JP5198430B2 - ａｎｔｉｍｉＲＮＡアンチセンスオリゴヌクレオチドを含む医薬組成物 - Google Patents

ａｎｔｉｍｉＲＮＡアンチセンスオリゴヌクレオチドを含む医薬組成物 Download PDF

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JP5198430B2
JP5198430B2 JP2009503410A JP2009503410A JP5198430B2 JP 5198430 B2 JP5198430 B2 JP 5198430B2 JP 2009503410 A JP2009503410 A JP 2009503410A JP 2009503410 A JP2009503410 A JP 2009503410A JP 5198430 B2 JP5198430 B2 JP 5198430B2
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lna
oligonucleotide
xxxxxx
mir
units
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JP2009532044A5 (https=
JP2009532044A (ja
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ヨアヒム・エルメン
フィル・カーニー
サカリ・カウッピネン
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Roche Innovation Center Copenhagen AS
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Santaris Pharma AS
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JP2009503410A 2006-04-03 2007-03-30 ａｎｔｉｍｉＲＮＡアンチセンスオリゴヌクレオチドを含む医薬組成物 Expired - Fee Related JP5198430B2 (ja)

Applications Claiming Priority (13)

Application Number Priority Date Filing Date Title
US78899506P 2006-04-03 2006-04-03
DKPA200600478 2006-04-03
DKPA200600478 2006-04-03
US60/788,995 2006-04-03
US79681306P 2006-05-01 2006-05-01
US60/796,813 2006-05-01
DKPA200600615 2006-05-01
DKPA200600615 2006-05-01
US83871006P 2006-08-18 2006-08-18
US60/838,710 2006-08-18
DKPA200601401 2006-10-30
DKPA200601401 2006-10-30
PCT/DK2007/000168 WO2007112753A2 (en) 2006-04-03 2007-03-30 Pharmaceutical composition comprising anti-mirna antisense oligonucleotides

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JP2012242996A Division JP2013078317A (ja) 2006-04-03 2012-11-02 ａｎｔｉｍｉＲＮＡアンチセンスオリゴヌクレオチドを含む医薬組成物

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JP2009532044A JP2009532044A (ja) 2009-09-10
JP2009532044A5 JP2009532044A5 (https=) 2010-06-03
JP5198430B2 true JP5198430B2 (ja) 2013-05-15

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JP2009503410A Expired - Fee Related JP5198430B2 (ja) 2006-04-03 2007-03-30 ａｎｔｉｍｉＲＮＡアンチセンスオリゴヌクレオチドを含む医薬組成物
JP2009503411A Expired - Fee Related JP5814505B2 (ja) 2006-04-03 2007-03-30 ａｎｔｉｍｉＲＮＡアンチセンスオリゴヌクレオチドを含む医薬組成物
JP2012242996A Pending JP2013078317A (ja) 2006-04-03 2012-11-02 ａｎｔｉｍｉＲＮＡアンチセンスオリゴヌクレオチドを含む医薬組成物
JP2014022650A Expired - Fee Related JP5872603B2 (ja) 2006-04-03 2014-02-07 ａｎｔｉｍｉＲＮＡアンチセンスオリゴヌクレオチドを含む医薬組成物
JP2015221396A Expired - Fee Related JP6326025B2 (ja) 2006-04-03 2015-11-11 ａｎｔｉｍｉＲＮＡアンチセンスオリゴヌクレオチドを含む医薬組成物

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JP2009503411A Expired - Fee Related JP5814505B2 (ja) 2006-04-03 2007-03-30 ａｎｔｉｍｉＲＮＡアンチセンスオリゴヌクレオチドを含む医薬組成物
JP2012242996A Pending JP2013078317A (ja) 2006-04-03 2012-11-02 ａｎｔｉｍｉＲＮＡアンチセンスオリゴヌクレオチドを含む医薬組成物
JP2014022650A Expired - Fee Related JP5872603B2 (ja) 2006-04-03 2014-02-07 ａｎｔｉｍｉＲＮＡアンチセンスオリゴヌクレオチドを含む医薬組成物
JP2015221396A Expired - Fee Related JP6326025B2 (ja) 2006-04-03 2015-11-11 ａｎｔｉｍｉＲＮＡアンチセンスオリゴヌクレオチドを含む医薬組成物

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US (8) US20100004320A1 (https=)
EP (3) EP2007888A2 (https=)
JP (5) JP5198430B2 (https=)
KR (1) KR101407707B1 (https=)
AU (1) AU2007234191B2 (https=)
CA (4) CA3024953A1 (https=)
DK (1) DK2666859T3 (https=)
EA (1) EA015570B1 (https=)
ES (1) ES2715625T3 (https=)
IL (1) IL194007A0 (https=)
MX (1) MX2008012219A (https=)
WO (2) WO2007112754A2 (https=)

Cited By (3)

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US10612021B2 (en) 2015-10-07 2020-04-07 Kyoto University Therapeutic or prophylactic composition for TDP-43 proteinopathy
US11584932B2 (en) 2016-11-01 2023-02-21 The Research Foundation For The State University Of New York 5-halouracil-modified microRNAs and their use in the treatment of cancer
US12319913B2 (en) 2018-10-31 2025-06-03 The Research Foundation For The State University Of New York 5-halouracil-modified microRNAs and their use in the treatment of cancer

Families Citing this family (264)

