescent resonance energy transfer
ATE533053T1 (de) Nicht-elispot-test
ATE405837T1 (de) Festphase immunochromatographische testverfahren
EP1138781A3 (de) Methode zur Quantifizierung der Bindeaktivität von DNA-bindenden Proteinen
WO2007016495A3 (en) Fluorescent sensors for cellular amines
ATE466884T1 (de) Holo-transcobalamin bindungspartner und ihre verwendung in cobalamintest
EP1076240A4 (de) Verfahren zum bestimmen von crp mit hilfe von phosphorylcholin
DE50113987D1 (de) Verfahren zum Nachweis biologischer Moleküle
DE59907982D1 (de) Verfahren zum Nachweis einer bei Apoptose aktivierten Protease
WO2006101520A3 (en) Fluorescent proteins and related methods and compounds
DE69930843D1 (de) Verfahren zum bestimmen von autoantikörpern

Legal Events

Date Code Title Description
8332 No legal effect for de