ATE555387T1 - Tests der molekularen oder subzellulären nähe unter verwendung von depolarisierung nach resonanzenergietransfer (daret) - Google Patents

Tests der molekularen oder subzellulären nähe unter verwendung von depolarisierung nach resonanzenergietransfer (daret)

Info

Publication number
ATE555387T1
ATE555387T1 AT09010300T AT09010300T ATE555387T1 AT E555387 T1 ATE555387 T1 AT E555387T1 AT 09010300 T AT09010300 T AT 09010300T AT 09010300 T AT09010300 T AT 09010300T AT E555387 T1 ATE555387 T1 AT E555387T1
Authority
AT
Austria
Prior art keywords
daret
molecular
depolarization
subcellular
energy transfer
Prior art date
Application number
AT09010300T
Other languages
English (en)
Inventor
Marcella A Gilmore
Dudley J Williams
Lance E Steward
Kei Roger Aoki
Original Assignee
Allergan Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37806796&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE555387(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Allergan Inc filed Critical Allergan Inc
Application granted granted Critical
Publication of ATE555387T1 publication Critical patent/ATE555387T1/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/536—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
    • G01N33/542—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with steric inhibition or signal modification, e.g. fluorescent quenching
AT09010300T 2005-10-12 2006-10-11 Tests der molekularen oder subzellulären nähe unter verwendung von depolarisierung nach resonanzenergietransfer (daret) ATE555387T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US72651505P 2005-10-12 2005-10-12
US11/548,411 US7998749B2 (en) 2005-10-12 2006-10-11 Assays of molecular or subcellular interactivity using depolarization after resonance transfer energy (DARET)

Publications (1)

Publication Number Publication Date
ATE555387T1 true ATE555387T1 (de) 2012-05-15

Family

ID=37806796

Family Applications (2)

Application Number Title Priority Date Filing Date
AT09010300T ATE555387T1 (de) 2005-10-12 2006-10-11 Tests der molekularen oder subzellulären nähe unter verwendung von depolarisierung nach resonanzenergietransfer (daret)
AT06816778T ATE456798T1 (de) 2005-10-12 2006-10-11 Tests der molekularen oder subzellulären interaktivität unter verwendung von depolarisierung nach resonanzenergietransfer (daret)

Family Applications After (1)

Application Number Title Priority Date Filing Date
AT06816778T ATE456798T1 (de) 2005-10-12 2006-10-11 Tests der molekularen oder subzellulären interaktivität unter verwendung von depolarisierung nach resonanzenergietransfer (daret)

Country Status (9)

