JP4895811B2 - サイトカイン阻害剤 - Google Patents
サイトカイン阻害剤 Download PDFInfo
- Publication number
- JP4895811B2 JP4895811B2 JP2006526272A JP2006526272A JP4895811B2 JP 4895811 B2 JP4895811 B2 JP 4895811B2 JP 2006526272 A JP2006526272 A JP 2006526272A JP 2006526272 A JP2006526272 A JP 2006526272A JP 4895811 B2 JP4895811 B2 JP 4895811B2
- Authority
- JP
- Japan
- Prior art keywords
- oxo
- tert
- butyl
- morpholin
- naphthalen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 102000004127 Cytokines Human genes 0.000 title description 68
- 108090000695 Cytokines Proteins 0.000 title description 67
- 239000003112 inhibitor Substances 0.000 title description 20
- -1 imidazolonyl Chemical group 0.000 claims description 809
- 125000000217 alkyl group Chemical group 0.000 claims description 613
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 188
- 125000004076 pyridyl group Chemical group 0.000 claims description 174
- 229910052717 sulfur Inorganic materials 0.000 claims description 153
- 229910052760 oxygen Inorganic materials 0.000 claims description 151
- 125000003545 alkoxy group Chemical group 0.000 claims description 150
- 125000000623 heterocyclic group Chemical group 0.000 claims description 146
- 125000002883 imidazolyl group Chemical group 0.000 claims description 134
- 125000001624 naphthyl group Chemical group 0.000 claims description 130
- 150000001875 compounds Chemical class 0.000 claims description 129
- 125000003226 pyrazolyl group Chemical group 0.000 claims description 109
- 125000003118 aryl group Chemical group 0.000 claims description 106
- 125000000714 pyrimidinyl group Chemical group 0.000 claims description 103
- 125000000168 pyrrolyl group Chemical group 0.000 claims description 101
- 125000004093 cyano group Chemical group *C#N 0.000 claims description 91
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 90
- 125000002098 pyridazinyl group Chemical group 0.000 claims description 90
- 229910052739 hydrogen Inorganic materials 0.000 claims description 89
- 239000001257 hydrogen Substances 0.000 claims description 89
- 125000001544 thienyl group Chemical group 0.000 claims description 83
- 125000002541 furyl group Chemical group 0.000 claims description 82
- 125000000842 isoxazolyl group Chemical group 0.000 claims description 76
- 125000005842 heteroatom Chemical group 0.000 claims description 73
- 125000000719 pyrrolidinyl group Chemical group 0.000 claims description 69
- 125000003373 pyrazinyl group Chemical group 0.000 claims description 67
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims description 65
- 125000003831 tetrazolyl group Chemical group 0.000 claims description 57
- 125000001786 isothiazolyl group Chemical group 0.000 claims description 53
- 125000004193 piperazinyl group Chemical group 0.000 claims description 51
- 125000000335 thiazolyl group Chemical group 0.000 claims description 51
- 125000000304 alkynyl group Chemical group 0.000 claims description 48
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 48
- 125000002971 oxazolyl group Chemical group 0.000 claims description 48
- 229910052801 chlorine Inorganic materials 0.000 claims description 44
- 229910052731 fluorine Inorganic materials 0.000 claims description 44
- 125000004415 heterocyclylalkyl group Chemical group 0.000 claims description 43
- 229910052794 bromium Inorganic materials 0.000 claims description 42
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 claims description 37
- 125000001712 tetrahydronaphthyl group Chemical group C1(CCCC2=CC=CC=C12)* 0.000 claims description 35
- 125000003710 aryl alkyl group Chemical group 0.000 claims description 34
- 150000002431 hydrogen Chemical class 0.000 claims description 34
- 125000000081 (C5-C8) cycloalkenyl group Chemical group 0.000 claims description 33
- 125000006576 di-(C1-C3-alkyl)-aminocarbonyl group Chemical group 0.000 claims description 33
- 125000005843 halogen group Chemical group 0.000 claims description 33
- 229910052757 nitrogen Inorganic materials 0.000 claims description 33
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 31
- 125000006376 (C3-C10) cycloalkyl group Chemical group 0.000 claims description 27
- 229910052740 iodine Inorganic materials 0.000 claims description 27
- 125000006374 C2-C10 alkenyl group Chemical group 0.000 claims description 17
- 125000004464 hydroxyphenyl group Chemical group 0.000 claims description 17
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims description 16
- 125000005037 alkyl phenyl group Chemical group 0.000 claims description 16
- 125000001072 heteroaryl group Chemical group 0.000 claims description 15
- 239000002253 acid Substances 0.000 claims description 14
- 125000001313 C5-C10 heteroaryl group Chemical group 0.000 claims description 11
- 125000001309 chloro group Chemical group Cl* 0.000 claims description 9
- 150000003839 salts Chemical class 0.000 claims description 9
- 239000012453 solvate Substances 0.000 claims description 9
- 125000001246 bromo group Chemical group Br* 0.000 claims description 4
- 150000004702 methyl esters Chemical class 0.000 claims description 3
- GHVRAPBHFZUHHM-UHFFFAOYSA-N n-(5-tert-butyl-2-methoxyphenyl)-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound COC1=CC=C(C(C)(C)C)C=C1NC(=O)C(=O)C(C1=CC=CC=C11)=CC=C1OCCN1CCOCC1 GHVRAPBHFZUHHM-UHFFFAOYSA-N 0.000 claims description 3
- RJEPRODGSSWEIO-UHFFFAOYSA-N 2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxo-n-(2-phenylcyclopropyl)acetamide Chemical compound C=1C=C(OCCN2CCOCC2)C2=CC=CC=C2C=1C(=O)C(=O)NC1CC1C1=CC=CC=C1 RJEPRODGSSWEIO-UHFFFAOYSA-N 0.000 claims description 2
- RJEPRODGSSWEIO-RPWUZVMVSA-N 2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxo-n-[(1s,2r)-2-phenylcyclopropyl]acetamide Chemical compound C1([C@H]2C[C@@H]2NC(=O)C(=O)C=2C3=CC=CC=C3C(OCCN3CCOCC3)=CC=2)=CC=CC=C1 RJEPRODGSSWEIO-RPWUZVMVSA-N 0.000 claims description 2
- AEDKRWDICCQKIH-UHFFFAOYSA-N 2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxo-n-[3-(trifluoromethyl)phenyl]acetamide Chemical compound FC(F)(F)C1=CC=CC(NC(=O)C(=O)C=2C3=CC=CC=C3C(OCCN3CCOCC3)=CC=2)=C1 AEDKRWDICCQKIH-UHFFFAOYSA-N 0.000 claims description 2
- SAWFAYWCDKYSMF-UHFFFAOYSA-N 2-[4-[2-(4-acetylpiperazin-1-yl)ethoxy]naphthalen-1-yl]-n-[5-tert-butyl-2-(4-methylphenyl)pyrazol-3-yl]-2-oxoacetamide Chemical compound C1CN(C(=O)C)CCN1CCOC(C1=CC=CC=C11)=CC=C1C(=O)C(=O)NC1=CC(C(C)(C)C)=NN1C1=CC=C(C)C=C1 SAWFAYWCDKYSMF-UHFFFAOYSA-N 0.000 claims description 2
- OTHGSPDUEPBQAC-UHFFFAOYSA-N 2-[4-[2-(4-acetylpiperazin-1-yl)ethoxy]naphthalen-1-yl]-n-[5-tert-butyl-3-(methanesulfonamido)-2-methoxyphenyl]-2-oxoacetamide Chemical compound C1=C(C(C)(C)C)C=C(NS(C)(=O)=O)C(OC)=C1NC(=O)C(=O)C(C1=CC=CC=C11)=CC=C1OCCN1CCN(C(C)=O)CC1 OTHGSPDUEPBQAC-UHFFFAOYSA-N 0.000 claims description 2
- SQGFXTIHAWNAEZ-UHFFFAOYSA-N 2-[4-[2-(4-acetylpiperazin-1-yl)ethyl]naphthalen-1-yl]-n-[5-tert-butyl-2-(4-methylphenyl)pyrazol-3-yl]-2-oxoacetamide Chemical compound C1CN(C(=O)C)CCN1CCC(C1=CC=CC=C11)=CC=C1C(=O)C(=O)NC1=CC(C(C)(C)C)=NN1C1=CC=C(C)C=C1 SQGFXTIHAWNAEZ-UHFFFAOYSA-N 0.000 claims description 2
