EP4103713A4 - Pan-genotypic agents against respiratory viruses and methods of using the same - Google Patents
Pan-genotypic agents against respiratory viruses and methods of using the sameInfo
- Publication number
- EP4103713A4 EP4103713A4 EP21780993.8A EP21780993A EP4103713A4 EP 4103713 A4 EP4103713 A4 EP 4103713A4 EP 21780993 A EP21780993 A EP 21780993A EP 4103713 A4 EP4103713 A4 EP 4103713A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- genotypic
- pan
- methods
- same
- agents against
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 241000700605 Viruses Species 0.000 title 1
- 230000000241 respiratory effect Effects 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1131—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/11—Antisense
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/11—Antisense
- C12N2310/113—Antisense targeting other non-coding nucleic acids, e.g. antagomirs
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/32—Chemical structure of the sugar
- C12N2310/323—Chemical structure of the sugar modified ring structure
- C12N2310/3231—Chemical structure of the sugar modified ring structure having an additional ring, e.g. LNA, ENA
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/34—Spatial arrangement of the modifications
- C12N2310/341—Gapmers, i.e. of the type ===---===
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US16/792,103 US11339392B2 (en) | 2016-03-02 | 2020-02-14 | Pan-genotypic agents against influenza virus and methods of using the same |
US202062992659P | 2020-03-20 | 2020-03-20 | |
PCT/US2021/018025 WO2021201996A1 (en) | 2020-02-14 | 2021-02-12 | Pan-genotypic agents against respiratory viruses and methods of using the same |
Publications (2)
Publication Number | Publication Date |
---|---|
EP4103713A1 EP4103713A1 (en) | 2022-12-21 |
EP4103713A4 true EP4103713A4 (en) | 2024-03-20 |
Family
ID=83688484
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP21780993.8A Pending EP4103713A4 (en) | 2020-02-14 | 2021-02-12 | Pan-genotypic agents against respiratory viruses and methods of using the same |
Country Status (4)
Country | Link |
---|---|
EP (1) | EP4103713A4 (en) |
JP (1) | JP2023514576A (en) |
CN (1) | CN115997014A (en) |
CA (1) | CA3167206A1 (en) |
-
2021
- 2021-02-12 EP EP21780993.8A patent/EP4103713A4/en active Pending
- 2021-02-12 JP JP2022548912A patent/JP2023514576A/en active Pending
- 2021-02-12 CA CA3167206A patent/CA3167206A1/en active Pending
- 2021-02-12 CN CN202180029086.9A patent/CN115997014A/en active Pending
Non-Patent Citations (4)
Title |
---|
HAGEY RACHEL J. ET AL: "Programmable antivirals targeting critical conserved viral RNA secondary structures from influenza A virus and SARS-CoV-2", NATURE MEDICINE, vol. 28, no. 9, 18 August 2022 (2022-08-18), New York, pages 1944 - 1955, XP093126274, ISSN: 1078-8956, Retrieved from the Internet <URL:https://www.nature.com/articles/s41591-022-01908-x> DOI: 10.1038/s41591-022-01908-x * |
See also references of WO2021201996A1 * |
SIMONE GIANNECCHINI ET AL: "Oligonucleotides derived from the packaging signal at the 5' end of the viral PB2 segment specifically inhibit influenza virus in vitro", ARCHIVES OF VIROLOGY ; OFFICIAL JOURNAL OF THE VIROLOGY DIVISIONOF THE INTERNATIONAL UNION OF MICROBIOLOGICAL SOCIETIES, SPRINGER-VERLAG, VI, vol. 154, no. 5, 16 April 2009 (2009-04-16), pages 821 - 832, XP019722939, ISSN: 1432-8798 * |
SIMONE GIANNECCHINI ET AL: "Packaging signals in the 5-ends of influenza virus PA, PB1, and PB2 genes as potential targets to develop nucleic-acid based antiviral molecules", ANTIVIRAL RESEARCH, ELSEVIER BV, NL, vol. 92, no. 1, 21 June 2011 (2011-06-21), pages 64 - 72, XP028293110, ISSN: 0166-3542, [retrieved on 20110629], DOI: 10.1016/J.ANTIVIRAL.2011.06.013 * |
Also Published As
Publication number | Publication date |
---|---|
CN115997014A (en) | 2023-04-21 |
CA3167206A1 (en) | 2021-10-07 |
EP4103713A1 (en) | 2022-12-21 |
JP2023514576A (en) | 2023-04-06 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE INTERNATIONAL PUBLICATION HAS BEEN MADE |
|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: REQUEST FOR EXAMINATION WAS MADE |
|
17P | Request for examination filed |
Effective date: 20220810 |
|
AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR |
|
RAV | Requested validation state of the european patent: fee paid |
Extension state: MD Effective date: 20220908 Extension state: MA Effective date: 20220908 |
|
A4 | Supplementary search report drawn up and despatched |
Effective date: 20240216 |
|
RIC1 | Information provided on ipc code assigned before grant |
Ipc: A61P 31/16 20060101ALI20240212BHEP Ipc: C12N 15/11 20060101AFI20240212BHEP |