JP6861166B2 - サイクリン依存性キナーゼの阻害剤 - Google Patents

サイクリン依存性キナーゼの阻害剤 Download PDF

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Publication number
JP6861166B2
JP6861166B2 JP2017550748A JP2017550748A JP6861166B2 JP 6861166 B2 JP6861166 B2 JP 6861166B2 JP 2017550748 A JP2017550748 A JP 2017550748A JP 2017550748 A JP2017550748 A JP 2017550748A JP 6861166 B2 JP6861166 B2 JP 6861166B2
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alkyl
optionally substituted
substituted
carbamate
ring
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Japanese (ja)
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JP2018515434A5 (OSRAM
JP2018515434A (ja
Inventor
グレイ，ナサニエル，エス．
チャン，ティンフー
クウィアトコウスキ，ニコラス，ポール
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Dana Farber Cancer Institute Inc
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Dana Farber Cancer Institute Inc
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Priority to JP2021054539A priority Critical patent/JP7200282B2/ja
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Priority to JP2022204259A priority patent/JP2023052006A/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/16—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32—Nitrogen atom
    • C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4738—Cell cycle regulated proteins, e.g. cyclin, CDC, INK-CCR

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Genetics & Genomics (AREA)
  • Cell Biology (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2017550748A 2015-03-27 2016-03-25 サイクリン依存性キナーゼの阻害剤 Active JP6861166B2 (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2021054539A JP7200282B2 (ja) 2015-03-27 2021-03-29 サイクリン依存性キナーゼの阻害剤
JP2022204259A JP2023052006A (ja) 2015-03-27 2022-12-21 サイクリン依存性キナーゼの阻害剤

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562139352P 2015-03-27 2015-03-27
US62/139,352 2015-03-27
PCT/US2016/024345 WO2016160617A2 (en) 2015-03-27 2016-03-25 Inhibitors of cyclin-dependent kinases

Related Child Applications (1)

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JP2021054539A Division JP7200282B2 (ja) 2015-03-27 2021-03-29 サイクリン依存性キナーゼの阻害剤

Publications (3)

Publication Number Publication Date
JP2018515434A JP2018515434A (ja) 2018-06-14
JP2018515434A5 JP2018515434A5 (OSRAM) 2019-05-09
JP6861166B2 true JP6861166B2 (ja) 2021-04-21

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JP2017550748A Active JP6861166B2 (ja) 2015-03-27 2016-03-25 サイクリン依存性キナーゼの阻害剤
JP2021054539A Active JP7200282B2 (ja) 2015-03-27 2021-03-29 サイクリン依存性キナーゼの阻害剤
JP2022204259A Pending JP2023052006A (ja) 2015-03-27 2022-12-21 サイクリン依存性キナーゼの阻害剤

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JP2021054539A Active JP7200282B2 (ja) 2015-03-27 2021-03-29 サイクリン依存性キナーゼの阻害剤
JP2022204259A Pending JP2023052006A (ja) 2015-03-27 2022-12-21 サイクリン依存性キナーゼの阻害剤

Country Status (8)

Country Link
US (3) US10550121B2 (OSRAM)
EP (1) EP3273966B1 (OSRAM)
JP (3) JP6861166B2 (OSRAM)
CN (1) CN107427521B (OSRAM)
AU (1) AU2016243529B2 (OSRAM)
CA (1) CA2978518C (OSRAM)
HK (1) HK1246645A1 (OSRAM)
WO (1) WO2016160617A2 (OSRAM)

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