- 125000003006 2-dimethylaminoethyl group Chemical group [H]C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])* 0.000 claims description 2
- 125000004200 2-methoxyethyl group Chemical group [H]C([H])([H])OC([H])([H])C([H])([H])* 0.000 claims description 2
- UEUMWGIUABGHOM-UHFFFAOYSA-N 3-tert-butyl-5-[[2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetyl]amino]-n-phenylpyrazole-1-carboxamide Chemical compound C=1C=CC=CC=1NC(=O)N1N=C(C(C)(C)C)C=C1NC(=O)C(=O)C(C1=CC=CC=C11)=CC=C1OCCN1CCOCC1 UEUMWGIUABGHOM-UHFFFAOYSA-N 0.000 claims description 2
- ONLRXOKCFLRNGX-UHFFFAOYSA-N 3-tert-butyl-5-[[2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetyl]amino]-n-propan-2-ylpyrazole-1-carboxamide Chemical compound CC(C)NC(=O)N1N=C(C(C)(C)C)C=C1NC(=O)C(=O)C(C1=CC=CC=C11)=CC=C1OCCN1CCOCC1 ONLRXOKCFLRNGX-UHFFFAOYSA-N 0.000 claims description 2
- OZAFLFDMHUWUOS-UHFFFAOYSA-N 3-tert-butyl-5-[[2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetyl]amino]-n-propylpyrazole-1-carboxamide Chemical compound CCCNC(=O)N1N=C(C(C)(C)C)C=C1NC(=O)C(=O)C(C1=CC=CC=C11)=CC=C1OCCN1CCOCC1 OZAFLFDMHUWUOS-UHFFFAOYSA-N 0.000 claims description 2
- BLATWTPTWPGVIM-UHFFFAOYSA-N 3-tert-butyl-5-[[2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetyl]amino]pyrazole-1-carboxamide Chemical compound NC(=O)N1N=C(C(C)(C)C)C=C1NC(=O)C(=O)C(C1=CC=CC=C11)=CC=C1OCCN1CCOCC1 BLATWTPTWPGVIM-UHFFFAOYSA-N 0.000 claims description 2
- XMZAQKDAWRWRTF-UHFFFAOYSA-N 3-tert-butyl-n-cyclohexyl-5-[[2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetyl]amino]pyrazole-1-carboxamide Chemical compound C1CCCCC1NC(=O)N1N=C(C(C)(C)C)C=C1NC(=O)C(=O)C(C1=CC=CC=C11)=CC=C1OCCN1CCOCC1 XMZAQKDAWRWRTF-UHFFFAOYSA-N 0.000 claims description 2
- YWBYYTWBEXASOQ-UHFFFAOYSA-N 5-tert-butyl-2-hydroxy-3-[[2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetyl]amino]benzamide Chemical compound NC(=O)C1=CC(C(C)(C)C)=CC(NC(=O)C(=O)C=2C3=CC=CC=C3C(OCCN3CCOCC3)=CC=2)=C1O YWBYYTWBEXASOQ-UHFFFAOYSA-N 0.000 claims description 2
- PMPFELVJEDKLCP-UHFFFAOYSA-N 5-tert-butyl-2-hydroxy-3-[[2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetyl]amino]benzoic acid Chemical compound OC(=O)C1=CC(C(C)(C)C)=CC(NC(=O)C(=O)C=2C3=CC=CC=C3C(OCCN3CCOCC3)=CC=2)=C1O PMPFELVJEDKLCP-UHFFFAOYSA-N 0.000 claims description 2
- NXNPXBJSTOYMNB-UHFFFAOYSA-N 5-tert-butyl-2-methoxy-3-[[2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetyl]amino]-n-propan-2-ylbenzamide Chemical compound C1=C(C(C)(C)C)C=C(C(=O)NC(C)C)C(OC)=C1NC(=O)C(=O)C(C1=CC=CC=C11)=CC=C1OCCN1CCOCC1 NXNPXBJSTOYMNB-UHFFFAOYSA-N 0.000 claims description 2
- CJJOIIYCGGNMSM-UHFFFAOYSA-N 5-tert-butyl-2-methoxy-3-[[2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetyl]amino]-n-propylbenzamide Chemical compound CCCNC(=O)C1=CC(C(C)(C)C)=CC(NC(=O)C(=O)C=2C3=CC=CC=C3C(OCCN3CCOCC3)=CC=2)=C1OC CJJOIIYCGGNMSM-UHFFFAOYSA-N 0.000 claims description 2
- JEDCYYXEEUPWRJ-UHFFFAOYSA-N 5-tert-butyl-2-methoxy-3-[[2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetyl]amino]-n-pyridin-2-ylbenzamide Chemical compound C1=C(C(C)(C)C)C=C(C(=O)NC=2N=CC=CC=2)C(OC)=C1NC(=O)C(=O)C(C1=CC=CC=C11)=CC=C1OCCN1CCOCC1 JEDCYYXEEUPWRJ-UHFFFAOYSA-N 0.000 claims description 2
- UHYBNCRNWRMIMN-UHFFFAOYSA-N 5-tert-butyl-2-methoxy-3-[[2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetyl]amino]benzamide Chemical compound C1=C(C(C)(C)C)C=C(C(N)=O)C(OC)=C1NC(=O)C(=O)C(C1=CC=CC=C11)=CC=C1OCCN1CCOCC1 UHYBNCRNWRMIMN-UHFFFAOYSA-N 0.000 claims description 2
- ZGSOLKDFJAKPJF-UHFFFAOYSA-N 5-tert-butyl-2-methoxy-3-[[2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetyl]amino]benzoic acid Chemical compound C1=C(C(C)(C)C)C=C(C(O)=O)C(OC)=C1NC(=O)C(=O)C(C1=CC=CC=C11)=CC=C1OCCN1CCOCC1 ZGSOLKDFJAKPJF-UHFFFAOYSA-N 0.000 claims description 2
- WNJSCQBYRFZIPN-UHFFFAOYSA-N 5-tert-butyl-2-methoxy-3-[[2-[4-[(2-morpholin-4-ylpyrimidin-4-yl)amino]naphthalen-1-yl]-2-oxoacetyl]amino]benzamide Chemical compound C1=C(C(C)(C)C)C=C(C(N)=O)C(OC)=C1NC(=O)C(=O)C(C1=CC=CC=C11)=CC=C1NC1=CC=NC(N2CCOCC2)=N1 WNJSCQBYRFZIPN-UHFFFAOYSA-N 0.000 claims description 2
- ZZGOHUDBNBCKRL-UHFFFAOYSA-N 5-tert-butyl-2-methoxy-n-(2-methoxyethyl)-3-[[2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetyl]amino]benzamide Chemical compound COCCNC(=O)C1=CC(C(C)(C)C)=CC(NC(=O)C(=O)C=2C3=CC=CC=C3C(OCCN3CCOCC3)=CC=2)=C1OC ZZGOHUDBNBCKRL-UHFFFAOYSA-N 0.000 claims description 2
- IJTBRSKMNJXHHK-UHFFFAOYSA-N 5-tert-butyl-2-methoxy-n-(2-methylpropyl)-3-[[2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetyl]amino]benzamide Chemical compound C1=C(C(C)(C)C)C=C(C(=O)NCC(C)C)C(OC)=C1NC(=O)C(=O)C(C1=CC=CC=C11)=CC=C1OCCN1CCOCC1 IJTBRSKMNJXHHK-UHFFFAOYSA-N 0.000 claims description 2
- DZJBBKSIKNZEHO-UHFFFAOYSA-N 5-tert-butyl-3-[[2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetyl]amino]thiophene-2-carboxamide Chemical compound S1C(C(C)(C)C)=CC(NC(=O)C(=O)C=2C3=CC=CC=C3C(OCCN3CCOCC3)=CC=2)=C1C(N)=O DZJBBKSIKNZEHO-UHFFFAOYSA-N 0.000 claims description 2
- PIPZSIIVFYUORL-UHFFFAOYSA-N 5-tert-butyl-3-[[2-[4-[[2-(dimethylamino)pyrimidin-4-yl]amino]naphthalen-1-yl]-2-oxoacetyl]amino]thiophene-2-carboxamide Chemical compound CN(C)C1=NC=CC(NC=2C3=CC=CC=C3C(C(=O)C(=O)NC3=C(SC(=C3)C(C)(C)C)C(N)=O)=CC=2)=N1 PIPZSIIVFYUORL-UHFFFAOYSA-N 0.000 claims description 2
- VKKIENWAVOLKAE-UHFFFAOYSA-N 5-tert-butyl-3-[[2-[7-chloro-4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetyl]amino]-2-methoxybenzamide Chemical compound C1=C(C(C)(C)C)C=C(C(N)=O)C(OC)=C1NC(=O)C(=O)C(C1=CC(Cl)=CC=C11)=CC=C1OCCN1CCOCC1 VKKIENWAVOLKAE-UHFFFAOYSA-N 0.000 claims description 2
- AXGMBPYXZNWKRP-UHFFFAOYSA-N 5-tert-butyl-3-[[2-[7-chloro-4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetyl]amino]-n-cyclopropyl-2-methoxybenzamide Chemical compound C1=C(C(C)(C)C)C=C(C(=O)NC2CC2)C(OC)=C1NC(=O)C(=O)C(C1=CC(Cl)=CC=C11)=CC=C1OCCN1CCOCC1 AXGMBPYXZNWKRP-UHFFFAOYSA-N 0.000 claims description 2
- PMFXSSRMKDNFKP-UHFFFAOYSA-N 5-tert-butyl-n,n-diethyl-2-methoxy-3-[[2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetyl]amino]benzamide Chemical compound CCN(CC)C(=O)C1=CC(C(C)(C)C)=CC(NC(=O)C(=O)C=2C3=CC=CC=C3C(OCCN3CCOCC3)=CC=2)=C1OC PMFXSSRMKDNFKP-UHFFFAOYSA-N 0.000 claims description 2
- ZBFZPZWKZJRNAA-UHFFFAOYSA-N 5-tert-butyl-n,n-dimethyl-3-[[2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetyl]amino]thiophene-2-carboxamide Chemical compound S1C(C(C)(C)C)=CC(NC(=O)C(=O)C=2C3=CC=CC=C3C(OCCN3CCOCC3)=CC=2)=C1C(=O)N(C)C ZBFZPZWKZJRNAA-UHFFFAOYSA-N 0.000 claims description 2
- AAMMRMTWXMWPTO-UHFFFAOYSA-N 5-tert-butyl-n-(cyclopropylmethyl)-2-methoxy-3-[[2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetyl]amino]benzamide Chemical compound C1=C(C(C)(C)C)C=C(C(=O)NCC2CC2)C(OC)=C1NC(=O)C(=O)C(C1=CC=CC=C11)=CC=C1OCCN1CCOCC1 AAMMRMTWXMWPTO-UHFFFAOYSA-N 0.000 claims description 2
- KZTYESNVSZDDTO-UHFFFAOYSA-N 5-tert-butyl-n-(furan-2-ylmethyl)-2-methoxy-3-[[2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetyl]amino]benzamide Chemical compound C1=C(C(C)(C)C)C=C(C(=O)NCC=2OC=CC=2)C(OC)=C1NC(=O)C(=O)C(C1=CC=CC=C11)=CC=C1OCCN1CCOCC1 KZTYESNVSZDDTO-UHFFFAOYSA-N 0.000 claims description 2