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US8969314B2 (en) 2003-07-31 2015-03-03 Regulus Therapeutics, Inc. Methods for use in modulating miR-122a
ES2361458T5 (es) 2004-05-04 2016-04-20 The Board Of Trustees Of The Leland Stanford Junior University Procedimientos y composiciones para reducir las cantidades de genoma vírico de VHC en una célula diana
EP1877557A2 (en) 2005-04-04 2008-01-16 The Board of Regents of The University of Texas System Micro-rna's that regulate muscle cells
CN103820562B (zh) 2005-08-01 2015-05-13 俄亥俄州立大学研究基金会 用于乳腺癌的诊断、预后和治疗的基于MicroRNA的方法和组合物
JP2009507918A (ja) 2005-09-12 2009-02-26 ジ・オハイオ・ステイト・ユニバーシティ・リサーチ・ファウンデイション Ｂｃｌ２関連癌の診断及び療法のための組成物及び方法
US7670840B2 (en) 2006-01-05 2010-03-02 The Ohio State University Research Foundation Micro-RNA expression abnormalities of pancreatic, endocrine and acinar tumors
ES2553442T3 (es) 2006-01-05 2015-12-09 The Ohio State University Research Foundation Procedimientos basados en los microARN para el diagnóstico, pronóstico y tratamiento del cáncer de pulmón
EP1969147B1 (en) 2006-01-05 2014-07-30 The Ohio State University Research Foundation microRNA-based methods for the diagnosis of stomach cancer
EP2369011A1 (en) 2006-03-20 2011-09-28 The Ohio State University Research Foundation Microrna fingerprints during human megakaryocytopoiesis
SG10201406016SA (en) 2006-04-03 2014-11-27 Stella Aps Pharmaceutical composition comprising anti-mirna antisense oligonucleotides
EP2007888A2 (en) 2006-04-03 2008-12-31 Santaris Pharma A/S Pharmaceutical composition comprising anti-mirna antisense oligonucleotides
JP2009536222A (ja) 2006-05-05 2009-10-08 アイシス ファーマシューティカルズ， インコーポレーテッド Ｐｃｓｋ９の発現を調節するための化合物および方法
EP2041317A4 (en) 2006-07-13 2009-10-14 Univ Ohio State Res Found METHODS AND COMPOSITIONS BASED ON MICRO-RNA FOR THE DIAGNOSIS AND TREATMENT OF COLON CANCER RELATED DISEASES
AU2007281261B2 (en) 2006-08-01 2013-03-21 Board Of Regents Of The University Of Texas System Identification of a micro-RNA that activates expression of beta-myosin heavy chain
US8188255B2 (en) 2006-10-20 2012-05-29 Exiqon A/S Human microRNAs associated with cancer
EP2090665A2 (en) 2006-10-20 2009-08-19 Exiqon A/S Novel human microRNAs associated with cancer
AU2007323469B2 (en) 2006-11-23 2014-07-24 Guangdong Maijinjia Biotechnology Co., Ltd Oligonucleotides for modulating target RNA activity
WO2008094545A2 (en) 2007-01-31 2008-08-07 The Ohio State University Research Foundation Mic orna-based methods and compositions for the treatment of acute myeloid leukemia
US8470791B2 (en) 2007-03-22 2013-06-25 Santaris Pharma A/S RNA antagonist compounds for the inhibition of Apo-B100 expression
DK2149605T3 (da) 2007-03-22 2013-09-30 Santaris Pharma As Korte RNA antagonist forbindelser til modulering af det ønskede mRNA
US8288358B2 (en) 2007-03-26 2012-10-16 Newcastle Innovation Ltd. Therapeutic targets and molecules
AU2008248319B2 (en) * 2007-04-30 2013-09-05 The Ohio State University Research Foundation Methods for differentiating pancreatic cancer from normal pancreatic function and/or chronic pancreatitis
EP2714904B1 (en) 2007-06-14 2017-04-12 Mirx Therapeutics ApS Oligonucleotides for modulation of target rna activity
CN101918424A (zh) 2007-06-15 2010-12-15 俄亥俄州立大学研究基金会 用于靶向由Drosha介导的微小RNA加工的致癌ALL-1融合蛋白
EP2182969B1 (en) 2007-07-31 2016-11-16 The Board of Regents of The University of Texas System A micro-rna family that modulates fibrosis and uses thereof
CN101809169B (zh) 2007-07-31 2013-07-17 俄亥俄州立大学研究基金会 通过靶向dnmt3a和dnmt3b恢复甲基化的方法
EP2187896B1 (en) 2007-07-31 2016-01-13 The Board of Regents of The University of Texas System Inhibitors of mir-499 and mir-208b for use in the treatment of pathologic cardiac hypertrophy, heart failure or myocardial infarction
EP2653561B1 (en) 2007-08-03 2016-03-02 The Ohio State University Research Foundation Ultraconserved regions encoding ncRNAs
EP3028708A1 (en) 2007-08-22 2016-06-08 The Ohio State University Research Foundation Methods and compositions for inducing deregulation of epha7 and erk phosphorylation in human acute leukemias
EP2623599B1 (en) 2007-10-04 2019-01-02 Roche Innovation Center Copenhagen A/S Micromirs
AU2013273821B2 (en) * 2007-10-04 2016-03-10 Roche Innovation Center Copenhagen A/S Micromirs
EP2212440A4 (en) * 2007-10-11 2011-04-06 Univ Ohio State Res Found METHOD AND COMPOSITIONS FOR DIAGNOSIS AND TREATMENT OF ADENOCARCINOMES OF DISHES
CA2703707A1 (en) 2007-10-26 2009-04-30 The Ohio State University Research Foundation Methods for identifying fragile histidine triad (fhit) interaction and uses thereof
US8211867B2 (en) * 2007-10-29 2012-07-03 Regulus Therapeutics Inc. Targeting microRNAs for the treatment of liver cancer
KR20100099158A (ko) 2007-11-09 2010-09-10 보드 오브 리전츠 더 유니버시티 오브 텍사스 시스템 심근세포 생존과 심장 회복을 제어하는 ＭＩＲ-15 집단의 마이크로ＲＮＡｓ
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