AU2004270733B2 - Cytokine inhibitors - Google Patents
Cytokine inhibitors Download PDFInfo
- Publication number
- AU2004270733B2 AU2004270733B2 AU2004270733A AU2004270733A AU2004270733B2 AU 2004270733 B2 AU2004270733 B2 AU 2004270733B2 AU 2004270733 A AU2004270733 A AU 2004270733A AU 2004270733 A AU2004270733 A AU 2004270733A AU 2004270733 B2 AU2004270733 B2 AU 2004270733B2
- Authority
- AU
- Australia
- Prior art keywords
- oxo
- tert
- butyl
- naphthalen
- acetamide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
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- 108090000695 Cytokines Proteins 0.000 title claims description 75
- 239000003112 inhibitor Substances 0.000 title description 21
- -1 imidazolonyl Chemical group 0.000 claims description 817
- 125000000217 alkyl group Chemical group 0.000 claims description 741
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 186
- 125000004076 pyridyl group Chemical group 0.000 claims description 179
- 150000001875 compounds Chemical class 0.000 claims description 158
- 125000003545 alkoxy group Chemical group 0.000 claims description 150
- 125000000623 heterocyclic group Chemical group 0.000 claims description 146
- 125000002883 imidazolyl group Chemical group 0.000 claims description 134
- 125000001624 naphthyl group Chemical group 0.000 claims description 130
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 117
- 125000003226 pyrazolyl group Chemical group 0.000 claims description 109
- 125000003118 aryl group Chemical group 0.000 claims description 105
- 125000000714 pyrimidinyl group Chemical group 0.000 claims description 103
- 125000000168 pyrrolyl group Chemical group 0.000 claims description 101
- 125000004093 cyano group Chemical group *C#N 0.000 claims description 93
- 125000002098 pyridazinyl group Chemical group 0.000 claims description 90
- 229910052739 hydrogen Inorganic materials 0.000 claims description 89
- 239000001257 hydrogen Substances 0.000 claims description 88
- 125000001544 thienyl group Chemical group 0.000 claims description 83
- 125000002541 furyl group Chemical group 0.000 claims description 82
- 125000005842 heteroatom Chemical group 0.000 claims description 76
- 125000000842 isoxazolyl group Chemical group 0.000 claims description 76
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 73
- 125000003373 pyrazinyl group Chemical group 0.000 claims description 73
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims description 71
- 125000000719 pyrrolidinyl group Chemical group 0.000 claims description 69
- 125000000304 alkynyl group Chemical group 0.000 claims description 68
- 125000001637 1-naphthyl group Chemical group [H]C1=C([H])C([H])=C2C(*)=C([H])C([H])=C([H])C2=C1[H] 0.000 claims description 63
- 125000003831 tetrazolyl group Chemical group 0.000 claims description 57
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- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 54
- 125000001786 isothiazolyl group Chemical group 0.000 claims description 53
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- 125000000335 thiazolyl group Chemical group 0.000 claims description 51
- 229910052717 sulfur Inorganic materials 0.000 claims description 50
- 125000001301 ethoxy group Chemical group [H]C([H])([H])C([H])([H])O* 0.000 claims description 49
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 49
- 125000002971 oxazolyl group Chemical group 0.000 claims description 48
- 229910052801 chlorine Inorganic materials 0.000 claims description 46
- 229910052731 fluorine Inorganic materials 0.000 claims description 46
- 125000004415 heterocyclylalkyl group Chemical group 0.000 claims description 45
- 229910052794 bromium Inorganic materials 0.000 claims description 44
- 125000000392 cycloalkenyl group Chemical group 0.000 claims description 39
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 38
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- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims description 32
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- 2004-09-10 AU AU2004270733A patent/AU2004270733B2/en not_active Ceased
- 2004-09-10 SG SG200806677-1A patent/SG146624A1/en unknown
- 2004-09-10 EP EP04809707A patent/EP1670787B1/en not_active Expired - Lifetime
- 2004-09-10 JP JP2006526272A patent/JP4895811B2/ja not_active Expired - Fee Related
- 2004-09-10 MX MXPA06002853A patent/MXPA06002853A/es active IP Right Grant
- 2004-09-10 US US10/939,324 patent/US7749999B2/en not_active Expired - Fee Related
- 2004-09-10 WO PCT/US2004/029372 patent/WO2005023761A2/en not_active Ceased
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Also Published As
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|---|---|
| AU2004270733A1 (en) | 2005-03-17 |
| JP2007505127A (ja) | 2007-03-08 |
| US7897599B2 (en) | 2011-03-01 |
| US20100093734A1 (en) | 2010-04-15 |
| US20050107399A1 (en) | 2005-05-19 |
| MXPA06002853A (es) | 2006-06-14 |
| EP1670787B1 (en) | 2012-05-30 |
| WO2005023761A3 (en) | 2005-07-14 |
| WO2005023761A2 (en) | 2005-03-17 |
| CA2538820A1 (en) | 2005-03-17 |
| EP1670787A2 (en) | 2006-06-21 |
| US7919617B2 (en) | 2011-04-05 |
| SG146624A1 (en) | 2008-10-30 |
| US20100093735A1 (en) | 2010-04-15 |
| BRPI0414313A (pt) | 2006-11-07 |
| JP4895811B2 (ja) | 2012-03-14 |
| US20100273797A1 (en) | 2010-10-28 |
| IL174010A0 (en) | 2006-08-01 |
| CN102060806A (zh) | 2011-05-18 |
| US7749999B2 (en) | 2010-07-06 |
| HK1091210A1 (en) | 2007-01-12 |
| EP1670787A4 (en) | 2009-04-22 |
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