- MRJSAFKLYNNOFK-UHFFFAOYSA-N 5-tert-butyl-n-cyclopentyl-2-methoxy-3-[[2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetyl]amino]benzamide Chemical compound C1=C(C(C)(C)C)C=C(C(=O)NC2CCCC2)C(OC)=C1NC(=O)C(=O)C(C1=CC=CC=C11)=CC=C1OCCN1CCOCC1 MRJSAFKLYNNOFK-UHFFFAOYSA-N 0.000 claims description 2
- GCBLXOYMYLHGMF-UHFFFAOYSA-N 5-tert-butyl-n-cyclopropyl-2-methoxy-3-[[2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetyl]amino]benzamide Chemical compound C1=C(C(C)(C)C)C=C(C(=O)NC2CC2)C(OC)=C1NC(=O)C(=O)C(C1=CC=CC=C11)=CC=C1OCCN1CCOCC1 GCBLXOYMYLHGMF-UHFFFAOYSA-N 0.000 claims description 2
- GPLOWXPQCVMURR-UHFFFAOYSA-N 5-tert-butyl-n-cyclopropyl-2-methoxy-3-[[2-[4-(2-morpholin-4-ylpyrimidin-4-yl)oxynaphthalen-1-yl]-2-oxoacetyl]amino]benzamide Chemical compound C1=C(C(C)(C)C)C=C(C(=O)NC2CC2)C(OC)=C1NC(=O)C(=O)C(C1=CC=CC=C11)=CC=C1OC(N=1)=CC=NC=1N1CCOCC1 GPLOWXPQCVMURR-UHFFFAOYSA-N 0.000 claims description 2
- QFUHRYJOZBCJIM-UHFFFAOYSA-N 5-tert-butyl-n-ethyl-2-hydroxy-3-[[2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetyl]amino]benzamide Chemical compound CCNC(=O)C1=CC(C(C)(C)C)=CC(NC(=O)C(=O)C=2C3=CC=CC=C3C(OCCN3CCOCC3)=CC=2)=C1O QFUHRYJOZBCJIM-UHFFFAOYSA-N 0.000 claims description 2
- YDZSKMYIFDGHQQ-UHFFFAOYSA-N 5-tert-butyl-n-ethyl-2-methoxy-3-[[2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetyl]amino]benzamide Chemical compound CCNC(=O)C1=CC(C(C)(C)C)=CC(NC(=O)C(=O)C=2C3=CC=CC=C3C(OCCN3CCOCC3)=CC=2)=C1OC YDZSKMYIFDGHQQ-UHFFFAOYSA-N 0.000 claims description 2
- SKTSOYLBZOJGDY-UHFFFAOYSA-N 5-tert-butyl-n-methyl-3-[[2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetyl]amino]thiophene-2-carboxamide Chemical compound S1C(C(C)(C)C)=CC(NC(=O)C(=O)C=2C3=CC=CC=C3C(OCCN3CCOCC3)=CC=2)=C1C(=O)NC SKTSOYLBZOJGDY-UHFFFAOYSA-N 0.000 claims description 2
- MAOQWAAYLSAJAG-UHFFFAOYSA-N N-[5-tert-butyl-2-(4-methylphenyl)pyrazol-3-yl]-2-oxo-2-[4-[2-(3-oxo-2H-1,4-diazepin-1-yl)ethyl]naphthalen-1-yl]acetamide Chemical compound CC1=CC=C(C=C1)N2C(=CC(=N2)C(C)(C)C)NC(=O)C(=O)C3=CC=C(C4=CC=CC=C43)CCN5CC(=O)N=CC=C5 MAOQWAAYLSAJAG-UHFFFAOYSA-N 0.000 claims description 2
- VVIMUDKYLDLAJU-UHFFFAOYSA-N ethyl 2-[5-tert-butyl-2-methoxy-n-methylsulfonyl-3-[[2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetyl]amino]anilino]acetate Chemical compound CCOC(=O)CN(S(C)(=O)=O)C1=CC(C(C)(C)C)=CC(NC(=O)C(=O)C=2C3=CC=CC=C3C(OCCN3CCOCC3)=CC=2)=C1OC VVIMUDKYLDLAJU-UHFFFAOYSA-N 0.000 claims description 2
- CXDIDHCGZWQWKA-UHFFFAOYSA-N methyl 5-tert-butyl-3-[[2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetyl]amino]thiophene-2-carboxylate Chemical compound S1C(C(C)(C)C)=CC(NC(=O)C(=O)C=2C3=CC=CC=C3C(OCCN3CCOCC3)=CC=2)=C1C(=O)OC CXDIDHCGZWQWKA-UHFFFAOYSA-N 0.000 claims description 2
- IJSQZZCKDHTPSD-UHFFFAOYSA-N n,3-ditert-butyl-5-[[2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetyl]amino]pyrazole-1-carboxamide Chemical compound CC(C)(C)NC(=O)N1N=C(C(C)(C)C)C=C1NC(=O)C(=O)C(C1=CC=CC=C11)=CC=C1OCCN1CCOCC1 IJSQZZCKDHTPSD-UHFFFAOYSA-N 0.000 claims description 2
- GOTPZIQCGDCWPL-UHFFFAOYSA-N n-(1-adamantyl)-3-tert-butyl-5-[[2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetyl]amino]pyrazole-1-carboxamide Chemical compound C1C(C2)CC(C3)CC2CC13NC(=O)N1N=C(C(C)(C)C)C=C1NC(=O)C(=O)C(C1=CC=CC=C11)=CC=C1OCCN1CCOCC1 GOTPZIQCGDCWPL-UHFFFAOYSA-N 0.000 claims description 2
- FOXINTKAGJUDEG-UHFFFAOYSA-N n-(2,5-dimethylphenyl)-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound CC1=CC=C(C)C(NC(=O)C(=O)C=2C3=CC=CC=C3C(OCCN3CCOCC3)=CC=2)=C1 FOXINTKAGJUDEG-UHFFFAOYSA-N 0.000 claims description 2
- GMWFGTCYWDXLPB-UHFFFAOYSA-N n-(2,5-ditert-butylphenyl)-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound CC(C)(C)C1=CC=C(C(C)(C)C)C(NC(=O)C(=O)C=2C3=CC=CC=C3C(OCCN3CCOCC3)=CC=2)=C1 GMWFGTCYWDXLPB-UHFFFAOYSA-N 0.000 claims description 2
- YOKZLHUWWAZSFB-UHFFFAOYSA-N n-(2,5-ditert-butylpyrazol-3-yl)-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound CC(C)(C)N1N=C(C(C)(C)C)C=C1NC(=O)C(=O)C(C1=CC=CC=C11)=CC=C1OCCN1CCOCC1 YOKZLHUWWAZSFB-UHFFFAOYSA-N 0.000 claims description 2
- ZBCUSLWZRHATJO-UHFFFAOYSA-N n-(2-acetyl-5-tert-butylpyrazol-3-yl)-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound CC(=O)N1N=C(C(C)(C)C)C=C1NC(=O)C(=O)C(C1=CC=CC=C11)=CC=C1OCCN1CCOCC1 ZBCUSLWZRHATJO-UHFFFAOYSA-N 0.000 claims description 2
- YZOXCRKQGXDHRT-UHFFFAOYSA-N n-(2-benzoyl-5-tert-butylpyrazol-3-yl)-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound C=1C=CC=CC=1C(=O)N1N=C(C(C)(C)C)C=C1NC(=O)C(=O)C(C1=CC=CC=C11)=CC=C1OCCN1CCOCC1 YZOXCRKQGXDHRT-UHFFFAOYSA-N 0.000 claims description 2
- NYGPUSMTNRKKLZ-UHFFFAOYSA-N n-(2-benzyl-5-tert-butylpyrazol-3-yl)-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound C=1C=CC=CC=1CN1N=C(C(C)(C)C)C=C1NC(=O)C(=O)C(C1=CC=CC=C11)=CC=C1OCCN1CCOCC1 NYGPUSMTNRKKLZ-UHFFFAOYSA-N 0.000 claims description 2
- CKLVKADHWAYJPU-UHFFFAOYSA-N n-(2-methyl-5-propan-2-ylphenyl)-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound CC(C)C1=CC=C(C)C(NC(=O)C(=O)C=2C3=CC=CC=C3C(OCCN3CCOCC3)=CC=2)=C1 CKLVKADHWAYJPU-UHFFFAOYSA-N 0.000 claims description 2
- SUKFMRZDXZFTPQ-UHFFFAOYSA-N n-(3,4-dimethylphenyl)-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound C1=C(C)C(C)=CC=C1NC(=O)C(=O)C(C1=CC=CC=C11)=CC=C1OCCN1CCOCC1 SUKFMRZDXZFTPQ-UHFFFAOYSA-N 0.000 claims description 2
- BDNSDNJMAVRZIH-UHFFFAOYSA-N n-(3,5-ditert-butyl-2-hydroxyphenyl)-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound CC(C)(C)C1=CC(C(C)(C)C)=CC(NC(=O)C(=O)C=2C3=CC=CC=C3C(OCCN3CCOCC3)=CC=2)=C1O BDNSDNJMAVRZIH-UHFFFAOYSA-N 0.000 claims description 2
- JDRFUOFUBPUXNG-UHFFFAOYSA-N n-(3,5-ditert-butyl-2-methoxyphenyl)-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound C1=C(C(C)(C)C)C=C(C(C)(C)C)C(OC)=C1NC(=O)C(=O)C(C1=CC=CC=C11)=CC=C1OCCN1CCOCC1 JDRFUOFUBPUXNG-UHFFFAOYSA-N 0.000 claims description 2
- JNZWQDZJEZVRCK-UHFFFAOYSA-N n-(3,5-ditert-butylphenyl)-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound CC(C)(C)C1=CC(C(C)(C)C)=CC(NC(=O)C(=O)C=2C3=CC=CC=C3C(OCCN3CCOCC3)=CC=2)=C1 JNZWQDZJEZVRCK-UHFFFAOYSA-N 0.000 claims description 2
- AZMVNQYKELLYRE-UHFFFAOYSA-N n-(3-amino-5-tert-butyl-2-methoxyphenyl)-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound COC1=C(N)C=C(C(C)(C)C)C=C1NC(=O)C(=O)C(C1=CC=CC=C11)=CC=C1OCCN1CCOCC1 AZMVNQYKELLYRE-UHFFFAOYSA-N 0.000 claims description 2
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- VNHDQFUAVMMOQO-UHFFFAOYSA-N n-(3-amino-5-tert-butyl-2-methoxyphenyl)-2-[4-[(2-morpholin-4-ylpyrimidin-4-yl)amino]naphthalen-1-yl]-2-oxoacetamide Chemical compound COC1=C(N)C=C(C(C)(C)C)C=C1NC(=O)C(=O)C(C1=CC=CC=C11)=CC=C1NC1=CC=NC(N2CCOCC2)=N1 VNHDQFUAVMMOQO-UHFFFAOYSA-N 0.000 claims description 2
- KEEOETLICJGWPP-UHFFFAOYSA-N n-(3-amino-5-tert-butyl-2-methoxyphenyl)-2-[4-[[2-(methylamino)pyrimidin-4-yl]amino]naphthalen-1-yl]-2-oxoacetamide Chemical compound CNC1=NC=CC(NC=2C3=CC=CC=C3C(C(=O)C(=O)NC=3C(=C(N)C=C(C=3)C(C)(C)C)OC)=CC=2)=N1 KEEOETLICJGWPP-UHFFFAOYSA-N 0.000 claims description 2
- DMJNCMHJMLEJSQ-UHFFFAOYSA-N n-(3-amino-5-tert-butyl-2-methoxyphenyl)-2-naphthalen-1-yl-2-oxoacetamide Chemical compound COC1=C(N)C=C(C(C)(C)C)C=C1NC(=O)C(=O)C1=CC=CC2=CC=CC=C12 DMJNCMHJMLEJSQ-UHFFFAOYSA-N 0.000 claims description 2