Country Link
US (1) US7998749B2 (de)
EP (2) EP2131195B1 (de)
JP (2) JP2009521666A (de)
AT (2) ATE555387T1 (de)
AU (1) AU2006304151B2 (de)
CA (1) CA2602972C (de)
DE (1) DE602006012072D1 (de)
ES (1) ES2338368T3 (de)
WO (1) WO2007047342A1 (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9617671D0 (en) * 1996-08-23 1996-10-02 Microbiological Res Authority Recombinant toxin fragments
US7332567B2 (en) * 2001-08-28 2008-02-19 Allergan, Inc. Fret protease assays for clostridial toxins
US20080064054A1 (en) * 2001-08-28 2008-03-13 Ester Fernandez-Salas Fluorescence resonance energy transfer (fret) assays for clostridial toxin activity
US7208285B2 (en) * 2001-08-28 2007-04-24 Allergan, Inc. Fret protease assays for botulinum serotype A/E toxins
US7374896B2 (en) * 2001-08-28 2008-05-20 Allergan, Inc. GFP-SNAP25 fluorescence release assay for botulinum neurotoxin protease activity
US7183066B2 (en) * 2002-09-27 2007-02-27 Allergan, Inc. Cell-based fluorescence resonance energy transfer (FRET) assays for clostridial toxins
US7399607B2 (en) * 2004-09-22 2008-07-15 Allergan, Inc. Fluorescence polarization assays for determining clostridial toxin activity
US8999666B2 (en) * 2006-08-09 2015-04-07 Intrexon Corporation PKC ligands and polynucleotides encoding PKC ligands
JP5412689B2 (ja) 2007-09-14 2014-02-12 バイオマデイソン・インコーポレイテツド 切断配列とスペーサーを用いた共鳴エネルギー転移アッセイ
KR101604515B1 (ko) * 2008-03-14 2016-03-17 알러간, 인코포레이티드 면역-기반 보툴리눔 독소 세로타입 ａ 활성 검정
BR122012027456A2 (pt) 2008-03-14 2015-07-14 Allergan Inc Composição farmacêutica compreendendo sorotipo de neurotoxina botulínica a
US8993715B2 (en) 2009-07-06 2015-03-31 Canon Kabushiki Kaisha Labeled protein and method for obtaining the same
US20110312709A1 (en) * 2010-06-17 2011-12-22 Geneasys Pty Ltd Loc device for detecting target nucleic acid sequences using electrochemiluminescent probes and calibration probes with detection photosensors and calibration photosensors
EP3279335B1 (de) 2011-12-31 2021-03-10 Allergan, Inc. Hochempfindlicher zellbasierter test für den nachweis der anwesenheit von aktivem botulinum-neurotoxin-serotyp-a
CN105996968A (zh) * 2016-05-09 2016-10-12 南京琦光光电科技有限公司 医疗内窥镜用led光源及光谱设计方法

