JP6756925B2 - ヒストンデアセチラーゼの二環式阻害剤 - Google Patents

ヒストンデアセチラーゼの二環式阻害剤 Download PDF

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JP6756925B2
JP6756925B2 JP2019537829A JP2019537829A JP6756925B2 JP 6756925 B2 JP6756925 B2 JP 6756925B2 JP 2019537829 A JP2019537829 A JP 2019537829A JP 2019537829 A JP2019537829 A JP 2019537829A JP 6756925 B2 JP6756925 B2 JP 6756925B2
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compound
disease
disorder
pharmaceutically acceptable
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JP2020504156A5 (https=
JP2020504156A (ja
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フラー，ネイサン・オリバー
ロウ，ジョン・エイ，ザ・サード
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ロダン・セラピューティクス，インコーポレーテッド
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
JP2019537829A 2017-01-11 2018-01-11 ヒストンデアセチラーゼの二環式阻害剤 Expired - Fee Related JP6756925B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201762445022P 2017-01-11 2017-01-11
US62/445,022 2017-01-11
US201762555298P 2017-09-07 2017-09-07
US62/555,298 2017-09-07
PCT/US2018/013260 WO2018132531A1 (en) 2017-01-11 2018-01-11 Bicyclic inhibitors of histone deacetylase

Publications (3)

Publication Number Publication Date
JP2020504156A JP2020504156A (ja) 2020-02-06
JP2020504156A5 JP2020504156A5 (https=) 2020-07-30
JP6756925B2 true JP6756925B2 (ja) 2020-09-16

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US (7) US9951069B1 (https=)
EP (2) EP3570834B1 (https=)
JP (1) JP6756925B2 (https=)
KR (1) KR102526032B1 (https=)
CN (1) CN110290789B (https=)
AU (1) AU2018207402B2 (https=)
BR (1) BR112019014235A2 (https=)
CA (1) CA3049443A1 (https=)
CY (1) CY1125287T1 (https=)
DK (1) DK3570834T3 (https=)
ES (2) ES2875562T3 (https=)
HR (1) HRP20220223T1 (https=)
HU (1) HUE057849T2 (https=)
IL (1) IL267953B2 (https=)
LT (1) LT3570834T (https=)
MA (1) MA47305A (https=)
MD (1) MD3570834T2 (https=)
MX (1) MX394242B (https=)
PL (1) PL3570834T3 (https=)
PT (1) PT3570834T (https=)
RS (1) RS62959B1 (https=)
SG (1) SG11201906164RA (https=)
SI (1) SI3570834T1 (https=)
SM (1) SMT202200131T1 (https=)
TW (1) TWI770104B (https=)
WO (2) WO2018132531A1 (https=)
ZA (1) ZA201904459B (https=)

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LT3319959T (lt) * 2015-07-06 2021-12-27 Alkermes, Inc. Histono deacetilazės hetero-halogeno inhibitoriai
RS62959B1 (sr) 2017-01-11 2022-03-31 Alkermes Inc Biciklični inhibitori histon-deacetilaze
US11225475B2 (en) * 2017-08-07 2022-01-18 Alkermes, Inc. Substituted pyridines as inhibitors of histone deacetylase
EP3982968A4 (en) * 2019-06-13 2023-07-05 Dana-Farber Cancer Institute, Inc. DEVELOPMENT OF HDAC3 CATALYTIC INHIBITOR AND USES THEREOF
WO2021016413A1 (en) 2019-07-23 2021-01-28 Alkermes, Inc. Synthesis of bicyclic inhibitors of histone deacetylase
CN110734924B (zh) * 2019-10-25 2020-10-23 山东大学第二医院 一种抑郁症检测、治疗和预后靶点及应用
IL313081A (en) 2021-12-03 2024-07-01 Tango Therapeutics Inc New HDAC inhibitors and their medical use

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