- WPADCIKZURWWQM-NRFANRHFSA-N n-(3-amino-5-tert-butyl-2-methoxyphenyl)-2-oxo-2-[4-[[2-[[(1s)-1-phenylethyl]amino]pyrimidin-4-yl]amino]naphthalen-1-yl]acetamide Chemical compound COC1=C(N)C=C(C(C)(C)C)C=C1NC(=O)C(=O)C(C1=CC=CC=C11)=CC=C1NC1=CC=NC(N[C@@H](C)C=2C=CC=CC=2)=N1 WPADCIKZURWWQM-NRFANRHFSA-N 0.000 claims description 2
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- QNKWNESTSOPQLJ-UHFFFAOYSA-N n-(3-tert-butyl-1,2-oxazol-5-yl)-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound O1N=C(C(C)(C)C)C=C1NC(=O)C(=O)C(C1=CC=CC=C11)=CC=C1OCCN1CCOCC1 QNKWNESTSOPQLJ-UHFFFAOYSA-N 0.000 claims description 2
- NPNGKGSEIGDQQB-UHFFFAOYSA-N n-(3-tert-butylphenyl)-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound CC(C)(C)C1=CC=CC(NC(=O)C(=O)C=2C3=CC=CC=C3C(OCCN3CCOCC3)=CC=2)=C1 NPNGKGSEIGDQQB-UHFFFAOYSA-N 0.000 claims description 2
- NDCOXQWOLXUZAP-UHFFFAOYSA-N n-(4-tert-butylphenyl)-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound C1=CC(C(C)(C)C)=CC=C1NC(=O)C(=O)C(C1=CC=CC=C11)=CC=C1OCCN1CCOCC1 NDCOXQWOLXUZAP-UHFFFAOYSA-N 0.000 claims description 2
- YICSUCNKTZMZRN-UHFFFAOYSA-N n-(5-tert-butyl-1,2-oxazol-3-yl)-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound O1C(C(C)(C)C)=CC(NC(=O)C(=O)C=2C3=CC=CC=C3C(OCCN3CCOCC3)=CC=2)=N1 YICSUCNKTZMZRN-UHFFFAOYSA-N 0.000 claims description 2
- IWEVMKIIKJWIQT-UHFFFAOYSA-N n-(5-tert-butyl-1,2-oxazol-3-yl)-2-[4-(2-morpholin-4-ylpyrimidin-4-yl)oxynaphthalen-1-yl]-2-oxoacetamide Chemical compound O1C(C(C)(C)C)=CC(NC(=O)C(=O)C=2C3=CC=CC=C3C(OC=3N=C(N=CC=3)N3CCOCC3)=CC=2)=N1 IWEVMKIIKJWIQT-UHFFFAOYSA-N 0.000 claims description 2
- NVGAQTKWVSNMEE-UHFFFAOYSA-N n-(5-tert-butyl-1,2-oxazol-3-yl)-2-[4-(3-hydroxypropoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound O1C(C(C)(C)C)=CC(NC(=O)C(=O)C=2C3=CC=CC=C3C(OCCCO)=CC=2)=N1 NVGAQTKWVSNMEE-UHFFFAOYSA-N 0.000 claims description 2
- VKCVBNNIZZZTNA-UHFFFAOYSA-N n-(5-tert-butyl-1,2-oxazol-3-yl)-2-[4-[(2-morpholin-4-ylpyridin-4-yl)amino]naphthalen-1-yl]-2-oxoacetamide Chemical compound O1C(C(C)(C)C)=CC(NC(=O)C(=O)C=2C3=CC=CC=C3C(NC=3C=C(N=CC=3)N3CCOCC3)=CC=2)=N1 VKCVBNNIZZZTNA-UHFFFAOYSA-N 0.000 claims description 2
- BIUSIFGDFPPEKM-UHFFFAOYSA-N n-(5-tert-butyl-1,2-oxazol-3-yl)-2-[4-[(2-morpholin-4-ylpyrimidin-4-yl)amino]naphthalen-1-yl]-2-oxoacetamide Chemical compound O1C(C(C)(C)C)=CC(NC(=O)C(=O)C=2C3=CC=CC=C3C(NC=3N=C(N=CC=3)N3CCOCC3)=CC=2)=N1 BIUSIFGDFPPEKM-UHFFFAOYSA-N 0.000 claims description 2
- KYYDMLLJHLPDES-UHFFFAOYSA-N n-(5-tert-butyl-1,2-oxazol-3-yl)-2-[4-[6-(morpholin-4-ylmethyl)pyridin-3-yl]naphthalen-1-yl]-2-oxoacetamide Chemical compound O1C(C(C)(C)C)=CC(NC(=O)C(=O)C=2C3=CC=CC=C3C(C=3C=NC(CN4CCOCC4)=CC=3)=CC=2)=N1 KYYDMLLJHLPDES-UHFFFAOYSA-N 0.000 claims description 2
- SFCGZIMIBDUXAY-UHFFFAOYSA-N n-(5-tert-butyl-1,2-oxazol-3-yl)-2-[4-[[2-(dimethylamino)pyrimidin-4-yl]amino]naphthalen-1-yl]-2-oxoacetamide Chemical compound CN(C)C1=NC=CC(NC=2C3=CC=CC=C3C(C(=O)C(=O)NC3=NOC(=C3)C(C)(C)C)=CC=2)=N1 SFCGZIMIBDUXAY-UHFFFAOYSA-N 0.000 claims description 2
- GWMGXSUTAKUCQO-UHFFFAOYSA-N n-(5-tert-butyl-1h-pyrazol-3-yl)-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound N1N=C(C(C)(C)C)C=C1NC(=O)C(=O)C(C1=CC=CC=C11)=CC=C1OCCN1CCOCC1 GWMGXSUTAKUCQO-UHFFFAOYSA-N 0.000 claims description 2
- YCXWMIKLLQMSAR-UHFFFAOYSA-N n-(5-tert-butyl-2-cyclohexylpyrazol-3-yl)-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound C1CCCCC1N1N=C(C(C)(C)C)C=C1NC(=O)C(=O)C(C1=CC=CC=C11)=CC=C1OCCN1CCOCC1 YCXWMIKLLQMSAR-UHFFFAOYSA-N 0.000 claims description 2
- MBQPRQGGWOXWQA-UHFFFAOYSA-N n-(5-tert-butyl-2-ethoxyphenyl)-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound CCOC1=CC=C(C(C)(C)C)C=C1NC(=O)C(=O)C(C1=CC=CC=C11)=CC=C1OCCN1CCOCC1 MBQPRQGGWOXWQA-UHFFFAOYSA-N 0.000 claims description 2
- AIMKXNYNVHAHGE-UHFFFAOYSA-N n-(5-tert-butyl-2-hydroxy-3-methylphenyl)-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound CC1=CC(C(C)(C)C)=CC(NC(=O)C(=O)C=2C3=CC=CC=C3C(OCCN3CCOCC3)=CC=2)=C1O AIMKXNYNVHAHGE-UHFFFAOYSA-N 0.000 claims description 2
- HRWXESULEXYMNG-UHFFFAOYSA-N n-(5-tert-butyl-2-methoxy-3-methylphenyl)-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound COC1=C(C)C=C(C(C)(C)C)C=C1NC(=O)C(=O)C(C1=CC=CC=C11)=CC=C1OCCN1CCOCC1 HRWXESULEXYMNG-UHFFFAOYSA-N 0.000 claims description 2
- FNHGFASCDFXJKF-UHFFFAOYSA-N n-(5-tert-butyl-2-methoxyphenyl)-2-[4-(2-morpholin-4-ylpyrimidin-4-yl)oxynaphthalen-1-yl]-2-oxoacetamide Chemical compound COC1=CC=C(C(C)(C)C)C=C1NC(=O)C(=O)C(C1=CC=CC=C11)=CC=C1OC1=CC=NC(N2CCOCC2)=N1 FNHGFASCDFXJKF-UHFFFAOYSA-N 0.000 claims description 2
- RBLJRIREZZLBNG-UHFFFAOYSA-N n-(5-tert-butyl-2-methoxyphenyl)-2-[4-[(2-morpholin-4-ylpyridin-4-yl)amino]naphthalen-1-yl]-2-oxoacetamide Chemical compound COC1=CC=C(C(C)(C)C)C=C1NC(=O)C(=O)C(C1=CC=CC=C11)=CC=C1NC1=CC=NC(N2CCOCC2)=C1 RBLJRIREZZLBNG-UHFFFAOYSA-N 0.000 claims description 2
- HPQWLHXNYHBCEA-UHFFFAOYSA-N n-(5-tert-butyl-2-methoxyphenyl)-2-[4-[(2-morpholin-4-ylpyrimidin-4-yl)amino]naphthalen-1-yl]-2-oxoacetamide Chemical compound COC1=CC=C(C(C)(C)C)C=C1NC(=O)C(=O)C(C1=CC=CC=C11)=CC=C1NC1=CC=NC(N2CCOCC2)=N1 HPQWLHXNYHBCEA-UHFFFAOYSA-N 0.000 claims description 2
- LLIBZCPHHJQNGM-UHFFFAOYSA-N n-(5-tert-butyl-2-methoxyphenyl)-2-[4-[6-(morpholin-4-ylmethyl)pyridin-3-yl]naphthalen-1-yl]-2-oxoacetamide Chemical compound COC1=CC=C(C(C)(C)C)C=C1NC(=O)C(=O)C(C1=CC=CC=C11)=CC=C1C(C=N1)=CC=C1CN1CCOCC1 LLIBZCPHHJQNGM-UHFFFAOYSA-N 0.000 claims description 2
- XIMXXKWKAWOWGF-UHFFFAOYSA-N n-(5-tert-butyl-2-methoxyphenyl)-2-[4-[[2-(dimethylamino)pyrimidin-4-yl]amino]naphthalen-1-yl]-2-oxoacetamide Chemical compound COC1=CC=C(C(C)(C)C)C=C1NC(=O)C(=O)C(C1=CC=CC=C11)=CC=C1NC1=CC=NC(N(C)C)=N1 XIMXXKWKAWOWGF-UHFFFAOYSA-N 0.000 claims description 2
- MYMSGNONGAITCI-UHFFFAOYSA-N n-(5-tert-butyl-2-methoxyphenyl)-2-oxo-2-(4-pyridin-3-ylnaphthalen-1-yl)acetamide Chemical compound COC1=CC=C(C(C)(C)C)C=C1NC(=O)C(=O)C(C1=CC=CC=C11)=CC=C1C1=CC=CN=C1 MYMSGNONGAITCI-UHFFFAOYSA-N 0.000 claims description 2
- BCCDBNZRUVAZPR-UHFFFAOYSA-N n-(5-tert-butyl-2-methoxyphenyl)-2-oxo-2-[4-(2-piperidin-1-ylpyrimidin-4-yl)oxynaphthalen-1-yl]acetamide Chemical compound COC1=CC=C(C(C)(C)C)C=C1NC(=O)C(=O)C(C1=CC=CC=C11)=CC=C1OC1=CC=NC(N2CCCCC2)=N1 BCCDBNZRUVAZPR-UHFFFAOYSA-N 0.000 claims description 2
- ZQQQDKRLZGKCNS-QFIPXVFZSA-N n-(5-tert-butyl-2-methoxyphenyl)-2-oxo-2-[4-[[2-[[(1s)-1-phenylethyl]amino]pyrimidin-4-yl]amino]naphthalen-1-yl]acetamide Chemical compound COC1=CC=C(C(C)(C)C)C=C1NC(=O)C(=O)C(C1=CC=CC=C11)=CC=C1NC1=CC=NC(N[C@@H](C)C=2C=CC=CC=2)=N1 ZQQQDKRLZGKCNS-QFIPXVFZSA-N 0.000 claims description 2
- ONQABYHFFGWLSD-UHFFFAOYSA-N n-(5-tert-butyl-2-methylpyrazol-3-yl)-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound CN1N=C(C(C)(C)C)C=C1NC(=O)C(=O)C(C1=CC=CC=C11)=CC=C1OCCN1CCOCC1 ONQABYHFFGWLSD-UHFFFAOYSA-N 0.000 claims description 2
- RYJYCJAEOMXCMT-UHFFFAOYSA-N n-(5-tert-butyl-2-methylpyrazol-3-yl)-2-[4-(2-morpholin-4-ylpyrimidin-4-yl)oxynaphthalen-1-yl]-2-oxoacetamide Chemical compound CN1N=C(C(C)(C)C)C=C1NC(=O)C(=O)C(C1=CC=CC=C11)=CC=C1OC1=CC=NC(N2CCOCC2)=N1 RYJYCJAEOMXCMT-UHFFFAOYSA-N 0.000 claims description 2