Family Cites Families (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4211762A (en) 1978-01-26 1980-07-08 Huggins Keith G Specific binding assay techniques
EP0051985B2 (de) 1980-11-07 1989-12-27 International Institute Of Cellular And Molecular Pathology (Icp) Immunologischer Test von Proteinen
US4680258A (en) 1981-03-24 1987-07-14 Sloan-Kettering Institute For Cancer Research Process for sex determination in man by use of monoclonal antibodies to the H-Y antigen
US4427783A (en) 1981-12-14 1984-01-24 Hoffmann-La Roche Inc. Immunoassay of thymosin α1
US4628027A (en) 1982-05-19 1986-12-09 Molecular Engineering Associates, Ltd. Vitro diagnostic methods using monoclonal antibodies against connective tissue proteins
US4659678A (en) 1982-09-29 1987-04-21 Serono Diagnostics Limited Immunoassay of antigens
CA2001774C (en) 1988-10-28 2001-10-16 James A. Wells Method for identifying active domains and amino acid residues in polypeptides and hormone variants
GB9310978D0 (en) 1993-05-27 1993-07-14 Zeneca Ltd Compounds
US5962637A (en) 1994-06-03 1999-10-05 Microbiological Research Authority Toxin assay
US5661035A (en) 1995-06-07 1997-08-26 The Regents Of The University Of California Voltage sensing by fluorescence resonance energy transfer
US6596522B2 (en) 1997-05-08 2003-07-22 The Regents Of The University Of California Detection of transmembrane potentials by optical methods
US6342379B1 (en) 1995-06-07 2002-01-29 The Regents Of The University Of California Detection of transmembrane potentials by optical methods
US6358709B1 (en) * 1995-12-07 2002-03-19 Diversa Corporation End selection in directed evolution
US6803188B1 (en) * 1996-01-31 2004-10-12 The Regents Of The University Of California Tandem fluorescent protein constructs
ATE317122T1 (de) 1997-09-05 2006-02-15 Matsushita Electric Ind Co Ltd Fluoreszierende polarisation
US6444421B1 (en) 1997-11-19 2002-09-03 The United States Of America As Represented By The Department Of Health And Human Services Methods for detecting intermolecular interactions in vivo and in vitro
US7101681B1 (en) 1997-11-21 2006-09-05 Amgen, Inc. Nuclear hormone receptor drug screens
US6207392B1 (en) 1997-11-25 2001-03-27 The Regents Of The University Of California Semiconductor nanocrystal probes for biological applications and process for making and using such probes
CA2336985C (en) 1998-07-17 2011-01-04 University Of Maryland, Baltimore Method of glucose or galactose detection with glucose/galactose binding protein
DE19860833C1 (de) 1998-12-30 2000-09-07 Albrecht E Sippel Methode zur zellulären High-Throughput(Hochdurchsatz)-Detektion von Rezeptor-Liganden-Interaktionen
AU2849800A (en) * 1999-01-15 2000-08-01 Ljl Biosystems, Inc. Methods and apparatus for detecting polynucleotide hybridization
US6972198B2 (en) 1999-02-26 2005-12-06 Cyclacel, Ltd. Methods and compositions using protein binding partners
JP2000333681A (ja) * 1999-05-27 2000-12-05 Nec Corp タンパク質分解酵素切断配列を含有するタンパク質分解酵素用基質及びその発現用ベクター
AU5849500A (en) 1999-07-08 2001-01-30 Fujisawa Pharmaceutical Co., Ltd. Apoptosis-associated factor
US6325899B1 (en) 2000-03-10 2001-12-04 Action Caps, Llc Disposable and recyclable intermediates for use in electrostatic coating processes
EP1195604A1 (de) 2000-09-29 2002-04-10 Warner-Lambert Company Verfahren und Zusammensetzungen zum Screenen von Modulatoren von Lipidkinasen
US7332567B2 (en) 2001-08-28 2008-02-19 Allergan, Inc. Fret protease assays for clostridial toxins
US7374896B2 (en) 2001-08-28 2008-05-20 Allergan, Inc. GFP-SNAP25 fluorescence release assay for botulinum neurotoxin protease activity
US20080064054A1 (en) 2001-08-28 2008-03-13 Ester Fernandez-Salas Fluorescence resonance energy transfer (fret) assays for clostridial toxin activity
US8022172B2 (en) 2001-08-28 2011-09-20 Allergan, Inc. Luminescence resonance energy transfer (LRET) assays for clostridial toxin activity
US7208285B2 (en) 2001-08-28 2007-04-24 Allergan, Inc. Fret protease assays for botulinum serotype A/E toxins
AU2002363530A1 (en) * 2001-11-07 2003-05-19 Sensor Technologies Llc Method of identifying energy transfer sensors for analytes
AU2002357002A1 (en) * 2001-12-17 2003-06-30 Powderject Research Limited Diagnostic sensing apparatus
US6942987B2 (en) * 2002-05-15 2005-09-13 Pharmacopeia Drug Discovery, Inc. Methods for measuring kinase activity
US6713262B2 (en) 2002-06-25 2004-03-30 Agilent Technologies, Inc. Methods and compositions for high throughput identification of protein/nucleic acid binding pairs
US7183066B2 (en) 2002-09-27 2007-02-27 Allergan, Inc. Cell-based fluorescence resonance energy transfer (FRET) assays for clostridial toxins
JP4214206B2 (ja) * 2002-12-10 2009-01-28 独立行政法人理化学研究所 Ｆｒｅｔを利用した蛍光指示薬
US6969196B2 (en) * 2003-03-07 2005-11-29 Exopack-Technology, Llc Bag having reclosable seal and associated methods
JP2005017282A (ja) * 2003-05-30 2005-01-20 Olympus Corp 受光ユニットおよびそれを含む測定装置
US7408640B2 (en) 2003-11-05 2008-08-05 The United States Of America As Represented By The Secretary Of The Navy Fluorescence polarization instruments and methods for detection of exposure to biological materials by fluorescence polarization immunoassay of saliva, oral or bodily fluids
CA2550401C (en) * 2003-12-19 2015-12-08 Wisconsin Alumni Research Foundation Method and compositions for detecting botulinum neurotoxin
EP1718756B1 (de) * 2004-02-24 2011-11-16 Allergan, Inc. Botulinumtoxin-screening-assays
US7399607B2 (en) 2004-09-22 2008-07-15 Allergan, Inc. Fluorescence polarization assays for determining clostridial toxin activity
ATE470857T1 (de) 2005-04-05 2010-06-15 Allergan Inc Lipophile, farbstoffbasierte fret-assays für die clostridientoxinaktivität