- KQCSYRHCAKWBAC-UHFFFAOYSA-N n-(5-tert-butyl-2-methylpyrazol-3-yl)-2-[4-[(2-morpholin-4-ylpyrimidin-4-yl)amino]naphthalen-1-yl]-2-oxoacetamide Chemical compound CN1N=C(C(C)(C)C)C=C1NC(=O)C(=O)C(C1=CC=CC=C11)=CC=C1NC1=CC=NC(N2CCOCC2)=N1 KQCSYRHCAKWBAC-UHFFFAOYSA-N 0.000 claims description 2
- DUAYQVWFLWXVEU-UHFFFAOYSA-N n-(5-tert-butyl-2-methylpyrazol-3-yl)-2-[4-[(4-morpholin-4-ylpyrimidin-2-yl)amino]naphthalen-1-yl]-2-oxoacetamide Chemical compound CN1N=C(C(C)(C)C)C=C1NC(=O)C(=O)C(C1=CC=CC=C11)=CC=C1NC1=NC=CC(N2CCOCC2)=N1 DUAYQVWFLWXVEU-UHFFFAOYSA-N 0.000 claims description 2
- ZTWYEISFWJJJTC-UHFFFAOYSA-N n-(5-tert-butyl-2-methylpyrazol-3-yl)-2-[4-[6-(morpholin-4-ylmethyl)pyridin-3-yl]naphthalen-1-yl]-2-oxoacetamide Chemical compound CN1N=C(C(C)(C)C)C=C1NC(=O)C(=O)C(C1=CC=CC=C11)=CC=C1C(C=N1)=CC=C1CN1CCOCC1 ZTWYEISFWJJJTC-UHFFFAOYSA-N 0.000 claims description 2
- VACQJQSMWKNDEF-UHFFFAOYSA-N n-(5-tert-butyl-2-naphthalen-1-ylpyrazol-3-yl)-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound C=1C=CC2=CC=CC=C2C=1N1N=C(C(C)(C)C)C=C1NC(=O)C(=O)C(C1=CC=CC=C11)=CC=C1OCCN1CCOCC1 VACQJQSMWKNDEF-UHFFFAOYSA-N 0.000 claims description 2
- APFPMAPUIYGXQN-UHFFFAOYSA-N n-(5-tert-butyl-2-phenylpyrazol-3-yl)-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound C=1C=CC=CC=1N1N=C(C(C)(C)C)C=C1NC(=O)C(=O)C(C1=CC=CC=C11)=CC=C1OCCN1CCOCC1 APFPMAPUIYGXQN-UHFFFAOYSA-N 0.000 claims description 2
- NIJLJZXZICPWHI-UHFFFAOYSA-N n-(5-tert-butyl-2-propan-2-yloxyphenyl)-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound CC(C)OC1=CC=C(C(C)(C)C)C=C1NC(=O)C(=O)C(C1=CC=CC=C11)=CC=C1OCCN1CCOCC1 NIJLJZXZICPWHI-UHFFFAOYSA-N 0.000 claims description 2
- JQUTUFUVQNZOGP-UHFFFAOYSA-N n-(5-tert-butyl-3-chloro-2-methoxyphenyl)-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound COC1=C(Cl)C=C(C(C)(C)C)C=C1NC(=O)C(=O)C(C1=CC=CC=C11)=CC=C1OCCN1CCOCC1 JQUTUFUVQNZOGP-UHFFFAOYSA-N 0.000 claims description 2
- ZMGAZIPLMZBPFG-UHFFFAOYSA-N n-(5-tert-butylthiophen-3-yl)-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound S1C(C(C)(C)C)=CC(NC(=O)C(=O)C=2C3=CC=CC=C3C(OCCN3CCOCC3)=CC=2)=C1 ZMGAZIPLMZBPFG-UHFFFAOYSA-N 0.000 claims description 2
- BHTQSXPVZKCWAS-UHFFFAOYSA-N n-[2-(3-aminophenyl)-5-tert-butylpyrazol-3-yl]-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound C=1C=CC(N)=CC=1N1N=C(C(C)(C)C)C=C1NC(=O)C(=O)C(C1=CC=CC=C11)=CC=C1OCCN1CCOCC1 BHTQSXPVZKCWAS-UHFFFAOYSA-N 0.000 claims description 2
- LXFJUECJZPBGLM-UHFFFAOYSA-N n-[2-(4-acetylphenyl)-5-tert-butylpyrazol-3-yl]-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound C1=CC(C(=O)C)=CC=C1N1C(NC(=O)C(=O)C=2C3=CC=CC=C3C(OCCN3CCOCC3)=CC=2)=CC(C(C)(C)C)=N1 LXFJUECJZPBGLM-UHFFFAOYSA-N 0.000 claims description 2
- CTWPDJHKHQCSSD-UHFFFAOYSA-N n-[2-(4-bromophenyl)-5-tert-butylpyrazol-3-yl]-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound C=1C=C(Br)C=CC=1N1N=C(C(C)(C)C)C=C1NC(=O)C(=O)C(C1=CC=CC=C11)=CC=C1OCCN1CCOCC1 CTWPDJHKHQCSSD-UHFFFAOYSA-N 0.000 claims description 2
- ZEXLFVYJIOIASK-UHFFFAOYSA-N n-[2-(4-methylphenyl)-5-propan-2-ylpyrazol-3-yl]-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound C=1C=C(C)C=CC=1N1N=C(C(C)C)C=C1NC(=O)C(=O)C(C1=CC=CC=C11)=CC=C1OCCN1CCOCC1 ZEXLFVYJIOIASK-UHFFFAOYSA-N 0.000 claims description 2
- NXGIMXZBMNXYNE-UHFFFAOYSA-N n-[2-(benzenesulfonyl)-5-tert-butylpyrazol-3-yl]-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound C=1C=CC=CC=1S(=O)(=O)N1N=C(C(C)(C)C)C=C1NC(=O)C(=O)C(C1=CC=CC=C11)=CC=C1OCCN1CCOCC1 NXGIMXZBMNXYNE-UHFFFAOYSA-N 0.000 claims description 2
- KZWSLFRPOVRNHH-UHFFFAOYSA-N n-[2-bromo-5-(trifluoromethyl)phenyl]-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound FC(F)(F)C1=CC=C(Br)C(NC(=O)C(=O)C=2C3=CC=CC=C3C(OCCN3CCOCC3)=CC=2)=C1 KZWSLFRPOVRNHH-UHFFFAOYSA-N 0.000 claims description 2
- HGADCMCJIWMZTQ-UHFFFAOYSA-N n-[2-chloro-5-(trifluoromethyl)phenyl]-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound FC(F)(F)C1=CC=C(Cl)C(NC(=O)C(=O)C=2C3=CC=CC=C3C(OCCN3CCOCC3)=CC=2)=C1 HGADCMCJIWMZTQ-UHFFFAOYSA-N 0.000 claims description 2
- IHNCYNCUEZUHRG-UHFFFAOYSA-N n-[2-hydroxy-3,5-bis(2-methylbutan-2-yl)phenyl]-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound CCC(C)(C)C1=CC(C(C)(C)CC)=CC(NC(=O)C(=O)C=2C3=CC=CC=C3C(OCCN3CCOCC3)=CC=2)=C1O IHNCYNCUEZUHRG-UHFFFAOYSA-N 0.000 claims description 2
- HXDXBVWDXXFXEY-UHFFFAOYSA-N n-[2-methoxy-3,5-bis(2-methylbutan-2-yl)phenyl]-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound CCC(C)(C)C1=CC(C(C)(C)CC)=CC(NC(=O)C(=O)C=2C3=CC=CC=C3C(OCCN3CCOCC3)=CC=2)=C1OC HXDXBVWDXXFXEY-UHFFFAOYSA-N 0.000 claims description 2
- MIDKJWWNZVBXDK-UHFFFAOYSA-N n-[2-methoxy-5-(2-phenylpropan-2-yl)phenyl]-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound COC1=CC=C(C(C)(C)C=2C=CC=CC=2)C=C1NC(=O)C(=O)C(C1=CC=CC=C11)=CC=C1OCCN1CCOCC1 MIDKJWWNZVBXDK-UHFFFAOYSA-N 0.000 claims description 2
- NJEWXMSBYWCRAV-UHFFFAOYSA-N n-[2-methoxy-5-(trifluoromethyl)phenyl]-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound COC1=CC=C(C(F)(F)F)C=C1NC(=O)C(=O)C(C1=CC=CC=C11)=CC=C1OCCN1CCOCC1 NJEWXMSBYWCRAV-UHFFFAOYSA-N 0.000 claims description 2
- IZWKJTXMNKXBJU-UHFFFAOYSA-N n-[3-(4-acetylpiperazine-1-carbonyl)-5-tert-butyl-2-methoxyphenyl]-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound C1=C(C(C)(C)C)C=C(C(=O)N2CCN(CC2)C(C)=O)C(OC)=C1NC(=O)C(=O)C(C1=CC=CC=C11)=CC=C1OCCN1CCOCC1 IZWKJTXMNKXBJU-UHFFFAOYSA-N 0.000 claims description 2
- DPJYLCHHHMUFNM-UHFFFAOYSA-N n-[3-(benzenesulfonamido)-5-tert-butyl-2-methoxyphenyl]-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound C1=C(C(C)(C)C)C=C(NS(=O)(=O)C=2C=CC=CC=2)C(OC)=C1NC(=O)C(=O)C(C1=CC=CC=C11)=CC=C1OCCN1CCOCC1 DPJYLCHHHMUFNM-UHFFFAOYSA-N 0.000 claims description 2
- TWFOYJQVKPNAHA-UHFFFAOYSA-N n-[3-(benzylsulfonylamino)-5-tert-butyl-2-methoxyphenyl]-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound C1=C(C(C)(C)C)C=C(NS(=O)(=O)CC=2C=CC=CC=2)C(OC)=C1NC(=O)C(=O)C(C1=CC=CC=C11)=CC=C1OCCN1CCOCC1 TWFOYJQVKPNAHA-UHFFFAOYSA-N 0.000 claims description 2
- LXSKFXJXYUJSRL-UHFFFAOYSA-N n-[3-(methanesulfonamido)-2-methoxy-5-methylphenyl]-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound C1=C(C)C=C(NS(C)(=O)=O)C(OC)=C1NC(=O)C(=O)C(C1=CC=CC=C11)=CC=C1OCCN1CCOCC1 LXSKFXJXYUJSRL-UHFFFAOYSA-N 0.000 claims description 2
- VKYYOAMSXWQPHF-UHFFFAOYSA-N n-[3-(methanesulfonamido)-5-(trifluoromethyl)phenyl]-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound FC(F)(F)C1=CC(NS(=O)(=O)C)=CC(NC(=O)C(=O)C=2C3=CC=CC=C3C(OCCN3CCOCC3)=CC=2)=C1 VKYYOAMSXWQPHF-UHFFFAOYSA-N 0.000 claims description 2
- AUJYDDPHQWCTCX-UHFFFAOYSA-N n-[3-[(2-amino-2-oxoethyl)-methylsulfonylamino]-5-tert-butyl-2-methoxyphenyl]-2-naphthalen-1-yl-2-oxoacetamide Chemical compound C1=C(C(C)(C)C)C=C(N(CC(N)=O)S(C)(=O)=O)C(OC)=C1NC(=O)C(=O)C1=CC=CC2=CC=CC=C12 AUJYDDPHQWCTCX-UHFFFAOYSA-N 0.000 claims description 2
- NWVBFFJKNGLBOI-UHFFFAOYSA-N n-[3-amino-5-(trifluoromethyl)phenyl]-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound FC(F)(F)C1=CC(N)=CC(NC(=O)C(=O)C=2C3=CC=CC=C3C(OCCN3CCOCC3)=CC=2)=C1 NWVBFFJKNGLBOI-UHFFFAOYSA-N 0.000 claims description 2
- KMXQHQZTCSEHMU-UHFFFAOYSA-N n-[4-bromo-3-(trifluoromethyl)phenyl]-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound C1=C(Br)C(C(F)(F)F)=CC(NC(=O)C(=O)C=2C3=CC=CC=C3C(OCCN3CCOCC3)=CC=2)=C1 KMXQHQZTCSEHMU-UHFFFAOYSA-N 0.000 claims description 2
- LFBNKYGQNYBSCH-UHFFFAOYSA-N n-[4-chloro-3-(trifluoromethyl)phenyl]-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound C1=C(Cl)C(C(F)(F)F)=CC(NC(=O)C(=O)C=2C3=CC=CC=C3C(OCCN3CCOCC3)=CC=2)=C1 LFBNKYGQNYBSCH-UHFFFAOYSA-N 0.000 claims description 2
- JBUZPAYYXQPNRC-UHFFFAOYSA-N n-[4-fluoro-3-(trifluoromethyl)phenyl]-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound C1=C(C(F)(F)F)C(F)=CC=C1NC(=O)C(=O)C(C1=CC=CC=C11)=CC=C1OCCN1CCOCC1 JBUZPAYYXQPNRC-UHFFFAOYSA-N 0.000 claims description 2
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- QXLLQROHJOPELG-UHFFFAOYSA-N n-[5-(2-methylpentan-2-yl)-2-(4-methylphenyl)pyrazol-3-yl]-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound C=1C=C(C)C=CC=1N1N=C(C(C)(C)CCC)C=C1NC(=O)C(=O)C(C1=CC=CC=C11)=CC=C1OCCN1CCOCC1 QXLLQROHJOPELG-UHFFFAOYSA-N 0.000 claims description 2
- GHBKVEBOASMNCE-UHFFFAOYSA-N n-[5-tert-butyl-2-(2,3-dichlorophenyl)pyrazol-3-yl]-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound C=1C=CC(Cl)=C(Cl)C=1N1N=C(C(C)(C)C)C=C1NC(=O)C(=O)C(C1=CC=CC=C11)=CC=C1OCCN1CCOCC1 GHBKVEBOASMNCE-UHFFFAOYSA-N 0.000 claims description 2
- OBYUUXIPVPQYMO-UHFFFAOYSA-N n-[5-tert-butyl-2-(2,3-dimethylphenyl)pyrazol-3-yl]-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound CC1=CC=CC(N2C(=CC(=N2)C(C)(C)C)NC(=O)C(=O)C=2C3=CC=CC=C3C(OCCN3CCOCC3)=CC=2)=C1C OBYUUXIPVPQYMO-UHFFFAOYSA-N 0.000 claims description 2
- XIKHADGAOSJYHC-UHFFFAOYSA-N n-[5-tert-butyl-2-(2,4-dichlorophenyl)pyrazol-3-yl]-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound C=1C=C(Cl)C=C(Cl)C=1N1N=C(C(C)(C)C)C=C1NC(=O)C(=O)C(C1=CC=CC=C11)=CC=C1OCCN1CCOCC1 XIKHADGAOSJYHC-UHFFFAOYSA-N 0.000 claims description 2
- MBVXHAXQHPGQMA-UHFFFAOYSA-N n-[5-tert-butyl-2-(2,4-difluorophenyl)pyrazol-3-yl]-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound C=1C=C(F)C=C(F)C=1N1N=C(C(C)(C)C)C=C1NC(=O)C(=O)C(C1=CC=CC=C11)=CC=C1OCCN1CCOCC1 MBVXHAXQHPGQMA-UHFFFAOYSA-N 0.000 claims description 2
- JECNCEWOLYWOPG-UHFFFAOYSA-N n-[5-tert-butyl-2-(2,5-dichlorophenyl)pyrazol-3-yl]-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound C=1C(Cl)=CC=C(Cl)C=1N1N=C(C(C)(C)C)C=C1NC(=O)C(=O)C(C1=CC=CC=C11)=CC=C1OCCN1CCOCC1 JECNCEWOLYWOPG-UHFFFAOYSA-N 0.000 claims description 2
- HFZRUOGIEIPCAC-UHFFFAOYSA-N n-[5-tert-butyl-2-(2,5-difluorophenyl)pyrazol-3-yl]-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound C=1C(F)=CC=C(F)C=1N1N=C(C(C)(C)C)C=C1NC(=O)C(=O)C(C1=CC=CC=C11)=CC=C1OCCN1CCOCC1 HFZRUOGIEIPCAC-UHFFFAOYSA-N 0.000 claims description 2
- WDJSELWMGSEBTI-UHFFFAOYSA-N n-[5-tert-butyl-2-(2,5-dimethylphenyl)pyrazol-3-yl]-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound CC1=CC=C(C)C(N2C(=CC(=N2)C(C)(C)C)NC(=O)C(=O)C=2C3=CC=CC=C3C(OCCN3CCOCC3)=CC=2)=C1 WDJSELWMGSEBTI-UHFFFAOYSA-N 0.000 claims description 2
- OOLGXTRXXACWEA-UHFFFAOYSA-N n-[5-tert-butyl-2-(2-chlorophenyl)pyrazol-3-yl]-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound C=1C=CC=C(Cl)C=1N1N=C(C(C)(C)C)C=C1NC(=O)C(=O)C(C1=CC=CC=C11)=CC=C1OCCN1CCOCC1 OOLGXTRXXACWEA-UHFFFAOYSA-N 0.000 claims description 2
- HKNRETMMTGULKN-UHFFFAOYSA-N n-[5-tert-butyl-2-(2-methylphenyl)pyrazol-3-yl]-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound CC1=CC=CC=C1N1C(NC(=O)C(=O)C=2C3=CC=CC=C3C(OCCN3CCOCC3)=CC=2)=CC(C(C)(C)C)=N1 HKNRETMMTGULKN-UHFFFAOYSA-N 0.000 claims description 2
- ACLZWLPFORXEEN-UHFFFAOYSA-N n-[5-tert-butyl-2-(2-methylpropoxy)phenyl]-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound CC(C)COC1=CC=C(C(C)(C)C)C=C1NC(=O)C(=O)C(C1=CC=CC=C11)=CC=C1OCCN1CCOCC1 ACLZWLPFORXEEN-UHFFFAOYSA-N 0.000 claims description 2
- YVXHDLGWWKWCRW-UHFFFAOYSA-N n-[5-tert-butyl-2-(2-phenylacetyl)pyrazol-3-yl]-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound C=1C=CC=CC=1CC(=O)N1N=C(C(C)(C)C)C=C1NC(=O)C(=O)C(C1=CC=CC=C11)=CC=C1OCCN1CCOCC1 YVXHDLGWWKWCRW-UHFFFAOYSA-N 0.000 claims description 2
- UVYUUWPDALWLDI-UHFFFAOYSA-N n-[5-tert-butyl-2-(3,4-dichlorophenyl)pyrazol-3-yl]-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound C=1C=C(Cl)C(Cl)=CC=1N1N=C(C(C)(C)C)C=C1NC(=O)C(=O)C(C1=CC=CC=C11)=CC=C1OCCN1CCOCC1 UVYUUWPDALWLDI-UHFFFAOYSA-N 0.000 claims description 2
- OHLWVBVKQCVLQB-UHFFFAOYSA-N n-[5-tert-butyl-2-(3,4-dimethylphenyl)pyrazol-3-yl]-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound C1=C(C)C(C)=CC=C1N1C(NC(=O)C(=O)C=2C3=CC=CC=C3C(OCCN3CCOCC3)=CC=2)=CC(C(C)(C)C)=N1 OHLWVBVKQCVLQB-UHFFFAOYSA-N 0.000 claims description 2
- CAUOYLPQRLMXQE-UHFFFAOYSA-N n-[5-tert-butyl-2-(3,5-dichlorophenyl)pyrazol-3-yl]-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound C=1C(Cl)=CC(Cl)=CC=1N1N=C(C(C)(C)C)C=C1NC(=O)C(=O)C(C1=CC=CC=C11)=CC=C1OCCN1CCOCC1 CAUOYLPQRLMXQE-UHFFFAOYSA-N 0.000 claims description 2
- BALVHKZKXQVVDP-UHFFFAOYSA-N n-[5-tert-butyl-2-(3,5-dimethylphenyl)pyrazol-3-yl]-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound CC1=CC(C)=CC(N2C(=CC(=N2)C(C)(C)C)NC(=O)C(=O)C=2C3=CC=CC=C3C(OCCN3CCOCC3)=CC=2)=C1 BALVHKZKXQVVDP-UHFFFAOYSA-N 0.000 claims description 2
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- CXIVVVQOPYUYMM-UHFFFAOYSA-N n-[5-tert-butyl-2-(3-chlorobenzoyl)pyrazol-3-yl]-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound C=1C=CC(Cl)=CC=1C(=O)N1N=C(C(C)(C)C)C=C1NC(=O)C(=O)C(C1=CC=CC=C11)=CC=C1OCCN1CCOCC1 CXIVVVQOPYUYMM-UHFFFAOYSA-N 0.000 claims description 2
- ICQDHRCTZUGWLT-UHFFFAOYSA-N n-[5-tert-butyl-2-(3-chlorophenyl)pyrazol-3-yl]-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound C=1C=CC(Cl)=CC=1N1N=C(C(C)(C)C)C=C1NC(=O)C(=O)C(C1=CC=CC=C11)=CC=C1OCCN1CCOCC1 ICQDHRCTZUGWLT-UHFFFAOYSA-N 0.000 claims description 2
- QIRFKOKMUUQCDG-UHFFFAOYSA-N n-[5-tert-butyl-2-(3-chlorophenyl)sulfonylpyrazol-3-yl]-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound C=1C=CC(Cl)=CC=1S(=O)(=O)N1N=C(C(C)(C)C)C=C1NC(=O)C(=O)C(C1=CC=CC=C11)=CC=C1OCCN1CCOCC1 QIRFKOKMUUQCDG-UHFFFAOYSA-N 0.000 claims description 2
- PWDHTGNLCDFXCC-UHFFFAOYSA-N n-[5-tert-butyl-2-(3-cyanophenyl)pyrazol-3-yl]-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound C=1C=CC(C#N)=CC=1N1N=C(C(C)(C)C)C=C1NC(=O)C(=O)C(C1=CC=CC=C11)=CC=C1OCCN1CCOCC1 PWDHTGNLCDFXCC-UHFFFAOYSA-N 0.000 claims description 2
- BRDAZKBHNVQTRS-UHFFFAOYSA-N n-[5-tert-butyl-2-(3-fluoro-4-methylphenyl)pyrazol-3-yl]-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound C1=C(F)C(C)=CC=C1N1C(NC(=O)C(=O)C=2C3=CC=CC=C3C(OCCN3CCOCC3)=CC=2)=CC(C(C)(C)C)=N1 BRDAZKBHNVQTRS-UHFFFAOYSA-N 0.000 claims description 2
- QBOMNQTZLFCRKK-UHFFFAOYSA-N n-[5-tert-butyl-2-(3-fluorophenyl)pyrazol-3-yl]-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound C=1C=CC(F)=CC=1N1N=C(C(C)(C)C)C=C1NC(=O)C(=O)C(C1=CC=CC=C11)=CC=C1OCCN1CCOCC1 QBOMNQTZLFCRKK-UHFFFAOYSA-N 0.000 claims description 2
- KXIBNDFIIHQGLF-UHFFFAOYSA-N n-[5-tert-butyl-2-(3-methoxyphenyl)pyrazol-3-yl]-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound COC1=CC=CC(N2C(=CC(=N2)C(C)(C)C)NC(=O)C(=O)C=2C3=CC=CC=C3C(OCCN3CCOCC3)=CC=2)=C1 KXIBNDFIIHQGLF-UHFFFAOYSA-N 0.000 claims description 2