Also Published As

Publication number Publication date
AU2006304151A1 (en) 2007-04-26
EP2131195B1 (de) 2012-04-25
ATE456798T1 (de) 2010-02-15
US20070275477A1 (en) 2007-11-29
JP2013174595A (ja) 2013-09-05
EP2131195A1 (de) 2009-12-09
EP1934610A1 (de) 2008-06-25
WO2007047342A1 (en) 2007-04-26
AU2006304151B2 (en) 2012-01-19
CA2602972A1 (en) 2007-04-26
JP2009521666A (ja) 2009-06-04
ES2338368T3 (es) 2010-05-06
US7998749B2 (en) 2011-08-16
EP1934610B1 (de) 2010-01-27
CA2602972C (en) 2013-09-24
DE602006012072D1 (de) 2010-03-18

Similar Documents

Publication Publication Date Title
ATE555387T1 (de) Tests der molekularen oder subzellulären nähe unter verwendung von depolarisierung nach resonanzenergietransfer (daret)
ATE394677T1 (de) Fret proben und verfahren zur erkennung aufeinander einwirkeneden moleküle
DE602005000485D1 (de) Nukleinsäurenachweisverfahren mittels mehreren Paaren von Donorflurophoren und Quenchemolekülen in derselben Sonde
DE60009661D1 (de) Methode zum nachweis von veränderungen zellulärer komponenten
DE602005024238D1 (de) Fluorometer mit auswechselbarer spitze und offener zelle
DE602008006382D1 (de) Pyridin-boronsäure-quencher zur verwendung in analytsensoren
ATE490466T1 (de) Als interne funktionskontrolle in tests zum nachweis von seltenen zellen verwendete markierte zellen
ATE430750T1 (de) Kondensierte 4-5-diamino-n,n-dihydro-pyrazol-3-on-derivate und deren verwendung als färbemittel für keratinfasern
ATE431427T1 (de) Verbessertes verfahren zum nachweis von atp
CY1112090T1 (el) Μεθοδος για ανιχνευση βιολογικων οργανισμων με χρηση σκεδασης raman
ATE428929T1 (de) Reagens, ausstattung und verfahren zur probenanalyse
CY1107021T1 (el) Μεθοδος προσδιορισμου της ποσοτητας εκμαγειου νουκλεϊνικου οξεος που υπαρχει σε ενα δειγμα
DE602005025043D1 (de) Saccharose-biosensoren und verwendungsverfahren dafür
WO2007028921A3 (fr) Methode de detection d'interaction intracellulaire entre bio-molecules
ATE458200T1 (de) Anwendungen des resonanzenergietransfers zwischen terbium und gfp
ATE519116T1 (de) Verfahren zur normierung der konzentration von analyten in einer urinprobe
ATE529533T1 (de) Verfahren zum nachweis von analyten in einer probe
CA2725963A1 (en) Screening methods for heat-shock response modulators
ATE540048T1 (de) Neurotransmittersensoren und verfahren zu ihrer verwendung
DE60301821D1 (de) Küvette für ein Lesegerät zur Bestimmung von Substanzen mittels der Evaneszenzfeldmethode
ATE437239T1 (de) Induktion der mitochondrialen permeabilitätstransition
DK1370863T3 (da) Patch-clamp-fremgangsmåde og anvendelse af denne ved analyse af subcellulære træk
WO2007016495A3 (en) Fluorescent sensors for cellular amines
ATE533053T1 (de) Nicht-elispot-test
ATE481412T1 (de) Phosphat-biosensoren und verfahren zu deren anwendung