- WLHZOCKYDCYEKR-UHFFFAOYSA-N n-[5-tert-butyl-2-(3-methoxyphenyl)pyrazol-3-yl]-2-[4-[(2-morpholin-4-ylpyridin-4-yl)amino]naphthalen-1-yl]-2-oxoacetamide Chemical compound COC1=CC=CC(N2C(=CC(=N2)C(C)(C)C)NC(=O)C(=O)C=2C3=CC=CC=C3C(NC=3C=C(N=CC=3)N3CCOCC3)=CC=2)=C1 WLHZOCKYDCYEKR-UHFFFAOYSA-N 0.000 claims description 2
- WLOQSZJAQOBRFE-UHFFFAOYSA-N n-[5-tert-butyl-2-(3-methoxyphenyl)pyrazol-3-yl]-2-[4-[(2-morpholin-4-ylpyrimidin-4-yl)amino]naphthalen-1-yl]-2-oxoacetamide Chemical compound COC1=CC=CC(N2C(=CC(=N2)C(C)(C)C)NC(=O)C(=O)C=2C3=CC=CC=C3C(NC=3N=C(N=CC=3)N3CCOCC3)=CC=2)=C1 WLOQSZJAQOBRFE-UHFFFAOYSA-N 0.000 claims description 2
- LHVPJEKMQKNYJU-UHFFFAOYSA-N n-[5-tert-butyl-2-(3-methoxyphenyl)pyrazol-3-yl]-2-[4-[[2-(dimethylamino)pyrimidin-4-yl]amino]naphthalen-1-yl]-2-oxoacetamide Chemical compound COC1=CC=CC(N2C(=CC(=N2)C(C)(C)C)NC(=O)C(=O)C=2C3=CC=CC=C3C(NC=3N=C(N=CC=3)N(C)C)=CC=2)=C1 LHVPJEKMQKNYJU-UHFFFAOYSA-N 0.000 claims description 2
- IPWSPNZYVWESPU-UHFFFAOYSA-N n-[5-tert-butyl-2-(3-methylbenzoyl)pyrazol-3-yl]-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound CC1=CC=CC(C(=O)N2C(=CC(=N2)C(C)(C)C)NC(=O)C(=O)C=2C3=CC=CC=C3C(OCCN3CCOCC3)=CC=2)=C1 IPWSPNZYVWESPU-UHFFFAOYSA-N 0.000 claims description 2
- NDJIGWBGLINRRI-UHFFFAOYSA-N n-[5-tert-butyl-2-(3-methylphenyl)pyrazol-3-yl]-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound CC1=CC=CC(N2C(=CC(=N2)C(C)(C)C)NC(=O)C(=O)C=2C3=CC=CC=C3C(OCCN3CCOCC3)=CC=2)=C1 NDJIGWBGLINRRI-UHFFFAOYSA-N 0.000 claims description 2
- KLDUJDFUGLGEQK-UHFFFAOYSA-N n-[5-tert-butyl-2-(3-methylphenyl)pyrazol-3-yl]-2-[4-[(2-morpholin-4-ylpyrimidin-4-yl)amino]naphthalen-1-yl]-2-oxoacetamide Chemical compound CC1=CC=CC(N2C(=CC(=N2)C(C)(C)C)NC(=O)C(=O)C=2C3=CC=CC=C3C(NC=3N=C(N=CC=3)N3CCOCC3)=CC=2)=C1 KLDUJDFUGLGEQK-UHFFFAOYSA-N 0.000 claims description 2
- FJHLYOLONUOETL-UHFFFAOYSA-N n-[5-tert-butyl-2-(3-methylsulfonylphenyl)pyrazol-3-yl]-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound C=1C=CC(S(C)(=O)=O)=CC=1N1N=C(C(C)(C)C)C=C1NC(=O)C(=O)C(C1=CC=CC=C11)=CC=C1OCCN1CCOCC1 FJHLYOLONUOETL-UHFFFAOYSA-N 0.000 claims description 2
- USHSANZZMUSRKA-UHFFFAOYSA-N n-[5-tert-butyl-2-(3-nitrophenyl)pyrazol-3-yl]-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound C=1C=CC([N+]([O-])=O)=CC=1N1N=C(C(C)(C)C)C=C1NC(=O)C(=O)C(C1=CC=CC=C11)=CC=C1OCCN1CCOCC1 USHSANZZMUSRKA-UHFFFAOYSA-N 0.000 claims description 2
- GWUYPCRHNKUROU-UHFFFAOYSA-N n-[5-tert-butyl-2-(4-chlorophenyl)pyrazol-3-yl]-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound C=1C=C(Cl)C=CC=1N1N=C(C(C)(C)C)C=C1NC(=O)C(=O)C(C1=CC=CC=C11)=CC=C1OCCN1CCOCC1 GWUYPCRHNKUROU-UHFFFAOYSA-N 0.000 claims description 2
- UXGXXMXYEYSJOE-UHFFFAOYSA-N n-[5-tert-butyl-2-(4-cyanophenyl)pyrazol-3-yl]-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound C=1C=C(C#N)C=CC=1N1N=C(C(C)(C)C)C=C1NC(=O)C(=O)C(C1=CC=CC=C11)=CC=C1OCCN1CCOCC1 UXGXXMXYEYSJOE-UHFFFAOYSA-N 0.000 claims description 2
- DMZSWEMXIXYFDJ-UHFFFAOYSA-N n-[5-tert-butyl-2-(4-fluorophenyl)pyrazol-3-yl]-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound C=1C=C(F)C=CC=1N1N=C(C(C)(C)C)C=C1NC(=O)C(=O)C(C1=CC=CC=C11)=CC=C1OCCN1CCOCC1 DMZSWEMXIXYFDJ-UHFFFAOYSA-N 0.000 claims description 2
- VZXNRXHWROWZCV-UHFFFAOYSA-N n-[5-tert-butyl-2-(4-methoxyphenyl)pyrazol-3-yl]-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound C1=CC(OC)=CC=C1N1C(NC(=O)C(=O)C=2C3=CC=CC=C3C(OCCN3CCOCC3)=CC=2)=CC(C(C)(C)C)=N1 VZXNRXHWROWZCV-UHFFFAOYSA-N 0.000 claims description 2
- LNYBFILPLMPHNN-UHFFFAOYSA-N n-[5-tert-butyl-2-(4-methylbenzoyl)pyrazol-3-yl]-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound C1=CC(C)=CC=C1C(=O)N1C(NC(=O)C(=O)C=2C3=CC=CC=C3C(OCCN3CCOCC3)=CC=2)=CC(C(C)(C)C)=N1 LNYBFILPLMPHNN-UHFFFAOYSA-N 0.000 claims description 2
- JDBNVWJZMZATCK-UHFFFAOYSA-N n-[5-tert-butyl-2-(4-methylphenyl)pyrazol-3-yl]-2-[3-chloro-4-(2-morpholin-4-ylethoxy)phenyl]-2-oxoacetamide Chemical compound C1=CC(C)=CC=C1N1C(NC(=O)C(=O)C=2C=C(Cl)C(OCCN3CCOCC3)=CC=2)=CC(C(C)(C)C)=N1 JDBNVWJZMZATCK-UHFFFAOYSA-N 0.000 claims description 2
- MEVNIFZDIFKOCZ-UHFFFAOYSA-N n-[5-tert-butyl-2-(4-methylphenyl)pyrazol-3-yl]-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound C1=CC(C)=CC=C1N1C(NC(=O)C(=O)C=2C3=CC=CC=C3C(OCCN3CCOCC3)=CC=2)=CC(C(C)(C)C)=N1 MEVNIFZDIFKOCZ-UHFFFAOYSA-N 0.000 claims description 2
- GTAMXPWLQGWMGL-UHFFFAOYSA-N n-[5-tert-butyl-2-(4-methylphenyl)pyrazol-3-yl]-2-[4-(2-morpholin-4-ylpyrimidin-4-yl)oxynaphthalen-1-yl]-2-oxoacetamide Chemical compound C1=CC(C)=CC=C1N1C(NC(=O)C(=O)C=2C3=CC=CC=C3C(OC=3N=C(N=CC=3)N3CCOCC3)=CC=2)=CC(C(C)(C)C)=N1 GTAMXPWLQGWMGL-UHFFFAOYSA-N 0.000 claims description 2
- KGIRDMICAOKILV-UHFFFAOYSA-N n-[5-tert-butyl-2-(4-methylphenyl)pyrazol-3-yl]-2-[4-[(2-morpholin-4-ylpyridin-4-yl)amino]naphthalen-1-yl]-2-oxoacetamide Chemical compound C1=CC(C)=CC=C1N1C(NC(=O)C(=O)C=2C3=CC=CC=C3C(NC=3C=C(N=CC=3)N3CCOCC3)=CC=2)=CC(C(C)(C)C)=N1 KGIRDMICAOKILV-UHFFFAOYSA-N 0.000 claims description 2
- GTSQQRRXPFYYRT-UHFFFAOYSA-N n-[5-tert-butyl-2-(4-methylphenyl)pyrazol-3-yl]-2-[4-[(2-morpholin-4-ylpyrimidin-4-yl)amino]naphthalen-1-yl]-2-oxoacetamide Chemical compound C1=CC(C)=CC=C1N1C(NC(=O)C(=O)C=2C3=CC=CC=C3C(NC=3N=C(N=CC=3)N3CCOCC3)=CC=2)=CC(C(C)(C)C)=N1 GTSQQRRXPFYYRT-UHFFFAOYSA-N 0.000 claims description 2
- OXYPFEXCUCDTOE-UHFFFAOYSA-N n-[5-tert-butyl-2-(4-methylphenyl)pyrazol-3-yl]-2-[4-[2-(2,6-dimethylmorpholin-4-yl)ethoxy]naphthalen-1-yl]-2-oxoacetamide Chemical compound C1C(C)OC(C)CN1CCOC(C1=CC=CC=C11)=CC=C1C(=O)C(=O)NC1=CC(C(C)(C)C)=NN1C1=CC=C(C)C=C1 OXYPFEXCUCDTOE-UHFFFAOYSA-N 0.000 claims description 2
- BTCVSQNKIXZREL-UHFFFAOYSA-N n-[5-tert-butyl-2-(4-methylphenyl)pyrazol-3-yl]-2-[4-[2-(2,6-dimethylmorpholin-4-yl)ethyl]naphthalen-1-yl]-2-oxoacetamide Chemical compound C1C(C)OC(C)CN1CCC(C1=CC=CC=C11)=CC=C1C(=O)C(=O)NC1=CC(C(C)(C)C)=NN1C1=CC=C(C)C=C1 BTCVSQNKIXZREL-UHFFFAOYSA-N 0.000 claims description 2
- WBPZRDCPXMTWRJ-UHFFFAOYSA-N n-[5-tert-butyl-2-(4-methylphenyl)pyrazol-3-yl]-2-[4-[2-(4-methylpiperazin-1-yl)ethoxy]naphthalen-1-yl]-2-oxoacetamide Chemical compound C1CN(C)CCN1CCOC(C1=CC=CC=C11)=CC=C1C(=O)C(=O)NC1=CC(C(C)(C)C)=NN1C1=CC=C(C)C=C1 WBPZRDCPXMTWRJ-UHFFFAOYSA-N 0.000 claims description 2
- UPGUODJRUQPNGU-UHFFFAOYSA-N n-[5-tert-butyl-2-(4-methylphenyl)pyrazol-3-yl]-2-[4-[2-(4-methylpiperazin-1-yl)ethyl]naphthalen-1-yl]-2-oxoacetamide Chemical compound C1CN(C)CCN1CCC(C1=CC=CC=C11)=CC=C1C(=O)C(=O)NC1=CC(C(C)(C)C)=NN1C1=CC=C(C)C=C1 UPGUODJRUQPNGU-UHFFFAOYSA-N 0.000 claims description 2
- OXYPFEXCUCDTOE-DNQXCXABSA-N n-[5-tert-butyl-2-(4-methylphenyl)pyrazol-3-yl]-2-[4-[2-[(2r,6r)-2,6-dimethylmorpholin-4-yl]ethoxy]naphthalen-1-yl]-2-oxoacetamide Chemical compound C1[C@@H](C)O[C@H](C)CN1CCOC(C1=CC=CC=C11)=CC=C1C(=O)C(=O)NC1=CC(C(C)(C)C)=NN1C1=CC=C(C)C=C1 OXYPFEXCUCDTOE-DNQXCXABSA-N 0.000 claims description 2
- OXYPFEXCUCDTOE-PSWAGMNNSA-N n-[5-tert-butyl-2-(4-methylphenyl)pyrazol-3-yl]-2-[4-[2-[(2s,6r)-2,6-dimethylmorpholin-4-yl]ethoxy]naphthalen-1-yl]-2-oxoacetamide Chemical compound C1[C@@H](C)O[C@@H](C)CN1CCOC(C1=CC=CC=C11)=CC=C1C(=O)C(=O)NC1=CC(C(C)(C)C)=NN1C1=CC=C(C)C=C1 OXYPFEXCUCDTOE-PSWAGMNNSA-N 0.000 claims description 2
- SZPGGSJYCLQLBL-UHFFFAOYSA-N n-[5-tert-butyl-2-(4-methylphenyl)pyrazol-3-yl]-2-[4-[6-(morpholin-4-ylmethyl)pyridin-3-yl]naphthalen-1-yl]-2-oxoacetamide Chemical compound C1=CC(C)=CC=C1N1C(NC(=O)C(=O)C=2C3=CC=CC=C3C(C=3C=NC(CN4CCOCC4)=CC=3)=CC=2)=CC(C(C)(C)C)=N1 SZPGGSJYCLQLBL-UHFFFAOYSA-N 0.000 claims description 2
- KMJJCZVUYDIXTL-UHFFFAOYSA-N n-[5-tert-butyl-2-(4-methylphenyl)pyrazol-3-yl]-2-[7-chloro-4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound C1=CC(C)=CC=C1N1C(NC(=O)C(=O)C=2C3=CC(Cl)=CC=C3C(OCCN3CCOCC3)=CC=2)=CC(C(C)(C)C)=N1 KMJJCZVUYDIXTL-UHFFFAOYSA-N 0.000 claims description 2
- FZVFQDSBFGYBDB-UHFFFAOYSA-N n-[5-tert-butyl-2-(4-methylphenyl)pyrazol-3-yl]-2-oxo-2-[4-(2-pyridin-4-ylethoxy)naphthalen-1-yl]acetamide Chemical compound C1=CC(C)=CC=C1N1C(NC(=O)C(=O)C=2C3=CC=CC=C3C(OCCC=3C=CN=CC=3)=CC=2)=CC(C(C)(C)C)=N1 FZVFQDSBFGYBDB-UHFFFAOYSA-N 0.000 claims description 2
- SYPFVYGKNNXQLN-UHFFFAOYSA-N n-[5-tert-butyl-2-(4-methylphenyl)pyrazol-3-yl]-2-oxo-2-[4-(3-pyridin-4-ylpropoxy)naphthalen-1-yl]acetamide Chemical compound C1=CC(C)=CC=C1N1C(NC(=O)C(=O)C=2C3=CC=CC=C3C(OCCCC=3C=CN=CC=3)=CC=2)=CC(C(C)(C)C)=N1 SYPFVYGKNNXQLN-UHFFFAOYSA-N 0.000 claims description 2
- IMXGMEWHVAMODJ-UHFFFAOYSA-N n-[5-tert-butyl-2-(4-methylsulfonylphenyl)pyrazol-3-yl]-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound C=1C=C(S(C)(=O)=O)C=CC=1N1N=C(C(C)(C)C)C=C1NC(=O)C(=O)C(C1=CC=CC=C11)=CC=C1OCCN1CCOCC1 IMXGMEWHVAMODJ-UHFFFAOYSA-N 0.000 claims description 2
- CKAIKGOCBIYBCC-UHFFFAOYSA-N n-[5-tert-butyl-2-(4-sulfamoylphenyl)pyrazol-3-yl]-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound C=1C=C(S(N)(=O)=O)C=CC=1N1N=C(C(C)(C)C)C=C1NC(=O)C(=O)C(C1=CC=CC=C11)=CC=C1OCCN1CCOCC1 CKAIKGOCBIYBCC-UHFFFAOYSA-N 0.000 claims description 2
- VFJOVTHKLWNEAT-UHFFFAOYSA-N n-[5-tert-butyl-2-(6-chloropyridazin-3-yl)pyrazol-3-yl]-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound C=1C=C(Cl)N=NC=1N1N=C(C(C)(C)C)C=C1NC(=O)C(=O)C(C1=CC=CC=C11)=CC=C1OCCN1CCOCC1 VFJOVTHKLWNEAT-UHFFFAOYSA-N 0.000 claims description 2
- HXLFTRKRDXWTQY-UHFFFAOYSA-N n-[5-tert-butyl-2-(6-methylpyridin-3-yl)pyrazol-3-yl]-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound C1=NC(C)=CC=C1N1C(NC(=O)C(=O)C=2C3=CC=CC=C3C(OCCN3CCOCC3)=CC=2)=CC(C(C)(C)C)=N1 HXLFTRKRDXWTQY-UHFFFAOYSA-N 0.000 claims description 2
- OCJHBHZRYZIRKZ-UHFFFAOYSA-N n-[5-tert-butyl-2-(diethylamino)-3-(methanesulfonamido)phenyl]-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound C1=C(C(C)(C)C)C=C(NS(C)(=O)=O)C(N(CC)CC)=C1NC(=O)C(=O)C(C1=CC=CC=C11)=CC=C1OCCN1CCOCC1 OCJHBHZRYZIRKZ-UHFFFAOYSA-N 0.000 claims description 2
- PKZDBHMGJKXJRM-UHFFFAOYSA-N n-[5-tert-butyl-2-(morpholine-4-carbonyl)thiophen-3-yl]-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound C1COCCN1C(=O)C=1SC(C(C)(C)C)=CC=1NC(=O)C(=O)C(C1=CC=CC=C11)=CC=C1OCCN1CCOCC1 PKZDBHMGJKXJRM-UHFFFAOYSA-N 0.000 claims description 2
- HFLUCDPQUAEACH-UHFFFAOYSA-N n-[5-tert-butyl-2-[3-(carbamoylamino)phenyl]pyrazol-3-yl]-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound C=1C=CC(NC(N)=O)=CC=1N1N=C(C(C)(C)C)C=C1NC(=O)C(=O)C(C1=CC=CC=C11)=CC=C1OCCN1CCOCC1 HFLUCDPQUAEACH-UHFFFAOYSA-N 0.000 claims description 2
- NIYVAPRPWZJTIL-UHFFFAOYSA-N n-[5-tert-butyl-2-[3-(trifluoromethyl)benzoyl]pyrazol-3-yl]-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound C=1C=CC(C(F)(F)F)=CC=1C(=O)N1N=C(C(C)(C)C)C=C1NC(=O)C(=O)C(C1=CC=CC=C11)=CC=C1OCCN1CCOCC1 NIYVAPRPWZJTIL-UHFFFAOYSA-N 0.000 claims description 2
- XOKGFSVQBOOJEN-UHFFFAOYSA-N n-[5-tert-butyl-2-[4-(carbamoylamino)phenyl]pyrazol-3-yl]-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound C=1C=C(NC(N)=O)C=CC=1N1N=C(C(C)(C)C)C=C1NC(=O)C(=O)C(C1=CC=CC=C11)=CC=C1OCCN1CCOCC1 XOKGFSVQBOOJEN-UHFFFAOYSA-N 0.000 claims description 2
- WHDPRYKCFNISOU-UHFFFAOYSA-N n-[5-tert-butyl-2-[4-(trifluoromethyl)phenyl]pyrazol-3-yl]-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound C=1C=C(C(F)(F)F)C=CC=1N1N=C(C(C)(C)C)C=C1NC(=O)C(=O)C(C1=CC=CC=C11)=CC=C1OCCN1CCOCC1 WHDPRYKCFNISOU-UHFFFAOYSA-N 0.000 claims description 2
- SHDOEFWHXQMGRL-UHFFFAOYSA-N n-[5-tert-butyl-2-ethoxy-3-(methanesulfonamido)phenyl]-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound C1=C(C(C)(C)C)C=C(NS(C)(=O)=O)C(OCC)=C1NC(=O)C(=O)C(C1=CC=CC=C11)=CC=C1OCCN1CCOCC1 SHDOEFWHXQMGRL-UHFFFAOYSA-N 0.000 claims description 2
- ZSAWPPUKGUDLHI-UHFFFAOYSA-N n-[5-tert-butyl-2-hydroxy-3-(morpholin-4-ylmethyl)phenyl]-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound OC=1C(NC(=O)C(=O)C=2C3=CC=CC=C3C(OCCN3CCOCC3)=CC=2)=CC(C(C)(C)C)=CC=1CN1CCOCC1 ZSAWPPUKGUDLHI-UHFFFAOYSA-N 0.000 claims description 2
- PUDCQZDFNYFQNJ-UHFFFAOYSA-N n-[5-tert-butyl-2-hydroxy-3-(piperidin-1-ylmethyl)phenyl]-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound OC=1C(NC(=O)C(=O)C=2C3=CC=CC=C3C(OCCN3CCOCC3)=CC=2)=CC(C(C)(C)C)=CC=1CN1CCCCC1 PUDCQZDFNYFQNJ-UHFFFAOYSA-N 0.000 claims description 2
- KMJOCMLVKKSYNH-UHFFFAOYSA-N n-[5-tert-butyl-2-methoxy-3-(2,2,2-trifluoroethylsulfonylamino)phenyl]-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound C1=C(C(C)(C)C)C=C(NS(=O)(=O)CC(F)(F)F)C(OC)=C1NC(=O)C(=O)C(C1=CC=CC=C11)=CC=C1OCCN1CCOCC1 KMJOCMLVKKSYNH-UHFFFAOYSA-N 0.000 claims description 2
- CTDPKECAWWNOJF-UHFFFAOYSA-N n-[5-tert-butyl-2-methoxy-3-(3-oxopiperazine-1-carbonyl)phenyl]-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound C1=C(C(C)(C)C)C=C(C(=O)N2CC(=O)NCC2)C(OC)=C1NC(=O)C(=O)C(C1=CC=CC=C11)=CC=C1OCCN1CCOCC1 CTDPKECAWWNOJF-UHFFFAOYSA-N 0.000 claims description 2
- DPDSBDPSDYYSLY-UHFFFAOYSA-N n-[5-tert-butyl-2-methoxy-3-(morpholine-4-carbonyl)phenyl]-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound C1=C(C(C)(C)C)C=C(C(=O)N2CCOCC2)C(OC)=C1NC(=O)C(=O)C(C1=CC=CC=C11)=CC=C1OCCN1CCOCC1 DPDSBDPSDYYSLY-UHFFFAOYSA-N 0.000 claims description 2
- APPPYTFWOOONBT-UHFFFAOYSA-N n-[5-tert-butyl-2-methoxy-3-(piperidin-1-ylmethyl)phenyl]-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound C1=C(C(C)(C)C)C=C(NC(=O)C(=O)C=2C3=CC=CC=C3C(OCCN3CCOCC3)=CC=2)C(OC)=C1CN1CCCCC1 APPPYTFWOOONBT-UHFFFAOYSA-N 0.000 claims description 2
- DKGHIJQVPQVQIR-UHFFFAOYSA-N n-[5-tert-butyl-2-methoxy-3-(piperidine-1-carbonyl)phenyl]-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound C1=C(C(C)(C)C)C=C(C(=O)N2CCCCC2)C(OC)=C1NC(=O)C(=O)C(C1=CC=CC=C11)=CC=C1OCCN1CCOCC1 DKGHIJQVPQVQIR-UHFFFAOYSA-N 0.000 claims description 2
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| SG146624A1 (en) | 2008-10-30 |
| EP1670787A2 (en) | 2006-06-21 |
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| BRPI0414313A (pt) | 2006-11-07 |
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| US20100093734A1 (en) | 2010-04-15 |
| AU2004270733A1 (en) | 2005-03-17 |
| WO2005023761A2 (en) | 2005-03-17 |
| WO2005023761A3 (en) | 2005-07-14 |
| IL174010A0 (en) | 2006-08-01 |
| CA2538820A1 (en) | 2005-03-17 |
| US20100273797A1 (en) | 2010-10-28 |
| EP1670787A4 (en) | 2009-04-22 |
| US20050107399A1 (en) | 2005-05-19 |
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